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1. Pulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study

Author

Sonnweber, Thomas, Grubwieser, Philipp, Pizzini, Alex, Boehm, Anna, Sahanic, Sabina, Luger, Anna, Schwabl, Christoph, Widmann, Gerlig, Egger, Alexander, Hoermann, Gregor, Wöll, Ewald, Puchner, Bernhard, Kaser, Susanne, Theurl, Igor, Nairz, Manfred, Tymoszuk, Piotr, Weiss, Günter, Joannidis, Michael, Löffler-Ragg, Judith, and Tancevski, Ivan

Published
2023
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2. Persistent somatic symptoms are key to individual illness perception at one year after COVID-19 in a cross-sectional analysis of a prospective cohort study

Author

Hüfner, Katharina, Tymoszuk, Piotr, Sahanic, Sabina, Luger, Anna, Boehm, Anna, Pizzini, Alex, Schwabl, Christoph, Koppelstätter, Sabine, Kurz, Katharina, Asshoff, Malte, Mosheimer-Feistritzer, Birgit, Pfeifer, Bernhard, Rass, Verena, Schroll, Andrea, Iglseder, Sarah, Egger, Alexander, Wöll, Ewald, Weiss, Günter, Helbok, Raimund, Widmann, Gerlig, Sonnweber, Thomas, Tancevski, Ivan, Sperner-Unterweger, Barbara, and Löffler-Ragg, Judith

Published
2023
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3. Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19

Author

Nairz, Manfred, Sahanic, Sabina, Pizzini, Alex, Böhm, Anna, Tymoszuk, Piotr, Mitterstiller, Anna-Maria, von Raffay, Laura, Grubwieser, Philipp, Bellmann-Weiler, Rosa, Koppelstätter, Sabine, Schroll, Andrea, Haschka, David, Zimmermann, Martina, Blunder, Silvia, Trattnig, Kristina, Naschberger, Helene, Klotz, Werner, Theurl, Igor, Petzer, Verena, Gehrer, Clemens, Mindur, John E., Luger, Anna, Schwabl, Christoph, Widmann, Gerlig, Weiss, Günter, Löffler-Ragg, Judith, Tancevski, Ivan, and Sonnweber, Thomas

Published
2022
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8. Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study

Author

Sonnweber, Thomas, Boehm, Anna, Sahanic, Sabina, Pizzini, Alex, Aichner, Magdalena, Sonnweber, Bettina, Kurz, Katharina, Koppelstätter, Sabine, Haschka, David, Petzer, Verena, Hilbe, Richard, Theurl, Markus, Lehner, Daniela, Nairz, Manfred, Puchner, Bernhard, Luger, Anna, Schwabl, Christoph, Bellmann-Weiler, Rosa, Wöll, Ewald, Widmann, Gerlig, Tancevski, Ivan, Judith-Löffler-Ragg, and Weiss, Günter

Published
2020
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10. COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicenter trial

Author

Sahanic, Sabina, primary, Tymoszuk, Piotr, additional, Luger, Anna K., additional, Hüfner, Katharina, additional, Boehm, Anna, additional, Pizzini, Alex, additional, Schwabl, Christoph, additional, Koppelstätter, Sabine, additional, Kurz, Katharina, additional, Asshoff, Malte, additional, Mosheimer-Feistritzer, Birgit, additional, Coen, Maximilian, additional, Pfeifer, Bernhard, additional, Rass, Verena, additional, Egger, Alexander, additional, Hörmann, Gregor, additional, Sperner-Unterweger, Barbara, additional, Helbok, Raimund, additional, Wöll, Ewald, additional, Weiss, Günter, additional, Widmann, Gerlig, additional, Tancevski, Ivan, additional, Sonnweber, Thomas, additional, and Löffler-Ragg, Judith, additional

Published
2023
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11. Impact of Dual-Energy Computed Tomography (DECT) Postprocessing Protocols on Detection of Monosodium Urate (MSU) Deposits in Foot Tendons of Cadavers

Author

Klauser, Andrea Sabine, Strobl, Sylvia, Schwabl, Christoph, Kremser, Christian, Klotz, Werner, Nikodinovska, Violeta Vasilevska, Stofferin, Hannes, Scharll, Yannick, Halpern, Ethan, Klauser, Andrea Sabine, Strobl, Sylvia, Schwabl, Christoph, Kremser, Christian, Klotz, Werner, Nikodinovska, Violeta Vasilevska, Stofferin, Hannes, Scharll, Yannick, and Halpern, Ethan

Abstract

Objective: To evaluate two different dual-energy computed tomography (DECT) post-processing protocols for the detection of MSU deposits in foot tendons of cadavers with verification by polarizing light microscopy as the gold standard. Material and Methods: A total of 40 embalmed cadavers (15 male; 25 female; median age, 82 years; mean, 80 years; range, 52–99; SD ± 10.9) underwent DECT to assess MSU deposits in foot tendons. Two postprocessing DECT protocols with different Hounsfield unit (HU) thresholds, 150/500 (=established) versus 120/500 (=modified). HU were applied to dual source acquisition with 80 kV for tube A and 140 kV for tube B. Six fresh cadavers (4 male; 2 female; median age, 78; mean, 78.5; range 61–95) were examined by DECT. Tendon dissection of 2/6 fresh cadavers with positive DECT 120 and negative DECT 150 studies were used to verify MSU deposits by polarizing light microscopy. Results: The tibialis anterior tendon was found positive in 57.5%/100% (DECT 150/120), the peroneus tendon in 35%/100%, the achilles tendon in 25%/90%, the flexor halluces longus tendon in 10%/100%, and the tibialis posterior tendon in 12.5%/97.5%. DECT 120 resulted in increased tendon MSU deposit detection, when DECT 150 was negative, with an overall agreement between DECT 150 and DECT 120 of 80% (p = 0.013). Polarizing light microscope confirmed MSU deposits detected only by DECT 120 in the tibialis anterior, the achilles, the flexor halluces longus, and the peroneal tendons. Conclusion: The DECT 120 protocol showed a higher sensitivity when compared to DECT 150.

Published
2023

13. Persistent somatic symptoms are key to individual illness perception at one year after COVID-19

Author

Hüfner, Katharina, primary, Tymoszuk, Piotr, additional, Sahanic, Sabina, additional, Luger, Anna, additional, Boehm, Anna, additional, Pizzini, Alex, additional, Schwabl, Christoph, additional, Koppelstätter, Sabine, additional, Kurz, Katharina, additional, Asshoff, Malte, additional, Mosheimer-Feistritzer, Birgit, additional, Pfeifer, Bernhard, additional, Rass, Verena, additional, Schroll, Andrea, additional, Iglseder, Sarah, additional, Egger, Alexander, additional, Wöll, Ewald, additional, Weiss, Günter, additional, Helbok, Raimund, additional, Widmann, Gerlig, additional, Sonnweber, Thomas, additional, Tancevski, Ivan, additional, Sperner-Unterweger, Barbara, additional, and Löffler-Ragg, Judith, additional

Published
2022
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14. Chest CT of Lung Injury 1 Year after COVID-19 Pneumonia: The CovILD Study

Author

Luger, Anna K., primary, Sonnweber, Thomas, additional, Gruber, Leonhard, additional, Schwabl, Christoph, additional, Cima, Katharina, additional, Tymoszuk, Piotr, additional, Gerstner, Anna K., additional, Pizzini, Alex, additional, Sahanic, Sabina, additional, Boehm, Anna, additional, Coen, Maximilian, additional, Strolz, Carola J., additional, Wöll, Ewald, additional, Weiss, Günter, additional, Kirchmair, Rudolf, additional, Feuchtner, Gudrun M., additional, Prosch, Helmut, additional, Tancevski, Ivan, additional, Löffler-Ragg, Judith, additional, and Widmann, Gerlig, additional

Published
2022
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18. The Impact of Iron Dyshomeostasis and Anaemia on Long-Term Pulmonary Recovery and Persisting Symptom Burden after COVID-19: A Prospective Observational Cohort Study

Author

Sonnweber, Thomas, primary, Grubwieser, Philipp, additional, Sahanic, Sabina, additional, Böhm, Anna Katharina, additional, Pizzini, Alex, additional, Luger, Anna, additional, Schwabl, Christoph, additional, Koppelstätter, Sabine, additional, Kurz, Katharina, additional, Puchner, Bernhard, additional, Sperner-Unterweger, Barbara, additional, Hüfner, Katharina, additional, Wöll, Ewald, additional, Nairz, Manfred, additional, Widmann, Gerlig, additional, Tancevski, Ivan, additional, Löffler-Ragg, Judith, additional, and Weiss, Günter, additional

Published
2022
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19. Prevalence of Monosodium Urate (MSU) Deposits in Cadavers Detected by Dual-Energy Computed Tomography (DECT)

Author

Klauser, Andrea S., primary, Strobl, Sylvia, additional, Schwabl, Christoph, additional, Klotz, Werner, additional, Feuchtner, Gudrun, additional, Moriggl, Bernhard, additional, Held, Julia, additional, Taljanovic, Mihra, additional, Weaver, Jennifer S., additional, Reijnierse, Monique, additional, Gizewski, Elke R., additional, and Stofferin, Hannes, additional

Published
2022
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20. Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial

Author

Sonnweber, Thomas, primary, Tymoszuk, Piotr, primary, Sahanic, Sabina, additional, Boehm, Anna, additional, Pizzini, Alex, additional, Luger, Anna, additional, Schwabl, Christoph, additional, Nairz, Manfred, additional, Grubwieser, Philipp, additional, Kurz, Katharina, additional, Koppelstätter, Sabine, additional, Aichner, Magdalena, additional, Puchner, Bernhard, additional, Egger, Alexander, additional, Hoermann, Gregor, additional, Wöll, Ewald, additional, Weiss, Günter, additional, Widmann, Gerlig, additional, Tancevski, Ivan, additional, and Löffler-Ragg, Judith, additional

Published
2022
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21. Author response: Investigating phenotypes of pulmonary COVID-19 recovery: A longitudinal observational prospective multicenter trial

Author

Sonnweber, Thomas, primary, Tymoszuk, Piotr, primary, Sahanic, Sabina, additional, Boehm, Anna, additional, Pizzini, Alex, additional, Luger, Anna, additional, Schwabl, Christoph, additional, Nairz, Manfred, additional, Grubwieser, Philipp, additional, Kurz, Katharina, additional, Koppelstätter, Sabine, additional, Aichner, Magdalena, additional, Puchner, Bernhard, additional, Egger, Alexander, additional, Hoermann, Gregor, additional, Wöll, Ewald, additional, Weiss, Günter, additional, Widmann, Gerlig, additional, Tancevski, Ivan, additional, and Löffler-Ragg, Judith, additional

Published
2022
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22. Investigating phenotypes of pulmonary COVID-19 recovery – a longitudinal observational prospective multicenter trial

Author

Sonnweber, Thomas, primary, Tymoszuk, Piotr, additional, Sahanic, Sabina, additional, Boehm, Anna, additional, Pizzini, Alex, additional, Luger, Anna, additional, Schwabl, Christoph, additional, Nairz, Manfred, additional, Kurz, Katharina, additional, Koppelstätter, Sabine, additional, Aichner, Magdalena, additional, Puchner, Bernhard, additional, Egger, Alexander, additional, Hoermann, Gregor, additional, Wöll, Ewald, additional, Weiss, Günter, additional, Widmann, Gerlig, additional, Tancevski, Ivan, additional, and Löffler-Ragg, Judith, additional

Published
2021
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25. Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

Author

Sonnweber, Thomas, primary, Sahanic, Sabina, additional, Pizzini, Alex, additional, Luger, Anna, additional, Schwabl, Christoph, additional, Sonnweber, Bettina, additional, Kurz, Katharina, additional, Koppelstätter, Sabine, additional, Haschka, David, additional, Petzer, Verena, additional, Boehm, Anna, additional, Aichner, Magdalena, additional, Tymoszuk, Piotr, additional, Lener, Daniela, additional, Theurl, Markus, additional, Lorsbach-Köhler, Almut, additional, Tancevski, Amra, additional, Schapfl, Anna, additional, Schaber, Marc, additional, Hilbe, Richard, additional, Nairz, Manfred, additional, Puchner, Bernhard, additional, Hüttenberger, Doris, additional, Tschurtschenthaler, Christoph, additional, Aßhoff, Malte, additional, Peer, Andreas, additional, Hartig, Frank, additional, Bellmann, Romuald, additional, Joannidis, Michael, additional, Gollmann-Tepeköylü, Can, additional, Holfeld, Johannes, additional, Feuchtner, Gudrun, additional, Egger, Alexander, additional, Hoermann, Gregor, additional, Schroll, Andrea, additional, Fritsche, Gernot, additional, Wildner, Sophie, additional, Bellmann-Weiler, Rosa, additional, Kirchmair, Rudolf, additional, Helbok, Raimund, additional, Prosch, Helmut, additional, Rieder, Dietmar, additional, Trajanoski, Zlatko, additional, Kronenberg, Florian, additional, Wöll, Ewald, additional, Weiss, Günter, additional, Widmann, Gerlig, additional, Löffler-Ragg, Judith, additional, and Tancevski, Ivan, additional

Published
2020
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28. Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial.

Author

Sonnweber T, Sahanic S, Pizzini A, Luger A, Schwabl C, Sonnweber B, Kurz K, Koppelstätter S, Haschka D, Petzer V, Boehm A, Aichner M, Tymoszuk P, Lener D, Theurl M, Lorsbach-Köhler A, Tancevski A, Schapfl A, Schaber M, Hilbe R, Nairz M, Puchner B, Hüttenberger D, Tschurtschenthaler C, Aßhoff M, Peer A, Hartig F, Bellmann R, Joannidis M, Gollmann-Tepeköylü C, Holfeld J, Feuchtner G, Egger A, Hoermann G, Schroll A, Fritsche G, Wildner S, Bellmann-Weiler R, Kirchmair R, Helbok R, Prosch H, Rieder D, Trajanoski Z, Kronenberg F, Wöll E, Weiss G, Widmann G, Löffler-Ragg J, and Tancevski I

Subjects
Humans, Lung diagnostic imaging, Prospective Studies, SARS-CoV-2, COVID-19, Pulmonary Fibrosis
Abstract

Background: After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking., Methods: In this prospective, multicentre, observational study, we systematically evaluated the cardiopulmonary damage in subjects recovering from COVID-19 at 60 and 100 days after confirmed diagnosis. We conducted a detailed questionnaire, clinical examination, laboratory testing, lung function analysis, echocardiography and thoracic low-dose computed tomography (CT)., Results: Data from 145 COVID-19 patients were evaluated, and 41% of all subjects exhibited persistent symptoms 100 days after COVID-19 onset, with dyspnoea being most frequent (36%). Accordingly, patients still displayed an impaired lung function, with a reduced diffusing capacity in 21% of the cohort being the most prominent finding. Cardiac impairment, including a reduced left ventricular function or signs of pulmonary hypertension, was only present in a minority of subjects. CT scans unveiled persisting lung pathologies in 63% of patients, mainly consisting of bilateral ground-glass opacities and/or reticulation in the lower lung lobes, without radiological signs of pulmonary fibrosis. Sequential follow-up evaluations at 60 and 100 days after COVID-19 onset demonstrated a vast improvement of symptoms and CT abnormalities over time., Conclusion: A relevant percentage of post-COVID-19 patients presented with persisting symptoms and lung function impairment along with radiological pulmonary abnormalities >100 days after the diagnosis of COVID-19. However, our results indicate a significant improvement in symptoms and cardiopulmonary status over time., Competing Interests: Conflict of interest: T. Sonnweber has nothing to disclose. Conflict of interest: S. Sahanic has nothing to disclose. Conflict of interest: A. Pizzini has nothing to disclose. Conflict of interest: A. Luger has nothing to disclose. Conflict of interest: C. Schwabl has nothing to disclose. Conflict of interest: B. Sonnweber has nothing to disclose. Conflict of interest: K. Kurz has nothing to disclose. Conflict of interest: S. Koppelstätter has nothing to disclose. Conflict of interest: D. Haschka has nothing to disclose. Conflict of interest: V. Petzer has nothing to disclose. Conflict of interest: A. Boehm has nothing to disclose. Conflict of interest: M. Aichner has nothing to disclose. Conflict of interest: P. Tymoszuk has nothing to disclose. Conflict of interest: D. Lener has nothing to disclose. Conflict of interest: M. Theurl has nothing to disclose. Conflict of interest: A. Lorsbach-Köhler has nothing to disclose. Conflict of interest: A. Tancevski has nothing to disclose. Conflict of interest: A. Schapfl has nothing to disclose. Conflict of interest: M. Schaber has nothing to disclose. Conflict of interest: R. Hilbe has nothing to disclose. Conflict of interest: M. Nairz has nothing to disclose. Conflict of interest: B. Puchner has nothing to disclose. Conflict of interest: D. Hüttenberger has nothing to disclose. Conflict of interest: C. Tschurtschenthaler has nothing to disclose. Conflict of interest: M. Aßhoff has nothing to disclose. Conflict of interest: A. Peer has nothing to disclose. Conflict of interest: F. Hartig has nothing to disclose. Conflict of interest: R. Bellmann has nothing to disclose. Conflict of interest: M. Joannidis has nothing to disclose. Conflict of interest: C. Gollmann-Tepeköylü has nothing to disclose. Conflict of interest: J. Holfeld has nothing to disclose. Conflict of interest: G. Feuchtner has nothing to disclose. Conflict of interest: A. Egger has nothing to disclose. Conflict of interest: G. Hoermann has nothing to disclose. Conflict of interest: A. Schroll has nothing to disclose. Conflict of interest: G. Fritsche has nothing to disclose. Conflict of interest: S. Wildner has nothing to disclose. Conflict of interest: R. Bellmann-Weiler has nothing to disclose. Conflict of interest: R. Kirchmair has nothing to disclose. Conflict of interest: R. Helbok has nothing to disclose. Conflict of interest: H. Prosch has nothing to disclose. Conflict of interest: D. Rieder has nothing to disclose. Conflict of interest: Z. Trajanoski has nothing to disclose. Conflict of interest: F. Kronenberg has nothing to disclose. Conflict of interest: E. Wöll has nothing to disclose. Conflict of interest: G. Weiss has nothing to disclose. Conflict of interest: G. Widmann has nothing to disclose. Conflict of interest: J. Löffler-Ragg has nothing to disclose. Conflict of interest: I. Tancevski reports an Investigator Initiated Study (IIS) grant from Boehringer Ingelheim (IIS 1199-0424)., (Copyright ©ERS 2021.)

Published
2021
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