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3. List of Contributors

Author

Acharya, Abhinav, primary, Ackun-Farmmer, Marian A., additional, Aggas, John R., additional, Andersen, Phillip J., additional, Anderson, James M., additional, Anseth, Kristi, additional, Archer, Paul A., additional, Ashammakhi, Nureddin, additional, Avila, Jose D., additional, Babensee, Julia E., additional, Badylak, Stephen f., additional, Baek, Kiheon, additional, Baker, Aaron B., additional, Bakht, Syeda Mahwish, additional, Bandyopadhyay, Amit, additional, Barchowsky, Aaron, additional, Bass, Garrett, additional, Becker, Matthew L., additional, Belleghem, Sarah Miho Van, additional, Benoit, Danielle S.W., additional, Biesiekierski, Arne, additional, Billiar, Kristen L., additional, Bose, Susmita, additional, Bowman, Christopher, additional, Boyce, Steven, additional, Brown, Bryan N., additional, Brown, Justin L., additional, Capadona, Jeffrey R., additional, Castner, David G., additional, Chang, Calvin, additional, Chang, Philip, additional, Chilkoti, Ashutosh, additional, Christman, Karen L., additional, Chung, Sangwon, additional, Coleman, Kelly P., additional, Conway, Dan, additional, Cook, Keith E., additional, Cooper, Stuart L., additional, Cosgriff-Hernandez, Elizabeth, additional, Coury, Arthur J., additional, Criscione, Joseph D., additional, Culver, Heidi, additional, Curtis, Jim, additional, Deng, Feiyang, additional, Dhavalikar, Prachi, additional, Diaz-Gomez, Luis, additional, Domingues, Rui M.A., additional, Duncan, Elaine, additional, Duran, Pamela, additional, Esbrit, Pedro, additional, Eskin, Suzanne G., additional, Esmail, Michael Y., additional, Ferracane, Jack L., additional, Fischbach, Claudia, additional, Fischman, Gary, additional, Fisher, John P., additional, Francolini, Iolanda, additional, Frey, Steven J., additional, Gaharwar, Akhilesh K., additional, García, Andrés J., additional, Gibson, Iain R., additional, Gilbert, Jeremy L., additional, Ginn, Brian, additional, Goldblatt, Zachary E., additional, Goldenberg, Seth J., additional, Gomes, Manuela E., additional, Gómez-Florit, Manuel, additional, Gonçalves, Inês C., additional, Gorbet, Maud B., additional, Grainger, David W., additional, Grody, Miles, additional, Guda, Teja, additional, Guelcher, Scott A., additional, Guiseppi-Elie, Anthony, additional, Hacking, S. Adam, additional, Hallab, Nadim James, additional, Hall-Stoodley, Luanne, additional, Hanson, Stephen R., additional, Han, Woojin M., additional, Harman, Melinda K., additional, Harrington, Roger, additional, Haschak, Martin J., additional, Heath, Daniel E., additional, Hicks, Emily Anne, additional, Hill, Ryan T., additional, Hoffman, Allan S., additional, Horbett, Thomas A., additional, Hubbell, Jeffrey A., additional, Ipek, Rasim, additional, Jacobs, Joshua J., additional, Jang, Young C., additional, Jiang, Shaoyi, additional, Johnson, Richard J., additional, Jones, Julian R., additional, Jo, Vickie Y., additional, Kane, Ravi S., additional, Kaplan, David L., additional, Kar, Ronit, additional, Keselowsky, Benjamin George, additional, Khademhosseini, Ali, additional, Kim, Yu Seon, additional, King, Martin W., additional, Kohane, Daniel S., additional, Kohn, David H., additional, Kuhn, Liisa T., additional, Kulkarni, Mangesh, additional, Kuo, Catherine K., additional, Lai, Angela, additional, Lambert, Bryron, additional, Lan, Ziyang, additional, Latour, Robert A., additional, Laurencin, Cato T., additional, Lawson, Bryan K., additional, Layland, Shannon Lee, additional, Lee, Jae Sung, additional, Lee-Parritz, David, additional, Lei, Ying, additional, Lemons, Jack E., additional, Levy, Robert J., additional, Lewerenz, Gregory M., additional, Lewis, Jamal S., additional, Liebscher, Simone, additional, Lin, Chien-Chi, additional, Livingston, Natalie K., additional, Li, Yang, additional, Li, Yuncang, additional, Lu, Helen, additional, Macdougall, Laura, additional, Mahadik, Bhushan, additional, Mamidwar, Sachin, additional, Manspeaker, Margaret P., additional, Mao, Hai-Quan, additional, Ma, Peter X., additional, Marcet, Tyler, additional, Martin, Jeffrey, additional, Martins, M. Cristina L., additional, McArthur, Sally L., additional, McGill, Meghan, additional, McIntire, Larry V., additional, Mei, Lei, additional, Mendes, Bárbara B., additional, Mikos, Antonios G., additional, Mitchell, Richard N., additional, Mitra, Indranath, additional, Muirhead, Ben, additional, Munir, Khurram, additional, Murphy, William L., additional, Nguyen, Phong K., additional, Nolfi, Alexis L., additional, Overby, Clyde, additional, Ozan, Sertan, additional, Padera, Robert F., additional, Pearce, Hannah A., additional, Peppas, Nicholas A., additional, Pereira, Andreia T., additional, Pfeifer, Carmem S., additional, Pinto, Artur M., additional, Raia, Nicole R., additional, Rankin, Edward A., additional, Ratner, Buddy D., additional, Regi, Maria Vallet, additional, Reis, Rui L., additional, Ritchie, Alastair Campbell, additional, Sakiyama-Elbert, Shelly E., additional, Salhadar, Karim, additional, Salinas, Antonio J., additional, Schenke-Layland, Katja, additional, Schoen, Frederick J., additional, Schutrum, Brittany E., additional, Sefton, Michael V., additional, Seidman, Michael A., additional, Shah, Darshan S., additional, Sheardown, Heather, additional, Shoffstall, Andrew J., additional, Simon, Carl G., additional, Simon, Josh, additional, Sims Jr., Kenneth R., additional, Slack, Steven M., additional, Slavin, Benjamin, additional, Snodderly, Kirstie Lane, additional, Stayton, Patrick S., additional, Steichen, Stephanie D., additional, Stoodley, Paul, additional, Swanson, W. Benton, additional, Tam, Hobey, additional, Tayab, Aftab, additional, Thomas, Susan N., additional, Traxel, Kellen D., additional, Tuan, Rocky S., additional, Tucker, Erik I., additional, Ukita, Rei, additional, Veith, Austin, additional, Vidal Yucha, Sarah E., additional, Viney, Christopher, additional, Vyavahare, Naren, additional, Wagner, William R., additional, Wang, Min, additional, Wang, Raymond M., additional, Warner, Petra, additional, Wen, Cuie, additional, West, Jennifer L., additional, Whitman, Matthew A., additional, Witte, Frank, additional, Wolf, Michael F., additional, Yao, Zhicheng, additional, Yaszemski, Michael, additional, Yaszemski, Michael J., additional, Yin, Lichen, additional, Zhang, Guigen, additional, Zhang, Peng, additional, Zhong, Zhiyuan, additional, and Ziats, Nicholas P., additional

Published
2020
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6. Endothelial cells metabolically regulate breast cancer invasion toward a microvessel.

Author

Tan, Matthew L., Jenkins-Johnston, Niaa, Huang, Sarah, Schutrum, Brittany, Vadhin, Sandra, Adhikari, Abhinav, Williams, Rebecca M., Zipfel, Warren R., Lammerding, Jan, Varner, Jeffrey D., and Fischbach, Claudia

Subjects
OXYGEN consumption, GLYCOLYSIS, ENDOTHELIAL cells, METASTATIC breast cancer, BREAST cancer, CELL metabolism, GLUCOSE metabolism
Abstract

Breast cancer metastasis is initiated by invasion of tumor cells into the collagen type I-rich stroma to reach adjacent blood vessels. Prior work has identified that metabolic plasticity is a key requirement of tumor cell invasion into collagen. However, it remains largely unclear how blood vessels affect this relationship. Here, we developed a microfluidic platform to analyze how tumor cells invade collagen in the presence and absence of a microvascular channel. We demonstrate that endothelial cells secrete pro-migratory factors that direct tumor cell invasion toward the microvessel. Analysis of tumor cell metabolism using metabolic imaging, metabolomics, and computational flux balance analysis revealed that these changes are accompanied by increased rates of glycolysis and oxygen consumption caused by broad alterations of glucose metabolism. Indeed, restricting glucose availability decreased endothelial cell-induced tumor cell invasion. Our results suggest that endothelial cells promote tumor invasion into the stroma due, in part, to reprogramming tumor cell metabolism. [ABSTRACT FROM AUTHOR]

Published
2023
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