1. Cardiac troponin and skeletal muscle oxygenation in severe post-partum haemorrhage
- Author
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Heyer, Laurent, Mebazaa, Alexandre, Gayat, Etienne, Resche-Rigon, Matthieu, Rabuel, Christophe, Rezlan, Eva, Lukascewicz, Anne-Claire, Madadaki, Catharina, Pirracchio, Romain, Schurando, Patrick, Morel, Olivier, Fargeaudou, Yann, and Payen, Didier
- Subjects
Medical Physiology ,Biomedical and Clinical Sciences ,Heart Disease ,Cardiovascular ,Clinical Research ,Adult ,Female ,Humans ,Muscle ,Skeletal ,Oxygen Consumption ,Postpartum Hemorrhage ,Pregnancy ,Spectroscopy ,Near-Infrared ,Troponin I ,Medical and Health Sciences ,Emergency & Critical Care Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
IntroductionCardiac troponin has been shown to be elevated in one-half of the parturients admitted for post-partum haemorrhage. The purpose of the study was to assess whether increased cardiac troponin was associated with a simultaneous alteration in haemoglobin tissue oxygen saturation in peripheral muscles in post-partum haemorrhage.MethodsTissue haemoglobin oxygen saturation of thenar eminence muscle (StO2) was measured via near-infrared spectroscopy technology. Two sets of StO2 parameters (both isolated baseline and during forearm ischaemia-reperfusion tests) were collected at two time points: upon intensive care unit admission and prior to intensive care unit discharge. Comparisons were performed using Wilcoxon paired tests, and univariate associations were assessed using logistic regression model and Wald tests.ResultsThe 42 studied parturients, admitted for post-partum haemorrhage, had clinical and biological signs of severe blood loss. Initial cardiac troponin I was increased in 24/42 parturients (0.43 +/- 0.60 microrg/l). All measured parameters of muscular haemoglobin oxygen saturation, including Srecovery, were also altered at admission and improved together with improved haemodynamics, when bleeding was controlled. Multivariate analysis showed that muscular Srecovery
- Published
- 2009