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3. Effect of the addition of a mental health specialist for evaluation of undiagnosed patients in centres for rare diseases (ZSE-DUO): a prospective, controlled trial with a two-phase cohort design

Author

Akkaya, Federica, Babka, Christine, Bannert, Lisa, Bärsch-Michelmann, Anja, Böhm, Leonie, Brinkmann, Folke, Bullinger, Monika, Cario, Holger, de Greck, Moritz, Debatin, Klaus-Michael, Dillmann-Jehn, Katrin, Eymann, Jutta, Frisch, Julia, Glode, Anja, Gödecke, Vega, Grasemann, Corinna, Grauer, Eva, Haas, Astrid, Haisch, Lea, Isabell, Heinrich, Held, Melissa, Hennermann, Julia, Herpertz, Stephan, Herrmann-Werner, Anne, Hett, Julian, Heuschmann, Peter, Hilbig, Bettina, Holthöfer, Laura, Imhof, Christiane, Junne, Florian, Kassubek, Jan, Koschitzki, Kevin-Thomas, Krassort, Heike, Kropff, Birgit, Kuhn, Julia, Latzko, Philipp, Loew, Thomas, Ludolph, Albert C., Meyer, Torsten, Meyer dos Santos, Isabell, Mohnike, Klaus, Monninger, Martina, Mücke, Martin, Müller, Susanne, Musacchio, Thomas, Nießen, Margret, Nöhre, Mariel, Ott, Stephan, Petermann-Meyer, Andrea, Pfeifer-Duck, Christina, Piduhn, Lea-Sophie, Rampp, Carina, Rieß, Olaf, Schaubert, Kristina, Schmidt, Annika, Schneider, Simone, Schoels, Ludger, Schwalba, Martina, Selig, Udo, Sroka, Alexandra, Steinbüchel, Toni, Stösser, Sebastian, Suchant, Steffi, Ungethüm, Kathrin, Vogel, Matthias, Volk, Daniela, Vollmuth, Christoph, Volnov, Solange, Wagner, Thomas O.F., Walter, Sabrina, Warrings, Bodo, Zajt, Kamil, Zenker, Karola, Zhang, David, Zipfel, Stephan, Hebestreit, Helge, Lapstich, Anne-Marie, Brandstetter, Lilly, Krauth, Christian, Deckert, Jürgen, Haas, Kirsten, Pfister, Lisa, Witt, Stefanie, Schippers, Christopher, Dieris-Hirche, Jan, Maisch, Tim, Tüscher, Oliver, Bârlescu, Lavinia Aurelia, Berger, Alexandra, Berneburg, Mark, Britz, Vanessa, Deibele, Anna, Graeßner, Holm, Gündel, Harald, Heuft, Gereon, Lücke, Thomas, Mundlos, Christine, Quitmann, Julia Hannah, Rutsch, Frank, Schubert, Katharina, Schulz, Jörg B., Schweiger, Susann, Zeidler, Cornelia, Zeltner, Lena Margarete, de Zwaan, Martina, Bârlescu, Lavinia, Quitmann, Julia, Schulz, Jörg Bernhard, and Zeltner, Lena

Published
2023
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4. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial

Author

Alonso, Angelika, Arquizan, Caroline, Barreau, Xavier, Beaujeux, Rémy, Behme, Daniel, Boeckh-Behrens, Tobias, Boehme, Christian, Boix, Martí, Boulouis, Grégoire, Bricout, Nicolas, Broc, Nicolas, Cereda, Carlo W., Chabert, Emmanuel, Cho, Tae-Hee, Cianfoni, Alessandro, Costalat, Vincent, Denier, Christian, Di Maria, Frederico, du Mesnil de Rochemont, Richard, Fearon, Patricia, Ferrier, Anna, Fischer, Sebastian, Gauberti, Maxime, Gaudron, Marie, Gimenez, Laetitia, Globas, Christoph, Görtler, Michael, Goyal, Mayank, Hilker-Roggendorf, Ruediger, Hill, Michael D., Hua, Vi Tuan, Humbertjean, Lisa, Jansen, Olav, Jung, Simon, Kägi, Georg, Kelly, Michael E., Kleffner, Ilka, Knoflach, Michael, Nedeltchev, Krassen, Krause, Lars Udo, Lappalainen, Kimmo, Lefebvre, Margaux, Leyon, Joe, Liao, Liang, Liegey, Jean-Sebastien, Loehr, Christian, Michel, Patrik, Nannoni, Stefania, Nicholson, Patrick, Nico, Lorena, Obadia, Michael, Ognard, Julien, Ogungbemi, Ayokunle, Olivot, Jean-Marc, Escalard, Simon, Pasi, Marco, Peeling, Lissa, Perez, Jane, Petersen, Martina, Piechowiak, Eike, Raposo, Roberto, Räty, Silja, Reitz, Sarah C., Remollo, Sebastià, Remonda, Luca, Rennie, Ian, Requena, Manuel, Riabikin, Alexander, Riva, Roberto, Rouchaud, Aymeric, Rosi, Andrea, Rubiera, Marta, Spelle, Laurent, Schnieder, Marlena, Schaafsma, Joanna D., Schubert, Tilman, Schulz, Jörg B., Siddiqui, Mohammed, Soize, Sébastien, Sonnberger, Michael, Touze, Emmanuel, Triquenot, Aude, Turc, Guillaume, Vieira, Lucy, Ben Hassen, Wagih, Wagner, Judith N., Wasser, Katrin, Weber, Johannes, Wenz, Holger, Weisenburger-Lile, David, Wodarg, Fritz, Wolff, Valérie, Wunderlich, Silke, Fischer, Urs, Kaesmacher, Johannes, Strbian, Daniel, Eker, Omer, Cognard, Christoph, Plattner, Patricia S, Bütikofer, Lukas, Mordasini, Pasquale, Deppeler, Sandro, Pereira, Vitor M, Albucher, Jean François, Darcourt, Jean, Bourcier, Romain, Benoit, Guillon, Papagiannaki, Chrysanthi, Ozkul-Wermester, Ozlem, Sibolt, Gerli, Tiainen, Marjaana, Gory, Benjamin, Richard, Sébastien, Liman, Jan, Ernst, Marielle Sophie, Boulanger, Marion, Barbier, Charlotte, Mechtouff, Laura, Zhang, Liqun, Marnat, Gaultier, Sibon, Igor, Nikoubashman, Omid, Reich, Arno, Consoli, Arturo, Lapergue, Bertrand, Ribo, Marc, Tomasello, Alejandro, Saleme, Suzana, Macian, Francisco, Moulin, Solène, Pagano, Paolo, Saliou, Guillaume, Carrera, Emmanuel, Janot, Kevin, Hernández-Pérez, María, Pop, Raoul, Schiava, Lucie Della, Luft, Andreas R, Piotin, Michel, Gentric, Jean Christophe, Pikula, Aleksandra, Pfeilschifter, Waltraud, Arnold, Marcel, Siddiqui, Adnan H, Froehler, Michael T, Furlan, Anthony J, Chapot, René, Wiesmann, Martin, Machi, Paolo, Diener, Hans-Christoph, Kulcsar, Zsolt, Bonati, Leo H, Bassetti, Claudio L, Mazighi, Mikael, Liebeskind, David S, Saver, Jeffrey L, and Gralla, Jan

Published
2022
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10. A new CERAD total score with equally weighted z-scores and additional executive and non-amnestic „CERAD-Plus“ tests enhances cognitive diagnosis in patients with Parkinson's disease: Evidence from the LANDSCAPE study

Author

Lillig, Robert, Ophey, Anja, Schulz, Jörg B., Reetz, Kathrin, Wojtala, Jennifer, Storch, Alexander, Liepelt-Scarfone, Inga, Becker, Sara, Berg, Daniela, Balzer-Geldsetzer, Monika, Kassubek, Jan, Hilker-Roggendorf, Rüdiger, Witt, Karsten, Mollenhauer, Brit, Trenkwalder, Claudia, Roeske, Sandra, Wittchen, Hans-Ullrich, Riedel, Oliver, Dodel, Richard, and Kalbe, Elke

Published
2021
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11. Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 4-year cohort study

Author

Labrum, Robyn, Thomas-Black, Gilbert, Manso, Katarina, Solanky, Nita, Gellera, Cinzia, Mongelli, Alessia, Castaldo, Anna, Fichera, Mario, Palau, Francesc, O'Callaghan, Mar, Biet, Marie, Monin, Marie Lorraine, Eigentler, Andreas, Indelicato, Elisabetta, Amprosi, Matthias, Radelfahr, Florentine, Bischoff, Almut T., Holtbernd, Florian, Brcina, Nikolina, Hohenfeld, Christian, Koutsis, Georgios, Breza, Marianthi, Bertini, Enrico, Vasco, Gessica, Reetz, Kathrin, Dogan, Imis, Hilgers, Ralf-Dieter, Giunti, Paola, Parkinson, Michael H, Mariotti, Caterina, Nanetti, Lorenzo, Durr, Alexandra, Ewenczyk, Claire, Boesch, Sylvia, Nachbauer, Wolfgang, Klopstock, Thomas, Stendel, Claudia, Rodríguez de Rivera Garrido, Francisco Javier, Rummey, Christian, Schöls, Ludger, Hayer, Stefanie N, Klockgether, Thomas, Giordano, Ilaria, Didszun, Claire, Rai, Myriam, Pandolfo, Massimo, and Schulz, Jörg B

Published
2021
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13. Conversion of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 to manifest ataxia (RISCA): a longitudinal cohort study

Author

Jacobi, Heike, du Montcel, Sophie Tezenas, Romanzetti, Sandro, Harmuth, Florian, Mariotti, Caterina, Nanetti, Lorenzo, Rakowicz, Maria, Makowicz, Grzegorz, Durr, Alexandra, Monin, Marie-Lorraine, Filla, Alessandro, Roca, Alessandro, Schöls, Ludger, Hengel, Holger, Infante, Jon, Kang, Jun-Suk, Timmann, Dagmar, Casali, Carlo, Masciullo, Marcella, Baliko, Laszlo, Melegh, Bela, Nachbauer, Wolfgang, Bürk-Gergs, Katrin, Schulz, Jörg B, Riess, Olaf, Reetz, Kathrin, and Klockgether, Thomas

Published
2020
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15. Psychometric Properties of an Abbreviated Version of the Apathy Evaluation Scale for Parkinson Disease (AES-12PD)

Author

Stankevich, Yuliya, Lueken, Ulrike, Balzer-Geldsetzer, Monika, Dodel, Richard, Gräber-Sultan, Susanne, Berg, Daniela, Liepelt-Scarfone, Inga, Hilker-Roggendorf, Rüdiger, Kalbe, Elke, Kaut, Oliver, Mollenhauer, Brit, Reetz, Kathrin, Schäffer, Eva, Schmidt, Nele, Schulz, Jörg B., Spottke, Annika, Witt, Karsten, Linse, Katharina, Storch, Alexander, and Riedel, Oliver

Published
2018
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16. Survival in patients with spinocerebellar ataxia types 1, 2, 3, and 6 (EUROSCA): a longitudinal cohort study

Author

Diallo, Alhassane, Jacobi, Heike, Cook, Arron, Labrum, Robyn, Durr, Alexandra, Brice, Alexis, Charles, Perrine, Marelli, Cecilia, Mariotti, Caterina, Nanetti, Lorenzo, Panzeri, Marta, Rakowicz, Maria, Sobanska, Anna, Sulek, Anna, Schmitz-Hübsch, Tanja, Schöls, Ludger, Hengel, Holger, Melegh, Bela, Filla, Alessandro, Antenora, Antonella, Infante, Jon, Berciano, José, van de Warrenburg, Bart P, Timmann, Dagmar, Boesch, Sylvia, Pandolfo, Massimo, Schulz, Jörg B, Bauer, Peter, Giunti, Paola, Kang, Jun-Suk, Klockgether, Thomas, and Tezenas du Montcel, Sophie

Published
2018
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23. Demenzen

Author

Wolf, Stefanie, Schulz, Jörg B., Karnath, Hans-Otto, editor, and Thier, Peter, editor

Published
2012
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24. Author Correction: Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial

Author

Dam, Tien, Boxer, Adam L, Yang, Lili, Shill, Holly, Shprecher, David, Stamelou, Maria, Steiger, Malcolm, Takahashi, Yuji, Takigawa, Hiroshi, Tartaglia, Carmela, Toenges, Lars, Truong, Daniel, Tse, Winona, Tidemann-Miller, Beth, Tuite, Paul, Volc, Dieter, Wills, Anne-Marie A, Woitalla, Dirk, Xie, Tao, Yuasa, Tatsuhiko, Zauber, Sarah Elizabeth, Zesiewicz, Theresa, Kupferman, Joseph, Harper, Kristine, Kamisoglu, Kubra, Wald, Michael J, Graham, Danielle L, Gedney, Liz, O'Gorman, John, Haeberlein, Samantha Budd, Golbe, Lawrence I, Group, PASSPORT Study, Aiba, Ikuko, Antonini, Angelo, Apetauerova, Diana, Azulay, Jean-Philippe, Martinez, Ernest Balaguer, Bang, Jee, Barone, Paolo, Barrett, Matthew, Bega, Danny, Höglinger, Günter, Berg, Daniela, Corrales, Koldo Berganzo, Bordelon, Yvette, Brandt, Moritz, Brueggemann, Norbert, Castelnovo, Giovanni, Ceravolo, Roberto, Chuang, Rosalind, Chung, Sun Ju, Morris, Huw R, Church, Alistair, Corvol, Jean-Christophe, Cudia, Paola, Dale, Marian, Defebvre, Luc, Drapier, Sophie, Driver-Dunckley, Erika D, Ebersbach, Georg, Eggert, Karla M, Ellenbogen, Aaron, Litvan, Irene, Eusebio, Alexandre, Evans, Andrew H, Fedorova, Natalia, Finger, Elizabeth, Foubert-Samier, Alexandra, Ghosh, Boyd, Golbe, Lawrence, Perez, Francisco Grandas, Grossman, Murray, Hall, Deborah, Lang, Anthony E, Hamada, Kyoko, Hasegawa, Kazuko, Hoeglinger, Guenter, Honig, Lawrence, Houghton, David, Huang, Xuemei, Isaacson, Stuart, Koh, SeongBeom, Bojarski, Jaime Kulisevsky, Leigh, Peter Nigel, Lozano, Juan Jose Lopez, Moreno, Jose Luis Lopez-Sendon, Ludolph, Albert Christian, Piudo, Ma Rosario Luquin, Torres, Irene Martinez, McFarland, Nikolaus, Meissner, Wassilios, Mestre, Tiago, Rivera, Pablo Mir, Molho, Eric, Mollenhauer, Britt, Murata, Miho, Obi, Tomokazu, Magne, Fabienne Ory, O'Suilleabhain, Padraig, Pahwa, Rajesh, Pantelyat, Alexander, Grundman, Michael, Pavese, Nicola, Pokhabov, Dmitry, Prudlo, Johannes, Rodriguez-Porcel, Federico, Rowe, James, Savitt, Joseph, Schnitzler, Alfons, Schulz, Joerg B, Seppi, Klaus, and Shah, Binit

Subjects
ddc:610, General Medicine, General Biochemistry, Genetics and Molecular Biology
Published
2022

26. Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data

Author

Jacobi, Heike, Reetz, Kathrin, du Montcel, Sophie Tezenas, Bauer, Peter, Mariotti, Caterina, Nanetti, Lorenzo, Rakowicz, Maria, Sulek, Anna, Durr, Alexandra, Charles, Perrine, Filla, Alessandro, Antenora, Antonella, Schöls, Ludger, Schicks, Julia, Infante, Jon, Kang, Jun-Suk, Timmann, Dagmar, Fabio, Roberto Di, Masciullo, Marcella, Baliko, Laszlo, Melegh, Bela, Boesch, Sylvia, Bürk, Katrin, Peltz, Annkathrin, Schulz, Jörg B, Dufaure-Garé, Isabelle, and Klockgether, Thomas

Published
2013
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29. The Cost of Early Diagnosis of Cognitive Decline in German Memory Clinics

Author

Onurl, Oezguer A., Wolff-Menzler, Claus, von Arnim, Christine A. F., Jessen, Frank, Fink, Gereon R., Wiltfang, Jens, Laske, Christoph, Schneider, Anja, Levinl, Johannes, Oberstein, Timo, Kornhuber, Johannes, Oberhauser, Felix, Gallinat, Juergen, Dodel, Richard, Otto, Markus, Peters, Oliver, Teipel, Stefan, DuezeI, Emrah, Riemenschneider, Matthias, Floeel, Agnes, Perneczk, Robert, Reetz, Kathrin, Schulz, Joerg B., Hausner, Lucrezia, Grimmer, Timo, Froelich, Lutz, Onurl, Oezguer A., Wolff-Menzler, Claus, von Arnim, Christine A. F., Jessen, Frank, Fink, Gereon R., Wiltfang, Jens, Laske, Christoph, Schneider, Anja, Levinl, Johannes, Oberstein, Timo, Kornhuber, Johannes, Oberhauser, Felix, Gallinat, Juergen, Dodel, Richard, Otto, Markus, Peters, Oliver, Teipel, Stefan, DuezeI, Emrah, Riemenschneider, Matthias, Floeel, Agnes, Perneczk, Robert, Reetz, Kathrin, Schulz, Joerg B., Hausner, Lucrezia, Grimmer, Timo, and Froelich, Lutz

Abstract

Dementias are expensive diseases: the net annual cost in European healthcare is about euro 28.000 per case with a strong stage dependency, of which medical care accounts for about 19%. Diagnostic costs, on the other hand, account for only a small proportion of the total costs. With changes in the guidelines, biomarker tests are becoming increasingly important. At present, the concrete economic impact of biomarker-based diagnosis is largely unknown. To determine the actual costs of diagnostic procedures based on guidelines, we conducted a survey among the members of the German Memory Clinic Network (DNG). From 15 expert centres, the staff engagement time for all procedures was collected. Based on the individual engagement times of the different professions, the total of personnel costs for diagnostics was calculated using current gross personnel costs. The total sum of diagnostic costs (personnel plus procedures) was calculated for three different scenarios e. g. euro 633,97 for diagnostics without biomarkers, euro 1.214,90 for diagnostics with CSF biomarkers and euro 4.740,58 euro for diagnostics with FDG- plus Amyloid-PET. In addition, the actual diagnostic costs of the current practice in expert memory clinics were estimated, taking into account personnel costs, costs for the different procedures and the frequency of their use across all patients. This results in total average costs of euro 1.394,43 per case as the mean across all centres (personnel costs euro 351,72, costs for diagnostic procedures euro 1.042,71). The results show that state-of-the-art diagnosis of dementia and pre-dementia states, such as mild cognitive impairment (MCI) requires financial resources, which are currently not fully reimbursed in Germany. The need for a biomarker-based etiological diagnosis of dementia and pre-dementia states will increase, due to availability of disease-modifying treatments. Therefore, the current gap of reimbursement must be filled by new models of compensation.

Published
2022

39. Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6

Author

Schulz, Jörg B., Borkert, Johannes, Wolf, Stefanie, Schmitz-Hübsch, Tanja, Rakowicz, Maryla, Mariotti, Caterina, Schoels, Ludger, Timmann, Dagmar, van de Warrenburg, Bart, Dürr, Alexandra, Pandolfo, Massimo, Kang, Jun-Suk, Mandly, Andrés González, Nägele, Thomas, Grisoli, Marina, Boguslawska, Romana, Bauer, Peter, Klockgether, Thomas, and Hauser, Till-Karsten

Published
2010
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40. Changes in brain activation related to visuo-spatial memory after real-time fMRI neurofeedback training in healthy elderly and Alzheimer's disease

Author

Hohenfeld, Christian, Kuhn, Hanna, Mueller, Christine, Nellessen, Nils, Ketteler, Simon, Heinecke, Armin, Goebel, Rainer, Shah, N. Jon, Schulz, Joerg B., Reske, Martina, Reetz, Kathrin, Hohenfeld, Christian, Kuhn, Hanna, Mueller, Christine, Nellessen, Nils, Ketteler, Simon, Heinecke, Armin, Goebel, Rainer, Shah, N. Jon, Schulz, Joerg B., Reske, Martina, and Reetz, Kathrin

Abstract

Cognitive decline is a symptom of healthy ageing and Alzheimer's disease. We examined the effect of real-time fMRI based neurofeedback training on visuo-spatial memory and its associated neuronal response. Twelve healthy subjects and nine patients of prodromal Alzheimer's disease were included. The examination spanned five days (T1-T5): T1 contained a neuropsychological pre-test, the encoding of an itinerary and a fMRI-based task related that itinerary. T2-T4 hosted the real-time fMRI neurofeedback training of the parahippocampal gyrus and on T5 a post-test session including encoding of another itinerary and a subsequent fMRIbased task were done. Scores from neuropsychological tests, brain activation and task performance during the fMRI-paradigm were compared between pre and post-test as well as between healthy controls and patients. Behavioural performance in the fMRI-task remained unchanged, while cognitive testing showed improvements in visuo-spatial memory performance. Both groups displayed task-relevant brain activation, which decreased in the right precentral gyrus and left occipital lobe from pre to post-test in controls, but increased in the right occipital lobe, middle frontal gyrus and left frontal lobe in the patient group. While results suggest that the training has affected brain activation differently between controls and patients, there are no pointers towards a behavioural manifestation of these changes. Future research is required on the effects that can be induced using real-time fMRI based neurofeedback training and the required training duration to elicit broad and lasting effects.

Published
2020

43. Cognitive decline in Parkinson's disease: the impact of the motor phenotype on cognition

Author

Wojtala, Jennifer, Heber, Ines Ann, Neuser, Petra, Heller, Julia, Kalbe, Elke, Rehberg, Sarah P., Storch, Alexander, Linse, Katharina, Schneider, Christine, Graeber, Susanne, Berg, Daniela, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker-Roggendorf, Rudiger, Oberschmidt, Carola, Baudrexel, Simon, Witt, Karsten, Schmidt, Nele, Deuschl, Guenther, Mollenhauer, Brit, Trenkwalder, Claudia, Liepelt-Scarfone, Inga, Spottke, Annika, Roeske, Sandra, Wuellner, Ullrich, Wittchen, Hans-Ulrich, Riedel, Oliver, Dodel, Richard, Schulz, Joerg B., Reetz, Kathrin, Wojtala, Jennifer, Heber, Ines Ann, Neuser, Petra, Heller, Julia, Kalbe, Elke, Rehberg, Sarah P., Storch, Alexander, Linse, Katharina, Schneider, Christine, Graeber, Susanne, Berg, Daniela, Dams, Judith, Balzer-Geldsetzer, Monika, Hilker-Roggendorf, Rudiger, Oberschmidt, Carola, Baudrexel, Simon, Witt, Karsten, Schmidt, Nele, Deuschl, Guenther, Mollenhauer, Brit, Trenkwalder, Claudia, Liepelt-Scarfone, Inga, Spottke, Annika, Roeske, Sandra, Wuellner, Ullrich, Wittchen, Hans-Ulrich, Riedel, Oliver, Dodel, Richard, Schulz, Joerg B., and Reetz, Kathrin

Abstract

Objectives Parkinson's disease (PD) is the second most common neurodegenerative disorder and is further associated with progressive cognitive decline. In respect to motor phenotype, there is some evidence that akinetic-rigid PD is associated with a faster rate of cognitive decline in general and a greater risk of developing dementia. The objective of this study was to examine cognitive profiles among patients with PD by motor phenotypes and its relation to cognitive function. Methods Demographic, clinical and neuropsychological cross-sectional baseline data of the DEMPARK/LANDSCAPE study, a multicentre longitudinal cohort study of 538 patients with PD were analysed, stratified by motor phenotype and cognitive syndrome. Analyses were performed for all patients and for each diagnostic group separately, controlling for age, gender, education and disease duration. Results Compared with the tremor-dominant phenotype, akinetic-rigid patients performed worse in executive functions such as working memory (Wechsler Memory Scale-Revised backward; p= 0.012), formallexical word fluency (p= 0.043), card sorting (p= 0.006), attention (Trail Making Test version A; p= 0.024) and visuospatial abilities (Leistungsprufungssystem test 9; p= 0.006). Akinetic-rigid neuropsychological test scores for the executive and attentive domain correlated negatively with non-tremor motor scores. Covariate-adjusted binary logistic regression analyses showed significant odds for PD-mild cognitive impairment for not-determined as compared with tremor-dominant (OR= 3.198) and akinetic-rigid PD (OR= 2.059). The odds for PD-dementia were significant for akinetic-rigid as compared with tremor-dominant phenotype (OR= 8.314). Conclusion The three motor phenotypes of PD differ in cognitive performance, showing that cognitive deficits seem to be less severe in tremor-dominant PD. While these data are cross-sectional, longitudinal data are needed to shed more light on these differential findings.

Published
2019

44. No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

Author

Hopfner, Franziska, Mueller, Stefanie H., Steppat, Dagmar, Miller, Joanna, Schmidt, Nele, Wandinger, Klaus-Peter, Leypoldt, Frank, Berg, Daniela, Franke, Andre, Lieb, Wolfgang, Tittmann, Lukas, Balzer-Geldsetzer, Monika, Baudrexel, Simon, Dodel, Richard, Hilker-Roggendorf, Ruediger, Kalbe, Elke, Kassubek, Jan, Klockgether, Thomas, Liepelt-Scarfone, Inga, Mollenhauer, Brit, Neuser, Petra, Reetz, Kathrin, Riedel, Oliver, Schulte, Claudia, Schulz, Joerg B., Spottke, Annika, Storch, Alexander, Trenkwalder, Claudia, Wittchen, Hans-Ulrich, Witt, Karsten, Wuellner, Ullrich, Deuschl, Gunther, Kuhlenbaeumer, Gregor, Hopfner, Franziska, Mueller, Stefanie H., Steppat, Dagmar, Miller, Joanna, Schmidt, Nele, Wandinger, Klaus-Peter, Leypoldt, Frank, Berg, Daniela, Franke, Andre, Lieb, Wolfgang, Tittmann, Lukas, Balzer-Geldsetzer, Monika, Baudrexel, Simon, Dodel, Richard, Hilker-Roggendorf, Ruediger, Kalbe, Elke, Kassubek, Jan, Klockgether, Thomas, Liepelt-Scarfone, Inga, Mollenhauer, Brit, Neuser, Petra, Reetz, Kathrin, Riedel, Oliver, Schulte, Claudia, Schulz, Joerg B., Spottke, Annika, Storch, Alexander, Trenkwalder, Claudia, Wittchen, Hans-Ulrich, Witt, Karsten, Wuellner, Ullrich, Deuschl, Gunther, and Kuhlenbaeumer, Gregor

Abstract

Background: IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without dementia produced conflicting results. We measured NMDA antibodies in a large, well phenotyped sample of Parkinson patients without and with cognitive impairment (n = 296) and controls (n = 295) free of neuropsychiatric disease. Detailed phenotyping and large numbers allowed statistically meaningful correlation of antibody status with diagnostic subgroups as well as quantitative indicators of disease severity and cognitive impairment. Methods: NMDA antibodies were analysed in the serum of patients and controls using well established validated assays. We used anti-NMDA antibody positivity as the main independent variable and correlated it with disease status and phenotypic characteristics. Results: The frequency of NMDA IgA/IgM antibodies was lower in Parkinson patients (13%) than in controls (22%) and higher than in previous studies in both groups. NMDA IgA/IgM antibodies were neither significantly associated with diagnostic subclasses of Parkinson disease according to cognitive impairment, nor with quantitative indicators of disease severity and cognitive impairment A positive NMDA antibody status was positively correlated with age in controls but not in Parkinson patients. Conclusion: It is unlikely albeit not impossible that NMDA antibodies play a significant role in the pathogenesis or progression of Parkinson disease e.g. to Parkinson disease with dementia, while NMDA IgG antibodies define a separate disease of its own.

Published
2019

47. Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

Author

Beier Christoph P, Schulz Joerg B, and Beier Dagmar

Subjects
glioblastoma, cancer stem cell, temozolomide, chemoresistance, BCNU, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Glioblastomas (GBM) are a paradigm for the investigation of cancer stem cells (CSC) in solid malignancies. The susceptibility of GBM CSC to standard chemotherapeutic drugs is controversial as the existing literature presents conflicting experimental data. Here, we summarize the experimental evidence on the resistance of GBM CSC to alkylating chemotherapeutic agents, with a special focus on temozolomide (TMZ). The data suggests that CSC are neither resistant nor susceptible to chemotherapy per se. Detoxifying proteins such as O6-methylguanine-DNA-methyltransferase (MGMT) confer a strong intrinsic resistance to CSC in all studies. Extrinsic factors may also contribute to the resistance of CSC to TMZ. These may include TMZ concentrations in the brain parenchyma, TMZ dosing schemes, hypoxic microenvironments, niche factors, and the re-acquisition of stem cell properties by non-stem cells. Thus, the interaction of CSC and chemotherapy is more complex than may be expected and it is necessary to consider these factors in order to overcome chemoresistance in the patient.

Published
2011
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