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24 results on '"Schultze, Robert L."'

1. Lacripep for the Treatment of Primary Sjögren–Associated Ocular Surface Disease: Results of the First-In-Human Study

Author

Tauber, Joseph, Laurie, Gordon W., Parsons, Edward C., Odrich, Marc G., Abrams, Marc A., Asbell, Penny A., Berdy, Gregg J., Bergstrom, Lance K., Bowden, Frank W., III, Bower, Kraig S., Boyce, James D., DaVanzo, Robert J., El-Harazi, Lugene, Epitropoulos, Alice T., Forstot, S. Lance, Goldberg, Damien F., Greiner, Jack V., Haider, Kathryn M., Hardten, David R., Hauswirth, Scott G., Hom, Milton M., Kelley, Kathleen A., Khachikian, Stephen S., Kim, Jennifer L., Majmudar, Parag A., Martel, Joseph R., Massaro-Giordano, Giacomina, McGehee, Tara W., McNamara, Nancy A., Meyer, John C., Nichols, Kelly K., Perez, Bernard R., Rubin, Mark S., Sall, Kenneth, Schultze, Robert L., Schwartz, Jay L., Segal, Bruce, Sheppard, John D., Tauber, Joseph, Thompson, Vance M., Tims, Joseph S., and Van, Da-Thuy

Published
2023
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5. The Effect of Donor Age on Penetrating Keratoplasty for Endothelial Disease Graft Survival after 10 Years in the Cornea Donor Study

Author

Group, Writing Committee for the Cornea Donor Study Research, Mannis, Mark J, Holland, Edward J, Gal, Robin L, Dontchev, Mariya, Kollman, Craig, Raghinaru, Dan, Dunn, Steven P, Schultze, Robert L, Verdier, David D, Lass, Jonathan H, Raber, Irving M, Sugar, Joel, Gorovoy, Mark S, Sugar, Alan, Stulting, R Doyle, Montoya, Monty M, Penta, Jeffrey G, Benetz, Beth Ann, and Beck, Roy W

Subjects
Eye Disease and Disorders of Vision, Clinical Trials and Supportive Activities, Transplantation, Clinical Research, Eye, Adolescent, Adult, Age Factors, Aged, Aging, Child, Corneal Edema, Double-Blind Method, Eye Banks, Female, Follow-Up Studies, Fuchs' Endothelial Dystrophy, Graft Survival, Humans, Keratoplasty, Penetrating, Male, Middle Aged, Prospective Studies, Registries, Tissue Donors, Young Adult, Writing Committee for the Cornea Donor Study Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry
Abstract

ObjectiveTo determine whether the 10-year success rate of penetrating keratoplasty for corneal endothelial disorders is associated with donor age.DesignMulticenter, prospective, double-masked clinical trial.ParticipantsA total of 1090 participants undergoing penetrating keratoplasty at 80 sites for Fuchs' dystrophy (62%), pseudophakic/aphakic corneal edema (34%), or another corneal endothelial disorder (4%) and followed for up to 12 years.MethodsForty-three eye banks provided corneas from donors aged 12 to 75 years, using a randomized approach to assign donor corneas to study participants without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons' usual routines.Main outcome measuresGraft failure defined as a regraft or, in the absence of a regraft, a cloudy cornea that was sufficiently opaque to compromise vision for 3 consecutive months.ResultsIn the primary analysis, the 10-year success rate was 77% for 707 corneas from donors aged 12 to 65 years compared with 71% for 383 donors aged 66 to 75 years (difference, +6%; 95% confidence interval, -1 to +12; P = 0.11). When analyzed as a continuous variable, higher donor age was associated with lower graft success beyond the first 5 years (P

Published
2013

12. Donor, Recipient, and Operative Factors Associated With Increased Endothelial Cell Loss in the Cornea Preservation Time Study.

Author

Lass, Jonathan H., Benetz, Beth Ann, Patel, Sanjay V., Szczotka-Flynn, Loretta B., O'Brien, Robert, Ayala, Allison R., Maguire, Maureen G., Daoud, Yassine J., Greiner, Mark A., Hannush, Sadeer B., Lee, W. Barry, Mauger, Thomas F., Menegay, Harry J., Mifflin, Mark D., Raizman, Michael B., Rose-Nussbaumer, Jennifer, Schultze, Robert L., Schmidt, Gregory A., Sugar, Alan, and Terry, Mark A.

Published
2019
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13. The effect of donor age on penetrating keratoplasty for endothelial disease: graft survival after 10 years in the Cornea Donor Study

Author

Writing Committee for the Cornea Donor Study Research Group, Mannis, Mark J, Holland, Edward J, Gal, Robin L, Dontchev, Mariya, Kollman, Craig, Raghinaru, Dan, Dunn, Steven P, Schultze, Robert L, Verdier, David D, Lass, Jonathan H, Raber, Irving M, Sugar, Joel, Gorovoy, Mark S, Sugar, Alan, Stulting, R Doyle, Montoya, Monty M, Penta, Jeffrey G, Benetz, Beth Ann, and Beck, Roy W

Subjects
Adult, Male, Aging, Adolescent, Clinical Trials and Supportive Activities, Clinical Sciences, Eye Banks, Eye, Ophthalmology & Optometry, Writing Committee for the Cornea Donor Study Research Group, Young Adult, Penetrating, Double-Blind Method, Clinical Research, Opthalmology and Optometry, Humans, Registries, Prospective Studies, Child, Eye Disease and Disorders of Vision, Aged, Transplantation, Fuchs' Endothelial Dystrophy, Corneal Edema, Graft Survival, Age Factors, Middle Aged, Tissue Donors, Keratoplasty, Public Health and Health Services, Female, Follow-Up Studies
Abstract

ObjectiveTo determine whether the 10-year success rate of penetrating keratoplasty for corneal endothelial disorders is associated with donor age.DesignMulticenter, prospective, double-masked clinical trial.ParticipantsA total of 1090 participants undergoing penetrating keratoplasty at 80 sites for Fuchs' dystrophy (62%), pseudophakic/aphakic corneal edema (34%), or another corneal endothelial disorder (4%) and followed for up to 12 years.MethodsForty-three eye banks provided corneas from donors aged 12 to 75 years, using a randomized approach to assign donor corneas to study participants without respect to recipient factors. Surgery and postoperative care were performed according to the surgeons' usual routines.Main outcome measuresGraft failure defined as a regraft or, in the absence of a regraft, a cloudy cornea that was sufficiently opaque to compromise vision for 3 consecutive months.ResultsIn the primary analysis, the 10-year success rate was 77% for 707 corneas from donors aged 12 to 65 years compared with 71% for 383 donors aged 66 to 75 years (difference, +6%; 95% confidence interval, -1 to +12; P = 0.11). When analyzed as a continuous variable, higher donor age was associated with lower graft success beyond the first 5 years (P

Published
2013

15. The Effect of Donor Age on Penetrating Keratoplasty for Endothelial Disease

Author

Mannis, Mark J., primary, Holland, Edward J., additional, Gal, Robin L., additional, Dontchev, Mariya, additional, Kollman, Craig, additional, Raghinaru, Dan, additional, Dunn, Steven P., additional, Schultze, Robert L., additional, Verdier, David D., additional, Lass, Jonathan H., additional, Raber, Irving M., additional, Sugar, Joel, additional, Gorovoy, Mark S., additional, Sugar, Alan, additional, Stulting, R. Doyle, additional, Montoya, Monty M., additional, Penta, Jeffrey G., additional, Benetz, Beth Ann, additional, and Beck, Roy W., additional

Published
2013
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16. Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error

Author

Cheng, Ching-Yu, primary, Schache, Maria, additional, Ikram, M. Kamran, additional, Young, Terri L., additional, Guggenheim, Jeremy A., additional, Vitart, Veronique, additional, MacGregor, Stuart, additional, Verhoeven, Virginie J.M., additional, Barathi, Veluchamy A., additional, Liao, Jiemin, additional, Hysi, Pirro G., additional, Bailey-Wilson, Joan E., additional, St. Pourcain, Beate, additional, Kemp, John P., additional, McMahon, George, additional, Timpson, Nicholas J., additional, Evans, David M., additional, Montgomery, Grant W., additional, Mishra, Aniket, additional, Wang, Ya Xing, additional, Wang, Jie Jin, additional, Rochtchina, Elena, additional, Polasek, Ozren, additional, Wright, Alan F., additional, Amin, Najaf, additional, van Leeuwen, Elisabeth M., additional, Wilson, James F., additional, Pennell, Craig E., additional, van Duijn, Cornelia M., additional, de Jong, Paulus T.V.M., additional, Vingerling, Johannes R., additional, Zhou, Xin, additional, Chen, Peng, additional, Li, Ruoying, additional, Tay, Wan-Ting, additional, Zheng, Yingfeng, additional, Chew, Merwyn, additional, Burdon, Kathryn P., additional, Craig, Jamie E., additional, Iyengar, Sudha K., additional, Igo, Robert P., additional, Lass, Jonathan H., additional, Chew, Emily Y., additional, Haller, Toomas, additional, Mihailov, Evelin, additional, Metspalu, Andres, additional, Wedenoja, Juho, additional, Simpson, Claire L., additional, Wojciechowski, Robert, additional, Höhn, René, additional, Mirshahi, Alireza, additional, Zeller, Tanja, additional, Pfeiffer, Norbert, additional, Lackner, Karl J., additional, Bettecken, Thomas, additional, Meitinger, Thomas, additional, Oexle, Konrad, additional, Pirastu, Mario, additional, Portas, Laura, additional, Nag, Abhishek, additional, Williams, Katie M., additional, Yonova-Doing, Ekaterina, additional, Klein, Ronald, additional, Klein, Barbara E., additional, Hosseini, S. Mohsen, additional, Paterson, Andrew D., additional, Makela, Kari-Matti, additional, Lehtimaki, Terho, additional, Kahonen, Mika, additional, Raitakari, Olli, additional, Yoshimura, Nagahisa, additional, Matsuda, Fumihiko, additional, Chen, Li Jia, additional, Pang, Chi Pui, additional, Yip, Shea Ping, additional, Yap, Maurice K.H., additional, Meguro, Akira, additional, Mizuki, Nobuhisa, additional, Inoko, Hidetoshi, additional, Foster, Paul J., additional, Zhao, Jing Hua, additional, Vithana, Eranga, additional, Tai, E-Shyong, additional, Fan, Qiao, additional, Xu, Liang, additional, Campbell, Harry, additional, Fleck, Brian, additional, Rudan, Igor, additional, Aung, Tin, additional, Hofman, Albert, additional, Uitterlinden, André G., additional, Bencic, Goran, additional, Khor, Chiea-Chuen, additional, Forward, Hannah, additional, Pärssinen, Olavi, additional, Mitchell, Paul, additional, Rivadeneira, Fernando, additional, Hewitt, Alex W., additional, Williams, Cathy, additional, Oostra, Ben A., additional, Teo, Yik-Ying, additional, Hammond, Christopher J., additional, Stambolian, Dwight, additional, Mackey, David A., additional, Klaver, Caroline C.W., additional, Wong, Tien-Yin, additional, Saw, Seang-Mei, additional, Baird, Paul N., additional, Reinhart, William, additional, Belin, Michael W., additional, Schultze, Robert L., additional, Morason, Todd, additional, Sugar, Alan, additional, Mian, Shahzad, additional, Soong, Hunson Kaz, additional, Colby, Kathryn, additional, Jurkunas, Ula, additional, Yee, Richard, additional, Vital, Mark, additional, Alfonso, Eduardo, additional, Karp, Carol, additional, Lee, Yunhee, additional, Yoo, Sonia, additional, Hammersmith, Kristin, additional, Cohen, Elisabeth, additional, Laibson, Peter, additional, Rapuano, Christopher, additional, Ayres, Brandon, additional, Croasdale, Christopher, additional, Caudill, James, additional, Patel, Sanjay, additional, Baratz, Keith, additional, Bourne, William, additional, Maguire, Leo, additional, Sugar, Joel, additional, Tu, Elmer, additional, Djalilian, Ali, additional, Mootha, Vinod, additional, McCulley, James, additional, Bowman, Wayne, additional, Cavanaugh, H. Dwight, additional, Verity, Steven, additional, Verdier, David, additional, Renucci, Ann, additional, Oliva, Matt, additional, Rotkis, Walter, additional, Hardten, David R., additional, Fahmy, Ahmad, additional, Brown, Marlene, additional, Reeves, Sherman, additional, Davis, Elizabeth A., additional, Lindstrom, Richard, additional, Hauswirth, Scott, additional, Hamilton, Stephen, additional, Lee, W. Barry, additional, Price, Francis, additional, Price, Marianne, additional, Kelly, Kathleen, additional, Peters, Faye, additional, Shaughnessy, Michael, additional, Steinemann, Thomas, additional, Dupps, B.J., additional, Meisler, David M., additional, Mifflin, Mark, additional, Olson, Randal, additional, Aldave, Anthony, additional, Holland, Gary, additional, Mondino, Bartly J., additional, Rosenwasser, George, additional, Gorovoy, Mark, additional, Dunn, Steven P., additional, Heidemann, David G., additional, Terry, Mark, additional, Shamie, Neda, additional, Rosenfeld, Steven I., additional, Suedekum, Brandon, additional, Hwang, David, additional, Stone, Donald, additional, Chodosh, James, additional, Galentine, Paul G., additional, Bardenstein, David, additional, Goddard, Katrina, additional, Chin, Hemin, additional, Mannis, Mark, additional, Varma, Rohit, additional, and Borecki, Ingrid, additional

Published
2013
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22. Macular Degeneration in a Patient with Aceruloplasminemia, a Disease Associated with Retinal Iron Overload

Author

Dunaief, Joshua L., Richa, Chimene, Franks, Edward P., Schultze, Robert L., Aleman, Tomas S., Schenck, John F., Zimmerman, Earl A., and Brooks, David G.

Subjects
*RETINOIDS, *EPITHELIUM, *PHYSIOLOGICAL control systems, *EYE examination
Abstract

Purpose: To provide the first ophthalmic case report of a Caucasian patient with the rare autosomal recessive disease aceruloplasminemia, which results in iron overload in the retina, brain, and pancreas. Design: Single observational case report. Methods: Perls’ staining of a conjunctival biopsy was used to detect elevated iron levels in the conjunctival epithelium. Fundus photography, fluorescein angiography, and electroretinography were used to document retinal appearance and function. Results: Unlike a report of a Japanese patient with aceruloplasminemia, who had midperipheral retinal pigment epithelium (RPE) cell atrophy and yellowish discoloration of the fundus, our Caucasian patient had a maculopathy. Beginning at age 47, he had development and progression of multiple subretinal yellowish-white lesions and RPE cell atrophy. To confirm tissue iron overload in our patient, we took the novel approach of a conjunctival biopsy, which showed Perls’ Prussian blue-positive epithelial cells. Conclusions: Given our recent finding of elevated iron levels in the RPE of patients with age-related macular degeneration (AMD), it is interesting that retinal iron overload in aceruloplasminemia is associated with a maculopathy that clinically resembles AMD. This finding supports the hypothesis that retinal iron homeostasis is essential for normal retinal function. Disruption of iron homeostasis could contribute to the pathogenesis of AMD. [Copyright &y& Elsevier]

Published
2005
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23. Donor age and corneal endothelial cell loss 5 years after successful corneal transplantation. Specular microscopy ancillary study results.

Author

Lass JH, Gal RL, Dontchev M, Beck RW, Kollman C, Dunn SP, Heck E, Holland EJ, Mannis MJ, Montoya MM, Schultze RL, Stulting RD, Sugar A, Sugar J, Tennant B, and Verdier DD

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cell Count, Child, Corneal Edema etiology, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Period, Prospective Studies, Pseudophakia complications, Age Factors, Corneal Edema surgery, Corneal Transplantation, Endothelium, Corneal pathology, Fuchs' Endothelial Dystrophy surgery, Tissue Donors
Abstract

Objective: To determine whether endothelial cell loss 5 years after successful corneal transplantation is related to the age of the donor., Design: Multicenter, prospective, double-masked clinical trial., Participants: Three hundred forty-seven subjects participating in the Cornea Donor Study who had not experienced graft failure 5 years after corneal transplantation for a moderate-risk condition (principally Fuchs' dystrophy or pseudophakic corneal edema)., Testing: Specular microscopic images of donor corneas obtained before surgery and postoperatively at 6 months, 12 months, and then annually through 5 years were submitted to a central reading center to measure endothelial cell density (ECD)., Main Outcome Measure: Endothelial cell density at 5 years., Results: At 5 years, there was a substantial decrease in ECD from baseline for all donor ages. Subjects who received a cornea from a donor 12 to 65 years old experienced a median cell loss of 69% in the study eye, resulting in a 5-year median ECD of 824 cells/mm(2) (interquartile range, 613-1342), whereas subjects who received a cornea from a donor 66 to 75 years old experienced a cell loss of 75%, resulting in a median 5-year ECD of 654 cells/mm(2) (interquartile range, 538-986) (P [adjusted for baseline ECD] = 0.04). Statistically, there was a weak negative association between ECD and donor age analyzed as a continuous variable (r [adjusted for baseline ECD] = -0.19; 95% confidence interval, -0.29 to -0.08)., Conclusions: Endothelial cell loss is substantial in the 5 years after corneal transplantation. There is a slight association between cell loss and donor age. This finding emphasizes the importance of longer-term follow-up of this cohort to determine if this relationship affects graft survival.

Published
2008
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24. The effect of donor age on corneal transplantation outcome results of the cornea donor study.

Author

gal RL, Dontchev M, Beck RW, Mannis MJ, Holland EJ, Kollman C, Dunn SP, Heck EL, Lass JH, Montoya MM, Schultze RL, Stulting RD, Sugar A, Sugar J, Tennant B, and Verdier DD

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Corneal Edema etiology, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pseudophakia complications, Treatment Outcome, Age Factors, Corneal Edema surgery, Corneal Transplantation, Fuchs' Endothelial Dystrophy surgery, Graft Survival, Tissue Donors
Abstract

Objective: To determine whether graft survival over a 5-year follow-up period using corneal tissue from donors older than 65 is similar to graft survival using corneas from younger donors., Design: Multicenter prospective, double-masked, controlled clinical trial., Participants: One thousand ninety subjects undergoing corneal transplantation for a moderate-risk condition (principally Fuchs' dystrophy or pseudophakic corneal edema); 11 subjects with ineligible diagnoses were not included., Methods: Forty-three participating eye banks provided corneas from donors in the age range of 12 to 75 with endothelial cell densities of 2300 to 3300 cells/mm(2), using a random approach without respect to recipient factors. The 105 participating surgeons at 80 sites were masked to information about the donor cornea including donor age. Surgery and postoperative care were performed according to the surgeons' usual routines. Subjects were observed for 5 years., Main Outcome Measures: Graft failure, defined as a regraft or a cloudy cornea that was sufficiently opaque as to compromise vision for a minimum of 3 consecutive months., Results: The 5-year cumulative probability of graft survival was 86% in both the <66.0 donor age group and the >/=66.0 donor age group (difference = 0%, upper limit of 1-sided 95% confidence interval = 4%). In a statistical model with donor age as a continuous variable, there was no significant relationship between donor age and outcome (P = 0.11). Three graft failures were due to primary donor failure, 8 to uncorrectable refractive error, 48 to graft rejection, 46 to endothelial decompensation (23 of which had a prior, resolved episode of probable or definite graft rejection), and 30 to other causes. Distributions of the causes of graft failure did not differ between donor age groups., Conclusions: Five-year graft survivals for cornea transplants at moderate risk for failure are similar using corneas from donors >/= 66.0 years and donors < 66.0. Surgeons and patients now have evidence that corneas comparable in quality to those used in this study from donors through age 75 are suitable for transplantation.

Published
2008
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