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273 results on '"Schultz M.J."'

2. High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19

Author

Ahuja, S., van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Aydeniz, E., Bailey, M., van den Berg, A.E., van de Berg, P., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bevers, M., Bindels, A.J.G.H., Breel, J.S., de Bruin, S., Bruna, C.L., de Boer, M., Boer, D.P., den Boer, S., Boers, L.S., Bogerd, M.B., Bos, L.D., Bosman, B., Botta, M., de Bie, A.J.R., Baur, O.L., Buiteman-Kruizinga, L.A., Coene, W., Cremer, O.L., Daenen, K., Delmte, M., Determann, R.M., Dieperink, W., Di Leo, V., van Dijk, J., Dongelmans, D.A., Dormans, T., Endeman, H., Elting, L.M., Esmeijer, A.A., Filippini, D., Flim, J.M., Franke, H.S., Galek-aldridge, M.S., de Abreu, M.G. Gama, Girbes, A.R., Go, D.M., Goossen, R.L., de Graaff, M.J., Hagens, L.A., Hansen, H.J., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, I., van der Horst, R., Huijben, J.A., Ie, E.L.K., van Ingen, L.E., Ivanov, D.P., Juffermans, N.P., Kranen, H.T., Kho, E., de Klerk, E.S., Koek, N., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., Kuipers, L.J., Koornstra, E., Lokhorst, A., de Lange, D.W., Martin-Loeches, I., van Meenen, D.M.P., Mazzinari, G., Moeniralam, H., van Mourik, N., Myatra, S.N., Nijbroek, S.G., van Oosten, P., Offermans, M., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Peršec, J., Peters, V.J.T., Pillay, J.J., Pisani, L., Pisters, T., Prins, A., Purmer, I.M., Rettig, T.C.D., Rezaee, A.S., Roca, O., Roozeman, J., Rozendaal, J., Rosenberg, N.M., Schavemaker, R., Sciascera, A., Schuijt, M.T.U., Schultz, M.J., Neto, A.S. Serpa, Shrestha, G.S., van Silfhout, B., Sjoding, M., Sleeswijk, M.E., van Smaalen, K.M., Smit, M.R., Spronk, P.E., Šribar, A., Strang, A.C., Stilma, W., Swart, P., Tuinman, P.R., Tsonas, A.M., den Uil, C.A., Valk, C.M.A., Veen-Schra, F.L., Vlaar, A.P.J., Veldhuis, L.I., van der Ven, W.H., van der Ven, F.L.I.M., van Velzen, P., Verboom, M., Verhoef, E.J., Vermeulen, T.D., van Vliet, P., van Vliet, R., Voorham, J.S., van der Voort, P.H.J., van Welie, L., Weller, D., Wentink, A.R., Wesselink, H.J.F.T., van der Wier-Lubbers, H., van Wijk, B., van Willigen, H., van der Woude, M.C.E., Weiner, J.J., Winters, T., Wong, W.Y., Yaali, N., Zandvliet, J.M., van Zanten, A.R.H., van Zijl, T.Z.I., Zonneveld, S.A., Goossen, Robin L., van Vliet, Relin, Bos, Lieuwe D.J., Buiteman-Kruizinga, Laura A., Hollman, Markus W., Myatra, Sheila N., Neto, Ary Serpa, Spronk, Peter E., van der Woude, Meta C.E., van Meenen, David M.P., Paulus, Frederique, and Schultz, Marcus J.

Published
2024
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4. Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection

Author

van Agtmael, M.A., Algera, A.G., Appelman, B., van Baarle, F.E.H.P., Beudel, M., Bogaard, H.J., Bomers, M., Bonta, P.I., Bos, L.D.J., Botta, M., de Brabander, J., de Bree, G.J., de Bruin, S., Bugiani, M., Bulle, E.B., Chouchane, O., Cloherty, A.P.M., Buis, D., de Rotte, M.C.F.J., Dijkstra, M., Dongelmans, D.A., Dujardin, R.W.G., Elbers, P.E., Fleuren, L.M., Geerlings, S.E., Geijtenbeek, T.B.H., Girbes, A.R.J., Goorhuis, A., Grobusch, M.P., Hagens, L.A., Hamann, J., Harris, V.C., Hemke, R., Hermans, S.M., Heunks, L.M.A., Hollmann, M.W., Horn, J., Hovius, J.W., de Jong, M.D., Koing, R., Lim, E.H.T., van Mourik, N., Nellen, J.F., Nossent, E.J., Paulus, F., Peters, E., Piña-Fuentes, D., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, S.J., Reijnders, T.D.Y., Schinkel, M., Schrauwen, F.A.P., Schultz, M.J., Schuurman, A.R., Schuurmans, J., Sigaloff, K., Slim, M.A., Smeele, P., Smit, M.R., Stijnis, C., Stilma, W., Teunissen, C.E., Thoral, P., Tsonas, A.M., Tuinman, P.R., van der Valk, M., Veelo, D.P., Volleman, C., de Vries, H., van Vught, L.A., van Vugt, M., Wouters, D., Zwinderman, A.H., Brouwer, M.C., Wiersinga, W.J., Vlaar, A.P.J., van de Beek, D., Guo, Lihui, Appelman, Brent, Mooij-Kalverda, Kirsten, Houtkooper, Riekelt H., van Weeghel, Michel, Vaz, Frédéric M., Dijkhuis, Annemiek, Dekker, Tamara, Smids, Barbara S., Duitman, Jan Willem, Bugiani, Marianna, Brinkman, Paul, Sikkens, Jonne J., Lavell, H.A. Ayesha, Wüst, Rob C.I., van Vugt, Michèle, and Lutter, René

Published
2023
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7. Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

Author

Algera, A.G., Boers, L.S., Bos, L.D.J., Botta, M., Dongelmans, D.A., Hollmann, M.W., Horn, J., Paulus, F., Pillay, J., Schultz, M.J., Neto, A. Serpa, Tsonas, A.M., Vlaar, A.P.J., Ahuja, S., van Akkeren, J.P., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Bogerd, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O.L., Determann, R.M., Dieperink, W., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hoogendoorn, M.E., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Pennartz, C.J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Roozeman, Jan-Paul, Mazzinari, Guido, Serpa Neto, Ary, Hollmann, Markus W., Paulus, Frederique, Schultz, Marcus J., and Pisani, Luigi

Published
2022
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10. Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

Author

van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman-van Gemert, A.W.M.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., Martin-Loeches, I., Mazzinari, G., van Meenen, D.M.P., Morales-Quinteros, L., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Serpa Neto, A., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., Vlaar, A.P.J., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Bos, Lieuwe D J, Sjoding, Michael, Sinha, Pratik, Bhavani, Sivasubramanium V, Lyons, Patrick G, Bewley, Alice F, Botta, Michela, Tsonas, Anissa M, Serpa Neto, Ary, Schultz, Marcus J, Dickson, Robert P, and Paulus, Frederique

Published
2021
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11. Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study

Author

van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Aldridge, M.S. Galek, de Graaff, M.J., Hagens, L.A., Haringman, J.J., Heijnen, N.F.L., Hiel, S., van der Heide, S.T., van der Heiden, P.L.J., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman, A.W.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Martin-Loeches, I., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Neto, A. Serpa, Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen, F.L., Vlaar, A.P.J., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P., van der Wier, H.H., van Welie, L., Wesselink, H.J.F.T., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Schuijt, Michiel T.U., Martin-Loeches, Ignacio, Schultz, Marcus J., Paulus, Frederique, and Neto, Ary Serpa

Published
2021
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12. Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients

Author

van Agtmael, M., Algera, A.G., van Baarle, F., Bax, D., Beudel, M., Bogaard, H.J., Bomers, M., Bos, L., Botta, M., de Brabander, J., Brouwer, M.C., de Bruin, S., Bugiani, M., Bulle, E., Chouchane, O., Cloherty, A., Elbers, P., Fleuren, L., Geerlings, S., Geerts, B., Geijtenbeek, T., Girbes, A., Goorhuis, A., Grobusch, M.P., Hafkamp, F., Hagens, L., Hamann, J., Harris, V., Hemke, R., Hermans, S.M., Heunks, L., Hollmann, M.W., Horn, J., Hovius, J.W., Koning, R., van Mourik, N., Nellen, J., Paulus, F., Peters, E., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, J., Reijnders, T., Schinkel, M., Schultz, M.J., Schuurman, A., Sigaloff, K., Smit, M., Stijnis, C.S., Stilma, W., Thoral, P., Tsonas, A., van der Valk, M., Veelo, D., Vlaar, A.P.J., de Vries, H., Wiersinga, W.J., Wouters, D., Zwinderman, A.H., van de Beek, D., Zonneveld, Rens, Jurriaans, Suzanne, van Gool, Tom, Hofstra, Jorrit J., Hekker, Thecla A.M., Defoer, Pien, Broekhuizen-van Haaften, Patricia E., Wentink-Bonnema, Ellen M., Boonkamp, Lynn, Teunissen, Charlotte E., Heijboer, Annemieke C., Martens, Frans, de Bree, Godelieve, van Vugt, Michele, van Houdt, Robin, Schinkel, Janke, and de Jong, Menno D.

Published
2021
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13. Ventilation and outcomes following robotic-assisted abdominal surgery: an international, multicentre observational study

Author

Queiroz, Veronica N.F., da Costa, Luis Guilherme V., Takaoka, Flavio, Pelosi, Paolo, de Abreu, Marcelo Gama, Schultz, Marcus J., Serpa Neto, Ary, Barbosa, R.P., Canet, J., Cata, J.P., Cesar, D.S., Chaves, R.C.F., D’Orto, U.C., Da Costa, L.G.V., De Baerdemaeker, L., Galdi, J.R., Gama de Abreu, M., Gottumukkala, V., Hemmes, S.N.T., Hollmann, M.W., Kalmar, A.F., Mariano, R., Matot, I., Mazzinari, G., Mills, G.H., Pelosi, P., Posso, I.P., Queiroz, V.N.F., Schultz, M.J., Serpa Neto, A., Sprung, J., Takaoka, F., Teruya, A., Vidal Melo, M.F., Agarwala, Aalok V., Akeroyd, Louise, Andorlini, Francesco, Anicetti, Lisa, Antonelli, Massimo, Arantes, Bruno S., Ariño Irujo, Jose J., Artsi, Hanna, Babian, Renata, Barbosa, Rogerio P., Barker, Doug, Basagni, Diletta, Basso, Nicola, Beltran, Joan, Bocciero, Vittorio, Bonatti, Giulia, Boriati, Ernesto, Bravo, Mauro, Brazzi, Luca, Brearton, Chris, Brennan, Andrew, Bulinski, Adam M., Cafagna, Sara, Cardoni, Andrea, Castelló Mora, Paula, Cata, Juan P., Cesar, Daniel S., Chaves, Renato CF., Chen, Lee-Lynn, Chukkambotla, Srikanth, Ciccozzi, Alessandra, Cilia, Danae, Cope, Sean, D’Orto, Ulisses C., Da Costa, Luis Guilherme V., Dalton, Claire, Davi, Alessandra, De Bonis, Marina del Barrio, De Gaudio, Angelo Raffaele, De Luca, Lucilla, Delgado, Carlos C., Deljou, Atousa, Di Ruscio, Cecilia, Droger, Sijgje M., Duberley, Stephen, Eidelman, Leonid A., Evans, Alison, Fabiani, Constanza, Fasciano, Umberto, Firth-Gieben, Jennifer, Fitchett, Jillian, Fundarò, Angela, Galdi, Jose Roberto, Gallo, Verdiana, Gavagni, Mattia, Gottumukkala, Vijaya, Graham, Chris, Granell Gil, Manuel, Gratarola, Angelo, Grillandini, Chiara, Groeben, Harald-Thomas, Ismail, Nesrine, Jacob, Reni, Jones, Chris, Jones, Rebecca, Kalmar, Alain F., Kapoor, Ritoo, Kelliher, Leigh, Köhne, Wiebke, Koopman, Joseph SHA., Lanka, Prasad, Lee, Jae-Woo, Liban, Bernard, Livi, Francesca, Mariano, Renato, Martinez Plumed, Ruth, Matot, Idit, Mazzella, Marta, McClure, Stewart, McMonagle, Martina, Mills, Gary H., Mirabella, Lucia, Monsalve, Concepción, Moon, Angela, Morchio, Laura, Morris, Frances, Motroni, Lorenzo, Mura, Benedetta, Nerini, Alessandro, Noumedem Sonna, Elodia C., Oakes, Neil, Orlandi, Marina, Paladini, Antonella, Patil, Anita, Patil, Vishal, Patrone, Valentina, Pinder, Angela, Piroli, Alba, Posso, Irimar P., Queiroz, Veronica NF., Rabbu, Yosef S., Rabenalt, Robert, Romagnoli, Stefano, Ronen, Ariel, Rothman, Felipe, Rusagara, Patrick, Russo, Andrea, Sabov, Moldovan, Saitta, Thomas, Shah, Nirav, Smith, Neil, Sollazzi, Liliana, Sprung, Juraj, Stewart, Emma, Stones, Elizabeth, Storton, Kim, Tena, Beatriz, Terreni, Eleonora, Teruya, Alexandre, Travaglia, Chiara, Treschan, Tanja A., Vanoverschelde, Henk, Venkatesh, Harish, Vidal Melo, Marcos F., Villa, Gianluca, Vossen, Robbert, Webber, Stephen, Weingarten, Toby N., Willcocks, Matt, Winslow, Luke, and Woods, Lindsey

Published
2021
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15. Re–evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery – Protocol and statistical analysis plan for an individual patient data meta–analysis of PROVHILO, iPROVE and PROBESE

Author

Campos, N.S., Bluth, T., Hemmes, S.N.T., Librero, J., Pozo, N., Ferrando, C., Ball, L., Mazzinari, G., Pelosi, P., Gama de Abreu, M., Schultz, M.J., and Serpa Neto, A.

Published
2020
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16. Reevaluación de los efectos de PEEP alta con maniobras de reclutamiento vs. PEEP baja sin maniobras de reclutamiento durante la anestesia general para cirugía: protocolo y plan de análisis estadístico para un metaanálisis de los datos de pacientes individuales de PROVHILO, iPROVE y PROBESE

Author

Campos, N.S., Bluth, T., Hemmes, S.N.T., Librero, J., Pozo, N., Ferrando, C., Ball, L., Mazzinari, G., Pelosi, P., Gama de Abreu, M., Schultz, M.J., and Neto, A.S.

Published
2020
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17. Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

Author

Kroell, W., Metzler, H., Struber, G., Wegscheider, T., Gombotz, H., Hiesmayr, M., Schmid, W., Urbanek, B., Kahn, D., Momeni, M., Pospiech, A., Lois, F., Forget, P., Grosu, I., Poelaert, J., Mossevelde, V., van Malderen, M.C., Dylst, D., Melkebeek, J.V., Beran, M., Hert, S.D., Baerdemaeker, L.D., Heyse, B., Limmen, J.V., Wyffels, P., Jacobs, T., Roels, N., Bruyne, A.D., Velde, S.V.D., Marina, J.Z., Dejana, D.O., Pernar, S., Zunic, J., Miskovic, P., Zilic, A., Kvolik, S., Ivic, D., Darija, A.V., Skiljic, S., Vinkovic, H., Oputric, I., Juricic, K., Frkovic, V., Kopic, J., Mirkovic, I., Saric, J.P., Erceg, G., Dvorscak, M.B., Branka, M.S., Pavicic, A.M., Goranovic, T., Maldini, B., Radocaj, T., Gavranovic, Z., Inga, M.B., Sehovic, M., Stourac, P., Harazim, H., Smekalova, O., Kosinova, M., Kolacek, T., Hudacek, K., Drab, M., Brujevic, J., Vitkova, K., Jirmanova, K., Volfova, I., Dzurnakova, P., Liskova, K., Dudas, R., Filipsky, R., Kafrawy, S.E., Abdelwahab, H.H., Metwally, T., Ahmed, A.R., Ahmed Mostafa, E.S., Hasan, W.F., Ahmed, A.G., Yassin, H., Magdy, M., Abdelhady, M., Mahran, M., Herodes, E., Kivik, P., Oganjan, J., Aun, A., Sormus, A., Sarapuu, K., Mall, M., Karjagin, J., Futier, E., Petit, A., Gerard, A., Marret, E., Solier, M., Jaber, S., Prades, A., Krassler, J., Merzky, S., Abreu, M.G.D., Uhlig, C., Kiss, T., Bundy, A., Bluth, T., Gueldner, A., Spieth, P., Scharffenberg, M., Thiem, D.T., Koch, T., Treschan, T., Schaefer, M., Bastin, B., Geib, J., Weiss, M., Kienbaum, P., Pannen, B., Gottschalk, A., Konrad, M., Westerheide, D., Schwerdtfeger, B., Wrigge, H., Simon, P., Reske, A., Nestler, C., Valsamidis, D., Stroumpoulis, K., Antholopoulos, G., Andreou, A., Karapanos, D., Theodoraki, K., Gkiokas, G., Tasoulis, M.K., Sidiropoulou, T., Zafeiropoulou, F., Florou, P., Pandazi, A., Tsaousi, G., Nouris, C., Pourzitaki, C., Bystritski, D., Pizov, R., Eden, A., Pesce, C.V., Campanile, A., Marrella, A., Grasso, S., Michele, M.D., Bona, F., Giacoletto, G., Sardo, E., Sottosanti, L.G.V., Solca, M., Volta, C.A., Spadaro, S., Verri, M., Ragazzi, R., Zoppellari, R., Cinnella, G., Raimondo, P., Bella, D.L., Mirabella, L., D'antini, D., Pelosi, P., Molin, A., Brunetti, I., Gratarola, A., Pellerano, G., Sileo, R., Pezzatto, S., Montagnani, L., Pasin, L., Landoni, G., Zangrillo, A., Beretta, L., Parma, A.L.D., Tarzia, V., Dossi, R., Sassone, M.E., Sances, D., Tredici, S., Spano, G., Castellani, G., Delunas, L., Peradze, S., Venturino, M., Arpino, I., Sher, S., Tommasino, C., Rapido, F., Morelli, P., Vargas, M., Servillo, G., Cortegiani, A., Raineri, S.M., Montalto, F., Russotto, V., Giarratano, A., Baciarello, M., Generali, M., Cerati, G., Leykin, Y., Bressan, F., Bartolini, V., Zamidei, L., Brazzi, L., Liperi, C., Sales, G., Pistidda, L., Severgnini, P., Brugnoni, E., Musella, G., Bacuzzi, A., Muhardri, D., Agreta, G.G., Sada, F., Bytyqi, A., Karbonskiene, A., Aukstakalniene, R., Teberaite, Z., Salciute, E., Tikuisis, R., Miliauskas, P., Jurate, S., Kontrimaviciute, E., Tomkute, G., Xuereb, J., Bezzina, M., Borg, F. Joseph, Hemmes, S., Schultz, M., Hollmann, M., Wiersma, I., Binnekade, J., Bos, L., Boer, C., Duvekot, A., Veld, B.I ‘t, Werger, A., Dennesen, P., Severijns, C., Jong, J.D., Hering, J., Beek, R.V., Ivars, S., Jammer, I.B., Breidablik, A., Hodt, K.S., Fjellanger, F., Avalos, M.V., Jannicke, M.O., Andersson, E., Amir, S.K., Molina, R., Wutai, S., Morais, E., Tareco, G., Ferreira, D., Amaral, J., Castro, M.D.L.G., Cadilha, S., Appleton, S., Parente, S., Correia, M., Martins, D., Monteirosa, A., Ricardo, A., Rodrigues, S., Horhota, L., Grintescu, I.M., Mirea, L., Grintescu, I.C., Corneci, D., Negoita, S., Dutu, M., Popescu Garotescu, I., Filipescu, D., Prodan, A.B., Droc, G., Fota, R., Popescu, M., Tomescu, D., Petcu, A.M., Tudoroiu, M.I., Moise, A., Guran, C.T., Gherghina, I., Costea, D., Cindea, I., Copotoiu, S.M., Copotoiu, R., Barsan, V., Tolcser, Z., Riciu, M., Moldovan, S.G., Veres, M., Gritsan, A., Kapkan, T., Gritsan, G., Korolkov, O., Kulikov, A., Lubnin, A., Ovezov, A., Prokoshev, P., Lugovoy, A., Anipchenko, N., Babayants, A., Komissarova, I., Zalina, K., Likhvantsev, V., Fedorov, S., Lazukic, A., Pejakovic, J., Mihajlovic, D., Kusnierikova, Z., Zelinkova, M., Bruncakova, K., Polakovicova, L., Sobona, V., Barbka, N.S., Ana, P.G., Jovanov, M., Strazisar, B., Jasmina, M.B., Vesna, N.J., Voje, M., Grynyuk, A., Kostadinov, I., Alenka, S.V., Moral, V., Unzueta, M.C., Puigbo, C., Fava, J., Canet, J., Moret, E., Nunez, M.R., Sendra, M., Brunelli, A., Rodenas, F., Monedero, P., Hidalgo, F., Yepes, M.J., Martinez-Simon, A., Abajo, A., Lisi, A., Perez, G., Martinez, R., Granell, M., Vivo, J.T., Ruiz, C.S., Andrés Ibañez, J.A.D., Pastor, E., Soro, M., Ferrando, C., Defez, M., Cesar Aldecoa, A.S., Perez, R., Rico, J., Jawad, M., Saeed, Y., Gillberg, L., Bengisun, Z.K., Kazbek, B.K., Coskunfirat, N., Boztug, N., Sanli, S., Yilmaz, M., Hadimioglu, N., Senturk, N.M., Camci, E., Kucukgoncu, S., Sungur, Z., Sivrikoz, N., Ozgen, S.U., Toraman, F., Selvi, O., Senturk, O., Yildiz, M., Kuvaki, B., Gunenc, F., Kucukguclu, S., Ozbilgin, S., Maral, J., Canli, S., Arun, O., Saltali, A., Aydogan, E., Akgun, F.N., Sanlikarip, C., Karaman, F.M., Mazur, A., Vorotyntsev, S., Rousseau, G., Barrett, C., Stancombe, L., Shelley, B., Scholes, H., Limb, J., Rafi, A., Wayman, L., Deane, J., Rogerson, D., Williams, J., Yates, S., Rogers, E., Pulletz, M., Moreton, S., Jones, S., Venkatesh, S., Burton, M., Brown, L., Goodall, C., Rucklidge, M., Fuller, D., Nadolski, M., Kusre, S., Lundberg, M., Everett, L., Nutt, H., Zuleika, M., Carvalho, P., Clements, D., Ben, C.B., Watt, P., Raymode, P., Pearse, R., Mohr, O., Raj, A., Creary, T., Chishti, A., Bell, A., Higham, C., Cain, A., Gibb, S., Mowat, S., Franklin, D., West, C., Minto, G., Boyd, N., Mills, G., Calton, E., Walker, R., Mackenzie, F., Ellison, B., Roberts, H., Chikungwa, M., Jackson, C., Donovan, A., Foot, J., Homan, E., Montgomery, J., Portch, D., Mercer, P., Palmer, J., Paddle, J., Fouracres, A., Datson, A., Andrew, A., Welch, L., Rose, A., Varma, S., Simeson, K., Rambhatla, M., Susarla, J., Marri, S., Kodaganallur, K., Das, A., Algarsamy, S., Colley, J., Davies, S., Szewczyk, M., Smith, T., Ana, F.B., Luzier, E., Almagro, A., Melo, M.V., Fernando, L., Sulemanji, D., Sprung, J., Weingarten, T., Kor, D., Scavonetto, F., Tze, Y., Gregoretti, C., Neto, A.S., Hemmes, S.N.T., Ball, L., Hollmann, M.W., Mills, G.H., Melo, M.F.V., Putensen, C., Gama de Abreu, M., and Schultz, M.J.

Published
2019
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19. A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications

Author

Myles, P., Gan, T.J., Kurz, A., Peyton, P., Sessler, D., Tramèr, M., Cyna, A., De Oliveira, G.S., Jr., Wu, C., Jensen, M., Kehlet, H., Botti, M., Boney, O., Haller, G., Grocott, M., Cook, T., Fleisher, L., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, Lis, Scott, D., Silbert, B., van Dijk, D., Kalkman, C., Chan, M., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Wijeysundera, D., Landoni, G., Leslie, K., Biccard, B., Howell, S., Nagele, P., Richards, T., Lamy, A., Gabreu, M., Klein, A., Corcoran, T., Jamie Cooper, D., Dieleman, S., Diouf, E., McIlroy, D., Bellomo, R., Shaw, A., Prowle, J., Karkouti, K., Billings, J., Mazer, D., Jayarajah, M., Murphy, M., Bartoszko, J., Sneyd, R., Morris, S., George, R., Moonesinghe, R., Shulman, M., Lane-Fall, M., Nilsson, U., Stevenson, N., van Klei, W., Cabrini, L., Miller, T., Pace, N., Jackson, S., Buggy, D., Short, T., Riedel, B., Gottumukkala, V., Alkhaffaf, B., Johnson, M., Abbott, T.E.F., Fowler, A.J., Pelosi, P., Gama de Abreu, M., Møller, A.M., Canet, J., Creagh-Brown, B., Mythen, M., Gin, T., Lalu, M.M., Futier, E., Grocott, M.P., Schultz, M.J., and Pearse, R.M.

Published
2018
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22. Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection

Author

Guo, Lihui, primary, Appelman, Brent, additional, Mooij-Kalverda, Kirsten, additional, Houtkooper, Riekelt H., additional, van Weeghel, Michel, additional, Vaz, Frédéric M., additional, Dijkhuis, Annemiek, additional, Dekker, Tamara, additional, Smids, Barbara S., additional, Duitman, Jan Willem, additional, Bugiani, Marianna, additional, Brinkman, Paul, additional, Sikkens, Jonne J., additional, Lavell, H.A. Ayesha, additional, Wüst, Rob C.I., additional, van Vugt, Michèle, additional, Lutter, René, additional, van Agtmael, M.A., additional, Algera, A.G., additional, Appelman, B., additional, van Baarle, F.E.H.P., additional, Beudel, M., additional, Bogaard, H.J., additional, Bomers, M., additional, Bonta, P.I., additional, Bos, L.D.J., additional, Botta, M., additional, de Brabander, J., additional, de Bree, G.J., additional, de Bruin, S., additional, Bugiani, M., additional, Bulle, E.B., additional, Chouchane, O., additional, Cloherty, A.P.M., additional, Buis, D., additional, de Rotte, M.C.F.J., additional, Dijkstra, M., additional, Dongelmans, D.A., additional, Dujardin, R.W.G., additional, Elbers, P.E., additional, Fleuren, L.M., additional, Geerlings, S.E., additional, Geijtenbeek, T.B.H., additional, Girbes, A.R.J., additional, Goorhuis, A., additional, Grobusch, M.P., additional, Hagens, L.A., additional, Hamann, J., additional, Harris, V.C., additional, Hemke, R., additional, Hermans, S.M., additional, Heunks, L.M.A., additional, Hollmann, M.W., additional, Horn, J., additional, Hovius, J.W., additional, de Jong, M.D., additional, Koing, R., additional, Lim, E.H.T., additional, van Mourik, N., additional, Nellen, J.F., additional, Nossent, E.J., additional, Paulus, F., additional, Peters, E., additional, Piña-Fuentes, D., additional, van der Poll, T., additional, Preckel, B., additional, Prins, J.M., additional, Raasveld, S.J., additional, Reijnders, T.D.Y., additional, Schinkel, M., additional, Schrauwen, F.A.P., additional, Schultz, M.J., additional, Schuurman, A.R., additional, Schuurmans, J., additional, Sigaloff, K., additional, Slim, M.A., additional, Smeele, P., additional, Smit, M.R., additional, Stijnis, C., additional, Stilma, W., additional, Teunissen, C.E., additional, Thoral, P., additional, Tsonas, A.M., additional, Tuinman, P.R., additional, van der Valk, M., additional, Veelo, D.P., additional, Volleman, C., additional, de Vries, H., additional, van Vught, L.A., additional, van Vugt, M., additional, Wouters, D., additional, Zwinderman, A.H., additional, Brouwer, M.C., additional, Wiersinga, W.J., additional, Vlaar, A.P.J., additional, and van de Beek, D., additional

Published
2023
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24. Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients (CONFIDENCE): protocol for a multicentre randomised controlled trial.

Author

Blok, S.G., Mousa, A., Brouwer, M.G., Grooth, H.J. de, Neto, A.S., Blans, M.J., Boer, S de, Dormans, T., Endeman, H., Roeleveld, T., Scholten, Harm, Slobbe-Bijlsma, E.R. van, Scholten, E., Touw, H.R.W., Ven, F.S.L.I.M. van der, Wils, E.J., Westerloo, D.J. van, Heunks, L.M.A., Schultz, M.J., Paulus, F., Tuinman, P.R., Blok, S.G., Mousa, A., Brouwer, M.G., Grooth, H.J. de, Neto, A.S., Blans, M.J., Boer, S de, Dormans, T., Endeman, H., Roeleveld, T., Scholten, Harm, Slobbe-Bijlsma, E.R. van, Scholten, E., Touw, H.R.W., Ven, F.S.L.I.M. van der, Wils, E.J., Westerloo, D.J. van, Heunks, L.M.A., Schultz, M.J., Paulus, F., and Tuinman, P.R.

Abstract

Item does not contain fulltext, BACKGROUND: Fluid therapy is a common intervention in critically ill patients. It is increasingly recognised that deresuscitation is an essential part of fluid therapy and delayed deresuscitation is associated with longer invasive ventilation and length of intensive care unit (ICU) stay. However, optimal timing and rate of deresuscitation remain unclear. Lung ultrasound (LUS) may be used to identify fluid overload. We hypothesise that daily LUS-guided deresuscitation is superior to deresuscitation without LUS in critically ill patients expected to undergo invasive ventilation for more than 24 h in terms of ventilator free-days and being alive at day 28. METHODS: The "effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients" (CONFIDENCE) is a national, multicentre, open-label, randomised controlled trial (RCT) in adult critically ill patients that are expected to be invasively ventilated for at least 24 h. Patients with conditions that preclude a negative fluid balance or LUS examination are excluded. CONFIDENCE will operate in 10 ICUs in the Netherlands and enrol 1000 patients. After hemodynamic stabilisation, patients assigned to the intervention will receive daily LUS with fluid balance recommendations. Subjects in the control arm are deresuscitated at the physician's discretion without the use of LUS. The primary endpoint is the number of ventilator-free days and being alive at day 28. Secondary endpoints include the duration of invasive ventilation; 28-day mortality; 90-day mortality; ICU, in hospital and total length of stay; cumulative fluid balance on days 1-7 after randomisation and on days 1-7 after start of LUS examination; mean serum lactate on days 1-7; the incidence of reintubations, chest drain placement, atrial fibrillation, kidney injury (KDIGO stadium ≥ 2) and hypernatremia; the use of invasive hemodynamic monitoring, and chest-X-ray; and quality of life at day 28. DISCUSSION: The CONFIDENCE t

Published
2023

27. Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome

Author

Kullberg, Robert F. J., primary, de Brabander, Justin, additional, Boers, Leonoor S., additional, Biemond, Jason J., additional, Nossent, Esther J., additional, Heunks, Leo M. A., additional, Vlaar, Alexander P. J., additional, Bonta, Peter I., additional, van der Poll, Tom, additional, Duitman, JanWillem, additional, Bos, Lieuwe D. J., additional, Wiersinga, W. Joost, additional, Saris, Anno, additional, De Vries, Heder, additional, Meijboom, Lilian J., additional, Blok, Siebe G., additional, Schuurman, Alex R., additional, Reijnders, Tom D.Y., additional, Garcia Vallejo, Juan J., additional, Bontkes, Hetty, additional, Lutter, René, additional, Bogaard, Harm Jan, additional, de Bruin, S., additional, Koning, R., additional, van Agtmael, M.A., additional, Algera, A.G., additional, van Baarle, F.E.H.P., additional, Bax, D.J.C., additional, Beudel, M., additional, Bomers, M., additional, Botta, M., additional, de Bree, G.J., additional, Bugiani, M., additional, Bulle, E.B., additional, Chouchane, O., additional, Cloherty, A.P.M., additional, Elbers, P.E., additional, Fleuren, L.M., additional, Geerlings, S.E., additional, Geerts, B.F., additional, Geijtenbeek, T.B.H., additional, Girbes, A.R.J., additional, Goorhuis, A., additional, Grobusch, M.P., additional, Hafkamp, F.M.J., additional, Hagens, L.A., additional, Hamann, J., additional, Harris, V.C., additional, Hemke, R., additional, Hermans, S.M., additional, Hollmann, M.W., additional, Horn, J., additional, Hovius, J.W., additional, de Jong, M.D., additional, van Mourik, N., additional, Nellen, J.F, additional, Paulus, F., additional, Peters, E., additional, Preckel, B., additional, Raasveld, S.J., additional, Schinkel, M., additional, Schultz, M.J., additional, Sigaloff, K., additional, Smit, M.R., additional, Stijnis, C., additional, Stilma, W., additional, Teunissen, C.E., additional, Thoral, P., additional, Tsonas, A.M., additional, van der Valk, M., additional, Veelo, D.P., additional, van Vugt, M., additional, Wouters, D., additional, Zwinderman, A.H., additional, Brouwer, M.C., additional, and van de Beek, D., additional

Published
2022
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31. Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method

Author

Nasa, P. Azoulay, E. Chakrabarti, A. Divatia, J.V. Jain, R. Rodrigues, C. Rosenthal, V.D. Alhazzani, W. Arabi, Y.M. Bakker, J. Bassetti, M. De Waele, J. Dimopoulos, G. Du, B. Einav, S. Evans, L. Finfer, S. Guérin, C. Hammond, N.E. Jaber, S. Kleinpell, R.M. Koh, Y. Kollef, M. Levy, M.M. Machado, F.R. Mancebo, J. Martin-Loeches, I. Mer, M. Niederman, M.S. Pelosi, P. Perner, A. Peter, J.V. Phua, J. Piquilloud, L. Pletz, M.W. Rhodes, A. Schultz, M.J. Singer, M. Timsit, J.-F. Venkatesh, B. Vincent, J.-L. Welte, T. Myatra, S.N. and Nasa, P. Azoulay, E. Chakrabarti, A. Divatia, J.V. Jain, R. Rodrigues, C. Rosenthal, V.D. Alhazzani, W. Arabi, Y.M. Bakker, J. Bassetti, M. De Waele, J. Dimopoulos, G. Du, B. Einav, S. Evans, L. Finfer, S. Guérin, C. Hammond, N.E. Jaber, S. Kleinpell, R.M. Koh, Y. Kollef, M. Levy, M.M. Machado, F.R. Mancebo, J. Martin-Loeches, I. Mer, M. Niederman, M.S. Pelosi, P. Perner, A. Peter, J.V. Phua, J. Piquilloud, L. Pletz, M.W. Rhodes, A. Schultz, M.J. Singer, M. Timsit, J.-F. Venkatesh, B. Vincent, J.-L. Welte, T. Myatra, S.N.

Abstract

During the current COVID-19 pandemic, health-care workers and uninfected patients in intensive care units (ICUs) are at risk of being infected with SARS-CoV-2 as a result of transmission from infected patients and health-care workers. In the absence of high-quality evidence on the transmission of SARS-CoV-2, clinical practice of infection control and prevention in ICUs varies widely. Using a Delphi process, international experts in intensive care, infectious diseases, and infection control developed consensus statements on infection control for SARS-CoV-2 in an ICU. Consensus was achieved for 31 (94%) of 33 statements, from which 25 clinical practice statements were issued. These statements include guidance on ICU design and engineering, health-care worker safety, visiting policy, personal protective equipment, patients and procedures, disinfection, and sterilisation. Consensus was not reached on optimal return to work criteria for health-care workers who were infected with SARS-CoV-2 or the acceptable disinfection strategy for heat-sensitive instruments used for airway management of patients with SARS-CoV-2 infection. Well designed studies are needed to assess the effects of these practice statements and address the remaining uncertainties. © 2022 Elsevier Ltd

Published
2022

32. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Author

Pisani, L., Algera, A.G., Neto, A.S., Azevedo, Luciano, Pham, T., Paulus, F., Abreu, M.G. de, Pelosi, P., Dondorp, A.M., Bellani, G., Schouten, J.A., Laffey, J.G., Schultz, M.J., Pisani, L., Algera, A.G., Neto, A.S., Azevedo, Luciano, Pham, T., Paulus, F., Abreu, M.G. de, Pelosi, P., Dondorp, A.M., Bellani, G., Schouten, J.A., Laffey, J.G., and Schultz, M.J.

Abstract

Contains fulltext : 252214.pdf (Publisher’s version ) (Open Access), BACKGROUND: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. METHODS: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. FINDINGS: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). T

Published
2022

34. Low Positive End-Expiratory Pressure Ventilation Increases Mechanical Power and Pulmonary Neutrophilic Inflammation in an Experimental Model of Moderate to Severe Acute Lung Injury

Author

Scharffenberg, M., primary, Huhle, R., additional, Wittenstein, J., additional, Ran, X., additional, Zhang, Y., additional, Braune, A., additional, Theilen, R., additional, Maiello, L., additional, Benzi, G., additional, Pelosi, P., additional, Rocco, P.R.M., additional, Schultz, M.J., additional, Koch, T., additional, Kotzerke, J., additional, and Gama de Abreu, M., additional

Published
2022
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35. Introduction of a New Model for In Vitro Volatile Organic Compound Detection from Co-Culture of Lung Epithelial Cell Line with Bacteria Commonly Associated with Pulmonary Infections

Author

Fenn, D., primary, Ahmed, W.M., additional, Tuip-de Boer, A., additional, Lilien, T., additional, Brinkman, P., additional, Neerincx, A.H., additional, Fowler, S.J., additional, Schultz, M.J., additional, Maitland-van der Zee, A.H., additional, and Bos, L.D.J., additional

Published
2022
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36. Untargeted 16s Gene Sequencing Versus Culture of Broncho-Alveolar Lavage Fluid for the Diagnosis of Ventilator Associated Pneumonia

Author

Fenn, D., primary, Ibrahim, M., additional, van Oort, P.M.P., additional, Brinkman, P., additional, Ahmed, W.A., additional, Felton, T., additional, Artigas, A., additional, Póvoa, P., additional, Martin-Loeches, I., additional, Schultz, M.J., additional, Dark, P., additional, Fowler, S.J., additional, and Bos, L.D.J., additional

Published
2022
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37. Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

Author

Roozeman, Jan-Paul, primary, Mazzinari, Guido, additional, Serpa Neto, Ary, additional, Hollmann, Markus W., additional, Paulus, Frederique, additional, Schultz, Marcus J., additional, Pisani, Luigi, additional, Algera, A.G., additional, Boers, L.S., additional, Bos, L.D.J., additional, Botta, M., additional, Dongelmans, D.A., additional, Hollmann, M.W., additional, Horn, J., additional, Paulus, F., additional, Pillay, J., additional, Schultz, M.J., additional, Neto, A. Serpa, additional, Tsonas, A.M., additional, Vlaar, A.P.J., additional, Ahuja, S., additional, van Akkeren, J.P., additional, Algoe, C.K., additional, van Amstel, R.B., additional, Artigas, A., additional, Baur, O.L., additional, van de Berg, P., additional, van den Berg, A.E., additional, Bergmans, D.C.J.J., additional, van den Bersselaar, D.I., additional, Bertens, F.A., additional, Bindels, A.J.G.H., additional, de Boer, M.M., additional, den Boer, S., additional, Bogerd, M., additional, Breel, J.S., additional, de Bruin, H., additional, de Bruin, S., additional, Bruna, C.L., additional, Buiteman-Kruizinga, L.A., additional, Cremer, O.L., additional, Determann, R.M., additional, Dieperink, W., additional, Franke, H.S., additional, Galek-Aldridge, M.S., additional, de Graaff, M.J., additional, Hagens, L.A., additional, Haringman, J.J., additional, van der Heide, S.T., additional, van der Heiden, P.L.J., additional, Heijnen, N.F.L., additional, Hiel, S.J.P., additional, Hoeijmakers, L.L., additional, Hol, L., additional, Hoogendoorn, M.E., additional, van der Horst, R., additional, Ie, E.L.K., additional, Ivanov, D., additional, Juffermans, N.P., additional, Kho, E., additional, de Klerk, E.S., additional, Gemert, A.W.M.M. Koopman-van, additional, Koopmans, M., additional, Kucukcelebi, S., additional, Kuiper, M.A., additional, de Lange, D.W., additional, van Mourik, N., additional, Nijbroek, S.G., additional, Onrust, M., additional, Oostdijk, E.A.N., additional, Pennartz, C.J., additional, Pisani, L., additional, Purmer, I.M., additional, Rettig, T.C.D., additional, Roozeman, J.P., additional, Schuijt, M.T.U., additional, Sleeswijk, M.E., additional, Smit, M.R., additional, Spronk, P.E., additional, Stilma, W., additional, Strang, A.C., additional, Tuinman, P.R., additional, Valk, C.M.A., additional, Veen-Schra, F.L., additional, Veldhuis, L.I., additional, van Velzen, P., additional, van der Ven, W.H., additional, van Vliet, P., additional, van der Voort, P.H.J., additional, van Welie, L., additional, Wesselink, H.J.F.T., additional, van der Wier-Lubbers, H.H., additional, van Wijk, B., additional, Winters, T., additional, Wong, W.Y., additional, and van Zanten, A.R.H., additional

Published
2022
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41. Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

Author

Bos, Lieuwe D J, primary, Sjoding, Michael, additional, Sinha, Pratik, additional, Bhavani, Sivasubramanium V, additional, Lyons, Patrick G, additional, Bewley, Alice F, additional, Botta, Michela, additional, Tsonas, Anissa M, additional, Serpa Neto, Ary, additional, Schultz, Marcus J, additional, Dickson, Robert P, additional, Paulus, Frederique, additional, van Akkeren, J.P., additional, Algera, A.G., additional, Algoe, C.K., additional, van Amstel, R.B., additional, Artigas, A., additional, Baur, O.L., additional, van de Berg, P., additional, van den Berg, A.E., additional, Bergmans, D.C.J.J., additional, van den Bersselaar, D.I., additional, Bertens, F.A., additional, Bindels, A.J.G.H., additional, de Boer, M.M., additional, den Boer, S., additional, Boers, L.S., additional, Bogerd, M., additional, Bos, L.D.J., additional, Botta, M., additional, Breel, J.S., additional, de Bruin, H., additional, de Bruin, S., additional, Bruna, C.L., additional, Buiteman-Kruizinga, L.A., additional, Cremer, O., additional, Determann, R.M., additional, Dieperink, W., additional, Dongelmans, D.A., additional, Franke, H.S., additional, Galek-Aldridge, M.S., additional, de Graaff, M.J., additional, Hagens, L.A., additional, Haringman, J.J., additional, van der Heide, S.T., additional, van der Heiden, P.L.J., additional, Heijnen, N.F.L., additional, Hiel, S.J.P., additional, Hoeijmakers, L.L., additional, Hol, L., additional, Hollmann, M.W., additional, Hoogendoorn, M.E., additional, Horn, J., additional, van der Horst, R., additional, Ie, E.L.K., additional, Ivanov, D., additional, Juffermans, N.P., additional, Kho, E., additional, de Klerk, E.S., additional, Koopman-van Gemert, A.W.M.M., additional, Koopmans, M., additional, Kucukcelebi, S., additional, Kuiper, M.A., additional, de Lange, D.W., additional, Martin-Loeches, I., additional, Mazzinari, G., additional, van Meenen, D.M.P., additional, Morales-Quinteros, L., additional, van Mourik, N., additional, Nijbroek, S.G., additional, Onrust, M., additional, Oostdijk, E.A.N., additional, Paulus, F., additional, Pennartz, C.J., additional, Pillay, J., additional, Pisani, L., additional, Purmer, I.M., additional, Rettig, T.C.D., additional, Roozeman, J.P., additional, Schuijt, M.T.U., additional, Schultz, M.J., additional, Serpa Neto, A., additional, Sleeswijk, M.E., additional, Smit, M.R., additional, Spronk, P.E., additional, Stilma, W., additional, Strang, A.C., additional, Tsonas, A.M., additional, Tuinman, P.R., additional, Valk, C.M.A., additional, Veen-Schra, F.L., additional, Veldhuis, L.I., additional, van Velzen, P., additional, van der Ven, W.H., additional, Vlaar, A.P.J., additional, van Vliet, P., additional, van der Voort, P.H.J., additional, van Welie, L., additional, Wesselink, H.J.F.T., additional, van der Wier-Lubbers, H.H., additional, van Wijk, B., additional, Winters, T., additional, Wong, W.Y., additional, and van Zanten, A.R.H., additional

Published
2021
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43. Imatinib in patients with severe COVID-19: a randomised, doubleblind, placebo-controlled, clinical trial (vol 9, pg 957, 2021)

Author

Aman, J., Duijvelaar, E., Botros, L., Kianzad, A., Schippers, J.R., Smeele, P.J., Azhang, S., Bartelink, I.H., Bayoumy, A.A., Bet, P.M., Boersma, W., Bonta, P.I., Boomars, K.A.T., Bos, L.D.J., Bragt, J.J.M.H. van, Braunstahl, G.J., Celant, L.R., Eger, K.A.B., Geelhoed, J.J.M., Glabbeek, Y.L.E. van, Grotjohan, H.P., Hagens, L.A., Happe, C.M., Hazes, B.D., Heunks, L.M.A., Heuvel, M. van den, Hoefsloot, W., Hoek, R.J.A., Hoekstra, R., Hofstee, H.M.A., Juffermans, N.P., Kemper, E.M., Kos, R., Kunst, P.W.A., Lammers, A., Lee, I. van der, Lee, E.L. van der, Maitland-van der Zee, A.H., Asam, P.F.M.M., Mieras, A., Muller, M., Neefjes, E.C.W., Nossent, E.J., Oswald, L.M.A., Overbeek, M.J., Pamplona, C.C., Paternotte, N., Pronk, N., Raaf, M.A. de, Raaij, B.F.M. van, Reijrink, M., Schultz, M.J., Neto, A.S., Slob, E.M.A., Smeenk, F.W.J.M., Smit, M.R., Smits, A.J., Stalenhoef, J.E., Tuinman, P.R., Vanhov, A.L.E.M., Wessels, J.N., Wezenbeek, J.C.C. van, Noordegraaf, A.V., Ma, F.S. de, and Bogaard, H.J.

Published
2021

44. Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study

Author

Schuijt, Michiel T.U., primary, Martin-Loeches, Ignacio, additional, Schultz, Marcus J., additional, Paulus, Frederique, additional, Neto, Ary Serpa, additional, van Akkeren, J.P., additional, Algera, A.G., additional, Algoe, C.K., additional, van Amstel, R.B., additional, Baur, O.L., additional, van de Berg, P., additional, van den Berg, A.E., additional, Bergmans, D.C.J.J., additional, van den Bersselaar, D.I., additional, Bertens, F.A., additional, Bindels, A.J.G.H., additional, de Boer, M.M., additional, den Boer, S., additional, Boers, L.S., additional, Bogerd, M., additional, Bos, L.D.J., additional, Botta, M., additional, Breel, J.S., additional, de Bruin, H., additional, de Bruin, S., additional, Bruna, C.L., additional, Buiteman-Kruizinga, L.A., additional, Cremer, O., additional, Determann, R.M., additional, Dieperink, W., additional, Dongelmans, D.A., additional, Franke, H.S., additional, Aldridge, M.S. Galek, additional, de Graaff, M.J., additional, Hagens, L.A., additional, Haringman, J.J., additional, Heijnen, N.F.L., additional, Hiel, S., additional, van der Heide, S.T., additional, van der Heiden, P.L.J., additional, Hoeijmakers, L.L., additional, Hol, L., additional, Hollmann, M.W., additional, Hoogendoorn, M.E., additional, Horn, J., additional, van der Horst, R., additional, Ie, E.L.K., additional, Ivanov, D., additional, Juffermans, N.P., additional, Kho, E., additional, de Klerk, E.S., additional, Koopman, A.W.M., additional, Koopmans, M., additional, Kucukcelebi, S., additional, Kuiper, M.A., additional, de Lange, D.W., additional, van Mourik, N., additional, Martin-Loeches, I., additional, Nijbroek, S.G., additional, Onrust, M., additional, Oostdijk, E.A.N., additional, Paulus, F., additional, Pennartz, C.J., additional, Pillay, J., additional, Pisani, L., additional, Purmer, I.M., additional, Rettig, T.C.D., additional, Roozeman, J.P., additional, Schuijt, M.T.U., additional, Schultz, M.J., additional, Neto, A. Serpa, additional, Sleeswijk, M.E., additional, Smit, M.R., additional, Spronk, P.E., additional, Stilma, W., additional, Strang, A.C., additional, Tsonas, A.M., additional, Tuinman, P.R., additional, Valk, C.M.A., additional, Veen, F.L., additional, Vlaar, A.P.J., additional, Veldhuis, L.I., additional, van Velzen, P., additional, van der Ven, W.H., additional, van Vliet, P., additional, van der Voort, P., additional, van der Wier, H.H., additional, van Welie, L., additional, Wesselink, H.J.F.T., additional, van Wijk, B., additional, Winters, T., additional, Wong, W.Y., additional, and van Zanten, A.R.H., additional

Published
2021
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46. Prognostication using SpO2/FiO2in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

Author

Roozeman, Jan-Paul, Mazzinari, Guido, Serpa Neto, Ary, Hollmann, Markus W., Paulus, Frederique, Schultz, Marcus J., Pisani, Luigi, Algera, A.G., Boers, L.S., Bos, L.D.J., Botta, M., Dongelmans, D.A., Hollmann, M.W., Horn, J., Paulus, F., Pillay, J., Schultz, M.J., Neto, A. Serpa, Tsonas, A.M., Vlaar, A.P.J., Botta, M., Tsonas, A.M., Ahuja, S., van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O.L., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Neto, A. Serpa, Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., Vlaar, A.P.J., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., and van Zanten, A.R.H.

Abstract

The SpO2/FiO2is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2for mortality in patients with ARDS due to COVID–19.

Published
2022
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47. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Author

Bastard, P. Gervais, A. Voyer, T.L. Rosain, J. Philippot, Q. Manry, J. Michailidis, E. Hoffmann, H.-H. Eto, S. Garcia-Prat, M. Bizien, L. Parra-Martínez, A. Yang, R. Haljasmägi, L. Migaud, M. Särekannu, K. Maslovskaja, J. De Prost, N. Tandjaoui-Lambiotte, Y. Luyt, C.-E. Amador-Borrero, B. Gaudet, A. Poissy, J. Morel, P. Richard, P. Cognasse, F. Troya, J. Trouillet-Assant, S. Belot, A. Saker, K. Garçon, P. Rivière, J.G. Lagier, J.-C. Gentile, S. Rosen, L.B. Shaw, E. Morio, T. Tanaka, J. Dalmau, D. Tharaux, P.-L. Sene, D. Stepanian, A. Megarbane, B. Triantafyllia, V. Fekkar, A. Heath, J.R. Franco, J.L. Anaya, J.-M. Solé-Violán, J. Imberti, L. Biondi, A. Bonfanti, P. Castagnoli, R. Delmonte, O.M. Zhang, Y. Snow, A.L. Holland, S.M. Biggs, C.M. Moncada-Vélez, M. Arias, A.A. Lorenzo, L. Boucherit, S. Coulibaly, B. Anglicheau, D. Planas, A.M. Haerynck, F. Duvlis, S. Nussbaum, R.L. Ozcelik, T. Keles, S. Bousfiha, A.A. El Bakkouri, J. Ramirez-Santana, C. Paul, S. Pan-Hammarström, Q. Hammarström, L. Dupont, A. Kurolap, A. Metz, C.N. Aiuti, A. Casari, G. Lampasona, V. Ciceri, F. Barreiros, L.A. Dominguez-Garrido, E. Vidigal, M. Zatz, M. Van De Beek, D. Sahanic, S. Tancevski, I. Stepanovskyy, Y. Boyarchuk, O. Nukui, Y. Tsumura, M. Vidaur, L. Tangye, S.G. Burrel, S. Duffy, D. Quintana-Murci, L. Klocperk, A. Kann, N.Y. Shcherbina, A. Lau, Y.-L. Leung, D. Coulongeat, M. Marlet, J. Koning, R. Reyes, L.F. Chauvineau-Grenier, A. Venet, F. Monneret, G. Nussenzweig, M.C. Arrestier, R. Boudhabhay, I. Baris-Feldman, H. Hagin, D. Wauters, J. Meyts, I. Dyer, A.H. Kennelly, S.P. Bourke, N.M. Halwani, R. Sharif-Askari, N.S. Dorgham, K. Sallette, J. Sedkaoui, S.M. AlKhater, S. Rigo-Bonnin, R. Morandeira, F. Roussel, L. Vinh, D.C. Ostrowski, S.R. Condino-Neto, A. Prando, C. Bondarenko, A. Spaan, A.N. Gilardin, L. Fellay, J. Lyonnet, S. Bilguvar, K. Lifton, R.P. Mane, S. Anderson, M.S. Boisson, B. Béziat, V. Zhang, S.-Y. Andreakos, E. Hermine, O. Pujol, A. Peterson, P. Mogensen, T.H. Rowen, L. Mond, J. Debette, S. De Lamballerie, X. Duval, X. Mentré, F. Zins, M. Soler-Palacin, P. Colobran, R. Gorochov, G. Solanich, X. Susen, S. Martinez-Picado, J. Raoult, D. Vasse, M. Gregersen, P.K. Piemonti, L. Rodríguez-Gallego, C. Notarangelo, L.D. Su, H.C. Kisand, K. Okada, S. Puel, A. Jouanguy, E. Rice, C.M. Tiberghien, P. Zhang, Q. Cobat, A. Abel, L. Casanova, J.-L. Alavoine, L. Behillil, S. Burdet, C. Charpentier, C. Dechanet, A. Descamps, D. Ecobichon, J.-L. Enouf, V. Frezouls, W. Houhou, N. Kafif, O. Lehacaut, J. Letrou, S. Lina, B. Lucet, J.-C. Manchon, P. Nouroudine, M. Piquard, V. Quintin, C. Thy, M. Tubiana, S. Van Der Werf, S. Vignali, V. Visseaux, B. Yazdanpanah, Y. Chahine, A. Waucquier, N. Migaud, M.-C. Deplanque, D. Djossou, F. Mergeay-Fabre, M. Lucarelli, A. Demar, M. Bruneau, L. Gerardin, P. Maillot, A. Payet, C. Laviolle, B. Laine, F. Paris, C. Desille-Dugast, M. Fouchard, J. Malvy, D. Nguyen, D. Pistone, T. Perreau, P. Gissot, V. Le Goas, C. Montagne, S. Richard, L. Chirouze, C. Bouiller, K. Desmarets, M. Meunier, A. Lefevre, B. Jeulin, H. Legrand, K. Lomazzi, S. Tardy, B. Gagneux-Brunon, A. Bertholon, F. Botelho-Nevers, E. Christelle, K. Nicolas, L. Roufai, L. Amat, K. Couffin-Cadiergues, S. Esperou, H. Hendou, S. Townsend, L. Cheallaigh, C.N. Bergin, C. Martin-Loeches, I. Dunne, J. Conlon, N. O'Farrelly, C. Abad, J. Accordino, G. Achille, C. Aguilera-Albesa, S. Aguilo-Cucurull, A. Ozkan, E.A. Darazam, I.A. Albisures, J.A.R. Aldave, J.C. Ramos, M.A. Khan, T.A. Aliberti, A. Nadji, S.A. Alkan, G. AlKhater, S.A. Allardet-Servent, J. Allende, L.M. Alonso-Arias, R. Alshahrani, M.S. Alsina, L. Alyanakian, M.-A. Borrero, B.A. Amoura, Z. Antoli, A. Aubart, M. Auguet, T. Avramenko, I. Aytekin, G. Azot, A. Bahram, S. Bajolle, F. Baldanti, F. Baldolli, A. Ballester, M. Feldman, H.B. Barrou, B. Barzaghi, F. Basso, S. Bayhan, G.I. Bezrodnik, L. Bilbao, A. Blanchard-Rohner, G. Blanco, I. Blandinieres, A. Blazquez-Gamero, D. Bleibtreu, A. Bloomfield, M. Bolivar-Prados, M. Borghesi, A. Borie, R. Botdhlo-Nevers, E. Bousquet, A. Boutolleau, D. Bouvattier, C. Bravais, J. Briones, M.L. Brunner, M.-E. Bruno, R. Bueno, M.R.P. Bukhari, H. Bustamante, J. Agra, J.J.C. Capra, R. Carapito, R. Carrabba, M. Casasnovas, C. Caseris, M. Cassaniti, I. Castelle, M. Castelli, F. De Vera, M.C. Castro, M.V. Catherinot, E. Celik, J.B. Ceschi, A. Chalumeau, M. Charbit, B. Cheng, M.P. Clave, P. Clotet, B. Codina, A. Cohen, Y. Comarmond, C. Combes, A. Comoli, P. Corsico, A.G. Coşkuner, T. Cvetkovski, A. Cyrus, C. Danion, F. Darley, D.R. Das, V. Dauby, N. Dauger, S. De Munter, P. De Pontual, L. Dehban, A. Delplancq, G. Demoule, A. Desguerre, I. Di Sabatino, A. Diehl, J.-L. Dobbelaere, S. Dubost, C. Ekwall, O. Bozdemir, Ş.E. Elnagdy, M.H. Emiroglu, M. Endo, A. Erdeniz, E.H. Aytekin, S.E. Lasa, M.P.E. Euvrard, R. Fabio, G. Faivre, L. Falck, A. Fartoukh, M. Faure, M. Arquero, M.F. Ferrer, R. Ferreres, J. Flores, C. Francois, B. Fumado, V. Fung, K.S.C. Fusco, F. Gagro, A. Solis, B.G. Gaussem, P. Gayretli, Z. Gil-Herrera, J. Gatineau, A.G. Girona-Alarcon, M. Godinez, K.A.C. Goffard, J.-C. Gonzales, N. Gonzalez-Granado, L.I. Gonzalez-Montelongo, R. Guerder, A. Gulhan, B. Gumucio, V.D. Hanitsch, L.G. Gunst, J. Gut, M. Hadjadj, J. Hancerli, S. Hariyan, T. Hatipoglu, N. Heppekcan, D. Hernandez-Brito, E. Ho, P.-K. Holanda-Pena, M.S. Horcajada, J.P. Hraiech, S. Humbert, L. Hung, I.F.N. Iglesias, A.D. Inigo-Campos, A. Jamme, M. Arranz, M.J. Jimeno, M.-T. Jordan, I. Kanik-Yuksek, S. Kara, Y.B. Karahan, A. Karbuz, A. Yasar, K.K. Kasapcopur, O. Kashimada, K. Demirkol, Y.K. Kido, Y. Kizil, C. Kilic, A.O. Koutsoukou, A. Krol, Z.J. Ksouri, H. Kuentz, P. Kwan, A.M.C. Kwan, Y.W.M. Kwok, J.S.Y. Lam, D.S.Y. Lampropoulou, V. Lanternier, F. Le Bourgeois, F. Leo, Y.-S. Lopez, R.L. Levin, M. Levy, M. Levy, R. Li, Z. Lilleri, D. Lima, E.J.A.B. Linglart, A. Lopez-Collazo, E. Lorenzo-Salazar, J.M. Louapre, C. Lubetzki, C. Lung, K.-C. Lye, D.C. Magnone, C. Mansouri, D. Marchioni, E. Marioli, C. Marjani, M. Marques, L. Pereira, J.M. Martin-Nalda, A. Pueyo, D.M. Marzana, I. Mata-Martinez, C. Mathian, A. Matos, L.R.B. Matthews, G.V. Mayaux, J. McLaughlin-Garcia, R. Meersseman, P. Mege, J.-L. Mekontso-Dessap, A. Melki, I. Meloni, F. Meritet, J.-F. Merlani, P. Akcan, O.M. Mezidi, M. Migeotte, I. Millereux, M. Million, M. Mirault, T. Mircher, C. Mirsaeidi, M. Mizoguchi, Y. Modi, B.P. Mojoli, F. Moncomble, E. Melian, A.M. Martinez, A.M. Morange, P.-E. Mordacq, C. Morelle, G. Mouly, S.J. Munoz-Barrera, A. Nafati, C. Nagashima, S. Nakagama, Y. Neven, B. Neves, J.F. Ng, L.F.P. Ng, Y.-Y. Nielly, H. Medina, Y.N. Cuadros, E.N. Ocejo-Vinyals, J.G. Okamoto, K. Oualha, M. Ouedrani, A. Ozkaya-Parlakay, A. Pagani, M. Papadaki, M. Parizot, C. Parola, P. Pascreau, T. Paz-Artal, E. Pedraza, S. Pellecer, N.C.G. Pellegrini, S. De Diego, R.P. Perez-Fernandez, X.L. Philippe, A. Picod, A. De Chambrun, M.P. Piralla, A. Planas-Serra, L. Ploin, D. Poncelet, G. Poulakou, G. Pouletty, M.S. Pourshahnazari, P. Qiu-Chen, J.L. Quentric, P. Rambaud, T. Raoult, V. Rebillat, A.-S. Redin, C. Resmini, L. Ricart, P. Richard, J.-C. Rivet, N. Rocamora-Blanch, G. Rodero, M.P. Rodrigo, C. Rodriguez, L.A. Rodriguez-Palmero, A. Romero, C.S. Rothenbuhler, A. Roux, D. Rovina, N. Rozenberg, F. Ruch, Y. Ruiz, M. Del Prado, M.Y.R. Ruiz-Rodriguez, J.C. Sabater-Riera, J. Saks, K. Salagianni, M. Sanchez, O. Sanchez-Montalva, A. Sanchez-Ramon, S. Schidlowski, L. Schluter, A. Schmidt, J. Schmidt, M. Schuetz, C. Schweitzer, C.E. Scolari, F. Sediva, A. Seijo, L. Seminario, A.G. Seng, P. Senoglu, S. Seppanen, M. Llovich, A.S. Shahrooei, M. Siguret, V. Siouti, E. Smadja, D.M. Smith, N. Sobh, A. Soler, C. Sozeri, B. Stella, G.M. Stepanovskiy, Y. Stoclin, A. Taccone, F. Taupin, J.-L. Tavernier, S.J. Terrier, B. Thiery, G. Thorball, C. Thorn, K. Thumerelle, C. Tipu, I. Tolstrup, M. Tomasoni, G. Toubiana, J. Alvarez, J.T. Tsang, O.T.Y. Tserel, L. Tso, E.Y.K. Tucci, A. Oz, Ş.K.T. Ursini, M.V. Utsumi, T. Uzunhan, Y. Vabres, P. Valencia-Ramos, J. Van Den Rym, A.M. Vandernoot, I. Velez-Santamaria, V. Veliz, S.P.Z. Vidigal, M.C. Viel, S. Vilain, C. Vilaire-Meunier, M.E. Villar-Garcia, J. Vincent, A. Vogt, G. Voiriot, G. Volokha, A. Vuotto, F. Wauters, E. Wu, A.K.L. Wu, T.-C. Yahşi, A. Yesilbas, O. Yildiz, M. Young, B.E. Yukselmiş, U. Zecca, M. Zuccaro, V. Van Praet, J. Lambrecht, B.N. Van Braeckel, E. Bosteels, C. Hoste, L. Hoste, E. Bauters, F. De Clercq, J. Heijmans, C. Slabbynck, H. Naesens, L. Florkin, B. Boulanger, C. Vanderlinden, D. Allavena, C. Andrejak, C. Angoulvant, F. Azoulay, C. Bachelet, D. Bartoli, M. Basmaci, R. Behillill, S. Beluze, M. Benech, N. Benkerrou, D. Bhavsar, K. Bitker, L. Bouadma, L. Bouscambert-Duchamp, M. Paz, P.C. Cervantes-Gonzalez, M. Chair, A. Coelho, A. Cordel, H. Couffignal, C. D'Ortenzio, E. De Montmollin, E. Debard, A. Debray, M.-P. Desvallee, M. Diallo, A. Diouf, A. Dorival, C. Dubos, F. Eloy, P. Epaulard, O. Esposito-Farase, M. Etienne, M. Garot, D. Gault, N. Gaymard, A. Ghosn, J. Gigante, T. Gilg, M. Goehringer, F. Guedj, J. Hoctin, A. Hoffmann, I. Houas, I. Hulot, J.-S. Jaafoura, S. Kaguelidou, F. Kali, S. Kerroumi, Y. Khalil, A. Khan, C. Kimmoun, A. Laouenan, C. Laribi, S. Le, M. Le Bris, C. Le Gac, S. Le Hingrat, Q. Le Mestre, S. Le Nagard, H. Lemaignen, A. Lemee, V. Lescure, F.-X. Levy, Y. Lingas, G. Lucet, J.C. MacHado, M. Mambert, M. Manuel, A. Meziane, A. Mouquet, H. Mullaert, J. Neant, N. Noret, M. Papadopoulos, A. Paul, C. Peiffer-Smadja, N. Peigne, V. Petrov-Sanchez, V. Peytavin, G. Pham, H. Picone, O. Puechal, O. Rosa-Calatrava, M. Rossignol, B. Rossignol, P. Roy, C. Schneider, M. Su, R. Tardivon, C. Tellier, M.-C. Teoule, F. Terrier, O. Timsit, J.F. Tual, C. Vanel, N. Veislinger, A. Wiedemann, A. Danielson, J.J. Dobbs, K. Kashyap, A. Ding, L. Dalgard, C.L. Sottini, A. Quaresima, V. Quiros-Roldan, E. Rossi, C. Bettini, L.R. D'Angio, M. Beretta, I. Montagna, D. Licari, A. Marseglia, G.L. Storgaard, M. Jorgensen, S. Al-Muhsen, S. Al-Mulla, F. Arias, A.A. Bogunovic, D. Bolze, A. Brodin, P. Bryceson, Y. Bustamante, C.D. Butte, M.J. Chakravorty, S. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Desai, M. Drolet, B.A. El Baghdadi, J. Espinosa-Padilla, S. Froidure, A. Henrickson, S.E. Hsieh, E.W.Y. Husebye, E.S. Imai, K. Itan, Y. Jarvis, E.D. Karamitros, T. Ku, C.-L. Ling, Y. Lucas, C.L. Maniatis, T. Marodi, L. Milner, J.D. Mironska, K. Novelli, A. Novelli, G. Renia, L. Resnick, I. Sancho-Shimizu, V. Seppanen, M.R.J. Shahrooei, M. Slaby, O. Tayoun, A.A. Ramaswamy, S. Turvey, S.E. Furkan Uddin, K.M. Uddin, M.J. Von Bernuth, H. Zawadzki, P. Bigio, B. De La Chapelle, A. Chen, J. Chrabieh, M. Liu, D. Nemirowskaya, Y. Cruz, I.M. Materna, M. Pelet, S. Seeleuthner, Y. Thibault, C. Liu, Z. Foti, G. Bellani, G. Citerio, G. Contro, E. Pesci, A. Valsecchi, M.G. Cazzaniga, M. Batten, I. Reddy, C. McElheron, M. Noonan, C. Connolly, E. Fallon, A. Erikstrup, C. Pedersen, O.B. Sorensen, E. Mikkelsen, S. Dinh, K.M. Larsen, M.A.H. Paulsen, I.W. Von Stemann, J.H. Hansen, M.B. Annereau, J.-P. Briseno-Roa, L. Gribouval, O. Pelet, A. Alcover, A. Aschard, H. Bousso, P. Bruhns, P. Cerf-Bensussan, N. Cumano, A. D'Enfert, C. Deriano, L. Dillies, M.-A. Di Santo, J. Dromer, F. Eberl, G. Enninga, J. Gomperts-Boneca, I. Hasan, M. Hedestam, G.K. Hercberg, S. Ingersoll, M.A. Lantz, O. Kenny, R.A. Menager, M. Michel, F. Patin, E. Pellegrini, S. Rausell, A. Rieux-Laucat, F. Rogge, L. Fontes, M. Sakuntabhai, A. Schwartz, O. Schwikowski, B. Shorte, S. Tangy, F. Toubert, A. Touvier, M. Ungeheuer, M.-N. Zimmer, C. Albert, M.L. Van Agtmael, M. Algera, A.G. Appelman, B. Van Baarle, F. Bax, D. Beudel, M. Bogaard, H.J. Bomers, M. Bonta, P. Bos, L. Botta, M. De Brabander, J. De Bree, G. De Bruin, S. Buis, D.T.P. Bugiani, M. Bulle, E. Chouchane, O. Cloherty, A. Dijkstra, M. Dongelmans, D.A. Dujardin, R.W.G. Elbers, P. Fleuren, L. Geerlings, S. Geijtenbeek, T. Girbes, A. Goorhuis, B. Grobusch, M.P. Hafkamp, F. Hagens, L. Hamann, J. Harris, V. Hemke, R. Hermans, S.M. Heunks, L. Hollmann, M. Horn, J. Hovius, J.W. De Jong, M.D. Lim, E.H.T. Van Mourik, N. Nellen, J. Nossent, E.J. Paulus, F. Peters, E. Pina-Fuentes, D.A.I. Van Der Poll, T. Preckel, B. Prins, J.M. Raasveld, J. Reijnders, T. De Rotte, M.C.F.J. Schinkel, M. Schultz, M.J. Schrauwen, F.A.P. Schuurman, A. Schuurmans, J. Sigaloff, K. Slim, M.A. Smeele, P. Smit, M. Stijnis, C.S. Stilma, W. Teunissen, C. Thoral, P. Tsonas, A.M. Tuinman, P.R. Van Der Valk, M. Veelo, D. Volleman, C. De Vries, H. Vught, L.A. Van Vugt, M. Wouters, D. Zwinderman, A.H. Brouwer, M.C. Joost Wiersinga, W. Vlaar, A.P.J. Nadif, R. Goldberg, M. Ozguler, A. Henny, J. Lemonnier, S. Coeuret-Pellicer, M. Le Got, S. Tzourio, C. Dufouil, C. Soumare, A. Lachaize, M. Fievet, N. Flaig, A. Martin, F. Bonneaudeau, B. Cannet, D. Gallian, P. Jeanne, M. Perroquin, M. Hamzeh-Cognasse, H. CoV-Contact Cohort St James's Hospital, SARS CoV2 Interest group COVID Clinicians French COVID Cohort Study Group NIAID Immune Response to COVID Group Danish CHGE COVID Human Genetic Effort HGID Lab COVID-STORM Clinicians NH-COVAIR Study Group The Danish Blood Donor Study (DBDS) Imagine COVID-Group The Milieu Interieur Consortium Amsterdam UMC Covid-19 Biobank CONSTANCES cohort 3C-Dijon Study Cerba HealthCare Etablissement du Sang study group

Abstract

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. © 2021 The Authors, some rights reserved.

Published
2021

48. Effectiveness, safety and efficacy of INTELLiVENT–adaptive support ventilation, a closed–loop ventilation mode for use in ICU patients – a systematic review

Author

Botta, M., primary, Wenstedt, E.F.E., additional, Tsonas, A.M., additional, Buiteman-Kruizinga, L.A., additional, van Meenen, D.M.P., additional, Korsten, H.H.M., additional, Horn, J., additional, Paulus, F., additional, Bindels, A.G.J.H., additional, Schultz, M.J., additional, and De Bie, A.J.R., additional

Published
2021
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49. How doctors actually (do not) involve families in decisions to continue or discontinue life-sustaining treatment in neonatal, pediatric, and adult intensive care: A qualitative study

Author

Akkermans, A. (Aranka), primary, Lamerichs, J.M.W.J. (Joyce), additional, Schultz, M.J. (Marcus), additional, Cherpanath, T.G.V. (Thomas), additional, van Woensel, J.B.M. (Job), additional, van Heerde, M. (Marc), additional, van Kaam, A.H.L.C. (Anton), additional, van de Loo, M.D. (Moniek), additional, Stiggelbout, A.M. (Anne), additional, Smets, E.M.A. (Ellen), additional, and de Vos, M.A. (Mirjam), additional

Published
2021
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50. Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients

Author

Zonneveld, Rens, primary, Jurriaans, Suzanne, additional, van Gool, Tom, additional, Hofstra, Jorrit J., additional, Hekker, Thecla A.M., additional, Defoer, Pien, additional, Broekhuizen-van Haaften, Patricia E., additional, Wentink-Bonnema, Ellen M., additional, Boonkamp, Lynn, additional, Teunissen, Charlotte E., additional, Heijboer, Annemieke C., additional, Martens, Frans, additional, de Bree, Godelieve, additional, van Vugt, Michele, additional, van Houdt, Robin, additional, Schinkel, Janke, additional, de Jong, Menno D., additional, van Agtmael, M., additional, Algera, A.G., additional, van Baarle, F., additional, Bax, D., additional, Beudel, M., additional, Bogaard, H.J., additional, Bomers, M., additional, Bos, L., additional, Botta, M., additional, de Brabander, J., additional, Brouwer, M.C., additional, de Bruin, S., additional, Bugiani, M., additional, Bulle, E., additional, Chouchane, O., additional, Cloherty, A., additional, Elbers, P., additional, Fleuren, L., additional, Geerlings, S., additional, Geerts, B., additional, Geijtenbeek, T., additional, Girbes, A., additional, Goorhuis, A., additional, Grobusch, M.P., additional, Hafkamp, F., additional, Hagens, L., additional, Hamann, J., additional, Harris, V., additional, Hemke, R., additional, Hermans, S.M., additional, Heunks, L., additional, Hollmann, M.W., additional, Horn, J., additional, Hovius, J.W., additional, Koning, R., additional, van Mourik, N., additional, Nellen, J., additional, Paulus, F., additional, Peters, E., additional, van der Poll, T., additional, Preckel, B., additional, Prins, J.M., additional, Raasveld, J., additional, Reijnders, T., additional, Schinkel, M., additional, Schultz, M.J., additional, Schuurman, A., additional, Sigaloff, K., additional, Smit, M., additional, Stijnis, C.S., additional, Stilma, W., additional, Thoral, P., additional, Tsonas, A., additional, van der Valk, M., additional, Veelo, D., additional, Vlaar, A.P.J., additional, de Vries, H., additional, Wiersinga, W.J., additional, Wouters, D., additional, Zwinderman, A.H., additional, and van de Beek, D., additional

Published
2021
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