Search

Your search keyword '"Schubert, Nadja"' showing total 21 results
Start Over Author "Schubert, Nadja"
21 results on '"Schubert, Nadja"'

1. Selective inflammation of the tumor microenvironment and invigorated T cell-mediated tumor control upon induced systemic inactivation of TREX1

Author

Marinkovic, Emilija, primary, Chen, Minyi, additional, Schubert, Nadja, additional, Dar, Elif Dogan, additional, Leung, Janet Y., additional, Lohre, Jack, additional, Sahni, Jennifer M., additional, Tun, Christine, additional, Rajeswaran, Pavithra, additional, Mehlo-Jensen, Tanja, additional, Perng, Olivia A., additional, Hill, C. Mark, additional, Sivakumar, Pallavur V., additional, Barnes, Michael J, additional, Malik, Rohit, additional, Behrendt, Rayk, additional, and Roers, Axel, additional

Published
2024
Full Text
View/download PDF

10. Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Author

Schumann, Tina, primary, Ramon, Santiago Costas, additional, Schubert, Nadja, additional, Mayo, Mohamad Aref, additional, Hega, Melanie, additional, Maser, Katharina Isabell, additional, Ada, Servi-Remzi, additional, Sydow, Lukas, additional, Hajikazemi, Mona, additional, Badstübner, Markus, additional, Müller, Patrick, additional, Ge, Yan, additional, Shakeri, Farhad, additional, Buness, Andreas, additional, Rupf, Benjamin, additional, Lienenklaus, Stefan, additional, Utess, Barbara, additional, Muhandes, Lina, additional, Haase, Michael, additional, Rupp, Luise, additional, Schmitz, Marc, additional, Gramberg, Thomas, additional, Manel, Nicolas, additional, Hartmann, Gunther, additional, Zillinger, Thomas, additional, Kato, Hiroki, additional, Bauer, Stefan, additional, Gerbaulet, Alexander, additional, Paeschke, Katrin, additional, Roers, Axel, additional, and Behrendt, Rayk, additional

Published
2022
Full Text
View/download PDF

11. cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA

Author

Schumann, Tina, primary, Ramon, Santiago Costas, additional, Schubert, Nadja, additional, Mayo, Mohamad Aref, additional, Hega, Melanie, additional, Ada, Servi-Remzi, additional, Sydow, Lukas, additional, Hajikazemi, Mona, additional, Ge, Yan, additional, Badstübner, Markus, additional, Lienenklaus, Stefan, additional, Utess, Barbara, additional, Muhandes, Lina, additional, Haase, Michael, additional, Müller, Luise, additional, Schmitz, Marc, additional, Gramberg, Thomas, additional, Manel, Nicolas, additional, Zillinger, Thomas, additional, Bauer, Stefan, additional, Gerbaulet, Alexander, additional, Paeschke, Katrin, additional, Roers, Axel, additional, and Behrendt, Rayk, additional

Published
2022
Full Text
View/download PDF

12. Genome Replication Is Associated With Release of Immunogenic DNA Waste

Author

Schubert, Nadja, primary, Schumann, Tina, additional, Daum, Elena, additional, Flade, Karolin, additional, Ge, Yan, additional, Hagedorn, Lara, additional, Edelmann, Winfried, additional, Müller, Luise, additional, Schmitz, Marc, additional, Kuut, Gunnar, additional, Hornung, Veit, additional, Behrendt, Rayk, additional, and Roers, Axel, additional

Published
2022
Full Text
View/download PDF

15. Unimpaired Responses to Vaccination With Protein Antigen Plus Adjuvant in Mice With Kit-Independent Mast Cell Deficiency

Author

Schubert, Nadja, primary, Lisenko, Katharina, additional, Auerbach, Christian, additional, Weitzmann, Anke, additional, Ghouse, Shanawaz Mohammed, additional, Muhandes, Lina, additional, Haase, Christa, additional, Häring, Tobias, additional, Schulze, Livia, additional, Voehringer, David, additional, Gunzer, Florian, additional, Müller, Werner, additional, Feyerabend, Thorsten B., additional, Rodewald, Hans-Reimer, additional, Dudeck, Anne, additional, and Roers, Axel, additional

Published
2018
Full Text
View/download PDF

17. I kappa B Kinase 2 Is Essential for IgE-Induced Mast Cell De Novo Cytokine Production but Not for Degranulation

Author

Peschke, Katrin, Weitzmann, Anke, Heger, Klaus, Behrendt, Rayk, Schubert, Nadja, Scholten, Julia, Voehringer, David, Hartmann, Karin, Dudeck, Anne, Schmidt-Supprian, Marc, Roers, Axel, Peschke, Katrin, Weitzmann, Anke, Heger, Klaus, Behrendt, Rayk, Schubert, Nadja, Scholten, Julia, Voehringer, David, Hartmann, Karin, Dudeck, Anne, Schmidt-Supprian, Marc, and Roers, Axel

Abstract

The immunoglobulin E (IgE)-mediated mast cell (MC) response is central to the pathogenesis of type I allergy and asthma. I kappa B kinase 2 (IKK2) was reported to couple IgE-induced signals to MC degranulation by phosphorylating the SNARE protein SNAP23. We investigated MC responses in mice with MC-specific inactivation of IKK2 or NF-kappa B essential modulator (NEMO), or animals with MC-specific expression of a mutant, constitutively active IKK2. We show that the IgE-induced late-phase cytokine response is reduced in mice lacking IKK2 or NEMO in MCs. However, anaphylactic in vivo responses of these animals are not different from those of control mice, and in vitro IKK2-deficient MCs readily phosphorylate SNAP23 and degranulate similarly to control cells in response to allergen or calcium ionophore. Constitutive overactivation of the NF-kappa B pathway has only slight effects on allergen-triggered MC responses. Thus, IKK2 is dispensable for MC degranulation, and the important question how IgE-induced signals trigger MC vesicle fusion remains open.

Published
2014

19. Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response

Author

Behrendt, Rayk, primary, Schumann, Tina, additional, Gerbaulet, Alexander, additional, Nguyen, Laura A., additional, Schubert, Nadja, additional, Alexopoulou, Dimitra, additional, Berka, Ursula, additional, Lienenklaus, Stefan, additional, Peschke, Katrin, additional, Gibbert, Kathrin, additional, Wittmann, Sabine, additional, Lindemann, Dirk, additional, Weiss, Siegfried, additional, Dahl, Andreas, additional, Naumann, Ronald, additional, Dittmer, Ulf, additional, Kim, Baek, additional, Mueller, Werner, additional, Gramberg, Thomas, additional, and Roers, Axel, additional

Published
2013
Full Text
View/download PDF

20. Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

Author

Schumann, Tina, Ramon, Santiago Costas, Schubert, Nadja, Mayo, Mohamad Aref, Hega, Melanie, Maser, Katharina Isabell, Ada, Servi-Remzi, Sydow, Lukas, Hajikazemi, Mona, Badstübner, Markus, Müller, Patrick, Ge, Yan, Shakeri, Farhad, Buness, Andreas, Rupf, Benjamin, Lienenklaus, Stefan, Utess, Barbara, Muhandes, Lina, Haase, Michael, Rupp, Luise, Schmitz, Marc, Gramberg, Thomas, Manel, Nicolas, Hartmann, Gunther, Zillinger, Thomas, Kato, Hiroki, Bauer, Stefan, Gerbaulet, Alexander, Paeschke, Katrin, Roers, Axel, and Behrendt, Rayk

Abstract

Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I interferon–driven inflammatory diseases. In these pathophysiological conditions, activation of the DNA sensor cGAS and IFN production are linked to spontaneous DNA damage. Physiological, or tonic, IFN signaling on the other hand is essential to functionally prime nucleic acid sensing pathways. Here, we show that low-level chronic DNA damage in mice lacking the Aicardi-Goutières syndrome gene SAMHD1 reduced tumor-free survival when crossed to a p53-deficient, but not to a DNA mismatch repair-deficient background. Increased DNA damage did not result in higher levels of type I interferon. Instead, we found that the chronic interferon response in SAMHD1-deficient mice was driven by the MDA5/MAVS pathway but required functional priming through the cGAS/STING pathway. Our work positions cGAS/STING upstream of tonic IFN signaling in Samhd1-deficient mice and highlights an important role of the pathway in physiological and pathophysiological innate immune priming.

Published
2023
Full Text
View/download PDF

21. Mast-Cell-Derived TNF Amplifies CD8+Dendritic Cell Functionality and CD8+T Cell Priming

Author

Dudeck, Jan, Ghouse, Shanawaz Mohammed, Lehmann, Christian H.K., Hoppe, Anja, Schubert, Nadja, Nedospasov, Sergei A., Dudziak, Diana, and Dudeck, Anne

Abstract

Mast cells are critical promoters of adaptive immunity in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood. Using Mcpt5-CreTNFFL/FLmice, we show here that the absence of TNF exclusively in mast cells impaired the expansion of CD8+T cells upon sensitization and the T-cell-driven adaptive immune response to elicitation. T cells primed in the absence of mast cell TNF exhibited a diminished efficiency to transfer sensitization to naive recipients. Specifically, mast cell TNF promotes CD8+dendritic cell (DC) maturation and migration to draining lymph nodes. The peripherally released mast cell TNF further critically boosts the CD8+T-cell-priming efficiency of CD8+DCs, thereby linking mast cell effects on T cells to DC modulation. Collectively, our findings identify the distinct potential of mast cell TNF to amplify CD8+DC functionality and CD8+T-cell-dominated adaptive immunity, which may be of great importance for immunotherapy and vaccination approaches.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results