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10. Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice

Author

Peterson, Douglas E, O'Shaughnessy, Joyce A, Rugo, Hope S, Elad, Sharon, Schubert, Mark M, Viet, Chi T, Campbell‐Baird, Cynthia, Hronek, Jan, Seery, Virginia, Divers, Josephine, Glaspy, John, Schmidt, Brian L, and Meiller, Timothy F

Subjects
Dental/Oral and Craniofacial Disease, Chronic Pain, Cancer, Pain Research, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Antineoplastic Agents, Breast Neoplasms, Female, Humans, Incidence, Pain, Stomatitis, TOR Serine-Threonine Kinases, mTOR inhibitor, oral mucosal injury, oral mucositis, stomatitis, Biochemistry and Cell Biology, Oncology and Carcinogenesis
Abstract

In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain. The incidence of mIAS varies widely (2-78%). As reported across multiple mTOR inhibitor clinical trials, grade 3/4 toxicity occurs in up to 9% of patients. Managing mTOR-associated oral lesions with topical oral, intralesional, and/or systemic steroids can be beneficial, in contrast to the lack of evidence supporting steroid treatment of oral mucositis caused by high-dose chemotherapy or radiation. However, steroid management is not uniformly efficacious in all patients receiving mTOR inhibitors. Furthermore, technology does not presently exist to permit clinicians to predict a priori which of their patients will develop these lesions. There thus remains a strategic need to define the pathobiology of mIAS, the molecular basis of pain, and risk prediction relative to development of the clinical lesion. This knowledge could lead to novel future interventions designed to more effectively prevent mIAS and improve pain management if clinically significant mIAS lesions develop.

Published
2016

22. Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols

Author

Zecha, Judith A. E. M., Raber-Durlacher, Judith E., Nair, Raj G., Epstein, Joel B., Elad, Sharon, Hamblin, Michael R., Barasch, Andrei, Migliorati, Cesar A., Milstein, Dan M. J., Genot, Marie-Thérèse, Lansaat, Liset, van der Brink, Ron, Arnabat-Dominguez, Josep, van der Molen, Lisette, Jacobi, Irene, van Diessen, Judi, de Lange, Jan, Smeele, Ludi E., Schubert, Mark M., and Bensadoun, René-Jean

Published
2016
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23. Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations

Author

Zecha, Judith A. E. M., Raber-Durlacher, Judith E., Nair, Raj G., Epstein, Joel B., Sonis, Stephen T., Elad, Sharon, Hamblin, Michael R., Barasch, Andrei, Migliorati, Cesar A., Milstein, Dan M. J., Genot, Marie-Thérèse, Lansaat, Liset, van der Brink, Ron, Arnabat-Dominguez, Josep, van der Molen, Lisette, Jacobi, Irene, van Diessen, Judi, de Lange, Jan, Smeele, Ludi E., Schubert, Mark M., and Bensadoun, René-Jean

Published
2016
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25. Sustainability in Wood Products: A New Perspective for Handling Natural Diversity.

Author

Schubert, Mark, Panzarasa, Guido, and Burgert, Ingo

Abstract

Wood is a renewable resource with excellent qualities and the potential to become a key element of a future bioeconomy. The increasing environmental awareness and drive to achieve sustainability is leading to a resurgence of research on wood materials. Nevertheless, the global climate changes and associated consequences will soon challenge the wood-value chains in several regions (e.g., central Europe). To cope with these challenges, it is necessary to rethink the current practice of wood sourcing and transformation. The goal of this review is to address the intrinsic natural diversity of wood, from its origin to its technological consequences for the present and future manufacturing of wood products. So far, industrial processes have been optimized to repress the variability of wood properties, enabling more efficient processing and production of reliable products. However, the need to preserve biodiversity and the impact of climate change on forests call for new wood processing techniques and green chemistry protocols for wood modification as enabling factors necessary for managing a more diverse wood provision in the future. This article discusses the past developments that have resulted in the current wood value chains and provides a perspective about how natural variability could be turned into an asset for making truly sustainable wood products. After briefly introducing the chemical and structural complexity of wood, the methods conventionally adopted for industrial homogenization and modification of wood are discussed in relation to their evolution toward increased sustainability. Finally, a perspective is given on technological potentials of machine learning techniques and of novel functional wood materials. Here the main message is that through a combination of sustainable forestry, adherence to green chemistry principles and adapted processes based on machine learning, the wood industry could not only overcome current challenges but also thrive in the near future despite the awaiting challenges. [ABSTRACT FROM AUTHOR]

Published
2023
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30. A Multicenter Pilot Evaluation of the National Institutes of Health Chronic Graft-versus-Host Disease (cGVHD) Therapeutic Response Measures: Feasibility, Interrater Reliability, and Minimum Detectable Change

Author

Mitchell, Sandra A., Jacobsohn, David, Thormann Powers, Kimberly E., Carpenter, Paul A., Flowers, Mary E.D., Cowen, Edward W., Schubert, Mark, Turner, Maria L., Lee, Stephanie J., Martin, Paul, Bishop, Michael R., Baird, Kristin, Bolaños-Meade, Javier, Boyd, Kevin, Fall-Dickson, Jane M., Gerber, Lynn H., Guadagnini, Jean-Pierre, Imanguli, Matin, Krumlauf, Michael C., Lawley, Leslie, Li, Li, Reeve, Bryce B., Clayton, Janine Austin, Vogelsang, Georgia B., and Pavletic, Steven Z.

Published
2011
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39. Association of Osteonecrosis of the Jaw With Zoledronic Acid Treatment for Bone Metastases in Patients With Cancer

Author

Van Poznak, Catherine H., primary, Unger, Joseph M., additional, Darke, Amy K., additional, Moinpour, Carol, additional, Bagramian, Robert A., additional, Schubert, Mark M., additional, Hansen, Lisa Kathryn, additional, Floyd, Justin D., additional, Dakhil, Shaker R., additional, Lew, Danika L., additional, Wade, James Lloyd, additional, Fisch, Michael J., additional, Henry, N. Lynn, additional, Hershman, Dawn L., additional, and Gralow, Julie, additional

Published
2021
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40. A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation

Author

Schubert, Mark M., Eduardo, Fernanda P., Guthrie, Katherine A., Franquin, Jean-Claude, Bensadoun, Rene-Jean J., Migliorati, Cesar A., Lloid, C. Michele E., Eduardo, Carlos P., Walter, Niccoli-Filho, Marques, Marcia M., and Hamdi, Mohd

Published
2007
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42. Enzyme immobilization inside the porous wood structure: A natural scaffold for continuous-flow biocatalysis

Author

Goldhahn, Christian, Taut, Josef A., Schubert, Mark, Burgert, Ingo, and Chanana, Munish

Abstract

Enzymes are often immobilized on solid supports to enable their recovery from reaction solutions, facilitate their reuse and hence increase cost-effectiveness in their application. Immobilized enzymes may even be used for flow-through applications in continuous processes. However, the synthesis of traditional immobilization scaffolds and immobilization techniques lack sustainability as they are often based on fuel-based materials and tedious synthesis- and immobilization approaches. Here, we present the natural material wood as a green alternative for enzyme immobilization. Its natural structure provides a mechanically stable porous scaffold with a high inner surface area that allows for directional flow-through of liquids. Enzymes were immobilized by nanoparticle-mediated adsorption, a simple, versatile and completely water-based process. The resulting wood–enzyme hybrids were intensely investigated for the model enzyme laccase. Reaction kinetics, as well as catalytic activities at various pH-values, temperatures, and ionic strengths were determined. The wood–enzyme hybrids could quickly and completely be removed from the reaction solution. Hence, they allow for multifold reusability. We show a series of 25 consecutive reaction cycles with a remaining activity in the last cycle of 90% of the maximal activity. Moreover, the anisotropic porosity of wood enabled the application of the hybrid material as a biocatalytic flow-through reactor. Flow-rate dependent productivity of a single-enzyme reaction was determined. Moreover, we show a two-step reaction cascade in continuous flow by the immobilization of the enzymes glucose oxidase and horseradish peroxidase. Therefore, the natural material wood proved to be a promising material for application in continuous-flow biocatalysis., RSC Advances, 10 (35), ISSN:2046-2069

Published
2020

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