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123 results on '"Schrott, Lisa"'

1. Mitigating Behavioral Biases: The Role of Financial Literacy in Investment Decisions

Author

Schrott, Lisa and Schrott, Lisa

Abstract

This master thesis discusses the impact of overconfidence, home bias and anchoring on investment decisions and examines the role of financial literacy in mitigating the biases. Results found surprisingly high financial knowledge scores in comparison to the existing literature. A positive home bias and anchoring score were found; in contrast, an average negative overconfidence score was found, indicating that participants on average were underconfident regarding their financial knowledge. Gender differences were found for all three biases, with lower confidence levels and higher home bias and anchoring scores for women. Linear regression models were used to examine the relationship between financial literacy and the bias levels. Results found a positive relationship for overconfidence and a negative effect for home bias and anchoring. Statistical tests therefore found an increase in confidence for participants with a higher FL score. In contrast, an increase in FL led to a decrease in domestic assets in the portfolio and led to financial decision-making being less influenced by external information., Masterarbeit Universität Innsbruck 2024

Published
2024

7. Nanoparticle-Encapsulated Bryostatin-1 Activates α-Secretase and PKC Isoforms In vitro and Facilitates Acquisition and Retention of Spatial Learning in an Alzheimer's Disease Mouse Model

Author

Schrott, Lisa, primary, Yi, Ping, additional, Jackson, Kasey, additional, Jackson, Gabriel S., additional, Webb, Christopher, additional, Minagar, Alireza, additional, Yun, J. Winny, additional, Purdum, Geoffrey, additional, Rios, David J., additional, Tyler, Theodore A., additional, Vizcanio, Maria I., additional, Castor, Judith L., additional, Castor, Trevor, additional, and Alexander, Jonathan S., additional

Published
2021
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18. Nanoparticle-Encapsulated Bryostatin-1 Activates α-Secretase and PKC Isoforms In vitro and Facilitates Acquisition and Retention of Spatial Learning in an Alzheimer's Disease Mouse Model

Author

Schrott, Lisa, Yi, Ping, Jackson, Kasey, Jackson, Gabriel S., Webb, Christopher, Minagar, Alireza, Yun, J. W., Purdum, Geoffrey, Rios, David J., Tyler, Theodore A., Vizcanio, Maria I., Castor, Judith L., Castor, Trevor, and Alexander, Jonathan S.

Abstract

Background: Alzheimer’s disease (AD) animal models have revealed neuroprotective actions of Bryostatin-1 mediated by activation of novel PKC isoforms, suppression of beta-amyloid and downregulation of inflammatory and angiogenic events, making Bryostatin-1 an attractive candidate for attenuating AD-associated neural, vascular, and cognitive disturbances. Objective: To further enhance Bryostatin-1 efficacy, nanoparticle-encapsulated Bryostatin-1 formulations were prepared. Methods: We compared nano-encapsulated and unmodified Bryostatin-1 in in vitro models of neuronal PKC-d, PKC-e isoforms, α-secretase and studied nano-encapsulated Bryostatin-1 in an AD mouse model of spatial memory (BC3-Tg (APPswe, PSEN1 dE9) 85Dbo/J mice). Results: We found that nanoencapsulated Bryostatin-1 formulations displayed activity greater or equal to that of unmodified Bryostatin-1 in PKC-δ and -ε and α-secretase activation assays. We next evaluated how treatment with a nanoencapsulated Bryostatin-1 formulation facilitated spatial learning in the Morris water maze. AD transgenic mice (6.5 to 8 months of age) were treated with nanoparticle encapsulated Bryostatin-1 formulation (1, 2.5, or 5 μg/mouse) three times the week before testing and then daily for each of the 5 days of testing. Across the acquisition phase, mice treated with nanoencapsulated Bryostatin-1 had shorter latencies, increased % time in the target zone and decreased % time in the opposite quadrant. The mice were given retention testing after a 2-week period without drug treatment. Mice treated with nanoencapsulated Bryostatin-1 had shorter latencies to find the escape platform, indicating retention of spatial memory. Conclusion: These data suggest that cognitive deficits associated with AD could be treated using highly potent nanoparticle-encapsulated formulations of Bryostatin-1.

Published
2020
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22. Variations in the cerebrospinal fluid proteome following traumatic brain injury and subarachnoid hemorrhage.

Author

JrConnor, David E., Chaitanya, Ganta V., Chittiboina, Prashant, McCarthy, Paul, Scott, L. Keith, Schrott, Lisa, Minagar, Alireza, Nanda, Anil, and Alexander, J. Steven

Subjects
BRAIN injuries, SUBARACHNOID hemorrhage, CEREBROSPINAL fluid, GEL electrophoresis, MATRIX-assisted laser desorption-ionization, HEMOGLOBINS, DIAGNOSIS, PROGNOSIS
Abstract

Background Proteomic analysis of cerebrospinal fluid (CSF) has shown great promise in identifying potential markers of injury in neurodegenerative diseases [1–13] . Here we compared CSF proteomes in healthy individuals, with patients diagnosed with traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) in order to characterize molecular biomarkers which might identify these different clinical states and describe different molecular mechanisms active in each disease state. Methods Patients presenting to the Neurosurgery service at the Louisiana State University Hospital-Shreveport with an admitting diagnosis of TBI or SAH were prospectively enrolled. Patients undergoing CSF sampling for diagnostic procedures were also enrolled as controls. CSF aliquots were subjected to 2-dimensional gel electrophoresis (2D GE) and spot percentage densities analyzed. Increased or decreased spot expression (compared to controls) was defined in terms of in spot percentages, with spots showing consistent expression change across TBI or SAH specimens being followed up by Matrix-Assisted Laser Desorption/Ionization mass spectrometry (MALDI-MS). Polypeptide masses generated were matched to known standards using a search of the NCBI and/or GenPept databases for protein matches. Eight hundred fifteen separately identifiable polypeptide migration spots were identified on 2D GE gels. MALDI-MS successfully identified 13 of 22 selected 2D GE spots as recognizable polypeptides. Results Statistically significant changes were noted in the expression of fibrinogen, carbonic anhydrase-I (CA-I), peroxiredoxin-2 (Prx-2), both α and β chains of hemoglobin, serotransferrin (Tf) and N-terminal haptoglobin (Hp) in TBI and SAH specimens, as compared to controls. The greatest mean fold change among all specimens was seen in CA-I and Hp at 30.7 and −25.7, respectively. TBI specimens trended toward greater mean increases in CA-I and Prx-2 and greater mean decreases in Hp and Tf. Conclusions Consistent CSF elevation of CA-I and Prx-2 with concurrent depletion of Hp and Tf may represent a useful combination of biomarkers for the prediction of severity and prognosis following brain injury. [ABSTRACT FROM AUTHOR]

Published
2017
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