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12. Abstracts of short lectures

Author

Rauwald, H. W., Conner, J., Gray, A., Reynolds, T., Waterman, P., Hartmann, T., Adolph, R. -D., Ehmke, A., Sander, H., Toppel, G., Witte, L., Nyiredy, Sz., Sticher, O., Erdelmeier, C. A. J., van Leeuwen, P. A. S., Kinghorn, A. D., Dallenbach-Tölke, K., Wink, M., Hennessy, Deirdre, Hook, Ingrid, Sheridan, Helen, Mersinger, R., Dornauer, H., Reinhard, E., Heide, L., Tabata, M., Knobloch, K., Jansen, H., Müller, B., Adzet, T., Vila, R., Cañigueral, S., Budzianowski, J., Bachmann, P., Czygan, F. -C., de Witte, P., Lemli, J., 't Hart, L. A., van Enckevort, P. H., Labadie, R. P., van der Heijden, R., de Keyzer, H. H. M., Verhey, E. R., Schripsema, J., Harkes, P. A. A., Verpoorte, R., Svendsen, A. Baerheim, Croom, Jr., E. M., Letchamo, W., Vömel, A., Bauer, R., Wray, V., Wagner, H., Marston, A., Hostettmann, K., Andersson, L., Bohlin, L., Iorizzi, M., Riccio, R., Minale, L., Moreno-Lopez, J., van Beek, T. A., van Bokhoven, H., Kraus, J., Blaschek, W., Franz, G., van den Berg, A. J. J., Radema, M. H., Corthout, J., Pieters, L., Claeys, M., Vanden Berghe, D., Vlietinck, A. J., Dungen, F. M. v. d., Vermeulen, N. P. E., Fischer, F. C., Gijbels, M. J. H., Caspers, P. W. J., Gijbels, M. J. M., Fung, S. Y., Herrebout, W. M., van Gelder, W. M. J., van der Graaf, G. M., Pennings, E. J. M., Huizer, H., van Zuilen, K., Kosasi, S., van der Leer, T., ten Hoope, S. M., van der Nat, J. M., van der Sluis, W. G., Bosch, R. v. d., Duine, J. A., Heijden, R. v. d., Leer, T. v. d., Pieters, L. A., Totté, J., Saleh, M. M., Abbas, R. Z., Zwaving, J. H., Sarer, E., Looman, A., Scheffer, J. J. C., Meijer, A. H., Langezaal, C. R., Simons, J. M., Hoof, L. Van, Vanden Berghe, D. A., Woerdenbag, H. J., Hendriks, H., van der Berg, K., van Stralen, R., Malingré, Th. M., Konings, A. W. T., Lemstra, W., Abdo, S., De Bernardi, M., Marinoni, G., Samaniego, S., Mellerio, G., Vidari, G., Adjibadé, Y., Kuballa, B., Cabalion, P., Anton, R., Ibáñez, C., Monasterio, I., Ayoub, S. M. Hussein, Yankov, L. K., Ovtcharov, R. O., Bartsch, C., BaŞaran, A. A., Calis, I., Nishibe, S., Berger, S., Junior, P., Kopanski, L., Beuscher, N., Billeter, M., Meier, B., Döll, M., Braunewell, H., Skrzypczak, L., Wesolowska, M., Gross, G. A., Winkler, T., Colombo, M. L., Tome, F., Crespi-Perellino, N., Guicciardi, A., Minghetti, A., Speroni, E., Vincieri, F., Vita-Finzi, P., Gabetta, B., Scilingo, A., Dorsaz, A. C., Hostettmann, M., Ebert, M., Economou, D., Nahrstedt, A., Schiebel, H. -M., McDowell, M., Eich, E., Kohaupt, G., Stopp, K., Maidhof, A., Müller, W. E. G., Schade, P., Müllen, K., Eilert, U., Wolters, B., El Tanbouly, N., Beck, J. P., Hanna, S., El Alfy, T., Ersöz, T., Chulia, A. J., Garcia, J., Frahm, A. W., Beutner, D., Gautier, P., Shongo, D., Vekemans, X., Van Koninckxloo, M., Van Haelen, M., Lefébvre, C., Gehrmann, B., Kraus, Lj., Giger, E., Baumann, T. W., Heinzer, F., Meusy, J. -P., Chavanne, M., Glombitza, K. -W., Knöss, W., Deutscher, B., Piepenbrink, G., Peter, J., Greinwald, R., Schultze, W., Gundidza, Mazuru, Hölzl, J., Hess, S., Holm, Y., Aho, E., Holopainen, M., Järvelä, K., Seppänen, T., von Schantz, M., Huhtikangas, A., Lapinjoki, S., Veräjänkorva, H., Heiskanen, J., Kauppinen, V., Lounasmaa, M., Huovinen, K., Härmälä, P., Ottoila, P., Jerga, Chr, Merfort, I., Willuhn, G., Jiménez, A., Manez, S., Villar, A., Kahlos, K., Kiviranta, J., Karppanen, H., Huovinen, H., Koch, A., Kreis, H., May, U., Kuštrak, P., Pepeljnjak, S., Antolić, A., Blažević, N., Laakso, I., Ekundayo, O., Oguntimein, B., Lorentzen, Bente, Rørdam, Anne Marie, Madaus, A., Marcinek, Chr, Martinelli, E. M., Seraglia, R., Briquez, M., Reginault, P., Máthé, Jr., I., Máthé, I., Máthé, A., Meiss, P., Meng, Qingchang, Zhu, Naijue, Chen, Weixin, Miething, H., Seger, V., Hänsel, R., Neuhöfer, H., Lurz, G., Noller, P., Oksman-Caldentey, K. -M., Vuorela, H., Isenegger, M., Strauss, A., Pachaly, P., Adnan, A. Z., Lansing, A., Sin, K. S., Pauli, A., Payá, M., Ivorra, M. D., Poginsky, B., Westendorf, J., Marquardt, H., Potterat, O., Stoeckli-Evans, H., Msonthi, J. D., Randriaminahy, M., Proksch, P., Reher, G., Samochowiec, L., Wójcicki, J., Kadlubowska, D., Kownacka, A., Şarer, E., Sayron-Atasü, E., Cihangir, V., Schmaus, G., Kubeczka, K. -H., Schütz, M., Schulz, G., Stahl-Biskup, E., Seidel, S., Sepasgosarian, J., Laitalainen, T., Światek, L., Grabias, B., Tanker, M., Kurucu, S., Tanker, N., Thron, U., Reichling, J., Martin, R., Vargas, D., Dominguez, X. A., Vollmann, C., Pernilä, H., Nystrand, N., Hinkkanen, R., Walker, J. R. L., Cole, A. L. J., Warncke, D., Kadlubowska, P., Ziegler, S. J., and Zogg, G.

Published
1987
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15. Iridoids from Pentas lanceolata (Forssk.) Deflers

Author

Schripsema, J., Caprini, C.P., van der Heijden, R., Bino, R.J., de Vos, C.H., and Dagnino, D.

Subjects
roots, chemical-constituents, EPS-3, glycosides, rubioideae, phylogeny, PRI Bioscience, longiflora, PRI Management, leaves, Laboratorium voor Plantenfysiologie, PRI Directie, Laboratory of Plant Physiology, rubiaceae
Abstract

From the aerial parts of Pentas lanceolata, belonging to the family Rubiaceae, a series of iridoid glucosides was isolated by preparative HPLC. Seven iridoid glucosides were identified. Besides asperuloside and asperulosidic acid, characteristic iridoids for Rubiaceae, five new iridoids were isolated, namely, tudoside (1), 13R-epi-gaertneroside (2), 13R-epi-epoxygaertneroside (3), and a mixture of E-uenfoside (4) and Z-uenfoside (5). Further, it was shown that the compound reported as citrifolinin B (6) is in fact the same as tudoside and should be revised. Also, the configuration of the previously reported iridoids gaertneroside and epoxygaertneroside has been elucidated.

Published
2007

42. Plasmid CDS5 Influences Infectivity and Virulence in a Mouse Model of Chlamydia trachomatisUrogenital Infection

Author

Ramsey, K. H., Schripsema, J. H., Smith, B. J., Wang, Y., Jham, B. C., O'Hagan, K. P., Thomson, N. R., Murthy, A. K., Skilton, R. J., Chu, P., and Clarke, I. N.

Abstract

ABSTRACTThe native plasmid of both Chlamydia muridarumand Chlamydia trachomatishas been shown to control virulence and infectivity in mice and in lower primates. We recently described the development of a plasmid-based genetic transformation protocol for Chlamydia trachomatisthat for the first time provides a platform for the molecular dissection of the function of the chlamydial plasmid and its individual genes or coding sequences (CDS). In the present study, we transformed a plasmid-free lymphogranuloma venereum isolate of C. trachomatis, serovar L2, with either the original shuttle vector (pGFP::SW2) or a derivative of pGFP::SW2 carrying a deletion of the plasmid CDS5 gene (pCDS5KO). Female mice were inoculated with these strains either intravaginally or transcervically. We found that transformation of the plasmid-free isolate with the intact pGFP::SW2 vector significantly enhanced infectivity and induction of host inflammatory responses compared to the plasmid-free parental isolate. Transformation with pCDS5KO resulted in infection courses and inflammatory responses not significantly different from those observed in mice infected with the plasmid-free isolate. These results indicate a critical role of plasmid CDS5 in in vivofitness and in induction of inflammatory responses. To our knowledge, these are the first in vivoobservations ascribing infectivity and virulence to a specific plasmid gene.

Published
2014
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45. Flavones and flavonol glycosides from Eupatorium cannabinum L.

Author

Elema, E., Schripsema, J., and Malingré, T.

Abstract

The 6-methoxyflavones hispidulin and eupafolin have been identified for the first time from the aerial parts of Eupatorium cannabinum L. The presence of the previously known flavonol glycosides astragalin, kaempferol-3-rutinoside, hyperoside, isoquercitrin and rutin could be confirmed. Hispidulin, eupafolin and rutin were screened for cytotoxicity in vitro. [ABSTRACT FROM AUTHOR]

Published
1989
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46. Intra- and extracellular carbohydrates in plant cell cultures investigated by H-NMR.

Author

Schripsema, J., Erkelens, C., and Verpoorte, R.

Abstract

With the aim of quantifying intra- and extracellular carbohydrates media and cell-extracts from a Tabernaemontana divaricata plant cell-suspension culture were investigated with H-NMR. For suppression of the solvent peak the Meiboom-Gill modification of the Carr-Purcell (CPMG) spin-echo sequence was used after addition of a paramagnetic relaxation agent (Mn) to the sample. Several aspects of this method were optimized (the manganese concentration, the interpulse delay and the number of spin-echo cycles) so as to obtain a rapid and easy method in which no pretreatment of media or cell-extracts was needed. Besides the speed and ease of the method, also the direct identification of carbohydrates and other main components is an advantage. The exhaustion of extracellular carbohydrates was found to coincide with the maximum amount of intracellular carbohydrates. The intracellular carbohydrates, i.e. glucose and fructose, were consumed at a low rate, during several weeks. [ABSTRACT FROM AUTHOR]

Published
1991
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47. Induction of triterpene biosynthesis by elicitors in suspension cultures of Tabernaemontana species.

Author

Heijden, R., Verheij, E., Schripsema, J., Svendsen, A., Verpoorte, R., and Harkes, P.

Abstract

Treatment of suspension cultures of some Tabernaemontana species (Apocynaceae) with elicitors (e.g. cellulase, Candida albicans) result in a rapid de novo production of antimicrobial active triterpenes. The triterpenes are identified as ursene carboxylic acid derivatives. These triterpenes are not produced by an elicited cell suspension culture of Catharanthus roseus, another Apocynaceae. [ABSTRACT FROM AUTHOR]

Published
1988
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49. Expression of Matrix Metalloproteinases Subsequent to Urogenital Chlamydia muridarum Infection of Mice

Author

Ramsey, K.H., Sigar, I.M., Schripsema, J. H., Shaba, N., and Cohoon, K. P.

Abstract

The central hypothesis of this study was that matrix metalloproteinases (MMPs) would be enhanced following murine chlamydial infection and that their expression would vary in mouse strains that differ in their susceptibility to chronic chlamydia-induced disease. To address this hypothesis, female C3H/HeN and C57BL/6 mice were infected intravaginally with Chlamydia muridarum. Uterine and oviduct tissues were assessed for transcription of MMP genes and their tissue inhibitors. An increased activity of MMP genes relative to preinfection tissues was observed in the C3H/HeN mice when compared to C57BL/6 mice. Using gelatin zymography, we detected constitutive MMP-2 activity in both strains of mice but an increase in MMP-9. Casein zymography indicated the presence of two elastase-like activities consistent with MMP-12 and possibly MMP-7. Western blotting and antigen capture enzyme-linked immunoassay also confirmed an increase in MMP-9 but constitutive MMP-2 expression subsequent to the infection in both strains of mice. In C57BL/6 mice, MMP-9 was present in monomer and dimer form throughout the 56-day monitoring period. C3H/HeN mice produced dimeric MMP-9, but increases in the monomer form were also observed through day 14. Post-translational modification of MMP-9 between the two strains also differed. Immunohistochemistry revealed neutrophils as a prominent source for MMP-9 in both strains of mice. We conclude that differences in the relative expression and activity of MMPs, particularly MMP-9, occur in mice differing in their susceptibility to the development of chronic chlamydial disease. These differences may account for disparate outcomes with regard to chronic sequelae of the disease.

Published
2005

50. Expression of Matrix Metalloproteinases Subsequent to Urogenital Chlamydia muridarumInfection of Mice

Author

Ramsey, K.H., Sigar, I.M., Schripsema, J. H., Shaba, N., and Cohoon, K. P.

Abstract

ABSTRACTThe central hypothesis of this study was that matrix metalloproteinases (MMPs) would be enhanced following murine chlamydial infection and that their expression would vary in mouse strains that differ in their susceptibility to chronic chlamydia-induced disease. To address this hypothesis, female C3H/HeN and C57BL/6 mice were infected intravaginally with Chlamydia muridarum. Uterine and oviduct tissues were assessed for transcription of MMP genes and their tissue inhibitors. An increased activity of MMP genes relative to preinfection tissues was observed in the C3H/HeN mice when compared to C57BL/6 mice. Using gelatin zymography, we detected constitutive MMP-2 activity in both strains of mice but an increase in MMP-9. Casein zymography indicated the presence of two elastase-like activities consistent with MMP-12 and possibly MMP-7. Western blotting and antigen capture enzyme-linked immunoassay also confirmed an increase in MMP-9 but constitutive MMP-2 expression subsequent to the infection in both strains of mice. In C57BL/6 mice, MMP-9 was present in monomer and dimer form throughout the 56-day monitoring period. C3H/HeN mice produced dimeric MMP-9, but increases in the monomer form were also observed through day 14. Post-translational modification of MMP-9 between the two strains also differed. Immunohistochemistry revealed neutrophils as a prominent source for MMP-9 in both strains of mice. We conclude that differences in the relative expression and activity of MMPs, particularly MMP-9, occur in mice differing in their susceptibility to the development of chronic chlamydial disease. These differences may account for disparate outcomes with regard to chronic sequelae of the disease.

Published
2005
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