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251 results on '"Schreurs, A. J."'

1. Erratum: Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum

Author

de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Ten Hagen, Timo L M, Prompers, Jeanine J, van Bergen En Henegouwen, Paul M P, Robinson, Dominic J, Oliveira, Sabrina, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Ten Hagen, Timo L M, Prompers, Jeanine J, van Bergen En Henegouwen, Paul M P, Robinson, Dominic J, and Oliveira, Sabrina

Abstract

The authors regret to find an error in the published version of figure 1B, where the graph for 7D12-PS mistakenly was miscopied for 7D12-9G8-PS. During the review process a correct version of Figure 1B was included. The mistake was made while preparing the final text and figures in response to reviewers comments. The authors have revised Figure 1B, and confirm that the correction has no effect on the original data and conclusions. The authors apologize for any inconvenience that the errors may have caused.

Published
2024

2. Erratum: Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum

Author

Sub Cell Biology, Afd Pharmaceutics, Cell Biology, Neurobiology and Biophysics, Pharmaceutics, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Ten Hagen, Timo L M, Prompers, Jeanine J, van Bergen En Henegouwen, Paul M P, Robinson, Dominic J, Oliveira, Sabrina, Sub Cell Biology, Afd Pharmaceutics, Cell Biology, Neurobiology and Biophysics, Pharmaceutics, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Ten Hagen, Timo L M, Prompers, Jeanine J, van Bergen En Henegouwen, Paul M P, Robinson, Dominic J, and Oliveira, Sabrina

Published
2024

14. Cost-effectiveness of FDG-PET in staging non-small cell lung cancer: the PLUS study

Author

Verboom, Paul, van Tinteren, Harm, Hoekstra, Otto S., Smit, Egbert F., van den Bergh, Jan H. A. M., Schreurs, Ad J. M., Stallaert, Roland A. L. M., van Velthoven, Piet C. M., Comans, Emile F. I., Diepenhorst, Fred W., van Mourik, Johan C., Postmus, Pieter E., Boers, Maarten, Grijseels, Els W. M., Teule, Gerrit J. J., Uyl-de Groot, Carin A., and the PLUS study group

Published
2003
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20. Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Author

de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Hagen, Timo L M Ten, Prompers, Jeanine J, Henegouwen, Paul M P van Bergen En, Robinson, Dominic J, Oliveira, Sabrina, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Hagen, Timo L M Ten, Prompers, Jeanine J, Henegouwen, Paul M P van Bergen En, Robinson, Dominic J, and Oliveira, Sabrina

Abstract

Targeted photodynamic therapy (PDT) has the potential to selectively damage tumor tissue and to increase tumor vessel permeability. Here we characterize the tissue biodistribution of two EGFR-targeted nanobody-photosensitizer conjugates (NB-PS), the monovalent 7D12-PS and the biparatopic 7D12-9G8-PS. In addition, we report on the local and acute phototoxic effects triggered by illumination of these NB-PS which have previously shown to lead to extensive tumor damage. Methods: Intravital microscopy and the skin-fold chamber model, containing OSC-19-luc2-cGFP tumors, were used to investigate: a) the fluorescence kinetics and distribution, b) the vascular response and c) the induction of necrosis after illumination at 1 or 24 h post administration of 7D12-PS and 7D12-9G8-PS. In addition, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of a solid tumor model was used to investigate the microvascular status 2 h after 7D12-PS mediated PDT. Results: Image analysis showed significant tumor colocalization for both NB-PS which was higher for 7D12-9G8-PS. Intravital imaging showed clear tumor cell membrane localization 1 and 2 h after administration of 7D12-9G8-PS, and fluorescence in or close to endothelial cells in normal tissue for both NB-PS. PDT lead to vasoconstriction and leakage of tumor and normal tissue vessels in the skin-fold chamber model. DCE-MRI confirmed the reduction of tumor perfusion after 7D12-PS mediated PDT. PDT induced extensive tumor necrosis and moderate normal tissue damage, which was similar for both NB-PS conjugates. This was significantly reduced when illumination was performed at 24 h compared to 1 h after administration. Discussion: Although differences were observed in distribution of the two NB-PS conjugates, both led to similar necrosis. Clearly, the response to PDT using NB-PS conjugates is the result of a complex mixture of tumor cell responses and vascular effects, which is likely to be necessa

Published
2020

21. Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Author

Sub Cell Biology, Sub NMR Spectroscopy, Afd Pharmaceutics, Celbiologie, Pharmaceutics, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Hagen, Timo L M Ten, Prompers, Jeanine J, Henegouwen, Paul M P van Bergen En, Robinson, Dominic J, Oliveira, Sabrina, Sub Cell Biology, Sub NMR Spectroscopy, Afd Pharmaceutics, Celbiologie, Pharmaceutics, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Hagen, Timo L M Ten, Prompers, Jeanine J, Henegouwen, Paul M P van Bergen En, Robinson, Dominic J, and Oliveira, Sabrina

Published
2020

22. Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging

Author

Pathologie, Cancer, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Hagen, Timo L M Ten, Prompers, Jeanine J, Henegouwen, Paul M P van Bergen En, Robinson, Dominic J, Oliveira, Sabrina, Pathologie, Cancer, de Bruijn, Henriette S, Mashayekhi, Vida, Schreurs, Tom J L, van Driel, Pieter B A A, Strijkers, Gustav J, van Diest, Paul J, Lowik, Clemens W G M, Seynhaeve, Ann L B, Hagen, Timo L M Ten, Prompers, Jeanine J, Henegouwen, Paul M P van Bergen En, Robinson, Dominic J, and Oliveira, Sabrina

Published
2020

34. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

Author

Fabbri, Leonardo M., Calverley, Peter M. A., Jose Luis Izquierdo Alonso, Bundschuh, Daniela S., Manja, Brose, Martinez, Fernando J., Rabe, Kf M., Study Groups Abdulla, M., Abdullah, I., Adler, M., Aguilaniu, Albert, I., Almonacid, C., Altés, A., Amaducci, S., Angrill, J., Antonana, J. M., Artner, H., Balint, B., Bantje, T. A., Barbe, F., Bateman, E., Bauchnect, E., Belda, J., Bernabeu, L., Bettendorf, A., Blagden, M., Blanquer, R., Blecher, L., Bonnaud, F., Bourbeau, J., Boyer, G. R., Brotons, C., Bruning, A. H., Bucca, C., Burns, G. E., Von Der Heydt, B. B., Caldwell, Canonica, G. W., Carter, J., Chan, V., Chapman, K. R., Chapman, G., Cheung, D., Chiner, E., Chopra, A., Clini, E., Coulet, P., Craig, B., Croonenborghs, L., Czompó, M., Dal Negro, R. W., Dapper, T., De Graaff, C. S., Ramos Pde, L., De Munck, D. R., Decramer, M., Delobbe, A., Denier, W., De Teresa, L., Dhar, A., Di Maria, G., Dupouy, J., Duschek, G., Echave, J., Esteban, C., Farmer, I. S., Flemale, A., Fletcher, P., Foden, Fouquert, L., Franz, K. H., Frognier, Gagnon, M., Garcia, Mdel M., Garelli, G., Gehling, U., Ginko, T., Glekin, B., Gooding, T., Graham, A., Greillier, P., Greses, J. V., Grillenberger, J., Gross, B., Grygier, H., Gyori, Z., Harper, Henein, S., Heredia, J. L., Hernandez, P., Hoefer, M., Hoffstein, V., Holgate, K., Holler, W., Holub, G., Homik, L., Houle, P. A., Hutter, C., Hyvernat, P., Irusen, E. M., Jackson, A., Janisty, W., Jasnot, J. Y., Joubert, J., Juhasz, G., Jullian, H., Kafe, H., Kelly, P., Kidney, J., Killian, K., Kinch, H., Kirsten, D. L., Kleinecke Pohl, U., Korlipara, K., Krige, L. P., Kroker, A., Kuipers, A. F., Labrecque, M., Larivee, P., Laskowitz, C., Le Merre, C., Lemoigne, F., Ludwig Sengpiel, A., Luengo, M., Luton, R., Macnee, W., Ali, S. M., Maltais, F., Mansur, A., Marciniuk, D., Marin, A., Martin, P., Martinot, J. B., Mazza, F., Bride, M. C., Mcdonald, B., Mckinnon, C., Mclvor, A., Mcnally, D., Mengeot, P. M., Messner, J., Moder, G., Mooney, P., Moretti, A. M., Muller, D., Murio, C., Nardini, S., Nel, A., Ochoa, Saracho Jo, D. E., Paggiaro, P., Paradis, B., Patrick, J., Peche, R., Pellicer, C., Perez, T., Perez, E., De Llano, L. A., Philteos, G., Pieters, W. R., Pigearias, B., Pohl, W., Popovic, R., Prins, M., Querfurt, H., Rajkay, K., Ras, G., Road, J., Roig, J., Roldaan, A. C., Rolke, M., Rozen, D., Sanchez Toril, F., Savani, N., Savary, L., Schiavina, M., Schiesbühl, H., Schreurs, A. J., Schröder Babo, W., Schurmann, W., Seiz, V., Sevette, C., Sharma, R., Shum, C., Damsté, H. E., Smithers, A., Soler, J. J., Steffen, H., Steinhauser, U., Sweilem, M., Tellier, G., Terol, B., Terzano, Claudio, Timar, M., Toma, G., Monserrat, P. T., Trauth, H. A., Valyon, E., Brande Van Den, Van Noord, J. A., Vaquer, J. V., Hernandez Hector, H. V., Vereecken, G., Verkindre, C., Vigh, M., Viljoen, J. J., Vincken, W., Vinkler, I., Visser, S., Volgmann, L., Vorderstrasse, W., Voves, R., Vrancken, F., Weber, H. H., Wielders, P. L., Willoughby, P., Wurtz, J., Yang, W., Zabaleta, M., Zachgo, W., Zanini, A., Zeiner, M., Michael, H., Janistyn, W., Abdulla, R., Terzano, C., Fabbri, L., Barbaro, M. P., Izquierdo, J. L., Ramos, Pde L., and Harper, Ochoa

Subjects
Chronic bronchitis, medicine.drug_class, glucocorticosteroids, Placebo, exacerbations, Bronchodilator, medicine, COPD, humans, Roflumilast, Intention-to-treat analysis, business.industry, Body weight, chronic bronchitis, emphysema, inflammation, lung function, phosphodiesterase 4 inhibitor, PDE4, General Medicine, Tiotropium bromide, medicine.disease, respiratory tract diseases, Anesthesia, Salmeterol, business, medicine.drug
Abstract

Summary Background Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of the phosphodiesterase-4 inhibitor roflumilast have been investigated in studies of patients with moderate-to-severe COPD, but not in those concomitantly treated with longacting inhaled bronchodilators. The effect of roflumilast on lung function in patients with COPD that is moderate to severe who are already being treated with salmeterol or tiotropium was investigated. Methods In two double-blind, multicentre studies done in an outpatient setting, after a 4-week run-in, patients older than 40 years with moderate-to-severe COPD were randomly assigned to oral roflumilast 500 μg or placebo once a day for 24 weeks, in addition to salmeterol (M2-127 study) or tiotropium (M2-128 study). The primary endpoint was change in prebronchodilator forced expiratory volume in 1 s (FEV 1 ). Analysis was by intention to treat. The studies are registered with ClinicalTrials.gov, number NCT00313209 for M2-127, and NCT00424268 for M2-128. Findings In the salmeterol plus roflumilast trial, 466 patients were assigned to and treated with roflumilast and 467 with placebo; in the tiotropium plus roflumilast trial, 371 patients were assigned to and treated with roflumilast and 372 with placebo. Compared with placebo, roflumilast consistently improved mean prebronchodilator FEV 1 by 49 mL (p 1 was noted in both groups. Furthermore, roflumilast had beneficial effects on other lung function measurements and on selected patient-reported outcomes in both groups. Nausea, diarrhoea, weight loss, and, to a lesser extent, headache were more frequent in patients in the roflumilast groups. These adverse events were associated with increased patient withdrawal. Interpretation Roflumilast improves lung function in patients with COPD treated with salmeterol or tiotropium, and could become an important treatment for these patients. Funding Nycomed.

Published
2009
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37. Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial

Author

van Tinteren, Harm, Hoekstra, Otto S, Smit, Egbert F, van den Bergh, Jan H A M, Schreurs, Ad J M, Stallaert, Roland A L M, van Velthoven, Piet C M, Comans, Emile F I, Diepenhorst, Fred W, Verboom, Paul, van Mourik, Johan C, Postmus, Pieter E, Boers, Maarten, and Teule, Gerrit J J

Subjects
Lung cancer, Non-small cell -- Diagnosis, PET imaging, Thoracotomy
Published
2002

38. On-demand relief treatment for asthma

Author

Tattersfield, A E, Ekstrom, T, Rasidakis, A, Schreurs, A J M, Eivindson, A, Potma, D S, Lofdahl, C-G, Badrinath, P, Joseph, J, Fowler, Stephen, Currie, Graeme, and Lipworth, Brian J

Subjects
Asthma -- Drug therapy, Formoterol -- Evaluation, Terbutaline -- Evaluation, Corticosteroids -- Health aspects, Bronchodilator agents -- Health aspects
Published
2001

39. Bronchoscopic therapy in patients with intraluminal typical bronchial carcinoid

Author

Sutedja, Tom G., Schreurs, Ad J., Vanderschueren, Roland G., Kwa, Bibi, Werf, Tjip S. vd, and Postmus, Pieter E.

Subjects
Lung tumors -- Care and treatment, Carcinoid -- Care and treatment, Bronchoscopy -- Health aspects, Health, Care and treatment, Health aspects
Abstract

Objective: To study the efficacy of bronchoscopic therapy in patients with intraluminal typical bronchial carcinoid. Design: Retrospective analysis of the data of patients with bronchial carcinoid, treated primarily with bronchoscopic [...]

Published
1995

42. A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

Author

Sub Experimental pharmacology, Pharmacology, Nieskens, Tom T G, Peters, Janny G P, Schreurs, Marieke J, Smits, Niels, Woestenenk, Rob, Jansen, Katja, van der Made, Thom K, Röring, Melanie, Hilgendorf, Constanze, Wilmer, Martijn J, Masereeuw, Roos, Sub Experimental pharmacology, Pharmacology, Nieskens, Tom T G, Peters, Janny G P, Schreurs, Marieke J, Smits, Niels, Woestenenk, Rob, Jansen, Katja, van der Made, Thom K, Röring, Melanie, Hilgendorf, Constanze, Wilmer, Martijn J, and Masereeuw, Roos

Published
2016

46. Fourth European Workshop on Inflammation Wilrijk March 1982

Author

Hartung, H. P., Bitter-Suermann, D., Hadding, U., Maillet, F., Lambré, C., Kazatchkine, M., Kalter, E. S., van Dijk, W. C., Timmermans, A., Verhoef, J., Bouma, B. N., Doekes, G., Daha, M. R., van Es, L. A., Drummond, L., Gemmell, D. K., Rampart, M., Bult, H., Herman, A. G., Gemsa, D., Fischer, E., Jouvin, M. H., Hartwig, H. P., Parnham, M. J., Winkelmann, J., Pelletier, M., Giroud, J. P., Schreurs, A. J. M., Nijkamp, F. P., Ouwendijk, R. J. T., Zijlstra, F. J., Wilson, J. H. P., Bonta, I. L., Vincent, J. E., Thomas, L. L. M., Büller, H. R., Sturk, A., Joop, K., Cate, J. W. ten, Henricks, P., Page, C. P., Paul, W., Elliott, G. R., Adolfs, M. J. P., Rainsford, K. D., Willis, C. M., Robins, P. G., Munthe, E., Fagerhol, M., Willard, K., Jellum, E., Fontaine, J., Herchuelz, A., Famaey, J. P., Leyck, S., Etschenberg, E., Elferink, J. G. R., Riemersma, J. C., Morley, J., Cate, H. ten, Henricks, P. A., Nijkamp, F., Junien, J. L., Guillaume, M., Lakatos, C., Karran, E. H., Green, A. P., Mangan, F. R., Payne, T., Dewald, B., Siegl, H., Gubler, H. U., Ott, H., Baggiolini, M., Conti, P., Continenza, M. A., Cifone, M. G., Alesse, E., Ianni, G., Angeletti, P. U., Stolz, E., Reuse, J., Camussi G., Montrocchio G., Antro C., Tetta C., Bussolino F., Emanuelli G., Mehler, E. L., Habicht, J., Brune, K., Van Gossum, A., Cremer, M., Delronche, M., Appelboom, T., Pierart, M., Görtz, R., Deby, C., Deby-Dupont, G., Boogaerts, M. A., Vermylen, J., Deckmyn, H., Moldow, C. F., Verwilghen, R., Schrauwen, E., Weyns, A., Gillebert, Ch., Houvenaghel, A., Wickens, D. G., Dormandy, T. L., and Laekeman, G. M.

Published
1982
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50. Hypothermia and acute alcohol intoxication in Dutch adolescents: The relationship between core and outdoor temperatures.

Author

Schreurs, Claire J., Van Hoof, Joris J., and Van Der Lely, Nico

Subjects
BODY temperature, CHI-squared test, STATISTICAL correlation, FISHER exact test, HYPOTHERMIA, QUESTIONNAIRES, T-test (Statistics), TEMPERATURE, DATA analysis software, ALCOHOLIC intoxication, MANN Whitney U Test, ONE-way analysis of variance
Abstract

Purpose: To investigate hypothermia and its potential association with core and outdoor temperatures in adolescents suffering from acute alcohol intoxication.Methods: Data were derived from the Dutch Pediatric Surveillance System, which monitors alcohol intoxication among all Dutch adolescents. Adolescents < 18 years of age with a positive blood alcohol concentration (BAC > 0 g/l) were included. This resulted in an analysis of data from the years 2011 to 2015 that were obtained through a total of 967 questionnaires.Results: This study revealed small but significantly lower core temperatures in winter time (35.59°C [96.06°F]) versus summer time (35.83°C [96.49°F]). These differences could not be attributed to the genders and ages of the patients. In winter time, 26.6% of the adolescents experienced mild hypothermia, with body temperatures of 32.00–34.99°C (89.60–94.98°F), compared to 18.0% during the summer. Although not significant, amounts of time spent in reduced consciousness, hospitalized and receiving intensive care were prolonged in adolescents with lower core temperatures.Conclusions: This article is the first to describe this trend of hypothermia among alcohol-intoxicated Dutch adolescents admitted during winter time. These findings are important for awareness of this issue and can be used for prevention strategies in the future. [ABSTRACT FROM AUTHOR]

Published
2017
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