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1. Author Correction: A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

Author

Ryl, Tatsiana, Afanasyeva, Elena, Hartmann, Till, Schwermer, Melanie, Schneider, Markus, Schröder, Christopher, Wagemanns, Maren, Bister, Arthur, Kanber, Deniz, Steenpass, Laura, Schramm, Kathrin, Jones, Barbara, Jones, David T. W., Biewald, Eva, Astrahantseff, Kathy, Hanenberg, Helmut, Rahmann, Sven, Lohmann, Dietmar R., Schramm, Alexander, and Ketteler, Petra

Published
2024
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2. A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma

Author

Ryl, Tatsiana, Afanasyeva, Elena, Hartmann, Till, Schwermer, Melanie, Schneider, Markus, Schröder, Christopher, Wagemanns, Maren, Bister, Arthur, Kanber, Deniz, Steenpass, Laura, Schramm, Kathrin, Jones, Barbara, Jones, David T. W., Biewald, Eva, Astrahantseff, Kathy, Hanenberg, Helmut, Rahmann, Sven, Lohmann, Dietmar R., Schramm, Alexander, and Ketteler, Petra

Published
2024
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3. Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Author

Keck, Michaela-Kristina, Sill, Martin, Wittmann, Andrea, Joshi, Piyush, Stichel, Damian, Beck, Pengbo, Okonechnikow, Konstantin, Sievers, Philipp, Wefers, Annika K, Roncaroli, Federico, Avula, Shivaram, McCabe, Martin G, Hayden, James T, Wesseling, Pieter, Øra, Ingrid, Nistér, Monica, Kranendonk, Mariëtte EG, Tops, Bastiaan BJ, Zapotocky, Michal, Zamecnik, Josef, Vasiljevic, Alexandre, Fenouil, Tanguy, Meyronet, David, von Hoff, Katja, Schüller, Ulrich, Loiseau, Hugues, Figarella-Branger, Dominique, Kramm, Christof M, Sturm, Dominik, Scheie, David, Rauramaa, Tuomas, Pesola, Jouni, Gojo, Johannes, Haberler, Christine, Brandner, Sebastian, Jacques, Tom, Sexton Oates, Alexandra, Saffery, Richard, Koscielniak, Ewa, Baker, Suzanne J, Yip, Stephen, Snuderl, Matija, Ud Din, Nasir, Samuel, David, Schramm, Kathrin, Blattner-Johnson, Mirjam, Selt, Florian, Ecker, Jonas, Milde, Till, von Deimling, Andreas, Korshunov, Andrey, Perry, Arie, Pfister, Stefan M, Sahm, Felix, Solomon, David A, and Jones, David TW

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric, Genetics, Rare Diseases, Pediatric Cancer, Cancer, Pediatric Research Initiative, Neurosciences, Brain Cancer, Brain Disorders, Child, Child, Preschool, Female, Humans, Infant, Male, Cell Cycle Proteins, Central Nervous System Neoplasms, DNA Methylation, DNA-Binding Proteins, Neuroectodermal Tumors, Primitive, RNA-Binding Proteins, Transcription Factors, Tumor Suppressor Proteins, Wnt Signaling Pathway, PLAGL1, PLAGL2, Molecular neuro-oncology, Pediatric cancer, Clinical Sciences, Neurology & Neurosurgery
Abstract

Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0-14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well as a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification in combination with copy number, RNA-seq, and ChIP-seq analysis to characterize a newly identified CNS tumor type. In addition, we report histology, patient characteristics, and survival data in this tumor type. We describe a biologically distinct pediatric CNS tumor type (n = 31 cases) that is characterized by focal high-level amplification and resultant overexpression of either PLAGL1 or PLAGL2, and an absence of recurrent genetic alterations characteristic of other pediatric CNS tumor types. Both genes act as transcription factors for a regulatory subset of imprinted genes (IGs), components of the Wnt/β-Catenin pathway, and the potential drug targets RET and CYP2W1, which are also specifically overexpressed in this tumor type. A derived PLAGL-specific gene expression signature indicates dysregulation of imprinting control and differentiation/development. These tumors occurred throughout the neuroaxis including the cerebral hemispheres, cerebellum, and brainstem, and were predominantly composed of primitive embryonal-like cells lacking robust expression of markers of glial or neuronal differentiation (e.g., GFAP, OLIG2, and synaptophysin). Tumors with PLAGL1 amplification were typically diagnosed during adolescence (median age 10.5 years), whereas those with PLAGL2 amplification were diagnosed during early childhood (median age 2 years). The 10-year overall survival was 66% for PLAGL1-amplified tumors, 25% for PLAGL2-amplified tumors, 18% for male patients, and 82% for female patients. In summary, we describe a new type of biologically distinct CNS tumor characterized by PLAGL1/2 amplification that occurs predominantly in infants and toddlers (PLAGL2) or adolescents (PLAGL1) which we consider best classified as a CNS embryonal tumor and which is associated with intermediate survival. The cell of origin and optimal treatment strategies remain to be defined.

Published
2023

4. Genomic ALK alterations in primary and relapsed neuroblastoma

Author

Rosswog, Carolina, Fassunke, Jana, Ernst, Angela, Schömig-Markiefka, Birgid, Merkelbach-Bruse, Sabine, Bartenhagen, Christoph, Cartolano, Maria, Ackermann, Sandra, Theissen, Jessica, Blattner-Johnson, Mirjam, Jones, Barbara, Schramm, Kathrin, Altmüller, Janine, Nürnberg, Peter, Ortmann, Monika, Berthold, Frank, Peifer, Martin, Büttner, Reinhard, Westermann, Frank, Schulte, Johannes H., Simon, Thorsten, Hero, Barbara, and Fischer, Matthias

Published
2023
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5. Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Author

Keck, Michaela-Kristina, Sill, Martin, Wittmann, Andrea, Joshi, Piyush, Stichel, Damian, Beck, Pengbo, Okonechnikow, Konstantin, Sievers, Philipp, Wefers, Annika K., Roncaroli, Federico, Avula, Shivaram, McCabe, Martin G., Hayden, James T., Wesseling, Pieter, Øra, Ingrid, Nistér, Monica, Kranendonk, Mariëtte E. G., Tops, Bastiaan B. J., Zapotocky, Michal, Zamecnik, Josef, Vasiljevic, Alexandre, Fenouil, Tanguy, Meyronet, David, von Hoff, Katja, Schüller, Ulrich, Loiseau, Hugues, Figarella-Branger, Dominique, Kramm, Christof M., Sturm, Dominik, Scheie, David, Rauramaa, Tuomas, Pesola, Jouni, Gojo, Johannes, Haberler, Christine, Brandner, Sebastian, Jacques, Tom, Sexton Oates, Alexandra, Saffery, Richard, Koscielniak, Ewa, Baker, Suzanne J., Yip, Stephen, Snuderl, Matija, Ud Din, Nasir, Samuel, David, Schramm, Kathrin, Blattner-Johnson, Mirjam, Selt, Florian, Ecker, Jonas, Milde, Till, von Deimling, Andreas, Korshunov, Andrey, Perry, Arie, Pfister, Stefan M., Sahm, Felix, Solomon, David A., and Jones, David T. W.

Published
2023
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6. Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Author

Peterziel, Heike, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F., Herter, Sonja, Fiesel, Petra, Berker, Yannick, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C., Reuss, David, Turunen, Laura, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U., Gojo, Johannes, Hutter, Caroline, Øra, Ingrid, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert, Nathrath, Michaela, Sparber-Sauer, Monika, Sehested, Astrid, Kramm, Christof M., Dirksen, Uta, Kallioniemi, Olli, Pfister, Stefan M., van Tilburg, Cornelis M., Jones, David T. W., Saarela, Jani, Pietiäinen, Vilja, Jäger, Natalie, Schlesner, Matthias, Kopp-Schneider, Annette, Oppermann, Sina, Milde, Till, Witt, Olaf, and Oehme, Ina

Published
2022
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7. Gene regulatory network landscape of Group 3/4 medulloblastoma

Author

Joshi, Piyush, primary, Stelzer, Tamina, additional, Okonechnikov, Konstantin, additional, Sarropoulos, Ioannis, additional, Sepp, Mari, additional, Pour-Jamnani, Mischan V., additional, Rademacher, Anne, additional, Yamada-Saito, Tetsuya, additional, Schneider, Céline, additional, Schmidt, Julia, additional, Schäfer, Philipp, additional, Leiss, Kevin, additional, Bortolomeazzi, Michele, additional, Mallm, Jan-Philipp, additional, da Silva, Patricia B.G., additional, Statz, Britta, additional, Wittmann, Andrea, additional, Schramm, Kathrin, additional, Blattner-Johnson, Mirjam, additional, Fiesel, Petra, additional, Jones, Barbara, additional, Milde, Till, additional, Pajtler, Kristian, additional, van Tilburg, Cornelis M., additional, Witt, Olaf, additional, Rippe, Karsten, additional, Korshunov, Andrey, additional, Jones, David T.W., additional, Hovestadt, Volker, additional, Northcott, Paul A., additional, Thongjuea, Supat, additional, Jäger, Natalie, additional, Kaessmann, Henrik, additional, Pfister, Stefan M., additional, and Kutscher, Lena M., additional

Published
2024
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10. Outcome of Children and Adolescents With Relapsed/Refractory/Progressive Malignancies Treated With Molecularly Informed Targeted Drugs in the Pediatric Precision Oncology Registry INFORM

Author

Heipertz, Anna-Elisa, primary, Pajtler, Kristian W., additional, Pfaff, Elke, additional, Schramm, Kathrin, additional, Blattner-Johnson, Mirjam, additional, Milde, Till, additional, Jones, Barbara C., additional, Zuliani, Cecilia, additional, Hutter, Caroline, additional, Lohi, Olli, additional, Kattamis, Antonis, additional, Dachowska-Kalwak, Iwona, additional, Nilsson, Anna, additional, Gerber, Nicolas U., additional, Langenberg, Karin P.S., additional, Goemans, Bianca F., additional, Zwaan, C. Michel, additional, Molenaar, Jan J., additional, Jäger, Natalie, additional, Dirksen, Uta, additional, Witt, Ruth, additional, Pfister, Stefan M., additional, Jones, David T.W., additional, Kopp-Schneider, Annette, additional, Witt, Olaf, additional, and van Tilburg, Cornelis M., additional

Published
2023
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11. Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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12. Data from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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13. Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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14. Outcome of Children and Adolescents With Relapsed/Refractory/Progressive Malignancies Treated With Molecularly Informed Targeted Drugs in the Pediatric Precision Oncology Registry INFORM

Author

Afd Pharmaceutics, Pharmaceutics, Heipertz, Anna-Elisa, Pajtler, Kristian W, Pfaff, Elke, Schramm, Kathrin, Blattner-Johnson, Mirjam, Milde, Till, Jones, Barbara C, Zuliani, Cecilia, Hutter, Caroline, Lohi, Olli, Kattamis, Antonis, Dachowska-Kalwak, Iwona, Nilsson, Anna, Gerber, Nicolas U, Langenberg, Karin P S, Goemans, Bianca, Zwaan, C Michel, Molenaar, Jan J, Jäger, Natalie, Dirksen, Uta, Witt, Ruth, Pfister, Stefan M, Jones, David T W, Kopp-Schneider, Annette, Witt, Olaf, van Tilburg, Cornelis M, Afd Pharmaceutics, Pharmaceutics, Heipertz, Anna-Elisa, Pajtler, Kristian W, Pfaff, Elke, Schramm, Kathrin, Blattner-Johnson, Mirjam, Milde, Till, Jones, Barbara C, Zuliani, Cecilia, Hutter, Caroline, Lohi, Olli, Kattamis, Antonis, Dachowska-Kalwak, Iwona, Nilsson, Anna, Gerber, Nicolas U, Langenberg, Karin P S, Goemans, Bianca, Zwaan, C Michel, Molenaar, Jan J, Jäger, Natalie, Dirksen, Uta, Witt, Ruth, Pfister, Stefan M, Jones, David T W, Kopp-Schneider, Annette, Witt, Olaf, and van Tilburg, Cornelis M

Published
2023

15. Correction to: Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification (Acta Neuropathologica, (2023), 145, 1, (49-69), 10.1007/s00401-022-02516-2)

Author

Keck, Michaela-Kristina, Sill, Martin, Wittmann, Andrea, Joshi, Piyush, Stichel, Damian, Beck, Pengbo, Okonechnikow, Konstantin, Sievers, Philipp, Wefers, Annika K, Roncaroli, Federico, Avula, Shivaram, McCabe, Martin G, Hayden, James T, Wesseling, Pieter, Øra, Ingrid, Nistér, Monica, Kranendonk, Mariëtte E G, Tops, Bastiaan B J, Zapotocky, Michal, Zamecnik, Josef, Vasiljevic, Alexandre, Fenouil, Tanguy, Meyronet, David, von Hoff, Katja, Schüller, Ulrich, Loiseau, Hugues, Figarella-Branger, Dominique, Kramm, Christof M, Sturm, Dominik, Scheie, David, Rauramaa, Tuomas, Pesola, Jouni, Gojo, Johannes, Haberler, Christine, Brandner, Sebastian, Jacques, Tom, Sexton Oates, Alexandra, Saffery, Richard, Koscielniak, Ewa, Baker, Suzanne J, Yip, Stephen, Snuderl, Matija, Ud Din, Nasir, Samuel, David, Schramm, Kathrin, Blattner-Johnson, Mirjam, Selt, Florian, Ecker, Jonas, Milde, Till, von Deimling, Andreas, Korshunov, Andrey, Perry, Arie, Pfister, Stefan M, Sahm, Felix, and Solomon, David A

Subjects
Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc
Abstract

In the original publication, incorrect version of Fig. 6 was published and the correct version (Fig. 6) is given below. The original article has been corrected.

Published
2023

16. Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification

Author

Keck, Michaela-Kristina, primary, Sill, Martin, additional, Wittmann, Andrea, additional, Joshi, Piyush, additional, Stichel, Damian, additional, Beck, Pengbo, additional, Okonechnikow, Konstantin, additional, Sievers, Philipp, additional, Wefers, Annika K., additional, Roncaroli, Federico, additional, Avula, Shivaram, additional, McCabe, Martin G., additional, Hayden, James T., additional, Wesseling, Pieter, additional, Øra, Ingrid, additional, Nistér, Monica, additional, Kranendonk, Mariëtte E. G., additional, Tops, Bastiaan B. J., additional, Zapotocky, Michal, additional, Zamecnik, Josef, additional, Vasiljevic, Alexandre, additional, Fenouil, Tanguy, additional, Meyronet, David, additional, von Hoff, Katja, additional, Schüller, Ulrich, additional, Loiseau, Hugues, additional, Figarella-Branger, Dominique, additional, Kramm, Christof M., additional, Sturm, Dominik, additional, Scheie, David, additional, Rauramaa, Tuomas, additional, Pesola, Jouni, additional, Gojo, Johannes, additional, Haberler, Christine, additional, Brandner, Sebastian, additional, Jacques, Tom, additional, Sexton Oates, Alexandra, additional, Saffery, Richard, additional, Koscielniak, Ewa, additional, Baker, Suzanne J., additional, Yip, Stephen, additional, Snuderl, Matija, additional, Ud Din, Nasir, additional, Samuel, David, additional, Schramm, Kathrin, additional, Blattner-Johnson, Mirjam, additional, Selt, Florian, additional, Ecker, Jonas, additional, Milde, Till, additional, von Deimling, Andreas, additional, Korshunov, Andrey, additional, Perry, Arie, additional, Pfister, Stefan M., additional, Sahm, Felix, additional, Solomon, David A., additional, and Jones, David T. W., additional

Published
2022
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20. HGG-61.Landscape of cancer predisposition in pediatric high-grade glioma

Author

Blattner-Johnson, Mirjam, primary, Sturm, Dominik, additional, Sievers, Philipp, additional, Jones, Barbara, additional, Schramm, Kathrin, additional, Balasubramanian, Gnana Prakash, additional, Sill, Martin, additional, Jäger, Natalie, additional, van Tilburg, Cornelis M, additional, Milde, Till, additional, Pajtler, Kristian W, additional, Dikow, Nicola, additional, Hirsch, Steffen, additional, Sutter, Christian, additional, Sahm, Felix, additional, Witt, Olaf, additional, Pfister, Stefan M, additional, and Jones, David T W, additional

Published
2022
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21. Genomic Evolution and Personalized Therapy of an Infantile Fibrosarcoma Harboring anNTRKOncogenic Fusion

Author

Thorwarth, Anne, primary, Haase, Kerstin, additional, Röefzaad, Claudia, additional, Pajtler, Kristian W., additional, Schramm, Kathrin, additional, Hauptmann, Kathrin, additional, Behnke, Anke, additional, Vokuhl, Christian, additional, Elgeti, Thomas, additional, Gratopp, Alexander, additional, Schulte, Johannes H., additional, Scheer, Monika, additional, Hernáiz Driever, Pablo, additional, Nysom, Karsten, additional, Eggert, Angelika, additional, Henssen, Anton G., additional, and Deubzer, Hedwig E., additional

Published
2022
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22. Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Author

Peterziel, Heike; https://orcid.org/0000-0001-9261-7144, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F, Herter, Sonja, Fiesel, Petra, Berker, Yannick; https://orcid.org/0000-0002-6707-0834, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C, Reuss, David, Turunen, Laura; https://orcid.org/0000-0003-0274-4794, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin; https://orcid.org/0000-0001-7616-7665, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U; https://orcid.org/0000-0002-1783-631X, Gojo, Johannes, Hutter, Caroline; https://orcid.org/0000-0003-2059-4814, Øra, Ingrid; https://orcid.org/0000-0002-3931-4125, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert; https://orcid.org/0000-0002-2248-323X, Nathrath, Michaela, Sparber-Sauer, Monika; https://orcid.org/0000-0001-9551-2399, et al, Peterziel, Heike; https://orcid.org/0000-0001-9261-7144, Jamaladdin, Nora, ElHarouni, Dina, Gerloff, Xenia F, Herter, Sonja, Fiesel, Petra, Berker, Yannick; https://orcid.org/0000-0002-6707-0834, Blattner-Johnson, Mirjam, Schramm, Kathrin, Jones, Barbara C, Reuss, David, Turunen, Laura; https://orcid.org/0000-0003-0274-4794, Friedenauer, Aileen, Holland-Letz, Tim, Sill, Martin; https://orcid.org/0000-0001-7616-7665, Weiser, Lena, Previti, Christopher, Balasubramanian, Gnanaprakash, Gerber, Nicolas U; https://orcid.org/0000-0002-1783-631X, Gojo, Johannes, Hutter, Caroline; https://orcid.org/0000-0003-2059-4814, Øra, Ingrid; https://orcid.org/0000-0002-3931-4125, Lohi, Olli, Kattamis, Antonis, de Wilde, Bram, Westermann, Frank, Tippelt, Stephan, Graf, Norbert; https://orcid.org/0000-0002-2248-323X, Nathrath, Michaela, Sparber-Sauer, Monika; https://orcid.org/0000-0001-9551-2399, and et al

Abstract

The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75-78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. In 89 cases (67%), sufficient viable tissue was received; 69 (78%) passed internal quality controls. The DSP results matched the identified molecular targets, including BRAF, ALK, MET, and TP53 status. Drug vulnerabilities were identified in 80% of cases lacking actionable (very) high-evidence molecular events, adding value to the molecular data. Striking parallels between clinical courses and the DSP results were observed in selected patients. Overall, DSP in clinical real-time is feasible in international multicenter precision oncology programs.

Published
2022

24. Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models

Author

Gatzweiler, Charlotte, primary, Ridinger, Johannes, additional, Herter, Sonja, additional, Gerloff, Xenia F., additional, ElHarouni, Dina, additional, Berker, Yannick, additional, Imle, Roland, additional, Schmitt, Lukas, additional, Kreth, Sina, additional, Stainczyk, Sabine, additional, Ayhan, Simay, additional, Najafi, Sara, additional, Krunic, Damir, additional, Frese, Karen, additional, Meder, Benjamin, additional, Reuss, David, additional, Fiesel, Petra, additional, Schramm, Kathrin, additional, Blattner-Johnson, Mirjam, additional, Jones, David T. W., additional, Banito, Ana, additional, Westermann, Frank, additional, Oppermann, Sina, additional, Milde, Till, additional, Peterziel, Heike, additional, Witt, Olaf, additional, and Oehme, Ina, additional

Published
2022
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25. Secondary Biphenotypic Acute Leukemia Following Rosai-Dorfman-Disease A Coincidence?

Author

Thieme, Anne, additional, Maurus, Katja, additional, Ernestus, Karen, additional, Hirsch, Steffen, additional, Schramm, Kathrin, additional, Wirth, Clemens, additional, Buck, Andreas, additional, Härtel, Christoph, additional, Schlegel, Paul G., additional, Eyrich, Matthias, additional, Woelfl, Mathias, additional, Classen, Carl Friedrich, additional, and Wiegering, Verena A., additional

Published
2021
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27. Secondary biphenotypic leukemia following Rosai-Dorfman-Disease A coincidence?

Author

Thieme, Anne, primary, Maurus, Katja, additional, Ernestus, Karen, additional, Hirsch, Steffen, additional, Schramm, Kathrin, additional, Benoit, Clemens, additional, Buck, Andreas, additional, Haertel, Christoph, additional, Schlegel, Paul, additional, Eyrich, Matthias, additional, Wölfl, Matthias, additional, Classen, Carl-Friedrich, additional, and Wiegering, Verena, additional

Published
2021
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28. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, additional, Pajtler, Kristian W., additional, Langenberg, Karin P.S., additional, Fiesel, Petra, additional, Jones, Barbara C., additional, Balasubramanian, Gnana Prakash, additional, Stark, Sebastian, additional, Johann, Pascal D., additional, Blattner-Johnson, Mirjam, additional, Schramm, Kathrin, additional, Dikow, Nicola, additional, Hirsch, Steffen, additional, Sutter, Christian, additional, Grund, Kerstin, additional, von Stackelberg, Arend, additional, Kulozik, Andreas E., additional, Lissat, Andrej, additional, Borkhardt, Arndt, additional, Meisel, Roland, additional, Reinhardt, Dirk, additional, Klusmann, Jan-Henning, additional, Fleischhack, Gudrun, additional, Tippelt, Stephan, additional, von Schweinitz, Dietrich, additional, Schmid, Irene, additional, Kramm, Christof M., additional, von Bueren, André O., additional, Calaminus, Gabriele, additional, Vorwerk, Peter, additional, Graf, Norbert, additional, Westermann, Frank, additional, Fischer, Matthias, additional, Eggert, Angelika, additional, Burkhardt, Birgit, additional, Wößmann, Wilhelm, additional, Nathrath, Michaela, additional, Hecker-Nolting, Stefanie, additional, Frühwald, Michael C., additional, Schneider, Dominik T., additional, Brecht, Ines B., additional, Ketteler, Petra, additional, Fulda, Simone, additional, Koscielniak, Ewa, additional, Meister, Michael T., additional, Scheer, Monika, additional, Hettmer, Simone, additional, Schwab, Matthias, additional, Tremmel, Roman, additional, Øra, Ingrid, additional, Hutter, Caroline, additional, Gerber, Nicolas U., additional, Lohi, Olli, additional, Kazanowska, Bernarda, additional, Kattamis, Antonis, additional, Filippidou, Maria, additional, Goemans, Bianca, additional, Zwaan, C. Michel, additional, Milde, Till, additional, Jäger, Natalie, additional, Wolf, Stephan, additional, Reuss, David, additional, Sahm, Felix, additional, von Deimling, Andreas, additional, Dirksen, Uta, additional, Freitag, Angelika, additional, Witt, Ruth, additional, Lichter, Peter, additional, Kopp-Schneider, Annette, additional, Jones, David T.W., additional, Molenaar, Jan J., additional, Capper, David, additional, Pfister, Stefan M., additional, and Witt, Olaf, additional

Published
2021
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29. The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P. S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E., Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M., von Bueren, Andre O., Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Woessmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Fruehwald, Michael C., Schneider, Dominik T., Brecht, Ines B., Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T., Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Ora, Ingrid, Hutter, Caroline, Gerber, Nicolas U., Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C. Michel, Milde, Till, Jaeger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T. W., Molenaar, Jan J., Capper, David, Pfister, Stefan M., Witt, Olaf, van Tilburg, Cornelis M., Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P. S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, von Stackelberg, Arend, Kulozik, Andreas E., Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M., von Bueren, Andre O., Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Woessmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Fruehwald, Michael C., Schneider, Dominik T., Brecht, Ines B., Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T., Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Ora, Ingrid, Hutter, Caroline, Gerber, Nicolas U., Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C. Michel, Milde, Till, Jaeger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T. W., Molenaar, Jan J., Capper, David, Pfister, Stefan M., and Witt, Olaf

Abstract

INFORM is a prospective, multinational registry gathering clinical and molecular data of relapsed, progressive, or high-risk pediatric patients with cancer. This report describes long-term follow-up of 519 patients in whom molecular alterations were evaluated according to a predefined seven-scale target prioritization algorithm. Mean turnaround time from sample receipt to report was 25.4 days. The highest target priority level was observed in 42 patients (8.1%). Of these, 20 patients received matched targeted treatment with a median progression-free survival of 204 days [95% confidence interval (CI), 99-not applicable], compared with 117 days (95% CI, 106-143; P = 0.011) in all other patients. The respective molecular targets were shown to be predictive for matched treatment response and not prognostic surrogates for improved outcome. Hereditary cancer predisposition syndromes were identified in 7.5% of patients, half of which were newly identified through the study. Integrated molecular analyses resulted in a change or refinement of diagnoses in 8.2% of cases. SIGNIFICANCE: The pediatric precision oncology INFORM registry prospectively tested a target prioritization algorithm in a real-world, multinational setting and identified subgroups of patients benefiting from matched targeted treatment with improved progression-free survival, refinement of diagnosis, and identification of hereditary cancer predisposition syndromes.

Published
2021

30. The pediatric precision oncology inform registry:Clinical outcome and benefit for patients with very high-evidence targets

Author

Van Tilburg, Cornelis M., Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P.S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, Von Stackelberg, Arend, Kulozik, Andreas E., Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan Henning, Fleischhack, Gudrun, Tippelt, Stephan, Von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M., Von Bueren, André O., Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Frühwald, Michael C., Schneider, Dominik T., Brecht, Ines B., Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T., Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Øra, Ingrid, Hutter, Caroline, Gerber, Nicolas U., Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C. Michel, Milde, Till, Jäger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, Von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T.W., Molenaar, Jan J., Capper, David, Pfister, Stefan M., Witt, Olaf, Van Tilburg, Cornelis M., Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P.S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Dikow, Nicola, Hirsch, Steffen, Sutter, Christian, Grund, Kerstin, Von Stackelberg, Arend, Kulozik, Andreas E., Lissat, Andrej, Borkhardt, Arndt, Meisel, Roland, Reinhardt, Dirk, Klusmann, Jan Henning, Fleischhack, Gudrun, Tippelt, Stephan, Von Schweinitz, Dietrich, Schmid, Irene, Kramm, Christof M., Von Bueren, André O., Calaminus, Gabriele, Vorwerk, Peter, Graf, Norbert, Westermann, Frank, Fischer, Matthias, Eggert, Angelika, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Hecker-Nolting, Stefanie, Frühwald, Michael C., Schneider, Dominik T., Brecht, Ines B., Ketteler, Petra, Fulda, Simone, Koscielniak, Ewa, Meister, Michael T., Scheer, Monika, Hettmer, Simone, Schwab, Matthias, Tremmel, Roman, Øra, Ingrid, Hutter, Caroline, Gerber, Nicolas U., Lohi, Olli, Kazanowska, Bernarda, Kattamis, Antonis, Filippidou, Maria, Goemans, Bianca, Zwaan, C. Michel, Milde, Till, Jäger, Natalie, Wolf, Stephan, Reuss, David, Sahm, Felix, Von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Kopp-Schneider, Annette, Jones, David T.W., Molenaar, Jan J., Capper, David, Pfister, Stefan M., and Witt, Olaf

Abstract

INFORM is a prospective, multinational registry gathering clinical and molecular data of relapsed, progressive, or high-risk pediatric patients with cancer. This report describes long-term follow-up of 519 patients in whom molecular alterations were evaluated according to a predefined seven-scale target prioritization algorithm. Mean turnaround time from sample receipt to report was 25.4 days. The highest target priority level was observed in 42 patients (8.1%). Of these, 20 patients received matched targeted treatment with a median progression-free survival of 204 days [95% confidence interval (CI), 99–not applicable], compared with 117 days (95% CI, 106–143; P = 0.011) in all other patients. The respective molecular targets were shown to be predictive for matched treatment response and not prognostic surrogates for improved outcome. Hereditary cancer predisposition syndromes were identified in 7.5% of patients, half of which were newly identified through the study. Integrated molecular analyses resulted in a change or refinement of diagnoses in 8.2% of cases.

Published
2021

33. Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma

Author

Mayr, Lisa, primary, Guntner, Armin S., additional, Madlener, Sibylle, additional, Schmook, Maria T., additional, Peyrl, Andreas, additional, Azizi, Amedeo A., additional, Dieckmann, Karin, additional, Reisinger, Dominik, additional, Stepien, Natalia M., additional, Schramm, Kathrin, additional, Laemmerer, Anna, additional, Jones, David T. W., additional, Ecker, Jonas, additional, Sahm, Felix, additional, Milde, Till, additional, Pajtler, Kristian W., additional, Blattner-Johnson, Mirjam, additional, Strbac, Miroslav, additional, Dorfer, Christian, additional, Czech, Thomas, additional, Kirchhofer, Dominik, additional, Gabler, Lisa, additional, Berger, Walter, additional, Haberler, Christine, additional, Müllauer, Leonhard, additional, Buchberger, Wolfgang, additional, Slavc, Irene, additional, Lötsch-Gojo, Daniela, additional, and Gojo, Johannes, additional

Published
2020
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34. MODL-11. COMPARISON OF HUMAN & MURINE PA/PXA CHARACTERISTICS

Author

Sommerkamp, Alexander C, primary, Sun, Pengbo, additional, Wefers, Annika K, additional, Ismer, Britta, additional, Schramm, Kathrin, additional, Wittmann, Andrea, additional, Gronych, Jan, additional, Korshunov, Andrey, additional, von Deimling, Andreas, additional, Jäger, Natalie, additional, Pfister, Stefan M, additional, and Jones, David T W, additional

Published
2020
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36. The pediatric precision oncology study INFORM: Clinical outcome and benefit for molecular subgroups.

Author

van Tilburg, Cornelis Martinus, primary, Pfaff, Elke, additional, Pajtler, Kristian W., additional, Langenberg, Karin P.S., additional, Fiesel, Petra, additional, Jones, Barbara C., additional, Balasubramanian, Gnana Prakash, additional, Stark, Sebastian, additional, Johann, Pascal D., additional, Blattner-Johnson, Mirjam, additional, Schramm, Kathrin, additional, Jäger, Natalie, additional, von Deimling, Andreas, additional, Dirksen, Uta, additional, Freitag, Angelika, additional, Witt, Ruth, additional, Lichter, Peter, additional, Jones, David T.W., additional, Pfister, Stefan M., additional, and Witt, Olaf, additional

Published
2020
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38. DECIPHER pooled shRNA library screen identifies PP2A and FGFR signaling as potential therapeutic targets for diffuse intrinsic pontine gliomas

Author

Schramm, Kathrin, primary, Iskar, Murat, additional, Statz, Britta, additional, Jäger, Natalie, additional, Haag, Daniel, additional, Słabicki, Mikołaj, additional, Pfister, Stefan M, additional, Zapatka, Marc, additional, Gronych, Jan, additional, Jones, David T W, additional, and Lichter, Peter, additional

Published
2019
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39. „Raus mit der Sprache“: Aktuelle Bemühungen um eine strafprozessuale Reformierung des Zeugnisverweigerungsrechts für Handlungsfelder Sozialer Arbeit

Author

Schramm, Kathrin, Rudolph, Martin, Technische Universität Dresden, Beć, Ronald, Schramm, Kathrin, Rudolph, Martin, Technische Universität Dresden, and Beć, Ronald

Abstract

In der sozialpädagogischen Arbeit können Situationen entstehen, in denen Fachkräften vertrauliche Informationen zuteil werden, deren Schutz im Eigeninteresse der Adressat*innen oder des Staates liegen kann. Insbesondere die niedrigschwellige Arbeit mit Personen und Gruppen, die aus verschiedenen Gründen eine skeptische bis ablehnende Haltung gegenüber institutionellen Strukturen einnehmen – also mitunter auch Einrichtungen, für die Sozialarbeiter*innen tätig sind – oder mit Menschen, die beispielsweise aufgrund stoffgebundener Abhängigkeiten oder Verwicklungen in als extremistisch definierten Gruppen Strafverfolgung befürchten, erfordert von Sozialarbeiter*innen ein hohes Maß an Sensibilität für die eigene Rolle als Geheimnisträger nach § 203 Strafgesetzbuch (StGB). Gleiches gilt für Hilfesuchende, die sich an Opferberatungsstellen wenden und womöglich aus persönlichen Gründen ein Strafverfahren ablehnen, auch wenn sie selbst nicht beschuldigt wären. Die im Vertrauen von Adressat*innen erlangte Erkenntnis unterliegt zwar der Schweigepflicht, dies sichert den Sozialarbeiter*innen mit staatlicher Anerkennung im Strafverfahren allerdings kein Zeugnisverweigerungsrecht nach § 53 Strafprozessordnung (StPO) zu. Beides sind unterschiedliche rechtliche Regelungen, allerdings gibt es mit Ärzt*innen, Rechtsanwält*innen, Psycholog*innen, Journalist*innen, etc. Berufsgruppen, die in beiden Gesetzestexten berücksichtigt werden. Für Sozialarbeiter*innen gilt dieser Umstand nicht, ein Zeugnisverweigerungsrecht steht ihnen im Strafverfahren, mit Ausnahme von entsprechend qualifizierten Mitarbeiter*innen in Schwangerschaftsberatungsstellen sowie Beratungsstellen für Betäubungsmittelabhängige, nicht zu. Die vorliegende Masterarbeit beleuchtet die rechtliche und fachliche Aspekte des fehlenden Zeugnisverweigerungsrecht in der Sozialen Arbeit, die aktuellen Reformbemühungen aus Praxis und Wissenschaft sowie die Auswirkungen des fehlenden Zeugnisverweigerungsrechts auf die Praxis aus Si

Published
2018

40. LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA

Author

Buhl, Juliane L, primary, Selt, Florian, additional, Hielscher, Thomas, additional, Sahm, Felix, additional, Capper, David, additional, Schramm, Kathrin, additional, Ridinger, Johannes, additional, Usta, Diren, additional, Ecker, Jonas, additional, Oehme, Ina, additional, Tilburg, Cornelis M van, additional, Kool, Marcel, additional, von Deimling, Andreas, additional, Schuhmann, Martin U, additional, Korshunov, Andrey, additional, Pfister, Stefan M, additional, Brummer, Tilman, additional, Jones, David T W, additional, Witt, Olaf, additional, and Milde, Till, additional

Published
2018
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41. Recurrent MET fusion genes represent a drug target in pediatric glioblastoma

Author

Bender, Sebastian, Gronych, Jan, Warnatz, Hans-Jörg, Hutter, Barbara, Gröbner, Susanne, Ryzhova, Marina, Pfaff, Elke, Hovestadt, Volker, Weinberg, Florian, Halbach, Sebastian, Kool, Marcel, Northcott, Paul A, Sturm, Dominik, Bjerke, Lynn, Zichner, Thomas, Stütz, Adrian M, Schramm, Kathrin, Huang, Bingding, Buchhalter, Ivo, Heinold, Michael, Risch, Thomas, Worst, Barbara C, van Tilburg, Cornelis M, Weber, Ursula D, Zapatka, Marc, Raeder, Benjamin, Milford, David, Heiland, Sabine, von Kalle, Christof, Previti, Christopher, Lawerenz, Chris, Kulozik, Andreas E, Unterberg, Andreas, Witt, Olaf, von Deimling, Andreas, Capper, David, Truffaux, Nathalène, Grill, Jacques, Jabado, Nada, Sehested, Astrid M, Sumerauer, David, Brahim, Dorra Hmida-Ben, Trabelsi, Saoussen, Ng, Ho-Keung, Zagzag, David, Allen, Jeffrey C, Karajannis, Matthias A, Gottardo, Nicholas G, Jones, Chris, Korbel, Jan O, Schmidt, Sabine, Wolf, Stephan, Reifenberger, Guido, Felsberg, Jörg, Brors, Benedikt, Herold-Mende, Christel, Lehrach, Hans, Brummer, Tilman, Korshunov, Andrey, Eils, Roland, Yaspo, Marie-Laure, Pfister, Stefan M, Lichter, Peter, and Jones, David T W

Subjects
Pediatric tumors -- Genetic aspects -- Development and progression -- Drug therapy, Oncogenes -- Health aspects, Molecular targeted therapy -- Innovations, Glioblastomas -- Genetic aspects -- Development and progression -- Drug therapy, Biological sciences, Health
Abstract

Author(s): International Cancer Genome Consortium PedBrain Tumor Project; Sebastian Bender [1, 2, 3]; Jan Gronych [3, 4]; Hans-Jörg Warnatz [5]; Barbara Hutter [6]; Susanne Gröbner [1, 3]; Marina Ryzhova [7]; [...]

Published
2016
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43. PCM-15SOMATIC CRISPR/Cas9-MEDIATED TUMOR SUPPRESSOR DISRUPTION ENABLES VERSATILE BRAIN TUMOR MODELING

Author

Zuckermann, Marc, primary, Hovestadt, Volker, additional, Knobbe-Thomsen, Christiane B., additional, Zapatka, Marc, additional, Northcott, Paul A., additional, Schramm, Kathrin, additional, Belic, Jelena, additional, Jones, David T.W., additional, Tschida, Barbara, additional, Moriarity, Branden, additional, Largaespada, David, additional, Roussel, Martine F., additional, Korshunov, Andrey, additional, Reifenberger, Guido, additional, Pfister, Stefan M., additional, Lichter, Peter, additional, Kawauchi, Daisuke, additional, and Gronych, Jan, additional

Published
2016
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44. Abstract PR02: Somatic CRISPR/Cas9-mediated tumor suppressor disruption enables versatile brain tumor modeling

Author

Zuckermann, Marc, primary, Hovestadt, Volker, additional, Knobbe-Thomsen, Christiane B., additional, Zapatka, Marc, additional, Northcott, Paul A., additional, Schramm, Kathrin, additional, Belic, Jelena, additional, Jones, David T.W., additional, Tschida, Barbara, additional, Moriarity, Branden, additional, Largaespada, David, additional, Roussel, Martine F., additional, Korshunov, Andrey, additional, Reifenberger, Guido, additional, Pfister, Stefan M., additional, Lichter, Peter, additional, Kawauchi, Daisuke, additional, and Gronych, Jan, additional

Published
2015
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46. Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

Author

Zuckermann, Marc, primary, Hovestadt, Volker, additional, Knobbe-Thomsen, Christiane B., additional, Zapatka, Marc, additional, Northcott, Paul A., additional, Schramm, Kathrin, additional, Belic, Jelena, additional, Jones, David T. W., additional, Tschida, Barbara, additional, Moriarity, Branden, additional, Largaespada, David, additional, Roussel, Martine F., additional, Korshunov, Andrey, additional, Reifenberger, Guido, additional, Pfister, Stefan M., additional, Lichter, Peter, additional, Kawauchi, Daisuke, additional, and Gronych, Jan, additional

Published
2015
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48. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA

Author

Buhl, Juliane L., Selt, Florian, Hielscher, Thomas, Felix Sahm, Capper, David, Schramm, Kathrin, Ridinger, Johannes, Usta, Diren, Ecker, Jonas, Oehme, Ina, Tilburg, Cornelis M., Kool, Marcel, Deimling, Andreas, Schuhmann, Martin U., Korshunov, Andrey, Pfister, Stefan M., Brummer, Tilman, Jones, David T. W., Witt, Olaf, and Milde, Till

49. 'Raus mit der Sprache': Aktuelle Bemühungen um eine strafprozessuale Reformierung des Zeugnisverweigerungsrechts für Handlungsfelder Sozialer Arbeit

Author

Beć, Ronald, Schramm, Kathrin, Rudolph, Martin, and Technische Universität Dresden

Subjects
ddc:370, Soziale Arbeit, Zeugnisverweigerungsrecht, Schweigepflicht, Sozialpädagogik, Sozialarbeit
Abstract

In der sozialpädagogischen Arbeit können Situationen entstehen, in denen Fachkräften vertrauliche Informationen zuteil werden, deren Schutz im Eigeninteresse der Adressat*innen oder des Staates liegen kann. Insbesondere die niedrigschwellige Arbeit mit Personen und Gruppen, die aus verschiedenen Gründen eine skeptische bis ablehnende Haltung gegenüber institutionellen Strukturen einnehmen – also mitunter auch Einrichtungen, für die Sozialarbeiter*innen tätig sind – oder mit Menschen, die beispielsweise aufgrund stoffgebundener Abhängigkeiten oder Verwicklungen in als extremistisch definierten Gruppen Strafverfolgung befürchten, erfordert von Sozialarbeiter*innen ein hohes Maß an Sensibilität für die eigene Rolle als Geheimnisträger nach § 203 Strafgesetzbuch (StGB). Gleiches gilt für Hilfesuchende, die sich an Opferberatungsstellen wenden und womöglich aus persönlichen Gründen ein Strafverfahren ablehnen, auch wenn sie selbst nicht beschuldigt wären. Die im Vertrauen von Adressat*innen erlangte Erkenntnis unterliegt zwar der Schweigepflicht, dies sichert den Sozialarbeiter*innen mit staatlicher Anerkennung im Strafverfahren allerdings kein Zeugnisverweigerungsrecht nach § 53 Strafprozessordnung (StPO) zu. Beides sind unterschiedliche rechtliche Regelungen, allerdings gibt es mit Ärzt*innen, Rechtsanwält*innen, Psycholog*innen, Journalist*innen, etc. Berufsgruppen, die in beiden Gesetzestexten berücksichtigt werden. Für Sozialarbeiter*innen gilt dieser Umstand nicht, ein Zeugnisverweigerungsrecht steht ihnen im Strafverfahren, mit Ausnahme von entsprechend qualifizierten Mitarbeiter*innen in Schwangerschaftsberatungsstellen sowie Beratungsstellen für Betäubungsmittelabhängige, nicht zu. Die vorliegende Masterarbeit beleuchtet die rechtliche und fachliche Aspekte des fehlenden Zeugnisverweigerungsrecht in der Sozialen Arbeit, die aktuellen Reformbemühungen aus Praxis und Wissenschaft sowie die Auswirkungen des fehlenden Zeugnisverweigerungsrechts auf die Praxis aus Sicht von Fachkräften.:1. Thematische Einführung 1.1 Begründung zur Begriffsauswahl der „Sozialarbeiter*in“ 1.2 Zeugnisverweigerungsrecht für Sozialarbeiter*innen?! 2. Juristische Dimension 2.1 Schweigepflicht nach § 203 StGB 2.2 Regelungen der Strafprozessordnung 2.2.1 Zeugnisverweigerungsrecht nach § 53 StPO 2.2.2 Spezifische sozialpädagogische Arbeitsbereiche in § 53 StPO 2.2.3 Genehmigungsvorbehalt nach § 54 StPO 2.3 Relevante Vorschriften aus den Sozialgesetzbüchern 3. Methodischer Forschungsstand 4. Konzept der Untersuchung 4.1 Methodenwahl 4.2 Vorüberlegungen zur Durchführung der Untersuchung 4.3 Datenschutz und -sicherung 4.4 Vorüberlegungen zum Auswertungsvorgehen 5. Ergebnisse 5.1 Vorstellung der Gesprächspartner*innen 5.2 Qualitative Analyse der Interviewdaten 5.2.1 Beschreibung struktureller Rahmenbedingungen 5.2.2 Wissensbestände über Datenschutz und spezifische Rechtsfragen 5.2.3 Erwartungen an ein Zeugnisverweigerungsrecht 5.2.4 Beschreibung von Erfahrungen und Praxisbeispielen 5.2.5 Handlungsstrategien in strafrelevanten Situationen 5.2.6 Beziehung zwischen Adressat*innen und Sozialarbeiter*innen 5.2.7 Professionsbezogenes Selbstbild 5.2.8 Umgang zwischen Sozialarbeiter*innen und Sicherheitsbehörden 5.2.9 Transparenz als Arbeitsprinzip 5.2.10 Vertraulichkeit als Arbeitsprinzip 5.2.11 Auseinandersetzungen mit Arbeitsaufträgen und Erwartungen 5.2.12 Auswirkungen bei Verletzung der Vertraulichkeit 5.2.13 Herausforderungen im Umgang mit Vorladungen 5.2.14 Auswirkungen eines fehlenden Zeugnisverweigerungsrechts 6. Diskussion 7. Ausblick 8. Quellen- und Literaturverzeichnis 9. Anhangsverzeichnis

Published
2018

50. [The Tübingen questionnaire of treatment satisfaction].

Author

Längle G, Schwärzler F, Eschweiler GW, Renner G, Schramm K, and Waschulewski H

Subjects
Germany, Hospitals, Psychiatric statistics & numerical data, Humans, Mathematical Computing, Outcome Assessment, Health Care statistics & numerical data, Patient Discharge statistics & numerical data, Psychometrics, Surveys and Questionnaires, Patient Admission statistics & numerical data, Patient Satisfaction statistics & numerical data, Quality Assurance, Health Care statistics & numerical data, Schizophrenia therapy, Schizophrenic Psychology
Abstract

Objective: Development of an instrument to assess patient satisfaction with inpatient psychiatric treatment as one component of quality of care., Methods and Results: The TUBB 2000 has been developed in four steps (n = 80; n = 111; n = 104; n = 135) and covers the inpatients' satisfaction with 22 areas of psychiatric care. Three factors were extracted: "atmosphere", "quality of treatment", "autonomy". The relationship to the therapeutic staff was especially important for the patients. Intervention variables had no significant impact on patients' satisfaction. Answers to change oriented questions have been less variable than to a state oriented questions., Conclusion: The construct patients' satisfaction implies many methodological pitfalls. The TUBB 2000 can provide useful change sensitive data of patients' satisfaction with the quality of care in a psychiatric unit. It may help to increase quality of inpatient care in psychiatry.

Published
2002
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