23 results on '"Schröder‐Kraft, C."'
Search Results
2. Berufliches allergisches Kontaktekzem bei Spättyp-Sensibilisierungen gegenüber Alterungsschutzmittel der PPD-Gruppe: FV01/05
- Author
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Clausen, C, Schröder-Kraft, C M, and John, S M
- Published
- 2011
3. Streuendes allergisches Kontaktekzem durch Schutzhandschuhe: FV02/07
- Author
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Schröder-Kraft, C M, Trowe, S, and John, S M
- Published
- 2011
4. Berufliche Lichtschädigung der Haut - M. Bowen und Aktinische Keratosen bei einem Matrosen: FV01/04
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Dinkloh, A E, Schröder-Kraft, C M, and John, S M
- Published
- 2011
5. Artifizielle Dermatitis - eine diagnostische Herausforderung: FV01/01
- Author
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Clausen, C, Schröder-Kraft, C M, and John, S M
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- 2011
6. Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000‐2015: a retrospective multicentre study
- Author
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Dickel, H., primary, Kuhlmann, L., additional, Bauer, A., additional, Bircher, A.J., additional, Breuer, K., additional, Fuchs, T., additional, Grabbe, J., additional, Mahler, V., additional, Pföhler, C., additional, Przybilla, B., additional, Rieker‐Schwienbacher, J., additional, Schröder‐Kraft, C., additional, Simon, D., additional, Treudler, R., additional, Weisshaar, E., additional, Worm, M., additional, Trinder, E., additional, and Geier, J., additional
- Published
- 2020
- Full Text
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7. Erratum: Contact sensitization to plants of the Compositae family: Data of the Information Network of Departments of Dermatology (IVDK) from 2007 to 2016 (vol 80, pg 222, 2019)
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Baron, J. M., Grabbe, J., Ludwig, A., Bircher, A., Laubstein, B., Zuberbier, T., Worm, M., Simon, D., Effendy, Isaak, Dickel, H., Fartasch, M., Meyersburg, D., Patsinakidis, N., Zutt, M., Große-Hüttmann, P., Hausenblas, P., Martin, V., Reich, K., Breuer, K., Vieluf, D., Jung, A., Lippert, U., Pilz, B., Frosch, P. J., Mydlach, B., Pirker, C., Herbst, R., Kügler, K., Beiteke, U., Richter, G., Aschoff, R., Spornraft-Ragaller, P., Bauer, A., Koch, A., Peters, K. -P., Diepgen, T. L., Hertl, M., Mahler, V., Wagner, N., Ockenfels, H. -M., Hillen, U., Schwantes, H., Szliska, Ch., Geier, J., Meyer, J., Grunwald-Delitz, H., Kaatz, M., Kränke, B., Aberer, W., Jünger, M., Fuchs, Th., Buhl, T., Gaber, G., Lübbe, D., Kreft, B., Kiehn, M., Wessbecher, R., Coors, E., Witte, J., Seemann, U., Schröder-Kraft, C., Schaefer, T., Werfel, Th., Kapp, A., Schulze-Dirks, A., Hartmann, M., Jappe, U., Schäkel, K., Weisshaar, E., Löffler, H., Bahmer, F. A., Koch, P., Pföhler, C., Gebhardt, M., Wigger-Alberti, W., Schliemann, S., Brasch, J., Spring, P., Curdin, C., Treudler, R., Nestoris, St., Shimanovich, I., Hartmann, K., Recke, A., Becker, D., Bayerl, Ch., Kurzen, H., Booken, D., Klemke, C. -D., Ludwig-Peitsch, W., Schmieder, A., Pfützner, W., Hoffmann, J., Stadler, R., Oppel, T., Przybilla, B., Thomas, P., Schuh, T., Eben, R., Molin, S., Agathos, M., Ramrath, K., Georgi, M., Isbary, G., Rakoski, J., Darsow, U., Biedermann, T., Hellweg, B., Brehler, R., Behring, M., Müller, I., Debus, D., Bachtler, A., Ertner, K., Baur, V., Padeken, M., Kautz, O., Uter, W., John, S. M., Schwanitz, H. J., Schürer, N., Skudlik, Ch., Prager, W., Heise, H., Trcka, J., Rothaupt, D., Plaza, T., Nist, G., Rieker-Schwienbacher, J., Lischka, G., Roecken, M., Fischer, J., Staib, G., Hinrichs, R., Weiss, J., Arnold, J., Trautmann, A., Knopf, B., Teubner, D., Mechtel, D., Ballmer-Weber, B., and Navarini, A.
- Published
- 2019
8. Factors affecting time off work in patients with traumatic hand injuries—A bio-psycho-social perspective
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Eisele, A., primary, Dereskewitz, C., additional, Kus, S., additional, Oberhauser, C., additional, Rudolf, K.-D., additional, Coenen, M., additional, Best, C., additional, Dölz, B., additional, Drummer, N., additional, Franz, A., additional, Weißenberg, K., additional, Müller, W.-L., additional, Siemers, F., additional, Betz, C., additional, Hanebuth, G., additional, Sauerbier, M., additional, Bickert, B., additional, Struckmann, V., additional, Kneser, U., additional, Daigeler, A., additional, Höffken, O., additional, Sachs, C., additional, Lehnhardt, M., additional, Bonness, S., additional, Freund, K., additional, Schröder-Kraft, C., additional, Thielitz, A., additional, John, S.M., additional, Drisch, S., additional, Heidenreich, C., additional, Stein, V., additional, Baas, N., additional, Jänsch, P., additional, Wickert, M., additional, Eisenschenk, A., additional, Goehtz, F., additional, Weihs, N., additional, van Schoonhoven, J., additional, Heitmann, B., additional, Schreier, D., additional, Homann, H.H., additional, Nusche, A., additional, Stahl, S., additional, and Schaller, H.-E., additional
- Published
- 2018
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9. Epidemiology of patch tested patients with permanent tattoos—A comparative analysis of 9693 IVDK patients (2020–2022)
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Schubert, S., Oppel, E., Bauer, A., Schröder‐Kraft, C., Löffler, H., Strom, K., Worm, M., Brans, R., Wagner, N., Angela, Y., and Geier, J.
- Subjects
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TATTOOING , *MEDICAL personnel , *SMOKING , *ATOPIC dermatitis , *COMPARATIVE studies - Abstract
Background Objectives Patients and Methods Results Conclusions Permanent tattooing is the invasive introduction of tattoo ink (pigments) into the dermis. The ink and aftercare cosmetics applied on pre‐damaged skin may contain skin sensitisers.To identify patient characteristics and the pattern of sensitisation in tattooed patients patch tested within the Information Network of Departments of Dermatology (IVDK).Comparative analysis of patient characteristics and reaction frequencies to baseline series allergens in 1648 consecutive patients with and 8045 consecutive patients without permanent tattoos. Non‐overlapping 95%‐confidence intervals were considered as significant.Having permanent tattoos was related with female sex, age <40 years, tobacco smoking, atopic dermatitis, (occupational) hand dermatitis and being employed in particular occupational groups (e.g., healthcare workers, mechanics, hairdressers). Sensitisation to nickel was increased in tattooed patients and associated with female sex (OR 4.23 [95%‐CI, 3.48–5.18]), age ≥40 years (OR 1.26 [95%‐CI, 1.08–1.49]), tobacco smoking (OR 1.19 [95%‐CI, 1.01–1.40]) and having permanent tattoos (OR 1.27 [95%‐CI, 1.05–1.53]).The association between nickel sensitisation and permanent tattoos is probably confounded by past reactions to pierced costume jewellery. Socio‐economic factors most probably contribute to the connection between tattoos, tobacco smoking, occupational or hand dermatitis, and being employed in particular occupational groups. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Atopy patch testing with aeroallergens in a large clinical population of dermatitis patients in Germany and Switzerland, 2000-2015: a retrospective multicentre study
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Dickel, H, Kuhlmann, L, Bauer, A, Bircher, A J, Breuer, K, Fuchs, T, Grabbe, J, Mahler, V, Pföhler, C, Przybilla, B, Rieker-Schwienbacher, J, Schröder-Kraft, C, Simon, Dagmar, Treudler, R, Weisshaar, E, Worm, M, Trinder, E, and Geier, J
- Subjects
610 Medicine & health ,3. Good health - Abstract
BACKGROUND The diagnostic significance of the atopy patch test for the management of dermatitis possibly triggered by aeroallergens is still controversial. However, sufficiently large studies with routinely tested standardized aeroallergen patch test preparations in dermatitis patients are lacking. OBJECTIVE To evaluate the reaction frequency and the reaction profiles of 10 until mid-2015 commercially available, standardized aeroallergen patch test preparations of the 'Stallerpatch' test series (Stallergenes, Antony Cedex, France) in a large multicentre patient cohort. METHODS A retrospective data analysis of patients with suspected aeroallergen-dependent eczematous skin lesions was performed, who were patch tested in 15 Information Network of Departments of Dermatology-associated clinics between 2000 and 2015. Patients were stratified according to their atopic dermatitis (AD) status. RESULTS The study group included 3676 patients (median age 41 years, 34.8% males, 54.5% AD). The most common aeroallergens causing positive patch test reactions were Dermatophagoides pteronyssinus (19.6%), Dermatophagoides farinae (16.9%), birch (6.2%), timothy grass (6.0%), cat dander (5.4%), mugwort (4.9%) and dog dander (4.6%). Reactions to other pollen allergen preparations, that is 5 grasses (3.2%), cocksfoot (2.1%) and plantain (1.6%), were less common. Positive patch test reactions to aeroallergens were consistently more frequent in patients with AD. These patients showed proportionally less dubious, follicular, irritant and weak positive reactions. Independent of AD status, a patient history of past or present allergic rhinitis was associated with an increased chance of a positive aeroallergen patch test reaction to pollen allergens. CONCLUSION The aeroallergen patch test is a useful add-on tool in clinical routine, especially in patients with AD and/or respiratory allergy. A patch test series comprising Dermatophagoides pteronyssinus, Dermatophagoides farinae, birch, timothy grass, cat dander and mugwort seems to be suitable. Controlled studies with specific provocation and elimination procedures are required to further evaluate the diagnostic significance of the proposed screening series.
11. Evaluation of comfort gloves made of semipermeable and textile materials in patients with hand dermatoses: Results of a controlled multicenter intervention study (ProTection II).
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Heichel T, Kersten JF, Braumann A, Krambeck K, Bonness S, Schröder-Kraft C, Ofenloch R, Weisshaar E, Strom K, Skudlik C, Sonsmann FK, Wilke A, Nienhaus A, John SM, and Brans R
- Abstract
Background: Comfort gloves are used in the management of hand dermatoses., Objectives: To compare the acceptance and tolerability of comfort gloves made of different materials in patients with hand dermatoses and their effects on skin lesions., Methods: In a prospective multicenter study, 284 patients with hand dermatoses were invited to wear either a cotton glove (COT) or a semipermeable Sympatex glove underneath a cotton glove (SYM/COT) for two subsequent phases of 19 consecutive nights each. A total of 88 controls were asked not to wear any comfort gloves overnight. The severity of skin lesions over time was examined. Questionnaires were used to assess health-related quality of life (HRQoL) and acceptance and tolerability of the gloves., Results: The hand dermatoses improved in all groups. No substantial intergroup differences regarding severity and HRQoL were observed. SYM/COT received better ratings regarding climate conditions and tactility while COT showed superiority in fit, wearing comfort, and practicality., Conclusions: We confirmed that SYM/COT and COT are well tolerated and accepted suggesting that SYM/COT is a good alternative for COT as comfort gloves in patients with hand dermatoses. Individual requirements, needs, and preferences may direct the material choice., (© 2024 The Author(s). Contact Dermatitis published by John Wiley & Sons Ltd.)
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- 2024
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12. Epidemiological case-control study on contact sensitisation in female foot care specialists with occupational contact dermatitis: Patch test data of the Information Network of Departments of Dermatology (IVDK), 2008 to 2022.
- Author
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Brans R, Schröder-Kraft C, Gina M, Heratizadeh A, Weisshaar E, Bauer A, Strom K, Skudlik C, and Schubert S
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- Humans, Female, Retrospective Studies, Adult, Middle Aged, Case-Control Studies, Allergens adverse effects, Facial Dermatoses epidemiology, Facial Dermatoses etiology, Cosmetics adverse effects, Disinfectants adverse effects, Gloves, Protective adverse effects, Foot Dermatoses epidemiology, Dermatitis, Occupational epidemiology, Dermatitis, Occupational etiology, Dermatitis, Occupational diagnosis, Dermatitis, Allergic Contact etiology, Dermatitis, Allergic Contact epidemiology, Dermatitis, Allergic Contact diagnosis, Patch Tests, Hand Dermatoses epidemiology, Hand Dermatoses etiology, Dermatitis, Irritant epidemiology, Dermatitis, Irritant etiology
- Abstract
Background: Mainly women work as foot care specialists (FCS). They are at risk to develop occupational dermatitis (OD)., Objectives: The objective of this study is to describe the contact sensitisation pattern of female FCS with OD., Methods: In a retrospective study, patch test and clinical data collected by the Network of Departments of Dermatology (IVDK) from 2008 to 2022 were analysed. Data of 116 female FCS with OD were compared with data of 13 930 female patients with OD working in other professions and 78 612 female patients without OD., Results: Hand dermatitis (93.1%) was significantly more common and face dermatitis (0.9%) significantly less common in female FCS with OD compared to other female patients with or without OD. Frequent suspected allergen sources were disinfectants, gloves, leave-on and nail cosmetics. Occlusion and wetness were important co-factors. The most common diagnoses were irritant contact dermatitis (26.7%) and allergic contact dermatitis (21.6%). No sensitisation to any of the baseline series allergens was significantly more frequent in female FCS with OD than in the two control groups. However, sensitisations to allergens which FCS are abundantly exposed to, including fragrances, preservatives, rubber ingredients and disinfectants, were most common., Conclusions: FCS should be aware of the OD risk and prevention should be promoted., (© 2024 The Author(s). Contact Dermatitis published by John Wiley & Sons Ltd.)
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- 2024
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13. [Hand eczema or psoriasis: update on the FB 323 study occupational dermatology cohort].
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Bentz P, Eyerich K, Skudlik C, Schröder-Kraft C, Löffler H, Pföhler C, Leitz R, Thölken K, and Weisshaar E
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- Humans, Middle Aged, Retrospective Studies, Dermatitis, Occupational diagnosis, Dermatology, Hand Dermatoses diagnosis, Eczema diagnosis, Psoriasis diagnosis
- Abstract
In daily dermatological practice, the distinction between eczema and psoriasis in dermatoses of the hands can be difficult. However, a clear diagnosis is necessary to initiate optimal therapy and management. In recent years, the so-called molecular classifier has been developed for optimized differentiation of eczema and psoriasis. An occupational dermatological cohort has been established at Heidelberg University Hospital since 2020. It is funded by the German Statutory Accident Insurance. The aim is to follow-up patients over 3 years where this new diagnostic method is used and to compare the results with a retrospective occupational dermatological cohort. Recruitment ended in December 2022. The current analysis reports participants' occupational activity, insurance status, disease progression, and number of sick days. A total of 287 patients were included; mean age was 50.4 years and 63.5% (n = 181) were undergoing treatment at the expense of the liable statutory accident insurance at the start of the study. About 50% of the patients worked in health professions, metal industry, or construction. The average duration of occupational dermatosis was 6.5 years. In 38.9% of the patients, the clinical diagnosis had been classified as unclear by the treating dermatologist. By using the molecular classifier, the diagnosis could be clarified in 98% of the cases (eczema vs. psoriasis). The first analyses demonstrate that the molecular classifier contributes to improving therapy by optimizing the diagnosis., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
- Published
- 2023
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14. 2,4,6-Tris(dimethylaminomethyl)phenol: The allergen which came in from the cold.
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Geier J, Dickel H, Schröder-Kraft C, Gina M, Simon D, Weisshaar E, Lang C, Brans R, Bauer A, Löffler H, and Schubert S
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- Humans, Phenol, Phenols, Epoxy Resins, Patch Tests, Allergens, Dermatitis, Allergic Contact
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- 2023
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15. Patch testing shellac in consecutive patients-Data of the Information Network of Departments of Dermatology (IVDK) 2021.
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Schubert S, Worm M, Dickel H, Wagner N, Brans R, Schröder-Kraft C, Bauer A, Koch A, and Geier J
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- Humans, Patch Tests, Allergens, Information Services, Germany, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology, Dermatology
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- 2023
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16. Contact sensitizations in massage therapists with occupational contact dermatitis: Patch test data of the Information Network of Departments of Dermatology, 2008-2020.
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Brans R, Schröder-Kraft C, Bauer A, Weisshaar E, Skudlik C, and Geier J
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- Humans, Patch Tests adverse effects, Retrospective Studies, Information Services, Massage, Allergens, Dermatitis, Occupational diagnosis, Dermatitis, Occupational epidemiology, Dermatitis, Occupational etiology, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact epidemiology, Dermatitis, Allergic Contact etiology, Dermatology, Perfume, Oils, Volatile adverse effects
- Abstract
Background: Massage therapists are particularly exposed to constituents of massage preparations, wet work and mechanical strain and therefore, at high risk to develop occupational dermatitis (OD)., Objectives: To describe the sensitization spectrum of massage therapists with OD., Patients and Methods: In a retrospective study, patch test data of patients with OD (128 massage therapists and 24 374 patients working in other professions) collected by the Network of Departments of Dermatology (IVDK, 2008-2020) were analysed., Results: Hand dermatitis (91.4%) and allergic contact dermatitis (34.4%) were common in massage therapists with OD. Most frequent were sensitizations to fragrances/essential oils which were found in 54 (42.2%) massage therapists and thus, more often than in other patients with OD. Concomitant positivity to several fragrances/essential oils was frequent. In 8 (14.8%) of the 54 massage therapists, sensitizations to fragrances/essential oils were not detected with the baseline series, but only with special fragrance series., Conclusions: Allergic contact dermatitis is common in massage therapists with OD and is mainly caused by fragrances and essential oils. Hence, massage therapists should be aware of this risk. When OD is suspected, not only the baseline series, but also special fragrance series should be patch tested in this occupational group., (© 2022 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
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- 2023
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17. The benefit of late readings in patch testing depends both on allergen and patient characteristics.
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Forkel S, Schubert S, Dickel H, Gina M, Schröder-Kraft C, Vieluf D, Brans R, Kreft B, Wurpts G, Geier J, and Buhl T
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- Humans, Middle Aged, Patch Tests methods, Retrospective Studies, Allergens, Dermatitis, Allergic Contact diagnosis, Dermatitis, Allergic Contact etiology
- Abstract
Background: Patch test (PT) readings are recommended after 48 h and 72 h (D3). An additional day 7 (D7) reading has been suggested by some, although data on efficient patient selection are scarce. We investigated positive D7 reactions regarding (i) allergens in the baseline series and additional PT series of the German Contact Dermatitis Research Group (DKG) and (ii) characteristics of the patients tested., Methods: Retrospective, multicentre analysis of 190 allergens derived from 17 DKG test series in 4687 patients with an additional D7 reading. Patients were patch tested with the baseline series and additional series, if required. Occurrence of novel D7 reactions as well as increasing skin reactions from D3 to D7 was analysed separately., Results: Depending on the allergen tested, waiving D7 readings would have missed 4.4-26.8% of positive PT results. Patch test series with the highest number of novel D7 reactions were baseline series, metal series, and leather/shoe series. New positive reactions on D7 were associated with age over 50 years and with a negative irritant control containing sodium lauryl sulphate. Of note, application of the PT allergens for 48 h instead of 24 h was positively associated with late PT reactions., Conclusion: Within the most frequently tested allergens, without late readings, on average 11.7% of sensitizations would have been missed. Novel late reacting allergens were identified. This study comprehensively dissects patient-, allergen- and test-dependent parameters in support for D7 readings. We propose to always consider late readings individually based on effort-benefit considerations., (© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
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- 2022
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18. Very late reactions in the patch test with fragrance mix I and oak moss absolute (Evernia prunastri, INCI): Data of the Information Network of Departments of Dermatology (IVDK).
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Schubert S, Schnuch A, Bauer A, Wagner N, Schröder-Kraft C, Dickel H, Weisshaar E, Effendy I, Becker D, Buhl T, Simon D, Koch A, Kreft B, Vieluf D, Löffler H, and Geier J
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- Humans, Odorants, Parmeliaceae, Time Factors, Allergens administration & dosage, Patch Tests methods
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- 2022
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19. A negative breakdown test in a fragrance mix I-positive patient does not rule out contact allergy to its fragrance constituents.
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Geier J, Schubert S, Schnuch A, Szliska C, Weisshaar E, Kränke B, Werfel T, Ruëff F, Schröder-Kraft C, and Buhl T
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- Adult, Dermatitis, Atopic diagnosis, Dermatitis, Occupational diagnosis, False Negative Reactions, False Positive Reactions, Hand Dermatoses diagnosis, Humans, Leg Dermatoses diagnosis, Male, Retrospective Studies, Dermatitis, Allergic Contact diagnosis, Odorants, Patch Tests methods
- Abstract
Background: In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false-positive, or the breakdown test is false-negative., Objectives: To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents., Patients and Methods: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and ≥1 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19 790)., Results: Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non-fragrance baseline series allergens), Group II rather resembled Group I., Conclusions: Not every positive reaction to FM I in patients with negative breakdown tests is false-positive. There may be false-negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended., (© 2021 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
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- 2021
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20. Contact sensitization in metalworkers: Data from the information network of departments of dermatology (IVDK), 2010-2018.
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Schubert S, Brans R, Reich A, Buhl T, Skudlik C, Schröder-Kraft C, Gina M, Weisshaar E, Mahler V, Dickel H, Schön MP, John SM, and Geier J
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- Adult, Dermatitis, Allergic Contact etiology, Dermatitis, Occupational etiology, Environmental Monitoring methods, Female, Germany, Hand Dermatoses chemically induced, Humans, Male, Middle Aged, Patch Tests, Retrospective Studies, Risk Factors, Dermatitis, Allergic Contact diagnosis, Dermatitis, Occupational diagnosis, Hand Dermatoses diagnosis, Industrial Oils adverse effects, Metallurgy, Occupational Exposure adverse effects
- Abstract
Background: Metalworkers are exposed to a variety of contact allergens by handling tools, metals, metalworking fluids (MWFs), oils and greases, rubber materials, and so on. Most large-scale reports on contact allergy due to MWFs are more than 10-years-old, and there are only few studies on contact allergy in mechanics and other metal workers not exposed to MWFs., Objectives: To describe a current spectrum of contact sensitization in metalworkers with occupational dermatitis (OD)., Patients and Methods: Retrospective analysis of patch test data collected by the Information Network of Departments of Dermatology (IVDK; 2010-2018), stratifying for 804 cutting metalworkers, 2197 mechanics, and 355 other metalworkers., Results: Cutting metalworkers were most frequently sensitized to monoethanolamine (12.6%), colophonium/abietic acid (11.4%) and formaldehyde releasers (up to 8.5%) from the MWF series, and formaldehyde (4.6%) and iodopropynyl butylcarbamate (4.6%) from the baseline series. Sensitization among mechanics and other metalworkers indicates possible occupational exposure to MWFs, glues, and resins, although this may not be expected from their job titles., Conclusions: The spectrum of MWF contact allergens remained largely unchanged during the last years. Taking a comprehensive occupational history is indispensable in order to not miss relevant allergen exposures., (© 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
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- 2020
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21. Tertiary prevention of occupational skin diseases: Prevalence of allergic contact dermatitis and pattern of patch test results.
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Brans R, Schröder-Kraft C, Skudlik C, John SM, and Geier J
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- Adult, Beauty Culture, Cohort Studies, Construction Industry, Female, Gardening, Germany epidemiology, Humans, Male, Metallurgy, Middle Aged, Paintings, Patch Tests, Prevalence, Retrospective Studies, Tertiary Prevention, Young Adult, Dermatitis, Allergic Contact epidemiology, Dermatitis, Occupational epidemiology, Facial Dermatoses epidemiology, Hand Dermatoses epidemiology
- Abstract
Background: Allergic contact dermatitis (ACD) is one of the most common occupational skin diseases (OSDs). Its prevalence and the causative allergens differ between occupations., Objectives: To evaluate the prevalence of ACD and the pattern of patch test results of patients taking part in a tertiary individual prevention programme (TIP) for OSD in Germany., Patients and Methods: In a retrospective cohort study, the data of 3411 TIP patients patch tested between 2007 and 2016 were analysed., Results: In 2687 (78.8%) patients, work-related skin disease was diagnosed, mostly hand dermatitis. The highest proportion of face dermatitis was seen in painters (8.1%). ACD was most common in painters (56.8%), hairdressers (45.8%), construction workers (31.5%), gardeners/florists (26.7%), and metalworkers (26.5%). On average, hairdressers had the youngest age (31.4 ± 12.6 years, P < 0.0001) and the shortest time in the profession prior to the TIP (mean 13.7 years). The pattern of patch test reactivity showed occupation-specific differences related to work exposures., Conclusions: Identification of occupational groups at risk for ACD and relevant allergens may help in the development and implementation of targeted prevention strategies. Our data suggest that there should be a particular focus on hairdressers and painters., (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2019
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22. A variant of the CXCL11 gene may influence susceptibility to contact allergy, particularly in polysensitized patients.
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Westphal GA, Rihs HP, Schaffranek A, Zeiler T, Werfel T, Heratizadeh A, Dickel H, Weisshaar E, Bauer A, Schliemann S, Reich K, Breuer K, Schröder-Kraft C, Worm M, Molin S, Brans R, Schäkel K, Schwantes H, Pföhler C, Szliska C, Kreft B, Löffler H, Bünger J, Brüning T, Geier J, and Schnuch A
- Subjects
- Adolescent, Adult, Aged, Case-Control Studies, Cytokines genetics, Female, Genetic Predisposition to Disease, Homozygote, Humans, Male, Middle Aged, Odds Ratio, Patch Tests, Polymorphism, Single Nucleotide, Young Adult, Chemokine CXCL11 genetics, Dermatitis, Allergic Contact genetics
- Abstract
Background: Hereditary factors may influence individual susceptibility to contact allergy., Objectives: To investigate genetic variants with impacts on early inflammatory reactions and T cell functions that possibly increase the risk of contact allergy., Patients and Methods: Three hundred and seventy two patients undergoing patch testing were recruited from the Information Network of Departments of Dermatology (IVDK). Of these, 133 were monosensitized and 239 were polysensitized, defined as reacting to three or more unrelated sensitizers. Within the polysensitized individuals, a subgroup with at least one particularly strong patch test reaction (strong reactors; n = 194) was considered. Three hundred and forty-seven blood bank donors served as controls. Fifteen genetic variants in 13 genes were analysed., Results: The homozygous variant CXCL11 AA genotype (rs6817952) was significantly more frequent among polysensitized patients (10 of 239 = 4.2%; p = 0.0048; odds ratio 7.49; 95%CI: 1.7-36.1) than among monosensitized patients (2.2%) and in the control group (0.6%). None of the remaining genetic variants investigated were characterized by similarly strong associations. However, the significance was lost after correction for multiple comparisons., Conclusions: The homozygous variant CXCL11 genotype is associated with an increased risk of contact allergy. To confirm this exploratory finding, further independent studies are needed., (© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
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23. Medical documentation, bioanalytical evidence of an accidental human exposure to sulfur mustard and general therapy recommendations.
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Steinritz D, Striepling E, Rudolf KD, Schröder-Kraft C, Püschel K, Hullard-Pulstinger A, Koller M, Thiermann H, Gandor F, Gawlik M, and John H
- Subjects
- Adult, Blister diagnosis, Blister therapy, Chemical Warfare Agents metabolism, Chromatography, Liquid, Erythema diagnosis, Erythema therapy, Gas Chromatography-Mass Spectrometry, Humans, Male, Middle Aged, Mustard Gas metabolism, Poisoning diagnosis, Poisoning therapy, Protein Binding, Remission Induction, Serum Albumin metabolism, Serum Albumin, Human, Severity of Illness Index, Skin pathology, Tandem Mass Spectrometry, Time Factors, Treatment Outcome, Accidents, Blister chemically induced, Chemical Warfare Agents poisoning, Documentation, Erythema chemically induced, Irritants poisoning, Mustard Gas poisoning, Skin drug effects
- Abstract
Sulfur mustard (SM) is a chemical warfare agent (CWA) that was first used in World War I and in several military conflicts afterwards. The threat by SM is still present even today due to remaining stockpiles, old and abandoned remainders all over the world as well as to its ease of synthesis. CWA are banned by the Chemical Weapons Convention (CWC) interdicting their development, production, transport, stockpiling and use and are subjected to controlled destruction. The present case report describes an accidental exposure of three workers that occurred during the destruction of SM. All exposed workers presented a characteristic SM-related clinical picture that started about 4h after exposure with erythema and feeling of tension of the skin at the upper part of the body. Later on, superficial blister and a burning phenomenon of the affected skin areas developed. Similar symptoms occurred in all three patients differing severity. One patient presented sustained skin affections at the gluteal region while another patient came up with affections of the axilla and genital region. Fortunately, full recovery was observed on day 56 after exposure except some little pigmentation changes that were evident even on day 154 in two of the patients. SM-exposure was verified for all three patients using bioanalytical GC MS and LC MS/MS based methods applied to urine and plasma. Urinary biotransformation products of the β-lyase pathway were detected until 5 days after poisoning whereas albumin-SM adducts could be found until day 29 underlining the beneficial role of adduct detection for post-exposure verification. In addition, we provide general recommendations for management and therapy in case of SM poisoning., (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2016
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