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Your search keyword '"Schröder, Klaus R."' showing total 15 results
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15 results on '"Schröder, Klaus R."'

7. Degradable Glycine-Based Photo-Polymerizable Polyphosphazenes for Use as Scaffolds for Tissue Regeneration

Author

Rothemund, Sandra, primary, Aigner, Tamara B., additional, Iturmendi, Aitziber, additional, Rigau, Maria, additional, Husár, Branislav, additional, Hildner, Florian, additional, Oberbauer, Eleni, additional, Prambauer, Martina, additional, Olawale, Gbenga, additional, Forstner, Reinhard, additional, Liska, Robert, additional, Schröder, Klaus R., additional, Brüggemann, Oliver, additional, and Teasdale, Ian, additional

Published
2014
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9. Barriers to Validation

Author

Ahr, Hans-Jürgen, primary, Alepée, Nathalie, additional, Breier, Siegfried, additional, Brekelmans, Cornelis, additional, Cotgreave, Ian, additional, Gribaldo, Laura, additional, Dal Negro, Gianni, additional, De Silva, Odile, additional, Hartung, Thomas, additional, Lacerda, Antonio, additional, Leblanc, Bernard, additional, Lecerf, Catherine, additional, Linge, Jens P., additional, Louhimies, Susanna, additional, Manou, Irene, additional, Maxwell, Gavin, additional, Müller, Karsten K., additional, Pape, Wolfang, additional, Redhead, Keith, additional, Schröder, Klaus R., additional, Sladowski, Dariusz, additional, van der Jagt, Katinka, additional, and Vanparys, Phillipe, additional

Published
2008
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13. Barriers to Validation: A Report by European Partnership for Alternative Approaches to Animal Testing (EPAA) Working Group 5a

Author

Ahr, Hans-Jürgen, Alepée, Nathalie, Breier, Siegfried, Brekelmans, Cornelis, Cotgreave, Ian, Gribaldo, Laura, Dal Negro, Gianni, De Silva, Odile, Hartung, Thomas, Lacerda, Antonio, Leblanc, Bernard, Lecerf, Catherine, Linge, Jens P., Louhimies, Susanna, Manou, Irene, Maxwell, Gavin, Müller, Karsten K., Pape, Wolfang, Redhead, Keith, Schröder, Klaus R., Sladowski, Dariusz, van der Jagt, Katinka, and Vanparys, Phillipe

Published
2008
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14. Barriers to validation: a report by the European Partnership fo Alternative Approaches to Animal Testing (EPAA) Working Group 5.

Author

Ahr HJ, Alepée N, Breier S, Brekelmans C, Cotgreave I, Gribaldo L, Dal Negro G, De Silva O, Hartung T, Lacerda A, Leblanc B, Lecerf C, Linge JP, Louhimies S, Manou I, Maxwell G, Müller KK, Pape W, Redhead K, Schröder KR, Sladowski D, van der Jagt K, and Vanparys P

Subjects
Animals, Europe, Animal Testing Alternatives standards, Validation Studies as Topic
Published
2008
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15. Kiwi fruit (Actinidia chinensis L.) polysaccharides exert stimulating effects on cell proliferation via enhanced growth factor receptors, energy production, and collagen synthesis of human keratinocytes, fibroblasts, and skin equivalents.

Author

Deters AM, Schröder KR, and Hensel A

Subjects
Adenosine Triphosphate metabolism, Cells, Cultured, Fibroblasts cytology, Fibroblasts physiology, Humans, Keratinocytes cytology, Keratinocytes physiology, Plant Extracts pharmacology, Actinidia chemistry, Cell Proliferation drug effects, Collagen biosynthesis, Fruit chemistry, Polysaccharides isolation & purification, Polysaccharides pharmacology, Skin cytology, Skin drug effects, Skin metabolism
Abstract

Within physiological engineering exogenous carbohydrates were recently confirmed as pharmacologically active compounds. To investigate potential dermatological activity purified polysaccharides from kiwi fruits (Actinidia chinensis L., Actinidiaceae) were characterized concerning monomer composition, linkage types and molecular weights and were tested under in vitro conditions for regulating activities on cell physiology of human keratinocytes, fibroblasts, and skin equivalents. Ten micrograms per milliliter of raw polysaccharide, neutral type-II-arabinogalactans, and acidic arabinorhamnogalacturonans of kiwi fruits stimulated cell proliferation of human keratinocytes (NHK, HaCaT) up to 30% significantly while mitochondrial activity was stimulated for nearly 25% in regard to control cells. Fibroblasts were not as sensitive as keratinocytes but >130 microg/ml kiwi fruit polysaccharides increased proliferation and ATP-synthesis significantly, too. Proliferation-stimulating activity was dependent on terminal 1-alpha-l-arabinose residues since enzymatic release of these sugar moieties caused significantly decreased proliferation of HaCaT and fibroblasts of about 10% in regard to untreated cells. In three dimensional skin equivalents, it was shown that the polysaccharides led to a doubled collagen synthesis of fibroblasts compared to the normally strongly reduced biosynthetic activity., (2004 Wiley-Liss, Inc.)

Published
2005
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