485 results on '"Schouten, R."'
Search Results
2. De blik naar buiten
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Schouten, R., Derksen, W., de Jong, H., and van Enckevort, I.
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overheidsbeleid ,political science ,bic Book Industry Communication::J Society & social sciences::JP Politics & government - Abstract
Political Science, De serie 'Werkdocumenten' omvat stukken die in het kader van de werkzaamheden van de WRR tot stand zijn gekomen en die op aanvraag door de raad beschikbaar worden gesteld. De verantwoordelijkheid voor de inhoud en de ingenomen standpunten berust bij de auteurs.
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- 1995
3. Synthesis and Implementation of Distributed Supervisory Controllers with Communication Delays
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Schouten, R. H. J., Moormann, L., van de Mortel-Fronczak, J. M., and Rooda, J. E.
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Computer Science - Formal Languages and Automata Theory - Abstract
In literature, extensive research has been done with respect to synthesis of supervisory controllers. Such synthesized supervisors can be distributed for implementation on multiple physical controllers. This paper discusses a method for distributing a synthesized supervisory controller. In this method, dependency structure matrices are used to distribute a system, the supervisor is then distributed accordingly, using existing localization theory. The existence of communication delays between supervisory controllers is unavoidable in a distributed application. The influence of these delays on the behavior of a supervisor is therefore studied using delay robustness theory. This paper introduces the use of mutex algorithms to make the distributed supervisor delay-robust. A case study is used to demonstrate the method and hardware in the loop testing is used to validate the resulting distributed supervisor., Comment: 14 pages, 22 figures
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- 2021
4. A four-qubit germanium quantum processor
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Hendrickx, N. W., Lawrie, W. I. L., Russ, M., van Riggelen, F., de Snoo, S. L., Schouten, R. N., Sammak, A., Scappucci, G., and Veldhorst, M.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The prospect of building quantum circuits using advanced semiconductor manufacturing positions quantum dots as an attractive platform for quantum information processing. Extensive studies on various materials have led to demonstrations of two-qubit logic in gallium arsenide, silicon, and germanium. However, interconnecting larger numbers of qubits in semiconductor devices has remained an outstanding challenge. Here, we demonstrate a four-qubit quantum processor based on hole spins in germanium quantum dots. Furthermore, we define the quantum dots in a two-by-two array and obtain controllable coupling along both directions. Qubit logic is implemented all-electrically and the exchange interaction can be pulsed to freely program one-qubit, two-qubit, three-qubit, and four-qubit operations, resulting in a compact and high-connectivity circuit. We execute a quantum logic circuit that generates a four-qubit Greenberger-Horne-Zeilinger state and we obtain coherent evolution by incorporating dynamical decoupling. These results are an important step towards quantum error correction and quantum simulation with quantum dots., Comment: 7 pages, 5 figures, supplementary materials with 11 figures and 2 tables in separate file
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- 2020
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5. Multiplexed quantum transport using commercial off-the-shelf CMOS at sub-kelvin temperatures
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Wuetz, B. Paquelet, Bavdaz, P. L., Yeoh, L. A., Schouten, R., van der Does, H., Tiggelman, M., Sabbagh, D., Sammak, A., Almudever, C. G., Sebastiano, F., Clarke, J. S., Veldhorst, M., and Scappucci, G.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Continuing advancements in quantum information processing have caused a paradigm shift from research mainly focused on testing the reality of quantum mechanics to engineering qubit devices with numbers required for practical quantum computation. One of the major challenges in scaling toward large-scale solid-state systems is the limited input/output (I/O) connectors present in cryostats operating at sub-kelvin temperatures required to execute quantum logic with high-fidelity. This interconnect bottleneck is equally present in the device fabrication-measurement cycle, which requires high-throughput and cryogenic characterization to develop quantum processors. Here we multiplex quantum transport of two-dimensional electron gases at sub-kelvin temperatures. We use commercial off-the-shelf CMOS multiplexers to achieve an order of magnitude increase in the number of wires. Exploiting this technology we advance 300 mm epitaxial wafers manufactured in an industrial CMOS fab to a record electron mobility of (3.9$\pm$0.6)$\times$10$^5$ cm$^2$\slash Vs and percolation density of (6.9$\pm$0.4)$\times$10$^{10}$ cm$^{-2}$, representing a key step toward large silicon qubit arrays. We envision that the demonstration will inspire the development of cryogenic electronics for quantum information and because of the simplicity of assembly, low-cost, yet versatility, we foresee widespread use of similar cryo-CMOS circuits for high-throughput quantum measurements and control of quantum engineered systems.
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- 2019
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6. The Netherlands Heart Tissue Bank: Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository
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Henkens, M. T. H. M., van Ast, J. F., te Riele, A. S. J. M., Houweling, A. C., Amin, A. S., Nijveldt, R., Antoni, M. L., Li, X., Wehrens, S. M. T., von der Thüsen, J. H., Damman, K., ter Horst, E. N., Manintveld, O. C., Abma-Schouten, R. Y., Niessen, H. W. M., Silljé, H. H. W., Jukema, J. W., and Doevendans, P. A.
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- 2023
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7. Safety of bariatric surgery in the elderly: results from the Dutch National Registry
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de Brauw, L.M., Castro, S.M.M. de, Damen, S.L., Jonker, F.H.W., Apers, J.A., Faneyte, I.F., Greve, J.W.M., Hazebroek, E.J., van’t Hof, G., Janssen, I.M.C., Jutte, E.H., Klaassen, R.A., Lagae, E.A.G.L., Langenhoff, B.S., Liem, R.S.L., Luijten, A.A.P.M., Nienhuijs, S.W., Schouten, R., Smeenk, R.M., Swank, D.J., Wiezer, M.J., Vening, W., Bonouvrie, Daniëlle S., van de Pas, Kelly G.H., Janssen, Loes, Leclercq, Wouter K.G., Greve, Jan Willem M., and van Dielen, François M.H.
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- 2023
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8. Treatment of cryptoglandular fistulas with the fistula tract laser closure (FiLaC™) method in comparison with standard methods: first results of a multicenter retrospective comparative study in the Netherlands
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Sluckin, T. C., Gispen, W. H., Jongenotter, J., Hazen, S. J. A., Smeets, S., van der Bilt, J. D. W., Smeenk, R. M., and Schouten, R.
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- 2022
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9. eQASM: An Executable Quantum Instruction Set Architecture
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Fu, X., Riesebos, L., Rol, M. A., van Straten, J., van Someren, J., Khammassi, N., Ashraf, I., Vermeulen, R. F. L., Newsum, V., Loh, K. K. L., de Sterke, J. C., Vlothuizen, W. J., Schouten, R. N., Almudever, C. G., DiCarlo, L., and Bertels, K.
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Computer Science - Hardware Architecture ,Computer Science - Systems and Control ,Quantum Physics - Abstract
A widely-used quantum programming paradigm comprises of both the data flow and control flow. Existing quantum hardware cannot well support the control flow, significantly limiting the range of quantum software executable on the hardware. By analyzing the constraints in the control microarchitecture, we found that existing quantum assembly languages are either too high-level or too restricted to support comprehensive flow control on the hardware. Also, as observed with the quantum microinstruction set QuMIS, the quantum instruction set architecture (QISA) design may suffer from limited scalability and flexibility because of microarchitectural constraints. It is an open challenge to design a scalable and flexible QISA which provides a comprehensive abstraction of the quantum hardware. In this paper, we propose an executable QISA, called eQASM, that can be translated from quantum assembly language (QASM), supports comprehensive quantum program flow control, and is executed on a quantum control microarchitecture. With efficient timing specification, single-operation-multiple-qubit execution, and a very-long-instruction-word architecture, eQASM presents better scalability than QuMIS. The definition of eQASM focuses on the assembly level to be expressive. Quantum operations are configured at compile time instead of being defined at QISA design time. We instantiate eQASM into a 32-bit instruction set targeting a seven-qubit superconducting quantum processor. We validate our design by performing several experiments on a two-qubit quantum processor., Comment: 13 pages, 8 figures; added abstract, re-positioned figures
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- 2018
10. Spin lifetime and charge noise in hot silicon quantum dot qubits
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Petit, L., Boter, J. M., Eenink, H. G. J., Droulers, G., Tagliaferri, M. L. V., Li, R., Franke, D. P., Singh, K. J., Clarke, J. S., Schouten, R. N., Dobrovitski, V. V., Vandersypen, L. M. K., and Veldhorst, M.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We investigate the magnetic field and temperature dependence of the single-electron spin lifetime in silicon quantum dots and find a lifetime of 2.8 ms at a temperature of 1.1 K. We develop a model based on spin-valley mixing and find that Johnson noise and two-phonon processes limit relaxation at low and high temperature respectively. We also investigate the effect of temperature on charge noise and find a linear dependence up to 4 K. These results contribute to the understanding of relaxation in silicon quantum dots and are promising for qubit operation at elevated temperatures., Comment: 8 pages, 6 figures
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- 2018
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11. Risk factors for postoperative bleeding in bariatric surgery
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de Brauw, L.M., de Castro, S.M.M., Damen, S.L., Jonker, F., Dunkelgrün, M., Faneyte, I.F., Greve, J.W.M., Hazebroek, E.J., van ‘t Hof, G., Janssen, I.M.C., Jutte, E.H., Klaassen, R.A., Lagae, E.A.G.L., Langenhoff, B.S., Liem, R.S.L., Luijten, A.A.P.M., Nienhuijs, S.W., Schouten, R., Smeenk, R.M., Swank, D.J., Wiezer, M.J., Vening, W., Straatman, Jennifer, Verhaak, Tim, Demirkiran, Ahmet, Harlaar, Niels J., Cense, Huib A., and Jonker, Frederik H.W.
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- 2022
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12. An Experimental Microarchitecture for a Superconducting Quantum Processor
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Fu, X., Rol, M. A., Bultink, C. C., van Someren, J., Khammassi, N., Ashraf, I., Vermeulen, R. F. L., de Sterke, J. C., Vlothuizen, W. J., Schouten, R. N., Almudever, C. G., DiCarlo, L., and Bertels, K.
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Quantum Physics ,Computer Science - Hardware Architecture ,Computer Science - Emerging Technologies ,C.0, B.1.5, C.1.3 - Abstract
Quantum computers promise to solve certain problems that are intractable for classical computers, such as factoring large numbers and simulating quantum systems. To date, research in quantum computer engineering has focused primarily at opposite ends of the required system stack: devising high-level programming languages and compilers to describe and optimize quantum algorithms, and building reliable low-level quantum hardware. Relatively little attention has been given to using the compiler output to fully control the operations on experimental quantum processors. Bridging this gap, we propose and build a prototype of a flexible control microarchitecture supporting quantum-classical mixed code for a superconducting quantum processor. The microarchitecture is based on three core elements: (i) a codeword-based event control scheme, (ii) queue-based precise event timing control, and (iii) a flexible multilevel instruction decoding mechanism for control. We design a set of quantum microinstructions that allows flexible control of quantum operations with precise timing. We demonstrate the microarchitecture and microinstruction set by performing a standard gate-characterization experiment on a transmon qubit., Comment: 13 pages including reference. 9 figures
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- 2017
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13. Demonstration of an ac Josephson junction laser
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Cassidy, M. C., Bruno, A., Rubbert, S., Irfan, M., Kammhuber, J., Schouten, R. N., Akhmerov, A. R., and Kouwenhoven, L. P.
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Condensed Matter - Superconductivity ,Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Superconducting electronic devices have re-emerged as contenders for both classical and quantum computing due to their fast operation speeds, low dissipation and long coherence times. An ultimate demonstration of coherence is lasing. We use one of the fundamental aspects of superconductivity, the ac Josephson effect, to demonstrate a laser made from a Josephson junction strongly coupled to a multi-mode superconducting cavity. A dc voltage bias to the junction provides a source of microwave photons, while the circuit's nonlinearity allows for efficient down-conversion of higher order Josephson frequencies down to the cavity's fundamental mode. The simple fabrication and operation allows for easy integration with a range of quantum devices, allowing for efficient on-chip generation of coherent microwave photons at low temperatures., Comment: Supplementary Information available at https://qutech.nl/kouwenhoven-lab/publications/
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- 2017
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14. Current status and future challenges in implementing and upscaling vertical farming systems
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van Delden, S. H., SharathKumar, M., Butturini, M., Graamans, L. J. A., Heuvelink, E., Kacira, M., Kaiser, E., Klamer, R. S., Klerkx, L., Kootstra, G., Loeber, A., Schouten, R. E., Stanghellini, C., van Ieperen, W., Verdonk, J. C., Vialet-Chabrand, S., Woltering, E. J., van de Zedde, R., Zhang, Y., and Marcelis, L. F. M.
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- 2021
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15. Restless Tuneup of High-Fidelity Qubit Gates
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Rol, M. A., Bultink, C. C., O'Brien, T. E., de Jong, S. R., Theis, L. S., Fu, X., Luthi, F., Vermeulen, R. F. L., de Sterke, J. C., Bruno, A., Deurloo, D., Schouten, R. N., Wilhelm, F. K., and DiCarlo, L.
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Quantum Physics - Abstract
We present a tuneup protocol for qubit gates with tenfold speedup over traditional methods reliant on qubit initialization by energy relaxation. This speedup is achieved by constructing a cost function for Nelder-Mead optimization from real-time correlation of non-demolition measurements interleaving gate operations without pause. Applying the protocol on a transmon qubit achieves 0.999 average Clifford fidelity in one minute, as independently verified using randomized benchmarking and gate set tomography. The adjustable sensitivity of the cost function allows detecting fractional changes in gate error with nearly constant signal-to-noise ratio. The restless concept demonstrated can be readily extended to the tuneup of two-qubit gates and measurement operations.
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- 2016
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16. Microcalorimeter pulse analysis by means of principle component decomposition
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de Vries, C. P., Schouten, R. M., van der Kuur, J., Gottardi, L., and Akamatsu, H.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The X-ray integral field unit for the Athena mission consists of a microcalorimeter transition edge sensor pixel array. Incoming photons generate pulses which are analyzed in terms of energy, in order to assemble the X-ray spectrum. Usually this is done by means of optimal filtering in either time or frequency domain. In this paper we investigate an alternative method by means of principle component analysis. This method attempts to find the main components of an orthogonal set of functions to describe the data. We show, based on simulations, what the influence of various instrumental effects is on this type of analysis. We compare analyses both in time and frequency domain. Finally we apply these analyses on real data, obtained via frequency domain multiplexing readout., Comment: SPIE Astronomical Telescopes and Instrumentation; conference contribution
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- 2016
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17. Active resonator reset in the nonlinear dispersive regime of circuit QED
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Bultink, C. C., Rol, M. A., O'Brien, T. E., Fu, X., Dikken, B. C. S., Dickel, C., Vermeulen, R. F. L., de Sterke, J. C., Bruno, A., Schouten, R. N., and DiCarlo, L.
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We present two pulse schemes for actively depleting measurement photons from a readout resonator in the nonlinear dispersive regime of circuit QED. One method uses digital feedback conditioned on the measurement outcome while the other is unconditional. In the absence of analytic forms and symmetries to exploit in this nonlinear regime, the depletion pulses are numerically optimized using the Powell method. We shorten the photon depletion time by more than six inverse resonator linewidths compared to passive depletion by waiting. We quantify the benefit by emulating an ancilla qubit performing repeated quantum parity checks in a repetition code. Fast depletion increases the mean number of cycles to a spurious error detection event from order 1 to 75 at a 1 microsecond cycle time., Comment: 10 pages, 9 figures
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- 2016
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18. Loophole-free Bell test using electron spins in diamond: second experiment and additional analysis
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Hensen, B., Kalb, N., Blok, M. S., Dréau, A., Reiserer, A., Vermeulen, R. F. L., Schouten, R. N., Markham, M., Twitchen, D. J., Goodenough, K., Elkouss, D., Wehner, S., Taminiau, T. H., and Hanson, R.
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Quantum Physics - Abstract
The recently reported violation of a Bell inequality using entangled electronic spins in diamonds (Hensen et al., Nature 526, 682-686) provided the first loophole-free evidence against local-realist theories of nature. Here we report on data from a second Bell experiment using the same experimental setup with minor modifications. We find a violation of the CHSH-Bell inequality of $2.35 \pm 0.18$, in agreement with the first run, yielding an overall value of $S = 2.38 \pm 0.14$. We calculate the resulting $P$-values of the second experiment and of the combined Bell tests. We provide an additional analysis of the distribution of settings choices recorded during the two tests, finding that the observed distributions are consistent with uniform settings for both tests. Finally, we analytically study the effect of particular models of random number generator (RNG) imperfection on our hypothesis test. We find that the winning probability per trial in the CHSH game can be bounded knowing only the mean of the RNG bias, implying that our experimental result is robust for any model underlying the estimated average RNG bias., Comment: Open dataset will be made available online at http://dx.doi.org/10.4121/uuid:53644d31-d862-4f9f-9ad2-0b571874b829
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- 2016
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19. Metabolic effects of bariatric surgery on patients with type 2 diabetes: a population-based study
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de Brauw, L.M., de Castro, S.M.M., Damen, S.L., Demirkiran, A., Dunkelgrun, M., Faneyte, I.F., van ‘t Hof, G., Janssen, I.M.C., Klaassen, R.A., Lagae, E.A.G.L., Langenhoff, B.S., Luijten, A.A.P.M., Schouten, R., Smeenk, R.M., Swank, D.J., Wiezer, M.J., Vening, W., Akpinar, Erman O., Liem, Ronald S.L., Nienhuijs, Simon W., Greve, Jan Willem M., and Marang-van de Mheen, Perla J.
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- 2021
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20. Experimental loophole-free violation of a Bell inequality using entangled electron spins separated by 1.3 km
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Hensen, B., Bernien, H., Dréau, A. E., Reiserer, A., Kalb, N., Blok, M. S., Ruitenberg, J., Vermeulen, R. F. L., Schouten, R. N., Abellán, C., Amaya, W., Pruneri, V., Mitchell, M. W., Markham, M., Twitchen, D. J., Elkouss, D., Wehner, S., Taminiau, T. H., and Hanson, R.
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Quantum Physics - Abstract
For more than 80 years, the counterintuitive predictions of quantum theory have stimulated debate about the nature of reality. In his seminal work, John Bell proved that no theory of nature that obeys locality and realism can reproduce all the predictions of quantum theory. Bell showed that in any local realist theory the correlations between distant measurements satisfy an inequality and, moreover, that this inequality can be violated according to quantum theory. This provided a recipe for experimental tests of the fundamental principles underlying the laws of nature. In the past decades, numerous ingenious Bell inequality tests have been reported. However, because of experimental limitations, all experiments to date required additional assumptions to obtain a contradiction with local realism, resulting in loopholes. Here we report on a Bell experiment that is free of any such additional assumption and thus directly tests the principles underlying Bell's inequality. We employ an event-ready scheme that enables the generation of high-fidelity entanglement between distant electron spins. Efficient spin readout avoids the fair sampling assumption (detection loophole), while the use of fast random basis selection and readout combined with a spatial separation of 1.3 km ensure the required locality conditions. We perform 245 trials testing the CHSH-Bell inequality $S \leq 2$ and find $S = 2.42 \pm 0.20$. A null hypothesis test yields a probability of $p = 0.039$ that a local-realist model for space-like separated sites produces data with a violation at least as large as observed, even when allowing for memory in the devices. This result rules out large classes of local realist theories, and paves the way for implementing device-independent quantum-secure communication and randomness certification., Comment: Raw data will be made available after publication
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- 2015
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21. Management of cryptoglandular fistula-in-ano among gastrointestinal surgeons in the Netherlands
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Dekker, L., Zimmerman, D. D. E., Smeenk, R. M., Schouten, R., and Han-Geurts, I. J. M.
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- 2021
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22. Optimising primary molecular profiling in non-small cell lung cancer
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Longziekten, Cancer, Infection & Immunity, Pathologie Pathologen staf, Schouten, R D, Schouten, I, Schuurbiers, M M F, van der Noort, V, Damhuis, R A M, van der Heijden, E H F M, Burgers, J A, Barlo, N P, van Lindert, A S R, Maas, K W, van den Brand, J J G, Smit, A A J, van Haarst, J M W, van der Maat, B, Schuuring, E, Blaauwgeers, H, Willems, S M, Monkhorst, K, van den Broek, D, van den Heuvel, M M, Longziekten, Cancer, Infection & Immunity, Pathologie Pathologen staf, Schouten, R D, Schouten, I, Schuurbiers, M M F, van der Noort, V, Damhuis, R A M, van der Heijden, E H F M, Burgers, J A, Barlo, N P, van Lindert, A S R, Maas, K W, van den Brand, J J G, Smit, A A J, van Haarst, J M W, van der Maat, B, Schuuring, E, Blaauwgeers, H, Willems, S M, Monkhorst, K, van den Broek, D, and van den Heuvel, M M
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- 2024
23. Joint 2D to 3D image registration workflow for comparing multiple slice photographs and CT scans of apple fruit with internal disorders
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Schut, D.E. (Dirk), Wood, R.M. (Rachael), Trull, A.K. (Anna), Schouten, R. (Rob), Liere, R. (Robert) van, Leeuwen, T. (Tristan) van, Batenburg, K.J. (Joost), Schut, D.E. (Dirk), Wood, R.M. (Rachael), Trull, A.K. (Anna), Schouten, R. (Rob), Liere, R. (Robert) van, Leeuwen, T. (Tristan) van, and Batenburg, K.J. (Joost)
- Abstract
A large percentage of apples are affected by internal disorders after long-term storage, which makes them unacceptable in the supply chain. CT imaging is a promising technique for in-line detection of these disorders. Therefore, it is crucial to understand how different disorders affect the image features that can be observed in CT scans. This paper presents a workflow for creating datasets of image pairs of photographs of apple slices and their corresponding CT slices. By having CT and photographic images of the same part of the apple, the complementary information in both images can be used to study the processes underlying internal disorders and how internal disorders can be measured in CT images. The workflow includes data acquisition, image segmentation, image registration, and validation methods. The image registration method aligns all available slices of an apple within a single optimization problem, assuming that the slices are parallel. This method outperformed optimizing the alignment separately for each slice. The workflow was applied to create a dataset of 1347 slice photographs and their corresponding CT slices. The dataset was acquired from 107 ‘Kanzi’ apples that had been stored in controlled atmosphere (CA) storage for 8 months. In this dataset, the distance between annotations in the slice photograph and the matching CT slice was, on average, 1.47 ± 0.40 mm. Our workflow allows collecting large datasets of accurately aligned photo-CT image pairs, which can help distinguish internal disorders with a similar appearance on CT. With slight modifications, a similar workflow can be applied to other fruits or MRI instead of CT scans.
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- 2024
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24. Reversing quantum trajectories with analog feedback
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de Lange, G., Ristè, D., Tiggelman, M. J., Eichler, C., Tornberg, L., Johansson, G., Wallraff, A., Schouten, R. N., and DiCarlo, L.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
We demonstrate the active suppression of transmon qubit dephasing induced by dispersive measurement, using parametric amplification and analog feedback. By real-time processing of the homodyne record, the feedback controller reverts the stochastic quantum phase kick imparted by the measurement on the qubit. The feedback operation matches a model of quantum trajectories with measurement efficiency $\tilde{\eta} \approx 0.5$, consistent with the result obtained by postselection. We overcome the bandwidth limitations of the amplification chain by numerically optimizing the signal processing in the feedback loop and provide a theoretical model explaining the optimization result., Comment: 5 pages, 4 figures, and Supplementary Information (7 figures)
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- 2013
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25. Deterministic entanglement of superconducting qubits by parity measurement and feedback
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Ristè, D., Dukalski, M., Watson, C. A., de Lange, G., Tiggelman, M. J., Blanter, Ya. M., Lehnert, K. W., Schouten, R. N., and DiCarlo, L.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
The stochastic evolution of quantum systems during measurement is arguably the most enigmatic feature of quantum mechanics. Measuring a quantum system typically steers it towards a classical state, destroying any initial quantum superposition and any entanglement with other quantum systems. Remarkably, the measurement of a shared property between non-interacting quantum systems can generate entanglement starting from an uncorrelated state. Of special interest in quantum computing is the parity measurement, which projects a register of quantum bits (qubits) to a state with an even or odd total number of excitations. Crucially, a parity meter must discern the two parities with high fidelity while preserving coherence between same-parity states. Despite numerous proposals for atomic, semiconducting, and superconducting qubits, realizing a parity meter creating entanglement for both even and odd measurement results has remained an outstanding challenge. We realize a time-resolved, continuous parity measurement of two superconducting qubits using the cavity in a 3D circuit quantum electrodynamics (cQED) architecture and phase-sensitive parametric amplification. Using postselection, we produce entanglement by parity measurement reaching 77% concurrence. Incorporating the parity meter in a feedback-control loop, we transform the entanglement generation from probabilistic to fully deterministic, achieving 66% fidelity to a target Bell state on demand. These realizations of a parity meter and a feedback-enabled deterministic measurement protocol provide key ingredients for active quantum error correction in the solid state., Comment: 7 pages, 4 figures, and 9 supplementary figures
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- 2013
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26. Millisecond charge-parity fluctuations and induced decoherence in a superconducting qubit
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Ristè, D., Bultink, C. C., Tiggelman, M. J., Schouten, R. N., Lehnert, K. W., and DiCarlo, L.
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Superconductivity ,Quantum Physics - Abstract
Quasiparticle excitations adversely affect the performance of superconducting devices in a wide range of applications. They limit the sensitivity of photon detectors in astronomy, the accuracy of current sources in metrology, the cooling power of micro-refrigerators, and could break the topological protection of Majorana qubits. In superconducting circuits for quantum information processing, tunneling of quasiparticles across Josephson junctions constitutes a decoherence mechanism. As relaxation and pure dephasing times of transmon-type charge qubits now reach 100 microseconds, understanding whether quasiparticle tunneling may already bottleneck coherence is of high interest. We integrate recent advances in qubit readout and feedback control in circuit quantum electrodynamics to perform the first real-time observation of quasiparticle tunneling in a transmon qubit. We demonstrate quasiparticle-tunneling contributions to qubit relaxation and pure dephasing in the millisecond range. Thus, quasiparticle tunneling will not limit coherence for at least one order of magnitude beyond the state of the art., Comment: 5 pages, 4 figures, and Supplementary Information (5 figures)
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- 2012
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27. Selective darkening of degenerate transitions demonstrated with two superconducting quantum bits
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de Groot, P. C., Lisenfeld, J., Schouten, R. N., Ashhab, S., Lupascu, A., Harmans, C. J. P. M., and Mooij, J. E.
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Condensed Matter - Superconductivity - Abstract
Controlled manipulation of quantum states is central to studying natural and artificial quantum systems. If a quantum system consists of interacting sub-units, the nature of the coupling may lead to quantum levels with degenerate energy differences. This degeneracy makes frequency-selective quantum operations impossible. For the prominent group of transversely coupled two-level systems, i.e. qubits, we introduce a method to selectively suppress one transition of a degenerate pair while coherently exciting the other, effectively creating artificial selection rules. It requires driving two qubits simultaneously with the same frequency and specified relative amplitude and phase. We demonstrate our method on a pair of superconducting flux qubits. It can directly be applied to the other superconducting qubits, and to any other qubit type that allows for individual driving. Our results provide a single-pulse controlled-NOT gate for the class of transversely coupled qubits.
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- 2010
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28. Low-crosstalk bifurcation detectors for coupled flux qubits
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de Groot, P. C., van Loo, A. F., Lisenfeld, J., Schouten, R. N., Lupascu, A., Harmans, C. J. P. M., and Mooij, J. E.
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Condensed Matter - Superconductivity - Abstract
We present experimental results on the crosstalk between two AC-operated dispersive bifurcation detectors, implemented in a circuit for high-fidelity readout of two strongly coupled flux qubits. Both phase-dependent and phase-independent contributions to the crosstalk are analyzed. For proper tuning of the phase the measured crosstalk is 0.1 % and the correlation between the measurement outcomes is less than 0.05 %. These results show that bifurcative readout provides a reliable and generic approach for multi-partite correlation experiments., Comment: Copyright 2010 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters and may be found at http://link.aip.org/link/?apl/96/123508
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- 2010
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29. QND measurement of a superconducting qubit in the weakly projective regime
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Picot, T., Schouten, R., Harmans, C. J. P. M., and Mooij, J. E.
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Condensed Matter - Superconductivity ,Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
Quantum state detectors based on switching of hysteretic Josephson junctions biased close to their critical current are simple to use but have strong back-action. We show that the back-action of a DC-switching detector can be considerably reduced by limiting the switching voltage and using a fast cryogenic amplifier, such that a single readout can be completed within 25 ns at a repetition rate of 1 MHz without loss of contrast. Based on a sequence of two successive readouts we show that the measurement has a clear quantum non-demolition character, with a QND fidelity of 75 %., Comment: submitted to PRL
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- 2010
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30. Josephson squelch filter for quantum nanocircuits
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Forn-Diaz, P., Schouten, R. N., Braver, W. A. den, Mooij, J. E., and Harmans, C. J. P. M.
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Condensed Matter - Superconductivity - Abstract
We fabricated and tested a squelch circuit consisting of a copper powder filter with an embedded Josephson junction connected to ground. For small signals (squelch-ON), the small junction inductance attenuates strongly from DC to at least 1 GHz, while for higher frequencies dissipation in the copper powder increases the attenuation exponentially with frequency. For large signals (squelch-OFF) the circuit behaves as a regular metal powder filter. The measured ON/OFF ratio is larger than 50dB up to 50 MHz. This squelch can be applied in low temperature measurement and control circuitry for quantum nanostructures such as superconducting qubits and quantum dots., Comment: Corrected and completed references 6,7,8. Updated some minor details in figures
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- 2009
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31. P538 Platelet-rich stroma during surgery for treatment-refractory perianal fistulizing Crohn’s disease: long-term outcomes of a pilot study
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Bak, M, primary, Witjes, C, additional, Arkenbosch, J, additional, Dwarkasing, R, additional, van Dongen, J, additional, Fuhler, G, additional, Schouten, R, additional, van der Woude, J, additional, de Vries, A, additional, and van Ruler, O, additional
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- 2024
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32. Optimising primary molecular profiling in non-small cell lung cancer.
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Schouten, R. D., Schouten, I., Schuurbiers, M. M. F., van der Noort, V., Damhuis, R. A. M., van der Heijden, E. H. F. M., Burgers, J. A., Barlo, N. P., van Lindert, A. S. R., Maas, K. W., van den Brand, J. J. G., Smit, A. A. J., van Haarst, J. M. W., van der Maat, B., Schuuring, E., Blaauwgeers, H., Willems, S. M., Monkhorst, K., van den Broek, D., and van den Heuvel, M. M.
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NON-small-cell lung carcinoma , *SQUAMOUS cell carcinoma , *EPIDERMAL growth factor receptors , *TISSUE analysis , *RAS oncogenes - Abstract
Introduction: Molecular profiling of NSCLC is essential for optimising treatment decisions, but often incomplete. We assessed the efficacy of protocolised molecular profiling in the current standard-of-care (SoC) in a prospective observational study in the Netherlands and measured the effect of providing standardised diagnostic procedures. We also explored the potential of plasma-based molecular profiling in the primary diagnostic setting. Methods: This multi-centre prospective study was designed to explore the performance of current clinical practice during the run-in phase using local SoC tissue profiling procedures. The subsequent phase was designed to investigate the extent to which comprehensive molecular profiling (CMP) can be maximized by protocolising tumour profiling. Successful molecular profiling was defined as completion of at least EGFR and ALK testing. Additionally, PD-L1 tumour proportions scores were explored. Lastly, the additional value of centralised plasma-based testing for EGFR and KRAS mutations using droplet digital PCR was evaluated. Results: Total accrual was 878 patients, 22.0% had squamous cell carcinoma and 78.0% had non-squamous NSCLC. Stage I-III was seen in 54.0%, stage IV in 46.0%. Profiling of EGFR and ALK was performed in 69.9% of 136 patients included in the run-in phase, significantly more than real-world data estimates of 55% (p<0.001). Protocolised molecular profiling increased the rate to 77.0% (p = 0.049). EGFR and ALK profiling rates increased from 77.9% to 82.1% in non-squamous NSCLC and from 43.8% to 57.5% in squamous NSCLC. Plasma-based testing was feasible in 98.4% and identified oncogenic driver mutations in 7.1% of patients for whom tissue profiling was unfeasible. Conclusion: This study shows a high success rate of tissue-based molecular profiling that was significantly improved by a protocolised approach. Tissue-based profiling remains unfeasible for a substantial proportion of patients. Combined analysis of tumour tissue and circulating tumour DNA is a promising approach to allow adequate molecular profiling of more patients. [ABSTRACT FROM AUTHOR]
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- 2024
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33. A cryogenic amplifier for fast real-time detection of single-electron tunneling
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Vink, I. T., Nooitgedagt, T., Schouten, R. N., Wegscheider, W., and Vandersypen, L. M. K.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We employ a cryogenic High Electron Mobility Transistor (HEMT) amplifier to increase the bandwidth of a charge detection setup with a quantum point contact (QPC) charge sensor. The HEMT is operating at 1K and the circuit has a bandwidth of 1 MHz. The noise contribution of the HEMT at high frequencies is only a few times higher than that of the QPC shot noise. We use this setup to monitor single-electron tunneling to and from an adjacent quantum dot and we measure fluctuations in the dot occupation as short as 400 nanoseconds, 20 times faster than in previous work., Comment: 4 pages, 3 figures
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- 2007
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34. Low-frequency Noise in Josephson Junctions for Superconducting Qubits
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Eroms, J., van Schaarenburg, L. C., Driessen, E. F. C., Plantenberg, J. H., Huizinga, K., Schouten, R. N., Verbruggen, A. H., Harmans, C. J. P. M., and Mooij, J. E.
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Condensed Matter - Superconductivity - Abstract
We have studied low-frequency resistance fluctuations in shadow-evaporated Al/AlOx/Al tunnel junctions. Between 300 K and 5 K the spectral density follows a 1/f-law. Below 5 K, individual defects distort the 1/f-shape of the spectrum. The spectral density decreases linearly with temperature between 150 K and 1 K and saturates below 0.8 K. At 4.2 K, the spectral density is about two orders of magnitude lower than expected from a recent survey [D. J. Van Harlingen et al., Phys. Rev. B 70, 064510 (2004)]. Due to the saturation below 0.8 K the estimated qubit dephasing times at 100 mK are only about two times longer than calculated by Van Harlingen et al., Comment: Journal ref added, minor changes to match published version
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- 2006
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35. Real-time detection of single electron tunneling using a quantum point contact
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Vandersypen, L. M. K., Elzerman, J. M., Schouten, R. N., van Beveren, L. H. Willems, Hanson, R., and Kouwenhoven, L. P.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We observe individual tunnel events of a single electron between a quantum dot and a reservoir, using a nearby quantum point contact (QPC) as a charge meter. The QPC is capacitively coupled to the dot, and the QPC conductance changes by about 1% if the number of electrons on the dot changes by one. The QPC is voltage biased and the current is monitored with an IV-convertor at room temperature. We can resolve tunnel events separated by only 8 $\mu$s, limited by noise from the IV-convertor. Shot noise in the QPC sets a 25 ns lower bound on the accessible timescales., Comment: 3 pages, 3 figures, submitted
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- 2004
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36. Nondestructive readout for a superconducting flux qubit
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Lupascu, A., Verwijs, C. J. M., Schouten, R. N., Harmans, C. J. P. M., and Mooij, J. E.
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Condensed Matter - Superconductivity ,Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
We present a new readout method for a superconducting flux qubit, based on the measurement of the Josephson inductance of a superconducting quantum interference device that is inductively coupled to the qubit. The intrinsic flux detection efficiency and back-action are suitable for a fast and nondestructive determination of the quantum state of the qubit, as needed for readout of multiple qubits in a quantum computer. We performed spectroscopy of a flux qubit and we measured relaxation times of the order of 80 $\mu s$., Comment: 4 pages, 4 figures; modified content, figures and references; accepted for publication in Phys. Rev. Lett
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- 2003
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37. Simulating fruit growth and size analysis
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Tijskens, P., primary, Schouten, R., additional, McCormick, R., additional, Unuk, T., additional, and Cavaco, A.M., additional
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- 2023
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38. Quantum Superposition of Macroscopic Persistent-Current States
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van der Wal, Caspar H., Wilhelm, F. K., Schouten, R. N., Orlando, T. P., Lloyd, Seth, and Mooij, J. E.
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- 2000
39. Revision of the genus Metaeuchromius Bleszynski (Lepidoptera: Pyralidae: Crambinae)
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Schouten, R T A and BioStor
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- 1997
40. Revision of the genera Euchromius Guenée and Miyakea Marumo (Lepidoptera: Crambidae: Crambinae)
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Schouten, R T A and BioStor
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- 1992
41. Simulating fruit growth and size analysis
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Tijskens, P., Schouten, R., McCormick, R., Unuk, T., Cavaco, A.M., Tijskens, P., Schouten, R., McCormick, R., Unuk, T., and Cavaco, A.M.
- Abstract
Growth of fruit and fruit size is of major importance for growers. Growth in size during cell expansion is well known (adapted van Bertalanffy model) and well applied taking care of the ever-present variation. Explained parts reach well over 98%. What is not very well understood is the increase in number of cells and the associated size increase, just after fruit set. It is (for the time being) just not feasible to measure these small fruit (<5 mm) on an individual level. As a consequence, the von Bertalanffy model does not cover the behaviour right after fruit set. Very rare reports, however, indicate a gradual increase in number of cells, which keep subsequently growing in size during the cell expansion period. A kinetic mechanism is presented that includes both these concurrent processes, however, consisting of six reactions, this model becomes exceedingly complex. Hence, an analytical solution is not available. Simulation using numerical integration with various parameter values will be presented. The general behaviour is as expected, roughly as an asymmetric sigmoidal. As a comparison, the well know Richards’ curve, frequently used to describe growth, is hard to apply as an analysing tool. Moreover, this function has no relation whatsoever with any kinetic mechanism. A new simplified kinetic mechanism that is suitable for data analysis is presented based on conversion of a substrate by an enzyme that increases according to an autocatalytic reaction. The resulting analytical solution can be used to analyse simulated size data, including biological variation. All simulated data on growth size fitted extremely well in the asymmetrical logistic model, with explained parts well over 99%. Behaviour of the growth mechanism, and analysis results of simulated data the developed asymmetrical sigmoidal function will be presented and discussed.
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- 2023
42. Mechanistic forecasts of species responses to climate change: The promise of biophysical ecology
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Briscoe, NJ, Morris, SD, Mathewson, PD, Buckley, LB, Jusup, M, Levy, O, Maclean, IMD, Pincebourde, S, Riddell, EA, Roberts, JA, Schouten, R, Sears, MW, Kearney, MR, Briscoe, NJ, Morris, SD, Mathewson, PD, Buckley, LB, Jusup, M, Levy, O, Maclean, IMD, Pincebourde, S, Riddell, EA, Roberts, JA, Schouten, R, Sears, MW, and Kearney, MR
- Abstract
A core challenge in global change biology is to predict how species will respond to future environmental change and to manage these responses. To make such predictions and management actions robust to novel futures, we need to accurately characterize how organisms experience their environments and the biological mechanisms by which they respond. All organisms are thermodynamically connected to their environments through the exchange of heat and water at fine spatial and temporal scales and this exchange can be captured with biophysical models. Although mechanistic models based on biophysical ecology have a long history of development and application, their use in global change biology remains limited despite their enormous promise and increasingly accessible software. We contend that greater understanding and training in the theory and methods of biophysical ecology is vital to expand their application. Our review shows how biophysical models can be implemented to understand and predict climate change impacts on species' behavior, phenology, survival, distribution, and abundance. It also illustrates the types of outputs that can be generated, and the data inputs required for different implementations. Examples range from simple calculations of body temperature at a particular site and time, to more complex analyses of species' distribution limits based on projected energy and water balances, accounting for behavior and phenology. We outline challenges that currently limit the widespread application of biophysical models relating to data availability, training, and the lack of common software ecosystems. We also discuss progress and future developments that could allow these models to be applied to many species across large spatial extents and timeframes. Finally, we highlight how biophysical models are uniquely suited to solve global change biology problems that involve predicting and interpreting responses to environmental variability and extremes, multiple or shif
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- 2023
43. The Netherlands Heart Tissue Bank:Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository
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Henkens, M. T.H.M., van Ast, J. F., te Riele, A. S.J.M., Houweling, A. C., Amin, A. S., Nijveldt, R., Antoni, M. L., Li, X., Wehrens, S. M.T., von der Thüsen, J. H., Damman, K., ter Horst, E. N., Manintveld, O. C., Abma-Schouten, R. Y., Niessen, H. W.M., Silljé, H. H.W., Jukema, J. W., Doevendans, P. A., Henkens, M. T.H.M., van Ast, J. F., te Riele, A. S.J.M., Houweling, A. C., Amin, A. S., Nijveldt, R., Antoni, M. L., Li, X., Wehrens, S. M.T., von der Thüsen, J. H., Damman, K., ter Horst, E. N., Manintveld, O. C., Abma-Schouten, R. Y., Niessen, H. W.M., Silljé, H. H.W., Jukema, J. W., and Doevendans, P. A.
- Abstract
Aim: Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This design paper describes the initiative of the Netherlands Heart Tissue Bank (NHTB) that aims to boost CVD-related research by providing an open-access biobank. Methods: The NHTB, founded in June 2020, is a non-profit biobank that collects and stores biomaterial (including but not limited to myocardial tissue and blood samples) and clinical data of individuals with and without previously known cardiac diseases. All individuals aged ≥ 18 years living in the Netherlands are eligible for inclusion as a potential future donor. The stored samples and clinical data will be available upon request for cardiovascular researchers. Conclusion: To improve the availability of cardiac tissue for cardiovascular research, the NHTB will include extensive (cardiac) biosamples, medical images, and clinical data of donors with and without a previously known cardiac disease. As such, the NHTB will function as a translational bridge to boost a wide range of cardiac disease-related fundamental and translational studies.
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- 2023
44. The Netherlands Heart Tissue Bank: Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository
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Henkens, M T H M, van Ast, J F, Te Riele, A S J M, Houweling, A C, Amin, A S, Nijveldt, R, Antoni, M L, Li, X, Wehrens, S M T, von der Thüsen, J H, Damman, K, Ter Horst, E N, Manintveld, O C, Abma-Schouten, R Y, Niessen, H W M, Silljé, H H W, Jukema, J W, Doevendans, P A, Henkens, M T H M, van Ast, J F, Te Riele, A S J M, Houweling, A C, Amin, A S, Nijveldt, R, Antoni, M L, Li, X, Wehrens, S M T, von der Thüsen, J H, Damman, K, Ter Horst, E N, Manintveld, O C, Abma-Schouten, R Y, Niessen, H W M, Silljé, H H W, Jukema, J W, and Doevendans, P A
- Abstract
AIM: Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This design paper describes the initiative of the Netherlands Heart Tissue Bank (NHTB) that aims to boost CVD-related research by providing an open-access biobank.METHODS: The NHTB, founded in June 2020, is a non-profit biobank that collects and stores biomaterial (including but not limited to myocardial tissue and blood samples) and clinical data of individuals with and without previously known cardiac diseases. All individuals aged ≥ 18 years living in the Netherlands are eligible for inclusion as a potential future donor. The stored samples and clinical data will be available upon request for cardiovascular researchers.CONCLUSION: To improve the availability of cardiac tissue for cardiovascular research, the NHTB will include extensive (cardiac) biosamples, medical images, and clinical data of donors with and without a previously known cardiac disease. As such, the NHTB will function as a translational bridge to boost a wide range of cardiac disease-related fundamental and translational studies.
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- 2023
45. The Netherlands Heart Tissue Bank: Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository
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Circulatory Health, Onderzoek Precision medicine, Cardiologie zorg, Team Medisch, Regenerative Medicine and Stem Cells, Henkens, M.T.H.M., van Ast, J. F., te Riele, A.S.J.M., Houweling, A. C., Amin, A. S., Nijveldt, R., Antoni, M. L., Li, X., Wehrens, S. M.T., von der Thüsen, J. H., Damman, K., ter Horst, E. N., Manintveld, O. C., Abma-Schouten, R. Y., Niessen, H. W.M., Silljé, H. H.W., Jukema, J. W., Doevendans, P. A., Circulatory Health, Onderzoek Precision medicine, Cardiologie zorg, Team Medisch, Regenerative Medicine and Stem Cells, Henkens, M.T.H.M., van Ast, J. F., te Riele, A.S.J.M., Houweling, A. C., Amin, A. S., Nijveldt, R., Antoni, M. L., Li, X., Wehrens, S. M.T., von der Thüsen, J. H., Damman, K., ter Horst, E. N., Manintveld, O. C., Abma-Schouten, R. Y., Niessen, H. W.M., Silljé, H. H.W., Jukema, J. W., and Doevendans, P. A.
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- 2023
46. Long-term mid-facial growth of patients with a unilateral complete cleft of lip, alveolus and palate treated by two-stage palatoplasty: cephalometric analysis
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Kappen, I. F. P. M., Bittermann, G. K. P., Schouten, R. M., Bittermann, D., Etty, E., Koole, R., Kon, M., Mink van der Molen, A. B., and Breugem, C. C.
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- 2017
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47. Il medico e la violenza sul posto di lavoro
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Schouten, R., Simon, Robert I., and Tardiff, Kenneth
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- 2014
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48. 27 Bariatrische en metabole chirurgie
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Schouten, R., Greve, J.W., Gooszen, H.G., editor, Blankensteijn, J.D., editor, Borel Rinkes, I.H.M., editor, Dejong, C.H.C., editor, Gouma, D.J., editor, Heineman, E., editor, Lange, J.F., editor, and Schipper, I.B., editor
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- 2012
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49. Oncological Safety and Potential Cost Savings of Routine vs Selective Histopathological Examination After Appendectomy Results of the Multicenter, Prospective, Cross-Sectional FANCY Study
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Bastiaenen, Vivian P., de Jonge, Joske, Corten, Bartholomeus J. G. A., de Savornin Lohman, Elise A. J., Kraima, Anne C., Swank, Hilko A., van Vliet, Jaap L. P., van Acker, Gijs J. D., van Geloven, Anna A. W., in'tHof, Klaas H., Koens, Lianne, de Reuver, Philip R., van Rossem, Charles C., Slooter, Gerrit D., Tanis, Pieter J., Terpstra, Valeska, Dijkgraaf, Marcel G. W., Bemelman, Willem A., Amelung, F. J., Atema, J. J., Bessems, S., Beunders, A. A. M., Bodewes, T. C. F., den Boer, F. C., Boerma, D., Boerma, E. G., van den Boezem, P., Bökkerink, W. J. V., van den Boogaart, D., Boogerd, L. S. F., Bouwman, H., Broos, A., Brueren, L. O., Bruinsma, W. E., Bruns, E. R. C., Castelijns, P. S. S., de Castro, S. M. M., Consten, E. C. J., Crolla, R. M. P. H., Dam, M. J., Dang, Q., Dekker, J. W. T., Deroose, J. P., Devriendt, S., Dijkema, E. J., Dijkstra, N., Driessen, M. L. S., van Duijvendijk, P., Duinhouwer, L. E., van Duyn, E. B., el-Massoudi, Y., Elfrink, A. K. E., Elschot, J. H., van Essen, J. A., Ferenschild, F. T. J., Gans, S. L., Gaznay, C., Geraedts, A. C. M., van Gessel, B. S. H., Giesen, L. J. X., van Gils, N., Gorgec, B., Gorter, R. R., Govaert, K. M., Greuter, G. N., van Grevenstein, W. M. U., Groot, L., Hardy, J. C. A., Heemskerk, J., Heeren, J. F., Heidotting, J., Heikens, J. T., Hosseinzoi, E., van Iersel, J. J., Inberg, B., Jansen, L. J., Jens, A. J. T., Jilesen, A. P. J., Joosten, M., de Jong, L., Keijzers, M., Klicks, R. J., Kloppenberg, F. W. H., Koedam, T. W. A., Koëter, T., Konsten, J. L. M., Koolen, L. J. E. R., Kruyt, Ph. M., Lange, J. F. M., Lavrijssen, B. D. A., de Leede, E. M., Leliefeld, P. H. C., Linnemann, R. J. A., Lo, G. C., van de Loo, M., Lubbert, P. H. W., Holzik, M. F. Lutke, Manusama, E., Masselink, I., Matthée, E. P. C., Matthijsen, R. A., Mearadji, A., Melenhorst, J., Merkus, J. W. S., Michiels, T. D., Moes, D. E., Moossdorff, M., Mulder, E., Nallayici, E. G., Neijenhuis, P. A., Nielsen, K., Nieuwenhuijzen, G. A. P., Nijhuis, J., Okkema, S., Olthof, P. B., van Onkelen, R. S., van Oostendorp, S. E., Plaisier, P. W., Polle, S. W., Reiber, B. M. M., Reichert, F. C. M., van Rest, K. L. C., van Rijn, R., Roozendaal, N. C., de Ruijter, W. M. J., Schat, E., Scheerhoorn, J., Scheijmans, J. C. G., Schimmer, J., Schipper, R. J., Schouten, R., Schreurs, W. H., Schrijver, W. A. M. E., Shapiro, J., Siemons, A., Silvis, R., Simkens, G. A., Smakman, N., Smeets, B. J. J., Sonneveld, D. J. A., van Suijlichem, M., Talsma, A. K., Thoolen, J. M. M., van Tol, R. R., Tournoij, E., Tseng, L. N. L., Tuynman, J. B., van der Velde, K., Veltkamp, S. C., Verbeek, F. P. R., Verdaasdonk, E., Verhaak, T., Verheuvel, N. C., Vermaas, M., Verseveld, M., Vlek, S., Vogels, S., van de Voort, E. M. F., van Vugt, S. T., Wegdam, J. A., Wennekers, M. M., Wiering, B., de Wijkerslooth, E. M. L., Wijkmans, A. A., Wijnhoven, B. P. L., Witjes, C. D. M., Wolfhagen, N., de Zeeuw, S., van Zoonen, G., Surgery, Erasmus MC other, Obstetrics & Gynecology, Department of Strategic Management and Entrepreneurship, Neurology, Rotterdam School of Management, Cardiology, Gastroenterology & Hepatology, Radiology & Nuclear Medicine, Otorhinolaryngology and Head and Neck Surgery, Emergency Medicine, Public Health, Plastic and Reconstructive Surgery and Hand Surgery, Dermatology, Clinical Chemistry, Internal Medicine, Erasmus School of Social and Behavioural Sciences, General Practice, Radiotherapy, Research & Education, Rehabilitation Medicine, Urology, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, Hematology laboratory, VU University medical center, CCA - Cancer Treatment and quality of life, and CCA - Imaging and biomarkers
- Subjects
medicine.medical_specialty ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,All institutes and research themes of the Radboud University Medical Center ,business.industry ,General surgery ,Medicine ,Surgery ,Histopathological examination ,business ,Cost savings - Abstract
Objective: To investigate the oncological safety and potential cost savings of selective histopathological examination after appendectomy. Background: The necessity of routine histopathological examination after appendectomy has been questioned, but prospective studies investigating the safety of a selective policy are lacking. Methods: In this multicenter, prospective, cross-sectional study, inspection and palpation of the (meso)appendix was performed by the surgeon in patients with suspected appendicitis. The surgeon's opinion on additional value of histopathological examination was reported before sending all specimens to the pathologist. Main outcomes were the number of hypothetically missed appendiceal neoplasms with clinical consequences benefiting the patient (upper limit two-sided 95% confidence interval below 3:1000 considered oncologically safe) and potential cost savings after selective histopathological examination. Results: Seven thousand three hundred thirty-nine patients were included. After a selective policy, 4966/7339 (67.7%) specimens would have been refrained from histopathological examination. Appendiceal neoplasms with clinical consequences would have been missed in 22/4966 patients. In 5/22, residual disease was completely resected during additional surgery. Hence, an appendiceal neoplasm with clinical consequences benefiting the patient would have been missed in 1.01:1000 patients (upper limit 95% confidence interval 1.61:1000). In contrast, twice as many patients (10/22) would not have been exposed to potential harm due to re-resections without clear benefit, whereas consequences were neither beneficial nor harmful in the remaining seven. Estimated cost savings established by replacing routine for selective histopathological examination were 725,400 per 10,000 patients. Conclusions: Selective histopathological examination after appendectomy for suspected appendicitis is oncologically safe and will likely result in a reduction of pathologists' workload, less costs, and fewer re-resections without clear benefit.
- Published
- 2023
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50. A new species of Euchromius Guenée, 1845 (Lepidoptera: Pyralidae: Crambinae) from Australia
- Author
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Schouten, R T A and BioStor
- Published
- 1990
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