118 results on '"Schouten, Jeoffrey"'
Search Results
2. THU-123-YI External validation of the international autoimmune hepatitis group response criteria in a multicentric real-world cohort
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Grossar, Lorenz, primary, Raevens, Sarah, additional, Van Steenkiste, Christophe, additional, Colle, Isabelle, additional, De Vloo, Charlotte, additional, Orlent, Hans, additional, Schouten, Jeoffrey, additional, Gallant, Marie, additional, Van Driessche, Annelien, additional, Lefere, Sander, additional, Devisscher, Lindsey, additional, Geerts, Anja, additional, Van Vlierberghe, Hans, additional, and Verhelst, Xavier, additional
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- 2024
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3. THU-412 Hepatitis C lost to follow-up rates in primary care practices in Belgium
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Coessens, Marie, primary, Schouten, Jeoffrey, additional, and Verlinden, Wim, additional
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- 2024
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4. Aminotransferases During Treatment Predict Long-Term Survival in Patients With Autoimmune Hepatitis Type 1: A Landmark Analysis
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Bouma, G., de Boer, Y., Drenth, J.P.H., van Gerven, N.M., Beuers, U., van Erpecum, K.J., den Ouden, J.W., Bhalla, A., Brouwer, J.T., Vrolijk, J.M., Koek, G.H., Guichelaar, M.M.J., van der Wouden, E.J., van Meyel, J.J.M., Baak, L.C., Verdonk, R.C., Klemt-Kropp, M., Verhagen, M.A.M.T., Kuijvenhoven, J.Ph., de Jonge, H.M., Biewenga, Maaike, Verhelst, Xavier, Baven-Pronk, Martine, Putter, Hein, van den Berg, Aad, Colle, Isabelle, Schouten, Jeoffrey, Sermon, Filip, Van Steenkiste, Christophe, van Vlierberghe, Hans, van der Meer, Adriaan, and van Hoek, Bart
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- 2022
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5. Awareness of chronic hepatitis B and C in men who have sex with men in Belgium: epidemiological survey and on-site screening.
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Coessens, Marie, Schouten, Jeoffrey, Holvoet, Tom, and Verlinden, Wim
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- 2024
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6. Prothrombotic genetic risk factors are associated with an increased risk of liver fibrosis in the general population: The Rotterdam Study
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Plompen, Elisabeth P.C., Darwish Murad, Sarwa, Hansen, Bettina E., Loth, Daan W., Schouten, Jeoffrey N.L., Taimr, Pavel, Hofman, Albert, Uitterlinden, André G., Stricker, Bruno H., Janssen, Harry L.A., and Leebeek, Frank W.G.
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- 2015
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7. Aminotransferases During Treatment Predict Long-Term Survival in Patients With Autoimmune Hepatitis Type 1: A Landmark Analysis
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Biewenga, Maaike, primary, Verhelst, Xavier, additional, Baven-Pronk, Martine, additional, Putter, Hein, additional, van den Berg, Aad, additional, Colle, Isabelle, additional, Schouten, Jeoffrey, additional, Sermon, Filip, additional, Van Steenkiste, Christophe, additional, van Vlierberghe, Hans, additional, van der Meer, Adriaan, additional, van Hoek, Bart, additional, Bouma, G., additional, de Boer, Y., additional, Drenth, J.P.H., additional, van Gerven, N.M., additional, Beuers, U., additional, van Erpecum, K.J., additional, den Ouden, J.W., additional, Bhalla, A., additional, Brouwer, J.T., additional, Vrolijk, J.M., additional, Koek, G.H., additional, Guichelaar, M.M.J., additional, van der Wouden, E.J., additional, van Meyel, J.J.M., additional, Baak, L.C., additional, Verdonk, R.C., additional, Klemt-Kropp, M., additional, Verhagen, M.A.M.T., additional, Kuijvenhoven, J.Ph., additional, and de Jonge, H.M., additional
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- 2022
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8. Awareness of chronic hepatitis B and C among men who have sex with men (MSM): epidemiological survey and on-site screening
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Coessens, Marie, primary, Holvoet, Tom, additional, Schouten, Jeoffrey, additional, and Verlinden, Wim, additional
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- 2022
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9. Statin therapy is associated with a reduced risk of non-alcoholic fatty liver in overweight individuals
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de Keyser, Catherine E., Koehler, Edith M., Schouten, Jeoffrey N.L., Visser, Loes E., Hofman, Albert, Janssen, Harry L.A., and Stricker, Bruno H.
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- 2014
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10. Multiple biopsy passes and the risk of complications of percutaneous liver biopsy
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Chi, Heng, Hansen, Bettina E., Tang, Wing Yin, Schouten, Jeoffrey N.L., Sprengers, Dave, Taimr, Pavel, Janssen, Harry L.A., and de Knegt, Robert J.
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- 2017
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11. Presence of Diabetes Mellitus and Steatosis Is Associated With Liver Stiffness in A General Population: The Rotterdam Study
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Koehler, Edith M., Plompen, Elisabeth P.C., Schouten, Jeoffrey N.L., Hansen, Bettina E., Darwish Murad, Sarwa, Taimr, Pavel, Leebeek, Frank W.G., Hofman, Albert, Stricker, Bruno H., Castera, Laurent, and Janssen, Harry L.A.
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- 2016
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12. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in the general population: the Rotterdam Study
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Plompen, Elisabeth P C, Hansen, Bettina E, Schouten, Jeoffrey N L, Murad, Sarwa Darwish, Loth, Daan W, Brouwer, Willem Pieter, Isaacs, Aaron, Taimr, Pavel, Hofman, Albert, van Duijn, Cornelia M, Uitterlinden, André G, Stricker, Bruno H C, Leebeek, Frank W G, and Janssen, Harry L A
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- 2015
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13. Development and validation of a prognostic score for long-term transplant-free survival in autoimmune hepatitis type 1
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Biewenga, Maaike, Verhelst, Xavier P. D. M. J., Baven-Pronk, Martine A. M. C., Putter, Hein, van den Berg, Aad P., van Nieuwkerk, Karin C. M. J., van Buuren, Henk R., Bouma, Gerd, de Boer, Ynte S., Simoen, Cedric, Colle, Isabelle, Schouten, Jeoffrey, Sermon, Filip, van Steenkiste, Christophe, van Vlierberghe, Hans, van der Meer, Adriaan J., Nevens, Frederik, van Hoek, Bart, Drenth, J. P. H., van Gerven, N. M., Beuers, U., van Erpecum, K. J., den Ouden, J. W., Bhalla, A., Brouwer, J. T., Vrolijk, J. M., Koek, G. H., Guichelaar, M. M. J., van der Wouden, E. J., van Meyel, J. J. M., Baak, L. C., Verdonk, R. C., Klemt-Kropp, M., Verhagen, M. A. M. T., Kuijvenhoven, J., de Jonge, H. M., Amsterdam Gastroenterology Endocrinology Metabolism, AII - Inflammatory diseases, Gastroenterology and hepatology, Gastroenterology & Hepatology, Groningen Institute for Organ Transplantation (GIOT), Dutch Autoimmune Hepatitis Study Group, Neurosurgery, ANS - Neurovascular Disorders, Gastroenterology and Hepatology, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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Liver Cirrhosis ,Male ,Cirrhosis ,Time Factors ,IMPACT ,medicine.medical_treatment ,Autoimmune hepatitis ,risk stratification ,Liver transplantation ,Gastroenterology ,THERAPY ,DISEASE ,Cohort Studies ,Belgium ,AIH ,Interquartile range ,Risk Factors ,Medicine and Health Sciences ,Child ,CIRRHOSIS ,transplant‐free survival ,Netherlands ,risk ,Aged, 80 and over ,validation ,OUTCOMES ,liver transplantation ,Hazard ratio ,autoimmune liver disease ,Middle Aged ,Prognosis ,prognostic score ,Hepatitis, Autoimmune ,Oncology ,Child, Preschool ,Cohort ,Disease Progression ,Original Article ,Female ,TRIAL ,Life Sciences & Biomedicine ,long-term survival ,Adult ,medicine.medical_specialty ,Adolescent ,long‐term survival ,liver ,Risk Assessment ,Disease-Free Survival ,Decision Support Techniques ,Young Adult ,stratification ,SDG 3 - Good Health and Well-being ,Internal medicine ,medicine ,Humans ,Aged ,Proportional Hazards Models ,Science & Technology ,Gastroenterology & Hepatology ,autoimmune hepatitis ,business.industry ,Proportional hazards model ,Reproducibility of Results ,NATURAL-HISTORY ,REMISSION ,medicine.disease ,mortality ,transplant-free survival ,Transplantation ,Multivariate Analysis ,Human medicine ,Hepatobiliary ,business ,transplantation - Abstract
BACKGROUND: No prognostic score is currently available for long-term survival in autoimmune hepatitis (AIH) patients. OBJECTIVE: The aim of this study was to develop and validate such a prognostic score for AIH patients at diagnosis. METHODS: The prognostic score was developed using uni- & multivariate Cox regression in a 4-center Dutch cohort and validated in an independent 6-center Belgian cohort. RESULTS: In the derivation cohort of 396 patients 19 liver transplantations (LTs) and 51 deaths occurred (median follow-up 118 months; interquartile range 60-202 months). In multivariate analysis age (hazard ratio [HR] 1.045; p
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- 2021
14. Increased liver stiffness is associated with higher all-cause mortality in older adults: results from a population-based study: 14
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Koehler, Edith M., Plompen, Elisabeth P., Schouten, Jeoffrey, Hansen, Bet-tina E., van Rooij, Frank J., Taimr, Pavel, Heeringa, Jan, Hofman, Albert, Stricker, Bruno H., Murad, Sarwa Darwish, Castera, Laurent, and Janssen, Harry L.
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- 2014
15. Factors Associated with and Prevalence of Liver Fibrosis in a General Elderly Population: Results from the Rotterdam Study: 13
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Plompen, Elisabeth P., Koehler, Edith M., Schouten, Jeoffrey, Hansen, Bettina E., Taimr, Pavel, Hofman, Albert, Leebeek, Frank W., Murad, Sarwa Darwish, Stricker, Bruno H., Castera, Laurent, and Janssen, Harry L.
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- 2014
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16. Role of anticoagulant therapy in liver disease
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Plompen, Elisabeth P. C., Schouten, Jeoffrey N. L., and Janssen, Harry L. A.
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- 2013
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17. Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years old or older: Results from a population-based study
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van der Voort, Ella A.M., Koehler, Edith M., Dowlatshahi, Emmilia A., Hofman, Albert, Stricker, Bruno H., Janssen, Harry L.A., Schouten, Jeoffrey N.L., and Nijsten, Tamar
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- 2014
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18. Serum liver enzymes are associated with all-cause mortality in an elderly population
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Koehler, Edith M., Sanna, Donatella, Hansen, Bettina E., van Rooij, Frank J., Heeringa, Jan, Hofman, Albert, Tiemeier, Henning, Stricker, Bruno H., Schouten, Jeoffrey N. L., and Janssen, Harry L. A.
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- 2014
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19. External Validation of the Fatty Liver Index for Identifying Nonalcoholic Fatty Liver Disease in a Population-based Study
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Koehler, Edith M., Schouten, Jeoffrey N.L., Hansen, Bettina E., Hofman, Albert, Stricker, Bruno H., and Janssen, Harry L.A.
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- 2013
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20. Histological features in western patients with idiopathic non-cirrhotic portal hypertension
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Verheij, Joanne, Schouten, Jeoffrey N L, Komuta, Mina, Nevens, Frederik, Hansen, Bettina E, Janssen, Harry L A, and Roskams, Tania
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- 2013
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21. Predictors of Nonalcoholic Fatty Liver Disease in nondiabetic lean elderly individuals: 1498
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Koehler, Edith M., Schouten, Jeoffrey N., Hansen, Bettina E., Stricker, Bruno H., and Janssen, Harry L.
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- 2012
22. HIV-associated Idiopathic Noncirrhotic Portal Hypertension: Risk factors And Association With Didanosine: 1179
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Schouten, Jeoffrey N., Van der Ende, Marchina E., Taimr, Pavel, de Knegt, Robert J., Koëter, Tijmen, Rossing, Henderikus H., Hansen, Bettina E., and Janssen, Harry L.
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- 2012
23. Association between statin use and Nonalcoholic Fatty Liver Disease in a population-based study: 825
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Koehler, Edith M., de Keyser, Catherine E., Schouten, Jeoffrey N., Hansen, Bettina E., Janssen, Harry L., and Stricker, Bruno H.
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- 2012
24. Porto-sinusoidal vascular disease: proposal and description of a novel entity
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De Gottardi, Andrea, Rautou, Pierre-Emmanuel, Schouten, Jeoffrey, Rubbia-Brandt, Laura, Leebeek, Frank, Trebicka, Jonel, Murad, Sarwa Darwish, Vilgrain, Valérie, Hernandez-Gea, Virginia, Nery, Filipe, Plessier, Aurélie, Berzigotti, Annalisa, Bioulac-Sage, Paulette, Primignani, Massimo, Semela, David, Elkrief, Laure, Bedossa, Pierre, Valla, Dominique, and Garcia-Pagan, Juan Carlos
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- 2019
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25. Idiopathic noncirrhotic portal hypertension
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Schouten, Jeoffrey N.L., Garcia-Pagan, Juan C., Valla, Dominique C., and Janssen, Harry L.A.
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- 2011
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26. Development and validation of a novel risk score predicting long-term survival in autoimmune hepatitis
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Biewenga, Maaike, primary, Xavier, Verhelst, additional, Baven-Pronk, Martine, additional, Putter, Hein, additional, van den Berg, Aad, additional, van Nieuwkerk, Karin, additional, Van Buuren, Henk, additional, Bouma, Gerd, additional, de Boer, Ynte, additional, Simoen, Cedric, additional, Colle, Isabelle, additional, Schouten, Jeoffrey, additional, Sermon, Filip, additional, Van Steenkiste, Christophe, additional, Van Vlierberghe, Hans, additional, Van der Meer, Adriaan, additional, Nevens, Frederik, additional, and Van Hoek, Bart, additional
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- 2020
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27. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
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Younossi, Zobair M, primary, Ratziu, Vlad, additional, Loomba, Rohit, additional, Rinella, Mary, additional, Anstee, Quentin M, additional, Goodman, Zachary, additional, Bedossa, Pierre, additional, Geier, Andreas, additional, Beckebaum, Susanne, additional, Newsome, Philip N, additional, Sheridan, David, additional, Sheikh, Muhammad Y, additional, Trotter, James, additional, Knapple, Whitfield, additional, Lawitz, Eric, additional, Abdelmalek, Manal F, additional, Kowdley, Kris V, additional, Montano-Loza, Aldo J, additional, Boursier, Jerome, additional, Mathurin, Philippe, additional, Bugianesi, Elisabetta, additional, Mazzella, Giuseppe, additional, Olveira, Antonio, additional, Cortez-Pinto, Helena, additional, Graupera, Isabel, additional, Orr, David, additional, Gluud, Lise Lotte, additional, Dufour, Jean-Francois, additional, Shapiro, David, additional, Campagna, Jason, additional, Zaru, Luna, additional, MacConell, Leigh, additional, Shringarpure, Reshma, additional, Harrison, Stephen, additional, Sanyal, Arun J, additional, Abdelmalek, Manal, additional, Abrams, Gary, additional, Aguilar, Humberto, additional, Ahmed, Aijaz, additional, Aigner, Elmar, additional, Aithal, Guruprasad, additional, Ala, Aftab, additional, Alazawi, William, additional, Albillos, Agustin, additional, Allison, Michael, additional, Al-Shamma, Sfa, additional, Andrade, Raul, additional, Andreone, Pietro, additional, Angelico, Mario, additional, Ankoma-Sey, Victor, additional, Anstee, Quentin, additional, Anty, Rodolphe, additional, Araya, Victor, additional, Arenas Ruiz, Juan Ignacio, additional, Arkkila, Perttu, additional, Arora, Marty, additional, Asselah, Tarik, additional, Au, Jennifer, additional, Ayonrinde, Oyekoya, additional, Bailey, Robert James, additional, Balakrishnan, Maya, additional, Bambha, Kiran, additional, Bansal, Meena, additional, Barritt, Sidney, additional, Bate, John, additional, Beato, Jorge, additional, Behari, Jaideep, additional, Bellot, Pablo, additional, Ben Ari, Ziv, additional, Bennett, Michael, additional, Berenguer, Marina, additional, Beretta-Piccoli, Benedetta Terziroli, additional, Berg, Thomas, additional, Bonacini, Maurizio, additional, Bonet, Lucia, additional, Borg, Brian, additional, Bourliere, Marc, additional, Bowman, William, additional, Bradley, David, additional, Brankovic, Marija, additional, Braun, Marius, additional, Bronowicki, Jean-Pierre, additional, Bruno, Savino, additional, Cai, Cindy, additional, Calderon, Amy, additional, Calleja Panero, José Luis, additional, Carey, Elizabeth, additional, Carmiel, Michal, additional, Carrión, Jose Antonio, additional, Cave, Matthew, additional, Chagas, Cristina, additional, Chami, Tawfik, additional, Chang, Alan, additional, Coates, Allan, additional, Cobbold, Jeremy, additional, Costentin, Charlote, additional, Corey, Kathleen, additional, Corless, Lynsey, additional, Crespo, Javier, additional, Cruz Pereira, Oscar, additional, de Ledinghen, Victor, additional, deLemos, Andrew, additional, Diago, Moises, additional, Dong, Mamie, additional, Dufour, Jean-François, additional, Dugalic, Predrag, additional, Dunn, Winston, additional, Elkhashab, Magby, additional, Epstein, Michael, additional, Escudero-Garcia, Maria Desamparados, additional, Etzion, Ohad, additional, Evans, Larry, additional, Falcone, Robert, additional, Fernandez, Conrado, additional, Ferreira, Jose, additional, Fink, Scott, additional, Finnegan, Kevin, additional, Firpi-Morell, Roberto, additional, Floreani, Annarosa, additional, Fontanges, Thierry, additional, Ford, Ryan, additional, Forrest, Ewan, additional, Fowell, Andrew, additional, Fracanzani, Anna Ludovica, additional, Francque, Sven, additional, Freilich, Bradley, additional, Frias, Juan, additional, Fuchs, Michael, additional, Fuentes, Javier, additional, Galambos, Michael, additional, Gallegos, Juan, additional, Geerts, Anja, additional, George, Jacob, additional, Ghali, Maged, additional, Ghalib, Reem, additional, Gholam, Pierre, additional, Gines, Pere, additional, Gitlin, Norman, additional, Goeser, Tobias, additional, Goff, John, additional, Gordon, Stuart, additional, Gordon, Frederic, additional, Goria, Odile, additional, Greer, Shaun, additional, Grigorian, Alla, additional, Gronbaek, Henning, additional, Guillaume, Maeva, additional, Gunaratnam, Naresh, additional, Halegoua-De Marzio, Dina, additional, Hameed, Bilal, additional, Hametner, Stephanie, additional, Hamilton, James, additional, Hartleb, Marek, additional, Hassanein, Tarek, additional, Häussinger, Dieter, additional, Hellstern, Paul, additional, Herring, Robert, additional, Heurich, Eva, additional, Hezode, Christophe, additional, Hinrichsen, Holger, additional, Holland Fischer, Peter, additional, Horsmans, Yves, additional, Huang, Jonathan, additional, Hussaini, Hyder, additional, Jakiche, Antoine, additional, Jeffers, Lennox, additional, Jones, Blake, additional, Jorge, Rosa, additional, Jorquera, Francisco, additional, Joshi, Shoba, additional, Kahraman, Alisan, additional, Kaita, Kelly, additional, Karyotakis, Nicholas, additional, Kayali, Zeid, additional, Kechagias, Stergios, additional, Kepczyk, Thomas, additional, Khalili, Mandana, additional, Khallafi, Hicham, additional, Kluwe, Johannes, additional, Kohli, Anita, additional, Korenblat, Kevin, additional, Kowdley, Kris, additional, Krag, Aleksander, additional, Krause, Richard, additional, Kremer, Andreas, additional, Krok, Karen, additional, Krstic, Miodrag, additional, Kugelmas, Marcelo, additional, Kumar, Sonal, additional, Kuwada, Scott, additional, Labarriere, Damien, additional, Lai, Michelle, additional, Laleman, Wim, additional, Lampertico, Pietro, additional, Lee, Alice, additional, Leroy, Vincent, additional, Lidofsky, Steven, additional, Lim, Tina Huey, additional, Lim, Joseph, additional, Lipkis, Donald, additional, Little, Ester, additional, Lonardo, Amadeo, additional, Long, Michelle, additional, Luketic, Velimir Anthony Christopher, additional, Lurie, Yoav, additional, Macedo, Guilherme, additional, Magalhaes, Joana, additional, Makara, Mihály, additional, Maliakkal, Benedict, additional, Manns, Michael, additional, Manousou, Pinelopi, additional, Mantry, Parvez, additional, Marchesini, Giulio, additional, Marinho, Carla, additional, Marotta, Paul, additional, Marschall, Hanns-Ulrich, additional, Martinez, Linda, additional, Mayo, Marlyn, additional, McCullen, Mark, additional, McLaughlin, William, additional, Merle, Uta, additional, Merriman, Raphael, additional, Modi, Apurva, additional, Molina, Esther, additional, Montano-Loza, Aldo, additional, Monteverde, Carlos, additional, Morales Cardona, Amilcar, additional, Moreea, Sulleman, additional, Moreno, Christophe, additional, Morisco, Filomena, additional, Mubarak, Abdullah, additional, Muellhaupt, Beat, additional, Mukherjee, Sandeep, additional, Müller, Tobias, additional, Nagorni, Aleksandar, additional, Naik, Jahnavi, additional, Neff, Guy, additional, Nevah, Moises, additional, Newsome, Philip, additional, Nguyen-Khac, Eric, additional, Noureddin, Mazen, additional, Oben, Jude, additional, Orlent, Hans, additional, Orr, James, additional, Ortiz-Lasanta, Grisell, additional, Ozenne, Violaine, additional, Pandya, Prashant, additional, Paredes, Angelo, additional, Park, James, additional, Patel, Joykumar, additional, Patel, Keyur, additional, Paul, Sonali, additional, Patton, Heather, additional, Peck-Radosavljevic, Markus, additional, Petta, Salvatore, additional, Pianko, Stephen, additional, Piekarska, Anna, additional, Pimstone, Neville, additional, Pisegna, Joseph, additional, Pockros, Paul, additional, Pol, Stanislas, additional, Porayko, Michael, additional, Poulos, John, additional, Pound, David, additional, Pouzar, Joe, additional, Presa Ramos, Jose, additional, Pyrsopoulos, Nikolaos, additional, Rafiq, Nila, additional, Muller, Kate, additional, Ramji, Alnoor, additional, Ravinuthala, Ravi, additional, Reddy, Chakradhar, additional, Reddy K G, Gautham, additional, Reddy K R, K. Rajender, additional, Regenstein, Frederic, additional, Reindollar, Robert, additional, Reynolds, Justin, additional, Riera, Andres, additional, Rivera Acosta, Jose, additional, Robaeys, Geert, additional, Roberts, Stuart, additional, Rodriguez-Perez, Federico, additional, Romero, Sandor, additional, Romero-Gomez, Manuel, additional, Rubin, Raymond, additional, Rumi, Mariagrazia, additional, Rushbrook, Simon, additional, Rust, Christian, additional, Ryan, Michael, additional, Safadi, Rifaat, additional, Said, Adnan, additional, Salminen, Kimmo, additional, Samuel, Didier, additional, Santoro, John, additional, Sanyal, Arun, additional, Sarkar, Souvik, additional, Schaeffer, Cynthia, additional, Schattenberg, Jörn, additional, Schiefke, Ingolf, additional, Schiff, Eugene, additional, Schmidt, Wolfgang, additional, Schneider, Jeffrey, additional, Schouten, Jeoffrey, additional, Schultz, Michael, additional, Sebastiani, Giada, additional, Semela, David, additional, Sepe, Thomas, additional, Sheikh, Aasim, additional, Sheikh, Muhammad, additional, Sherman, Kenneth, additional, Shibolet, Oren, additional, Shiffman, Mitchell, additional, Siddique, Asma, additional, Sieberhagen, Cyril, additional, Sigal, Samuel, additional, Sikorska, Katarzyna, additional, Simon, Krzysztof, additional, Sinclair, Marie, additional, Skoien, Richard, additional, Solis, Joel, additional, Sood, Siddharth, additional, Souder, Bob, additional, Spivey, James, additional, Stal, Per, additional, Stinton, Laura, additional, Strasser, Simone, additional, Svorcan, Petar, additional, Szabo, Gyongzi, additional, Talal, Andrew, additional, Tam, Edward, additional, Tetri, Brent, additional, Thuluvath, Paul, additional, Tobias, Hillel, additional, Tomasiewicz, Krzysztof, additional, Torres, Dawn, additional, Tran, Albert, additional, Trauner, Michael, additional, Trautwein, Christian, additional, Tsochatzis, Emanuel, additional, Unitt, Esther, additional, Vargas, Victor, additional, Varkonyi, Istvan, additional, Veitsman, Ella, additional, Vespasiani Gentilucci, Umberto, additional, Victor, David, additional, Vierling, John, additional, Vincent, Catherine, additional, Vincze, Aron, additional, von der Ohe, Manfred, additional, Von Roenn, Natasha, additional, Vuppalanchi, Raj, additional, Waters, Michael, additional, Watt, Kymberly, additional, Wattacheril, Julia, additional, Weltman, Martin, additional, Wieland, Amanda, additional, Wiener, Gregory, additional, Williams A, Alonzo, additional, Williams J, Jeffrey, additional, Wilson, Jason, additional, Yataco, Maria, additional, Yoshida, Eric, additional, Younes, Ziad, additional, Yuan, Liyun, additional, Zivony, Adam, additional, Zogg, Donald, additional, Zoller, Heinz, additional, Zoulim, Fabien, additional, Zuckerman, Eli, additional, and Zuin, Massimo, additional
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- 2019
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28. Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis
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De Gottardi, Andrea, Trebicka, Jonel, Klinger, Christoph, Plessier, Aurélie, Seijo, Susana, Terziroli, Benedetta, Magenta, Lorenzo, Semela, David, Buscarini, Elisabetta, Langlet, Philippe, Görtzen, Jan, Puente, Angela, Müllhaupt, Beat, Navascuès, Carmen, Nery, Filipe, Deltenre, Pierre, Turon, Fanny, Engelmann, Cornelius, Arya, Rupen, Caca, Karel, Peck‐Radosavljevic, Markus, Leebeek, Frank W. G., Valla, Dominique, Garcia‐Pagan, Juan Carlos, Grønbæk, Henning, Beer, Jürg‐Hans, Genescà, Joan, Hidalgo, Canete, Vila, Carmen, Mihailovic, Jelena, Piscaglia, Fabio, Lasser, Luc, Fernandez‐Bermejo, Miguel, Procopet, Bogdan, Schouten, Jeoffrey, Spahr, Laurent, Sanchez, José Louis, Zipprich, Alexander, Sekhar, Mallika, Hernandez‐Guerra, Manuel, Laguna, La, Nevens, Frederik, Ferreira, Carlos Noronha, Heneghan, Michael, Albillos, Agustin, Llop, Elba, Dell'Era, Alessandra, La Mura, Vincenzo, Primignani, Massimo, Senzolo, Marco, Escarda, Ana, Mallorca, Palma, Riggio, Oliviero, Murad, Sarwa Darwish, Haas, Stephan, Bureau, Christophe, Berenguer, Marina, De Gottardi, Andrea, Trebicka, Jonel, Klinger, Christoph, Plessier, Aurélie, Seijo, Susana, Terziroli, Benedetta, Magenta, Lorenzo, Semela, David, Buscarini, Elisabetta, Langlet, Philippe, Görtzen, Jan, Puente, Angela, Müllhaupt, Beat, Navascuès, Carmen, Nery, Filipe, Deltenre, Pierre, Turon, Fanny, Engelmann, Corneliu, Arya, Rupen, Caca, Karel, Peck-Radosavljevic, Marku, Leebeek, Frank W. G., Valla, Dominique, Garcia-Pagan, Juan Carlo, on behalf of the VALDIG Investigators: [.., Fabio Piscaglia, ], University of Zurich, and Hematology
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Budd-Chiari syndrome ,medicine.medical_specialty ,Deep vein ,610 Medicine & health ,03 medical and health sciences ,Anticoagulation ,0302 clinical medicine ,Journal Article ,medicine ,Portal vein thrombosi ,Cirrhosis ,Portal vein thrombosis ,Hepatology ,Rivaroxaban ,Cirrhosi ,business.industry ,medicine.disease ,Thrombosis ,3. Good health ,Surgery ,Venous thrombosis ,medicine.anatomical_structure ,10219 Clinic for Gastroenterology and Hepatology ,Splanchnic vein thrombosis ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Apixaban ,2721 Hepatology ,Liver function ,business ,medicine.drug - Abstract
BACKGROUND: Direct-acting oral anticoagulants (DOACs) are used in patients with splanchnic vein thrombosis (SVT) and cirrhosis, but evidence for safety and efficacy in this setting is limited. Our aim was to identify indications and reasons for starting or switching to DOACs and to report adverse effects, complications and short-term outcome.METHODS: Data collection including demographic information, laboratory values, treatment and complications through the Vascular Liver Disease Interest Group Consortium.RESULTS: Forty-five centres (90%) of the consortium completed the initial eCRF. We report here a series of 94 patients from 17 centres. Thirty-six patients (38%) had cirrhosis. Child-Pugh score was 6 (range 5-8), and MELD score 10.2 (range 6-19). Indications for anticoagulation were splanchnic vein thrombosis (75%), deep vein thrombosis (5%), atrial fibrillation (14%) and others (6%). DOACs used were rivaroxaban (83%), dabigatran (11%) and apixaban (6%). Patients were followed up for a median duration of 15 months (cirrhotic) and 26.5 months (non-cirrhotic). Adverse events occurred in 17% of patients and included one case of recurrent portal vein thrombosis and five cases of bleeding. Treatment with DOACs was stopped in three cases. The major reasons for choosing DOACs were no need for monitoring or inadequacy of INR to guide anticoagulation in cirrhotic patients. Renal and liver function did not change during treatment.CONCLUSIONS: A consistent number of patients with SVT and/or cirrhosis are currently treated with DOACs, which seem to be effective and safe. These data provide a basis for performing randomized clinical trials of DOACs vs. low molecular weight heparin or vitamin K antagonists.
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- 2017
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29. Reversibiliteit van de leverfibrose
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van der Meer, Adriaan, Sonneveld, Michelle, Schouten, Jeoffrey, Janssen, HLA, Gastroenterology & Hepatology, and Hematology
- Published
- 2014
30. Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study
- Author
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Koehler, Edith M., primary, Plompen, Elisabeth P.C., additional, Schouten, Jeoffrey N.L., additional, Hansen, Bettina E., additional, Darwish Murad, Sarwa, additional, Taimr, Pavel, additional, Leebeek, Frank W.G., additional, Hofman, Albert, additional, Stricker, Bruno H., additional, Castera, Laurent, additional, and Janssen, Harry L.A., additional
- Published
- 2015
- Full Text
- View/download PDF
31. Etiology and clinical outcomes of idiopathic noncirrothic portal hypertension
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Schouten, Jeoffrey, Janssen, HLA, and Gastroenterology & Hepatology
- Published
- 2013
32. Hepatotoxiciteit bij systemische medicatie in de dermatologie: is monitoring van de levertesten nuttig?
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Schouten, Jeoffrey and Gastroenterology & Hepatology
- Published
- 2012
33. Idiopathic Noncirrhotic Intrahepatic Portal Hypertension Is an Ongoing Problem in India Reply
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Schouten, Jeoffrey, Janssen, HLA, and Gastroenterology & Hepatology
- Published
- 2011
34. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
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Chambers, John C., Zhang, Weihua, Sehmi, Joban, Li, Xinzhong, Wass, Mark N., Van der Harst, Pim, Holm, Hilma, Sanna, Serena, Kavousi, Maryam, Baumeister, Sebastian E., Coin, Lachlan J., Deng, Guohong, Gieger, Christian, Heard-Costa, Nancy L., Hottenga, Jouke-Jan, Kühnel, Brigitte, Kumar, Vinod, Lagou, Vasiliki, Liang, Liming, Luan, Jian'an, Vidal, Pedro Marques, Mateo Leach, Irene, O'Reilly, Paul F., Peden, John F., Rahmioglu, Nilufer, Soininen, Pasi, Speliotes, Elizabeth K., Yuan, Xin, Thorleifsson, Gudmar, Alizadeh, Behrooz Z., Atwood, Larry D., Borecki, Ingrid B., Brown, Morris J., Charoen, Pimphen, Cucca, Francesco, Das, Debashish, de Geus, Eco J. C., Dixon, Anna L., Döring, Angela, Ehret, Georg, Eyjolfsson, Gudmundur I., Farrall, Martin, Forouhi, Nita G., Friedrich, Nele, Goessling, Wolfram, Gudbjartsson, Daniel F., Harris, Tamara B., Hartikainen, Anna-Liisa, Heath, Simon, Hirschfield, Gideon M., Hofman, Albert, Homuth, Georg, Hyppönen, Elina, Janssen, Harry L. A., Johnson, Toby, Kangas, Antti J., Kema, Ido P., Kühn, Jens P., Lai, Sandra, Lathrop, Mark, Lerch, Markus M., Li, Yun, Liang, T. Jake, Lin, Jing-Ping, Loos, Ruth J. F., Martin, Nicholas G., Moffatt, Miriam F., Montgomery, Grant W., Munroe, Patricia B., Musunuru, Kiran, Nakamura, Yusuke, O'Donnell, Christopher J., Olafsson, Isleifur, Penninx, Brenda W., Pouta, Anneli, Prins, Bram P., Prokopenko, Inga, Puls, Ralf, Ruokonen, Aimo, Savolainen, Markku J., Schlessinger, David, Schouten, Jeoffrey N. L., Seedorf, Udo, Sen-Chowdhry, Srijita, Siminovitch, Katherine A., Smit, Johannes H., Spector, Timothy D., Tan, Wenting, Teslovich, Tanya M., Tukiainen, Taru, Uitterlinden, Andre G., Van der Klauw, Melanie M., Vasan, Ramachandran S., Wallace, Chris, Wallaschofski, Henri, Wichmann, H-Erich, Willemsen, Gonneke, Würtz, Peter, Xu, Chun, Yerges-Armstrong, Laura M., Alcohol Genome-wide Association Consortium, Diabetes Genetics Replication, Meta-analyses Study, Genetic Investigation of Anthropometric Traits Consortium, Global Lipids Genetics Consortium, Genetics of Liver Disease Consortium, International Consortium for Blood Pressure, Meta-analyses of Glucose, Insulin-Related Traits Consortium, Abecasis, Goncalo R., Ahmadi, Kourosh R., Boomsma, Dorret I., Caulfield, Mark, Cookson, William O., van Duijn, Cornelia M., Froguel, Philippe, Matsuda, Koichi, McCarthy, Mark I., Meisinger, Christa, Mooser, Vincent, Pietiläinen, Kirsi H., Schumann, Gunter, Snieder, Harold, Sternberg, Michael J. E., Stolk, Ronald P., Thomas, Howard C., Thorsteinsdottir, Unnur, Uda, Manuela, Waeber, Gérard, Wareham, Nicholas J., Waterworth, Dawn M., Watkins, Hugh, Whitfield, John B., Witteman, Jacqueline C. M., Wolffenbuttel, Bruce H. R., Fox, Caroline S., Ala-Korpela, Mika, Stefansson, Kari, Vollenweider, Peter, Völzke, Henry, Schadt, Eric E., Scott, James, Järvelin, Marjo-Riitta, Elliott, Paul, and Kooner, Jaspal S.
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- 2011
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35. Idiopathic non-cirrhotic portal hypertension: a review
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Schouten, Jeoffrey NL, primary, Verheij, Joanne, additional, and Seijo, Susana, additional
- Published
- 2015
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- View/download PDF
36. Niet-cirrotische portale hypertensie
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Schouten, Jeoffrey, Verheij, Joanne, Janssen, HLA, Gastroenterology & Hepatology, and Pathology
- Published
- 2010
37. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in the general population: the Rotterdam Study
- Author
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Plompen, Elisabeth P C, primary, Hansen, Bettina E, additional, Schouten, Jeoffrey N L, additional, Darwish Murad, Sarwa, additional, Loth, Daan W, additional, Brouwer, Willem Pieter, additional, Isaacs, Aaron, additional, Taimr, Pavel, additional, Hofman, Albert, additional, van Duijn, Cornelia M, additional, Uitterlinden, André G, additional, C Stricker, Bruno H, additional, Leebeek, Frank W G, additional, and Janssen, Harry L A, additional
- Published
- 2014
- Full Text
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38. Onderzoeksmethoden in de hepatologie
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Schouten, Jeoffrey, Janssen, HLA, Drenth, JPH, van Hoek, B, and Gastroenterology & Hepatology
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- 2009
39. In process citation
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de Knegt, Rob, Schouten, Jeoffrey, Taimr, Pavel, and Gastroenterology & Hepatology
- Published
- 2008
40. Multiple biopsy passes and the risk of complications of percutaneous liver biopsy.
- Author
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Heng Chi, Hansen, Bettina E., Wing Yin Tang, Schouten, Jeoffrey N. L., Sprengers, Dave, Taimr, Pavel, Janssen, Harry L. A., and de Knegt, Robert J.
- Published
- 2017
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41. Serum liver enzymes are associated with all‐cause mortality in an elderly population
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Koehler, Edith M., primary, Sanna, Donatella, additional, Hansen, Bettina E., additional, van Rooij, Frank J., additional, Heeringa, Jan, additional, Hofman, Albert, additional, Tiemeier, Henning, additional, Stricker, Bruno H., additional, Schouten, Jeoffrey N. L., additional, and Janssen, Harry L. A., additional
- Published
- 2013
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42. Increased Prevalence of Advanced Liver Fibrosis in Patients with Psoriasis: A Cross-sectional Analysis from the Rotterdam Study.
- Author
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VAN DER VOORT, Ella A. M., KOEHLER, Edith M., NIJSTEN, Tamar, STRICKER, Bruno H., HOFMAN, Albert, JANSSEN, Harry L. A., SCHOUTEN, Jeoffrey N. L., and WAKKEE, Marlies
- Subjects
DISEASE prevalence ,FIBROSIS ,LIVER diseases ,CROSS-sectional method ,ELASTOGRAPHY ,PSORIASIS - Abstract
Prevalence of non-alcoholic fatty liver disease is increased in patients with psoriasis. However, it is not known how liver fibrosis correlates with psoriasis. This study investigated the association between psoriasis and liver fibrosis compared with participants without psoriasis within the population-based Rotterdam Study. All participants were screened for liver fibrosis using transient elastography. Liver stiffness > 9.5 kPa suggested advanced liver fibrosis. Psoriasis was identified using a validated algorithm. A total of 1,535 participants were included (mean age ± standard deviation 70.5 ± 7.9 years; 50.8% female; median body mass index 26.4 kg/ m
2 (interquartile range 24.2-28.9)) of whom 74 (4.7%) had psoriasis. Prevalence of advanced liver fibrosis was 8.1% in psoriasis patients compared with 3.6% in the reference group (p = 0.05). The risk of advanced liver fibrosis in psoriasis patients remained comparable after adjustment for demographics, lifestyle characteristics and laboratory findings (odds ratio 2.57 (95% confidence interval 1.00-6.63). This study suggests that elderly people with psoriasis are twice as likely to have advanced liver fibrosis irrespective of common risk factors. [ABSTRACT FROM AUTHOR]- Published
- 2016
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43. Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: Results from the Rotterdam study
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Koehler, Edith M., primary, Schouten, Jeoffrey N.L., additional, Hansen, Bettina E., additional, van Rooij, Frank J.A., additional, Hofman, Albert, additional, Stricker, Bruno H., additional, and Janssen, Harry L.A., additional
- Published
- 2012
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44. A Direct Comparison of CT-Angiography With Ultrasonography for the Detection of Mesenteric Artery Stenoses
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Moons, Leon M., primary, Moelker, Adriaan, additional, Leertouwer, Trude C., additional, Sana, Aria, additional, Kuipers, Ernst J., additional, and Schouten, Jeoffrey N., additional
- Published
- 2011
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45. Faculty Opinions recommendation of Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis.
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Janssen, Harry, primary and Schouten, Jeoffrey, additional
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- 2010
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46. Comparison between Endogenous Thrombin Potential (ETP) and INR To Assess Liver Function in Patients with Liver Cirrhosis.
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Schouten, Jeoffrey, primary, Gadisseur, Alain P., primary, Franque, Sven, primary, Van der Planken, Marc, primary, Michielsen, Peter, primary, and Berneman, Zwi N., primary
- Published
- 2006
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47. Routine Measurement of Endogenous Thrombin Potential (ETP) To Assess Hemostatic Function in Patients with Liver Cirrhosis.
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Gadisseur, Alain P., primary, Schouten, Jeoffrey, primary, Franque, Sven, primary, Van der Planken, Marc, primary, Michielsen, Peter, primary, and Berneman, Zwi N., primary
- Published
- 2006
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48. A new 'treatment-response score' for AUTO immune hepatitis is predictive of LONG-TERM event-free survival and overall survival : a multicenter Belgian cohort study
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Simoen, Cedric, Schouten, Jeoffrey, Isabelle Colle, Steenkiste, Christophe, Sermon, Filip, Anne Hoorens, anja geerts, Hans Van Vlierberghe, and Xavier Verhelst
49. FRI163 - Development and validation of a novel risk score predicting long-term survival in autoimmune hepatitis.
- Author
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Biewenga, Maaike, Xavier, Verhelst, Baven-Pronk, Martine, Putter, Hein, van den Berg, Aad, van Nieuwkerk, Karin, Van Buuren, Henk, Bouma, Gerd, de Boer, Ynte, Simoen, Cedric, Colle, Isabelle, Schouten, Jeoffrey, Sermon, Filip, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Van der Meer, Adriaan, Nevens, Frederik, and Van Hoek, Bart
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- *
CHRONIC active hepatitis - Published
- 2020
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50. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
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Zobair M Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N Newsome, David Sheridan, Muhammad Y Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F Abdelmalek, Kris V Kowdley, Aldo J Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean-Francois Dufour, David Shapiro, Jason Campagna, Luna Zaru, Leigh MacConell, Reshma Shringarpure, Stephen Harrison, Arun J Sanyal, Manal Abdelmalek, Gary Abrams, Humberto Aguilar, Aijaz Ahmed, Elmar Aigner, Guruprasad Aithal, Aftab Ala, William Alazawi, Agustin Albillos, Michael Allison, Sfa Al-Shamma, Raul Andrade, Pietro Andreone, Mario Angelico, Victor Ankoma-Sey, Quentin Anstee, Rodolphe Anty, Victor Araya, Juan Ignacio Arenas Ruiz, Perttu Arkkila, Marty Arora, Tarik Asselah, Jennifer Au, Oyekoya Ayonrinde, Robert James Bailey, Maya Balakrishnan, Kiran Bambha, Meena Bansal, Sidney Barritt, John Bate, Jorge Beato, Jaideep Behari, Pablo Bellot, Ziv Ben Ari, Michael Bennett, Marina Berenguer, Benedetta Terziroli Beretta-Piccoli, Thomas Berg, Maurizio Bonacini, Lucia Bonet, Brian Borg, Marc Bourliere, William Bowman, David Bradley, Marija Brankovic, Marius Braun, Jean-Pierre Bronowicki, Savino Bruno, Cindy Cai, Amy Calderon, José Luis Calleja Panero, Elizabeth Carey, Michal Carmiel, Jose Antonio Carrión, Matthew Cave, Cristina Chagas, Tawfik Chami, Alan Chang, Allan Coates, Jeremy Cobbold, Charlote Costentin, Kathleen Corey, Lynsey Corless, Javier Crespo, Oscar Cruz Pereira, Victor de Ledinghen, Andrew deLemos, Moises Diago, Mamie Dong, Jean-François Dufour, Predrag Dugalic, Winston Dunn, Magby Elkhashab, Michael Epstein, Maria Desamparados Escudero-Garcia, Ohad Etzion, Larry Evans, Robert Falcone, Conrado Fernandez, Jose Ferreira, Scott Fink, Kevin Finnegan, Roberto Firpi-Morell, Annarosa Floreani, Thierry Fontanges, Ryan Ford, Ewan Forrest, Andrew Fowell, Anna Ludovica Fracanzani, Sven Francque, Bradley Freilich, Juan Frias, Michael Fuchs, Javier Fuentes, Michael Galambos, Juan Gallegos, Anja Geerts, Jacob George, Maged Ghali, Reem Ghalib, Pierre Gholam, Pere Gines, Norman Gitlin, Tobias Goeser, John Goff, Stuart Gordon, Frederic Gordon, Odile Goria, Shaun Greer, Alla Grigorian, Henning Gronbaek, Maeva Guillaume, Naresh Gunaratnam, Dina Halegoua-De Marzio, Bilal Hameed, Stephanie Hametner, James Hamilton, Marek Hartleb, Tarek Hassanein, Dieter Häussinger, Paul Hellstern, Robert Herring, Eva Heurich, Christophe Hezode, Holger Hinrichsen, Peter Holland Fischer, Yves Horsmans, Jonathan Huang, Hyder Hussaini, Antoine Jakiche, Lennox Jeffers, Blake Jones, Rosa Jorge, Francisco Jorquera, Shoba Joshi, Alisan Kahraman, Kelly Kaita, Nicholas Karyotakis, Zeid Kayali, Stergios Kechagias, Thomas Kepczyk, Mandana Khalili, Hicham Khallafi, Johannes Kluwe, Anita Kohli, Kevin Korenblat, Kris Kowdley, Aleksander Krag, Richard Krause, Andreas Kremer, Karen Krok, Miodrag Krstic, Marcelo Kugelmas, Sonal Kumar, Scott Kuwada, Damien Labarriere, Michelle Lai, Wim Laleman, Pietro Lampertico, Alice Lee, Vincent Leroy, Steven Lidofsky, Tina Huey Lim, Joseph Lim, Donald Lipkis, Ester Little, Amadeo Lonardo, Michelle Long, Velimir Anthony Christopher Luketic, Yoav Lurie, Guilherme Macedo, Joana Magalhaes, Mihály Makara, Benedict Maliakkal, Michael Manns, Pinelopi Manousou, Parvez Mantry, Giulio Marchesini, Carla Marinho, Paul Marotta, Hanns-Ulrich Marschall, Linda Martinez, Marlyn Mayo, Mark McCullen, William McLaughlin, Uta Merle, Raphael Merriman, Apurva Modi, Esther Molina, Aldo Montano-Loza, Carlos Monteverde, Amilcar Morales Cardona, Sulleman Moreea, Christophe Moreno, Filomena Morisco, Abdullah Mubarak, Beat Muellhaupt, Sandeep Mukherjee, Tobias Müller, Aleksandar Nagorni, Jahnavi Naik, Guy Neff, Moises Nevah, Philip Newsome, Eric Nguyen-Khac, Mazen Noureddin, Jude Oben, Hans Orlent, James Orr, Grisell Ortiz-Lasanta, Violaine Ozenne, Prashant Pandya, Angelo Paredes, James Park, Joykumar Patel, Keyur Patel, Sonali Paul, Heather Patton, Markus Peck-Radosavljevic, Salvatore Petta, Stephen Pianko, Anna Piekarska, Neville Pimstone, Joseph Pisegna, Paul Pockros, Stanislas Pol, Michael Porayko, John Poulos, David Pound, Joe Pouzar, Jose Presa Ramos, Nikolaos Pyrsopoulos, Nila Rafiq, Kate Muller, Alnoor Ramji, Ravi Ravinuthala, Chakradhar Reddy, Gautham Reddy K G, K. Rajender Reddy K R, Frederic Regenstein, Robert Reindollar, Justin Reynolds, Andres Riera, Jose Rivera Acosta, Geert Robaeys, Stuart Roberts, Federico Rodriguez-Perez, Sandor Romero, Manuel Romero-Gomez, Raymond Rubin, Mariagrazia Rumi, Simon Rushbrook, Christian Rust, Michael Ryan, Rifaat Safadi, Adnan Said, Kimmo Salminen, Didier Samuel, John Santoro, Arun Sanyal, Souvik Sarkar, Cynthia Schaeffer, Jörn Schattenberg, Ingolf Schiefke, Eugene Schiff, Wolfgang Schmidt, Jeffrey Schneider, Jeoffrey Schouten, Michael Schultz, Giada Sebastiani, David Semela, Thomas Sepe, Aasim Sheikh, Muhammad Sheikh, Kenneth Sherman, Oren Shibolet, Mitchell Shiffman, Asma Siddique, Cyril Sieberhagen, Samuel Sigal, Katarzyna Sikorska, Krzysztof Simon, Marie Sinclair, Richard Skoien, Joel Solis, Siddharth Sood, Bob Souder, James Spivey, Per Stal, Laura Stinton, Simone Strasser, Petar Svorcan, Gyongzi Szabo, Andrew Talal, Edward Tam, Brent Tetri, Paul Thuluvath, Hillel Tobias, Krzysztof Tomasiewicz, Dawn Torres, Albert Tran, Michael Trauner, Christian Trautwein, Emanuel Tsochatzis, Esther Unitt, Victor Vargas, Istvan Varkonyi, Ella Veitsman, Umberto Vespasiani Gentilucci, David Victor, John Vierling, Catherine Vincent, Aron Vincze, Manfred von der Ohe, Natasha Von Roenn, Raj Vuppalanchi, Michael Waters, Kymberly Watt, Julia Wattacheril, Martin Weltman, Amanda Wieland, Gregory Wiener, Alonzo Williams A, Jeffrey Williams J, Jason Wilson, Maria Yataco, Eric Yoshida, Ziad Younes, Liyun Yuan, Adam Zivony, Donald Zogg, Heinz Zoller, Fabien Zoulim, Eli Zuckerman, Massimo Zuin, Younossi Z.M., Ratziu V., Loomba R., Rinella M., Anstee Q.M., Goodman Z., Bedossa P., Geier A., Beckebaum S., Newsome P.N., Sheridan D., Sheikh M.Y., Trotter J., Knapple W., Lawitz E., Abdelmalek M.F., Kowdley K.V., Montano-Loza A.J., Boursier J., Mathurin P., Bugianesi E., Mazzella G., Olveira A., Cortez-Pinto H., Graupera I., Orr D., Gluud L.L., Dufour J.-F., Shapiro D., Campagna J., Zaru L., MacConell L., Shringarpure R., Harrison S., Sanyal A.J., Abdelmalek M., Abrams G., Aguilar H., Ahmed A., Aigner E., Aithal G., Ala A., Alazawi W., Albillos A., Allison M., Al-Shamma S., Andrade R., Andreone P., Angelico M., Ankoma-Sey V., Anstee Q., Anty R., Araya V., Arenas Ruiz J.I., Arkkila P., Arora M., Asselah T., Au J., Ayonrinde O., Bailey R.J., Balakrishnan M., Bambha K., Bansal M., Barritt S., Bate J., Beato J., Behari J., Bellot P., Ben Ari Z., Bennett M., Berenguer M., Beretta-Piccoli B.T., Berg T., Bonacini M., Bonet L., Borg B., Bourliere M., Bowman W., Bradley D., Brankovic M., Braun M., Bronowicki J.-P., Bruno S., Cai C., Calleja Panero J.L., Carey E., Carmiel M., Carrion J.A., Cave M., Chagas C., Chami T., Chang A., Coates A., Cobbold J., Corey K., Corless L., Crespo J., Cruz Pereira O., de Ledinghen V., deLemos A., Diago M., Dugalic P., Dunn W., Elkhashab M., Epstein M., Escudero-Garcia M.D., Etzion O., Evans L., Falcone R., Fernandez C., Ferreira J., Fink S., Finnegan K., Firpi-Morell R., Floreani A., Fontanges T., Ford R., Forrest E., Fowell A., Fracanzani A.L., Francque S., Freilich B., Frias J., Fuchs M., Fuentes J., Galambos M., Gallegos J., Geerts A., George J., Ghali M., Ghalib R., Gholam P., Gines P., Gitlin N., Goeser T., Goff J., Gordon S., Gordon F., Goria O., Greer S., Grigorian A., Gronbaek H., Guillaume M., Gunaratnam N., Halegoua-De Marzio D., Hameed B., Hametner S., Hamilton J., Hartleb M., Hassanein T., Haussinger D., Hellstern P., Herring R., Heurich E., Hezode C., Hinrichsen H., Holland Fischer P., Horsmans Y., Huang J., Jakiche A., Jeffers L., Jones B., Jorge R., Jorquera F., Kahraman A., Kaita K., Karyotakis N., Kayali Z., Kechagias S., Kepczyk T., Khalili M., Khallafi H., Kluwe J., Kohli A., Korenblat K., Kowdley K., Krag A., Krause R., Kremer A., Krok K., Krstic M., Kugelmas M., Kumar S., Labarriere D., Lai M., Lampertico P., Lee A., Leroy V., Lidofsky S., Lim T.H., Lim J., Lipkis D., Little E., Lonardo A., Long M., Lurie Y., Macedo G., Makara M., Maliakkal B., Manns M., Manousou P., Mantry P., Marchesini G., Marinho C., Marotta P., Marschall H.-U., Mayo M., McCullen M., McLaughlin W., Merriman R., Modi A., Molina E., Montano-Loza A., Monteverde C., Moreea S., Moreno C., Morisco F., Mubarak A., Muellhaupt B., Mukherjee S., Muller T., Nagorni A., Naik J., Neff G., Nevah M., Newsome P., Nguyen-Khac E., Noureddin M., Oben J., Orlent H., Orr J., Ortiz-Lasanta G., Ozenne V., Pandya P., Paredes A., Park J., Patel J., Patel K., Uta M., Patton H., Peck-Radosavljevic M., Petta S., Pianko S., Piekarska A., Pimstone N., Pockros P., Pol S., Porayko M., Poulos J., Pound D., Pouzar J., Presa Ramos J., Pyrsopoulos N., Rafiq N., Muller K., Ramji A., Ravinuthala R., Reddy C., Reddy K G G., Reddy K R K.R., Regenstein F., Reindollar R., Riera A., Rivera Acosta J., Robaeys G., Roberts S., Rodriguez-Perez F., Romero-Gomez M., Rubin R., Rumi M., Rushbrook S., Rust C., Ryan M., Safadi R., Said A., Salminen K., Samuel D., Santoro 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L., Francque, S., Freilich, B., Frias, J., Fuchs, M., Fuentes, J., Galambos, M., Gallegos, J., Geerts, A., George, J., Ghali, M., Ghalib, R., Gholam, P., Gines, P., Gitlin, N., Goeser, T., Goff, J., Gordon, S., Gordon, F., Goria, O., Greer, S., Grigorian, A., Gronbaek, H., Guillaume, M., Gunaratnam, N., Halegoua-De Marzio, D., Hameed, B., Hametner, S., Hamilton, J., Hartleb, M., Hassanein, T., Haussinger, D., Hellstern, P., Herring, R., Heurich, E., Hezode, C., Hinrichsen, H., Holland Fischer, P., Horsmans, Y., Huang, J., Jakiche, A., Jeffers, L., Jones, B., Jorge, R., Jorquera, F., Kahraman, A., Kaita, K., Karyotakis, N., Kayali, Z., Kechagias, S., Kepczyk, T., Khalili, M., Khallafi, H., Kluwe, J., Kohli, A., Korenblat, K., Kowdley, K., Krag, A., Krause, R., Kremer, A., Krok, K., Krstic, M., Kugelmas, M., Kumar, S., Labarriere, D., Lai, M., Lampertico, P., Lee, A., Leroy, V., Lidofsky, S., Lim, T. H., Lim, J., Lipkis, D., Little, E., Lonardo, A., Long, M., Lurie, Y., Macedo, G., Makara, M., Maliakkal, B., Manns, M., Manousou, P., Mantry, P., Marchesini, G., Marinho, C., Marotta, P., Marschall, H. -U., Mayo, M., Mccullen, M., Mclaughlin, W., Merriman, R., Modi, A., Molina, E., Montano-Loza, A., Monteverde, C., Moreea, S., Moreno, C., Morisco, F., Mubarak, A., Muellhaupt, B., Mukherjee, S., Muller, T., Nagorni, A., Naik, J., Neff, G., Nevah, M., Newsome, P., Nguyen-Khac, E., Noureddin, M., Oben, J., Orlent, H., Orr, J., Ortiz-Lasanta, G., Ozenne, V., Pandya, P., Paredes, A., Park, J., Patel, J., Patel, K., Uta, M., Patton, H., Peck-Radosavljevic, M., Petta, S., Pianko, S., Piekarska, A., Pimstone, N., Pockros, P., Pol, S., Porayko, M., Poulos, J., Pound, D., Pouzar, J., Presa Ramos, J., Pyrsopoulos, N., Rafiq, N., Muller, K., Ramji, A., Ravinuthala, R., Reddy, C., Reddy K G, G., Reddy K R, K. R., Regenstein, F., Reindollar, R., Riera, A., Rivera Acosta, J., Robaeys, G., Roberts, S., Rodriguez-Perez, F., Romero-Gomez, M., Rubin, R., Rumi, M., Rushbrook, S., Rust, C., Ryan, M., Safadi, R., Said, A., Salminen, K., Samuel, D., Santoro, J., Sanyal, A., Sarkar, S., Schaeffer, C., Schattenberg, J., Schiefke, I., Schiff, E., Schmidt, W., Schneider, J., Schouten, J., Schultz, M., Sebastiani, G., Semela, D., Sepe, T., Sheikh, A., Sheikh, M., Sherman, K., Shibolet, O., Shiffman, M., Siddique, A., Sieberhagen, C., Sigal, S., Sikorska, K., Simon, K., Sinclair, M., Skoien, R., Solis, J., Sood, S., Souder, B., Spivey, J., Stal, P., Stinton, L., Strasser, S., Svorcan, P., Szabo, G., Talal, A., Tam, E., Tetri, B., Thuluvath, P., Tobias, H., Tomasiewicz, K., Torres, D., Trauner, M., Trautwein, C., Tsochatzis, E., Unitt, E., Vargas, V., Varkonyi, I., Veitsman, E., Vespasiani Gentilucci, U., Victor, D., Vierling, J., Vincent, C., Vincze, A., von der Ohe, M., Von Roenn, N., Vuppalanchi, R., Waters, M., Watt, K., Weltman, M., Wieland, A., Wiener, G., Williams A, A., Williams J, J., Wilson, J., Yataco, M., Yoshida, E., Younes, Z., Yuan, L., Zivony, A., Zogg, D., Zoller, H., Zoulim, F., Zuckerman, E., Zuin, M., Younossi, Zobair M, Ratziu, Vlad, Loomba, Rohit, Rinella, Mary, Anstee, Quentin M, Goodman, Zachary, Bedossa, Pierre, Geier, Andrea, Beckebaum, Susanne, Newsome, Philip N, Sheridan, David, Sheikh, Muhammad Y, Trotter, Jame, Knapple, Whitfield, Lawitz, Eric, Abdelmalek, Manal F, Kowdley, Kris V, Montano-Loza, Aldo J, Boursier, Jerome, Mathurin, Philippe, Bugianesi, Elisabetta, Mazzella, Giuseppe, Olveira, Antonio, Cortez-Pinto, Helena, Graupera, Isabel, Orr, David, Gluud, Lise Lotte, Dufour, Jean-Francoi, Shapiro, David, Campagna, Jason, Zaru, Luna, MacConell, Leigh, Shringarpure, Reshma, Harrison, Stephen, Sanyal, Arun J, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Ahmed, Aijaz, Aigner, Elmar, Aithal, Guruprasad, Ala, Aftab, Alazawi, William, Albillos, Agustin, Allison, Michael, Al-Shamma, Sfa, Andrade, Raul, Andreone, Pietro, Angelico, Mario, Ankoma-Sey, Victor, Anstee, Quentin, Anty, Rodolphe, Araya, Victor, Arenas Ruiz, Juan Ignacio, Arkkila, Perttu, Arora, Marty, Asselah, Tarik, Au, Jennifer, Ayonrinde, Oyekoya, Bailey, Robert Jame, Balakrishnan, Maya, Bambha, Kiran, Bansal, Meena, Barritt, Sidney, Bate, John, Beato, Jorge, Behari, Jaideep, Bellot, Pablo, Ben Ari, Ziv, Bennett, Michael, Berenguer, Marina, Beretta-Piccoli, Benedetta Terziroli, Berg, Thoma, Bonacini, Maurizio, Bonet, Lucia, Borg, Brian, Bourliere, Marc, Bowman, William, Bradley, David, Brankovic, Marija, Braun, Mariu, Bronowicki, Jean-Pierre, Bruno, Savino, Cai, Cindy, Calleja Panero, José Lui, Carey, Elizabeth, Carmiel, Michal, Carrión, Jose Antonio, Cave, Matthew, Chagas, Cristina, Chami, Tawfik, Chang, Alan, Coates, Allan, Cobbold, Jeremy, Corey, Kathleen, Corless, Lynsey, Crespo, Javier, Cruz Pereira, Oscar, de Ledinghen, Victor, deLemos, Andrew, Diago, Moise, Dufour, Jean-Françoi, Dugalic, Predrag, Dunn, Winston, Elkhashab, Magby, Epstein, Michael, Escudero-Garcia, Maria Desamparado, Etzion, Ohad, Evans, Larry, Falcone, Robert, Fernandez, Conrado, Ferreira, Jose, Fink, Scott, Finnegan, Kevin, Firpi-Morell, Roberto, Floreani, Annarosa, Fontanges, Thierry, Ford, Ryan, Forrest, Ewan, Fowell, Andrew, Fracanzani, Anna Ludovica, Francque, Sven, Freilich, Bradley, Frias, Juan, Fuchs, Michael, Fuentes, Javier, Galambos, Michael, Gallegos, Juan, Geerts, Anja, George, Jacob, Ghali, Maged, Ghalib, Reem, Gholam, Pierre, Gines, Pere, Gitlin, Norman, Goeser, Tobia, Goff, John, Gordon, Stuart, Gordon, Frederic, Goria, Odile, Greer, Shaun, Grigorian, Alla, Gronbaek, Henning, Guillaume, Maeva, Gunaratnam, Naresh, Halegoua-De Marzio, Dina, Hameed, Bilal, Hametner, Stephanie, Hamilton, Jame, Hartleb, Marek, Hassanein, Tarek, Häussinger, Dieter, Hellstern, Paul, Herring, Robert, Heurich, Eva, Hezode, Christophe, Hinrichsen, Holger, Holland Fischer, Peter, Horsmans, Yve, Huang, Jonathan, Jakiche, Antoine, Jeffers, Lennox, Jones, Blake, Jorge, Rosa, Jorquera, Francisco, Kahraman, Alisan, Kaita, Kelly, Karyotakis, Nichola, Kayali, Zeid, Kechagias, Stergio, Kepczyk, Thoma, Khalili, Mandana, Khallafi, Hicham, Kluwe, Johanne, Kohli, Anita, Korenblat, Kevin, Kowdley, Kri, Krag, Aleksander, Krause, Richard, Kremer, Andrea, Krok, Karen, Krstic, Miodrag, Kugelmas, Marcelo, Kumar, Sonal, Labarriere, Damien, Lai, Michelle, Lampertico, Pietro, Lee, Alice, Leroy, Vincent, Lidofsky, Steven, Lim, Tina Huey, Lim, Joseph, Lipkis, Donald, Little, Ester, Lonardo, Amadeo, Long, Michelle, Lurie, Yoav, Macedo, Guilherme, Makara, Mihály, Maliakkal, Benedict, Manns, Michael, Manousou, Pinelopi, Mantry, Parvez, Marchesini, Giulio, Marinho, Carla, Marotta, Paul, Marschall, Hanns-Ulrich, Mayo, Marlyn, McCullen, Mark, McLaughlin, William, Merriman, Raphael, Modi, Apurva, Molina, Esther, Montano-Loza, Aldo, Monteverde, Carlo, Moreea, Sulleman, Moreno, Christophe, Morisco, Filomena, Mubarak, Abdullah, Muellhaupt, Beat, Mukherjee, Sandeep, Müller, Tobia, Nagorni, Aleksandar, Naik, Jahnavi, Neff, Guy, Nevah, Moise, Newsome, Philip, Nguyen-Khac, Eric, Noureddin, Mazen, Oben, Jude, Orlent, Han, Orr, Jame, Ortiz-Lasanta, Grisell, Ozenne, Violaine, Pandya, Prashant, Paredes, Angelo, Park, Jame, Patel, Joykumar, Patel, Keyur, Uta, Merle, Patton, Heather, Peck-Radosavljevic, Marku, Petta, Salvatore, Pianko, Stephen, Piekarska, Anna, Pimstone, Neville, Pockros, Paul, Pol, Stanisla, Porayko, Michael, Poulos, John, Pound, David, Pouzar, Joe, Presa Ramos, Jose, Pyrsopoulos, Nikolao, Rafiq, Nila, Muller, Kate, Ramji, Alnoor, Ravinuthala, Ravi, Reddy, Chakradhar, Reddy K G, Gautham, Reddy K R, K. Rajender, Regenstein, Frederic, Reindollar, Robert, Riera, Andre, Rivera Acosta, Jose, Robaeys, Geert, Roberts, Stuart, Rodriguez-Perez, Federico, Romero-Gomez, Manuel, Rubin, Raymond, Rumi, Mariagrazia, Rushbrook, Simon, Rust, Christian, Ryan, Michael, Safadi, Rifaat, Said, Adnan, Salminen, Kimmo, Samuel, Didier, Santoro, John, Sanyal, Arun, Sarkar, Souvik, Schaeffer, Cynthia, Schattenberg, Jörn, Schiefke, Ingolf, Schiff, Eugene, Schmidt, Wolfgang, Schneider, Jeffrey, Schouten, Jeoffrey, Schultz, Michael, Sebastiani, Giada, Semela, David, Sepe, Thoma, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shibolet, Oren, Shiffman, Mitchell, Siddique, Asma, Sieberhagen, Cyril, Sigal, Samuel, Sikorska, Katarzyna, Simon, Krzysztof, Sinclair, Marie, Skoien, Richard, Solis, Joel, Sood, Siddharth, Souder, Bob, Spivey, Jame, Stal, Per, Stinton, Laura, Strasser, Simone, Svorcan, Petar, Szabo, Gyongzi, Talal, Andrew, Tam, Edward, Tetri, Brent, Thuluvath, Paul, Tobias, Hillel, Tomasiewicz, Krzysztof, Torres, Dawn, Trauner, Michael, Trautwein, Christian, Tsochatzis, Emanuel, Unitt, Esther, Vargas, Victor, Varkonyi, Istvan, Veitsman, Ella, Vespasiani Gentilucci, Umberto, Victor, David, Vierling, John, Vincent, Catherine, Vincze, Aron, von der Ohe, Manfred, Von Roenn, Natasha, Vuppalanchi, Raj, Waters, Michael, Watt, Kymberly, Weltman, Martin, Wieland, Amanda, Wiener, Gregory, Williams A, Alonzo, Williams J, Jeffrey, Wilson, Jason, Yataco, Maria, Yoshida, Eric, Younes, Ziad, Yuan, Liyun, Zivony, Adam, Zogg, Donald, Zoller, Heinz, Zoulim, Fabien, Zuckerman, Eli, Zuin, Massimo, and REGENERATE Study Investigators
- Subjects
Male ,Biopsy ,Clinical Trial, Phase III ,Administration, Oral ,030204 cardiovascular system & hematology ,Chronic liver disease ,Settore MED/04 ,Biomarkers/analysis ,Gastroenterology ,chemistry.chemical_compound ,0302 clinical medicine ,Liver Function Tests ,Non-alcoholic Fatty Liver Disease ,Clinical endpoint ,Medicine ,030212 general & internal medicine ,610 Medicine & health ,Chenodeoxycholic Acid/administration & dosage ,education.field_of_study ,Liver Function Test ,Research Support, Non-U.S. Gov't ,Fatty liver ,Obeticholic acid ,NASH, OBETICHOLIC ACID ,General Medicine ,Middle Aged ,Multicenter Study ,Randomized Controlled Trial ,Administration ,Female ,Biomarkers ,Chenodeoxycholic Acid ,Double-Blind Method ,Humans ,Human ,Oral ,medicine.medical_specialty ,Population ,Placebo ,03 medical and health sciences ,Research Support, N.I.H., Extramural ,Internal medicine ,Journal Article ,education ,Intention-to-treat analysis ,business.industry ,Biomarker ,Interim analysis ,medicine.disease ,Non-alcoholic Fatty Liver Disease/drug therapy ,chemistry ,Human medicine ,business - Abstract
© 2019 Elsevier Ltd. All rights reserved., Background: Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH. Methods: In this multicentre, randomised, double-blind, placebo-controlled study, adult patients with definite NASH, non-alcoholic fatty liver disease (NAFLD) activity score of at least 4, and fibrosis stages F2-F3, or F1 with at least one accompanying comorbidity, were randomly assigned using an interactive web response system in a 1:1:1 ratio to receive oral placebo, obeticholic acid 10 mg, or obeticholic acid 25 mg daily. Patients were excluded if cirrhosis, other chronic liver disease, elevated alcohol consumption, or confounding conditions were present. The primary endpoints for the month-18 interim analysis were fibrosis improvement (≥1 stage) with no worsening of NASH, or NASH resolution with no worsening of fibrosis, with the study considered successful if either primary endpoint was met. Primary analyses were done by intention to treat, in patients with fibrosis stage F2-F3 who received at least one dose of treatment and reached, or would have reached, the month 18 visit by the prespecified interim analysis cutoff date. The study also evaluated other histological and biochemical markers of NASH and fibrosis, and safety. This study is ongoing, and registered with ClinicalTrials.gov, NCT02548351, and EudraCT, 20150-025601-6. Findings: Between Dec 9, 2015, and Oct 26, 2018, 1968 patients with stage F1-F3 fibrosis were enrolled and received at least one dose of study treatment; 931 patients with stage F2-F3 fibrosis were included in the primary analysis (311 in the placebo group, 312 in the obeticholic acid 10 mg group, and 308 in the obeticholic acid 25 mg group). The fibrosis improvement endpoint was achieved by 37 (12%) patients in the placebo group, 55 (18%) in the obeticholic acid 10 mg group (p=0·045), and 71 (23%) in the obeticholic acid 25 mg group (p=0·0002). The NASH resolution endpoint was not met (25 [8%] patients in the placebo group, 35 [11%] in the obeticholic acid 10 mg group [p=0·18], and 36 [12%] in the obeticholic acid 25 mg group [p=0·13]). In the safety population (1968 patients with fibrosis stages F1-F3), the most common adverse event was pruritus (123 [19%] in the placebo group, 183 [28%] in the obeticholic acid 10 mg group, and 336 [51%] in the obeticholic acid 25 mg group); incidence was generally mild to moderate in severity. The overall safety profile was similar to that in previous studies, and incidence of serious adverse events was similar across treatment groups (75 [11%] patients in the placebo group, 72 [11%] in the obeticholic acid 10 mg group, and 93 [14%] in the obeticholic acid 25 mg group). Interpretation: Obeticholic acid 25 mg significantly improved fibrosis and key components of NASH disease activity among patients with NASH. The results from this planned interim analysis show clinically significant histological improvement that is reasonably likely to predict clinical benefit. This study is ongoing to assess clinical outcomes.
- Published
- 2019
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