449 results on '"Schopohl, J"'
Search Results
2. Hypophysenhinterlappen
- Author
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Schopohl, J., primary and Honegger, J., additional
- Published
- 2019
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3. Autoren
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Andrié, R.P., primary, Angenendt, J., additional, Aubin, H., additional, Baldus, S., additional, Balzer, J., additional, Baltzer, J., additional, Behr, J., additional, Benz, Marcus, additional, Berger, M., additional, Blank, N., additional, Blind, E., additional, Buchfelder, M., additional, Burk, A., additional, Detter, C., additional, Diel, R., additional, Diener, H.-C., additional, Domschke, W., additional, Doppler, K., additional, Ellinger, J., additional, Epple, H.-J., additional, Erbel, R., additional, Fichtner-Feigl, S., additional, Fischereder, M., additional, Forsting, M., additional, Friedrich, M., additional, Frommberger, U., additional, Frye, B.C., additional, Goebel, F.-D., additional, Grabitz, K., additional, Groeneveld, A., additional, Gundling, F., additional, Gutt, C.N., additional, Haidl, G., additional, Hartmann, U., additional, Hausteiner-Wiehle, C., additional, Herpertz-Dahlmann, B., additional, Heuß, D., additional, Heußner, P., additional, Hiller, E., additional, Hohenfellner, U., additional, Honegger, J., additional, Hornung, T., additional, Jansen, F., additional, Jelinek, T., additional, Jordan, B., additional, Keck, C., additional, Kelm, M., additional, Kilian, A., additional, Kleindienst, A., additional, Kölbl, H., additional, Kreis, M.E., additional, Kroener-Herwig, B., additional, Külz, A.K., additional, Lammert, F., additional, Lichtenberg, A., additional, Limmroth, V., additional, Lindner, K., additional, Loddenkemper, R., additional, Lorenz, H.-M., additional, Lügering, N., additional, Mallmann, P., additional, Max, R., additional, Merle, U., additional, Mellert, F., additional, Michels, G., additional, Müller, R.-U., additional, Müller, S.C., additional, Müller-Lissner, S., additional, Müller-Quernheim, J., additional, Neuhof, C., additional, Parhofer, K.G., additional, Petri, E., additional, Pfeiffer, T., additional, Pilatz, Adrian, additional, Pizarro, C., additional, Probst, C., additional, Rascher, W., additional, Raue, F., additional, Reindl, C., additional, Riedner, C., additional, Riemann, D., additional, Röckelein, V., additional, Sandmann, W., additional, Sauerbruch, T., additional, Schahab, N., additional, Schaper, A., additional, Schepp, W., additional, Schliep, S., additional, Schnürch, H.-G., additional, Schölmerich, J., additional, Schönermarck, Ulf, additional, Schopohl, J., additional, Schuchert, A., additional, Schulze-Koops, H., additional, Schupp, J., additional, Segerer, S.E., additional, Senninger, N., additional, Seybold, U., additional, Siegmund, B., additional, Skowasch, D., additional, Sommer, C., additional, Stahl, M., additional, Stallmach, A., additional, Sticherling, M., additional, Stremmel, W., additional, Sure, U., additional, Tacke, F., additional, Vloet, T., additional, Voderholzer, U., additional, von Kodolitsch, Y., additional, Wagenlehner, F., additional, Wahlers, T., additional, Weber, L.T., additional, Weidner, W., additional, Weis-Müller, B.T., additional, Werner, N., additional, Wintergerst, U., additional, Wolf, Gunter, additional, Ziegler, D., additional, Zierz, S., additional, and Zimmermann, Th., additional
- Published
- 2019
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4. Diagnostik und Therapie der Akromegalie: Notwendigkeit der gezielten Überwachung von Komorbiditäten
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Petersenn, S., Christ-Crain, M., Droste, M., Finke, R., Flitsch, J., Kreitschmann-Andermahr, I., Luger, A., Schopohl, J., and Stalla, G.
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- 2017
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5. Long-term treatment of Cushing’s disease with pasireotide: 5-year results from an open-label extension study of a Phase III trial
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Petersenn, S., Salgado, L. R., Schopohl, J., Portocarrero-Ortiz, L., Arnaldi, G., Lacroix, A., Scaroni, C., Ravichandran, S., Kandra, A., and Biller, B. M. K.
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- 2017
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6. Hypothalamus und Hypophyse
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Schopohl, J., Petersenn, S., Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor
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- 2005
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7. NSE and S-100B are not sufficiently predictive of neurologic outcome after therapeutic hypothermia for cardiac arrest
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Zellner, T., Gärtner, R., Schopohl, J., and Angstwurm, M.
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- 2013
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8. Erkrankungen endokriner Drüsen
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Mann, Klaus, Schopohl, J., Petersenn, S., Saller, Bernhard, Janssen, Onno E., Arlt, Wiebke, Zitzmann, Michael, Nieschlag, Eberhard, Wuttke, Wolfgang, Hinney, Bernd, Gärtner, Roland, Schaaf, Ludwig, Stalla, Günter Karl, Pfeilschifter, Johannes, Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor
- Published
- 2003
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9. Kapitel 36 - Hypophysenhinterlappen
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Schopohl, J. and Honegger, J.
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- 2022
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10. Extended treatment of Cushing’s disease with pasireotide: results from a 2-year, Phase II study
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Boscaro, M., Bertherat, J., Findling, J., Fleseriu, M., Atkinson, A. B., Petersenn, S., Schopohl, J., Snyder, P., Hughes, G., Trovato, A., Hu, K., Maldonado, M., and Biller, B. M. K.
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- 2014
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11. The acute effect of a single application of cabergoline on endogenous GH levels in patients with acromegaly on pegvisomant treatment
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Roemmler, J., Steffin, B., Gutt, B., Schneider, H.J., Sievers, C., Bidlingmaier, M., and Schopohl, J.
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- 2010
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12. Local Litholysis of Intrahepatic Calculi
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Draese, K., Schopohl, J., Zöckler, C. E., Martin, S., Swobodnik, W., editor, Soloway, R. D., editor, and Ditschuneit, H., editor
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- 1990
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13. The effect of acute application of pegvisomant alone and in combination with octreotide on endogenous GH levels during a 6-h test in patients with acromegaly on constant pegvisomant treatment
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Roemmler, J., Steffin, B., Gutt, B., Sievers, C., Bidlingmaier, M., and Schopohl, J.
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- 2009
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14. Influence of long-term growth hormone replacement on leptin and ghrelin in GH deficiency before and after glucose load
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Roemmler, J., Kuenkler, M., Otto, B., Arafat, A.M., Bidlingmaier, M., and Schopohl, J.
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- 2009
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15. Hypophysenhinterlappen
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Schopohl, J., primary and Honegger, J., additional
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- 2015
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16. Hypothalamus und Hypophysenvorderlappen
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Schopohl, J., primary and Honegger, J., additional
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- 2015
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17. Elevated incidence of sleep apnoea in acromegaly—correlation to disease activity
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Roemmler, J., Gutt, B., Fischer, R., Vay, S., Wiesmeth, A., Bidlingmaier, M., Schopohl, J., and Angstwurm, M.
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- 2012
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18. Cognitive function in acromegaly: description and brain volumetric correlates
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Sievers, Caroline, Sämann, P. G., Pfister, H., Dimopoulou, C., Czisch, M., Roemmler, J., Schopohl, J., Stalla, G. K., and Zihl, J.
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- 2012
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19. Lethal Generalized Calcinosis and Hypercalcemic Crisis in Primary Hyperparathyroidism
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Pallauf, A., Schopohl, J., Makeschin, M., Kirchner, T., and Reincke, M.
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- 2015
20. Specific behaviour, mood and personality traits may contribute to obesity in patients with craniopharyngioma
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Roemmler-Zehrer, J., Geigenberger, V., Störmann, S., Ising, M., Pfister, H., Sievers, C., Stalla, G. K., and Schopohl, J.
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- 2015
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21. Adverse anthropometric risk profile in biochemically controlled acromegalic patients: comparison with an age- and gender-matched primary care population
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Dimopoulou, C., Sievers, C., Wittchen, H. U., Pieper, L., Klotsche, J., Roemmler, J., Schopohl, J., Schneider, H. J., and Stalla, G. K.
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- 2010
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22. Endogenous estradiol may influence IGF-I levels in acromegalic women treated with pegvisomant
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Roemmler, J., Bidlingmaier, M., and Schopohl, J.
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- 2010
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23. Macroscopic brain architecture changes and white matter pathology in acromegaly: a clinicoradiological study
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Sievers, C., Sämann, P. G., Dose, T., Dimopoulou, C., Spieler, D., Roemmler, J., Schopohl, J., Mueller, M., Schneider, H. J., Czisch, M., Pfister, H., and Stalla, G. K.
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- 2009
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24. Corticotroph tumor progression after bilateral adrenalectomy (Nelson's syndrome): systematic review and expert consensus recommendations
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Reincke, M, Albani, A, Assie, G, Bancos, I, Brue, T, Buchfelder, M, Chabre, O, Ceccato, F, Daniele, A, Detomas, M, Di Dalmazi, G, Elenkova, A, Findling, J, Grossman, AB, Gomez-Sanchez, CE, Heaney, AP, Honegger, J, Karavitaki, N, Lacroix, A, Laws, E R, Losa, M, Murakami, M, Newell-Price, J, Giraldi, FP, Perez-Rivas, LG, Pivonello, R, Rainey, WE, Sbiera, S, Schopohl, J, Stratakis, CA, Theodoropoulou, M, van Rossum, Liesbeth, Valassi, E, Zacharieva, S, Rubinstein, G, Ritzel, K, Reincke, M, Albani, A, Assie, G, Bancos, I, Brue, T, Buchfelder, M, Chabre, O, Ceccato, F, Daniele, A, Detomas, M, Di Dalmazi, G, Elenkova, A, Findling, J, Grossman, AB, Gomez-Sanchez, CE, Heaney, AP, Honegger, J, Karavitaki, N, Lacroix, A, Laws, E R, Losa, M, Murakami, M, Newell-Price, J, Giraldi, FP, Perez-Rivas, LG, Pivonello, R, Rainey, WE, Sbiera, S, Schopohl, J, Stratakis, CA, Theodoropoulou, M, van Rossum, Liesbeth, Valassi, E, Zacharieva, S, Rubinstein, G, and Ritzel, K
- Abstract
Background: Corticotroph tumor progression (CTP) leading to Nelson’s syndrome (NS) is a severe and difficult-to-treat complication subsequent to bilateral adrenalectomy (BADX) for Cushing’s disease. Its characteristics are not well described, and consensus recommendations for diagnosis and treatment are missing. Methods: A systematic literature search was performed focusing on clinical studies and case series (≥5 patients). Definition, cumulative incidence, treatment and long-term outcomes of CTP/NS after BADX were analyzed using descriptive statistics. The results were presented and discussed at an interdisciplinary consensus workshop attended by international pituitary experts in Munich on October 28, 2018. Results: Data covered definition and cumulative incidence (34 studies, 1275 patients), surgical outcome (12 studies, 187 patients), outcome of radiation therapy (21 studies, 273 patients), and medical therapy (15 studies, 72 patients). Conclusions: We endorse the definition of CTP-BADX/NS as radiological progression or new detection of a pituitary tumor on thin-section MRI. We recommend surveillance by MRI after 3 months and every 12 months for the first 3 years after BADX. Subsequently, we suggest clinical evaluation every 12 months and MRI at increasing intervals every 2–4 years (depending on ACTH and clinical parameters). We recommend pituitary surgery as first-line therapy in patients with CTP-BADX/NS. Surgery should be performed before extrasellar expansion of the tumor to obtain complete and long-term remission.
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- 2021
25. Medikamentöse Therapie von Hypophysenerkrankungen
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Gutt, B., Steffin, B., and Schopohl, J.
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- 2005
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26. Autorenverzeichnis
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Domschke, W., primary, Berger, M., additional, Hohenberger, W., additional, Meinertz, T., additional, Vogelmeier, C., additional, Domschke, W., additional, Sauerbruch, T., additional, Kramer, H.J., additional, Müller, S.C., additional, Serve, H., additional, Weber, M.M., additional, Göke, B., additional, Kalden, J.R., additional, Manger, B., additional, Rascher, W., additional, Appenrodt, B., additional, Atta, J., additional, Auernhammer, C., additional, Autenrieth, I.B., additional, Avenhaus, W., additional, Backmund, M., additional, Bausewein, C., additional, Behr, J., additional, Behrens, A., additional, Berner, R., additional, Berr, F., additional, Blank, N., additional, Blind, E., additional, Bockhorn, M., additional, Bokemeyer, D., additional, Böhm, M., additional, Bönner, G., additional, Borasio, G.D., additional, Bork, K., additional, Braun, J., additional, Bruch, H.-P., additional, Brümmendorf, T.H., additional, Brunnberg, U., additional, Brüwer, M., additional, Büchler, M.W., additional, Detter, C., additional, Diederich, S., additional, Diehm, C., additional, Distler, J., additional, Domagk, D., additional, Dörner, T., additional, Dörr, H.-G., additional, Dralle, H., additional, Dreyling, M., additional, Ehlebracht-König, I., additional, Ell, C., additional, Enzensberger, W., additional, Epple, H.-J., additional, Fassnacht, M., additional, Feußner, H., additional, Fiegel, P., additional, Fisang, C., additional, Filipas, D., additional, Fischbach, W., additional, Flamme, C.H., additional, Floege, J., additional, Fölsch, U.R., additional, Fottner, C., additional, Frank, W., additional, Frey, N., additional, Friese, K., additional, Frilling, A., additional, Fröhner, M., additional, Frühmorgen, P., additional, Galle, P.R., additional, Geidel, S., additional, Genth, E., additional, Gingelmaier, A., additional, Goebel, F.-D., additional, Gökbuget, N., additional, Göke, R., additional, Grabitz, K., additional, Grünke, M., additional, Hahner, S., additional, Handrick, W., additional, Hasslacher, C., additional, Heidbreder, E., additional, Heindel, W., additional, Heinemann, V., additional, Heitmann, J., additional, Heiß, H.W., additional, Hof, H., additional, Hering, L., additional, Hiller, E., additional, Hirner, A., additional, Hofmann, W.-K., additional, Holler, E., additional, Hölscher, A.H., additional, Holtmann, G., additional, Hölzen, J., additional, Honegger, J., additional, Hörle, S., additional, Hörmann, K., additional, Hörmann, R., additional, Hornke, I., additional, Huber, R.M., additional, Hübner, J., additional, Hummel, R., additional, Irmscher, S., additional, Jelinek, T., additional, Jonas, S., additional, Jost, E., additional, Jung, H.H., additional, Kahaly, G.J., additional, Karaus, M., additional, Katsoulis, S., additional, Katus, H., additional, Kessler, H.P., additional, Kiehne, K., additional, Kiess, W., additional, Kindermann, M., additional, von Kodolitsch, Y., additional, Köhler, H., additional, Köhler, L., additional, Köhler, M., additional, Kohne, E., additional, Kolb, H.-J., additional, Köninger, J., additional, Koop, K., additional, Köster, R., additional, Kötter, I., additional, Kramer, H.J.J., additional, Kremer, B., additional, Kroll, P., additional, Kuipers, J.G., additional, Lammert, F., additional, Langer, M., additional, Laukötter, M., additional, Lehnert, H., additional, Lembcke, B., additional, Lerch, M.M., additional, Liebe, S., additional, Lieber, A., additional, Loddenkemper, R., additional, Löhr, M., additional, Lorenz, H.-M., additional, Lorenz, J., additional, Löscher, T., additional, Luster, M., additional, Lux, G., additional, Mann, K., additional, Mayerle, J., additional, Merle, U., additional, Meyer, H.-J., additional, Möbius, C., additional, Moehler, M., additional, Mönnikes, H., additional, Mössner, J., additional, Müller, S.A., additional, Musholt, T.J., additional, Nattermann, J., additional, Neubrand, M., additional, Neuhaus, P., additional, Neundörfer, B., additional, Nicolai, T., additional, Nolde, J., additional, Olschewski, H., additional, Ostermeyer, J., additional, Ott, C., additional, Pahernik, S., additional, Pankratius, U., additional, Parhofer, K.G., additional, Passlick, B., additional, Pech, O., additional, Pfaffenbach, B., additional, Pfeiffer, T., additional, Pilatz, A., additional, Pohle, T., additional, Pohl-Koppe, A., additional, Ponto, Katharina A., additional, Prange, H., additional, Pruß, A., additional, Rädle, J., additional, Rauch, B., additional, Raue, F., additional, Reichel, C., additional, Reindl, C., additional, Reißfelder, C., additional, Rendl, Dipl.-Phys. J., additional, Rietschel, E., additional, Rijcken, E., additional, Roos, R., additional, Rudofsky†, G., additional, Samtleben, W., additional, Sandmann, W., additional, Sauter, G., additional, Schaal, K.P., additional, Schaefer, J.R., additional, Schäfer-Graf, U., additional, Schepp, W., additional, Schlemmer, M., additional, Schliep, S., additional, Schmidt, H., additional, Schmied, B., additional, Schmiegel, W., additional, Schießl, A., additional, Schmid, A., additional, Schneider, A., additional, Schneider, T., additional, Schölmerich, J., additional, Scholz, H., additional, Schönermarck, U., additional, Schopohl, J., additional, Schrezenmeier, H., additional, Schulze-Koops, H., additional, Schuppan, D., additional, Schuster, V., additional, Schüßler, G., additional, Schwandner, O., additional, Schwarz, T.F., additional, Secknus, R., additional, Senninger, N., additional, Sezer, O., additional, Simmen, B.R., additional, Spengler, U., additional, Stabenow-Lohbauer, U., additional, Stebler, R., additional, Steven, D., additional, Sticherling, M., additional, Strauch, U., additional, Stremmel, C., additional, Stremmel, W., additional, Stuck, B.A., additional, Stürz, H., additional, Taube, C., additional, Thulesius, O., additional, Thurau, K., additional, Thüroff, J.W., additional, Tomiak, C., additional, Uhl, W., additional, Vallböhmer, D., additional, Vogel, T., additional, von den Driesch, P., additional, Wagenlehner, F.M.E., additional, Wagner, A., additional, Wagner, U., additional, Weber, K., additional, Weidner, W., additional, Weinke, T., additional, Weis-Müller, B.T., additional, Weiß, M., additional, Willems, S., additional, Wintergerst, U., additional, Wirth, M., additional, Wolkersdörfer, G.W., additional, and Zeitz, M., additional
- Published
- 2011
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27. Metabolische Notfälle
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Gärtner, R. and Schopohl, J.
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- 2000
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28. Effects on metabolic variables after 12-month treatment with a new once-a-week sustained-release recombinant growth hormone (GH: LB03002) in patients with GH deficiency
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Roemmler, J., Gockel, A., Otto, B., Bidlingmaier, M., and Schopohl, J.
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- 2012
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29. Ein 21-jähriger Patient mit einem Mikroadenom der Hypophyse und einer neu aufgetretenen Gynäkomastie
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Tschöp, M., Pflaum, C. -D., Strasburger, C. J., Gärtner, R., and Schopohl, J.
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- 1999
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30. Fractionated radiotherapy and radiosurgery in acromegaly: analysis of 352 patients from the German Acromegaly Registry
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Knappe, U J, primary, Petroff, D, additional, Quinkler, M, additional, Schmid, S M, additional, Schöfl, C, additional, Schopohl, J, additional, Stieg, M R, additional, Tönjes, A, additional, and _, _, additional
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- 2020
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31. Pasireotide (SOM230) Demonstrates Efficacy and Safety in Patients with Acromegaly: A Randomized, Multicenter, Phase II Trial
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Petersenn, S., Schopohl, J., Barkan, A., Mohideen, P., Colao, A., Abs, R., Buchelt, A., Ho, Y. Y., Hu, K., Farrall, A. J., Melmed, S., and Biller, B. M. K.
- Published
- 2010
32. Kapitel 50 - Hypophysenhinterlappen
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Schopohl, J. and Honegger, J.
- Published
- 2019
- Full Text
- View/download PDF
33. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. 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A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. 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- 1994
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34. Ectopic secretion of growth hormone-releasing hormone in man
- Author
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Losa, Marco, Schopohl, J., and von Werder, K.
- Published
- 1993
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- View/download PDF
35. One-year follow-up of patients with acromegaly treated with fixed or titrated doses of lanreotide Autogel®
- Author
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Caron, Ph., Bex, M., Cullen, D. R., Feldt-Rasmussen, U., Alfonso, A. M. Pico, Pynka, S., Racz, K., Schopohl, J., Tabarin, A., and Valimaki, M. J.
- Published
- 2004
36. Long-term treatment with SMS 201–995 in resistant acromegaly: Effectiveness of high doses and continuous subcutaneous infusion
- Author
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Mehltretter, G., Heinz, S., Schopohl, J., von Werder, K., and Müller, O. A.
- Published
- 1991
- Full Text
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37. Comparison of octreotide acetate LAR and lanreotide SR in patients with acromegaly
- Author
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Chanson, P, Boerlin, V, Ajzenberg, C, Bachelot, Y, Benito, P, Bringer, J, Caron, P, Charbonnel, B, Cortet, C, Delemer, B, Escobar-Jiménez, F, Foubert, L, Gaztambide, S, Jockenhoevel, F, Kuhn, J. M, Leclere, J, Lorcy, Y, Perlemuter, L, Prestele, H, Roger, P, Rohmer, V, Santen, R, Sassolas, G, Scherbaum, W. A, Schopohl, J, Torres, E, Varela, C, Villamil, F, and Webb, S. M
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- 2000
38. MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post hoc analysis
- Author
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Bonneville, Fabrice, primary, Rivière, Louis-David, additional, Petersenn, Stephan, additional, Bevan, John S, additional, Houchard, Aude, additional, Sert, Caroline, additional, Caron, Philippe J, additional, _, _, additional, Van, Gaal L, additional, Marek, J, additional, Nuutila, P, additional, Välimäki, M, additional, Ajzenberg, C, additional, Borson-Chazot, F, additional, Brue, T, additional, Caron, P, additional, Chabre, O, additional, Chanson, P, additional, Rudelli, C Cortet, additional, Delemer, B, additional, Kuhn, J-M, additional, Tabarin, A, additional, Badenhoop, K, additional, Berg, C, additional, Petersenn, S, additional, Schöfl, C, additional, Schopohl, J, additional, Cannavò, S, additional, Colao, A, additional, De Marinis, L, additional, Stades, A, additional, van der Lely, A J, additional, Kadıoğlu, P, additional, Bevan, J S, additional, Flanagan, D, additional, and Trainer, P, additional
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- 2019
- Full Text
- View/download PDF
39. Symposium E : Hypothalamische und gastrointestinale Neuropeptide und Neurotransmitter
- Author
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Pfeiffer, E. F., Voigt, K. H., Del Pozo, E., Peters, F., Heredia, E., Breckwoldt, M., Schopohl, J., Stalla, G. K., Werder, K., Losa, M., Bock, L., Müller, O. A., Schusdziarra, V., Creutzfeld, W., Usadel, K. H., Miehlke, Klaus, editor, and Bergmann, J. F.
- Published
- 1984
- Full Text
- View/download PDF
40. SMS 201–995 (Sandostatin®) Treatment of Therapy-Resistant Acromegaly
- Author
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Schopohl, J., Müller, O. A., von Werder, K., and Lamberts, Steven W. J., editor
- Published
- 1988
- Full Text
- View/download PDF
41. Decision Analysis of Treatment Options in Acromegaly
- Author
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von Werder, K., Fahlbusch, R., Losa, M., Oeckler, R., Pichl, J., Schopohl, J., Robbins, Richard J., editor, and Melmed, Shlomo, editor
- Published
- 1987
- Full Text
- View/download PDF
42. M 4 - Hypophysenhinterlappen
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Schopohl, J. and Honegger, J.
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- 2015
- Full Text
- View/download PDF
43. M 1 - Hypothalamus und Hypophysenvorderlappen
- Author
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Schopohl, J. and Honegger, J.
- Published
- 2015
- Full Text
- View/download PDF
44. Effects of lanreotide Autogel primary therapy on symptoms and quality-of-life in acromegaly: data from the PRIMARYS study
- Author
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Caron, Philippe J, Bevan, John S., Petersenn, Stephan, Houchard, Aude, Sert, Caroline, Webb, Susan M., Van Gaal, L, Marek, J, Nuutila, P, Välimäki, M, Ajzenberg, C, Borson Chazot, F, Brue, T, Caron, P, Chabre, O, Chanson, P, Rudelli, C, Delemer, B, Kuhn, J, Tabarin, A, Badenhoop, K, Berg, C, Petersenn, S, Schöfl, C, Schopohl, J, Cannavo', Salvatore, Colao, A, De Marinis, L, Stades, A, van der Lely, Aj, Kadıoğlu, Tp, Bevan, Js, Flanagan, D, and Trainer, P.
- Subjects
Adult ,Male ,Quality of life ,medicine.medical_specialty ,Post hoc ,Health Status ,Injections, Subcutaneous ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Signs and symptoms ,Peptides, Cyclic ,Primary therapy ,Article ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Acromegaly, Lanreotide Autogel, Quality of life, Symptoms, Endocrinology, Endocrinology, Diabetes and Metabolism ,Surveys and Questionnaires ,Acromegaly ,medicine ,Humans ,In patient ,Dosage Forms ,business.industry ,Lanreotide Autogel ,Middle Aged ,medicine.disease ,Diabetes and Metabolism ,030220 oncology & carcinogenesis ,Symptoms ,Primary treatment ,Female ,business ,Somatostatin ,Gels - Abstract
Purpose To evaluate the effects of lanreotide Autogel on patient-reported outcomes and association with biochemical control, using PRIMARYS data. Methods PRIMARYS was a 1-year, open-label study of lanreotide Autogel (Depot in USA) 120 mg every 4 weeks in 90 treatment-naïve patients with acromegaly. Symptoms were assessed using Patient-assessed Acromegaly Symptom Questionnaire (PASQ) and health-related quality of life (HRQoL) using the AcroQoL questionnaire. Correlations between PASQ and AcroQoL scores, and between PASQ/AcroQoL and growth hormone (GH)/insulin-like growth factor-1 (IGF-1) levels were also evaluated (post hoc). Results Acromegaly symptoms and HRQoL significantly improved from week 12 to week 48, with modest correlations at week 48 between PASQ total score (R = –0.55, p 50 % of baseline standard deviation) in PASQ total score and >40 % achieved a MID in AcroQoL global score (post hoc). Changes in PASQ scores were similar in biochemically controlled (GH levels ≤2.5 μg/L and normal IGF-1 levels) and uncontrolled groups, while changes in global and psychological AcroQoL scores were greater in the controlled group. There was no correlation between changes in PASQ or AcroQoL scores and changes in GH or IGF-1 levels. Conclusions Primary treatment with lanreotide Autogel over 1 year was associated with rapid and sustained improvements in clinical signs and symptoms and HRQoL in patients with acromegaly. Improvements in HRQoL, but not symptoms, were greater in those achieving biochemical control (ClinicalTrials.gov: NCT00690898; EudraCT: 2007–000155–34). Electronic supplementary material The online version of this article (doi:10.1007/s11102-015-0693-y) contains supplementary material, which is available to authorized users.
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- 2016
45. Diagnostische Kriterien für die Indikation zur Wachstumshormon-Substitution bei Erwachsenen
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Schopohl J, Oertel H, Strasburger Cj, and Kann P
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business.industry ,Medicine ,General Medicine ,business - Published
- 2008
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46. Pasireotide versus continued treatment with octreotide or lanreotide in patients with inadequately controlled acromegaly (PAOLA): A randomised, phase 3 trial
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Gadelha, Mônica R, Bronstein, Marcello D, Brue, Thierry, Coculescu, Mihail, Fleseriu, Maria, Guitelman, Mirtha, Pronin, Vyacheslav, Raverot, Gérald, Shimon, Ilan, Lievre, Kayo Kodama, Fleck, Juergen, Aout, Mounir, Pedroncelli, Alberto M, Colao, Annamaria, Abreu, A, Abucham Filho JZ, Araujo, L, Barkan, A, Bender G, Bex M, Bolanowski, M, Bollerslev, J, Cannavo', Salvatore, Caron, P, Chanson, P, Çomlekçi, A, De Marinis, L, Deyneli, O, dos Santos Nunes, V, Drui, D, Faria, Ms, Ferone, D, Flanagan, D, Ghigo, E, Houde, G, Leonova, Nv, Mayberg, M, Mcphaul, Mj, Mendes, H, Montenegro, Rm, Nasser, T, Obiols Alfons, G, Pico Alfonso, A, Raef, H, Rozhinskaya, Ly, Sari, R, Schoefl, C, Schopohl, J, Sowinski, J, Suplotova, L, Sworczak, K, Tabarin, A, Tovar, H, Venegas Moreno, E, Verges, B., Gadelha, Mônica R, Bronstein, Marcello D, Brue, Thierry, Coculescu, Mihail, Fleseriu, Maria, Guitelman, Mirtha, Pronin, Vyacheslav, Raverot, Gérald, Shimon, Ilan, Lievre, Kayo Kodama, Fleck, Juergen, Aout, Mounir, Pedroncelli, Alberto M, and Colao, Annamaria
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Octreotide ,Lanreotide ,Gastroenterology ,Peptides, Cyclic ,law.invention ,chemistry.chemical_compound ,Young Adult ,Endocrinology ,Randomized controlled trial ,law ,Internal medicine ,Acromegaly ,80 and over ,Internal Medicine ,Medicine ,Humans ,Insulin-Like Growth Factor I ,Aged ,Aged, 80 and over ,Cyclic ,Intention-to-treat analysis ,business.industry ,Human Growth Hormone ,Medicine (all) ,Middle Aged ,medicine.disease ,Pasireotide ,Surgery ,Somatostatin ,Treatment Outcome ,chemistry ,Female ,Pegvisomant ,business ,Peptides ,medicine.drug - Abstract
BACKGROUND: Many patients with acromegaly do not achieve biochemical control despite receiving high doses of the first-generation somatostatin analogues octreotide or lanreotide. In the PAOLA trial, we aimed to assess the efficacy and safety of two different doses of the somatostatin analogue pasireotide long-acting release compared with active control (octreotide or lanreotide) in patients with inadequately controlled acromegaly. METHODS: In a multicentre, randomised, phase 3 trial, we enrolled eligible patients aged 18 years or older with acromegaly who were inadequately controlled (5-point, 2 h mean growth hormone concentration >2·5 μg/L and insulin-like growth factor 1 [IGF-1] concentration >1·3 times the upper normal limit) and had received 30 mg octreotide long-acting repeatable or 120 mg lanreotide (Somatuline Autogel; Ipsen, UK) as monotherapy for 6 months or longer. We randomly assigned patients in a 1:1:1 ratio with an interactive voice-web response system to receive 40 mg pasireotide long-acting release once every 28 days for 24 weeks, 60 mg pasireotide long-acting release once every 28 days for 24 weeks, or continued treatment with octreotide or lanreotide (active control). Patients were stratified according to previous treatment (octreotide or lanreotide) and growth hormone concentrations at screening (2·5-10 μg/L and >10 μg/L). Patients and study investigators were not masked to study drug assignment but were masked to pasireotide dose allocation. The primary endpoint was number of patients achieving biochemical control, defined as mean growth hormone concentration less than 2·5 μg/L and normalised IGF-1 concentration. Efficacy analyses were based on intention to treat. This trial is registered with ClinicalTrials.gov, number NCT01137682. FINDINGS: Between Dec 17, 2010, and Aug 6, 2012, 198 patients were enrolled and randomly assigned to pasireotide 40 mg (n=65), pasireotide 60 mg (n=65), or active control (n=68) groups. At 24 weeks, ten (15%) patients in the pasireotide 40 mg group and 13 (20%) patients in the pasireotide 60 mg group achieved biochemical control, compared with no patients in the active control group (absolute difference from control group 15·4%, 95% CI 7·6-26·5, p=0·0006 for pasireotide 40 mg group, 20·0%, 11·1-31·8, p
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- 2014
47. Tumor shrinkage with lanreotide Autogel 120 mg as primary therapy in acromegaly : results of a prospective multicenter clinical trial
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Caron, Pj, Bevan, Js, Petersenn, S, Flanagan, D, Tabarin, A, Prévost, G, Maisonobe, P, Clermont, A, Van Gaal Luc, L, Marek, J, Nuutila, P, Välimäki, M, Ajzenberg, C, Borson Chazot, F, Brue, T, Caron, P, Chabre, O, Chanson, P, Rudelli, C, Delemer, B, Kuhn, Jm, Badenhoop, K, Berg, C, Schöfl, C, Schopohl, J, Cannavo', Salvatore, Colao, A, De Marinis, L, Stades, A, Van der Lely, A, Kadioğlu, P, Bevan, J, Trainer, P., and Berg, Christian (Beitragende*r)
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Adenoma ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,acromegaly ,somatostatin analogs ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Clinical Biochemistry ,Medizin ,Context (language use) ,Lanreotide ,Biochemistry ,Peptides, Cyclic ,chemistry.chemical_compound ,Young Adult ,Endocrinology ,Internal medicine ,Acromegaly ,medicine ,Clinical endpoint ,Humans ,Neoadjuvant therapy ,Aged ,Intention-to-treat analysis ,business.industry ,Surrogate endpoint ,Endocrine Care ,Biochemistry (medical) ,Middle Aged ,medicine.disease ,Neoadjuvant Therapy ,Tumor Burden ,Clinical trial ,Treatment Outcome ,chemistry ,Female ,Growth Hormone-Secreting Pituitary Adenoma ,business ,Somatostatin ,Gels - Abstract
Context: Methodological shortcomings often compromise investigations into the effects of primary somatostatin-analog treatment on tumor size in acromegaly. There are also limited data for the long-acting lanreotide formulation. Objective: The aim of the study was to better characterize the effects of primary lanreotide Autogel treatment on tumor size in patients with GH-secreting macroadenomas. Design: PRIMARYS was a 48-week, multicenter, open-label, single-arm study. Setting: The study was conducted at specialist endocrine centers. Patients: Treatment-naïve acromegalic patients with GH-secreting macroadenomas participated in the study. Intervention: Lanreotide Autogel 120 mg was administered sc every 28 days (without dose titration). Outcome Measures: The primary endpoint was the proportion of patients with clinically significant (≥20%) tumor volume reduction (TVR) at week 48/last post-baseline value available using central assessments from three readers. The null hypothesis (H0) for the primary endpoint was that the proportion with TVR was ≤55%. Secondary endpoints included: TVR at other time points, GH and IGF-1, acromegalic symptoms, quality of life (QoL), and safety. Results: Sixty-four of 90 (71.1%) patients completed the study. Clinically significant TVR at 48 weeks/last post-baseline value available was achieved by 62.9% (95% confidence interval, 52.0, 72.9) of 89 patients in the primary analysis (intention-to-treat population; H0 not rejected) and 71.9–75.3% in sensitivity (n = 89) and secondary analyses (n = 63) (H0 rejected). At 12 weeks, 54.1% had clinically significant TVR. Early and sustained improvements also occurred in GH and IGF-1, acromegalic symptoms, and QoL. No patients withdrew due to gastrointestinal intolerance. Conclusions: Primary treatment with lanreotide Autogel, administered at 120 mg (highest available dose) without dose titration, in patients with GH-secreting macroadenomas provides early and sustained reductions in tumor volume, GH and IGF-1, and acromegalic symptoms, and improves QoL.
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- 2014
48. Combined pituitary function-test with four hypothalamic releasing hormones
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Schopohl, J., Losa, M., König, A., Müller, O. A., Stalla, G. K., and von Werder, K.
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- 1986
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49. Effects of theophylline infusion on the growth hormone (GH) and prolactin response to GH-releasing hormone administration in acromegaly
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Losa, M., Alba-Lopez, J., Schopohl, J., Sobiesczcyk, S., Chiodini, P. G., Müller, O. A., and von Werder, K.
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- 1988
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50. Stimulation of growth hormone secretion with human growth hormone releasing factors (GRF1–44, GRF1–40, GRF1–29) in normal subjects
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Losa, M., Schopohl, J., Müller, O. A., and von Werder, K.
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- 1984
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