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5. Usefulness of High Sensitivity Troponin T to Predict Long-Term Left Ventricular Dysfunction After ST-Elevation Myocardial Infarction

Author

Mohammad, Moman A., Koul, Sasha, Lønborg, Jacob Thomsen, Nepper-Christensen, Lars, Høfsten, Dan E., Ahtarovski, Kiril A., Bang, Lia E., Helqvist, Steffen, Kyhl, Kasper, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Holmvang, Lene, Schoos, Mikkel Malby, Göransson, Christoffer, Engstrøm, Thomas, and Erlinge, David

Published
2020
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6. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3–PRIMULTI Cardiac Magnetic Resonance Substudy

Author

Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, and Engstrøm, Thomas

Published
2019
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7. Patterns and Impact of Dual Antiplatelet Cessation on Cardiovascular Risk After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes

Author

Schoos, Mikkel, Power, David, Baber, Usman, Sartori, Samantha, Claessen, Bimmer, Camaj, Anton, Steg, Philippe, Ariti, Cono, Weisz, Giora, Witzenbichler, Bernhard, Henry, Timothy, Cohen, David, Antoniucci, David, Krucoff, Mitchell, Hermiller, James, Gibson, Charles, Chieffo, Alaide, Moliterno, David, Colombo, Antonio, Pocock, Stuart, Dangas, George, and Mehran, Roxana

Published
2019
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10. Causes, Timing, and Impact of Dual Antiplatelet Therapy Interruption for Surgery (from the Patterns of Non-adherence to Anti-platelet Regimens In Stented Patients Registry)

Author

Schoos, Mikkel, Chandrasekhar, Jaya, Baber, Usman, Bhasin, Aarti, Sartori, Samantha, Aquino, Melissa, Vogel, Birgit, Farhan, Serdar, Sorrentino, Sabato, Kini, Annapoorna, Kruckoff, Mitchell, Moliterno, David, Henry, Timothy D., Weisz, Giora, Gibson, C. Michael, Iakovou, Ioannis, Colombo, Antonio, Steg, P. Gabriel, Witzenbichler, Bernhard, Chieffo, Alaide, Cohen, David, Stuckey, Thomas, Ariti, Cono, Dangas, George, Pocock, Stuart, and Mehran, Roxana

Published
2017
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12. Impact of Hemoglobin A1c Levels on Residual Platelet Reactivity and Outcomes After Insertion of Coronary Drug-Eluting Stents (from the ADAPT-DES Study)

Author

Schoos, Mikkel M., Dangas, George D., Mehran, Roxana, Kirtane, Ajay J., Yu, Jennifer, Litherland, Claire, Clemmensen, Peter, Stuckey, Thomas D., Witzenbichler, Bernhard, Weisz, Giora, Rinaldi, Michael J., Neumann, Franz-Josef, Metzger, D. Christopher, Henry, Timothy D., Cox, David A., Duffy, Peter L., Brodie, Bruce R., Mazzaferri, Ernest L., Jr., Maehara, Akiko, and Stone, Gregg W.

Published
2016
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14. Balancing the Risk of Bleeding and Stroke in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention (from the AVIATOR Registry)

Author

Mennuni, Marco G., Halperin, Jonathan L., Bansilal, Sameer, Schoos, Mikkel M., Theodoropoulos, Kleanthis N., Meelu, Omar A., Sartori, Samantha, Giacoppo, Daniele, Bernelli, Chiara, Moreno, Pedro R., Krishnan, Prakash, Baber, Usman, Lucarelli, Carla, Dangas, George D., Sharma, Samin K., Kini, Annapoorna S., Tamburino, Corrado, Chieffo, Alaide, Colombo, Antonio, Presbitero, Patrizia, and Mehran, Roxana

Published
2015
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17. Polypill Strategy in Secondary Cardiovascular Prevention

Author

Castellano, Jose M., primary, Pocock, Stuart J., additional, Bhatt, Deepak L., additional, Quesada, Antonio J., additional, Owen, Ruth, additional, Fernandez-Ortiz, Antonio, additional, Sanchez, Pedro L., additional, Marin Ortuño, Francisco, additional, Vazquez Rodriguez, Jose M., additional, Domingo-Fernández, Alexandra, additional, Lozano, Iñigo, additional, Roncaglioni, Maria C., additional, Baviera, Marta, additional, Foresta, Andreana, additional, Ojeda-Fernandez, Luisa, additional, Colivicchi, Furio, additional, Di Fusco, Stefania A., additional, Doehner, Wolfram, additional, Meyer, Antje, additional, Schiele, François, additional, Ecarnot, Fiona, additional, Linhart, Aleš, additional, Lubanda, Jean-Claude, additional, Barczi, Gyorgy, additional, Merkely, Bela, additional, Ponikowski, Piotr, additional, Kasprzak, Marta, additional, Fernandez Alvira, Juan M., additional, Andres, Vicente, additional, Bueno, Hector, additional, Collier, Timothy, additional, Van de Werf, Frans, additional, Perel, Pablo, additional, Rodriguez-Manero, Moises, additional, Alonso Garcia, Angeles, additional, Proietti, Marco, additional, Schoos, Mikkel M., additional, Simon, Tabassome, additional, Fernandez Ferro, Jose, additional, Lopez, Nicolas, additional, Beghi, Ettore, additional, Bejot, Yannick, additional, Vivas, David, additional, Cordero, Alberto, additional, Ibañez, Borja, additional, and Fuster, Valentin, additional

Published
2022
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22. Association Between Early Q Waves and Reperfusion Success in Patients With ST-Segment–Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: A Cardiac Magnetic Resonance Imaging Study

Author

Topal, Divan Gabriel, Lønborg, Jacob, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Helqvist, Steffen, Holmvang, Lene, Pedersen, Frants, Clemmensen, Peter, Saünamaki, Kari, Jørgensen, Erik, Kyhl, Kasper, Ghotbi, Ali, Schoos, Mikkel Malby, Göransson, Christoffer, Bertelsen, Litten, Høfsten, Dan, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, and Engstrøm, Thomas

Published
2017
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23. Usefulness of Preprocedure High-Sensitivity C-Reactive Protein to Predict Death, Recurrent Myocardial Infarction, and Stent Thrombosis According to Stent Type in Patients With ST-Segment Elevation Myocardial Infarction Randomized to Bare Metal or Drug-Eluting Stenting During Primary Percutaneous Coronary Intervention

Author

Schoos, Mikkel Malby, Kelbæk, Henning, Kofoed, Klaus F., Køber, Lars, Kløvgaard, Lene, Helqvist, Steffen, Engstrøm, Thomas, Saunamäki, Kari, Jørgensen, Erik, Holmvang, Lene, and Clemmensen, Peter

Published
2011
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27. Ischemia From Nonculprit Stenoses Is Not Associated With Reduced Culprit Infarct Size in Patients with ST-Segment–Elevation Myocardial Infarction

Author

Ekström, Kathrine, primary, Nielsen, Julie V.W., additional, Nepper-Christensen, Lars, additional, Ahtarovski, Kiril A., additional, Kyhl, Kasper, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Ghotbi, Adam A., additional, Kelbæk, Henning, additional, Høfsten, Dan E., additional, Køber, Lars, additional, Schoos, Mikkel M., additional, Vejlstrup, Niels, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2021
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28. Impact of age on reperfusion success and long-term prognosis in ST-segment elevation myocardial infarction – A cardiac magnetic resonance imaging study

Author

Gabriel Topal, Divan, primary, Aleksov Ahtarovski, Kiril, additional, Lønborg, Jacob, additional, Høfsten, Dan, additional, Nepper-Christensen, Lars, additional, Kyhl, Kasper, additional, Schoos, Mikkel, additional, Ghotbi, Adam Ali, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Holmvang, Lene, additional, Helqvist, Steffen, additional, Pedersen, Frants, additional, Schnabel, Renate, additional, Køber, Lars, additional, Kelbæk, Henning, additional, Vejlstrup, Niels, additional, Engstrøm, Thomas, additional, and Clemmensen, Peter, additional

Published
2021
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31. Fractional flow reserve-guided PCI in patients with and without left ventricular hypertrophy: a DANAMI-3-PRIMULTI substudy

Author

Sabbah, Muhammad, primary, Nepper-Christensen, Lars, additional, Lønborg, Jacob, additional, Helqvist, Steffen, additional, Køber, Lars, additional, Høfsten, Dan Eik, additional, Ahtarovski, Kiril Aleksov, additional, Göransson, Christoffer, additional, Kyhl, Kasper, additional, Schoos, Mikkel Malby, additional, Vejlstrup, Niels, additional, Kelbæk, Henning, additional, and Engstrøm, Thomas, additional

Published
2020
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32. Infarct size following loading with Ticagrelor/Prasugrel versus Clopidogrel in ST-segment elevation myocardial infarction

Author

Sabbah, Muhammad, primary, Nepper-Christensen, Lars, additional, Køber, Lars, additional, Høfsten, Dan Eik, additional, Ahtarovski, Kiril Aleksov, additional, Göransson, Christoffer, additional, Kyhl, Kasper, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel Malby, additional, Sadjadieh, Golnaz, additional, Kelbæk, Henning, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2020
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35. Clinical outcome following late reperfusion with percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Author

Nepper-Christensen, Lars, primary, Lønborg, Jacob, additional, Høfsten, Dan Eik, additional, Sadjadieh, Golnaz, additional, Schoos, Mikkel Malby, additional, Pedersen, Frants, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Haahr-Pedersen, Sune, additional, Flensted Lassen, Jens, additional, Køber, Lars, additional, Holmvang, Lene, additional, and Engstrøm, Thomas, additional

Published
2020
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36. Myocardial damage after ST-segment elevation myocardial infarction by use of bivalirudin or heparin: a DANAMI-3 substudy

Author

Schoos, Mikkel M., primary, Nepper-Christensen, Lars, additional, Ahtarovski, Kiril Aleksov, additional, Kyhl, Kasper, additional, Göransson, Christoffer, additional, Holmvang, Lene, additional, Kelbæk, Henning, additional, Helqvist, Steffen, additional, Høfsten, Dan Eik, additional, Køber, Lars, additional, Vejlstrup, Niels, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2020
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37. Sub-acute cardiac magnetic resonance to predict irreversible reduction in left ventricular ejection fraction after ST-segment elevation myocardial infarction: A DANAMI-3 sub-study

Author

Alzuhairi, Karam Sadoon, primary, Lønborg, Jacob, additional, Ahtarovski, Kiril Aleksov, additional, Nepper-Christensen, Lars, additional, Kyhl, Kasper, additional, Lassen, Jens F., additional, Sørensen, Rikke, additional, Joshi, Francis, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel, additional, Goransson, Christoffer, additional, Bertelsen, Litten, additional, Helqvist, Steffen, additional, Holmvang, Lene, additional, Jørgensen, Erik, additional, Pedersen, Frants, additional, Tilsted, Hans-Henrik, additional, Høfsten, Dan, additional, Køber, Lars, additional, Kelbæk, Henning, additional, Vejlstrup, Niels, additional, and Engstrøm, Thomas, additional

Published
2020
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38. Impact of Multiple Myocardial Scars Detected by CMR in Patients Following STEMI

Author

Ekström, Kathrine, primary, Nepper-Christensen, Lars, additional, Ahtarovski, Kiril A., additional, Kyhl, Kasper, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Ghotbi, Adam A., additional, Kelbæk, Henning, additional, Helqvist, Steffen, additional, Høfsten, Dan E., additional, Køber, Lars, additional, Schoos, Mikkel M., additional, Vejlstrup, Niels, additional, Lønborg, Jacob, additional, and Engstrøm, Thomas, additional

Published
2019
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39. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease:A DANAMI-3–PRIMULTI Cardiac Magnetic Resonance Substudy

Author

Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, and Engstrøm, Thomas

Subjects
ST-segment elevation myocardial infarction, cardiovascular magnetic resonance, complete revascularization, acute myocardial infarction, cardiovascular diseases, cardiac function, cardiac remodeling, randomization, primary percutaneous coronary intervention, randomized study, culprit lesion
Abstract

Objectives: The aim of this study was to evaluate the effect of fractional flow reserve (FFR)–guided revascularization compared with culprit-only percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) on infarct size, left ventricular (LV), function, LV remodeling, and the presence of nonculprit infarctions. Background: Patients with STEMI with multivessel disease might have improved clinical outcomes after complete revascularization compared with PCI of the infarct-related artery only, but the impact on infarct size, LV function, and remodeling as well as the risk for periprocedural infarction are unknown. Methods: In this substudy of the DANAMI-3 (Third Danish Trial in Acute Myocardial Infarction)–PRIMULTI (Primary PCI in Patients With ST-Elevation Myocardial Infarction and Multivessel Disease: Treatment of Culprit Lesion Only or Complete Revascularization) randomized trial, patients with STEMI with multivessel disease were randomized to receive either complete FFR-guided revascularization or PCI of the culprit vessel only. The patients underwent cardiac magnetic resonance imaging during index admission and at 3-month follow-up. Results: A total of 280 patients (136 patients with infarct-related and 144 with complete FFR-guided revascularization) were included. There were no differences in final infarct size (median 12% [interquartile range: 5% to 19%] vs. 11% [interquartile range: 4% to 18%]; p = 0.62), myocardial salvage index (median 0.71 [interquartile range: 0.54 to 0.89] vs. 0.66 [interquartile range: 0.55 to 0.87]; p = 0.49), LV ejection fraction (mean 58 ± 9% vs. 59 ± 9%; p = 0.39), and LV end-systolic volume remodeling (mean 7 ± 22 ml vs. 7 ± 19 ml; p = 0.63). New nonculprit infarction occurring after the nonculprit intervention was numerically more frequent among patients treated with complete revascularization (6 [4.5%] vs. 1 [0.8%]; p = 0.12). Conclusions: Complete FFR-guided revascularization in patients with STEMI and multivessel disease did not affect final infarct size, LV function, or remodeling compared with culprit-only PCI.

Published
2019

42. Clinical outcome following late reperfusion with percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Author

Nepper-Christensen, Lars, Lønborg, Jacob, Høfsten, Dan Eik, Sadjadieh, Golnaz, Schoos, Mikkel Malby, Pedersen, Frants, Jørgensen, Erik, Kelbæk, Henning, Haahr-Pedersen, Sune, Flensted Lassen, Jens, Køber, Lars, Holmvang, Lene, and Engstrøm, Thomas

Abstract

Background: Up to 40% of patients with ST-segment elevation myocardial infarction (STEMI) present later than 12 hours after symptom onset. However, data on clinical outcomes in STEMI patients treated with primary percutaneous coronary intervention 12 or more hours after symptom onset are non-existent. We evaluated the association between primary percutaneous coronary intervention performed later than 12 hours after symptom onset and clinical outcomes in a large all-comer contemporary STEMI cohort.Methods: All STEMI patients treated with primary percutaneous coronary intervention in eastern Denmark from November 2009 to November 2016 were included and stratified by timing of the percutaneous coronary intervention. The combined clinical endpoint of all-cause mortality and hospitalisation for heart failure was identified from nationwide Danish registries.Results: We included 6674 patients: 6108 (92%) were treated less than 12 hours and 566 (8%) were treated 12 or more hours after symptom onset. During a median follow-up period of 3.8 (interquartile range 2.3–5.6) years, 30-day, one-year and long-term cumulative rates of the combined endpoint were 11%, 17% and 25% in patients treated 12 or fewer hours and 21%, 29% and 37% in patients treated more than 12 hours (P<0.001 for all) after symptom onset. Late presentation was independently associated with an increased risk of an adverse clinical outcome (hazard ratio 1.42, 95% confidence interval 1.22–1.66; P<0.001).Conclusions: Increasing duration from symptom onset to primary percutaneous coronary intervention was associated with an increased risk of an adverse clinical outcome in patients with STEMI, especially when the delay exceeded 12 hours.

Published
2024
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43. Importance of elevated heart rate in the very early phase of ST-segment elevation myocardial infarction: Results from the DANAMI-3 trial

Author

Nepper-Christensen, Lars, primary, Lønborg, Jacob, additional, Ahtarovski, Kiril A, additional, Høfsten, Dan E, additional, Kyhl, Kasper, additional, Schoos, Mikkel M, additional, Göransson, Christoffer, additional, Laursen, Peter N, additional, Sadjadieh, Golnaz, additional, Ghotbi, Adam Ali, additional, Bertelsen, Litten, additional, Køber, Lars, additional, Helqvist, Steffen, additional, Pedersen, Frants, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Vejlstrup, Niels, additional, Holmvang, Lene, additional, and Engstrøm, Thomas, additional

Published
2018
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44. Assessment of the myocardial area at risk: comparing T2-weighted cardiovascular magnetic resonance imaging with contrast-enhanced cine (CE-SSFP) imaging—a DANAMI3 substudy

Author

Göransson, Christoffer, primary, Ahtarovski, Kiril Aleksov, additional, Kyhl, Kasper, additional, Lønborg, Jacob, additional, Nepper-Christensen, Lars, additional, Bertelsen, Litten, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel Malby, additional, Køber, Lars, additional, Høfsten, Dan, additional, Helqvist, Steffen, additional, Kelbæk, Henning, additional, Engstrøm, Thomas, additional, and Vejlstrup, Niels, additional

Published
2018
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45. MR‐proADM as a Prognostic Marker in Patients With ST‐Segment–Elevation Myocardial Infarction—DANAMI‐3 (a Danish Study of Optimal Acute Treatment of Patients With STEMI) Substudy

Author

Falkentoft, Alexander C., primary, Rørth, Rasmus, additional, Iversen, Kasper, additional, Høfsten, Dan E., additional, Kelbæk, Henning, additional, Holmvang, Lene, additional, Frydland, Martin, additional, Schoos, Mikkel M., additional, Helqvist, Steffen, additional, Axelsson, Anna, additional, Clemmensen, Peter, additional, Jørgensen, Erik, additional, Saunamäki, Kari, additional, Tilsted, Hans‐Henrik, additional, Pedersen, Frants, additional, Torp‐Pedersen, Christian, additional, Kofoed, Klaus F., additional, Goetze, Jens P., additional, Engstrøm, Thomas, additional, and Køber, Lars, additional

Published
2018
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46. Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction

Author

Fakhri, Yama, primary, Sejersten, Maria, additional, Schoos, Mikkel Malby, additional, Hansen, Henrik Steen, additional, Dubois-Rande, Jean-Luc, additional, Hall, Trygve S., additional, Larsen, Alf-Inge, additional, Jensen, Svend Eggert, additional, Engblom, Henrik, additional, Arheden, Hakon, additional, Kastrup, Jens, additional, Atar, Dan, additional, and Clemmensen, Peter, additional

Published
2018
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47. Electrocardiographic scores of severity and acuteness of myocardial ischemia predict myocardial salvage in patients with anterior ST-segment elevation myocardial infarction

Author

Arheden, Hakon, primary, Atar, Dan, additional, Dubois-Rande, Jean-Luc, additional, Fakhri, Yama, additional, Hansen, Henrik Steen, additional, Jensen, Svend Eggert, additional, Kastrup, Jens, additional, Larsen, Alf-Inge, additional, Clemmensen, Peter, additional, Schoos, Mikkel Malby, additional, and Sejersten, Maria, additional

Published
2017
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48. Myocardial Damage in Patients With Deferred Stenting After STEMI

Author

Lønborg, Jacob, primary, Engstrøm, Thomas, additional, Ahtarovski, Kiril Aleksov, additional, Nepper-Christensen, Lars, additional, Helqvist, Steffen, additional, Vejlstrup, Niels, additional, Kyhl, Kasper, additional, Schoos, Mikkel Malby, additional, Ghotbi, Ali, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Holmvang, Lene, additional, Pedersen, Frants, additional, Jørgensen, Erik, additional, Saunamäki, Kari, additional, Clemmensen, Peter, additional, De Backer, Ole, additional, Kløvgaard, Lene, additional, Høfsten, Dan Eik, additional, Køber, Lars, additional, and Kelbæk, Henning, additional

Published
2017
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49. Left Ventricular Hypertrophy Is Associated With Increased Infarct Size and Decreased Myocardial Salvage in Patients With ST‐Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Author

Nepper‐Christensen, Lars, primary, Lønborg, Jacob, additional, Ahtarovski, Kiril Aleksov, additional, Høfsten, Dan Eik, additional, Kyhl, Kasper, additional, Ghotbi, Adam Ali, additional, Schoos, Mikkel Malby, additional, Göransson, Christoffer, additional, Bertelsen, Litten, additional, Køber, Lars, additional, Helqvist, Steffen, additional, Pedersen, Frants, additional, Saünamaki, Kari, additional, Jørgensen, Erik, additional, Kelbæk, Henning, additional, Holmvang, Lene, additional, Vejlstrup, Niels, additional, and Engstrøm, Thomas, additional

Published
2017
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