131 results on '"Schonbrunn, Ernst"'
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2. SARS-CoV-2 Period Seroprevalence and Related Factors, Hillsborough County, Florida, USA, October 2020-March 2021
3. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity
4. Tumor-derived CK1α mutations enhance MDMX inhibition of p53
5. MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling
6. Structural Basis for the Interaction of the Fluorescence Probe 8-anilino-1-naphthalene Sulfonate (ANS) with the Antibiotic Target MurA
7. Abstract 452: Novel autophagy inhibitory strategies to overcome chemotherapy resistance in multiple myeloma
8. Data from Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer
9. Supplementary Figures S1-S7 and Supplementary Methods from Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer
10. Supplementary Tables S1 to S10 from Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer
11. Autoinhibition of MDMX by intramolecular p53 mimicry
12. Abstract PR005: Targeting EP300 and CBP for therapeutic benefit in pediatric solid tumors
13. Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation
14. P-115: Unc-51 Like Kinase 3 protein (ULK3)-mediated autophagy is responsible for multiple myeloma resistance to chemotherapy
15. Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain
16. Abstract 2318: EP300 selectively controls the enhancer landscape of high risk neuroblastoma
17. Molecular basis for the herbicide resistance of Roundup Ready crops
18. Molecular basis of glyphosate resistance − different approaches through protein engineering
19. Discovery of CDK2 allosteric inhibitors for male contraception and anticancer therapy
20. Abstract PR11: EP300 controls the oncogenic enhancer landscape of high-risk neuroblastoma
21. Role of the loop containing residue 115 in the induced-fit mechanism of the bacterial cell wall biosynthetic enzyme MurA
22. New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development
23. Tumor-derived CK1α mutations enhance MDMX inhibition of p53
24. Abstract 359: Dual BET/kinase inhibitors as a novel strategy for the treatment of multiple myeloma
25. Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer
26. Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase–Bromodomain Inhibitor
27. The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA)
28. X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of [NADP.sup.+] binding to ferredoxin NADP reductase from Pseudomonas aeruginosa
29. Differential inhibition of class I and class II 5-enolpyruvylshikimate-3-phosphate synthases by tetrahedral reaction intermediate analogues
30. Biochemical and structural characterization of pseudomonas aeruginosa Bfd and FPR: Ferredoxin [NADP.sup.+] reductase and not ferredoxin is the redox partner of heme oxygenase under iron-starvation conditions
31. Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core
32. Interaction of phosphonate analogues of the tetrahedral reaction intermediate with 5-enolpyruvylshikimate-3-phosphate synthase in atomic detail
33. Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity
34. Intracellular protein degradation of BRD4 by dBET1 reveals conserved in vivo cereblon function in human and mouse T-cells
35. Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks†
36. Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail
37. Back Cover: Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET‐BRET (ChemMedChem 23/2016)
38. Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET‐BRET
39. Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4
40. Abstract 3643: Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy
41. Abstract 3697: Development of a focused non-hydrolyzable phosphopeptide library based on a high affinity SHP2 substrate
42. Abstract 1750: Combined blockade of Aurora A and JAK2 kinase is highly effective at inhibiting malignant transformation
43. Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation
44. Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases
45. Casein Kinase 1α Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding
46. Mti-101 (cyclized HYD1) Binds to CD44 and Induces Necrotic Cell Death in Multiple Myeloma
47. Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors
48. Abstract 3902: Development of Aurora A inhibitors withortho-halophenyl substituted pyrimidines: Unusual potency, SAR and X-ray crystallography studies.
49. Abstract 2942: RKI-1447, a potent ROCK inhibitor with anti-tumor and anti-invasive activities in breast cancer
50. Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors
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