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Dahan da Cunha Nascimento,1,2 Samuel da Cunha Oliveira,1 Denis Cesar Leite Vieira,2,3 Silvana Schwerz Funghetto,4 Alessandro Oliveira Silva,5,6 Renato Valduga,7 Brad Jon Schoenfeld,8 Jonato Prestes1 1Department of Physical Education, Catholic University of Brasilia (UCB), Brasilia, Brazil; 2Department of Physical Education, University Center of the Federal District (UDF), Brasilia, Brazil; 3Department of Physical Education, University of Brasilia (UNB), Brasilia, Brazil; 4Department of Nursing, University of Brasilia (UNB), Brasilia, Brazil; 5University Center of Brasilia (UniCEUB), Brasilia, Brazil; 6Department of Medicine and Physical Education, Integrated Colleges of the Central Plateau Educational Union (FACIPLAC), Brasilia, Brazil; 7Department of Physiotherapy, Secretary of State for Health of the Federal District, Emergency Unit, Ceilandia Regional Hospital, Brasilia, Brazil; 8Department of Health Sciences, CUNY Lehman College, Bronx, NY, USA Objective: The objective of this study was to apply the newly standardized definition for sarcopenia from the Foundation for the National Institutes of Health (FNIH) and the current definition for obesity to 1) determine the prevalence of sarcopenic obesity (SO) in obese elderly women; 2) compare the muscle strength, lean body mass, and markers of inflammation between obese elderly women with SO and nonsarcopenic obesity (NSO), and 3) elucidate the relationship between appendicular lean mass adjusted for body mass index (aLM/BMI) with muscle strength, lean body mass, and obesity indices. Methods: A total of 64 elderly obese women (age: 68.35±6.04 years) underwent body composition analysis by dual-energy X-ray absorptiometry. Participants were classified into two groups according to the definition of SO and NSO. Blood samples were collected for total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, uric acid, urea, interleukin-6 (IL-6), glucose, and creatine kinase (CK) measurements. Results: The SO group presented a significantly greater BMI, fat (%), glucose, a marginal trend toward significance for uric acid, and IL-6 compared to the NSO group. In addition, the SO group displayed lower values for muscle strength and lean body mass. From a correlation standpoint, a higher aLM/BMI was positively associated with lean body mass and muscle strength and negatively associated with a lower BMI and percentage body fat. Conclusion: The definition criteria from FNIH and obesity permit the ability to illustrate the prevalence and identify SO in elderly women with low muscle mass, low muscle strength, and impaired markers of inflammation. Keywords: aging, fat mass, muscles, obesity, sarcopenia, sarcopenic obese

Vânia Silva Macedo Orsano,1,2 Wilson Max Almeida Monteiro de Moraes,2 Nuno Manuel Frade de Sousa,3 Felipe Carmo de Moura,2 Ramires Alsamir Tibana,4 Alessandro de Oliveira Silva,5 Silvana Schwerz Funghetto,6 Brad J Schoenfeld,7 Jonato Prestes2 1Department of Physical Education, Federal University of Piaui (UFPI), Piauí, Brazil; 2Post Graduation Program on Physical Education, Catholic University of Brasilia (UCB), Brasília, Brazil; 3Laboratory of Exercise Physiology, Faculty Estacio of Vitoria, Espirito Santo, Brazil; 4Department of Physical Education, Federal University of Mato Grosso (UFMT), Mato Grosso, Brazil; 5Faculty of Education and Health Sciences, University Center of Brasilia (UniCEUB), Brasília, Brazil; 6Graduation Program in Health Sciences, University of Brasilia (UnB), Brasília, Brazil; 7Department of Health Sciences, CUNY Lehman College, Bronx, NY, USA Objectives: The aim of the present study was to compare the acute effects of traditional resistance training (RT) versus high velocity RT (HVRT) on metabolic, cardiovascular, and psychophysiological responses in elderly hypertensive women. Methods: Fifteen elderly women (mean age ± standard deviation, 67.1±6.9 years) classified as having hypertension stage 1 or 2 were randomly allocated to complete traditional RT or HVRT; 1 week later, subjects allocated to RT completed the HVRT session and vice-versa. Heart rate, blood pressure, affective response, perceived effort, and blood samples analyzing lactate, nitrate, nitrite, oxidative damage (thiobarbituric acid reactive substances [TBARS]), and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid equivalent antioxidant capacity (TEAC) collected before and after training sessions were assessed. Nutritional counseling was provided regarding nutrients that could affect cardiovascular and nitrate/nitrite analysis. Results: Systolic blood pressure was not statistically different (p>0.05) between conditions at the beginning and during 30 minutes after sessions. Diastolic blood pressure, rate pressure product, and heart rate were not statistically different (p>0.05) between conditions at the beginning and during 45 minutes after sessions. Nitric oxide was significantly higher (p

Alessandro de Oliveira Silva,1,2 Maurílio Tiradentes Dutra,3 Wilson Max Almeida Monteiro de Moraes,4 Silvana Schwerz Funghetto,3 Darlan Lopes de Farias,1 Paulo Henrique Fernandes dos Santos,3 Denis Cesar Leite Vieira,5 Dahan da Cunha Nascimento,4,5 Vânia Silva Macedo Orsano,4 Brad J Schoenfeld,6 Jonato Prestes4 1University Center of Brasilia (UniCEUB), Brasília, Brazil; 2Integrated Colleges of the Central Plateau Educational Union (FACIPLAC), Brasília, Brazil; 3University of Brasilia (UnB), Brasília, Brazil; 4Catholic University of Brasilia (UCB), Brasília, Brazil; 5University Center of the Federal District (UDF), Brasília, Brazil; 6Department of Health Sciences, CUNY Lehman College, Bronx, NY, United States Objectives: The purpose of this study was to compare the effects of resistance training (RT) on body composition, muscle strength, and functional capacity in elderly women with and without sarcopenic obesity (SO).Methods: A total of 49 women (aged ≥60 years) were divided in two groups: without SO (non-SO, n=41) and with SO (n=8). Both groups performed a periodized RT program consisting of two weekly sessions for 16 weeks. All measures were assessed at baseline and postintervention, including anthropometry and body composition (dual-energy X-ray absorptiometry), muscle strength (one repetition maximum) for chest press and 45° leg press, and functional capacity (stand up, elbow flexion, timed “up and go”).Results: After the intervention, only the non-SO group presented significant reductions in percentage body fat (-2.2%; P=0.006), waist circumference (-2.7%; P=0.01), waist-to-hip ratio (-2.3; P=0.02), and neck circumference (-1.8%; P=0.03) as compared with baseline. Muscle strength in the chest press and biceps curl increased in non-SO only (12.9% and 11.3%, respectively), while 45° leg press strength increased in non-SO (50.3%) and SO (40.5%) as compared with baseline. Performance in the chair stand up and timed “up and go” improved in non-SO only (21.4% and -8.4%, respectively), whereas elbow flexion performance increased in non-SO (23.8%) and SO (21.4%). Effect sizes for motor tests were of higher magnitude in the non-SO group, and in general, considered “moderate” compared to “trivial” in the SO group.Conclusion: Results suggest that adaptations induced by 16 weeks of RT are attenuated in elderly woman with SO, compromising improvements in adiposity indices and gains in muscle strength and functional capacity. Keywords: aging, obesity, resistance training, sarcopenia

Nelson H Carneiro,1,2 Alex S Ribeiro,1 Matheus A Nascimento,1 Luís A Gobbo,3 Brad J Schoenfeld,4 Abdallah Achour Júnior,1 Sebastião Gobbi,5 Arli R Oliveira,1 Edilson S Cyrino1 1Study and Research Group in Metabolism, Nutrition, and Exercise, Physical Education Department, Londrina State University, Londrina, 2Physical Education Department, Oeste Paulista University, Presidente Prudente, 3Universidade Estadual Paulista, UNESP, Faculdade de Ciência e Tecnologia/Departamento de Educação Física, Presidente Prudente, Brazil; 4Exercise Science Department, The City University of New York Lehman College, Bronx, New York, USA; 5Universidade Estadual Paulista, UNESP, Institudo de Biociências/Departamento de Educação Física, Laboratory of Aging and Physical Activity (LAFE), Rio Carlo, São Paulo, Brazil Objective: The main purpose of the investigation reported here was to analyze the effect of resistance training (RT) performed at different weekly frequencies on flexibility in older women.Participants and methods: Fifty-three older women (≥60 years old) were randomly assigned to perform RT either two (n=28; group “G2x”), or three (n=25; group “G3x”) times per week. The RT program comprised eight exercises in which the participants performed one set of 10–15 repetitions maximum for a period of 12 weeks. Anthropometric, body-composition, and flexibility measurements were made at baseline and post-study. The flexibility measurements were obtained by a fleximeter.Results: A significant group-by-time interaction (P

Background: The chronic effect of static stretching (SS) on muscle hypertrophy is still unclear. This study aimed to examine the chronic effects of SS exercises on skeletal muscle hypertrophy in healthy individuals., Methods: A systematic literature search was conducted in the PubMed, Web of Science, Cochrane Library, and SPORTDiscus databases up to July 2023. Included studies examined chronic effects of SS exercise compared to an active/passive control group or the contralateral leg (i.e., utilizing between- or within-study designs, respectively) and assessed at least one outcome of skeletal muscle hypertrophy in healthy individuals with no age restriction., Results: Twenty-five studies met the inclusion criteria. Overall, findings indicated an unclear effect of chronic SS exercises on skeletal muscle hypertrophy with a trivial point estimate (standardised mean difference [SMD] = 0.118 [95% prediction interval [95% PI] = - 0.233 to 0.469; p = 0.017]) and low heterogeneity (I 2  = 24%). Subgroup analyses revealed that trained individuals (β = 0.424; 95% PI = 0.095 to 0.753) displayed larger effects compared to recreationally trained (β = 0.115; 95% PI = - 0.195 to 0.425) and sedentary individuals (β = - 0.081; 95% PI = - 0.399 to 0.236). Subanalysis suggested the potential for greater skeletal muscle hypertrophy in samples with higher percentages of females (β = 0.003, [95% confidence interval [95% CI] = - 0.000 to 0.005]). However, the practical significance of this finding is questionable. Furthermore, a greater variety of stretching exercises elicited larger increases in muscle hypertrophy (β = 0.069, [95% CI = 0.041 to 0.097]). Longer durations of single stretching exercises (β = 0.006, [95% CI = 0.002 to 0.010]), time under stretching per session (β = 0.006, [95% CI = 0.003 to 0.009]), per week (β = 0.001, [95% CI = 0.000 to 0.001]) and in total (β = 0.008, [95% CI = 0.003 to 0.013]) induced larger muscle hypertrophy. Regarding joint range of motion, there was a clear positive effect with a moderate point estimate (β = 0.698; 95% PI = 0.147 to 1.249; p < 0.001) and moderate heterogeneity (I 2  = 43%). Moreover, findings indicated no significant association between the gains in joint range of motion and the increase in muscle hypertrophy (β = 0.036, [95% CI = - 0.123 to 0.196]; p = 0.638)., Conclusions: This study revealed an overall unclear chronic effect of SS on skeletal muscle hypertrophy, although interpretation across the range of PI suggests a potential modest beneficial effect. Subgroup analysis indicated larger stretching-induced muscle gains in trained individuals, a more varied selection of SS exercises, longer mean duration of single stretching exercise, increased time under SS per session, week, and in total, and possibly in samples with a higher proportion of females. From a practical perspective, it appears that SS exercises may not be highly effective in promoting skeletal muscle hypertrophy unless a higher duration of training is utilized. PROSPERO registration number: CRD42022331762., (© 2024. The Author(s).)

We systematically searched the literature for studies with a randomized design that compared different inter-set rest interval durations for estimates of pre-/post-study changes in lean/muscle mass in healthy adults while controlling all other training variables. Bayesian meta-analyses on non-controlled effect sizes using hierarchical models of all 19 measurements (thigh: 10; arm: 6; whole body: 3) from 9 studies meeting inclusion criteria analyses showed substantial overlap of standardized mean differences across the different inter-set rest periods [binary: short: 0.48 (95%CrI: 0.19-0.81), longer: 0.56 (95%CrI: 0.24-0.86); Four categories: short: 0.47 (95%CrI: 0.19-0.80), intermediate: 0.65 (95%CrI: 0.18-1.1), long: 0.55 (95%CrI: 0.15-0.90), very long: 0.50 (95%CrI: 0.14-0.89)], with substantial heterogeneity in results. Univariate and multivariate pairwise meta-analyses of controlled binary (short vs. longer) effect sizes showed similar results for the arm and thigh with central estimates tending to favor longer rest periods [arm: 0.13 (95%CrI: -0.27 to 0.51); thigh: 0.17 (95%CrI: -0.13 to 0.43)]. In contrast, central estimates closer to zero but marginally favoring shorter rest periods were estimated for the whole body [whole body: -0.08 (95%CrI: -0.45 to 0.29)]. Subanalysis of set end-point data indicated that training to failure or stopping short of failure did not meaningfully influence the interaction between rest interval duration and muscle hypertrophy. In conclusion, results suggest a small hypertrophic benefit to employing inter-set rest interval durations >60 s, perhaps mediated by reductions in volume load. However, our analysis did not detect appreciable differences in hypertrophy when resting >90 s between sets, consistent with evidence that detrimental effects on volume load tend to plateau beyond this time-frame. Systematic Review Registration: OSF, https://doi.org/10.17605/OSF.IO/YWEVC., Competing Interests: BJS formerly served on the scientific advisory board for Tonal Corporation, a manufacturer of fitness equipment. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Singer, Wolf, Generoso, Arias, Delcastillo, Echevarria, Martinez, Androulakis Korakakis, Refalo, Swinton and Schoenfeld.)

Background: Resistance exercise is the most common training modality included within strength and conditioning (S&C) practice. Understanding dose-response relationships between resistance training and a range of outcomes relevant to physical and sporting performance is of primary importance for quality S&C prescription., Objectives: The aim of this meta-analysis was to use contemporary modelling techniques to investigate resistance-only and resistance-dominant training interventions, and explore relationships between training variables (frequency, volume, intensity), participant characteristics (training status, sex), and improvements across a range of outcome domains including maximum strength, power, vertical jump, change of direction, and sprinting performance., Methods: Data were obtained from a database of training studies conducted between 1962 and 2018, which comprised healthy trained or untrained adults engaged in resistance-only or resistance-dominant interventions. Studies were not required to include a control group. Standardized mean difference effect sizes were calculated and interventions categorized according to a range of training variables describing frequency (number of sessions per week), volume (number of sets and repetitions performed), overall intensity (intensity of effort and load, categorised as low, medium or high), and intensity of load (represented as % of one-repetition maximum [1RM] prescribed). Contemporary modelling techniques including Bayesian mixed-effects meta-analytic models were fitted to investigate linear and non-linear dose-responses with models compared based on predictive accuracy., Results: Data from a total of 295 studies comprising 535 groups and 6,710 participants were included with analyses conducted on time points ≤ 26 weeks. The best performing model included: duration from baseline, average number of sets, and the main and interaction effects between outcome domain and intensity of load (% 1RM) expressed non-linearly. Model performance was not improved by the inclusion of participant training status or sex., Conclusions: The current meta-analysis represents the most comprehensive investigation of dose-response relationships across a range of outcome domains commonly targeted within strength and conditioning to date. Results demonstrate the magnitude of improvements is predominantly influenced by training intensity of load and the outcome measured. When considering the effects of intensity as a % 1RM, profiles differ across outcome domains with maximum strength likely to be maximised with the heaviest loads, vertical jump performance likely to be maximised with relatively light loads (~ 30% 1RM), and power likely to be maximised with low to moderate loads (40-70% 1RM)., (© 2024. The Author(s).)

Abstract: González-Cano, H, Martín-Olmedo, JJ, Baz-Valle, E, Contreras, C, Schoenfeld, BJ, García-Ramos, A, Jiménez-Martínez, P, and Alix-Fages, C. Do muscle mass and body fat differ between elite and amateur natural physique athletes on competition day? A preliminary, cross-sectional, anthropometric study. J Strength Cond Res 38(5): 951-956, 2024-Natural physique athletes strive to achieve low body fat levels while promoting muscle mass hypertrophy for competition day. This study aimed to compare the anthropometric characteristics of natural amateur (AMA) and professional (PRO) World Natural Bodybuilding Federation (WNBF) competitors. Eleven male natural physique athletes (6 PRO and 5 AMA; age = 24.8 ± 2.3 years) underwent a comprehensive anthropometric evaluation following the International Society for the Advancement of Kinanthropometry protocol within a 24-hour time frame surrounding the competition. The 5-component fractionation method was used to obtain the body composition profile of the muscle, adipose, bone, skin, and residual tissues. Five physique athletes exceeded the 5.2 cutoff point of muscle-to-bone ratio (MBR) for natural athletes. Professional physique athletes were older than AMA physique athletes (p = 0.05), and they also presented larger thigh girths (p = 0.005) and bone mass (p = 0.019) compared with AMA physique athletes. Although no statistically significant between-group differences were observed in body mass, height, or body fat levels, PRO physique athletes exhibited a higher body mass index (BMI; AMA: 24.45 ± 0.12; PRO: 25.52 ± 1.01; p = 0.048), lean body mass (LBM; AMA: 64.49 ± 2.35; PRO: 69.80 ± 3.78; p = 0.024), fat-free mass (FFM; AMA: 71.23 ± 3.21; PRO: 76.52 ± 4.31; p = 0.05), LBM index (LBMI; AMA: 20.65 ± 0.52; PRO: 21.74 ± 0.85; p = 0.034), and fat-free mass index index (FFMI; AMA: 22.80 ± 0.22; PRO: 23.83 ± 0.90; p = 0.037) compared with AMA physique athletes. These findings highlight the unique characteristics and anthropometric differences between PRO and AMA natural physique athletes on competition day, emphasizing the significance of age, thigh girth, bone mass, BMI, LBM, FFM, and FFMI in distinguishing these 2 groups. Based on our findings, the established boundaries for muscle mass in natural physique athletes, based on FFMI and MBR, warrant reconsideration., (Copyright © 2023 National Strength and Conditioning Association.)

Abstract: Nunes, JP, Blazevich, AJ, Schoenfeld, BJ, Kassiano, W, Costa, BDV, Ribeiro, AS, Nakamura, M, Nosaka, K, and Cyrino, ES. Determining changes in muscle size and architecture after exercise training: One site does not fit all. J Strength Cond Res 38(4): 787-790, 2024-Different methods can be used to assess muscle hypertrophy, but the effects of training on regional changes in muscle size can be detected only using direct muscle measurements such as muscle thickness, cross-sectional area, or volume. Importantly, muscle size increases vary across regions within and between muscles after resistance training programs (i.e., heterogeneous, or nonuniform, muscle hypertrophy). Muscle architectural changes, including fascicle length and pennation angle, after resistance and stretch training programs are also region-specific. In this paper, we show that the literature indicates that a single-site measure of muscle shape does not properly capture the effects achieved after exercise training interventions and that conclusions concerning the magnitude of muscle adaptations can vary substantially depending on the muscle site to be examined. Thus, we propose that measurements of muscle size and architecture should be completed at multiple sites across regions between the agonist muscles within a muscle group and along the length of the muscles to provide an adequate picture of training effects., (Copyright © 2023 National Strength and Conditioning Association.)

Abstract: Fitas, A, Santos, P, Gomes, M, Pezarat-Correia, P, Schoenfeld, BJ, and Mendonca, GV. Prediction of one repetition maximum in free-weight back squat using a mixed approach: the combination of the individual load-velocity profile and generalized equations. J Strength Cond Res 38(2): 228-235, 2024-We aimed to develop a mixed methods approach for 1 repetition maximum (1RM) prediction based on the development of generalized equations and the individual load-velocity profile (LVP), and to explore the validity of such equations for 1RM prediction. Fifty-seven young men volunteered to participate. The submaximal load-velocity relationship was obtained for the free-weight parallel back squat. The estimated load at 0 velocity (LD0) was used as a single predictor, and in combination with the slope of the individual LVP, to develop equations predictive of 1RM. Prediction accuracy was determined through the mean absolute percent error and Bland-Altman plots. LD0 was predictive of 1RM ( p < 0.0001), explaining 70.2% of its variance. Adding the slope of the LVP to the model increased the prediction power of 1RM to 84.4% ( p < 0.0001). The absolute percent error between actual and predicted 1RM was lower for the predictions combining LD0 and slope (6.9 vs. 9.6%). The mean difference between actual and estimated 1RM was nearly zero and showed heteroscedasticity for the LD0 model, but not for the combined model. The limits of agreement error were of 31.9 and 23.5 kg for LD0 and LD0 combined with slope, respectively. In conclusion, the slope of the individual LVP adds predictive value to LD0 in 1RM estimation on a group level and avoids error trends in the estimation of 1RM over the entire spectrum of muscle strength. However, the use of mixed methods does not reach acceptable accuracy for 1RM prediction of the free-weight back squat on an individual basis., (Copyright © 2023 National Strength and Conditioning Association.)

Background: Based on emerging evidence that brief periods of cessation from resistance training (RT) may re-sensitize muscle to anabolic stimuli, we aimed to investigate the effects of a 1-week deload interval at the midpoint of a 9-week RT program on muscular adaptations in resistance-trained individuals., Methods: Thirty-nine young men ( n  = 29) and women ( n  = 10) were randomly assigned to 1 of 2 experimental, parallel groups: An experimental group that abstained from RT for 1 week at the midpoint of a 9-week, high-volume RT program (DELOAD) or a traditional training group that performed the same RT program continuously over the study period (TRAD). The lower body routines were directly supervised by the research staff while upper body training was carried out in an unsupervised fashion. Muscle growth outcomes included assessments of muscle thickness along proximal, mid and distal regions of the middle and lateral quadriceps femoris as well as the mid-region of the triceps surae. Adaptions in lower body isometric and dynamic strength, local muscular endurance of the quadriceps, and lower body muscle power were also assessed., Results: Results indicated no appreciable differences in increases of lower body muscle size, local endurance, and power between groups. Alternatively, TRAD showed greater improvements in both isometric and dynamic lower body strength compared to DELOAD. Additionally, TRAD showed some slight psychological benefits as assessed by the readiness to train questionnaire over DELOAD., Conclusion: In conclusion, our findings suggest that a 1-week deload period at the midpoint of a 9-week RT program appears to negatively influence measures of lower body muscle strength but has no effect on lower body hypertrophy, power or local muscular endurance., Competing Interests: Brad J Schoenfeld serves on the scientific advisory board of Tonal Corporation, a manufacturer of fitness equipment. Michael Israetel is a cofounder of Renaissaince Periodization. The other authors declare that they have no competing interests., (©2024 Coleman et al.)

Regimented resistance training (RT) has been shown to promote increases in muscle size. When engaging in RT, practitioners often emphasize the importance of appropriate exercise technique, especially when trying to maximize training adaptations (e.g., hypertrophy). This narrative review aims to synthesize existing evidence on what constitutes proper RT exercise technique for maximizing muscle hypertrophy, focusing on variables such as exercise-specific kinematics, contraction type, repetition tempo, and range of motion (ROM). We recommend that when trying to maximize hypertrophy, one should employ a ROM that emphasizes training at long muscle lengths while also employing a repetition tempo between 2 and 8 s. More research is needed to determine whether manipulating the duration of either the eccentric or concentric phase further enhances hypertrophy. Guidelines for body positioning and movement patterns are generally based on implied theory from applied anatomy and biomechanics. However, existing research on the impact of manipulating these aspects of exercise technique and their effect on hypertrophy is limited; it is therefore suggested that universal exercise-specific kinematic guidelines are followed and adopted in accordance with the above recommendations. Future research should investigate the impact of stricter versus more lenient exercise technique variations on hypertrophy.

Background: this observational and cross-sectional study aimed to describe training, pharmacological ergogenic aids, dehydration, and nutrition strategies during a peak week in competitive bodybuilders and monitor changes that occurred across this period., Methods: Ten amateur bodybuilders were followed during a peak week phase and one day post-contest. Training, diet, dehydration protocol, anabolic steroid use, and nonsteroidal agents were recorded, prescribed, and supervised by the same coach in charge. Body composition, resting metabolic rate, and circumferences were assessed by the research team., Results: Overall, during the peak week phase, the use of anabolic steroids, diuretics, and other pharmacological aids was high among athletes, and the dose and frequency were similar between competitors. Despite the use of supraphysiological doses of drugs, bodybuilders displayed a statistical reduction of lean mass markers, resting metabolic rate, and fat mass markers, possibly influenced by the performance of high volumes of aerobic exercise combined with dietary energy restriction., Conclusions: The main findings of this study display that the coach in charge of Brazilian bodybuilders applied the same anabolic steroid, diuretic, and other pharmacological protocols for all competitors. Moreover, the protocols employed by bodybuilders did not fully attenuate the loss of lean mass during the peak week period.

Meta-analysis has become commonplace within sport and exercise science for synthesising and summarising empirical studies. However, most research in the field focuses upon mean effects, particularly the effects of interventions to improve outcomes such as fitness or performance. It is thought that individual responses to interventions vary considerably. Hence, interest has increased in exploring precision or personalised exercise approaches. Not only is the mean often affected by interventions, but variation may also be impacted. Exploration of variation in studies such as randomised controlled trials (RCTs) can yield insight into interindividual heterogeneity in response to interventions and help determine generalisability of effects. Yet, larger samples sizes than those used for typical mean effects are required when probing variation. Thus, in a field with small samples such as sport and exercise science, exploration of variation through a meta-analytic framework is appealing. Despite the value of embracing and exploring variation alongside mean effects in sport and exercise science, it is rarely applied to research synthesis through meta-analysis. We introduce and evaluate different effect size calculations along with models for meta-analysis of variation using relatable examples from resistance training RCTs.

Abstract: Varovic, D, Grgic, J, Schoenfeld, BJ, and Vuk, S. Ergogenic effects of sodium bicarbonate on resistance exercise: a randomized, double-blind, placebo-controlled study. J Strength Cond Res 37(8): 1600-1608, 2023-This study explored the effects of sodium bicarbonate ingestion on muscular endurance, power, and velocity in resistance exercise. Nineteen resistance-trained men ingested either 0.3 g·kg -1 of sodium bicarbonate or 0.21 g·kg -1 of placebo (sodium chloride) 180-60 minutes before exercise. The exercise protocol involved performing 3 sets with 70% of 1 repetition maximum to muscular failure in the bench press and biceps curl exercises. Analyzed outcomes included the number of repetitions performed in every set and throughout all 3 sets. In addition, power and velocity of the repetitions were explored by matching the number of repetitions between the sodium bicarbonate and placebo trials. In the bench press exercise, sodium bicarbonate increased the following: (a) the number of repetitions performed in the third set ( g : 0.30; p = 0.046), (b) the total number of repetitions performed throughout all 3 sets ( g : 0.23; p = 0.04), (c) peak power in the second set ( g : 0.19; p = 0.03), and (d) mean power ( g : 0.23; p = 0.03) and mean velocity ( g : 0.30; p = 0.02) in the third set. We did not find a significant difference between the conditions for any of the analyzed outcomes in the biceps curl exercise. Results indicate that sodium bicarbonate ingestion elicits an ergogenic effect on muscular endurance, power, and velocity in the bench press exercise. Given that ergogenic effects were observed only in the second and third sets, these data suggest that sodium bicarbonate acts by attenuating the suppressive effects of acidosis on muscle contractility., (Copyright © 2023 National Strength and Conditioning Association.)

Abstract: Escalante, G, Barakat, C, Tinsley, GM, and Schoenfeld, BJ. Nutrition, training, supplementation, and performance-enhancing drug practices of male and female physique athletes peaking for competition. J Strength Cond Res 37(8): e444-e454, 2023-The purpose of this descriptive investigation was threefold: (a) to assess the nutrition, training, supplement, and performance-enhancement drug practices of male and female physique competitors 30 days before competition; (b) to examine the specific water and macronutrient manipulation performed by competitors during the last 3 days before competition; and (c) to assess physiological responses to precontest preparation including body composition, body fluids, resting heart rate, and blood pressure. Competitors reported performing moderately high volume, moderate to high repetition, split-body resistance training programs performed on most days of the week; the programs included the use of a variety of advanced training methods. A majority of competitors included cardio to expedite fat loss, and most reported performing cardio in a fasted state despite a lack of objective evidentiary support for the practice. Competitors substantially restricted calories and consumed protein in amounts well above research-based guidelines (>3 g·kg -1 ·d -1 ); carbohydrate and lipid intake were highly variable. Water was substantially reduced in the final 3 days before competition. Competitors used a variety of dietary supplements throughout the study period, many of which are not supported by research. Both male and female competitors reported using performance enhancing drugs (∼48 and ∼38%, respectively) including testosterone derivatives, selective androgen receptor modulators, and human growth hormone. More research is warranted to elucidate safer and more effective peak week practices for physique competitors., (Copyright © 2023 National Strength and Conditioning Association.)

Abstract: Rosa, A, Coleman, M, Haun, C, Grgic, J, and Schoenfeld, BJ. Repetition performance, rating of perceived discomfort, and blood lactate responses to different rest interval lengths in single-joint and multijoint lower-body exercise. J Strength Cond Res 37(7): 1350-1357, 2023-The purpose of this study was to examine the effects of different rest interval lengths (RILs) on repetition performance, rating of discomfort, and blood lactate responses during lower-body single-joint and multijoint exercises. This study used a counterbalanced design where each subject performed the Smith machine back squat (BS) and leg extension (LE) using 3 different RIL configurations (1, 2, and 3 minutes) in a randomized fashion. Data collection occurred over the span of 3 separate days. Volunteers were randomly allocated to perform the independent variables (RILs and exercises) in 1 of 12 potential configurations. The initial session was allotted for familiarization with the rating of discomfort scale and 10 repetition maximum testing. The other 2 sessions involved training with the different configurations of RIL length using both the BS and LE. Randomization ensured that the BS was performed first in one of the training sessions and the LE was performed first in the other session. Results indicated that longer RILs had a small positive effect on repetition performance, with longer rest durations allowing for more repetitions compared with shorter durations. The largest difference in repetition performance between RILs was observed between 1 minute and 2-3 minutes rest; there were trivial differences in repetition performance between 2 and 3 minutes rest for both the BS and LE. Blood lactate levels were slightly higher with longer RILs. Overall, BS showed greater increases in blood lactate compared with LE, and these differences were magnified over time. Exercise selection and RIL both influenced rating of discomfort, with LE producing less discomfort than BS and longer RILs reducing perceived discomfort. Our findings suggest that RIL influences the repetition performance, blood lactate, and rating of discomfort responses between single-joint and multijoint exercises., (Copyright © 2023 National Strength and Conditioning Association.)

This study investigated the effects of a 3-week power-oriented resistance training programme performed at moderate altitude on the lower-limb maximal theoretical power and force-velocity (F-V) imbalance of elite judokas. Twenty-two elite male judokas were randomly assigned to either a hypobaric hypoxia or normoxia group. Mechanical outputs from an incremental loaded countermovement jump test were assessed at sea level, before and after training, and 1 week later. Results indicated an increase in the maximal theoretical force and a reduction in the F-V imbalance both at moderate altitude and sea level. Altitude training induced additional benefits when compared to sea level for F-V imbalance (8.4%; CI: 0.3, 17.3%), maximal theoretical power (2.09 W·kg -1 ; CI: 0.13, 4.52 W·kg -1 ) and force (1.32 N·kg -1 ; CI: -0.12, 2.96 N·kg -1 ), jump height (3.24 cm; CI: 2.02, 4.80 cm) and optimal maximal theoretical force (1.61 N·kg -1 ; CI: 0.06, 3.60 N·kg -1 ) and velocity (0.08 m·s -1 ; CI: 0.00, 0.17 m·s -1 ) after the training period. The hypoxia group achieved their best results immediately after the training period, while the normoxia group achieved them one week later. These results suggest that a power-oriented resistance training programme carried out at moderate altitude accelerates and improves the gains in lower-limb muscle power, while minimizing lower-limb imbalances. Therefore, it seems appropriate to compete immediately after the return to sea level and/or use altitude training as a tool to improve muscle power levels of athletes without tapering goals, especially in highly trained power athletes, since their window of adaptation for further power enhancement is smaller. Highlights A 3-week power-oriented resistance training programme improved lower-limb mechanical outputs of elite judokas both at moderate altitude and sea level; training at moderate altitude increases and accelerates these improvements, reducing athletes' imbalances.It may be optimal for judokas to compete immediately after the return to sea level and/or use altitude training as a tool to improve muscle power levels of athletes without tapering goals, especially in highly trained power athletes, since their window of adaptation for further power enhancement is attenuated.Athletes should ensure they possess adequate strength levels before employing a power-oriented training programme to potentiate further improvements in muscle power.

Objectives: Strength training is widely recommended to improve strength, muscle mass and power. However, the feasibility and potential efficacy of strength training using lighter loads near failure on these outcomes in middle and older-aged adults remains unclear., Methods: 23 community-living adults were randomized into two groups: Traditional strength training (ST) (8-12 repetitions) or a lighter load, higher repetitions (LLHR) (20-24 repetitions) group. Participants performed a full-body workout (twice a week) with 8 exercises at a perceived exertion of 7-8 (0-10 scale) for 10 weeks. Post-testing was performed by an assessor blinded to group assignments. An analysis of covariance (ANCOVA) was used to examine between group differences using baseline values as a covariate., Results: The study involved individuals with a mean age of 59 years, of which 61 % were women. The LLHR group demonstrated a high attendance rate of 92 % (9.5 %) and reported leg press exercise RPE of 7.1 (0.53), along with a session feeling scale of 2.0 (1.7). There was a trivial difference in fat free mass (FFM) favoring LLHR vs ST [0.27 kg 95 % CI (-0.87, 1.42)]. The ST group exhibited superior increases in leg press 1 repetition maximum (1RM) strength [-14 kg (-23, -5)], while the LLHR group showed greater strength endurance increases (65 % 1RM) [8 repetitions (2, 14)]. Leg press power [41 W (-42, 124)] and exercise efficacy [-3.8 (-21.2, 13.5)] demonstrated trivial between-group differences., Conclusion: A pragmatic, full-body strength training program with lighter loads taken close to failure appears to be a viable option for promoting muscular adaptations in middle- and older-aged adults. These results are exploratory and require a larger trial for confirmation., Competing Interests: Declaration of competing interest Competing Interests: BJS serves on the scientific advisory board of Tonal Corporation, a manufacturer of fitness equipment., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Purpose: This study evaluated the concurrent training (CT) effect in combination with either progressive energy restriction (PER) or severe energy restriction (SER) on body composition and strength-related variables in resistance-trained women., Methods: Fourteen women (29.5 ± 3.8 years; 23.8 ± 2.8 kg·m -2 ) were randomly assigned to a PER (n = 7) or SER (n = 7) group. Participants performed an 8-week CT program. Pre- and post-intervention measures of fat mass (FM) and fat-free mass (FFM) were assessed by dual-energy X-ray absorptiometry and strength-related variables were assessed through 1-repetition maximum (in the squat and bench press) and countermovement jump., Results: Significant reductions in FM were observed in PER and SER (Δ = - 1.7 ± 0.4 kg; P =  < 0.001; ES = - 0.39 and Δ = - 1.2 ± 0.6 kg; P = 0.002; ES = - 0.20, respectively). After correcting FFM for fat-free adipose tissue (FFAT), no significant differences for this variable were found either in PER (Δ = - 0.3 ± 0.1; P = 0.071; ES = - 0.06) or in SER (Δ = - 0.2 ± 0.1; P = 0.578; ES = - 0.04). There were no significant changes in the strength-related variables. No between-group differences were found in any of the variables., Conclusion: A PER has similar effects to a SER on body composition and strength in resistance-trained women performing a CT program. Given that PER is more flexible and thus may enhance dietary adherence, it might be a better alternative for FM reduction compared to SER., (© 2023. The Author(s).)

This study compared the effects of supervised versus unsupervised resistance training (RT) on measures of muscle strength and hypertrophy in resistance-trained individuals. Thirty-six young men and women were randomly assigned to one of two experimental, parallel groups to complete an 8-week RT programme: One group received direct supervision for their RT sessions (SUP); the other group performed the same RT programme in an unsupervised manner (UNSUP). Programme variables were kept constant between groups. We obtained pre- and post-study assessments of body composition via multi-frequency bioelectrical impedance analysis (MF-BIA), muscle thickness of the upper and lower limbs via ultrasound, 1 repetition maximum (RM) in the back squat and bench press, isometric knee extension strength, and countermovement jump (CMJ) height. Results showed the SUP group generally achieved larger increases in muscle thickness for the triceps brachii, all sites of the rectus femoris, and the proximal region of the vastus lateralis. MF-BIA indicated increases in lean mass favoured SUP. Squat 1RM was greater for SUP; bench press 1RM and isometric knee extension were similar between conditions. CMJ increases modestly favoured UNSUP. In conclusion, our findings suggest that supervised RT promotes greater muscular adaptations and enhances exercise adherence in young, resistance-trained individuals.

The purpose of this study was to compare the effects of electromagnetic resistance alone, as well as in combination with variable resistance or accentuated eccentric methods, with traditional dynamic constant external resistance exercise on myoelectric activity during elbow flexion. The study employed a within-participant randomized, cross-over design whereby 16 young, resistance-trained male and female volunteers performed elbow flexion exercise under each of the following conditions: using a dumbbell (DB); using a commercial electromagnetic resistance device (ELECTRO); variable resistance (VR) using a setting on the device that attempts to match the level of resistance to the human strength curve, and; eccentric overload (EO) using a setting on the device that increases the load by 50% on the eccentric portion of each repetition. Surface electromyography (sEMG) was obtained for the biceps brachii, brachioradialis and anterior deltoid on each of the conditions. Participants performed the conditions at their predetermined 10 repetition maximum. " The order of performance for the conditions was counterbalanced, with trials separated by a 10-min recovery period. The sEMG was synced to a motion capture system to assess sEMG amplitude at elbow joint angles of 30°, 50°, 70°, 90°, 110°, with amplitude normalized to the maximal activation. The anterior deltoid showed the largest differences in amplitude between conditions, where median estimates indicated greater concentric sEMG amplitude (~ 7-10%) with EO, ELECTRO and VR compared with DB. Concentric biceps brachii sEMG amplitude was similar between conditions. In contrast, results indicated a greater eccentric amplitude with DB compared to ELECTRO and VR, but unlikely to exceed a 5% difference. Data indicated a greater concentric and eccentric brachioradialis sEMG amplitude with DB compared to all other conditions, but differences were unlikely to exceed 5%. The electromagnetic device tended to produce greater amplitudes in the anterior deltoid, while DB tended to produce greater amplitudes in the brachioradialis; amplitude for the biceps brachii was relatively similar between conditions. Overall, any observed differences were relatively modest, equating to magnitudes of ~ 5% and not likely greater than 10%. These differences would seem to be of minimal practical significance., (© 2023. The Author(s).)

Resistance training is a method of enhancing strength, gait speed, mobility, and health. However, the external load required to induce these benefits is a contentious issue. A growing body of evidence suggests that when lower load resistance training [i.e., loads < 50% of one-repetition maximum (1RM)] is completed within close proximity to concentric failure, it can serve as an effective alternative to traditional higher load (i.e., loads > 70% of 1RM) training and in many cases can promote similar or even superior physiological adaptations. Such findings are important given that confidence with external loads and access to training facilities and equipment are commonly cited barriers to regular resistance training. Here, we review some of the mechanisms and physiological changes in response to lower load resistance training. We also consider the evidence for applying lower loads for those at risk of cardiovascular and metabolic diseases and those with reduced mobility. Finally, we provide practical recommendations, specifically that to maximize the benefits of lower load resistance training, high levels of effort and training in close proximity to concentric failure are required. Additionally, using lower loads 2-3 times per week with 3-4 sets per exercise, and loads no lower than 30% of 1RM can enhance muscle hypertrophy and strength adaptations. Consequently, implementing lower load resistance training can be a beneficial and viable resistance training method for a wide range of fitness- and health-related goals., (© 2023. The Author(s).)

The present paper aimed to systematically review case studies on physique athletes to evaluate longitudinal changes in measures of body composition, neuromuscular performance, chronic hormonal levels, physiological adaptations, and psychometric outcomes during pre-contest preparation. We included studies that (1) were classified as case studies involving physique athletes during the pre-contest phase of their competitive cycle; (2) involved adults (18+ years of age) as participants; (3) were published in an English-language peer-reviewed journal; (4) had a pre-contest duration of at least 3 months; (5) reported changes across contest preparation relating to measures of body composition (fat mass, lean mass, and bone mineral density), neuromuscular performance (strength and power), chronic hormonal levels (testosterone, estrogen, cortisol, leptin, and ghrelin), physiological adaptations (maximal aerobic capacity, resting energy expenditure, heart rate, blood pressure, menstrual function, and sleep quality), and/or psychometric outcomes (mood states and food desire). Our review ultimately included 11 case studies comprising 15 ostensibly drug-free athletes (male = 8, female = 7) who competed in various physique-oriented divisions including bodybuilding, figure, and bikini. The results indicated marked alterations across the array of analyzed outcomes, sometimes with high inter-individual variability and divergent sex-specific responses. The complexities and implications of these findings are discussed herein.

Cell swelling caused by resistance training is proposed to provide an anabolic stimulus for muscle growth and it is believed that these effects are heightened with the use of low loads. The purpose of this study was to compare the acute effects of two volume-equated resistance training (RT) protocols, low-load (LL) versus high-load (HL), on elbow flexor muscles thickness, arm circumference, and blood lactate concentration in well-trained individuals. Eight resistance-trained males performed the following two RT protocols involving unilateral elbow flexion of the dominant arm: i) LL, four sets with 50% 1 repetition-maximum [1 RM] and ii) HL, ten sets with 85% 1 RM until failure, and equated volume. Pre- and post-session measurements included muscle thickness of the elbow flexors (biceps brachii and brachialis), upper arm circumference, and blood lactate concentration. Significant pre- to post-session increases were found in both protocols for muscle thickness ( F (1, 28) = 11.74, p = 0.0019), and blood lactate ( F (1, 28) = 35.55, p < 0.0001); no statistically significant differences were observed between conditions, however, the magnitude of increases favored LL. Significant between-condition differences favoring LL were observed for total repetitions ( p = 0.007), time under tension ( p = 0.007), and training density ( p = 0.007). These results suggest that LL training promotes superior post-session increases in muscle thickness, indicating that RT protocols with longer times under tension and densities are beneficial when the goal is to promote acute cell swelling.

Abstract: Kassiano, W, Costa, B, Nunes, JP, Ribeiro, AS, Schoenfeld, BJ, and Cyrino, ES. Which ROMs lead to Rome? a systematic review of the effects of range of motion on muscle hypertrophy. J Strength Cond Res 37(5): 1135-1144, 2022-Resistance exercise range of motion (ROM) influences muscular adaptations. However, there are no consistent practical guidelines about the optimal ROM for maximizing muscle hypertrophy. The objective of this article was to systematically review the literature for studies that compared the effects of full ROM (fROM) and partial ROM (pROM) on muscle hypertrophy. PubMed/MEDLINE, Scopus, and Web of Science databases were searched to identify articles from the earliest record up to and including April 2022. We calculated the effect size (ES) scores of the variables of interest. Eleven studies were included in the review. Full ROM and pROM performed in the initial part of the ROM elicited greater muscle hypertrophy of the rectus femoris, vastus lateralis, biceps brachii, and brachialis distal sites (between-groups ES: 0.20-0.90) than pROM performed in the final part of the ROM. fROM elicited greater muscle growth on the gluteus maximus and adductors than pROM in the final part of the ROM (between-groups ES: 0.24-0.25). Initial pROM produced more favorable proximal rectus femoris hypertrophy than fROM (between-groups ES: 0.35-0.38). pROM in the middle part of the ROM elicited greater triceps brachii hypertrophy than fROM (between-group ES: 1.21). In conclusion, evidence suggests that when training at a longer muscle length-through either pROM or fROM-some muscles, such as quadriceps femoris, biceps brachii, and triceps brachii, tend to experience optimal growth. Thus, the use pROM in the initial part of the excursion in combination with fROM training should be considered when prescribing hypertrophy-oriented resistance training programs., (Copyright © 2023 National Strength and Conditioning Association.)

The purpose of this paper was to carry out a systematic review with a meta-analysis of randomized controlled trials that examined the combined effects of resistance training (RT) and creatine supplementation on regional changes in muscle mass, with direct imaging measures of hypertrophy. Moreover, we performed regression analyses to determine the potential influence of covariates. We included trials that had a duration of at least 6 weeks and examined the combined effects of creatine supplementation and RT on site-specific direct measures of hypertrophy (magnetic resonance imaging (MRI), computed tomography (CT), or ultrasound) in healthy adults. A total of 44 outcomes were analyzed across 10 studies that met the inclusion criteria. A univariate analysis of all the standardized outcomes showed a pooled mean estimate of 0.11 (95% Credible Interval (CrI): -0.02 to 0.25), providing evidence for a very small effect favoring creatine supplementation when combined with RT compared to RT and a placebo. Multivariate analyses found similar small benefits for the combination of creatine supplementation and RT on changes in the upper and lower body muscle thickness (0.10-0.16 cm). Analyses of the moderating effects indicated a small superior benefit for creatine supplementation in younger compared to older adults (0.17 (95%CrI: -0.09 to 0.45)). In conclusion, the results suggest that creatine supplementation combined with RT promotes a small increase in the direct measures of skeletal muscle hypertrophy in both the upper and lower body.

Emerging evidence indicates that the use of low-load resistance training in combination with blood flow restriction (LL-BFR) can be an effective method to elicit increases in muscle size, with most research showing similar whole muscle development of the extremities compared to high-load (HL) training. It is conceivable that properties unique to LL-BFR such as greater ischemia, reperfusion, and metabolite accumulation may enhance the stress on type I fibers during training compared to the use of LLs without occlusion. Accordingly, the purpose of this paper was to systematically review the relevant literature on the fiber-type-specific response to LL-BFR and provide insights into future directions for research. A total of 11 studies met inclusion criteria. Results of the review suggest that the magnitude of type I fiber hypertrophy is at least as great, and sometimes greater, than type II hypertrophy when performing LL-BFR. This finding is in contrast to HL training, where the magnitude of type II fiber hypertrophy tends to be substantially greater than that of type I myofibers. However, limited data directly compare training with LL-BFR to nonoccluded LL or HL conditions, thus precluding the ability to draw strong inferences as to whether the absolute magnitude of type I hypertrophy is indeed greater in LL-BFR vs. traditional HL training. Moreover, it remains unclear as to whether combining LL-BFR with traditional HL training may enhance whole muscle hypertrophy via greater increases in type I myofiber cross-sectional area.

Abstract: Spiering, BA, Clark, BC, Schoenfeld, BJ, Foulis, SA, and Pasiakos, SM. Maximizing strength: the stimuli and mediators of strength gains and their application to training and rehabilitation. J Strength Cond Res 37(4): 919-929, 2023-Traditional heavy resistance exercise (RE) training increases maximal strength, a valuable adaptation in many situations. That stated, some populations seek new opportunities for pushing the upper limits of strength gains (e.g., athletes and military personnel). Alternatively, other populations strive to increase or maintain strength but cannot perform heavy RE (e.g., during at-home exercise, during deployment, or after injury or illness). Therefore, the purpose of this narrative review is to (a) identify the known stimuli that trigger gains in strength; (b) identify the known factors that mediate the long-term effectiveness of these stimuli; (c) discuss (and in some cases, speculate on) potential opportunities for maximizing strength gains beyond current limits; and (d) discuss practical applications for increasing or maintaining strength when traditional heavy RE cannot be performed. First, by conceptually deconstructing traditional heavy RE, we identify that strength gains are stimulated through a sequence of events, namely: giving maximal mental effort, leading to maximal neural activation of muscle to produce forceful contractions, involving lifting and lowering movements, training through a full range of motion, and (potentially) inducing muscular metabolic stress. Second, we identify factors that mediate the long-term effectiveness of these RE stimuli, namely: optimizing the dose of RE within a session, beginning each set of RE in a minimally fatigued state, optimizing recovery between training sessions, and (potentially) periodizing the training stimulus over time. Equipped with these insights, we identify potential opportunities for further maximizing strength gains. Finally, we identify opportunities for increasing or maintaining strength when traditional heavy RE cannot be performed., (Copyright © 2022 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.)

Age-related loss of muscle mass, strength, and performance, commonly referred to as sarcopenia, has wide-ranging detrimental effects on human health, the ramifications of which can have serious implications for both morbidity and mortality. Various interventional strategies have been proposed to counteract sarcopenia, with a particular emphasis on those employing a combination of exercise and nutrition. However, the efficacy of these interventions can be confounded by an age-related blunting of the muscle protein synthesis response to a given dose of protein/amino acids, which has been termed "anabolic resistance." While the pathophysiology of sarcopenia is undoubtedly complex, anabolic resistance is implicated in the progression of age-related muscle loss and its underlying complications. Several mechanisms have been proposed as underlying age-related impairments in the anabolic response to protein consumption. These include decreased anabolic molecular signaling activity, reduced insulin-mediated capillary recruitment (thus, reduced amino acid delivery), and increased splanchnic retention of amino acids (thus, reduced availability for muscular uptake). Obesity and sedentarism can exacerbate, or at least facilitate, anabolic resistance, mediated in part by insulin resistance and systemic inflammation. This narrative review addresses the key factors and contextual elements involved in reduction of the acute muscle protein synthesis response associated with aging and its varied consequences. Practical interventions focused on dietary protein manipulation are proposed to prevent the onset of anabolic resistance and mitigate its progression., (© The Author(s) 2022. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

A systematic review and meta-analysis was conducted to determine the effects of resistance training under hypoxic conditions (RTH) on muscle hypertrophy and strength development. Searches of PubMed-Medline, Web of Science, Sport Discus and the Cochrane Library were conducted comparing the effect of RTH versus normoxia (RTN) on muscle hypertrophy (cross sectional area (CSA), lean mass and muscle thickness) and strength development [1-repetition maximum (1RM)]. An overall meta-analysis and subanalyses of training load (low, moderate or high), inter-set rest interval (short, moderate or long) and severity of hypoxia (moderate or high) were conducted to explore the effects on RTH outcomes. Seventeen studies met inclusion criteria. The overall analyses showed similar improvements in CSA (SMD [CIs] = 0.17 [- 0.07; 0.42]) and 1RM (SMD = 0.13 [0.0; 0.27]) between RTH and RTN. Subanalyses indicated a medium effect on CSA for longer inter-set rest intervals and a small effect for moderate hypoxia and moderate loads favoring RTH. Moreover, a moderate effect for longer inter-set rest intervals and a trivial effect for severe hypoxia and moderate loads favoring RTH was found on 1RM. Evidence suggests that RTH employed with moderate loads (60-80% 1RM) and longer inter-set rest intervals (≥ 120 s) enhances muscle hypertrophy and strength compared to normoxia. The use of moderate hypoxia (14.3-16% FiO 2 ) seems to be somewhat beneficial to hypertrophy but not strength. Further research is required with greater standardization of protocols to draw stronger conclusions on the topic., (© 2023. The Author(s).)

Objective: The effects of ROM manipulation on muscle strength and hypertrophy response remain understudied in long-term interventions. Thus, we compared the changes in strength and regional muscle hypertrophy after training in protocols with different ranges of motion (ROM) in the seated dumbbell preacher curl exercise using a within-participant experimental design., Design and Methods: Nineteen young women had one arm randomly assigned to train in the initial ROM (INITIAL ROM : 0°-68°; 0° = extended elbow) while the contralateral arm trained in the final ROM (FINAL ROM : 68°-135°), three times per week over an eight-week study period. Pre- and post-training assessments included one repetition maximum (1RM) testing in the full ROM (0°-135°), and measurement of biceps brachii cross-sectional area (CSA) at 50% and 70% of humerus length. Paired t -tests were used to compare regional CSA changes between groups, the sum of CSA changes at 50% and 70% (CSA summed ), and the strength response between the training protocols., Results: The INITIAL ROM protocol displayed a greater CSA increase than FINAL ROM protocol at 70% of biceps length ( p = 0.001). Alternatively, we observed similar increases between the protocols for CSA at 50% ( p = 0.311) and for CSA summed ( p = 0.111). Moreover, the INITIAL ROM protocol displayed a greater 1RM increase than FINAL ROM ( p < 0.001)., Conclusions: We conclude that training in the initial angles of elbow flexion exercise promotes greater distal hypertrophy of the biceps brachii muscle in untrained young women. Moreover, the INITIAL ROM condition promotes a greater dynamic strength increase when tested at a full ROM compared to the FINAL ROM .

This study's purpose was to compare the effects of different carbohydrate (CHO) intakes on body composition and muscular strength following eight weeks of resistance training (RT) in pre-conditioned men. In addition, we explored the individual responses to different CHO intakes. Twenty-nine young men volunteered to participate in this study. The participants were divided into two groups according to their relative CHO intake: lower (L-CHO; n = 14) and higher (H-CHO; n = 15). Participants performed a RT program four days a week for eight weeks. The lean soft tissue (LST) and fat mass were determined by dual-energy X-ray absorptiometry. Muscular strength was determined by a one-repetition maximum (1RM) test in the bench press, squat, and arm curl exercises. Both groups increased LST ( P < 0.05) with no statistical differences between conditions (L-CHO = +0.8% vs. H-CHO = +3.5%). Neither group demonstrated changes in fat mass. Both groups increased 1RM ( P < 0.05) in the bench press (L-CHO = +3.6% vs. H-CHO = +5.8%) and squat (L-CHO = +7.5% vs. H-CHO = +9.4%); however, only H-CHO significantly increased arm curl 1RM ( P < 0.05) at post-training (L-CHO = +3.0% vs. H-CHO = +6.6%). Responsiveness was greater in H-CHO vs. L-CHO for LST and arm curl 1RM. In conclusion, lower and higher CHO intakes promote similar increase in LST and muscular strength; however, a greater intake may improve the responsiveness to gains in lean mass and arm curl strength in pre-conditioned men.

Introduction: If the aim is to increase maximal strength (MSt) and muscle mass, resistance training (RT) is primarily used to achieve these outcomes. However, research indicates that long-duration stretching sessions of up to 2 h per day can also provide sufficient stimuli to induce muscle growth. In RT literature, sex-related differences in adaptations are widely discussed, however, there is a lack of evidence addressing the sex-related effects on MSt and muscle thickness (MTh) of longer duration stretch training. Therefore, this study aimed to investigate the effects of 6 weeks of daily (1 h) unilateral static stretch training of the plantar flexors using a calf-muscle stretching device. Methods: Fifty-five healthy (m = 28, f = 27), active participants joined the study. MSt and range of motion (ROM) were measured with extended and flexed knee joint, and MTh was investigated in the medial and lateral heads of the gastrocnemius. Results: Statistically significant increases in MSt of 6%-15% ( p < .001-.049, d = 0.45-1.09), ROM of 6%-21% ( p < .001-.037, d = 0.47-1.38) and MTh of 4%-14% ( p < .001-.005, d = 0.46-0.72) from pre-to post-test were observed, considering both sexes and both legs. Furthermore, there was a significant higher increase in MSt, MTh and ROM in male participants. In both groups, participants showed more pronounced adaptations in MSt and ROM with an extended knee joint as well as MTh in the medial head of the gastrocnemius ( p < .001-.047). Results for relative MSt increases showed a similar result ( p < .001-.036, d = 0.48-1.03). Discussion: Results are in accordance with previous studies pointing out significant increases of MSt, MTh and ROM due to long duration static stretch training. Both sexes showed significant increases in listed parameters however, male participants showed superior increases., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Warneke, Zech, Wagner, Konrad, Nakamura, Keiner, Schoenfeld and Behm.)

This study investigated the effects of a relatively high- versus moderate-volume resistance training program on changes in lean mass during caloric restriction. Thirty-eight resistance-trained males were randomized to perform either a high-volume (HVG; 5 sets/exercise) or a moderate-volume (MVG; 3 sets/exercise) resistance training program. Both groups were supervised during lower body training. Participants consumed 30 kcal/kg for 6 weeks after 1 week of weight maintenance (45 kcal/kg), with protein intake fixed at 2.8 g/kg fat-free mass. Muscle thickness of the m. rectus femoris, body composition, contractile properties, stiffness, mood, and sleep status were assessed at pre-, mid-, and post-study. No significant group × time interaction was observed for muscle thickness of the m. rectus femoris at 50% (∆ [post-pre] 0.36 ± 0.93 mm vs. ∆ -0.01 ± 1.59 mm; p = 0.226) and 75% length (∆ -0.32 ± 1.12 mm vs. ∆ 0.08 ± 1.14 mm; p = 0.151), contractility, sleep, and mood in the HVG and MVG, respectively. Body mass (HVG: ∆ -1.69 ± 1.12 kg vs. MVG: ∆ -1.76 ± 1.76 kg) and lean mass (∆ -0.51 ± 2.30 kg vs. ∆ -0.92 ± 1.59 kg) decreased significantly in both groups (p = 0.022), with no between-group difference detected (p = 0.966). High-volume resistance training appears to have neither an advantage nor disadvantage over moderate-volume resistance training in terms of maintaining lean mass or muscle thickness. Given that both groups increased volume load and maintained muscle contractility, sleep quality, and mood, either moderate or higher training volumes conceivably can be employed by resistance-trained individuals to preserve muscle during periods of moderate caloric restriction., (© 2022 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.)

Creatine monohydrate (CM) is an established and effective dietary supplement, but it is not the only form of creatine. We analyzed forms of creatine for sale on Amazon.com" title = "http://Amazon.com">Amazon.com and evaluated if the advertised claims are supported by the available scientific evidence. We also analyzed the cost per gram of the forms of creatine. A total of 175 creatine supplements were included and we reported the total creatine content per serving, form(s) of creatine in products, product claims, and prevalence of products third party certified. The identified products contained 16 forms of creatine other than CM. The prevalence of products containing functional ingredients with CM or forms of creatine was 29.7%, and the prevalence of products containing blends of different forms of creatine was 21.7%. Only 8% of products were third party certified. The products using only CM (n = 91) had a mean price per gram of $0.12 ± 0.08, whereas products using only other forms of creatine (n = 32) had a mean price per gram of $0.26 ± 0.17. Approximately 88% of alternative creatine products in this study are classified as having limited to no evidence to support bioavailability, efficacy, and safety., Competing Interests: The authors declare the following conflict of interests. GE serves as a scientific consultant to Bang and serves/has served as an expert witness on current and past cases related to creatine. GE also serves on the board of directors for Bang. AMG declares that he serves as a scientific advisor for Shifted LLC, a manufacturer of sports supplements. BJS formerly served on the scientific advisory board of Dymatize Nutrition, a manufacturer of sports supplements. DSM is an employee of the UK supplement brand. Supplement Needs and serves as the product formulator for the company; he does not have any formulas or intellectual property with any novel forms of creatine and the company only stocks a single ingredient source of creatine monohydrate. The other authors report they have no conflicts of interest., (© 2022 The Author(s).)

The purpose of this study was to improve our understanding of the relative contributions of biomechanical, anthropometric, and psychological factors in explaining maximal bench press (BP) strength in a heterogeneous, resistance-trained sample. Eighteen college-aged participants reported to the laboratory for three visits. The first visit consisted of psychometric testing. The second visit assessed participants' anthropometrics, additional psychometric outcomes, and bench press one repetition maximum (1RM). Participants performed isometric dynamometry testing for horizontal shoulder adduction and elbow extension at a predicted sticking point joint position. Multiple linear regression was used to examine the relationships between the biomechanical, anthropometric, and psychological variables and BP 1RM. Our primary multiple linear regression accounted for 43% of the variance in BP strength (F(3,14) = 5.34, p = 0.01; R 2 = 0.53; adjusted R 2 = 0.43). The sum of peak isometric net joint moments from the shoulder and elbow had the greatest standardized effect (0.59), followed by lean body mass (0.27) and self-efficacy (0.17). The variance in BP 1RM can be similarly captured (R 2 = 0.48) by a single principal component containing anthropometric, biomechanics, and psychological variables. Pearson correlations with BP strength were generally greater among anthropometric and biomechanical variables as compared to psychological variables. These data suggest that BP strength among a heterogeneous, resistance-trained population is explained by multiple factors and is more strongly associated with physical than psychological variables.

The practice of fasting recently has been purported to have clinical benefits, particularly as an intervention against obesity and its related pathologies. Although a number of different temporal dietary restriction strategies have been employed in practice, they are generally classified under the umbrella term "intermittent fasting" (IF). IF can be stratified into two main categories: (1) intra-weekly fasting (alternate-day fasting/ADF, twice-weekly fasting/TWF) and (2) intra-daily fasting (early time-restricted eating/eTRE and delayed time-restricted eating/dTRE). A growing body of evidence indicates that IF is a viable alternative to daily caloric restriction (DCR), showing effectiveness as a weight loss intervention. This paper narratively reviews the literature on the effects of various commonly used IF strategies on body weight and body composition when compared to traditional DCR approaches, and draws conclusions for their practical application. A specific focus is provided as to the use of IF in combination with regimented exercise programs and the associated effects on fat mass and lean mass.

Time is considered a primary barrier to exercise adherence. Therefore, developing time-efficient resistance training (RT) strategies that optimize muscular adaptations is of primary interest to practitioners. A novel approach to the problem involves combining intensive stretch protocols with RT. Conceivably, integrating stretch into the inter-set period may provide an added stimulus for muscle growth without increasing session duration. Mechanistically, stretch can regulate anabolic signaling via both active and passive force sensors. Emerging evidence indicates that both lengthening contractions against a high load as well as passive stretch can acutely activate anabolic intracellular signaling pathways involved in muscle hypertrophy. Although longitudinal research investigating the effects of stretching between RT sets is limited, some evidence suggests it may in fact enhance hypertrophic adaptations. Accordingly, the purpose of this paper is threefold: (1) to review how the active force of a muscle contraction and the force of a passive stretched are sensed; (2) to present evidence for the effectiveness of RT with inter-set stretch for muscle hypertrophy (3) to provide practical recommendations for application of inter-set stretch in program design as well as directions for future research., Competing Interests: Author BJS serves on the scientific advisory board for Tonal Corporation, a manufacturer of fitness equipment. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Schoenfeld, Wackerhage and De Souza.)

Several studies have explored the effects of capsaicin and capsiate on endurance performance, with conflicting findings. This systematic review aimed to perform a meta-analysis examining the effects of capsaicin and capsiate vs. placebo on endurance performance in humans. Seven databases were searched to find eligible studies. The effects of capsaicin and capsiate on aerobic endurance (e.g., time-trials or time-to-exhaustion tests), muscular endurance (e.g., repetitions performed to muscular failure), and rating of perceived exertion (RPE) were examined in a random-effects meta-analysis. Fourteen studies ( n = 183) were included in the review. Most studies provided capsaicin or capsiate in the dose of 12 mg, 45 min before exercise. In the meta-analysis for aerobic endurance, there was no significant difference between the placebo and capsaicin/capsiate conditions (Cohen's d : 0.04; 95% confidence interval: -0.16, 0.25; p = 0.69). In subgroup meta-analyses, there were no significant differences between the placebo and capsaicin/capsiate conditions when analyzing only studies that used time-trials ( p = 0.20) or time-to-exhaustion tests ( p = 0.80). In the meta-analysis for muscular endurance, a significant ergogenic effect of capsaicin/capsiate was found (Cohen's d : 0.27; 95% confidence interval: 0.10, 0.43; p = 0.002). When analyzing set-specific effects, an ergogenic effect of capsaicin/capsiate was found in set 1, set 2, and set 3 (Cohen's d : 0.21-29). Capsaicin/capsiate ingestion reduced RPE following muscular endurance ( p = 0.03) but not aerobic endurance tests ( p = 0.58). In summary, capsaicin/capsiate supplementation acutely enhances muscular endurance, while the effects on aerobic endurance are less clear.

The present review aims to explore and discuss recent research relating to the lactate response to resistance training and the potential mechanisms by which lactate may contribute to skeletal muscle hypertrophy or help to prevent muscle atrophy. First, we will discuss foundational information pertaining to lactate including metabolism, measurement, shuttling, and potential (although seemingly elusive) mechanisms for hypertrophy. We will then provide a brief analysis of resistance training protocols and the associated lactate response. Lastly, we will discuss potential shortcomings, resistance training considerations, and future research directions regarding lactate's role as a potential anabolic agent for skeletal muscle hypertrophy.

Background: Progressive overload is a principle of resistance training exercise program design that typically relies on increasing load to increase neuromuscular demand to facilitate further adaptations. However, little attention has been given to another way of increasing demand-increasing the number of repetitions., Objective: This study aimed to compare the effects of two resistance training programs: (1) increasing load while keeping repetition range constant vs (2) increasing repetitions while keeping load constant. We aimed to compare the effects of these programs on lower body muscle hypertrophy, muscle strength, and muscle endurance in resistance-trained individuals over an 8-week study period., Methods: Forty-three participants with at least 1 year of consistent lower body resistance training experience were randomly assigned to one of two experimental, parallel groups: A group that aimed to increase load while keeping repetitions constant (LOAD: n = 22; 13 men, nine women) or a group that aimed to increase repetitions while keeping load constant (REPS: n = 21; 14 men, seven women). Subjects performed four sets of four lower body exercises (back squat, leg extension, straight-leg calf raise, and seated calf raise) twice per week. We assessed one repetition maximum (1RM) in the Smith machine squat, muscular endurance in the leg extension, countermovement jump height, and muscle thickness along the quadriceps and calf muscles. Between-group effects were estimated using analyses of covariance, adjusted for pre-intervention scores and sex., Results: Rectus femoris growth modestly favored REPS (adjusted effect estimate (CI 90% ), sum of sites: 2.8 mm [-0.5, 5.8]). Alternatively, dynamic strength increases slightly favored LOAD (2.0 kg [-2.4, 7.8]), with differences of questionable practical significance. No other notable between-group differences were found across outcomes (muscle thicknesses, <1 mm; endurance, <1%; countermovement jump, 0.1 cm; body fat, <1%; leg segmental lean mass, 0.1 kg), with narrow CIs for most outcomes., Conclusion: Both progressions of repetitions and load appear to be viable strategies for enhancing muscular adaptations over an 8-week training cycle, which provides trainers and trainees with another promising approach to programming resistance training., Competing Interests: Brad J Schoenfeld serves on the scientific advisory board of Tonal Corporation, a manufacturer of exercise equipment. Mike Israetel and Jared Feather are employed by Renaissance Periodization. The other authors declare no competing interests., (© 2022 Plotkin et al.)

The aim of this study was to compare the acute effects of performing a lower body resistance training program in one long or two shorter sessions in 1 day on training volume and affective measures. Employing a randomized-crossover design, 23 resistance-trained women (22 ± 2 years, 166 ± 6 cm, and 66.4 ± 7.5 kg) performed two training days consisting of (i) one long (46 min) or (ii) two short sessions (total of 43 min) separated by 3.5-5 h. Each training day was separated by 4-6 days and consisted of three sets to failure for six exercises. Training volume (number of repetitions lifted) were recorded during the sessions. Rating of perceived exertion for effort (RPE), rating of perceived exertion for discomfort (RPD), session displeasure/pleasure (sPDF) and exercise enjoyment (EES) were measured 10 min after each session. Participants also completed a readiness to train questionnaire (7 questions), 24 h after each session, and which training protocol they preferred, 48 h after the last session. The long session led to higher RPE (+1 point, p < 0.001, ES = 1.07), RPD (+1 point, p = 0.043, ES = 0.53) and sPDF ( p = 0.010, ES = 0.59) compared to the short sessions. There was no difference in EES ( p = 0.118, ES = 0.33). The short sessions had 3% higher training volume than the long session ( p = 0.002, ES = 0.42). There were no differences in perceived readiness to train 24 h after the sessions (range: p = 0.166-0.856 and ES = 0.08-0.32). Twenty-two participants preferred the long session, while one preferred the short sessions. In conclusion, performing a longer, lower body, resistance training session led to greater perceptions of effort, discomfort and session pleasure than splitting the same program into two shorter sessions among resistance-trained women. However, two shorter sessions led to a greater training volume., Competing Interests: Author BS serves on the scientific advisory board of Tonal Corporation, a manufacturer of fitness equipment. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Pedersen, Saeterbakken, Fimland, Iversen, Schoenfeld, Stien and Andersen.)