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15. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

Papadopoulos Nikolaos G, Agache Ioana, Bavbek Sevim, Bilo Beatrice M, Braido Fulvio, Cardona Victoria, Custovic Adnan, deMonchy Jan, Demoly Pascal, Eigenmann Philippe, Gayraud Jacques, Grattan Clive, Heffler Enrico, Hellings Peter W, Jutel Marek, Knol Edward, Lötvall Jan, Muraro Antonella, Poulsen Lars K, Roberts Graham, Schmid-Grendelmeier Peter, Skevaki Chrysanthi, Triggiani Massimo, vanRee Ronald, Werfel Thomas, Flood Breda, Palkonen Susanna, Savli Roberta, Allegri Pia, Annesi-Maesano Isabella, Annunziato Francesco, Antolin-Amerigo Dario, Apfelbacher Christian, Blanca Miguel, Bogacka Ewa, Bonadonna Patrizia, Bonini Matteo, Boyman Onur, Brockow Knut, Burney Peter, Buters Jeroen, Butiene Indre, Calderon Moises, Cardell Lars, Caubet Jean-Christoph, Celenk Sevcan, Cichocka-Jarosz Ewa, Cingi Cemal, Couto Mariana, deJong Nicolette, Del Giacco Stefano, Douladiris Nikolaos, Fassio Filippo, Fauquert Jean-Luc, Fernandez Javier, Rivas Montserrat, Ferrer Marta, Flohr Carsten, Gardner James, Genuneit Jon, Gevaert Philippe, Groblewska Anna, Hamelmann Eckard, Hoffmann Hans, Hoffmann-Sommergruber Karin, Hovhannisyan Lilit, Hox Valérie, Jahnsen Frode L, Kalayci Ömer, Kalpaklioglu Ayse, Kleine-Tebbe Jörg, Konstantinou George, Kurowski Marcin, Lau Susanne, Lauener Roger, Lauerma Antti, Logan Kirsty, Magnan Antoine, Makowska Joanna, Makrinioti Heidi, Mangina Paraskevi, Manole Felicia, Mari Adriano, Mazon Angel, Mills Clare, Mingomataj ErvinÇ, Niggemann Bodo, Nilsson Gunnar, Ollert Markus, O'Mahony Liam, O'Neil Serena, Pala Gianni, Papi Alberto, Passalacqua Gianni, Perkin Michael, Pfaar Oliver, Pitsios Constantinos, Quirce Santiago, Raap Ulrike, Raulf-Heimsoth Monika, Rhyner Claudio, Robson-Ansley Paula, Alves Rodrigo, Roje Zeljka, Rondon Carmen, Rudzeviciene Odilija, Ruëff Franziska, Rukhadze Maia, Rumi Gabriele, Sackesen Cansin, Santos Alexandra F, Santucci Annalisa, Scharf Christian, Schmidt-Weber Carsten, Schnyder Benno, Schwarze Jürgen, Senna Gianenrico, Sergejeva Svetlana, Seys Sven, Siracusa Andrea, Skypala Isabel, Sokolowska Milena, Spertini Francois, Spiewak Radoslaw, Sprikkelman Aline, Sturm Gunter, Swoboda Ines, Terreehorst Ingrid, Toskala Elina, Traidl-Hoffmann Claudia, Venter Carina, Vlieg-Boerstra Berber, Whitacker Paul, Worm Margitta, Xepapadaki Paraskevi, and Akdis Cezmi A

Subjects
Allergy, Allergic diseases, Policy, Research needs, Research funding, Europe, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients’ Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients’ organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

Published
2012
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21. Involvement of T cells in drug-induced allergies

Author

Zanni, Martin P., Schnyder, Benno, von Greyerz, Salome, and Pichler, Werner J.

Subjects
T cells -- Research, Drug allergy -- Research, Allergy -- Research, Biological sciences, Chemistry, Pharmaceuticals and cosmetics industries
Abstract

The direct metabolism-independent T-cell stimulation model has been proposed to explain the involvement of T cells in allergies induced by drugs. It theorizes that drug-binding to the major histocompatibility complex (MHC)-peptide complex on the antigen presenting cells (APCs) and T-cell receptor is similar to drug binding in other receptors. The model is based on several findings such as the T cell drug recognition's dependence on the presence of MHC-matched APCs and that T cells recognize the specific antigen by their T-cell receptor.

Published
1998

23. Drug allergy passport and other documentation for patients with drug hypersensitivity:An ENDA/EAACI Drug Allergy Interest Group Position Paper

Author

Brockow, Knut, Aberer, Werner, Atanaskovic-Markovic, M, Bavbek, Sevim, Bircher, Andreas, Bilo, Beatrice M, Blanca, Miguel, Bonadonna, Patrizia, Burbach, G, Calogiuri, G, Caruso, C., Celik, G, Cernadas, J, Chiriac, A M, Demoly, P, Oude Elberink, J N G, Fernandez, J, Gomès, E., Garvey, L H, Gooi, J, Gotua, M, Grosber, M, Kauppi, P, Kvedariene, V, Gómez-Laguna, J., Makowska, J S, Mosbech, H, Nakonechna, A, Papadopolous, N G, Ring, J, Romano, A, Rockmann, H, Sargur, R, Sedlackova, L, Sigurdardottir, S, Schnyder, Benno, Storaas, T, Torres, Mina, Zidarn, M, Terreehorst, Ingrid, Brockow, Knut, Aberer, Werner, Atanaskovic-Markovic, M, Bavbek, Sevim, Bircher, Andreas, Bilo, Beatrice M, Blanca, Miguel, Bonadonna, Patrizia, Burbach, G, Calogiuri, G, Caruso, C., Celik, G, Cernadas, J, Chiriac, A M, Demoly, P, Oude Elberink, J N G, Fernandez, J, Gomès, E., Garvey, L H, Gooi, J, Gotua, M, Grosber, M, Kauppi, P, Kvedariene, V, Gómez-Laguna, J., Makowska, J S, Mosbech, H, Nakonechna, A, Papadopolous, N G, Ring, J, Romano, A, Rockmann, H, Sargur, R, Sedlackova, L, Sigurdardottir, S, Schnyder, Benno, Storaas, T, Torres, Mina, Zidarn, M, and Terreehorst, Ingrid

Abstract

The strongest and best-documented risk factor for drug hypersensitivity (DH) is the history of a previous reaction. Accidental exposures to drugs may lead to severe or even fatal reactions in sensitized patients. Preventable prescription errors are common. They are often due to inadequate medical history or poor risk assessment of recurrence of drug reaction. Proper documentation is essential information for the doctor to make sound therapeutic decision. The European Network on Drug Allergy and Drug Allergy Interest Group of the European Academy of Allergy and Clinical Immunology have formed a task force and developed a drug allergy passport as well as general guidelines of drug allergy documentation. A drug allergy passport, a drug allergy alert card, a certificate, and a discharge letter after medical evaluation are adequate means to document DH in a patient. They are to be handed to the patient who is advised to carry the documentation at all times especially when away from home. A drug allergy passport should at least contain information on the culprit drug(s) including international nonproprietary name, clinical manifestations including severity, diagnostic measures, potential cross-reactivity, alternative drugs to prescribe, and where more detailed information can be obtained from the issuer. It should be given to patients only after full allergy workup. In the future, electronic prescription systems with alert functions will become more common and should include the same information as in paper-based documentation.

Published
2016

26. Avidity determines T-cell reactivity in abacavir hypersensitivity

Author

Adam Jacqueline, Eriksson Klara K, Schnyder Benno, Fontana Stefano, Pichler Werner J, and Yerly Daniel

Subjects
Dose-Response Relationship, Drug, Proteome, Anti-HIV Agents, Antibody Affinity, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, urologic and male genital diseases, Lymphocyte Activation, female genital diseases and pregnancy complications, Dideoxynucleosides, Statistics, Nonparametric, Clone Cells, Drug Hypersensitivity, Kinetics, HLA-B Antigens, Leukocytes, Mononuclear, Humans, Calcium
Abstract

The antiretroviral drug abacavir (abc) elicits severe drug hypersensitivity reactions in HLA-B*5701(+) individuals. To understand the abc-specific activation of CD8(+) T cells, we generated abc-specific T-cell clones (abc-TCCs). Abc reactivity could not be linked to the metabolism and/or processing of the drug, since abc metabolizing enzymes were not expressed in immune cells and inhibition of the proteasome in APCs did not affect TCC reactivity. Ca(2+) influx assays revealed different reactivity patterns of abc-TCCs. While all TCCs reacted to abc presented on HLA-B*5701 molecules, a minority also reacted immediately to abc in solution. Titration experiments showed that the ability to react immediately to abc correlated significantly with the TCR avidity of the T cells. Modifications of soluble abc concentrations revealed that the reactivity patterns of abc-TCCs were not fixed but dynamic. When TCCs with an intermediate TCR avidity were stimulated with increasing abc concentrations, they showed an accelerated activation kinetic. Thus, they reacted immediately to the drug, similar to the reaction of TCCs of high avidity. The observed immediate activation and the noninvolvement of the proteasome suggest that, in contrast to haptens, abc-specific T-cell stimulation does not require the formation of covalent bonds to produce a neo-antigenic determinant.

Published
2011

28. Research needs in allergy: an EAACI position paper, in collaboration with EFA

Author

KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, KUL - University Hospitals Leuven, Spertini, Francois, Sokolowska, Milena, Skypala, Isabel, Spiewak, Radoslaw, Sprikkelman, Aline, Alves, Rodrigo, Sturm, Gunter, Siracusa, Andrea, Seys, Sven, Vlieg-Boerstra, Berber, Venter, Carina, Whitacker, Paul, Swoboda, Ines, Terreehorst, Ingrid, Traidl-Hoffmann, Claudia, Toskala, Elina, Robson-Ansley, Paula, Roje, Zeljka, Schnyder, Benno, Schmidt-Weber, Carsten, Scharf, Christian, Schwarze, Jürgen, Senna, Gianenrico, Akdis, Cezmi A, Sergejeva, Svetlana, Santucci, Annalisa, Santos, Alexandra F, Rudzeviciene, Odilija, Rondon, Carmen, Ruëff, Franziska, Rukhadze, Maia, Sackesen, Cansin, Rumi, Gabriele, Xepapadaki, Paraskevi, Worm, Margitta, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, deMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K, Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, vanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, deJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Ömer, Kalpaklioglu, Ayse, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, ErvinÇ, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, and Rhyner, Claudio

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treat

Published
2012

29. Research needs in allergy:An EAACI position paper, in collaboration with EFA

Author

Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A., Papadopoulos, Nikolaos G., Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M., Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, DeMonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W., Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, VanRee, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, DeJong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L., Kalayci, Ömer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F., Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A.

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and

Published
2012

30. Research needs in allergy:an EAACI position paper, in collaboration with EFA

Author

Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, Akdis, Cezmi A, Papadopoulos, Nikolaos G, Agache, Ioana, Bavbek, Sevim, Bilo, Beatrice M, Braido, Fulvio, Cardona, Victoria, Custovic, Adnan, Demonchy, Jan, Demoly, Pascal, Eigenmann, Philippe, Gayraud, Jacques, Grattan, Clive, Heffler, Enrico, Hellings, Peter W, Jutel, Marek, Knol, Edward, Lötvall, Jan, Muraro, Antonella, Poulsen, Lars K., Roberts, Graham, Schmid-Grendelmeier, Peter, Skevaki, Chrysanthi, Triggiani, Massimo, Vanree, Ronald, Werfel, Thomas, Flood, Breda, Palkonen, Susanna, Savli, Roberta, Allegri, Pia, Annesi-Maesano, Isabella, Annunziato, Francesco, Antolin-Amerigo, Dario, Apfelbacher, Christian, Blanca, Miguel, Bogacka, Ewa, Bonadonna, Patrizia, Bonini, Matteo, Boyman, Onur, Brockow, Knut, Burney, Peter, Buters, Jeroen, Butiene, Indre, Calderon, Moises, Cardell, Lars Olaf, Caubet, Jean-Christoph, Celenk, Sevcan, Cichocka-Jarosz, Ewa, Cingi, Cemal, Couto, Mariana, Dejong, Nicolette, Del Giacco, Stefano, Douladiris, Nikolaos, Fassio, Filippo, Fauquert, Jean-Luc, Fernandez, Javier, Rivas, Montserrat Fernandez, Ferrer, Marta, Flohr, Carsten, Gardner, James, Genuneit, Jon, Gevaert, Philippe, Groblewska, Anna, Hamelmann, Eckard, Hoffmann, Hans Jürgen, Hoffmann-Sommergruber, Karin, Hovhannisyan, Lilit, Hox, Valérie, Jahnsen, Frode L, Kalayci, Omer, Kalpaklioglu, Ayse Füsun, Kleine-Tebbe, Jörg, Konstantinou, George, Kurowski, Marcin, Lau, Susanne, Lauener, Roger, Lauerma, Antti, Logan, Kirsty, Magnan, Antoine, Makowska, Joanna, Makrinioti, Heidi, Mangina, Paraskevi, Manole, Felicia, Mari, Adriano, Mazon, Angel, Mills, Clare, Mingomataj, Ervin C, Niggemann, Bodo, Nilsson, Gunnar, Ollert, Markus, O'Mahony, Liam, O'Neil, Serena, Pala, Gianni, Papi, Alberto, Passalacqua, Gianni, Perkin, Michael, Pfaar, Oliver, Pitsios, Constantinos, Quirce, Santiago, Raap, Ulrike, Raulf-Heimsoth, Monika, Rhyner, Claudio, Robson-Ansley, Paula, Alves, Rodrigo Rodrigues, Roje, Zeljka, Rondon, Carmen, Rudzeviciene, Odilija, Ruëff, Franziska, Rukhadze, Maia, Rumi, Gabriele, Sackesen, Cansin, Santos, Alexandra F, Santucci, Annalisa, Scharf, Christian, Schmidt-Weber, Carsten, Schnyder, Benno, Schwarze, Jürgen, Senna, Gianenrico, Sergejeva, Svetlana, Seys, Sven, Siracusa, Andrea, Skypala, Isabel, Sokolowska, Milena, Spertini, Francois, Spiewak, Radoslaw, Sprikkelman, Aline, Sturm, Gunter, Swoboda, Ines, Terreehorst, Ingrid, Toskala, Elina, Traidl-Hoffmann, Claudia, Venter, Carina, Vlieg-Boerstra, Berber, Whitacker, Paul, Worm, Margitta, Xepapadaki, Paraskevi, and Akdis, Cezmi A

Abstract

In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform

Published
2012

39. Flare-up reactions in severe drug hypersensitivity: infection or ongoing T-cell hyperresponsiveness

Author

Jörg-Walther, Lukas, Schnyder, Benno, Helbling, Arthur, Helsing, Karin, Schüller, Alexandra, Wochner, Annette, and Pichler, Werner

Subjects
610 Medicine & health, 3. Good health
Abstract

"Flare-up" reactions are late manifestations of severe T-cell-mediated drug hypersensitivity reactions. Management is anti-inflammatory treatment and avoiding unnecessary medicines. Symptoms like fever, lymph node swelling, and blood count abnormalities may lead to confusion with bacterial infections. For prompt recognition it is important to keep the differential diagnosis in mind.

40. [Drug hypersensitivity in patients with presumed histamine intolerance and mast cell activation disease].

Author

Schmid-Grendelmeier P and Schnyder B

Subjects
Catechol O-Methyltransferase, Humans, Hypersensitivity, Prospective Studies, Drug Hypersensitivity, Histamine immunology, Mastocytosis immunology
Abstract

Drug hypersensitivity in patients with presumed histamine intolerance and mast cell activation disease Abstract. There is no evidence to suggest that sensitization against drugs occurs more frequently among patients with presumed histamine intolerance compared to patients with normal tolerance to histamine. However, preclinical data suggest interactions between some drugs and histamine catabolism. Nevertheless, the clinical relevance of these findings remains unclear as histamine in humans can be catabolized by different pathways. There are no drugs for which induction or worsening of histamine intolerance has been established clinically. In patients with mastocytosis an increased rate of sensitization and specific allergies to drugs is unlikely. However, pathophysiologic understanding suggests that mast cell activation disease might enhance drug reactions, which are induced by mast cell degranulation. Additionally a possible lower threshold for unspecific mast cell degranulation in patients with mastocytosis could lead to pseudoallergic drug reactions. However an increase in the number of drug substances triggering such reactions is not expected. Nevertheless, there are lists of drug substances which are assumed to cause anaphylactic / anaphylactoid reactions especially in patients with mastocytosis. Conversely, these lists are rarely based on clinical evidence. A recently published prospective trial did not find any relevant increase of acetyl salicylic acid hypersensitivity in patients with mastocytosis. Patients with mastocytosis and a history of drug hypersensitivity should be thoroughly assessed by an allergological workup and advised to avoid triggering and / or cross reactive drug substances. We recommend that these patients avoid drugs which may interfere with the treatment of anaphylaxis like beta blockers, certain antidepressants or Catechol-O-methyltransferase inhibitors because of the increased risk for enhanced hypersensitivity reactions.

Published
2019
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