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Your search keyword '"Schnoeder, Tina M."' showing total 32 results
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32 results on '"Schnoeder, Tina M."'

2. Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia

Author

Tubío-Santamaría, Nuria, Jayavelu, Ashok Kumar, Schnoeder, Tina M., Eifert, Theresa, Hsu, Chen-Jen, Perner, Florian, Zhang, Qirui, Wenge, Daniela V., Hansen, Fynn M., Kirkpatrick, Joanna M., Jyotsana, Nidhi, Lane, Steven W., von Eyss, Björn, Deshpande, Aniruddha J., Kühn, Michael W. M., Schwaller, Juerg, Cammann, Clemens, Seifert, Ulrike, Ebstein, Frédéric, Krüger, Elke, Hochhaus, Andreas, Heuser, Michael, Ori, Alessandro, Mann, Matthias, Armstrong, Scott A., and Heidel, Florian H.

Published
2023
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5. YBX1 mediates translation of oncogenic transcripts to control cell competition in AML

Author

Perner, Florian, Schnoeder, Tina M., Xiong, Yijun, Jayavelu, Ashok Kumar, Mashamba, Nomusa, Santamaria, Nuria Tubio, Huber, Nicolas, Todorova, Kristina, Hatton, Charles, Perner, Birgit, Eifert, Theresa, Murphy, Ciara, Hartmann, Maximilian, Hoell, Jessica I., Schröder, Nicolas, Brandt, Sabine, Hochhaus, Andreas, Mertens, Peter R., Mann, Matthias, Armstrong, Scott A., Mandinova, Anna, and Heidel, Florian H.

Published
2022
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6. PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Author

Schnoeder, Tina M., Schwarzer, Adrian, Jayavelu, Ashok Kumar, Hsu, Chen-Jen, Kirkpatrick, Joanna, Döhner, Konstanze, Perner, Florian, Eifert, Theresa, Huber, Nicolas, Arreba-Tutusaus, Patricia, Dolnik, Anna, Assi, Salam A., Nafria, Monica, Jiang, Lu, Dai, Yu-Ting, Chen, Zhu, Chen, Sai-Juan, Kellaway, Sophie G., Ptasinska, Anetta, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Buschbeck, Marcus, Bierhoff, Holger, Brodt, Steffen, Matziolis, Georg, Fischer, Klaus-Dieter, Hochhaus, Andreas, Chen, Chun-Wei, Heidenreich, Olaf, Mann, Matthias, Lane, Steven W., Bullinger, Lars, Ori, Alessandro, von Eyss, Björn, Bonifer, Constanze, and Heidel, Florian H.

Published
2022
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8. JAK2-V617F promotes venous thrombosis through [[beta].sub.1]/[[beta].sub.2] integrin activation

Author

Edelmann, Barbel, Gupta, Nibedita, Schnoeder, Tina M., Oelschlegel, Anja M., Shahzad, Khurrum, Goldschmidt, Jurgen, Philipsen, Lars, Weinert, Soenke, Ghosh, Aniket, Saalfeld, Felix C., Nimmagadda, Subbaiah Chary, Muller, Peter, Braun- Dullaeus, Rudiger, Mohr, Juliane, Wolleschak, Denise, Kliche, Stefanie, Amthauer, Holger, Heidel, Florian H., Schraven, Burkhart, Isermann, Berend, Muller, Andreas J., and Fischer, Thomas

Subjects
Venous thrombosis -- Genetic aspects -- Development and progression -- Care and treatment, Integrins -- Health aspects, Gene expression -- Health aspects, Health care industry
Abstract

JAK2-V617F-positive chronic myeloproliferative neoplasia (CMN) commonly displays dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes, and leukocytes. However, the mechanism by which the 2 major leukocyte integrin chains, [[beta].sub.1] and [[beta].sub.2], may contribute to CMN pathophysiology remained unclear. [[beta].sub.1] ([[alpha].sub.4][[beta].sub.1]; VLA-4) and [[beta].sub.2] ([[alpha].sub.L][[beta].sub.2]; LFA-1) integrins are essential regulators for attachment of leukocytes to endothelial cells. We here showed enhanced adhesion of granulocytes from mice with JAK2-V617F knockin ([JAK2.sup.+/VF] mice) to vascular cell adhesion molecule 1- (VCAM1-) and intercellular adhesion molecule 1-coated (ICAM1-coated) surfaces. Soluble VCAM1 and ICAM1 ligand binding assays revealed increased affinity of [[beta].sub.1] and [[beta].sub.2] integrins for their respective ligands. For [[beta].sub.1] integrins, this correlated with a structural change from the low- to the high-affinity conformation induced by JAK2-V617F. JAK2- V617F triggered constitutive activation of the integrin inside-out signaling molecule Rap1, resulting in translocation toward the cell membrane. Employing a venous thrombosis model, we demonstrated that neutralizing anti-VLA-4 and anti- [[beta].sub.2] integrin antibodies suppress pathologic thrombosis as observed in [JAK2.sup.+/VF] mice. In addition, aberrant homing of [JAK2.sup.+/VF] leukocytes to the spleen was inhibited by neutralizing anti-[[beta].sub.2] antibodies and by pharmacologic inhibition of Rap1. Thus, our findings identified cross-talk between JAK2-V617F and integrin activation promoting pathologic thrombosis and abnormal trafficking of leukocytes to the spleen., Introduction Chronic myeloproliferative neoplasia (CMN) is a malignant hematopoietic disease characterized by excessive proliferation of one or more myeloid cell lineages as erythrocytes, platelets, or leukocytes. CMN comprises several sub-entities, [...]

Published
2018
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10. Pre-Clinical Investigation of a Novel Small Molecule Inhibitor Targeting YBX1 in AML

Author

Schnoeder, Tina M, primary, Perner, Florian, additional, Jayavelu, Ashok Kumar, additional, Mao, Lianghao, additional, Zhang, Qirui, additional, Hsu, Chen-Jen, additional, Eifert, Theresa, additional, Grunwald, Uwe, additional, Mertens, Peter, additional, Tailor, Dhanir, additional, Taherinasab, Akram, additional, Braun, Theodore P., additional, Malhotra, Sanjay, additional, and Heidel, Florian H., additional

Published
2022
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11. Functional Role of Histone Variant macroH2A1 (H2AFY) in Acute Myeloid Leukemia (AML)

Author

Hsu, Chen-Jen, primary, Schnoeder, Tina M. M, additional, Eifert, Theresa, additional, Zhang, Qirui, additional, Meers, Oliver, additional, Corujo, David, additional, Lassi, Maximilian, additional, Teperino, Raffaele, additional, Dimitrov, Stefan, additional, Bierhoff, Holger, additional, von Eyss, Björn, additional, Perner, Florian, additional, Buschbeck, Marcus, additional, and Heidel, Florian H., additional

Published
2022
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14. YBX1 mediates translation of oncogenic transcripts to control cell competition in AML

Author

Perner, Florian, primary, Schnoeder, Tina M., additional, Xiong, Yijun, additional, Jayavelu, Ashok Kumar, additional, Mashamba, Nomusa, additional, Santamaria, Nuria Tubio, additional, Huber, Nicolas, additional, Todorova, Kristina, additional, Hatton, Charles, additional, Perner, Birgit, additional, Eifert, Theresa, additional, Murphy, Ciara, additional, Hartmann, Maximilian, additional, Hoell, Jessica I., additional, Schröder, Nicolas, additional, Brandt, Sabine, additional, Hochhaus, Andreas, additional, Mertens, Peter R., additional, Mann, Matthias, additional, Armstrong, Scott A., additional, Mandinova, Anna, additional, and Heidel, Florian H., additional

Published
2021
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16. SHP1 regulates a STAT6–ITGB3 axis in FLT3ITD-positive AML cells

Author

Reich, Daniela, primary, Kresinsky, Anne, additional, Müller, Jörg P., additional, Bauer, Reinhard, additional, Kallenbach, Julia, additional, Schnoeder, Tina M., additional, Heidel, Florian H., additional, Fässler, Reinhard, additional, Mann, Matthias, additional, Böhmer, Frank-D., additional, and Jayavelu, Ashok Kumar, additional

Published
2019
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18. Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Author

Schnoeder, Tina M., primary, Schwarzer, Adrian, primary, Perner, Florian, primary, Kirkpatrick, Joanna, primary, Dolnik, Anna, primary, Döhner, Konstanze, primary, Arreba-Tutusaus, Patricia, primary, Assi, Salam A., primary, Bruedigam, Claudia, primary, Kathner, Carolin, primary, Eifert, Theresa, primary, Buschbeck, Marcus, primary, Nafria I Fedi, Monica, primary, Ptasinska, Anetta, primary, Elefanty, Andrew, primary, Ng, Elizabeth, primary, Bierhoff, Holger, primary, Gras, Florian, primary, Matziolis, Georg, primary, Fischer, Klaus-Dieter, primary, Heidenreich, Olaf, primary, Lane, Steven W., primary, Bullinger, Lars, primary, von Eyss, Björn, primary, Ori, Alessandro, primary, Bonifer, Constanze, primary, and Heidel, Florian H., primary

Published
2019
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20. JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation

Author

Edelmann, Bärbel, primary, Gupta, Nibedita, additional, Schnoeder, Tina M., additional, Oelschlegel, Anja M., additional, Shahzad, Khurrum, additional, Goldschmidt, Jürgen, additional, Philipsen, Lars, additional, Weinert, Soenke, additional, Ghosh, Aniket, additional, Saalfeld, Felix C., additional, Nimmagadda, Subbaiah Chary, additional, Müller, Peter, additional, Braun-Dullaeus, Rüdiger, additional, Mohr, Juliane, additional, Wolleschak, Denise, additional, Kliche, Stefanie, additional, Amthauer, Holger, additional, Heidel, Florian H., additional, Schraven, Burkhart, additional, Isermann, Berend, additional, Müller, Andreas J., additional, and Fischer, Thomas, additional

Published
2018
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23. Specificity of JAK-Kinase Inhibition Determines Impact on T-Cell Function

Author

Perner, Florian, primary, Saalfeld, Felix C, additional, Schnoeder, Tina M, additional, Wolleschak, Denise, additional, Fahldieck, Corinna, additional, Ranjan, Satish, additional, Isermann, Berend H, additional, Hebel, Katrin, additional, Brunner-Weinzierl, Monika, additional, Fischer, Thomas, additional, and Heidel, Florian H, additional

Published
2014
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24. Inflammation Induced Expression of Ybx1 Mediates Resistance to JAK-Kinase Inhibitor Therapy in Myeloproliferative Neoplasia

Author

Herzog, Carolin, primary, Polanetzki, Anja, additional, Frey, Stephanie, additional, Schnoeder, Tina M, additional, Wolleschak, Denise, additional, Mashamba, Nomusa, additional, Thangapandi, Veera Raghavan, additional, Jentsch-Ullrich, Kathleen, additional, Kahl, Christoph, additional, Schroeder, Nicolas, additional, Mertens, Peter R, additional, Fischer, Thomas, additional, and Heidel, Florian H, additional

Published
2014
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31. FLT3-Kinase Inhibitors Quizartinib and Midostaurin Do Not Impair T-Cell Reactivity and Activation

Author

Wolleschak, Denise, primary, Mack, Thomas S., additional, Perner, Florian, additional, Schnoeder, Tina M, additional, Wagner, Marie-Christine, additional, Kliche, Stefanie, additional, Schraven, Burkhart, additional, Ranjan, Satish, additional, Isermann, Berend H., additional, Lipka, Daniel B., additional, Fischer, Thomas, additional, and Heidel, Florian H, additional

Published
2012
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32. Distinct Biological and Transcriptional Features Of FLT3-ITD Variants In Vitroand In Vivo

Author

Arreba-Tutusaus, Patricia, Bullinger, Lars, Polanetzki, Anja, Schnoeder, Tina M, Thangapandi, Raghavan V., Döhner, Konstanze, Fischer, Thomas, and Heidel, Florian H

Abstract

Recent publications suggest that mutated FLT3 kinase (FLT3-ITD) is a valid therapeutic target in acute myeloid leukemia (AML). Small molecule FLT3 tyrosine kinase inhibitors (TKIs) of the first and second generation such as midostaurin (PKC412) or quizartinib (AC220) are currently being investigated in advanced clinical trials. Previously, we described that ITD mutations are not always located in the juxtamembrane domain (JMD) of FLT3 but can also be found in the beta1-sheet of tyrosine kinase domain 1 (TKD1) in more than 25% of cases. Moreover, patients harboring ITD mutations in both locations revealed distinct response to chemotherapy: multivariable analyses with regard to achievement of CR, relapse-free survival as well as overall survival revealed consistently similar results, with FLT3-ITD insertion sites in the beta1-sheet of the TKD1 being an unfavorable variable that even outweighed the impact of FLT3-ITD mutant to wildtype allelic ratio.

Published
2013
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