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241 results on '"Schniederjan, Matthew"'

1. Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations

Author

Ross, James L., Puigdelloses-Vallcorba, Montserrat, Piñero, Gonzalo, Soni, Nishant, Thomason, Wes, DeSisto, John, Angione, Angelo, Tsankova, Nadejda M., Castro, Maria G., Schniederjan, Matthew, Wadhwani, Nitin R., Raju, G. Praveen, Morgenstern, Peter, Becher, Oren J., Green, Adam L., Tsankov, Alexander M., and Hambardzumyan, Dolores

Published
2024
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4. Identification and targeting of protein tyrosine kinase 7 (PTK7) as an immunotherapy candidate for neuroblastoma

Author

Lee, Jasmine Y., Jonus, Hunter C., Sadanand, Arhanti, Branella, Gianna M., Maximov, Victor, Suttapitugsakul, Suttipong, Schniederjan, Matthew J., Shim, Jenny, Ho, Andrew, Parwani, Kiran K., Fedanov, Andrew, Pilgrim, Adeiye A., Silva, Jordan A., Schnepp, Robert W., Doering, Christopher B., Wu, Ronghu, Spencer, H. Trent, and Goldsmith, Kelly C.

Published
2023
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5. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis.

Author

Ferris, Sean P, Velazquez Vega, Jose, Aboian, Mariam, Lee, Julieann C, Van Ziffle, Jessica, Onodera, Courtney, Grenert, James P, Saunders, Tara, Chen, Yunn-Yi, Banerjee, Anu, Kline, Cassie N, Gupta, Nalin, Raffel, Corey, Samuel, David, Ruiz-Diaz, Irune, Magaki, Shino, Wilson, Dianne, Neltner, Janna, Al-Hajri, Zahra, Phillips, Joanna J, Pekmezci, Melike, Bollen, Andrew W, Tihan, Tarik, Schniederjan, Matthew, Cha, Soonmee, Perry, Arie, and Solomon, David A

Subjects
Humans, Neoplasms, Neuroepithelial, Glioma, Central Nervous System Neoplasms, Brain Neoplasms, Telomerase, Proto-Oncogene Proteins, Transcription Factors, Repressor Proteins, Genomics, Exons, Adolescent, Child, Child, Preschool, Infant, Female, Male, Cyclin-Dependent Kinase Inhibitor p16, E1A-Associated p300 Protein, Kaplan-Meier Estimate, Biomarkers, Tumor, Oligodendrocyte Transcription Factor 2, BCOR exon 15 internal tandem duplication, HGNET, brain tumor, high-grade neuroepithelial tumor, molecular neuro-oncology, molecular neuropathology, molecular neurooncology, Neurology & Neurosurgery, Clinical Sciences, Neurosciences
Abstract

High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication (HGNET BCOR ex15 ITD) is a recently proposed tumor entity of the central nervous system (CNS) with a distinct methylation profile and characteristic genetic alteration. The complete spectrum of histologic features, accompanying genetic alterations, clinical outcomes, and optimal treatment for this new tumor entity are largely unknown. Here, we performed a comprehensive assessment of 10 new cases of HGNET BCOR ex15 ITD. The tumors mostly occurred in young children and were located in the cerebral or cerebellar hemispheres. On imaging all tumors were large, well-circumscribed, heterogeneous masses with variable enhancement and reduced diffusion. They were histologically characterized by predominantly solid growth, glioma-like fibrillarity, perivascular pseudorosettes, and palisading necrosis, but absence of microvascular proliferation. They demonstrated sparse to absent GFAP expression, no synaptophysin expression, variable OLIG2 and NeuN positivity, and diffuse strong BCOR nuclear positivity. While BCOR exon 15 internal tandem duplication was the solitary pathogenic alteration identified in six cases, four cases contained additional alterations including CDKN2A/B homozygous deletion, TERT amplification or promoter hotspot mutation, and damaging mutations in TP53, BCORL1, EP300, SMARCA2 and STAG2. While the limited clinical follow-up in prior reports had indicated a uniformly dismal prognosis for this tumor entity, this cohort includes multiple long-term survivors. Our study further supports inclusion of HGNET BCOR ex15 ITD as a distinct CNS tumor entity and expands the known clinicopathologic, radiographic, and genetic features.

Published
2020

8. Tumors of the Central Nervous System

Author

Velázquez Vega, José E., Ballester, Leomar Y., Schniederjan, Matthew J., Lin, Fan, Series Editor, Yang, Ximing J., Series Editor, Ding, Yi, editor, and Zhang, Linsheng, editor

Published
2021
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13. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Author

Sturm, Dominik, Orr, Brent A, Toprak, Umut H, Hovestadt, Volker, Jones, David TW, Capper, David, Sill, Martin, Buchhalter, Ivo, Northcott, Paul A, Leis, Irina, Ryzhova, Marina, Koelsche, Christian, Pfaff, Elke, Allen, Sariah J, Balasubramanian, Gnanaprakash, Worst, Barbara C, Pajtler, Kristian W, Brabetz, Sebastian, Johann, Pascal D, Sahm, Felix, Reimand, Jüri, Mackay, Alan, Carvalho, Diana M, Remke, Marc, Phillips, Joanna J, Perry, Arie, Cowdrey, Cynthia, Drissi, Rachid, Fouladi, Maryam, Giangaspero, Felice, Łastowska, Maria, Grajkowska, Wiesława, Scheurlen, Wolfram, Pietsch, Torsten, Hagel, Christian, Gojo, Johannes, Lötsch, Daniela, Berger, Walter, Slavc, Irene, Haberler, Christine, Jouvet, Anne, Holm, Stefan, Hofer, Silvia, Prinz, Marco, Keohane, Catherine, Fried, Iris, Mawrin, Christian, Scheie, David, Mobley, Bret C, Schniederjan, Matthew J, Santi, Mariarita, Buccoliero, Anna M, Dahiya, Sonika, Kramm, Christof M, von Bueren, André O, von Hoff, Katja, Rutkowski, Stefan, Herold-Mende, Christel, Frühwald, Michael C, Milde, Till, Hasselblatt, Martin, Wesseling, Pieter, Rößler, Jochen, Schüller, Ulrich, Ebinger, Martin, Schittenhelm, Jens, Frank, Stephan, Grobholz, Rainer, Vajtai, Istvan, Hans, Volkmar, Schneppenheim, Reinhard, Zitterbart, Karel, Collins, V Peter, Aronica, Eleonora, Varlet, Pascale, Puget, Stephanie, Dufour, Christelle, Grill, Jacques, Figarella-Branger, Dominique, Wolter, Marietta, Schuhmann, Martin U, Shalaby, Tarek, Grotzer, Michael, van Meter, Timothy, Monoranu, Camelia-Maria, Felsberg, Jörg, Reifenberger, Guido, Snuderl, Matija, Forrester, Lynn Ann, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, van Sluis, Peter, Wolf, Stephan, Mikkelsen, Tom, Gajjar, Amar, Aldape, Kenneth, Moore, Andrew S, Taylor, Michael D, and Jones, Chris

Subjects
Humans, Neuroectodermal Tumors, Central Nervous System Neoplasms, Trans-Activators, Proto-Oncogene Proteins, Tumor Suppressor Proteins, Repressor Proteins, Gene Expression Profiling, Signal Transduction, DNA Methylation, Gene Expression Regulation, Neoplastic, Amino Acid Sequence, Molecular Sequence Data, Child, Forkhead Transcription Factors, Neuroblastoma, Cancer, Pediatric, Neurosciences, Brain Disorders, Rare Diseases, Orphan Drug, Brain Cancer, Pediatric Research Initiative, Pediatric Cancer, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

Published
2016

14. DNA Methylation Profiles Are Stable in H3 K27M-Mutant Diffuse Midline Glioma Neurosphere Cell Lines.

Author

Schniederjan, Matthew J., Potnis, Cahil, Vasudevaraja, Varshini, Moser, Catherine D., Watson, Bethany, Snuderl, Matija, MacDonald, Tobey, and Rogers, Beverly B.

Subjects
IN vitro studies, GLIOMAS, RESEARCH funding, CELL proliferation, DESCRIPTIVE statistics, IN vivo studies, DNA methylation, CELL lines, CELL culture, GENE expression profiling, CLUSTER sampling, GENETIC mutation, DATA analysis software
Abstract

Diffuse midline gliomas are among the deadliest human cancers and have had little progress in treatment in the last 50 years. Cell cultures of these tumors have been developed recently, but the degree to which such cultures retain the characteristics of the source tumors is unknown. DNA methylation profiling offers a powerful tool to look at genome-wide epigenetic changes that are biologically meaningful and can help assess the similarity of cultured tumor cells to their in vivo progenitors. Paraffinized diagnostic tissue from three diffuse intrinsic pontine gliomas with H3 K27M mutations was compared with subsequent passages of neurosphere cell cultures from those tumors. Each cell line was passaged 3–4 times and analyzed with DNA methylation arrays and standard algorithms that provided a comparison of diagnostic classification and cluster analysis. All samples tested maintained high classifier scores and clustered within the reference group of H3 K27M-mutant diffuse midline gliomas. There was a gain of 1q in all cell lines, with two cell lines initially manifesting the gain of 1q only during culture. In vitro cell cultures of H3 K27M-mutant gliomas maintain high degrees of similarity in DNA methylation profiles to their source tumor, confirming their fidelity even with some chromosomal changes. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Indoximod-based chemo-immunotherapy for pediatric brain tumors: a first-in-children phase 1 trial

Author

Johnson, Theodore S, primary, MacDonald, Tobey J, additional, Pacholczyk, Rafal, additional, Aguilera, Dolly, additional, Al-Basheer, Ahmad, additional, Bajaj, Manish, additional, Bandopadhayay, Pratiti, additional, Berrong, Zuzana, additional, Bouffet, Eric, additional, Castellino, Robert C, additional, Dorris, Kathleen, additional, Eaton, Bree R, additional, Esiashvili, Natia, additional, Fangusaro, Jason R, additional, Foreman, Nicholas, additional, Fridlyand, Diana, additional, Giller, Cole, additional, Heger, Ian M, additional, Huang, Chenbin, additional, Kadom, Nadja, additional, Kennedy, Eugene P, additional, Manoharan, Neevika, additional, Martin, William, additional, McDonough, Colleen, additional, Parker, Rebecca S, additional, Ramaswamy, Vijay, additional, Ring, Eric, additional, Rojiani, Amyn, additional, Sadek, Ramses F, additional, Satpathy, Sarthak, additional, Schniederjan, Matthew, additional, Smith, Amy, additional, Smith, Christopher, additional, Thomas, Beena E, additional, Vaizer, Rachel, additional, Yeo, Kee Kiat, additional, Bhasin, Manoj K, additional, and Munn, David H, additional

Published
2023
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17. The LIN28B–let‐7–PBK pathway is essential for group 3 medulloblastoma tumor growth and survival

Author

Shahab, Shubin W., primary, Roggeveen, Christianna M., additional, Sun, Jiarong, additional, Kunhiraman, Haritha, additional, McSwain, Leon F., additional, Juraschka, Kyle, additional, Kumar, Sachin A., additional, Saulnier, Olivier, additional, Taylor, Michael D., additional, Schniederjan, Matthew, additional, Schnepp, Robert W., additional, MacDonald, Tobey J, additional, and Kenney, Anna Marie, additional

Published
2023
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19. Synthetic extracellular matrices and astrocytes provide a supportive microenvironment for the cultivation and investigation of primary pediatric gliomas

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Rota, Christopher M, Brown, Alexander T, Addleson, Emily, Ives, Clara, Trumper, Ella, Pelton, Kristine, Teh, Wei Pin, Schniederjan, Matthew J, Castellino, Robert Craig, Buhrlage, Sara, Lauffenburger, Douglas A, Ligon, Keith L, Griffith, Linda G, Segal, Rosalind A, Massachusetts Institute of Technology. Department of Biological Engineering, Rota, Christopher M, Brown, Alexander T, Addleson, Emily, Ives, Clara, Trumper, Ella, Pelton, Kristine, Teh, Wei Pin, Schniederjan, Matthew J, Castellino, Robert Craig, Buhrlage, Sara, Lauffenburger, Douglas A, Ligon, Keith L, Griffith, Linda G, and Segal, Rosalind A

Abstract

Background. Pediatric gliomas comprise a diverse set of brain tumor entities that have substantial long-term ramifications for patient survival and quality of life. However, the study of these tumors is currently limited due to a lack of authentic models. Additionally, many aspects of pediatric brain tumor biology, such as tumor cell invasiveness, have been difficult to study with currently available tools. To address these issues, we developed a synthetic extracellular matrix (sECM)-based culture system to grow and study primary pediatric brain tumor cells. Methods. We developed a brain-like sECM material as a supportive scaffold for the culture of primary, patientderived pediatric glioma cells and established patient-derived cell lines. Primary juvenile brainstem-derived murine astrocytes were used as a feeder layer to support the growth of primary human tumor cells. Results. We found that our culture system facilitated the proliferation of various primary pediatric brain tumors, including low-grade gliomas, and enabled ex vivo testing of investigational therapeutics. Additionally, we found that tuning this sECM material allowed us to assess high-grade pediatric glioma cell invasion and evaluate therapeutic interventions targeting invasive behavior. Conclusion. Our sECM culture platform provides a multipurpose tool for pediatric brain tumor researchers that enables both a wide breadth of biological assays and the cultivation of diverse tumor types.

Published
2023

20. Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis

Author

Lehman, Norman L., Usubalieva, Aisulu, Lin, Tong, Allen, Sariah J., Tran, Quynh T., Mobley, Bret C., McLendon, Roger E., Schniederjan, Matthew J., Georgescu, Maria-Magdalena, Couce, Marta, Dulai, Mohanpal S., Raisanen, Jack M., Al Abbadi, Mousa, Palmer, Cheryl A., Hattab, Eyas M., and Orr, Brent A.

Published
2019
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28. Synthetic extracellular matrices and astrocytes provide a supportive microenvironment for the cultivation and investigation of primary pediatric gliomas

Author

Rota, Christopher M, primary, Brown, Alexander T, additional, Addleson, Emily, additional, Ives, Clara, additional, Trumper, Ella, additional, Pelton, Kristine, additional, Teh, Wei Pin, additional, Schniederjan, Matthew J, additional, Castellino, Robert Craig, additional, Buhrlage, Sara, additional, Lauffenburger, Douglas A, additional, Ligon, Keith L, additional, Griffith, Linda G, additional, and Segal, Rosalind A, additional

Published
2022
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29. Supplement to: Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas.

Author

Brat, Daniel J, Verhaak, Roel GW, Salama, Sofie R., Cooper, Lee, Aldape, Kenneth D, Yung, Alfred W.K, Akbani, Rehan, Barnholtz-Sloan, Jill S., Berger, Mitchel S., Brennan, Cameron, Bristow, Christopher A., Cherniack, Andrew D., Ciriello, Giovanni, Colen, Rivka, Colman, Howard, Flanders, Adam E., Giannini, Caterina, Grifford, Mia, Huse, Jason T., Iavarone, Antonio, Jain, Rajan, Joseph, Isaac, Kim, Jaegil, Kasaian, Katayoon, Laird, Peter W., Mikkelsen, Tom, Miller, Ryan C., Morozova, Olena, Murray, Bradley A., Noushmehr, Houtan, OʼNeill, Brian Patrick, Pachter, Lior, Parsons, Donald W., Poisson, Laila M., Rheinbay, Esther, Robertson, Gordon A., Sougnez, Carrie, Sulman, Erik P., Vandenberg, Scott R., Van Meir, Erwin G., Vitucci, Mark, Deimling, Andreas von, Yoshihara, Kosuke, Zhang, Hailei, Zheng, Siyuan, Crain, Daniel, Lau, Kevin, Mallery, David, Morris, Scott, Paulauskis, Joseph, Penny, Robert, Shelton, Troy, Sherman, Mark, Yena, Peggy, Black, Aaron, Bowen, Jay, Dicostanzo, Katie, Gastier-Foster, Julie, Leraas, Kristen M., Lichtenberg, Tara M., Pierson, Christopher R., Ramirez, Nilsa C., Taylor, Cynthia, Weaver, Stephanie, Wise, Lisa, Zmuda, Erik, Davidsen, Tanja, Demchok, John A., Eley, Greg, Ferguson, Martin L., Hutter, Carolyn M., Mills Shaw, Kenna R., Ozenberger, Bradley A., Sheth, Margi, Sofia, Heidi J., Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zenklusen, Jean Claude, Ayala, Brenda, Baboud, Julien, Chudamani, Sudha, Jensen, Mark A., Liu, Jia, Pihl, Todd, Raman, Rohini, Wan, Yunhu, Wu, Ye, Ally, Adrian, Auman, Todd J., Balasundaram, Miruna, Balu, Saianand, Baylin, Stephen B., Beroukhim, Rameen, Bootwalla, Moiz S., Bowlby, Reanne, Brooks, Denise, Butterfield, Yaron, Carlsen, Rebecca, Carter, Scott, Chin, Lynda, Chu, Andy, Chuah, Eric, Cibulskis, Kristian, Clarke, Amanda, Coetzee, Simon G., Dhalla, Noreen, Fennell, Tim, Fisher, Sheila, Gabriel, Stacey, Getz, Gad, Gibbs, Richard, Grimsby, Jonna L., Guin, Ranabir, Hadjipanayis, Angela, Hayes, Neil D., Hinoue, Toshinori, Hoadley, Katherine, Holt, Robert A., Hoyle, Alan P., Huang, Franklin, Jefferys, Stuart R., Jones, Steven, Jones, Corbin D., Kucherlapati, Raju, Lai, Phillip H., Lander, Eric, Lee, Semin, Lichtenstein, Lee, Ma, Yussanne, Maglinte, Dennis T., Mahadeshwar, Harshad S., Marra, Marco A., Mayo, Michael, Meng, Shaowu, Meyerson, Matthew L., Mieczkowski, Piotr A., Moore, Richard A., Mose, Lisle E., Mungall, Andrew J., Pantazi, Angeliki, Parfenov, Michael, Park, Peter J., Parker, Joel S., Perou, Charles M., Protopopov, Alexei, Ren, Xiaojia, Roach, Jeffrey, Rosenberg, Mara, Sabedot, Thaís S., Sadeghi, Sara, Schein, Jacqueline, Schumacher, Steven E., Seidman, Jonathan G., Seth, Sahil, Shen, Hui, Simons, Janae V., Sipahimalani, Payal, Soloway, Matthew G., Song, Xingzhi, Stewart, Chip, Sun, Huandong, Tabak, Barbara, Tam, Angela, Tan, Donghui, Tang, Jiabin, Thiessen, Nina, Triche, Timothy, Jr., Van Den Berg, David J., Veluvolu, Umadevi, Waring, Scot, Weisenberger, Daniel J., Wilkerson, Matthew D., Wong, Tina, Wu, Junyuan, Xi, Liu, Xu, Andrew W., Yang, Lixing, Zack, Travis I., Zhang, Jianhua, Aksoy, Arman B., Arachchi, Harindra, Benz, Chris, Bernard, Brady, Carlin, Daniel, Cho, Juok, DiCara, Daniel, Frazer, Scott, Fuller, Gregory N., Gao, JianJiong, Gehlenborg, Nils, Haussler, David, Heiman, David I., Iype, Lisa, Jacobsen, Anders, Ju, Zhenlin, Katzman, Sol, Kim, Hoon, Knijnenburg, Theo, Kreisberg, Richard Bailey, Lawrence, Michael S., Lee, William, Leinonen, Kalle, Lin, Pei, Ling, Shiyun, Liu, Wenbin, Liu, Yingchun, Liu, Yuexin, Lu, Yiling, Mills, Gordon, Ng, Sam, Noble, Michael S., Paull, Evan, Radenbaugh, Amie J., Rao, Arvind, Reynolds, Sheila, Saksena, Gordon, Sanborn, Zack, Sander, Chris, Schultz, Nikolaus, Senbabaoglu, Yasin, Shen, Ronglai, Shmulevich, Ilya, Sinha, Rileen, Stuart, Josh, Sumer, Onur S., Sun, Yichao, Tasman, Natalie, Taylor, Barry S., Voet, Doug, Weinhold, Nils, Weinstein, John N., Yang, Da, Zhang, Wei, Zou, Lihua, Abel, Ty, Brat, Daniel J., Cohen, Mark L., Eschbacher, Jenny, Hattab, Eyas M., Raghunathan, Aditya, Schniederjan, Matthew J., Aziz, Dina, Barnett, Gene, Barrett, Wendi, Bigner, Darell D., Boice, Lori, Brewer, Cathy, Calatozzolo, Chiara, Carlotti, Carlos Gilberto, Jr, Chan, Timothy A., Cuppini, Lucia, Curley, Erin, Cuzzubbo, Stefania, Devine, Karen, DiMeco, Francesco, Duell, Rebecca, Elder, Bradley J, Fehrenbach, Ashley, Finocchiaro, Gaetano, Friedman, William, Fulop, Jordonna, Gardner, Johanna, Hermes, Beth, Kendler, Ady, Lehman, Norman L., Lipp, Eric, Liu, Ouida, Mandt, Randy, McGraw, Mary, McLendon, Roger, McPherson, Christopher, Neder, Luciano, Nguyen, Phuong, Noss, Ardene, Nunziata, Raffaele, Ostrom, Quinn T., Palmer, Cheryl, Perin, Alessandro, Pollo, Bianca, Potapov, Alexander, Potapova, Olga, Rathmell, Kimryn W., Rotin, Daniil, Scarpace, Lisa, Schilero, Cathy, Senecal, Kelly, Shimmel, Kristen, Shurkhay, Vsevolod, Sifri, Suzanne, Singh, Rosy, Sloan, Andrew E., Smolenski, Kathy, Staugaitis, Susan M., Steele, Ruth, Thorne, Leigh, Tirapelli, Daniela P.C., Vallurupalli, Mahitha, Wang, Yun, Warnick, Ronald, Williams, Felicia, Wolinsky, Yingli, Zhang, Jianan, Bell, Sue, Campos, Benito, Herold-Mende, Christel, Jungk, Christine, and Unterberg, Andreas

Published
2015

31. Identification and Targeting of Protein Tyrosine Kinase 7 (PTK7) as an Immunotherapy Candidate for Neuroblastoma Cellular Therapy

Author

Lee, Jasmine Y., primary, Jonus, Hunter C., additional, Sadanand, Arhanti, additional, Branella, Gianna M., additional, Maximov, Victor, additional, Suttapitugsakul, Suttipong, additional, Schniederjan, Matthew J., additional, Shim, Jenny, additional, Parwani, Kiran K., additional, Fedanov, Andrew, additional, Pilgrim, Adeiye A., additional, Silva, Jordan A., additional, Doering, Christopher B., additional, Wu, Ronghu, additional, Spencer, H. Trent, additional, and Goldsmith, Kelly C., additional

Published
2022
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35. Intracranial Mass Lesion Caused by Inflammatory Pseudotumor: A Case Report and Discussion

Author

Appert Andrew, Boydston William R, Reisner Andrew, Brahma Barunashish, Myers Hannah, Schniederjan Matthew, Blackwell Laura S, Chern Joshua J, and Prahalad Sampath

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gradenigo Syndrome, Lesion, Skull, medicine.anatomical_structure, Biopsy, medicine, Inflammatory pseudotumor, Radiology, medicine.symptom, business, Intracranial mass
Abstract

Inflammatory pseudo tumors are uncommon lesions that may, on occasion, occupy the intracranial space. Their management is unstandardized. We present a case of skull-based inflammatory pseudotumor in a 14-year-old boy who presented with multiple cranial nerve palsies mimicking Gradenigo syndrome. This illustrative case and a review of the literature is presented to highlight noteworthy features of this rare condition. These include that inflammatory pseudotumor may be multifocal and biopsy of a more accessible, smaller lesion may prove diagnostic.

Published
2021

36. The CD8+ T cell landscape of human brain metastases

Author

Sudmeier, Lisa J., primary, Hoang, Kimberly B., additional, Nduom, Edjah K., additional, Wieland, Andreas, additional, Neill, Stewart G., additional, Schniederjan, Matthew J., additional, Ramalingam, Suresh S., additional, Olson, Jeffrey J., additional, Ahmed, Rafi, additional, and Hudson, William H., additional

Published
2021
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39. Genomic Analysis in the Practice of Surgical Neuropathology: The Emory Experience

Author

Neill, Stewart G., Saxe, Debra F., Rossi, Michael R., Schniederjan, Matthew J., and Brat, Daniel J.

Subjects
Nervous system tumors -- Genetic aspects -- Diagnosis, Gene mutation -- Health aspects, Gene expression -- Health aspects, Health
Abstract

The evaluation of central nervous system tumors increasingly relies on molecular genetic methods to aid in classification, offer prognostic information, and predict response to therapy. Available assays make it possible to assess genetic losses, amplifications, translocations, mutations, or the expression levels of specific gene transcripts or proteins. Current molecular diagnostics frequently use a panel-based approach and whole genome analysis, and generally rely either on DNA sequencing or on hybridization-based methodologies, such as those used in cytogenomic microarrays. In some cases, immunohistochemistry can be used as a surrogate for genetic analysis when the mutation of interest consistently results in overexpression or underexpression of a known protein product. In surgical neuropathology practice, the diagnostic workup of diffuse gliomas, medulloblastomas, low-grade circumscribed gliomas, as well as other diseases, now routinely incorporates the results of genomic studies. Here we summarize our institution's current approach to diagnostic surgical neuropathology, using these contemporary molecular diagnostic applications. doi: 10.5858/arpa.2016-0276-SAI, The practice of surgical pathology is ever dynamic, be it due to the recognition of novel diagnostic entities, adaptation to evolving treatment algorithms, or the utilization of newly developed diagnostic [...]

Published
2017
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40. Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma

Author

Ross, James L, primary, Chen, Zhihong, additional, Herting, Cameron J, additional, Grabovska, Yura, additional, Szulzewsky, Frank, additional, Puigdelloses, Montserrat, additional, Monterroza, Lenore, additional, Switchenko, Jeffrey, additional, Wadhwani, Nitin R, additional, Cimino, Patrick J, additional, Mackay, Alan, additional, Jones, Chris, additional, Read, Renee D, additional, MacDonald, Tobey J, additional, Schniederjan, Matthew, additional, Becher, Oren J, additional, and Hambardzumyan, Dolores, additional

Published
2020
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42. PATH-14. GENETIC SUSCEPTIBILITY AND OUTCOMES OF PEDIATRIC, ADOLESCENT AND YOUNG ADULT IDH-MUTANT ASTROCYTOMAS

Author

Bornhorst, Miriam, primary, Nobre, Liana, additional, Zapotocky, Michal, additional, Barseghyan, Hayk, additional, Goecks, Jeremy, additional, Boue, Daniel, additional, Tabori, Uri, additional, Hawkins, Cynthia, additional, Bouffet, Eric, additional, MacDonald, Tobey, additional, Schniederjan, Matthew, additional, Bronischer, Alberto, additional, Orr, Brent, additional, Solomon, David, additional, Mueller, Sabine, additional, Opocher, Enrico, additional, Vortmeyer, Alexander, additional, Marks, Asher, additional, Koschmann, Carl, additional, Leung, Denise Leung, additional, Mody, Rajen, additional, Hwang, Eugene, additional, Bhattacharya, Surajit, additional, Vilain, Eric, additional, Turner, Joyce, additional, Kilburn, Lindsay, additional, Rood, Brian, additional, Packer, Roger, additional, Nazarian, Javad, additional, and Ho, Cheng-Ying, additional

Published
2020
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