8 results on '"Schnider M"'
Search Results
2. Time of exposure to social defeat stress during childhood and adolescence and redox dysregulation on long-lasting behavioral changes, a translational study
- Author
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Schnider M, Jenni R, Ramain J, Camporesi S, Philippe Golay, Alameda L, Conus P, Do K, and Steullet P
- Subjects
Male ,Social Defeat ,Mice ,N-Methylaspartate ,Animals ,Humans ,Dizocilpine Maleate ,Oxidation-Reduction ,Stress, Psychological/psychology ,Stress, Psychological - Abstract
Traumatic events during childhood/early adolescence can cause long-lasting physiological and behavioral changes with increasing risk for psychiatric conditions including psychosis. Genetic factors and trauma (and their type, degree of repetition, time of occurrence) are believed to influence how traumatic experiences affect an individual. Here, we compared long-lasting behavioral effects of repeated social defeat stress (SD) applied during either peripuberty or late adolescence in adult male WT and Gclm-KO mice, a model of redox dysregulation relevant to schizophrenia. As SD disrupts redox homeostasis and causes oxidative stress, we hypothesized that KO mice would be particularly vulnerable to such stress. We first found that peripubertal and late adolescent SD led to different behavioral outcomes. Peripubertal SD induced anxiety-like behavior in anxiogenic environments, potentiated startle reflex, and increased sensitivity to the NMDA-receptor antagonist, MK-801. In contrast, late adolescent SD led to increased exploration in novel environments. Second, the long-lasting impact of peripubertal but not late adolescent SD differed in KO and WT mice. Peripubertal SD increased anxiety-like behavior in anxiogenic environments and MK-801-sensitivity mostly in KO mice, while it increased startle reflex in WT mice. These suggest that a redox dysregulation during peripuberty interacts with SD to remodel the trajectory of brain maturation, but does not play a significant role during later SD. As peripubertal SD induced persisting anxiety- and fear-related behaviors in male mice, we then investigated anxiety in a cohort of 89 early psychosis male patients for whom we had information about past abuse and clinical assessment during the first year of psychosis. We found that a first exposure to physical/sexual abuse (analogous to SD) before age 12, but not after, was associated with higher anxiety at 6-12 months after psychosis onset. This supports that childhood/peripuberty is a vulnerable period during which physical/sexual abuse in males has wide and long-lasting consequences.
- Published
- 2022
3. Time of exposure to social defeat stress during childhood and adolescence and redox dysregulation on long-lasting behavioral changes, a translational study.
- Author
-
Schnider, M, Jenni, R, Ramain, J, Camporesi, S, Golay, P, Alameda, L, Conus, P, Do, KQ, Steullet, P, Schnider, M, Jenni, R, Ramain, J, Camporesi, S, Golay, P, Alameda, L, Conus, P, Do, KQ, and Steullet, P
- Abstract
Traumatic events during childhood/early adolescence can cause long-lasting physiological and behavioral changes with increasing risk for psychiatric conditions including psychosis. Genetic factors and trauma (and their type, degree of repetition, time of occurrence) are believed to influence how traumatic experiences affect an individual. Here, we compared long-lasting behavioral effects of repeated social defeat stress (SD) applied during either peripuberty or late adolescence in adult male WT and Gclm-KO mice, a model of redox dysregulation relevant to schizophrenia. As SD disrupts redox homeostasis and causes oxidative stress, we hypothesized that KO mice would be particularly vulnerable to such stress. We first found that peripubertal and late adolescent SD led to different behavioral outcomes. Peripubertal SD induced anxiety-like behavior in anxiogenic environments, potentiated startle reflex, and increased sensitivity to the NMDA-receptor antagonist, MK-801. In contrast, late adolescent SD led to increased exploration in novel environments. Second, the long-lasting impact of peripubertal but not late adolescent SD differed in KO and WT mice. Peripubertal SD increased anxiety-like behavior in anxiogenic environments and MK-801-sensitivity mostly in KO mice, while it increased startle reflex in WT mice. These suggest that a redox dysregulation during peripuberty interacts with SD to remodel the trajectory of brain maturation, but does not play a significant role during later SD. As peripubertal SD induced persisting anxiety- and fear-related behaviors in male mice, we then investigated anxiety in a cohort of 89 early psychosis male patients for whom we had information about past abuse and clinical assessment during the first year of psychosis. We found that a first exposure to physical/sexual abuse (analogous to SD) before age 12, but not after, was associated with higher anxiety at 6-12 months after psychosis onset. This supports that childhood/peripuberty is a
- Published
- 2022
4. Superconducting, surface and anomalous electron transport properties of BaNbO 3− x films
- Author
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Gasparov, Vitaly A., Ermolov, S.N., Khassanov, S.S., Strukova, G.K., Gasparov, L.V., Wang, H.S., Li, Qi, Schnider, M., Richter, Wo., Glaser, E., Schmidl, F., Seidel, P., and Brandt, B.L.
- Published
- 2000
- Full Text
- View/download PDF
5. Grosse Erlebniss mit kleinen Hunden
- Author
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Schnider, M.
- Published
- 1951
- Full Text
- View/download PDF
6. Superconducting, surface and anomalous electron transport properties of BaNbO3-x films
- Author
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Gasparov, V. A., Ermolov, S. N., Khassanov, S. S., Strukova, G. K., Gasparov, L. V., Wang, H. S., Li, Q., Schnider, M., Richter, W., and Glaser, E.
- Published
- 2000
- Full Text
- View/download PDF
7. Redesigning the Patient Observer Model to Achieve Increased Efficiency and Staff Engagement on a Surgical Trauma Inpatient Unit.
- Author
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Rachh P, Wilkins G, Capodilupo TA, Kilroy S, Schnider M, and Repper-Delisi J
- Subjects
- Female, Humans, Inpatients, Inservice Training, Male, Patient Safety, Pilot Projects, Process Assessment, Health Care, Risk Assessment, Suicide Prevention, Delirium physiopathology, Efficiency, Organizational, Nursing Assistants organization & administration, Nursing Staff, Hospital organization & administration, Quality of Health Care organization & administration
- Abstract
Background: Provision of safe and efficient observer care to inpatients whose behavior puts them at risk for injury is a clinically challenging and costly endeavor for hospitals. At Massachusetts General Hospital (MGH; Boston), process improvement strategies were deployed to provide staff with an improved clinical model for patient observation, unit-based responsibility for allocating resources, and strategies to maintain a safer environment., Methods: In a surgical trauma unit at MGH, a team of nursing leaders and clinicians created an innovative process to identify, assess, and develop best practices for ensuring patient safety in the hospital environment. Patients with delirium were identified as the most prevalent and concerning patient group, and specific interventions were developed to address their unique needs. From December 2012 through June 2014, the team successfully piloted the best practices (July 16, 2013-September 30, 2013) and implemented them., Results: The baseline outcome metric of patient observer direct-care hours decreased from a median of 208 hours/week (January 1, 2012-July 13, 2013) to a median of 112 hours/week (July 14, 2013-June 28, 2014); a 46% decrease in utilization. Fall rate (falls per 1,000 patient-days) remained unchanged postimplementation, and staff satisfaction with the patient observer model increased from 9% to 72%, while costs associated with providing observer care remained stable., Conclusions: Providing the inpatient unit staff with the knowledge and tools needed to optimally manage patients with at-risk behaviors, including delirium, significantly decreased the number of staff hours spent at the bedside providing observation, did not negatively affect the unit fall rate, and increased staff engagement at no additional expense to the unit.
- Published
- 2016
- Full Text
- View/download PDF
8. Public health interventions: reaching Latino adolescents via short message service and social media.
- Author
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Vyas AN, Landry M, Schnider M, Rojas AM, and Wood SF
- Subjects
- Adolescent, Data Collection, Female, Hispanic or Latino psychology, Humans, Male, Maryland, Risk Reduction Behavior, Sexual Behavior, Public Health, Social Media, Text Messaging
- Abstract
Background: Adolescents are substantial users of short message service (SMS) and social media. The public health community now has more opportunities to reach this population with positive youth development and health messages through these media. Latinos are a growing and youthful population with significant health risks and needs. This population may benefit from SMS and social media health interventions., Objective: To examine (1) SMS and social media utilization and behavior among Latino youth, and (2) how SMS and social media can be effectively used as a component of public health interventions focused on decreasing sexual risk taking among Latino youth., Methods: A mixed-methods approach, using both quantitative survey data and qualitative interview data, was used to provide a robust understanding of SMS and social media use and behavior for public health interventions. We recruited 428 ninth and tenth grade, self-identifying Latino adolescents to participate in a quantitative survey. Additionally, we conducted five key informant interviews with staff and 15 youth., Results: We found that 90.8% (355/391) of respondents had access to a mobile phone either through having their own or through borrowing or sharing one. Of those who had access to a mobile phone, 94.1% (334/355) used SMS, with 41.1% (113/275) sending and receiving more than 100 text messages per day. Of 395 respondents, 384 (97.2%) had at least one social media account, and the mean number of accounts was 3.0 (range 0-8). A total of 75.8% (291/384) of adolescents logged in to their account daily. Of those with a social media account, 89.1% (342/384) had a Facebook account. Youth who took the survey in English were significantly more likely than those who took it in Spanish to have access to a mobile phone (χ(2) (1 )= 5.3; 93.3% vs 86.3%; P = .02); to be high-volume texters (χ(2) (2 )= 16.8; 49.4% vs 25.3%; P < .001); to use the Internet daily (χ(2) (1 )= 5.0; 76.6% vs 66.0%; P = .03); to have a Facebook account (χ(2) (1 )= 9.9; 90.9% vs 79.7%; P = .002); and to have a greater mean number of social media accounts (t(387 )= 7.9; 3.41 vs 2.07; P < .001)., Conclusions: SMS and social media are pervasive among Latino youth. Program staff and youth perceive these as credible and essential methods of communication in the context of public health programs. Public health interventions must continue to innovate and maximize new ways to reach young people to reinforce public health messages and education.
- Published
- 2012
- Full Text
- View/download PDF
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