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3. Hemophagocytic lymphohistiocytosis—how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature

Author

Orth, Hans Martin, Wiemer, Dorothea, Schneitler, Sophie, Schönfeld, Andreas, Holtfreter, Martha Charlotte, Gliga, Smaranda, Fuchs, Andre, Pfäfflin, Frieder, Denkinger, Claudia Maria, Kalbitz, Sven, Fritzsche, Carlos, Hübner, Marc P., Trauth, Janina, Jensen, Björn-Erik Ole, Luedde, Tom, and Feldt, Torsten

Published
2024
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8. Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens

Author

Klemis, Verena, Schmidt, Tina, Schub, David, Mihm, Janine, Marx, Stefanie, Abu-Omar, Amina, Ziegler, Laura, Hielscher, Franziska, Guckelmus, Candida, Urschel, Rebecca, Wagenpfeil, Stefan, Schneitler, Sophie, Becker, Sören L., Gärtner, Barbara C., Sester, Urban, and Sester, Martina

Published
2022
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13. Establishment of a national travel medicine vaccination network to assess reactogenicity of new and rarely used vaccines: a TropNet study.

Author

Köpke, Clara, Rothe, Camilla, Zeder, Andreas, Boecken, Gerhard, Feldt, Torsten, Janke, Christian, Jordan, Sabine, Löbermann, Micha, Müller, Andreas, Orth, Hans-Martin, Prüfer-Krämer, Luise Marie, Schäfer, Johannes, Slesak, Günther, Stich, August, Bélard, Sabine, Thul, Nico, Becker, Sören L, Schneitler, Sophie, and TravVacNet-Group

Subjects
VACCINATION complications, MEDICAL personnel, TRAVEL hygiene, ANTI-vaccination movement, VACCINE effectiveness
Abstract

The article discusses the establishment of a national travel medicine vaccination network in Germany to monitor the reactogenicity of the newly approved Qdenga® vaccine for dengue. Travel medicine specialists were invited to participate in the network, with 99 out of 1238 contacted specialists joining. The network collected data on vaccine tolerability and side effects, with the majority of participants finding the registration process easy and expressing willingness to participate in future activities. The platform aims to provide unbiased data on novel vaccines to facilitate their integration into clinical practice. [Extracted from the article]

Published
2024
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16. Rapid appraisal of liver diseases using transient elastography, abdominal ultrasound, and microbiology in Côte d'Ivoire: A single-center study.

Author

Leibenguth, Marie T., Coulibaly, Jean T., Silué, Kigbafori D., N'Gbesso, Yves K., El Wahed, Ahmed Abd, Utzinger, Jürg, Becker, Sören L., and Schneitler, Sophie

Subjects
LIVER diseases, HEPATIC fibrosis, FATTY liver, DISEASE risk factors, NON-communicable diseases, HEPATITIS B, HEPATITIS C
Abstract

Background: Liver diseases of infectious and non-infectious etiology cause considerable morbidity and mortality, particularly in low- and middle-income countries (LMICs). However, data on the prevalence of liver diseases and underlying risk factors in LMICs are scarce. The objective of this study was to elucidate the occurrence of infectious diseases among individuals with chronic liver damage in a rural setting of Côte d'Ivoire. Methodology: In 2021, we screened 696 individuals from four villages in the southern part of Côte d'Ivoire for hepatic fibrosis and steatosis, employing transient elastography (TE) and controlled attenuation parameter (CAP). We classified CAP ≥248 dB/m as steatosis, TE ≥7.2 kPa as fibrosis, and did subgroup analysis for participants with TE ranging from 7.2 kPa to 9.1 kPa. Clinical and microbiologic characteristics were compared to an age- and sex-matched control group (TE <6.0 kPa; n = 109). Stool samples were subjected to duplicate Kato-Katz thick smears for diagnosis of Schistosoma mansoni. Venous blood samples were examined for hepatitis B and hepatitis C virus. Additionally, an abdominal ultrasound examination was performed. Principal findings: Among 684 individuals with valid TE measurements, TE screening identified hepatic pathologies in 149 participants (17% with fibrosis and 6% with steatosis). 419 participants were included for further analyses, of which 261 had complete microbiological analyses available. The prevalence of S. mansoni, hepatitis B, and hepatitis C were 30%, 14%, and 7%, respectively. Logistic regression analysis revealed higher odds for having TE results between 7.2 kPa and 9.1 kPa in individuals with S. mansoni infection (odds ratio [OR] = 3.02, 95% confidence interval [CI] = 1.58–5.76, P = 0.001), while HCV infection (OR = 5.02, 95% CI = 1.72–14.69, P = 0.003) and steatosis (OR = 4.62, 95% CI = 1.60–13.35, P = 0.005) were found to be risk factors for TE ≥9.2 kPa. Conclusions/Significance: Besides viral hepatitis, S. mansoni also warrants consideration as a pathogen causing liver fibrosis in Côte d'Ivoire. In-depth diagnostic work-up among individuals with abnormal TE findings might be a cost-effective public health strategy. Author summary: At a global scale, chronic liver diseases such as liver fibrosis or cirrhosis are increasing. Causes and risk factors vary from one setting to another. In Europe, alcohol abuse, viral hepatitis, and fatty liver disease are the leading causes. Neglected tropical diseases, especially infections with parasites such as Schistosoma mansoni, are known to cause liver damage in low- and middle-income countries. Precise data on the relevance of infections with S. mansoni compared to other causes of liver fibrosis are scarce. In this study, we aimed to elucidate the infectious diseases etiology of chronic liver diseases in a schistosomiasis-endemic setting of Côte d'Ivoire. We screened residents from four villages in the southern part of Côte d'Ivoire with transient elastography, a non-invasive method that detects liver fibrosis or -cirrhosis by liver stiffness. Participants were tested for schistosomiasis and viral hepatitis, and a questionnaire was used to collect sociodemographic data. We found that liver fibrosis was common (17%), with S. mansoni being the most detected pathogen (30%). Liver diseases have a high morbidity and mortality, resulting in liver cancer or gastrointestinal haemorrhage. Schistosomiasis and hepatitis C, in particular, can be treated effectively today, so a screening program with transient elastography and subsequent treatment could prevent complications of liver disease. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Development of prevalence and incidence of non-tuberculous Mycobacteria in German laboratories from 2016 to 2020

Author

Corbett, Caroline, primary, Finger, Philipp, additional, Heiß-Neumann, Marion, additional, Bohnert, Juergen, additional, Eder, Ines B., additional, Eisele, Melanie, additional, Friesen, Inna, additional, Kaasch, Achim J., additional, Kehrmann, Jan, additional, Lang, Roland, additional, Roedel, Juergen, additional, Roessler, Susann, additional, Schmidt, Annika, additional, Schneitler, Sophie, additional, Schui, Daniela, additional, Schuler, Franziska, additional, Sedlacek, Ludwig, additional, Serr, Annerose, additional, Sitaru, Ana-Gabriela, additional, Steinmann, Joerg, additional, Wagner, Dirk, additional, Wichelhaus, Thomas A., additional, Hofmann-Thiel, Sabine, additional, and Hoffmann, Harald, additional

Published
2023
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20. Hemophagocytic lymphohistiocytosis—how common and how severe is it as a complication of malaria? Retrospective case series and review of the literature

Author

Orth, Hans Martin, primary, Wiemer, Dorothea, additional, Schneitler, Sophie, additional, Schönfeld, Andreas, additional, Holtfreter, Martha Charlotte, additional, Gliga, Smaranda, additional, Fuchs, Andre, additional, Pfäfflin, Frieder, additional, Denkinger, Claudia Maria, additional, Kalbitz, Sven, additional, Fritzsche, Carlos, additional, Hübner, Marc P., additional, Trauth, Janina, additional, Jensen, Björn-Erik Ole, additional, Luedde, Tom, additional, and Feldt, Torsten, additional

Published
2023
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22. Occurrence, resistance patterns, and management of carbapenemase-producing bacteria in war-wounded refugees from Ukraine

Author

Berger, Fabian K., primary, Schmartz, Georges P., additional, Fritz, Tobias, additional, Veith, Nils, additional, Alhussein, Farah, additional, Roth, Sophie, additional, Schneitler, Sophie, additional, Gilcher, Thomas, additional, Gärtner, Barbara C., additional, Pirpilashvili, Vakhtang, additional, Pohlemann, Tim, additional, Keller, Andreas, additional, Rehner, Jacqueline, additional, and Becker, Sören L., additional

Published
2023
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24. SARS-CoV-2 specific cellular and humoral immunity after bivalent BA.4/5 COVID-19 vaccination in previously infected and non-infected individuals

Author

Urschel, Rebecca, primary, Bronder, Saskia, additional, Klemis, Verena, additional, Marx, Stefanie, additional, Hielscher, Franziska, additional, Abu-Omar, Amina, additional, Guckelmus, Candida, additional, Schneitler, Sophie, additional, Baum, Christina, additional, Becker, Sören L., additional, Gärtner, Barbara C., additional, Sester, Urban, additional, Widera, Marek, additional, Schmidt, Tina, additional, and Sester, Martina, additional

Published
2023
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26. SARS-CoV-2 specific cellular and humoral immunity after bivalent BA.4/5 COVID-19 vaccination in previously infected and non-infected individuals

Author

Urschel, Rebecca, Bronder, Saskia, Klemis, Verena, Marx, Stefanie, Hielscher, Franziska, Abu-Omar, Amina, Guckelmus, Candida, Schneitler, Sophie Charlotte, Baum, Christina, Becker, Sören Leif, Gärtner, Barbara, Sester, Urban, Widera, Marek, Schmidt, Tina, Sester, Martina, Urschel, Rebecca, Bronder, Saskia, Klemis, Verena, Marx, Stefanie, Hielscher, Franziska, Abu-Omar, Amina, Guckelmus, Candida, Schneitler, Sophie Charlotte, Baum, Christina, Becker, Sören Leif, Gärtner, Barbara, Sester, Urban, Widera, Marek, Schmidt, Tina, and Sester, Martina

Abstract

Knowledge is limited as to how prior SARS-CoV-2 infection influences cellular and humoral immunity after booster-vaccination with bivalent BA.4/5-adapted mRNA-vaccines, and whether vaccine-induced immunity correlates with subsequent infection. In this observational study, individuals with prior infection (n=64) showed higher vaccine-induced anti-spike IgG antibodies and neutralizing titers, but the relative increase was significantly higher in non-infected individuals (n=63). In general, both groups showed higher neutralizing activity towards the parental strain than towards Omicron subvariants BA.1, BA.2 and BA.5. In contrast, CD4 or CD8 T-cell levels towards spike from the parental strain and the Omicron subvariants, and cytokine expression profiles were similar irrespective of prior infection. Breakthrough infections occurred more frequently among previously non-infected individuals, who had significantly lower vaccine-induced spike-specific neutralizing activity and CD4 T-cell levels. Thus, the magnitude of vaccine-induced neutralizing activity and specific CD4 T-cells after bivalent vaccination may serve as a correlate for protection in previously non-infected individuals.

Published
2023

31. Head-to-head analysis of immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens

Author

Sester, Martina, primary, Klemis, Verena, additional, Schmidt, Tina, additional, Schub, David, additional, Mihm, Janine, additional, Marx, Stefanie, additional, Abu-Omar, Amina, additional, Ziegler, Laura, additional, Hielscher, Franziska, additional, Guckelmus, Candida, additional, Urschel, Rebecca, additional, Wagenpfeil, Stefan, additional, Schneitler, Sophie, additional, Becker, Soeren, additional, Gärtner, Barbara, additional, and Sester, Urban, additional

Published
2021
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35. Immunogenicity and reactogenicity of a heterologous COVID-19 prime-boost vaccination compared with homologous vaccine regimens

Author

Schmidt, Tina, primary, Klemis, Verena, additional, Schub, David, additional, Mihm, Janine, additional, Hielscher, Franziska, additional, Marx, Stefanie, additional, Abu-Omar, Amina, additional, Schneitler, Sophie, additional, Becker, Sören L., additional, Gärtner, Barbara C., additional, Sester, Urban, additional, and Sester, Martina, additional

Published
2021
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37. Floating fungus balls in a blood culture bottle

Author

Schneitler, Sophie, Bub, Florian, Benthien, Sophia, Lepper, Philipp M., Kurzai, Oliver, Beaker, Soeren L., Roth, Sophie, Schneitler, Sophie, Bub, Florian, Benthien, Sophia, Lepper, Philipp M., Kurzai, Oliver, Beaker, Soeren L., and Roth, Sophie

Published
2021

43. High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

Author

Schub, David, primary, Klemis, Verena, additional, Schneitler, Sophie, additional, Mihm, Janine, additional, Lepper, Philipp M., additional, Wilkens, Heinrike, additional, Bals, Robert, additional, Eichler, Hermann, additional, Gärtner, Barbara C., additional, Becker, Sören L., additional, Sester, Urban, additional, Sester, Martina, additional, and Schmidt, Tina, additional

Published
2020
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44. High levels of SARS-CoV-2 specific T-cells with restricted functionality in patients with severe course of COVID-19

Author

Schub, David, primary, Klemis, Verena, additional, Schneitler, Sophie, additional, Mihm, Janine, additional, Lepper, Philipp M., additional, Wilkens, Heinrike, additional, Bals, Robert, additional, Eichler, Hermann, additional, Gärtner, Barbara C., additional, Becker, Sören L., additional, Sester, Urban, additional, Sester, Martina, additional, and Schmidt, Tina, additional

Published
2020
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47. Simple Questionnaires to Improve Pooling Strategies for SARS-CoV-2 Laboratory Testing

Author

Schneitler, Sophie, Jung, Philipp, Bub, Florian, Alhussein, Farah, Benthien, Sophia, Berger, Fabian K., Berko-Gottel, Barbara, Eisenbeis, Janina, Hahn, Daphne, Halfmann, Alexander, Last, Katharina, Linxweiler, Maximilian, Lohse, Stefan, Papan, Cihan, Pfuhl, Thorsten, Rissland, Jurgen, Roth, Sophie, Schlotthauer, Uwe, Utzinger, Jurg, Smola, Sigrun, Gartner, Barbara C., Becker, Soren L., Schneitler, Sophie, Jung, Philipp, Bub, Florian, Alhussein, Farah, Benthien, Sophia, Berger, Fabian K., Berko-Gottel, Barbara, Eisenbeis, Janina, Hahn, Daphne, Halfmann, Alexander, Last, Katharina, Linxweiler, Maximilian, Lohse, Stefan, Papan, Cihan, Pfuhl, Thorsten, Rissland, Jurgen, Roth, Sophie, Schlotthauer, Uwe, Utzinger, Jurg, Smola, Sigrun, Gartner, Barbara C., and Becker, Soren L.

Abstract

Background: Liberal PCR testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key to contain the coronavirus disease 2019 (COVID-19) pandemic. Combined multi-sample testing in pools instead of single tests might enhance laboratory capacity and reduce costs, especially in low- and middle-income countries. Objective: The purpose of our study was to assess the value of a simple questionnaire to guide and further improve pooling strategies for SARS-CoV-2 laboratory testing. Methods: Pharyngeal swabs for SARS-CoV-2 testing were obtained from healthcare and police staff, hospital inpatients, and nursing home residents in the southwestern part of Germany. We designed a simple questionnaire, which included questions pertaining to a suggestive clinical symptomatology, recent travel history, and contact with confirmed cases to stratify an individual's pre-test probability of having contracted COVID-19. The questionnaire was adapted repeatedly in face of the unfolding pandemic in response to the evolving epidemiology and observed clinical symptomatology. Based on the response patterns, samples were either tested individually or in multi-sample pools. We compared the pool positivity rate and the number of total PCR tests required to obtain individual results between this questionnaire-based pooling strategy and randomly assembled pools. Findings: Between March 11 and July 5, 2020, we processed 25,978 samples using random pooling (n = 6,012; 23.1%) or questionnaire-based pooling (n = 19,966; 76.9%). The overall prevalence of SARSCoV-2 was 0.9% (n = 238). Pool positivity (14.6% vs. 1.2%) and individual SARS-CoV-2 prevalence (3.4% vs. 0.1%) were higher in the random pooling group than in the questionnaire group. The average number of PCR tests needed to obtain the individual result for one participant was 0.27 tests in the random pooling group, as compared to 0.09 in the questionnaire-based pooling group, leading to a laboratory capacity increase of 73% and 9

Published
2020

48. Simple Questionnaires to Improve Pooling Strategies for SARS-CoV-2 Laboratory Testing

Author

Schneitler, Sophie, primary, Jung, Philipp, additional, Bub, Florian, additional, Alhussein, Farah, additional, Benthien, Sophia, additional, Berger, Fabian K., additional, Berkó-Göttel, Barbara, additional, Eisenbeis, Janina, additional, Hahn, Daphne, additional, Halfmann, Alexander, additional, Last, Katharina, additional, Linxweiler, Maximilian, additional, Lohse, Stefan, additional, Papan, Cihan, additional, Pfuhl, Thorsten, additional, Rissland, Jürgen, additional, Roth, Sophie, additional, Schlotthauer, Uwe, additional, Utzinger, Jürg, additional, Smola, Sigrun, additional, Gärtner, Barbara C., additional, and Becker, Sören L., additional

Published
2020
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