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27 results on '"Schneider, M. Bret"'

3. Dosimetric Comparison of Dedicated Radiosurgery Platforms for the Treatment of Essential Tremor: Technical Report

Author

Marianayagam, Neelan J, primary, Paddick, Ian, additional, Persad, Amit R, additional, Hori, Yusuke S, additional, Maslowski, Alexander, additional, Thirunarayanan, Ishwarya, additional, Khanna, Arjun R, additional, Park, David J, additional, Buch, Vivek, additional, Chang, Steven D., additional, Schneider, M. Bret, additional, Yu, Hong, additional, Weidlich, Georg A, additional, and Adler, John R., additional

Published
2024
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4. Experimental and Monte Carlo based dosimetric investigation of a novel 3 mm radiosurgery 3 MV beam using the microSilicon detector.

Author

Saße, Katrin, Albers, Karina, Klassen, Peter Douglas, Marianyagam, Neelan J., Weidlich, Georg, Schneider, M. Bret, Chang, Steven, Adler, John, Poppe, Björn, Looe, Hui Khee, and Eulenstein, Daniela

Subjects
PHOTON beams, MEDICAL dosimetry, CORRECTION factors, LINEAR accelerators, MONTE Carlo method, DETECTORS, RADIOSURGERY, INDUCTIVE effect
Abstract

Background: The ZAP‐X system is a novel gyroscopic radiosurgical system based on a 3 MV linear accelerator and collimator cones with a diameter between 4 and 25 mm. Advances in imaging modalities to detect small and early‐stage pathologies allow for an early and less invasive treatment, where a smaller collimator matching the anatomical target could provide better sparing of surrounding healthy tissue. Purpose: A novel 3 mm collimator cone for the ZAP‐X was developed. This study aims to investigate the usability of a commercial diode detector (microSilicon) for the dosimetric characterization of this small collimator cone; and to investigate the underlying small field perturbation effects. Methods: Profile measurements in five depths as well as PDD and output ratio measurements were performed with a microSilicon detector and radiochromic EBT3 films. In addition, comprehensive Monte Carlo simulations were performed to validate the measurement observations and to quantify the perturbation effects of the microSilicon detector in these extremely small field conditions. Results: It is shown that the microSilicon detector enables an accurate dosimetric characterization of the 3 mm beam. The profile parameters, such as the FWHM and 20%–80% penumbra width, agree within 0.1 to 0.2 mm between film and detector measurements. The output ratios agree within the measurement uncertainty between microSilicon detector and films, whereas the comparisons of the PDD results show good agreement with the Monte Carlo simulations. The analysis of the perturbation factors of the microSilicon detector reveals a small field correction factor of approximately 3% for the 3 mm circular beam and a correction factor smaller than 1.5% for field diameters above 3 mm. Conclusions: It could be shown that the microSilicon detector is well‐suitable for the characterization of the new 3 mm circular beam of the ZAP‐X system. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Non-ablative doses of focal ionizing radiation alters function of central neural circuits

Author

Zaer, Hamed, primary, Fan, Wei, additional, Orlowski, Dariusz, additional, Glud, Andreas N., additional, Jensen, Morten B., additional, Worm, Esben S., additional, Lukacova, Slávka, additional, Mikkelsen, Trine W., additional, Fitting, Lise M., additional, Jacobsen, Liisa M., additional, Portmann, Thomas, additional, Hsieh, Jui-Yi, additional, Noel, Christopher, additional, Weidlich, Georg, additional, Chung, Woody, additional, Riley, Patrick, additional, Jenkins, Cesare, additional, Adler, John R., additional, Schneider, M. Bret, additional, Sørensen, Jens Christian H., additional, and Stroh, Albrecht, additional

Published
2022
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12. An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

Author

Zaer, Hamed, primary, Deshmukh, Ashlesha, additional, Orlowski, Dariusz, additional, Fan, Wei, additional, Prouvot, Pierre-Hugues, additional, Glud, Andreas Nørgaard, additional, Jensen, Morten Bjørn, additional, Worm, Esben Schjødt, additional, Lukacova, Slávka, additional, Mikkelsen, Trine Werenberg, additional, Fitting, Lise Moberg, additional, Adler, John R., additional, Schneider, M. Bret, additional, Jensen, Martin Snejbjerg, additional, Fu, Quanhai, additional, Go, Vinson, additional, Morizio, James, additional, Sørensen, Jens Christian Hedemann, additional, and Stroh, Albrecht, additional

Published
2021
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24. Targeting and Readout Strategies for Fast Optical Neural Control In Vitro and In Vivo.

Author

Gradinaru, Viviana, Thompson, Kimberly R., Feng Zhang, Mogri, Murtaza, Kay, Kenneth, Schneider, M. Bret, and Deisseroth, Karl

Subjects
NEUROBIOLOGY, GENETICS, NEURONS, ANIMAL models in research, TECHNOLOGY
Abstract

The article focuses on an approach which combines both high speed and genetic targeting that is based on a family of rapid light-responsive microbial opsins (MOs) including halorhodopsins and channelrhodopsins. Accordingly, results acquired from MO work in animal models may inform novel clinical approaches. It mentions that novel tools, targeting techniques, and readout technologies will extend the usefulness of the MOs in bidirectional, reversible, and spatiotemporally precise control of activity in targeted neurons.

Published
2007
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