Search

Your search keyword '"Schmohl, Kathrin A."' showing total 39 results
Start Over Author "Schmohl, Kathrin A."
39 results on '"Schmohl, Kathrin A."'

7. Supplementary Data FS1 from Mesenchymal Stem Cell–mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice

Author

Kitzberger, Carolin, primary, Spellerberg, Rebekka, primary, Han, Yang, primary, Schmohl, Kathrin A., primary, Stauss, Christina, primary, Zach, Christian, primary, Kälin, Roland E., primary, Multhoff, Gabriele, primary, Eiber, Matthias, primary, Schilling, Franz, primary, Glass, Rainer, primary, Weber, Wolfgang A., primary, Wagner, Ernst, primary, Nelson, Peter J., primary, and Spitzweg, Christine, primary

Published
2023
Full Text
View/download PDF

8. Supplementary Figure S2 from Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell–Mediated Sodium Iodide Symporter (NIS) Gene 131I Therapy

Author

Schug, Christina, primary, Kitzberger, Carolin, primary, Sievert, Wolfgang, primary, Spellerberg, Rebekka, primary, Tutter, Mariella, primary, Schmohl, Kathrin A., primary, Eberlein, Bernadette, primary, Biedermann, Tilo, primary, Steiger, Katja, primary, Zach, Christian, primary, Schwaiger, Markus, primary, Multhoff, Gabriele, primary, Wagner, Ernst, primary, Nelson, Peter J., primary, and Spitzweg, Christine, primary

Published
2023
Full Text
View/download PDF

9. Mesenchymal Stem Cell–mediated Image-guided Sodium Iodide Symporter (NIS) Gene Therapy Improves Survival of Glioblastoma-bearing Mice

Author

Kitzberger, Carolin, primary, Spellerberg, Rebekka, additional, Han, Yang, additional, Schmohl, Kathrin A., additional, Stauss, Christina, additional, Zach, Christian, additional, Kälin, Roland E., additional, Multhoff, Gabriele, additional, Eiber, Matthias, additional, Schilling, Franz, additional, Glass, Rainer, additional, Weber, Wolfgang A., additional, Wagner, Ernst, additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2023
Full Text
View/download PDF

12. An unusual case of struma ovarii

Author

Koehler, Viktoria F, primary, Keller, Patrick, additional, Waldmann, Elisa, additional, Schwenk, Nathalie, additional, Kitzberger, Carolin, additional, Schmohl, Kathrin A, additional, Knösel, Thomas, additional, Stief, Christian Georg, additional, and Spitzweg, Christine, additional

Published
2021
Full Text
View/download PDF

17. Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells

Author

Tutter, Mariella, primary, Schug, Christina, additional, Schmohl, Kathrin A., additional, Urnauer, Sarah, additional, Schwenk, Nathalie, additional, Petrini, Matteo, additional, Lokerse, Wouter J. M., additional, Zach, Christian, additional, Ziegler, Sibylle, additional, Bartenstein, Peter, additional, Weber, Wolfgang A., additional, Wagner, Ernst, additional, Lindner, Lars H., additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2020
Full Text
View/download PDF

20. Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell–Mediated Sodium Iodide Symporter (NIS) Gene 131I Therapy

Author

Schug, Christina, primary, Kitzberger, Carolin, additional, Sievert, Wolfgang, additional, Spellerberg, Rebekka, additional, Tutter, Mariella, additional, Schmohl, Kathrin A., additional, Eberlein, Bernadette, additional, Biedermann, Tilo, additional, Steiger, Katja, additional, Zach, Christian, additional, Schwaiger, Markus, additional, Multhoff, Gabriele, additional, Wagner, Ernst, additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2019
Full Text
View/download PDF

22. SUN-339 External Beam Radiation Therapy Improves TGFB1-Induced Mesenchymal Stem Cell-Mediated NIS Gene 131I Therapy

Author

Schug, Christina, primary, Kitzberger, Carolin, additional, Sievert, Wolfgang, additional, Spellerberg, Rebekka, additional, Tutter, Mariella, additional, Schmohl, Kathrin, additional, Schwenk, Nathalie, additional, Schwaiger, Markus, additional, Multhoff, Gabriele, additional, Wagner, Ernst, additional, Nelson, Peter, additional, and Spitzweg, Christine, additional

Published
2019
Full Text
View/download PDF

23. TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer

Author

Schug, Christina, primary, Urnauer, Sarah, additional, Jaeckel, Carsten, additional, Schmohl, Kathrin A, additional, Tutter, Mariella, additional, Steiger, Katja, additional, Schwenk, Nathalie, additional, Schwaiger, Markus, additional, Wagner, Ernst, additional, Nelson, Peter J, additional, and Spitzweg, Christine, additional

Published
2019
Full Text
View/download PDF

24. A Novel Approach for Image-Guided 131I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery

Author

Schug, Christina, primary, Gupta, Aayush, additional, Urnauer, Sarah, additional, Steiger, Katja, additional, Cheung, Phyllis Fung-Yi, additional, Neander, Christian, additional, Savvatakis, Konstantinos, additional, Schmohl, Kathrin A., additional, Trajkovic-Arsic, Marija, additional, Schwenk, Nathalie, additional, Schwaiger, Markus, additional, Nelson, Peter J., additional, Siveke, Jens T., additional, and Spitzweg, Christine, additional

Published
2019
Full Text
View/download PDF

25. Thyroid Hormone Effects on Mesenchymal Stem Cell Biology in the Tumour Microenvironment.

Author

Schmohl, Kathrin Alexandra, Müller, Andrea Maria, Nelson, Peter Jon, and Spitzweg, Christine

Subjects
*MESENCHYMAL stem cells, *CYTOLOGY, *THYROID hormones, *CELL receptors, *MESENCHYMAL stem cell differentiation
Abstract

Non-classical thyroid hormone signalling via cell surface receptor integrin αvβ3, expressed on most cancer cells and proliferating endothelial cells, has been shown to drive tumour cell proliferation and survival, as well as angiogenesis. Tumours develop within a complex microenvironment that is composed of many different cell types, including mesenchymal stem cells. These multipotent progenitor cells actively home to growing tumours where they differentiate into cancer-associated fibroblast-like cells and blood vessel-stabilising pericytes and thus support the tumour's fibrovascular network. Integrin αvβ3 expression on mesenchymal stem cells makes them susceptible to thyroid hormone stimulation. Indeed, our studies demonstrated – for the first time – that thyroid hormones stimulate the differentiation of mesenchymal stem cells towards a carcinoma-associated fibroblast-/pericyte-like and hypoxia-responsive, pro-angiogenic phenotype, characterised by the secretion of numerous paracrine pro-angiogenic factors, in addition to driving their migration, invasion, and recruitment to the tumour microenvironment in an experimental hepatocellular carcinoma model. The deaminated thyroid hormone metabolite tetrac, a specific inhibitor of thyroid hormone action at the integrin site, reverses these effects. The modulation of mesenchymal stem cell signalling and recruitment by thyroid hormones via integrin αvβ3 adds a further layer to the multifaceted effects of thyroid hormones on tumour progression, with important implications for the management of cancer patients and suggests a novel mechanism for the anti-tumour activity of tetrac. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

26. External Beam Radiation Therapy Enhances Mesenchymal Stem Cell–Mediated Sodium–Iodide Symporter Gene Delivery

Author

Schug, Christina, primary, Sievert, Wolfgang, additional, Urnauer, Sarah, additional, Müller, Andrea M., additional, Schmohl, Kathrin A., additional, Wechselberger, Alexandra, additional, Schwenk, Nathalie, additional, Lauber, Kirsten, additional, Schwaiger, Markus, additional, Multhoff, Gabriele, additional, Wagner, Ernst, additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2018
Full Text
View/download PDF

30. EGFR-targeted nonviral NIS gene transfer for bioimaging and therapy of disseminated colon cancer metastases

Author

Urnauer, Sarah, primary, Müller, Andrea M., additional, Schug, Christina, additional, Schmohl, Kathrin A., additional, Tutter, Mariella, additional, Schwenk, Nathalie, additional, Rödl, Wolfgang, additional, Morys, Stephan, additional, Ingrisch, Michael, additional, Bertram, Jens, additional, Bartenstein, Peter, additional, Clevert, Dirk-André, additional, Wagner, Ernst, additional, and Spitzweg, Christine, additional

Published
2017
Full Text
View/download PDF

31. Imaging and targeted therapy of pancreatic ductal adenocarcinoma using the theranostic sodium iodide symporter (NIS) gene

Author

Schmohl, Kathrin A., primary, Gupta, Aayush, additional, Grünwald, Geoffrey K., additional, Trajkovic-Arsic, Marija, additional, Klutz, Kathrin, additional, Braren, Rickmer, additional, Schwaiger, Markus, additional, Nelson, Peter J., additional, Ogris, Manfred, additional, Wagner, Ernst, additional, Siveke, Jens T., additional, and Spitzweg, Christine, additional

Published
2017
Full Text
View/download PDF

32. Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery

Author

Müller, Andrea M., primary, Schmohl, Kathrin A., additional, Knoop, Kerstin, additional, Schug, Christina, additional, Urnauer, Sarah, additional, Hagenhoff, Anna, additional, Clevert, Dirk-André, additional, Ingrisch, Michael, additional, Niess, Hanno, additional, Carlsen, Janette, additional, Zach, Christian, additional, Wagner, Ernst, additional, Bartenstein, Peter, additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2016
Full Text
View/download PDF

34. Sequence defined cMET/HGFR-targeted polymers as gene delivery vehicles for the theranostic sodium iodide symporter (NIS) gene

Author

Urnauer, Sarah, primary, Morys, Stephan, additional, Levacic, Ana Krhac, additional, Muller, Andrea M, additional, Schug, Christina, additional, Schmohl, Kathrin A, additional, Schwenk, Nathalie, additional, Zach, Christian, additional, Carlsen, Janette, additional, Bartenstein, Peter, additional, Wagner, Ernst, additional, and Spitzweg, Christine, additional

Published
2016
Full Text
View/download PDF

37. Mesenchymal Stem Cell–Mediated, Tumor Stroma–Targeted Radioiodine Therapy of Metastatic Colon Cancer Using the Sodium Iodide Symporter as Theranostic Gene

Author

Knoop, Kerstin, primary, Schwenk, Nathalie, additional, Schmohl, Kathrin, additional, Müller, Andrea, additional, Zach, Christian, additional, Cyran, Clemens, additional, Carlsen, Janette, additional, Böning, Guido, additional, Bartenstein, Peter, additional, Göke, Burkhard, additional, Wagner, Ernst, additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2015
Full Text
View/download PDF

38. Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell-Mediated Sodium Iodide Symporter ( NIS ) Gene 131 I Therapy.

Author

Schug C, Kitzberger C, Sievert W, Spellerberg R, Tutter M, Schmohl KA, Eberlein B, Biedermann T, Steiger K, Zach C, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, and Spitzweg C

Subjects
Animals, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular pathology, Cell Line, Tumor, Female, Humans, Liver Neoplasms genetics, Liver Neoplasms metabolism, Liver Neoplasms pathology, Mesenchymal Stem Cells metabolism, Mesenchymal Stem Cells radiation effects, Mice, Mice, Nude, Radionuclide Imaging methods, Transforming Growth Factor beta1 genetics, Transforming Growth Factor beta1 radiation effects, Transgenes, Xenograft Model Antitumor Assays, Carcinoma, Hepatocellular therapy, Genetic Therapy methods, Iodine Radioisotopes pharmacology, Liver Neoplasms therapy, Mesenchymal Stem Cells cytology, Symporters genetics, Transforming Growth Factor beta1 metabolism
Abstract

Purpose: The innate tumor homing potential of mesenchymal stem cells (MSCs) has been used for a targeted delivery of the theranostic sodium iodide symporter ( NIS ) transgene into solid tumors. We have previously shown that external beam radiotherapy (EBRT) results in the enhanced recruitment of NIS- expressing MSCs into human hepatocellular carcinoma (HuH7). In parallel, the tumor-associated cytokine TGFB1 becomes strongly upregulated in HuH7 tumors in response to EBRT., Experimental Design: We therefore evaluated the effects of combining focused EBRT (5 Gy) with MSC-mediated systemic delivery of the theranostic NIS transgene under control of a synthetic TGFB1-inducible SMAD-responsive promoter (SMAD-NIS-MSCs) using 123 I-scintigraphy followed by 131 I therapy in CD1 nu/nu mice harboring subcutaneous human hepatocellular carcinoma (HuH7)., Results: Following tumor irradiation and SMAD-NIS-MSC application, tumoral iodide uptake monitored in vivo by 123 I-scintigraphy was enhanced as compared with nonirradiated tumors. Combination of EBRT and SMAD-NIS-MSC-mediated 131 I therapy resulted in a significantly improved delay in tumor growth and prolonged survival in therapy mice as compared with the combined therapy using CMV-NIS-MSCs or to control groups receiving EBRT or saline only, or EBRT together with SMAD-NIS-MSCs and saline applications., Conclusions: MSC-based NIS-mediated 131 I therapy after EBRT treatment dramatically enhanced therapeutic efficacy when a TGFB1-inducible SMAD-responsive promoter was used to drive NIS expression in adoptively applied MSCs. The remarkable therapeutic effect seen is thought to be linked in large part to the enhanced TGFB1 produced in this context, which leads to a highly selective and focused amplification of MSC-based NIS expression within the tumor milieu., (©2019 American Association for Cancer Research.)

Published
2019
Full Text
View/download PDF

39. A Novel Approach for Image-Guided 131 I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery.

Author

Schug C, Gupta A, Urnauer S, Steiger K, Cheung PF, Neander C, Savvatakis K, Schmohl KA, Trajkovic-Arsic M, Schwenk N, Schwaiger M, Nelson PJ, Siveke JT, and Spitzweg C

Subjects
Animals, Carcinoma, Pancreatic Ductal pathology, Carcinoma, Pancreatic Ductal radiotherapy, Cell Line, Cell Line, Tumor, Female, Humans, Male, Mesenchymal Stem Cells cytology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Pancreatic Neoplasms pathology, Pancreatic Neoplasms radiotherapy, Positron-Emission Tomography methods, Transfection, Carcinoma, Pancreatic Ductal diagnostic imaging, Carcinoma, Pancreatic Ductal therapy, Gene Transfer Techniques, Iodine Radioisotopes administration & dosage, Mesenchymal Stem Cell Transplantation methods, Mesenchymal Stem Cells physiology, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms therapy
Abstract

The sodium iodide symporter ( SLC5A5/NIS ) as theranostic gene would allow for non-invasive imaging of functional NIS expression and therapeutic radioiodine application. Genetically engineered mesenchymal stem cells (MSC), based on their tumor-homing abilities, show great promise as tumor-selective NIS gene delivery vehicles for non-thyroidal tumors. As a next step towards clinical application, tumor specificity and efficacy of MSCs were investigated in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC). Syngeneic murine MSCs were stably transfected with a NIS -expressing plasmid driven by the CMV -promoter (NIS-MSC). In vivo 123 I-PET revealed significant perchlorate-sensitive NIS-mediated radioiodide accumulation in PDAC after systemic injection of NIS-MSCs. Active MSC recruitment into the tumor stroma was confirmed using NIS immunohistochemistry (IHC). A therapeutic strategy, consisting of three cycles of systemic MSC-mediated 124 I-PET revealed significant perchlorate-sensitive NIS-mediated radioiodide accumulation in PDAC after systemic injection of NIS-MSCs. Active MSC recruitment into the tumor stroma was confirmed using NIS immunohistochemistry (IHC). A therapeutic strategy, consisting of three cycles of systemic MSC-mediated NIS I application, resulted in a significant delay and reduction in tumor growth as compared to controls. Furthermore, IHC analysis of α-SMA and Ki67 revealed differences in the amount and behavior of activated fibroblasts in tumors of mice injected with NIS-MSCs as compared with saline-treated mice. Taken together, MSCs as 131 I application, resulted in a significant delay and reduction in tumor growth as compared to controls. Furthermore, IHC analysis of α-SMA and Ki67 revealed differences in the amount and behavior of activated fibroblasts in tumors of mice injected with NIS-MSCs as compared with saline-treated mice. Taken together, MSCs as NIS I therapeutic effect. IMPLICATIONS: These data expand the prospect of MSC-mediated radioiodine imaging-guided therapy of pancreatic cancer using the sodium iodide symporter as a theranostic gene in a clinical setting.131 I therapeutic effect. IMPLICATIONS: These data expand the prospect of MSC-mediated radioiodine imaging-guided therapy of pancreatic cancer using the sodium iodide symporter as a theranostic gene in a clinical setting., (©2018 American Association for Cancer Research.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results