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9. Republication de : recommandations formalisées d’experts. Prise en charge de la patiente avec une pré-éclampsie sévère–RFE communes Société française d’anesthésie-réanimation (SFAR)–Collège national des gynécologues et obstétriciens français (CGNOF)

Author

Bonnet, M.-P., Garnier, M., Keita, H., Compere, V., Arthuis, C., Raia-Barjat, T., Berveiller, P., Burey, J., Bouvet, L., Bruyère, M., Castel, A., Clouqueur, E., Estevez, M. Gonzalez, Faitot, V., Fischer, C., Fuchs, F., Lecarpentier, E., Le Gouez, A., Rigouzzo, A., Rossignol, M., Simon, E., Vial, F., Vivanti, A.J., Zieleskewicz, L., Sénat, M.-V., Schmitz, T., and Sentilhes, L.

Published
2022
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16. Potential of notochordal cells within injectable biomaterials to promote intervertebral disc regeneration

Author

Williams, R. J., Basatvat, S., Schmitz, T. C., Janani, R., Sammon, C., Benz, K., Ito, K., Tryfonidou, M. A., Snuggs, J. W., Le Maitre, C. L., Williams, R. J., Basatvat, S., Schmitz, T. C., Janani, R., Sammon, C., Benz, K., Ito, K., Tryfonidou, M. A., Snuggs, J. W., and Le Maitre, C. L.

Abstract

Low back pain is the leading cause of disability worldwide and is strongly associated with degeneration of the intervertebral disc (IVD).During degeneration the nucleus pulposus (NP) in the core of the IVD, is affected by altered matrix synthesis, increased degradation, andcell loss. Strategies combining regenerative cell sources with injectable biomaterials could provide a therapeutic approach to treatingIVD-degeneration related back pain. The juvenile cells of the NP, known as notochordal cells (NC), could provide both anabolic andanti-catabolic responses for disc regeneration. However, their behaviour within biomaterial delivery systems has not been investigated.Here, porcine NCs were incorporated into three injectable hydrogels: Albugel (an albumin/hyaluronan hydrogel), NPgel (a L-pNIPAMco-DMAc hydrogel) and NPgel with decellularized NC-matrix powder (dNCM). The NCs and biomaterial constructs were cultured for upto 4 weeks under 5% oxygen (n = 3 biological repeats). The ability of biomaterials to maintain NC viability, phenotype and extracellularmatrix synthesis and deposition was investigated through histological, immunohisto chemical and glycosaminogly cans analysis. NCs survived in all three biomaterials after 4 weeks, whilst phenotype and cell clustering were maintained to a greater extent in NPgel and Albugel. Thus, these biomaterials could facilitate maintenance of the NC phenotype, support matrix deposition and be a basis for future IVD regeneration strategies.

Published
2024

17. Potential of notochordal cells within injectable biomaterials to promote intervertebral disc regeneration

Author

Chirurgie, CS_Locomotion, Locomotion - Surgery (CA), Williams, R. J., Basatvat, S., Schmitz, T. C., Janani, R., Sammon, C., Benz, K., Ito, K., Tryfonidou, M. A., Snuggs, J. W., Le Maitre, C. L., Chirurgie, CS_Locomotion, Locomotion - Surgery (CA), Williams, R. J., Basatvat, S., Schmitz, T. C., Janani, R., Sammon, C., Benz, K., Ito, K., Tryfonidou, M. A., Snuggs, J. W., and Le Maitre, C. L.

Published
2024

18. Accouchement normal : accompagnement de la physiologie et interventions médicales. Recommandations de la Haute Autorité de Santé (HAS) avec la collaboration du Collège National des Gynécologues Obstétriciens Français (CNGOF) et du Collège National des Sages-Femmes de France (CNSF) – Texte des recommandations (texte court)

Author

Petitprez, K., Guillaume, S., Mattuizzi, A., Arnal, M., Artzner, F., Bernard, C., Bonnin, M., Bouvet, L., Caron, F.-M., Chevalier, I., Daussy-Urvoy, C., Ducloy-Bouthorsc, A.-S., Garnier, J.-M., Keita-Meyer, H., Lavillonnière, J., Lejeune-Sadaa, V., Leray, C., Morandeau, A., Morau, E., Nadjafizade, M., Pizzagalli, F., Schantz, C., Schmitz, T., Shojai, R., Hédon, B., and Sentilhes, L.

Published
2020
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29. Recommandations pour la pratique clinique : prévention de la prématurité spontanée et de ses conséquences (hors rupture des membranes) — Texte des recommandations (texte court)

Author

Sentilhes, L., Sénat, M.-V., Ancel, P.-Y., Azria, E., Benoist, G., Blanc, J., Brabant, G., Bretelle, F., Brun, S., Doret, M., Ducroux-Schouwey, C., Evrard, A., Kayem, G., Maisonneuve, E., Marcellin, L., Marret, S., Mottet, N., Paysant, S., Riethmuller, D., Rozenberg, P., Schmitz, T., Torchin, H., and Langer, B.

Published
2017
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32. Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation

Author

Salzer, Elias, Schmitz, T C, Mouser, V Hm, Vernengo, A, Gantenbein, B, Jansen, J U, Neidlinger-Wilke, C, Wilke, H-J, Grad, S, Le Maitre, C L, Tryfonidou, M A, Ito, Keita, Salzer, Elias, Schmitz, T C, Mouser, V Hm, Vernengo, A, Gantenbein, B, Jansen, J U, Neidlinger-Wilke, C, Wilke, H-J, Grad, S, Le Maitre, C L, Tryfonidou, M A, and Ito, Keita

Abstract

Because low back pain is frequently a result of intervertebral disc degeneration (IVDD), strategies to regenerate or repair the IVD are currently being investigated. Often, ex vivo disc cultures of non-human IVD organs or tissue explants are used that usually do not exhibit natural IVDD. Therefore, degenerative changes mimicking those reported in human IVDD need to be induced. To support researchers in selecting ex vivo disc cultures, a systematic search was performed for them and their potential use for studying human IVDD reviewed. Five degeneration induction categories (proinflammatory cytokines, injury/damage, degenerative loading, enzyme, and other) were identified in 129 studies across 7 species. Methods to induce degeneration are diverse and can induce mild to severe degenerative changes that progress over time, as described for human IVDD. The induced degenerative changes are model-specific and there is no "one-fits-all" IVDD induction method. Nevertheless, specific aspects of human IVDD can be well mimicked. Currently, spontaneously degenerated disc cultures from large animals capture human IVDD in most aspects. Combinatorial approaches of several induction methods using discs derived from large animals are promising to recapitulate pathological changes on several levels, such as cellular behaviour, extracellular matrix composition, and biomechanical function, and therefore better mimic human IVDD. Future disc culture setups might increase in complexity, and mimic human IVDD even better. As ex vivo disc cultures have the potential to reduce and even replace animal trials, especially during preclinical development, advancement of such models is highly relevant for more efficient and cost-effective clinical translation from bench-to-bedside.

Published
2023

33. Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation

Author

Chirurgie, CS_Locomotion, Salzer, Elias, Schmitz, T C, Mouser, V Hm, Vernengo, A, Gantenbein, B, Jansen, J U, Neidlinger-Wilke, C, Wilke, H-J, Grad, S, Le Maitre, C L, Tryfonidou, M A, Ito, Keita, Chirurgie, CS_Locomotion, Salzer, Elias, Schmitz, T C, Mouser, V Hm, Vernengo, A, Gantenbein, B, Jansen, J U, Neidlinger-Wilke, C, Wilke, H-J, Grad, S, Le Maitre, C L, Tryfonidou, M A, and Ito, Keita

Published
2023

34. NOTOCHORDAL CELL-DERIVED MATRIX INHIBITS MAPK SIGNALING IN THE DEGENERATIVE DISC ENVIRONMENT

Author

Orthopaedie Onderzoek, ORT Research, Regenerative Medicine and Stem Cells, Laagland, L. T., Bach, F. C., Riemers, F. M., Erdmann, G., Braun, T. S., van den Akker, G. G.H., Schmitz, T. C., Creemers, L. B., Sachse, C., Maitre, C. L.Le, Welting, T. J.M., Ito, K., Templin, M. F., Tryfonidou, Marianna A., Orthopaedie Onderzoek, ORT Research, Regenerative Medicine and Stem Cells, Laagland, L. T., Bach, F. C., Riemers, F. M., Erdmann, G., Braun, T. S., van den Akker, G. G.H., Schmitz, T. C., Creemers, L. B., Sachse, C., Maitre, C. L.Le, Welting, T. J.M., Ito, K., Templin, M. F., and Tryfonidou, Marianna A.

Published
2023

40. Probabilistische Modellierung und Vorhersage der Standzeit und Zuverlässigkeit eines Fräswerkzeugs mittels der Bayesianischen Statistik

Author

Salehi, M., Wald, G., Schmitz, T. L., Haas, R., and Ovtcharova, J.

Abstract

In diesem Artikel wird die probabilistische Modellierung und Vorhersage für die Standzeit und Zuverlässigkeit eines Fräswerkzeugs mittels der Bayesianischen Statistik beschrieben. Zur Entwicklung des probabilistischen Modells wird eine Markov-Chain-Monte-Carlo-Simulation (MCMC) auf das Taylor-Standzeit-Modell angewendet. Die A‑priori-Wahrscheinlichkeitsverteilungen werden aus der Literaturrecherche ermittelt. Aus anschließenden Fräsversuchen werden ein Trainings- und ein Testdatensatz generiert. Die Versuche werden in einem Bereich der Schnittgeschwindigkeiten von 300 bis 400 m/min durchgeführt. Die A‑posteriori-Wahrscheinlichkeitsverteilungen werden unter Verwendung des Trainingssatzes berechnet. Mittels der trainierten A‑posteriori-Wahrscheinlichkeitsverteilungen werden anschließend die Testdatensätze bei den Schnittgeschwindigkeiten von 300 bis 400 m/min vorhergesagt. Es folgt ein Vergleich des probabilistischen Standzeitmodells mit den Testdatensätzen. Anschließend werden die A‑posteriori-Verteilungen der Werkzeugstandzeit verwendet, um eine Zuverlässigkeitsanalyse unter Verwendung der Zuverlässigkeitsfunktion in Abhängigkeit der Schnittgeschwindigkeit durchzuführen. Es wird gezeigt, dass die Werkzeugstandzeit- und Zuverlässigkeitsfunktion die gemessenen Werkzeugstandzeiten innerhalb der Unsicherheitsintervalle mit einem maximalen Vorhersagefehler von 18 % mit lediglich zwei Trainingsdatenpunkten vorhersagen können.

Published
2024
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48. COVID-19 risk perceptions, worries and preventive behaviors in patients with previous myocardial infarction: results from the myocardial infarction registry Augsburg.

Author

Harmel, E., Schmitz, T., Meisinger, C., Linseisen, J., von Scheidt, W., Thilo, C., and Kirchberger, I.

Subjects
*MYOCARDIAL infarction complications, *RESEARCH, *MEDICAL quality control, *COVID-19, *SCIENTIFIC observation, *HEALTH services accessibility, *ATTITUDE (Psychology), *CROSS-sectional method, *FISHER exact test, *RISK perception, *HEALTH literacy, *PREVENTIVE health services, *RISK assessment, *COMPARATIVE studies, *T-test (Statistics), *PATIENTS' attitudes, *HEALTH attitudes, *HEALTH behavior, *DESCRIPTIVE statistics, *QUESTIONNAIRES, *CHI-squared test, *STATISTICAL correlation, *PSYCHOLOGICAL adaptation, *PATIENT compliance, *DATA analysis software, *SOCIODEMOGRAPHIC factors, *LONGITUDINAL method
Abstract

Despite the known association of chronic cardiovascular diseases and more severe courses of COVID-19, little is known about individual risk perception of patients with a history of acute myocardial infarction (AMI) and resulting preventive behaviours. In May 2020, a postal survey was conducted, including 150 patients with previous AMI from the myocardial infarction registry Augsburg. The study objective was to assess COVID-19 knowledge, individual risk perception, worries, infection likelihood and preventive behaviours in this patient cohort. From the 100 respondents, 69.7% perceived themselves to be at high risk of developing a severe course of COVID-19. There was a significant positive correlation between dangerousness assessment and knowledge on COVID-19. Despite a majority (70%) of patients rating their susceptibility for an infection as moderate to very high, the individual likelihood of being infected was rated at only 3%. Almost 70% of patients with previous MI classified themselves at high risk for a severe course of COVID-19 infection. As seen in other risk groups as well, the availability of valuable information sources as well as the support in individual risk reduction strategies and psychological coping mechanisms are mandatory, especially since higher knowledge correlates with dangerousness assessment and might lead to better compliance with preventive behaviours. [ABSTRACT FROM AUTHOR]

Published
2023
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