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37. Intact parathyroid hormone in primary hyperparathyroidism

Author

Flentje, D., Schmidt-Gayk, H., Fisher, S., Stern, J., Blind, E., Buhr, H., and Herfarth, Ch.

Subjects
Parathyroid hormone -- Measurement, Hypercalcemia -- Diagnosis, Hyperparathyroidism -- Cases, Health
Abstract

Primary hyperparathyroidism is a condition of abnormally overactive parathyroid glands resulting in increased loss of calcium from the bones with increased absorption of calcium by the kidneys and intestines. The usual cause of primary hyperparathyroidism is adenoma (glandular tumor) of one of the parathyroid glands. Diagnosis is made by laboratory findings of elevated parathyroid hormone levels in the blood. Diagnosis of this condition can be difficult when there is clinical evidence of the disease, but the parathyroid hormone levels are normal. Current assay techniques evaluate fragments of the parathyroid hormone molecule, which results in considerable overlap between normal subjects and hyperparathyroid patients. A new technique has been developed that evaluated intact parathyroid hormone. A report is presented of 49 patients with primary hyperparathyroidism who were tested using these two techniques. Measurements of intact parathyroid hormone in 47 normal subjects was determined to range from 2.0 to 6.8; the patient group values ranged from 6.4 to 89. The measurement of parathyroid hormone fragments was found to be normal in 7 of the 49 patients with confirmed hyperparathyroidism. Intraoperative monitoring of intact parathyroid hormone revealed a different pattern of decline for single adenomas compared with parathyroid hyperplasia (abnormal cell growth). It is concluded that measuring intact parathyroid hormone in patients with primary hyperparathyroidism is more accurate to measuring parathyroid hormone fragments. Monitoring of intact parathyroid hormone during surgery may be helpful in determining the success of surgery; decreases suggest successful surgery. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

50. Postersession IV : Gastroenterologie

Author

Kurtz, W., Classen, M., Schmidt, H., Riddell, R. H., Walther, B., Riemann, J. F., Raedsch, R., Stiehl, A., Sieg, A., Walker, S., Kommerell, B., Gregor, M., Hartmann, K., Riecken, E. O., Dammann, H. G., Walter, Th. A., Müller, P., Simon, B., Fölsch, U. R., Wichmann, G.-Ch., v. Kleist, E., Körber, R., Dillon, M., Clowdus, B., Creutzfeldt, W., Singer, M. V., Calden, H., Eysselein, V. E., Leffmann, C., Goebell, H., Müller-Lissner, St. A., Störkel, S., Dienes, H. P., Schneider, H.-M., Loos, M., Emde, C., Göring, M., Liehr, R.-M., Kruis, W., Azpiroz, F., Phillips, S. F., Stöcker, W., Ulrich, S., Normann, D., Stöcker, K., Jantschek, G., Otte, M., Seyfarth, K., Bührer, Ch., Winkler, R., Raedler, A., Malchow, H., Hoffmann, R., Daiss, W., Jenss, H., Dölle, W., Purrmann, J., Bertrams, J., Rietzler, M., Wolf, E., Miller, B., Strohmeÿer, G., Göke, B., Schwartz, P., Rahlf, G., Goerg, K. J., Wanitschke, R., Breiling, K., Franke, M., Rabast, U., Kemkes-Matthes, B., Abermann, C., Matthes, K. J., Schulzke, J.-D., Fromm, M., Menge, H., Löffler, A., Dienst, C., Thon, H. J., Wüstenberg, E., Corman, G., von Kachel, G., Ruppin, H., Hagel, J., Barina, W., Meinhardt, M., Domschke, W., Sandforth, F., Gutschmidt, S., Karbach, U., Rummel, W., Seitz, H. K., Feurle, G., Huefner, M., Lichtwald, K., Schmidt-Gayk, H., Janisch, H. D., Beuth, A., von Kleist, D., Bauer, F. E., Hampel, K. E., Blasberg, M., Wienbeck, M., Körner, M., Erckenbrecht, J. F., Berges, W., Miehlke, Klaus, editor, and Bergmann, J. F.

Published
1984
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