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6. Imidazolium salts are effective for the control of Culex quinquefasciatus larvae and demonstrate low impact on non-target organisms

Author

Pilz-Júnior, Harry Luiz, Jansen, Stephanie, Silva, Carolina Maicá, Gomes, Juliana Fank, Volz, Débora Rech, de Lemos, Alessandra Bittencourt, da Silva, Wellington Junior, Milagres, Tarcisio Freitas, Prophiro, Josiane Somariva, Schmidt-Chanasit, Jonas, Ziulkoski, Ana Luiza, Dallegrave, Eliane, Schrekker, Henri Stephan, Corção, Gertrudes, and da Silva, Onilda Santos

Published
2024
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21. Larval Competition between Aedes and Culex Mosquitoes Carries over to Higher Arboviral Infection during Their Adult Stage.

Author

Vanslembrouck, Adwine, Jansen, Stephanie, De Witte, Jacobus, Janssens, Corneel, Vereecken, Stien, Helms, Michelle, Lange, Unchana, Lühken, Renke, Schmidt-Chanasit, Jonas, Heitmann, Anna, and Müller, Ruth

Subjects
CULEX pipiens, JAPANESE encephalitis viruses, AEDES albopictus, WEST Nile virus, WEST Nile fever, ARBOVIRUS diseases
Abstract

The common house mosquito (Culex pipiens) is a native vector for West Nile virus (WNV). Invasive species like the tiger mosquito (Aedes albopictus) and Asian bush mosquito (Aedes japonicus) are rapidly spreading through Europe, posing a major threat as vectors for dengue, chikungunya (CHIKV), and Japanese encephalitis virus (JEV). These mosquitoes share a similar ecological niche as larvae, but the carry-over effects of aquatic larval interactions to the terrestrial adult stage remain largely unknown and their medical relevance requires further investigation. This study examines the context dependency of larval interactions among Aedes albopictus, Aedes japonicus, and Culex pipiens. The survival, development time, growth, and energetic storage were measured in different European populations within density-response (intraspecific) experiments and replacement (interspecific) experiments at 20 °C and 26 °C. Overall, Ae. japonicus was the weakest competitor, while competition between Ae. albopictus and Cx. pipiens varied with temperature. Adults emerging from this larval competition were infected as follows: Culex pipiens with WNV, Ae. albopictus with CHIKV, and Ae. japonicus with JEV. While no JEV infection was observed, mosquitoes experiencing interspecific interactions during their larval stages exhibited higher infection rates and viral RNA titers for CHIKV and WNV. This increased susceptibility to viral infection after larval competition suggests a higher risk of arbovirus transmission in co-occurring populations. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Semen inhibits Zika virus infection of cells and tissues from the anogenital region.

Author

Müller, Janis A, Harms, Mirja, Krüger, Franziska, Groß, Rüdiger, Joas, Simone, Hayn, Manuel, Dietz, Andrea N, Lippold, Sina, von Einem, Jens, Schubert, Axel, Michel, Manuela, Mayer, Benjamin, Cortese, Mirko, Jang, Karen S, Sandi-Monroy, Nathallie, Deniz, Miriam, Ebner, Florian, Vapalahti, Olli, Otto, Markus, Bartenschlager, Ralf, Herbeuval, Jean-Philippe, Schmidt-Chanasit, Jonas, Roan, Nadia R, and Münch, Jan

Subjects
Genitalia, Cell Line, Tumor, Vero Cells, Fibroblasts, Semen, Animals, Cercopithecus aethiops, Humans, Sexually Transmitted Diseases, Viral, RNA, Viral, Viral Load, Inhibitory Concentration 50, Virus Replication, Female, Male, Virus Attachment, Primary Cell Culture, Healthy Volunteers, Extracellular Vesicles, Zika Virus, Zika Virus Infection, Chlorocebus aethiops, Cell Line, Tumor, RNA, Viral, Sexually Transmitted Diseases
Abstract

Zika virus (ZIKV) causes severe birth defects and can be transmitted via sexual intercourse. Semen from ZIKV-infected individuals contains high viral loads and may therefore serve as an important vector for virus transmission. Here we analyze the effect of semen on ZIKV infection of cells and tissues derived from the anogenital region. ZIKV replicates in all analyzed cell lines, primary cells, and endometrial or vaginal tissues. However, in the presence of semen, infection by ZIKV and other flaviviruses is potently inhibited. We show that semen prevents ZIKV attachment to target cells, and that an extracellular vesicle preparation from semen is responsible for this anti-ZIKV activity. Our findings suggest that ZIKV transmission is limited by semen. As such, semen appears to serve as a protector against sexual ZIKV transmission, despite the availability of highly susceptible cells in the anogenital tract and high viral loads in this bodily fluid.

Published
2018

23. The molecular tweezer CLR01 inhibits Ebola and Zika virus infection

Author

Röcker, Annika E, Müller, Janis A, Dietzel, Erik, Harms, Mirja, Krüger, Franziska, Heid, Christian, Sowislok, Andrea, Riber, Camilla Frich, Kupke, Alexandra, Lippold, Sina, von Einem, Jens, Beer, Judith, Knöll, Bernd, Becker, Stephan, Schmidt-Chanasit, Jonas, Otto, Markus, Vapalahti, Olli, Zelikin, Alexander N, Bitan, Gal, Schrader, Thomas, and Münch, Jan

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Infectious Diseases, Vaccine Related, Prevention, Emerging Infectious Diseases, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Animals, Antiviral Agents, Bridged-Ring Compounds, Cell Line, Chlorocebus aethiops, Ebolavirus, Hemorrhagic Fever, Ebola, Humans, Organophosphates, Vero Cells, Virus Replication, Zika Virus, Zika Virus Infection, Zika virus, Ebola virus, Broadly active antiviral agents, Virus inactivation, Lipid rafts, Microbiology, Pharmacology and Pharmaceutical Sciences, Virology, Medical microbiology, Pharmacology and pharmaceutical sciences
Abstract

Ebola (EBOV) and Zika viruses (ZIKV) are responsible for recent global health threats. As no preventive vaccines or antiviral drugs against these two re-emerging pathogens are available, we evaluated whether the molecular tweezer CLR01 may inhibit EBOV and ZIKV infection. This small molecule has previously been shown to inactivate HIV-1 and herpes viruses through a selective interaction with lipid-raft-rich regions in the viral envelope, which results in membrane disruption and loss of infectivity. We found that CLR01 indeed blocked infection of EBOV and ZIKV in a dose-dependent manner. The tweezer inhibited infection of epidemic ZIKV strains in cells derived from the anogenital tract and the central nervous system, and remained antivirally active in the presence of semen, saliva, urine and cerebrospinal fluid. Our findings show that CLR01 is a broad-spectrum inhibitor of enveloped viruses with prospects as a preventative microbicide or antiviral agent.

Published
2018

27. Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018-2020

Author

Eisermann, Philip, Rubbenstroth, Dennis, Cadar, Daniel, Thome-Bolduan, Corinna, Eggert, Petra, Schlaphof, Alexander, Leypoldt, Frank, Stangel, Martin, Fortwangler, Thorsten, Hoffmann, Florian, Osterman, Andreas, Zange, Sabine, Niller, Hans-Helmut, Angstwurm, Klemens, Portner, Kirsten, Frank, Christina, Wilking, Hendrik, Beer, Martin, Schmidt-Chanasit, Jonas, and Tappe, Dennis

Subjects
Encephalitis -- Case studies -- Causes of, RNA virus infections -- Case studies -- Diagnosis, Health
Abstract

Human bornavirus encephalitis is a severe and often fatal disease caused by 2 related zoonotic members of the family Bornaviridae, variegated squirrel bornavirus 1 (VSBV-1, species Mammalian 2 orthobornavirus) and [...]

Published
2021
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28. Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999–2019: an epidemiological investigation

Author

Niller, Hans Helmut, Angstwurm, Klemens, Rubbenstroth, Dennis, Schlottau, Kore, Ebinger, Arnt, Giese, Sebastian, Wunderlich, Silke, Banas, Bernhard, Forth, Leonie F, Hoffmann, Donata, Höper, Dirk, Schwemmle, Martin, Tappe, Dennis, Schmidt-Chanasit, Jonas, Nobach, Daniel, Herden, Christiane, Brochhausen, Christoph, Velez-Char, Natalia, Mamilos, Andreas, Utpatel, Kirsten, Evert, Matthias, Zoubaa, Saida, Riemenschneider, Markus J, Ruf, Viktoria, Herms, Jochen, Rieder, Georg, Errath, Mario, Matiasek, Kaspar, Schlegel, Jürgen, Liesche-Starnecker, Friederike, Neumann, Bernhard, Fuchs, Kornelius, Linker, Ralf A, Salzberger, Bernd, Freilinger, Tobias, Gartner, Lisa, Wenzel, Jürgen J, Reischl, Udo, Jilg, Wolfgang, Gessner, André, Jantsch, Jonathan, Beer, Martin, and Schmidt, Barbara

Published
2020
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29. Correction to: Differential neurovirulence of Usutu viruslineages in mice and neuronal cells

Author

Clé, Marion, Constant, Orianne, Barthelemy, Jonathan, Desmetz, Caroline, Martin, Marie France, Lapeyre, Lina, Cadar, Daniel, Savini, Giovanni, Teodori, Liana, Monaco, Federica, Schmidt-Chanasit, Jonas, Saiz, Juan-Carlos, Gonzales, Gaëlle, Lecollinet, Sylvie, Beck, Cécile, Gosselet, Fabien, Van de Perre, Philippe, Foulongne, Vincent, Salinas, Sara, and Simonin, Yannick

Published
2021
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31. Differential neurovirulence of Usutu virus lineages in mice and neuronal cells

Author

Clé, Marion, Constant, Orianne, Barthelemy, Jonathan, Desmetz, Caroline, Martin, Marie France, Lapeyre, Lina, Cadar, Daniel, Savini, Giovanni, Teodori, Liana, Monaco, Federica, Schmidt-Chanasit, Jonas, Saiz, Juan-Carlos, Gonzales, Gaëlle, Lecollinet, Sylvie, Beck, Cécile, Gosselet, Fabien, Van de Perre, Philippe, Foulongne, Vincent, Salinas, Sara, and Simonin, Yannick

Published
2021
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35. Arbovirus researchers unite: expanding genomic surveillance for an urgent global need

Author

Wallau, Gabriel Luz, primary, Abanda, Ngu Njei, additional, Abbud, Adriano, additional, Abdella, Saro, additional, Abera, Adugna, additional, Ahuka-Mundeke, Steve, additional, Falconi-Agapito, Francesca, additional, Alagarasu, Kalichamy, additional, Ariën, Kevin K, additional, Ayres, Constancia Flávia Junqueira, additional, Barzon, Luisa, additional, Bonney, Joseph Humphrey Kofi, additional, Boumbaly, Sanaba, additional, Buchy, Philippe, additional, Cao-Lormeau, Van-Mai, additional, Chem, Yu Kie, additional, Cardenas, Paul A, additional, Castillo, Andres E, additional, Delfraro, Adriana, additional, Devine, Gregor, additional, Duong, Veasna, additional, Dupont-Rouzeyrol, Myrielle, additional, Fadeev, Artem V, additional, Fajardo, Alvaro, additional, Diaz, Luis Adrián, additional, Gómez, Lara Ferrero, additional, Gudo, Eduardo Samo, additional, Gutierrez-Bugallo, Gladys, additional, Hapuarachchi, Hapuarachchige Chanditha, additional, Heraud, Jean-Michel, additional, Hibberd, Martin L, additional, Inlamea, Osvaldo Frederico, additional, Jasmin, Nik, additional, Kydyshov, Kalysbek, additional, Kelly, Maria Ezekiely, additional, Khan, Salim, additional, Komissarov, Andrey B, additional, Leaungwutiwong, Pornsawan, additional, Leguia, Mariana, additional, Lustig, Yaniv, additional, Maciel-de-Freitas, Rafael, additional, Malavige, Gathsaurie Neelika, additional, Martinez, Alexander A, additional, Mendoza, Maria L, additional, Mo, Luong T, additional, Moreno, Brechla, additional, Mwasi, Lydia, additional, Naveca, Felipe Gomes, additional, NG, Lee Ching, additional, Njouom, Richard, additional, Nogueira, Mauricio Lacerda, additional, Ntoumi, Francine, additional, Nzoyikorera, Nehemie, additional, Parra, Barbara A, additional, Pichardo, Mauricio Vázquez, additional, Privaldos, Kristine Joy Ragual, additional, Rivero, Ricardo, additional, Rojas, Alejandra María, additional, Salvato, Richard Steiner, additional, Sasmono, R Tedjo, additional, Schmidt-Chanasit, Jonas, additional, Simon-Loriere, Etienne, additional, Sy, Ava Kristy Dy, additional, Talledo-Albujar, Michael, additional, Tizhe, Daniel Thakuma, additional, Toloshovich, Usenbaev Nurbolot, additional, Tran, Vi Thuy, additional, Troupin, Cécile, additional, Kayiwa, John Timothy, additional, van den Hurk, Andrew, additional, Vasilakis, Nikolaos, additional, Weldemariam, Atsbeha Gebreegziabxier, additional, Yacoub, Sophie, additional, Zaini, Zainun, additional, and Wallau, Gabriel Luz, additional

Published
2023
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36. Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011-2013

Author

Tappe, Dennis, Schmidt-Chanasit, Jonas, Rauch, Jessica, Allartz, Petra, and Herden, Christiane

Subjects
Tumor proteins, B cells, Lactates, Immune response, EDTA, Encephalitis, Brain damage, RNA, T cells, Antigens, Macrophages, Infection, Health
Abstract

Variegated squirrel bornavirus (VSBV-1; family Bornaviridae, species Mammalian 2 orthobornavirus) is a new zoonotic virus that causes severe and eventually fatal encephalitis in humans. VSBV-1 was discovered retrospectively in 2015 [...]

Published
2019
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37. Dengue Virus IgM Serotyping by ELISA with Recombinant Mutant Envelope Proteins

Author

Rockstroh, Alexandra, Barzon, Luisa, Kumbukgolla, Widuranga, Su, Hoang Xuan, Lizarazo, Erley, Vincenti-Gonzalez, Maria Fernanda, Tami, Adriana, Ornelas, Alice M.M., Aguiar, Renato Santana, Cadar, Daniel, Schmidt-Chanasit, Jonas, and Ulbert, Sebastian

Subjects
Patient care -- Analysis -- Health aspects, Disease susceptibility -- Analysis -- Health aspects, Infection -- Analysis -- Health aspects, Dengue virus -- Analysis -- Health aspects, Enzyme-linked immunosorbent assay -- Analysis -- Health aspects, Medical research -- Analysis -- Health aspects, Travelers, Shock, Hemorrhagic fevers, Health
Abstract

Dengue virus (DENV) is an arthropodborne flavivirus that is endemic in tropical and subtropical regions, causing hundreds of millions of infections annually (1). It is subdivided into 4 serotypes, DENV-1-4. [...]

Published
2019
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38. Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood

Author

Stanelle-Bertram, Stephanie, Walendy-Gnirß, Kerstin, Speiseder, Thomas, Thiele, Swantje, Asante, Ivy Asantewaa, Dreier, Carola, Kouassi, Nancy Mounogou, Preuß, Annette, Pilnitz-Stolze, Gundula, Müller, Ursula, Thanisch, Stefanie, Richter, Melanie, Scharrenberg, Robin, Kraus, Vanessa, Dörk, Ronja, Schau, Lynn, Herder, Vanessa, Gerhauser, Ingo, Pfankuche, Vanessa Maria, Käufer, Christopher, Waltl, Inken, Moraes, Thais, Sellau, Julie, Hoenow, Stefan, Schmidt-Chanasit, Jonas, Jansen, Stephanie, Schattling, Benjamin, Ittrich, Harald, Bartsch, Udo, Renné, Thomas, Bartenschlager, Ralf, Arck, Petra, Cadar, Daniel, Friese, Manuel A., Vapalahti, Olli, Lotter, Hanna, Benites, Sany, Rolling, Lane, Gabriel, Martin, Baumgärtner, Wolfgang, Morellini, Fabio, Hölter, Sabine M., Amarie, Oana, Fuchs, Helmut, Hrabe de Angelis, Martin, Löscher, Wolfgang, Calderon de Anda, Froylan, and Gabriel, Gülsah

Published
2018
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41. Saison stechmückenübertragener Krankheitserreger beginnt

Author

Frank, Christina, Offergeld, Ruth, Lachmann, Raskit, Stark, Klaus, and Schmidt-Chanasit, Jonas

Subjects
Mückenübertragungen, Chikungunya-Virus, saisonale Krankheitserreger, Enzephalitis, ddc:610, West-Nil-Virus, 610 Medizin und Gesundheit
Abstract

Wie schon in den Vorjahren jeweils im Mai und Juni wird auch dieses Jahr im Epidemiologischen Bulletin 22/2023 auf die beginnende Saison stechmückenübertragener Krankheitserreger hingewiesen. Seit mindestens 2018 zirkuliert in einem Endemiegebiet in Ostdeutschland saisonal das von heimischen (Culex-)Stechmücken übertragene West-Nil-Virus (WNV) zwischen Stechmücken und Vögeln, wobei Menschen und Pferde gelegentlich als Fehlwirte infiziert werden. Im Jahr 2022 wurden in Deutschland 13 autochthone Fälle von WNV-Infektionen übermittelt, die die deutsche Referenzdefinition erfüllten, sowie vier asymptomatische autochthone Infektionen. In Deutschland breitet sich außerdem die Asiatische Tigermücke (Ae. albopictus) immer weiter aus. Sie kann grundsätzlich exotische saisonale Krankheitserreger wie das Chikungunya-, Dengue- oder Zika-Virus auf Menschen übertragen, wenn sie diese Viren zuvor von infizierten Reiserückkehrenden aus Endemiegebieten aufgenommen hat. Dies ist bislang in Deutschland nicht beobachtet worden, mit möglichen autochthonen menschlichen Chikungunya-Virus-Infektionen ist im Sommer jedoch zu rechnen und aufgrund des Klimawandels dürfte auch die Wahrscheinlichkeit von autochthonen Dengue-Virus-Infektionen eher zunehmen.

Published
2023

43. Empfehlungen der Ständigen Impfkommission (STIKO) und der Deutschen Gesellschaft für Tropenmedizin, Reisemedizin und Globale Gesundheit e.V. (DTG) zu Reiseimpfungen

Author

Kling, Kerstin, Külper-Schiek, Wiebe, Rothe, Camilla, Alberer, Martin, Boecken, Gerhard, Bogdan, Christian, Feldt, Torsten, Köhler, Carsten, Ledig, Thomas, Löscher, Thomas, Meerpohl, Jörg, Mertens, Thomas, Ramharter, Michael, Rieke, Burkhard, Röbl-Mathieu, Marianne, Rosenbusch, Deike, Schmidt-Chanasit, Jonas, Wichmann, Ole, Wiedermann, Ursula, Zepp, Fred, and Burchard, Gerd

Subjects
Reiseimpfungen, Schutzimpfungen, STIKO, Impfempfehlung, ddc:610, Prävention, 610 Medizin und Gesundheit
Abstract

Die STIKO empfiehlt Reiseimpfungen zum individuellen Schutz Reisender mit einem Expositionsrisiko gegenüber bestimmten impfpräventablen Erkrankungen und um den Import von Infektionserregern in das bereiste Land oder bei Rückreise nach Deutschland zu verhindern. Die im Epidemiologischen Bulletin 14/2023 veröffentlichten Empfehlungen zu Reiseimpfungen wurden von der STIKO-AG Reiseimpfungen in Zusammenarbeit mit externen Expertinnen und Experten erarbeitet. Neuerungen sind dabei u. a. die aktualisierte Epidemiologie bei Cholera, Hepatitis A, Hepatitis B, Meningokokken und Typhus sowie eine umfassende Literatur-Aktualisierung.

Published
2023

45. Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013

Author

Tappe, Dennis, Schlottau, Kore, Cadar, Daniel, Hoffmann, Bernd, Balke, Lorenz, Bewig, Burkhard, Hoffmann, Donata, Eisermann, Philip, Fickenscher, Helmut, Krumbholz, Andi, Laufs, Helmut, Huhndorf, Monika, Rosenthal, Maria, Schulz-Schaeffer, Walter, Ismer, Gabriele, Hotop, Sven-Kevin, Bronstrup, Mark, Ott, Anthonina, Schmidt-Chanasit, Jonas, and Beer, Martin

Subjects
Zoos -- Analysis, Autoimmunity -- Analysis, Immunohistochemistry -- Analysis, Phylogeny -- Analysis, Antibodies -- Analysis, Antigenic determinants -- Analysis, Encephalitis -- Analysis, Health
Abstract

Limbic encephalitis, a term coined in 1960 as a clinical/ anatomic description (1), is a rare regional inflammation of the brain involving mainly the limbic system but also other anatomic [...]

Published
2018
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46. Vector Competence of Northern European Culex pipiens Biotype pipiens and Culex torrentium to West Nile Virus and Sindbis Virus

Author

Jansen, Stephanie, primary, Heitmann, Anna, additional, Uusitalo, Ruut, additional, Korhonen, Essi M., additional, Lühken, Renke, additional, Kliemke, Konstantin, additional, Lange, Unchana, additional, Helms, Michelle, additional, Kirjalainen, Lauri, additional, Nykänen, Roope, additional, Gregow, Hilppa, additional, Pirinen, Pentti, additional, Rossini, Giada, additional, Vapalahti, Olli, additional, Schmidt-Chanasit, Jonas, additional, and Huhtamo, Eili, additional

Published
2023
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