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197 results on '"Schmidt, Sandy"'

1. Automatic Disentanglement of Motion in Fetal Low Field MRI Scans

Author

Kitzberger, Michael, Silva, Sara Neves, Verdera, Jordina Aviles, Rojas, Diego Fajardo, Uus, Alena, Schulz-Heise, Susanne, Schmidt, Sandy, Schneider, Michael, Story, Lisa, Uder, Michael, Rutherford, Mary, Hutter, Jana, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Link-Sourani, Daphna, editor, Abaci Turk, Esra, editor, Macgowan, Christopher, editor, Hutter, Jana, editor, Melbourne, Andrew, editor, and Licandro, Roxane, editor

Published
2025
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5. Non-invasive optoacoustic imaging of glycogen-storage and muscle degeneration in late-onset Pompe disease.

Author

Tan, Lina, Zschüntzsch, Jana, Meyer, Stefanie, Stobbe, Alica, Bruex, Hannah, Regensburger, Adrian P., Claßen, Merle, Alves, Frauke, Jüngert, Jörg, Rother, Ulrich, Li, Yi, Danko, Vera, Lang, Werner, Türk, Matthias, Schmidt, Sandy, Vorgerd, Matthias, Schlaffke, Lara, Woelfle, Joachim, Hahn, Andreas, and Mensch, Alexander

Subjects
GLYCOGEN storage disease type II, MAGNETIC resonance imaging, PATHOLOGY, ENZYME replacement therapy, MUSCLE weakness
Abstract

Pompe disease (PD) is a rare autosomal recessive glycogen storage disorder that causes proximal muscle weakness and loss of respiratory function. While enzyme replacement therapy (ERT) is the only effective treatment, biomarkers for disease monitoring are scarce. Following ex vivo biomarker validation in phantom studies, we apply multispectral optoacoustic tomography (MSOT), a laser- and ultrasound-based non-invasive imaging approach, in a clinical trial (NCT05083806) to image the biceps muscles of 10 late-onset PD (LOPD) patients and 10 matched healthy controls. MSOT is compared with muscle magnetic resonance imaging (MRI), ultrasound, spirometry, muscle testing and quality of life scores. Next, results are validated in an independent LOPD patient cohort from a second clinical site. Our study demonstrates that MSOT enables imaging of subcellular disease pathology with increases in glycogen/water, collagen and lipid signals, providing higher sensitivity in detecting muscle degeneration than current methods. This translational approach suggests implementation in the complex care of these rare disease patients. Pompe disease (PD) is a rare disorder that leads to progressive muscle weakness if left untreated. Here, the authors use multispectral optoacoustic tomography (MSOT) to map and quantify the composition of affected muscle tissue to determine disease severity and potentially monitor future therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Replicating a Digital Transformation Case

Author

Schmidt, Sandy, Voß, Marius, Wache, Hendrik, Hönigsberg, Sarah, Dinter, Barbara, Spagnoletti, Paolo, Series Editor, De Marco, Marco, Series Editor, Pouloudi, Nancy, Series Editor, Te'eni, Dov, Series Editor, vom Brocke, Jan, Series Editor, Winter, Robert, Series Editor, Baskerville, Richard, Series Editor, Ahlemann, Frederik, editor, Schütte, Reinhard, editor, and Stieglitz, Stefan, editor

Published
2021
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19. Exciting Enzymes: Current State and Future Perspective of Photobiocatalysis

Author

Alphand, Véronique, primary, van Berkel, Willem J. H., additional, Jurkaš, Valentina, additional, Kara, Selin, additional, Kourist, Robert, additional, Kroutil, Wolfgang, additional, Mascia, Francesco, additional, Nowaczyk, Marc M., additional, Paul, Caroline E., additional, Schmidt, Sandy, additional, Spasic, Jelena, additional, Tamagnini, Paula, additional, and Winkler, Christoph K., additional

Published
2023
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22. Pulmonary Dysfunction after Pediatric COVID-19

Author

Heiss, Rafael, primary, Tan, Lina, additional, Schmidt, Sandy, additional, Regensburger, Adrian P., additional, Ewert, Franziska, additional, Mammadova, Dilbar, additional, Buehler, Adrian, additional, Vogel-Claussen, Jens, additional, Voskrebenzev, Andreas, additional, Rauh, Manfred, additional, Rompel, Oliver, additional, Nagel, Armin M., additional, Lévy, Simon, additional, Bickelhaupt, Sebastian, additional, May, Matthias S., additional, Uder, Michael, additional, Metzler, Markus, additional, Trollmann, Regina, additional, Woelfle, Joachim, additional, Wagner, Alexandra L., additional, and Knieling, Ferdinand, additional

Published
2023
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23. Exciting Enzymes : Current State and Future Perspective of Photobiocatalysis

Author

Alphand, Véronique, van Berkel, Willem J.H., Jurkaš, Valentina, Kara, Selin, Kourist, Robert, Kroutil, Wolfgang, Mascia, Francesco, Nowaczyk, Marc M., Paul, Caroline E., Schmidt, Sandy, Spasic, Jelena, Tamagnini, Paula, Winkler, Christoph K., Alphand, Véronique, van Berkel, Willem J.H., Jurkaš, Valentina, Kara, Selin, Kourist, Robert, Kroutil, Wolfgang, Mascia, Francesco, Nowaczyk, Marc M., Paul, Caroline E., Schmidt, Sandy, Spasic, Jelena, Tamagnini, Paula, and Winkler, Christoph K.

Abstract

The recent increase of interest in photocatalysis spread to biocatalysis and triggered a rush for the development of light-dependent enzyme-mediated or enzyme-coupled processes. After several years of intense research on photobiocatalysis, it is time to evaluate the state of the field in a structured manner. In this Perspective, we suggest to group photobiocatalysis into distinct disciplines and provide principal guidelines and standards for the reporting of photobiocatalytic research results as well as advice on performing photobiocatalytic reactions. Overall, we assess that the field contributes to the diversity of biocatalytic reactions while offering the selectivity of enzymes to photocatalysis. We foresee that the ongoing excitement for light-dependent enzymatic processes will lead to the discovery of novel photobiocatalytic mechanisms to complement biocatalysis with new bond-forming reactions and will provide additional innovative strategies to utilize light as a possible benign energy source.

Published
2023

33. MEMBERS' MEMORABLE BIRDING MOMENTS.

Author

Doherty, Jane, Fincham, John, Fincham, Jo, Blackshaw, Jessie, Lunau-Johns, Zoë, Hodgson, Andrew, Hodgson, Heather, Pringle, Graham, Barnes, Gillian, Tripp, Mel, van Oudtshoorn, Pieter, Hoffmann, Klaus, Zuyl, Angela, Beeton, Priscilla, and Schmidt, Sandy

Subjects
BIRD watching, WATER birds, RARE birds, FLOWERING of plants, RAINBOWS, ORNAMENTAL plants, HUMMINGBIRDS
Published
2023

34. Persisting pulmonary dysfunction in pediatric post-acute Covid-19

Author

Heiss, Rafael, primary, Wagner, Alexandra, additional, Tan, Lina, additional, Schmidt, Sandy, additional, Regensburger, Adrian P., additional, Ewert, Franziska, additional, Mammadova, Dilbar, additional, Buehler, Adrian, additional, Vogel-Claussen, Jens, additional, Voskrebenzev, Andreas, additional, Rauh, Manfred, additional, Rompel, Oliver, additional, Nagel, Armin M., additional, Lévy, Simon, additional, Bickelhaupt, Sebastian, additional, May, Matthias S., additional, Uder, Michael, additional, Metzler, Markus, additional, Trollmann, Regina, additional, Woelfle, Joachim, additional, and Knieling, Ferdinand, additional

Published
2022
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35. Photocatalysis to promote cell-free biocatalytic reactions

Author

Höfler, G.T., Hollmann, F., Paul, C.E., Rauch, M.C.R., van Schie, M.M.C.H., Willot, S.J., Kourist, Robert, and Schmidt, Sandy

Subjects
nicotinamide cofactor, redox reactions, flavin, photobiocatalysis, oxidoreductases
Abstract

Cofactors assist enzymes to catalyze reactions and are indispensable and ubiquitous in nature, playing a central role in metabolic pathways. In biocatalysis, common redox cofactors such as nicotinamide, flavin and heme can be activated by light or synthetized to vary redox potentials, leading to different types of reactions for the formation of interesting chiral products, unattainable through classical chemical methods. This chapter will focus on light-driven cell-free biocatalytic reactions activated via their redox cofactors.

Published
2021

37. Multi-Enzymatic Cascades In Vitro

Author

Kara, Selin, Rudroff, Florian, Schmidt, Sandy, Schallmey, Anett, Kourist, Robert, Kara, Selin, Rudroff, Florian, Schmidt, Sandy, Schallmey, Anett, and Kourist, Robert

Abstract

The combination of enzymatic reactions in a simultaneous or sequential fashion by designing artificial synthetic cascades allows for the synthesis of complex compounds from simple precursors. Such multi-catalytic cascade reactions not only bear a great potential to minimize downstream processing steps but can also lead to a drastic reduction of the produced waste. With the growing toolbox of biocatalysts, alternative routes employing enzymatic transformations towards manifold and diverse target molecules become accessible. In vitro cascade reactions open up new possibilities for efficient regeneration of the required cofactors such as nicotinamide cofactors or nucleoside triphosphates. They are represented by a vast array of two-enzyme cascades that have been designed by coupling the activity of a cofactor regenerating enzyme to the product generating enzyme. However, the implementation of cascade reactions requires careful consideration, particularly with respect to whether the pathway is constructed concurrently or sequentially. In this regard, this chapter describes how biocatalytic cascades are classified, and how such cascade reactions can be employed in order to solve synthetic problems. Recent developments in the area of dynamic kinetic resolution or cofactor regeneration and showcases are presented. We also highlight the factors that influence the design and implementation of purely enzymatic cascades in one-pot or multi-step pathways in an industrial setting.

Published
2021

38. Baeyer-Villiger monooxygenases

Author

Schmidt, Sandy, Bornscheuer, Uwe T., Chaiyen, Pimchai, Tamanoi, Fuyuhiko, Chemical and Pharmaceutical Biology, and Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

Subjects
biology, 010405 organic chemistry, Chemistry, Commodity chemicals, Protein engineering, Monooxygenase, Enzymatic synthesis, 010402 general chemistry, 01 natural sciences, Baeyer-Villiger, 0104 chemical sciences, Cascades, Biocatalysis, Cyclohexanone monooxygenase, Oxidation, biology.protein, Biochemical engineering
Abstract

Biocatalytic processes are well established for the synthesis of high-value fine chemicals, especially for chiral pharmaceutical intermediates, by using natural or engineered enzymes. In contrast, examples for the enzymatic synthesis of bulk chemicals are still rare. Especially for the synthesis of polymer precursors such as ɛ-caprolactone, that is still produced under harsh conditions by using peracetic acid, Baeyer-Villiger monooxygenases (BVMOs) represent promising alternative catalysts that can perform the reaction under mild conditions. However, industrial production of this bulk chemical using a biocatalyst such as a BVMO has not been achieved yet due to a number of reasons. In this book chapter, we are emphasizing the versatility of BVMOs and their catalyzed reactions, and address several examples where protein engineering was applied in order to overcome several limitations associated to the use of BVMOs. Finally, we highlight several examples of BVMO applications, either in single enzyme transformations, or BVMOs involved in cascade reactions. By mainly focusing on recent developments and achievements in the field, we outline different concepts that were developed in order to pave the way for an industrial application of BVMOs.

Published
2020

42. Photoexcited Enzymes for Asymmetric Csp3−Csp3 Cross‐Electrophile Couplings.

Author

Schmidt, Sandy

Subjects
*ELECTROPHILES, *ENZYMES, *BIOCATALYSIS, *ORGANIC synthesis, *CATALYST synthesis, *CHEMISTS, *SELF-efficacy
Abstract

Enzymes have several advantages over conventional catalysts for organic synthesis. Over the last two decades, much effort has been made to further extend the scope of biocatalytic reactions available to synthetic chemists, particularly by expanding the repertoire of enzymes for abiological transformations. In this regard, exciting new developments in the area of photobiocatalysis enable now the introduction of non‐natural reactivity in enzymes to solve long‐standing synthetic challenges. A recently described example from the Hyster group demonstrates in an unprecedented way how the combination of photochemistry with enzyme catalysis empowers the catalytic asymmetric construction of Csp3−Csp3 bonds with high chemo‐ and enantioselectivity. [ABSTRACT FROM AUTHOR]

Published
2022
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44. ACS Catalysis / Photo-Biocatalysis: Biotransformations in the Presence of Light

Author

Schmermund, Luca, Jurkaš, Valentin, Özgen, Feyza F., Barone, Giovanni D., Büchsenschütz, Hanna C., Winkler, Christoph K., Schmidt, Sandy, Kourist, Robert, and Kroutil, Wolfgang

Abstract

Light has received increased attention for various chemical reactions but also in combination with biocatalytic reactions. Because currently only a few enzymatic reactions are known, which per se require light, most transformations involving light and a biocatalyst exploit light either for providing the cosubstrate or cofactor in an appropriate redox state for the biotransformation. In selected cases, a promiscuous activity of known enzymes in the presence of light could be induced. In other approaches, light-induced chemical reactions have been combined with a biocatalytic step, or light-induced biocatalytic reactions were combined with chemical reactions in a linear cascade. Finally, enzymes with a light switchable moiety have been investigated to turn off/on or tune the actual reaction. This Review gives an overview of the various approaches for using light in biocatalysis. Version of record

Published
2019

45. Photobiocatalytic alcohol oxidation using LED light sources

Author

Rauch, Marine, Schmidt, Sandy, Arends, Isabel, Oppelt, Kerstin, Kara, Selin, Hollmann, Frank, Rauch, Marine, Schmidt, Sandy, Arends, Isabel, Oppelt, Kerstin, Kara, Selin, and Hollmann, Frank

Abstract

The photocatalytic oxidation of NADH using a flavin photocatalyst and a simple blue LED light source is reported. This in situ NAD+ regeneration system can be used to promote biocatalytic, enantioselective oxidation reactions. Compared to the traditional use of white light bulbs this method enables very significant reductions in energy consumption and CO2 emission.

Published
2019

48. Photo-Biocatalysis: Biotransformations in the Presence of Light

Author

Schmermund, Luca, primary, Jurkaš, Valentina, additional, Özgen, F. Feyza, additional, Barone, Giovanni D., additional, Büchsenschütz, Hanna C., additional, Winkler, Christoph K., additional, Schmidt, Sandy, additional, Kourist, Robert, additional, and Kroutil, Wolfgang, additional

Published
2019
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