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2. The co-evolution of the genome and epigenome in colorectal cancer

Author

Heide, Timon, Househam, Jacob, Cresswell, George D., Spiteri, Inmaculada, Lynn, Claire, Mossner, Maximilian, Kimberley, Chris, Fernandez-Mateos, Javier, Chen, Bingjie, Zapata, Luis, James, Chela, Barozzi, Iros, Chkhaidze, Ketevan, Nichol, Daniel, Gunasri, Vinaya, Berner, Alison, Schmidt, Melissa, Lakatos, Eszter, Baker, Ann-Marie, Costa, Helena, Mitchinson, Miriam, Piazza, Rocco, Jansen, Marnix, Caravagna, Giulio, Ramazzotti, Daniele, Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Graham, Trevor A., and Sottoriva, Andrea

Published
2022
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3. Phenotypic plasticity and genetic control in colorectal cancer evolution

Author

Househam, Jacob, Heide, Timon, Cresswell, George D., Spiteri, Inmaculada, Kimberley, Chris, Zapata, Luis, Lynn, Claire, James, Chela, Mossner, Maximilian, Fernandez-Mateos, Javier, Vinceti, Alessandro, Baker, Ann-Marie, Gabbutt, Calum, Berner, Alison, Schmidt, Melissa, Chen, Bingjie, Lakatos, Eszter, Gunasri, Vinaya, Nichol, Daniel, Costa, Helena, Mitchinson, Miriam, Ramazzotti, Daniele, Werner, Benjamin, Iorio, Francesco, Jansen, Marnix, Caravagna, Giulio, Barnes, Chris P., Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Sottoriva, Andrea, and Graham, Trevor A.

Published
2022
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6. Respect - A multicenter retrospective study on preoperative chemotherapy in locally advanced and borderline resectable pancreatic cancer

Author

Schmid, Daniel, D'Haese, Jan G., Werner, Jens, Boeck, Stefan, Kruger, Stephan, Haas, Michael, Roeder, Falk, Friess, Helmut, Chiaro, Marco del, Löhr, Matthias, Tamburrino, Domenico, Falconi, Massimo, Masini, Gaia, Maisonneuve, Patrick, Malleo, Giuseppe, Salvia, Roberto, Bassi, Claudio, Charnley, Richard, Algül, Hana, Schmidt, Melissa, Lange, Sebastian, Michl, Patrick, Weniger, Maximilian, Moir, John, Damm, Marko, Maggino, Laura, Kordes, Maximilian, Rosendahl, Jonas, Ceyhan, Güralp O., and Schorn, Stephan

Published
2020
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10. Data from Epidemiologic Risk Factors in a Comparison of a Barrett Esophagus Registry (BarrettNET) and a Case–Control Population in Germany

Author

Schmidt, Melissa, primary, Ankerst, Donna P., primary, Chen, Yiyao, primary, Wiethaler, Maria, primary, Slotta-Huspenina, Julia, primary, Becker, Karl-Friedrich, primary, Horstmann, Julia, primary, Kohlmayer, Florian, primary, Lehmann, Andreas, primary, Linkohr, Birgit, primary, Strauch, Konstantin, primary, Schmid, Roland M., primary, Quante, Anne S., primary, and Quante, Michael, primary

Published
2023
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11. Supplemental Table 1 from Epidemiologic Risk Factors in a Comparison of a Barrett Esophagus Registry (BarrettNET) and a Case–Control Population in Germany

Author

Schmidt, Melissa, primary, Ankerst, Donna P., primary, Chen, Yiyao, primary, Wiethaler, Maria, primary, Slotta-Huspenina, Julia, primary, Becker, Karl-Friedrich, primary, Horstmann, Julia, primary, Kohlmayer, Florian, primary, Lehmann, Andreas, primary, Linkohr, Birgit, primary, Strauch, Konstantin, primary, Schmid, Roland M., primary, Quante, Anne S., primary, and Quante, Michael, primary

Published
2023
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12. Supplementary Figure Legends from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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13. Supplementary Tables 1-2 from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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14. Supplementary Figures 1-5 from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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15. Data from Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, primary, Liu, Fang, primary, Ull, Anna Theresa, primary, Warta, Rolf, primary, Jungk, Christine, primary, Roesch, Saskia, primary, Mock, Andreas, primary, Sahm, Felix, primary, Schmidt, Melissa, primary, Jungwirth, Gerhard, primary, Zweckberger, Klaus, primary, Lamszus, Katrin, primary, Gousias, Konstaninos, primary, Kessler, Almuth F., primary, Grabe, Niels, primary, Loehr, Mario, primary, Ketter, Ralf, primary, Urbschat, Steffi, primary, Senft, Christian, primary, Westphal, Manfred, primary, Abdollahi, Amir, primary, Debus, Juergen, primary, von Deimling, Andreas, primary, Unterberg, Andreas, primary, Simon, Matthias, primary, and Herold-Mende, Christel C., primary

Published
2023
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16. Staff Snapshots | Melissa Schmidt

Author

Schmidt, Melissa

Subjects
Wisconsin. State Legislature -- Powers and duties, Attorneys -- Interviews, Government
Abstract

May 6, 2022 | State Legislatures News NCSL involvement: Schmidt is a 2020 graduate of the Legislative Staff Management Institute and the 2022 staff vice chair of NCSL's Communications, Financial [...]

Published
2022

18. TERT Promoter Mutations and Risk of Recurrence in Meningioma

Author

Sahm, Felix, Schrimpf, Daniel, Olar, Adriana, Koelsche, Christian, Reuss, David, Bissel, Juliane, Kratz, Annekathrin, Capper, David, Schefzyk, Sebastian, Hielscher, Thomas, Wang, Qianghu, Sulman, Erik P., Adeberg, Sebastian, Koch, Arend, Okuducu, Ali Fuat, Brehmer, Stefanie, Schittenhelm, Jens, Becker, Albert, Brokinkel, Benjamin, Schmidt, Melissa, Ull, Theresa, Gousias, Konstantinos, Kessler, Almuth Friederike, Lamszus, Katrin, Debus, Jürgen, Mawrin, Christian, Kim, Yoo-Jin, Simon, Matthias, Ketter, Ralf, Paulus, Werner, Aldape, Kenneth D., Herold-Mende, Christel, and von Deimling, Andreas

Published
2016
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19. Phenotypic plasticity and genetic control in colorectal cancer evolution

Author

Househam, J, Heide, T, Cresswell, G, Spiteri, I, Kimberley, C, Zapata, L, Lynn, C, James, C, Mossner, M, Fernandez-Mateos, J, Vinceti, A, Baker, A, Gabbutt, C, Berner, A, Schmidt, M, Chen, B, Lakatos, E, Gunasri, V, Nichol, D, Costa, H, Mitchinson, M, Ramazzotti, D, Werner, B, Iorio, F, Jansen, M, Caravagna, G, Barnes, C, Shibata, D, Bridgewater, J, Rodriguez-Justo, M, Magnani, L, Sottoriva, A, Graham, T, Househam, Jacob, Heide, Timon, Cresswell, George D., Spiteri, Inmaculada, Kimberley, Chris, Zapata, Luis, Lynn, Claire, James, Chela, Mossner, Maximilian, Fernandez-Mateos, Javier, Vinceti, Alessandro, Baker, Ann-Marie, Gabbutt, Calum, Berner, Alison, Schmidt, Melissa, Chen, Bingjie, Lakatos, Eszter, Gunasri, Vinaya, Nichol, Daniel, Costa, Helena, Mitchinson, Miriam, Ramazzotti, Daniele, Werner, Benjamin, Iorio, Francesco, Jansen, Marnix, Caravagna, Giulio, Barnes, Chris P., Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Sottoriva, Andrea, Graham, Trevor A., Househam, J, Heide, T, Cresswell, G, Spiteri, I, Kimberley, C, Zapata, L, Lynn, C, James, C, Mossner, M, Fernandez-Mateos, J, Vinceti, A, Baker, A, Gabbutt, C, Berner, A, Schmidt, M, Chen, B, Lakatos, E, Gunasri, V, Nichol, D, Costa, H, Mitchinson, M, Ramazzotti, D, Werner, B, Iorio, F, Jansen, M, Caravagna, G, Barnes, C, Shibata, D, Bridgewater, J, Rodriguez-Justo, M, Magnani, L, Sottoriva, A, Graham, T, Househam, Jacob, Heide, Timon, Cresswell, George D., Spiteri, Inmaculada, Kimberley, Chris, Zapata, Luis, Lynn, Claire, James, Chela, Mossner, Maximilian, Fernandez-Mateos, Javier, Vinceti, Alessandro, Baker, Ann-Marie, Gabbutt, Calum, Berner, Alison, Schmidt, Melissa, Chen, Bingjie, Lakatos, Eszter, Gunasri, Vinaya, Nichol, Daniel, Costa, Helena, Mitchinson, Miriam, Ramazzotti, Daniele, Werner, Benjamin, Iorio, Francesco, Jansen, Marnix, Caravagna, Giulio, Barnes, Chris P., Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Sottoriva, Andrea, and Graham, Trevor A.

Abstract

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity1. The interplay of these biological processes and their respective contributions to tumour evolution remain unknown. Here we show that intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer (CRC). Using spatially resolved paired whole-genome and transcriptome sequencing, we find that the majority of intratumour variation in gene expression is not strongly heritable but rather ‘plastic’. Somatic expression quantitative trait loci analysis identified a number of putative genetic controls of expression by cis-acting coding and non-coding mutations, the majority of which were clonal within a tumour, alongside frequent structural alterations. Consistently, computational inference on the spatial patterning of tumour phylogenies finds that a considerable proportion of CRCs did not show evidence of subclonal selection, with only a subset of putative genetic drivers associated with subclone expansions. Spatial intermixing of clones is common, with some tumours growing exponentially and others only at the periphery. Together, our data suggest that most genetic intratumour variation in CRC has no major phenotypic consequence and that transcriptional plasticity is, instead, widespread within a tumour.

Published
2022

20. The co-evolution of the genome and epigenome in colorectal cancer

Author

Heide, T, Househam, J, Cresswell, G, Spiteri, I, Lynn, C, Mossner, M, Kimberley, C, Fernandez-Mateos, J, Chen, B, Zapata, L, James, C, Barozzi, I, Chkhaidze, K, Nichol, D, Gunasri, V, Berner, A, Schmidt, M, Lakatos, E, Baker, A, Costa, H, Mitchinson, M, Piazza, R, Jansen, M, Caravagna, G, Ramazzotti, D, Shibata, D, Bridgewater, J, Rodriguez-Justo, M, Magnani, L, Graham, T, Sottoriva, A, Heide, Timon, Househam, Jacob, Cresswell, George D., Spiteri, Inmaculada, Lynn, Claire, Mossner, Maximilian, Kimberley, Chris, Fernandez-Mateos, Javier, Chen, Bingjie, Zapata, Luis, James, Chela, Barozzi, Iros, Chkhaidze, Ketevan, Nichol, Daniel, Gunasri, Vinaya, Berner, Alison, Schmidt, Melissa, Lakatos, Eszter, Baker, Ann-Marie, Costa, Helena, Mitchinson, Miriam, Piazza, Rocco, Jansen, Marnix, Caravagna, Giulio, Ramazzotti, Daniele, Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Graham, Trevor A., Sottoriva, Andrea, Heide, T, Househam, J, Cresswell, G, Spiteri, I, Lynn, C, Mossner, M, Kimberley, C, Fernandez-Mateos, J, Chen, B, Zapata, L, James, C, Barozzi, I, Chkhaidze, K, Nichol, D, Gunasri, V, Berner, A, Schmidt, M, Lakatos, E, Baker, A, Costa, H, Mitchinson, M, Piazza, R, Jansen, M, Caravagna, G, Ramazzotti, D, Shibata, D, Bridgewater, J, Rodriguez-Justo, M, Magnani, L, Graham, T, Sottoriva, A, Heide, Timon, Househam, Jacob, Cresswell, George D., Spiteri, Inmaculada, Lynn, Claire, Mossner, Maximilian, Kimberley, Chris, Fernandez-Mateos, Javier, Chen, Bingjie, Zapata, Luis, James, Chela, Barozzi, Iros, Chkhaidze, Ketevan, Nichol, Daniel, Gunasri, Vinaya, Berner, Alison, Schmidt, Melissa, Lakatos, Eszter, Baker, Ann-Marie, Costa, Helena, Mitchinson, Miriam, Piazza, Rocco, Jansen, Marnix, Caravagna, Giulio, Ramazzotti, Daniele, Shibata, Darryl, Bridgewater, John, Rodriguez-Justo, Manuel, Magnani, Luca, Graham, Trevor A., and Sottoriva, Andrea

Abstract

Colorectal malignancies are a leading cause of cancer-related death1and have undergone extensive genomic study2,3. However, DNA mutations alone do not fully explain malignant transformation4–7. Here we investigate the co-evolution of the genome and epigenome of colorectal tumours at single-clone resolution using spatial multi-omic profiling of individual glands. We collected 1,370 samples from 30 primary cancers and 8 concomitant adenomas and generated 1,207 chromatin accessibility profiles, 527 whole genomes and 297 whole transcriptomes. We found positive selection for DNA mutations in chromatin modifier genes and recurrent somatic chromatin accessibility alterations, including in regulatory regions of cancer driver genes that were otherwise devoid of genetic mutations. Genome-wide alterations in accessibility for transcription factor binding involved CTCF, downregulation of interferon and increased accessibility for SOX and HOX transcription factor families, suggesting the involvement of developmental genes during tumourigenesis. Somatic chromatin accessibility alterations were heritable and distinguished adenomas from cancers. Mutational signature analysis showed that the epigenome in turn influences the accumulation of DNA mutations. This study provides a map of genetic and epigenetic tumour heterogeneity, with fundamental implications for understanding colorectal cancer biology.

Published
2022

23. The co-evolution of the genome and epigenome in colorectal cancer

Author

Sottoriva, Andrea, primary, Heide, Timon, additional, Cresswell, George, additional, Spiteri, Inma, additional, Lynn, Claire, additional, Fernandez-Mateos, Javier, additional, Chen, Bingjie, additional, Zapata, Luis, additional, Chkhaidze, Kate, additional, Nichol, Daniel, additional, Caravagna, Giulio, additional, James, Chela, additional, Mossner, Maximilian, additional, Kimberley, Christopher, additional, Househam, Jacob, additional, Berner, Alison, additional, Schmidt, Melissa, additional, Lakatos, Eszter, additional, Baker, Ann-Marie, additional, Graham, Trevor, additional, Barozzi, Iros, additional, Costa, Helena, additional, Mitchinson, Miriam, additional, Jansen, Marnix, additional, Bridgewater, John, additional, Rodriguez-Justo, Manuel, additional, Magnani, Luca, additional, Ramazzotti, Daniele, additional, and Shibata, Darryl, additional

Published
2021
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25. Phenotypic plasticity and genetic control in colorectal cancer evolution

Author

Househam, Jacob, primary, Heide, Timon, additional, Cresswell, George D, additional, Lynn, Claire, additional, Spiteri, Inmaculada, additional, Mossner, Max, additional, Kimberley, Chris, additional, Gabbutt, Calum, additional, Lakatos, Eszter, additional, Fernandez-Mateos, Javier, additional, Chen, Bingjie, additional, Zapata, Luis, additional, James, Chela, additional, Berner, Alison, additional, Schmidt, Melissa, additional, Baker, Ann-Marie, additional, Nichol, Daniel, additional, Costa, Helena, additional, Mitchinson, Miriam, additional, Jansen, Marnix, additional, Caravagna, Giulio, additional, Shibata, Darryl, additional, Bridgewater, John, additional, Rodriguez-Justo, Manuel, additional, Magnani, Luca, additional, Sottoriva, Andrea, additional, and Graham, Trevor A, additional

Published
2021
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26. Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

Author

Heide, Timon, primary, Househam, Jacob, additional, Cresswell, George D, additional, Spiteri, Inmaculada, additional, Lynn, Claire, additional, Kimberley, Chris, additional, Mossner, Max, additional, Zapata, Luis, additional, Gabbutt, Calum, additional, Ramazzotti, Daniele, additional, Chen, Bingjie, additional, Fernandez-Mateos, Javier, additional, James, Chela, additional, Vinceti, Alessandro, additional, Berner, Alison, additional, Schmidt, Melissa, additional, Lakatos, Eszter, additional, Baker, Ann-Marie, additional, Nichol, Daniel, additional, Costa, Helena, additional, Mitchinson, Miriam, additional, Werner, Benjamin, additional, Iorio, Francesco, additional, Jansen, Marnix, additional, Barnes, Christopher, additional, Caravagna, Giulio, additional, Shibata, Darryl, additional, Bridgewater, John, additional, Rodriguez-Justo, Manuel, additional, Magnani, Luca, additional, Graham, Trevor A, additional, and Sottoriva, Andrea, additional

Published
2021
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27. The co-evolution of the genome and epigenome in colorectal cancer

Author

Heide, Timon, primary, Househam, Jacob, additional, Cresswell, George D, additional, Spiteri, Inmaculada, additional, Lynn, Claire, additional, Mossner, Max, additional, Kimberley, Chris, additional, Fernandez-Mateos, Javier, additional, Chen, Bingjie, additional, Zapata, Luis, additional, James, Chela, additional, Barozzi, Iros, additional, Chkhaidze, Ketevan, additional, Nichol, Daniel, additional, Berner, Alison, additional, Schmidt, Melissa, additional, Lakatos, Eszter, additional, Baker, Ann-Marie, additional, Costa, Helena, additional, Mitchinson, Miriam, additional, Jansen, Marnix, additional, Caravagna, Giulio, additional, Ramazzotti, Daniele, additional, Shibata, Darryl, additional, Bridgewater, John, additional, Rodriguez-Justo, Manuel, additional, Magnani, Luca, additional, Graham, Trevor A, additional, and Sottoriva, Andrea, additional

Published
2021
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32. Respect - A multicenter retrospective study on preoperative chemotherapy in locally advanced and borderline resectable pancreatic cancer

Author

Weniger, Maximilian, primary, Moir, John, additional, Damm, Marko, additional, Maggino, Laura, additional, Kordes, Maximilian, additional, Rosendahl, Jonas, additional, Ceyhan, Güralp O., additional, Schorn, Stephan, additional, Schmid, Daniel, additional, D'Haese, Jan G., additional, Werner, Jens, additional, Boeck, Stefan, additional, Kruger, Stephan, additional, Haas, Michael, additional, Roeder, Falk, additional, Friess, Helmut, additional, Chiaro, Marco del, additional, Löhr, Matthias, additional, Tamburrino, Domenico, additional, Falconi, Massimo, additional, Masini, Gaia, additional, Maisonneuve, Patrick, additional, Malleo, Giuseppe, additional, Salvia, Roberto, additional, Bassi, Claudio, additional, Charnley, Richard, additional, Algül, Hana, additional, Schmidt, Melissa, additional, Lange, Sebastian, additional, and Michl, Patrick, additional

Published
2020
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33. Epidemiologic Risk Factors in a Comparison of a Barrett Esophagus Registry (BarrettNET) and a Case–Control Population in Germany

Author

Schmidt, Melissa, primary, Ankerst, Donna P., additional, Chen, Yiyao, additional, Wiethaler, Maria, additional, Slotta-Huspenina, Julia, additional, Becker, Karl-Friedrich, additional, Horstmann, Julia, additional, Kohlmayer, Florian, additional, Lehmann, Andreas, additional, Linkohr, Birgit, additional, Strauch, Konstantin, additional, Schmid, Roland M., additional, Quante, Anne S., additional, and Quante, Michael, additional

Published
2020
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38. Cytotoxic T Cells and their Activation Status are Independent Prognostic Markers in Meningiomas

Author

Rapp, Carmen, primary, Dettling, Steffen, additional, Liu, Fang, additional, Ull, Anna Theresa, additional, Warta, Rolf, additional, Jungk, Christine, additional, Roesch, Saskia, additional, Mock, Andreas, additional, Sahm, Felix, additional, Schmidt, Melissa, additional, Jungwirth, Gerhard, additional, Zweckberger, Klaus, additional, Lamszus, Katrin, additional, Gousias, Konstaninos, additional, Kessler, Almuth F., additional, Grabe, Niels, additional, Loehr, Mario, additional, Ketter, Ralf, additional, Urbschat, Steffi, additional, Senft, Christian, additional, Westphal, Manfred, additional, Abdollahi, Amir, additional, Debus, Juergen, additional, von Deimling, Andreas, additional, Unterberg, Andreas, additional, Simon, Matthias, additional, and Herold-Mende, Christel C., additional

Published
2019
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40. BarrettNET—a prospective registry for risk estimation of patients with Barrett's esophagus to progress to adenocarcinoma

Author

Wiethaler, Maria, primary, Slotta-Huspenina, Julia, additional, Brandtner, Anna, additional, Horstmann, Julia, additional, Wein, Frederik, additional, Baumeister, Theresa, additional, Radani, Nikole, additional, Gerland, Sophie, additional, Anand, Akanksha, additional, Lange, Sebastian, additional, Schmidt, Melissa, additional, Janssen, Klaus-Peter, additional, Conrad, Anja, additional, Johannes, Widya, additional, Strauch, Konstantin, additional, Quante, Anne S, additional, Linkohr, Birgit, additional, Kuhn, Klaus A, additional, Blaser, Rainer, additional, Lehmann, Andreas, additional, Kohlmayer, Florian, additional, Weichert, Wilko, additional, Schmid, Roland M, additional, Becker, Karl-Friedrich, additional, and Quante, Michael, additional

Published
2019
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44. ECM : 70 Most Asked Questions: What You Need to Know

Author

Schmidt, Melissa and Schmidt, Melissa

Subjects
Business enterprises--Data processing--Management, Management information systems, Information resources management--Data processing
Abstract

There has never been a ECM manual like this. ECM 70 Success Secrets is not about the ins and outs of ECM. Instead, it answers the top 70 questions that we are asked and those we come across in forums, our consultancy and education programs. It tells you exactly how to deal with those questions, with tips that have never before been offered in print. This guidebook is also not about ECM best practice and standards details. Instead it introduces everything you want to know to be successful with ECM. A quick look inside of the subjects covered: ECM International Development from Providers, How Taxonomy becomes related with ECM, The Benefits of the ECM Systems, ECM's Goal is to Provide Content Management Security, ECM Systems Define an Easy and Updated Content Management Application, ECM Blog: Where Comprehensive Information on ECM Can be Found, The Competitive ECM Vendors, Making a WWW ECM Possible and Efficient, Delivery of Content Using ECM Publishing Applications, The Start in Business of Every ECM Company, The Benefits of ECM Conference, Benefits of ECM Technology in the Application of Electronic Document Management System, Different Types ECM Distribution Services, Services Offered by ecm-inc.com, Stages when Planning an ECM Project, Reasons why an Enterprise need ECM, Tips Prior to ECM Implementation, What is an ECM Workflow?, Why Do You Need an ECM System, ECM that Works for Engineering Documents, Security: An Essential ECM Feature, ECM Consulting Services, The Entities involved in an Enterprise Content Management or ECM, Which ECM Strategy to Utilize?, Two Pillars of the FileNet ECM Solution, A More Powerful ECM Architecture for Enhanced Content Management, New ECM Technologies: Unifying the Data Needs of Companies, ECM: The solution to Content Management Problems, The ECM Market will Continue to Move, Why Companies Buy ECM, ECM: The Modern Solutions Provider, How to Drive Down ECM Cost, The Application of the Sharepoint software on ECM, Purpose of Every ECM Service, The Growing ECM Market Share: Still a Highly Competitive Area, All About The Importance of ECM, Understanding ECM and Document Imaging, The Content within the ECM, The ECM Post Review, ECM Service Providers Take Away Your Worries, Getting to know some of the major ECM vendors, Some ECM Products Available in the Market, Understanding the Magic Quadrant for ECM, The Hummingbird Ltd venturing into ECM, ECM Printing across the Organization, Quick Publishing Solutions from ECM Scanner, ECM: More than Just a Technology, ECM Training Services: Feed Your Mind, and much more...

Published
2013

47. Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade

Author

Schmidt, Melissa, primary, Mock, Andreas, additional, Jungk, Christine, additional, Sahm, Felix, additional, Ull, Anna Theresa, additional, Warta, Rolf, additional, Lamszus, Katrin, additional, Gousias, Konstantinos, additional, Ketter, Ralf, additional, Roesch, Saskia, additional, Rapp, Carmen, additional, Schefzyk, Sebastian, additional, Urbschat, Steffi, additional, Lahrmann, Bernd, additional, Kessler, Almuth F., additional, Löhr, Mario, additional, Senft, Christian, additional, Grabe, Niels, additional, Reuss, David, additional, Beckhove, Philipp, additional, Westphal, Manfred, additional, von Deimling, Andreas, additional, Unterberg, Andreas, additional, Simon, Matthias, additional, and Herold-Mende, Christel, additional

Published
2016
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48. TERT Promoter Mutations and Risk of Recurrence in Meningioma

Author

Sahm, Felix, primary, Schrimpf, Daniel, additional, Olar, Adriana, additional, Koelsche, Christian, additional, Reuss, David, additional, Bissel, Juliane, additional, Kratz, Annekathrin, additional, Capper, David, additional, Schefzyk, Sebastian, additional, Hielscher, Thomas, additional, Wang, Qianghu, additional, Sulman, Erik P., additional, Adeberg, Sebastian, additional, Koch, Arend, additional, Okuducu, Ali Fuat, additional, Brehmer, Stefanie, additional, Schittenhelm, Jens, additional, Becker, Albert, additional, Brokinkel, Benjamin, additional, Schmidt, Melissa, additional, Ull, Theresa, additional, Gousias, Konstantinos, additional, Friederike, Almuth, additional, Lamszus, Kessler, Katrin, additional, Debus, Jürgen, additional, Mawrin, Christian, additional, Kim, Yoo-Jin, additional, Simon, Matthias, additional, Ketter, Ralf, additional, Paulus, Werner, additional, Aldape, Kenneth D., additional, Herold-Mende, Christel, additional, and von Deimling, Andreas, additional

Published
2015
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49. Wisconsin brewer's permits as affected by 2011 Wisconsin Act 32

Author

Schmidt, Melissa. and Schmidt, Melissa.

Subjects
Alcohol Law and legislation Wisconsin., License system Wisconsin., Alcoholic beverage industry Wisconsin., Licences de débit de boissons Wisconsin., Boissons alcoolisées Industrie Wisconsin., Alcohol Law and legislation., Alcoholic beverage industry., License system., Wisconsin.
Published
2011

50. Wisconsin's tax incremental financing laws

Author

Schmidt, Melissa. and Schmidt, Melissa.

Subjects
Tax increment financing Law and legislation Wisconsin., Urban renewal Finance. Wisconsin, City planning and redevelopment law Wisconsin., Rénovation urbaine Finances. Wisconsin, City planning and redevelopment law., Tax increment financing Law and legislation., Urban renewal Finance., Wisconsin.
Published
2010

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