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4. Traduction et republication de : « Événements thromboemboliques artériels liés au cancer »

Author

Benhamou, Ygal, Benmaziane, Asmahane, Bertoletti, Laurent, Bichon, Virginie, Bozec, Coralie, Cohen, Ariel, Couturaud, Francis, Debourdeau, Philippe, Dielenseger, Pascale, Douriez, Éric, Élias, Antoine, Espitia, Olivier, Frère, Corinne, Gaboreau, Yoann, Gendron, Pascale, Girard, Philippe, Hanon, Olivier, Idbaih, Ahmed, Laporte, Silvy, Mahé, Isabelle, Mayeur, Didier, Mismetti, Patrick, Moustafa, Farès, Pernod, Gilles, Roy, Pierre-Marie, Rouge Bugat, Marie-Ève, Sanchez, Olivier, Schmidt, Jeannot, Scotté, Florian, and Sevestre, Maie-Antoinette

Published
2024
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9. Inhibition of thrombin-activatable fibrinolysis inhibitor via DS-1040 to accelerate clot lysis in patients with acute pulmonary embolism: a randomized phase 1b study

Author

Huisman, Menno, Tapson, Victor, Grosso, Michael, Segers, Annelise, Ageno, Walter, Brodmann, Marianne, Jimenez, David, Meyer, Guy, Middeldorp, Saskia, Rosovsky, Rachel, Schellong, Sebastian, Verhamme, Peter, Büller, Harry, Bossuyt, Patrick, van Es, Nick, Vanassche, Thomas, Rosovsky, Rachel P., Moustafa, Fares, Büller, Harry R., Patel, Indu, Shi, Minggao, Miyoshi, Naoki, Mani, Venkatesh, Fayad, Zahi, Stephan, Dominique, Schmidt, Jeannot, Grosso, Michael A., Tapson, Victor F., and Huisman, Menno V.

Published
2023
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10. Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data

Author

Stals, Milou A.M., Moumneh, Thomas, Ainle, Fionnuala Ni, Aujesky, Drahomir, van Bemmel, Thomas, Bertoletti, Laurent, Bistervels, Ingrid M., Chauleur, Céline, Couturaud, Francis, van Dooren, Yordi P.A., Elias, Antoine, Faber, Laura M., Le Gall, Catherine, Hofstee, Herman M.A., van der Hulle, Tom, Kruip, Marieke J.H.A., Maignan, Maxime, Mairuhu, Albert T.A., Middeldorp, Saskia, Le Moigne, Emmanuelle, Nijkeuter, Mathilde, van der Pol, Liselotte M., Robert-Ebadi, Helia, Roy, Pierre-Marie, Sanchez, Olivier, Schmidt, Jeannot, van Smeden, Maarten, Tromeur, Cecile, Wolde, Marije ten, Righini, Marc, Le Gal, Grégoire, Huisman, Menno V., and Klok, Frederikus A.

Published
2023
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11. Pulmonary embolism diagnostic strategies in patients with COPD exacerbation: Post-hoc analysis of the PEP trial

Author

Rambaud, Geoffroy, Mai, Vicky, Motreff, Camille, Sanchez, Olivier, Roy, Pierre-Marie, Auffret, Yannick, Le Mao, Raphael, Gagnadoux, Frédéric, Paleiron, Nicolas, Schmidt, Jeannot, Pastre, Jean, Nonent, Michel, Tromeur, Cécile, Salaun, Pierre-Yves, Mismetti, Patrick, Girard, Philippe, Lacut, Karine, Lemarié, Catherine A., Meyer, Guy, Leroyer, Christophe, Le Gal, Grégoire, Bertoletti, Laurent, and Couturaud, Francis

Published
2023
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12. 25 mm Hg versus 35 mm Hg elastic compression stockings to prevent post-thrombotic syndrome after deep vein thrombosis (CELEST): a randomised, double-blind, non-inferiority trial

Author

Bosson, Jean-Luc, Pichot, Olivier, Maufus, Mario, Guenneguez, Hervé, Ouvry, Pierre, Di Maio, Anna, Schmidt, Jeannot, Galanaud, Jean-Philippe, Bura-Rivière, Alessandra, Couturaud, Francis, Danguy Des Déserts, Marc, Grange, Claire, Mismetti, Patrick, Barrellier, Marie-Thérèse, Laneelle, Damien, Terriat, Béatrice, Stansal, Audrey, Martin, Myriam, Quashie, Constant, Bonaldi, Mickaël, Lanoye, Patrick, Ponchaux-Crépin, Francine, Berremili, Toufek, Sevestre-Pietri, Marie-Antoinette, Samy-Modeliar, Santhi, Addala, Azeddine, Toffin, Luc, Rouquet, Bruno, Michot-Casbas, Maïlys, Lacaze, Guillaume, Roy, Pierre-Marie, Durant, Cécile, Baldassini-Esquis, Anne-Laure, Cazanave, Alain, Rouvière, Damien, Skolka, Hélène, Salem, Tewfik, Monsallier, Jean-Michel, Roger, Benoit, Tra, Thien-Quang, Kalolwa, Mutendi, Diard, Antoine, Lambert, Marc, Taiar, Mebarka, Gaudout, Céline, Ancey, Sylvain, Jurus, Christine, Genty-Vermorel, Céline, Becker, François, Jabbour, Violaine, Blaise, Sophie, Comte, Alexa, Guenneguez, Herve, Richaud, Cécile, Rolland, Carole, Sevestre, Marie-Antoinette, and Verrière, François

Published
2022
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13. Risk of neonatal hypothyroidism in newborns from mothers exposed to CTPA during pregnancy: Ancillary data from a prospective outcome study

Author

Righini, Marc, Robert-Ebadi, Helia, Cremonesi, Alessio, Elias, Antoine, Sanchez, Olivier, Le Moigne, Emmanuelle, Schmidt, Jeannot, Le Gall, Catherine, Cornuz, Jacques, Aujesky, Drahomir, Roy, Pierre-Marie, Chauleur, Céline, Rouyer, Frédéric, Poletti, Pierre-Alexandre, Moreau, Caroline, and Le Gal, Grégoire

Published
2022
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14. Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors

Author

Milling, Truman J., Jr, Middeldorp, Saskia, Xu, Lizhen, Koch, Bruce, Demchuk, Andrew, Eikelboom, John W., Verhamme, Peter, Cohen, Alexander T., Beyer-Westendorf, Jan, Michael Gibson, C., Lopez-Sendon, Jose, Crowther, Mark, Shoamanesh, Ashkan, Coppens, Michiel, Schmidt, Jeannot, Albaladejo, Pierre, Connolly, Stuart J., Anand, R., Bastani, A., Clark, C., Concha, M., Cornell, J., Dombrowski, K., Fermann, G., Fulmer, J., Goldstein, J., Kereiakes, D., Milling, T., Pallin, D., Patel, N., Refaai, M., Rehman, M., Schmaier, A., Schwarz, E., Shillinglaw, W., Spohn, M., Takata, T., Venkat, A., Welker, J., Welsby, I., Wilson, J., Van Keer, L., Verschuren, F., Blostein, M., Eikelboom, J., Althaus, K., Berrouschot, J., Braun, G., Doeppner, T., Dziewas, R., Genth-Zotz, S., Greinacher, P., Hamann, F., Hanses, F., Heide, W., Kallmuenzer, B., Kermer, P., Poli, S., Royl, G., Schellong, S., Schnupp, S., Schwarze, J., Spies, C., Thomalla, G., von Mering, M., Weissenborn, K., Wollenweber, F., Gumbinger, C., Jaschinski, U., Maschke, M., Mochmann, H-C., Pfeilschifter, W., Pohlmann, C., Zahn, R., Bouzat, P., Schmidt, J., Vallejo, C., Floccard, B., Coppens, M., van Wissen, S., Arellano-Rodrigo, E., Valles, E., Alikhan, R., Breen, K., Hall, R., Crowther, M., Albaladejo, P., Cohen, A., Demchuk, A.M., Schmidt, J., Wyse, D.G., Garcia, D.A., Prins, M., Nakamya, J., Büller, H.R., Mahaffey, K. W., Alexander, J. H., Cairns, J.A., Hart, R.G., Joyner, C.D., Raskob, G.E., Schulman, S., Veltkamp, R., Meeks, B., Zotova, E., Ahmad, S., Pinto, T., Baker, K., Dykstra, A., Holadyk-Gris, I., Malvaso, A., and Demchuk, A.M.

Published
2023
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17. S100B vs. "GFAP and UCH-L1" assays in the management of mTBI patients.

Author

Oris, Charlotte, Bouillon-Minois, Jean-Baptiste, Kahouadji, Samy, Pereira, Bruno, Dhaiby, Gabriel, Defrance, Valentin Bailly, Durif, Julie, Schmidt, Jeannot, Moustafa, Farès, Bouvier, Damien, and Sapin, Vincent

Subjects
DEUBIQUITINATING enzymes, BRAIN injuries, COMPUTED tomography
Abstract

To compare for the first time the performance of "GFAP and UCH-L1" vs. S100B in a cohort of patients managed for mild traumatic brain injury (mTBI) according to actualized French guidelines. A prospective study was recently carried at the Emergency Department of Clermont-Ferrand University Hospital in France. Patients with mTBI presenting a medium risk of complications were enrolled. Blood S100B and "GFAP and UCHL-1" were sampled and measured according to French guidelines. S100B was measured in patients with samples within 3 h of trauma (Cobas®, Roche Diagnostics), while GFAP and UCHL-1 were measured in all patients (samples <3 h and 3–12 h) using another automated assay (i-STAT® Alinity, Abbott). For sampling <3 h, serum S100B correctly identifies intracranial lesions with a specificity of 25.7 % (95 % CI; 19.5–32.6 %), a sensitivity of 100 % (95 % CI; 66.4–100 %), and a negative predictive value of 100 % (95 % CI; 92.5–100 %). For sampling <12 h, plasma "GFAP and UCH-L1" levels correctly identify intracranial lesions with a specificity of 31.7 % (95 % CI; 25.7–38.2 %), a sensitivity of 100 % (95 % CI; 73.5–100 %), and a negative predictive value of 100 % (95 % CI; 95–100 %). Comparison of specificities (25.7 vs. 31.7 %) did not reveal a statistically significant difference (p=0.16). We highlight the usefulness of measuring plasma "GFAP and UCH-L1" levels to target mTBI patients (sampling within 12 h post-injury) and optimize the reduction of CT scans. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors

Author

Connolly, Stuart J, Milling, Truman J, Eikelboom, John W, Gibson, C Michael, Curnutte, John T, Gold, Alex, Bronson, Michele D, Lu, Genmin, Conley, Pamela B, Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T, Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Goodman, Shelly, Leeds, Janet, Wiens, Brian L, Siegal, Deborah M, Zotova, Elena, Meeks, Brandi, Nakamya, Juliet, Lim, W Ting, and Crowther, Mark

Subjects
Hematology, Clinical Research, Cardiovascular, Acute Disease, Aged, Aged, 80 and over, Cardiovascular Diseases, Enoxaparin, Factor Xa, Factor Xa Inhibitors, Female, Gastrointestinal Hemorrhage, Hemorrhage, Humans, Infusions, Intravenous, Intracranial Hemorrhages, Male, Prospective Studies, Pyrazoles, Pyridones, Recombinant Proteins, Rivaroxaban, Thrombosis, ANNEXA-4 Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundAndexanet alfa (andexanet) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers.MethodsIn this multicenter, prospective, open-label, single-group study, we evaluated 67 patients who had acute major bleeding within 18 hours after the administration of a factor Xa inhibitor. The patients all received a bolus of andexanet followed by a 2-hour infusion of the drug. Patients were evaluated for changes in measures of anti-factor Xa activity and were assessed for clinical hemostatic efficacy during a 12-hour period. All the patients were subsequently followed for 30 days. The efficacy population of 47 patients had a baseline value for anti-factor Xa activity of at least 75 ng per milliliter (or ≥0.5 IU per milliliter for those receiving enoxaparin) and had confirmed bleeding severity at adjudication.ResultsThe mean age of the patients was 77 years; most of the patients had substantial cardiovascular disease. Bleeding was predominantly gastrointestinal or intracranial. The mean (±SD) time from emergency department presentation to the administration of the andexanet bolus was 4.8±1.8 hours. After the bolus administration, the median anti-factor Xa activity decreased by 89% (95% confidence interval [CI], 58 to 94) from baseline among patients receiving rivaroxaban and by 93% (95% CI, 87 to 94) among patients receiving apixaban. These levels remained similar during the 2-hour infusion. Four hours after the end of the infusion, there was a relative decrease from baseline of 39% in the measure of anti-factor Xa activity among patients receiving rivaroxaban and of 30% among those receiving apixaban. Twelve hours after the andexanet infusion, clinical hemostasis was adjudicated as excellent or good in 37 of 47 patients in the efficacy analysis (79%; 95% CI, 64 to 89). Thrombotic events occurred in 12 of 67 patients (18%) during the 30-day follow-up.ConclusionsOn the basis of a descriptive preliminary analysis, an initial bolus and subsequent 2-hour infusion of andexanet substantially reduced anti-factor Xa activity in patients with acute major bleeding associated with factor Xa inhibitors, with effective hemostasis occurring in 79%. (Funded by Portola Pharmaceuticals; ANNEXA-4 ClinicalTrials.gov number, NCT02329327 .).

Published
2016

19. Home treatment for patients with cancer-associated venous thrombo-embolism

Author

Sanchez, Olivier, primary, Roy, Pierre-Marie, additional, Gaboreau, Yoann, additional, Schmidt, Jeannot, additional, Moustafa, Farès, additional, Benmaziane, Asmahane, additional, Elias, Antoine, additional, Espitia, Olivier, additional, Sevestre, Marie-Antoinette, additional, Couturaud, Francis, additional, and Mahé, Isabelle, additional

Published
2023
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23. Outpatient management of cancer-related pulmonary embolism: a post-hoc analysis of the HOME-PE trial

Author

Chaibi, Sérine, primary, Roy, Pierre-Marie, additional, Arnoux, Armelle, additional, Penaloza, Andrea, additional, Hugli, Olivier, additional, Elias, Antoine, additional, Couturaud, Francis, additional, Joly, Luc-Marie, additional, Lopez, Raphaëlle, additional, Faber, Laura M., additional, Planquette, Benjamin, additional, Bokobza, Jérôme, additional, Viglino, Damien, additional, Schmidt, Jeannot, additional, Juchet, Henry, additional, Mahé, Isabelle, additional, Mulder, Frits, additional, Falvo, Nicolas, additional, Montaclair, Karine, additional, Steinier, Charlotte, additional, Hendriks, Stephan V., additional, Benhamou, Ygal, additional, Szwebel, Tali-Anne, additional, Pernod, Gilles, additional, Lapebie, François-Xavier, additional, Javaud, Nicolas, additional, Ghuysen, Alexandre, additional, Sebbane, Mustapha, additional, Jimenez, David, additional, Huisman, Menno V., additional, Klok, Frederikus A., additional, and Sanchez, Olivier, additional

Published
2023
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24. Pulmonary embolism diagnostic strategies in patients with COPD exacerbation: post-hoc analysis of the PEP trial

Author

Mai, Vicky, primary, Rambaud, Geoffroy, additional, Motreff, Camille, additional, Sanchez, Olivier, additional, Roy, Pierre-Marie, additional, Auffret, Yannick, additional, Le Mao, Raphael, additional, Gagnadoux, Frédéric, additional, Paleiron, Nicolas, additional, Schmidt, Jeannot, additional, Pastre, Jean, additional, Nonent, Michel, additional, Tromeur, Cécile, additional, Salaun, Pierre-Yves, additional, Mismetti, Patrick, additional, Girard, Philippe, additional, Lacut, Karine, additional, Lemarié, Catherine, additional, Meyer, Guy, additional, Leroyer, Christophe, additional, Le Gal, Grégoire, additional, Bertoletti, Laurent, additional, and Couturaud, Francis, additional

Published
2023
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25. Thrombin generation in real life bleeding patients on oral anticoagulants reversed (or not) with (activated) prothrombin complex concentrate

Author

Teissandier, Dorian, Moustafa, Farès, Denaives, Amélie, Lebecque, Benjamin, Blondonnet, Raiko, Pereira, Bruno, Monfoulet, Laurent-Emmanuel, Sinegre, Thomas, Schmidt, Jeannot, Lebreton, Aurélien, Pôle Urgences [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Service d’Hématologie Biologique [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Service d'Anésthésie Réanimation [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], and Service de Neurochirurgie [CHU Clermont-Ferrand]

Subjects
Bleeding, Anticoagulant agent, DOACs, Thrombin generation assay, 4F-PCC, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, Hematology
Abstract

International audience; Background: Bleeding during oral anticoagulant therapy is currently codified by expert guidelines. Monitoring of coagulation during bleeding events is challenging. Our study sought to assess thrombin generation assay (TGA) in direct oral anticoagulant-treated patients without bleeding (WB), bleeding without reversal therapy (BR-), and bleeding with reversal therapy (BR+).Methods: We conducted a prospective, monocentric study from June 2015 to June 2018. For all bleeding groups, TGA was evaluated using platelet-poor plasma collected upon arrival at emergency (T0), and 30 min (T1), 6 h (T2) and 24 h (T3) after reversal therapy (if indicated) following activation by tissue factor 5 pM and phospholipids.Results: Overall, 292 patients participated, including 91 BR+, 94 BR-, and 107 WB patients. At T0, vitamin K antagonist reversed (VKA-BR+) patients experienced a significant decrease in TGA parameters (ETP and peak) compared with VKA without bleeding (VKA-WB). Compared with healthy controls, VKA-BR+ patients reversed by four-factor prothrombin complex concentrate (4F-PCC) displayed comparable TGA 's ETP and peak at T1, T2, and T3, whereas direct anti-Xa BR+ patients reversed by 4F-PCC or activated prothrombin complex concentrate (aPCC) reached thrombin generation parameters that exceeded normal range at T2 and T3.Conclusions: In VKA-treated patients reversed by 4F-PCC, TGA parameters were normalized, whereas in rivar-oxaban or apixaban-treated patients reversed by 4F-PCC or aPCC, TGA parameters exceeded normal range. Further studies are needed to compare the efficacy and safety of a different dose of reversal therapy and the impact on coagulation parameters.

Published
2023

26. Pulmonary embolism rule-out criteria (PERC) rule in European patients with low implicit clinical probability (PERCEPIC): a multicentre, prospective, observational study

Author

Penaloza, Andrea, Soulié, Caroline, Moumneh, Thomas, Delmez, Quentin, Ghuysen, Alexandre, El Kouri, Dominique, Brice, Christian, Marjanovic, Nicolas S, Bouget, Jacques, Moustafa, Fares, Trinh-Duc, Albert, Le Gall, Catherine, Imsaad, Lionel, Chrétien, Jean-Marie, Gable, Béatrice, Girard, Philippe, Sanchez, Olivier, Schmidt, Jeannot, Le Gal, Grégoire, Meyer, Guy, Delvau, Nicolas, and Roy, Pierre-Marie

Published
2017
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27. Inhibition of thrombin activatable fibrinolysis inhibitor (TAFI) via DS-1040 to accelerate clot lysis in patients with acute pulmonary embolism: a randomized phase Ib study.

Author

Vanassche, Thomas, primary, Rosovsky, Rachel P., additional, Moustafa, Fares, additional, Bu¨ller, Harry R., additional, Segers, Annelise, additional, Patel, Indu, additional, Shi, Minggao, additional, Miyoshi, Naoki, additional, Mani, Venkatesh, additional, Fayad, Zahi, additional, Stephan, Dominique, additional, Schmidt, Jeannot, additional, Grosso, Michael A., additional, Tapson, Victor F., additional, Verhamme, Peter, additional, and Huisman, Menno V., additional

Published
2023
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28. Simple Aspiration Versus Drainage for Complete Pneumothorax: A Randomized Non-Inferiority Trial

Author

Marx, Tania, primary, Joly, Luc-Marie, additional, Parmentier, Anne-Laure, additional, Pretalli, Jean-Baptiste, additional, Puyraveau, Marc, additional, Meurice, Jean-Claude, additional, Schmidt, Jeannot, additional, Tiffet, Olivier, additional, Ferretti, Gilbert, additional, Lauque, Dominique, additional, Honnart, Didier, additional, Al Freijat, Faraj, additional, Dubart, Alain Eric, additional, Genre Grandpierre, Romain, additional, Viallon, Alain, additional, Perdu, Dominique, additional, Roy, Pierre Marie, additional, El Cadi, Toufiq, additional, Bronet, Nathalie, additional, Duncan, Grégory, additional, Cardot, Gilles, additional, Lestavel, Philippe, additional, Mauny, Frédéric, additional, and Desmettre, Thibaut, additional

Published
2023
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29. A cross-sectional study to assess job strain of emergency healthcare workers by Karasek questionnaire: The SEEK study

Author

Bouillon-Minois, Jean-Baptiste, primary, Trousselard, Marion, additional, Mulliez, Aurélien, additional, Adeyemi, Oluwaseun John, additional, Schmidt, Jeannot, additional, Thivel, David, additional, Ugbolue, Ukadike Chris, additional, Borel, Marjolaine, additional, Moustafa, Farès, additional, Vallet, Guillaume T., additional, Clinchamps, Maëlys, additional, Zak, Marek, additional, Occelli, Céline, additional, and Dutheil, Frédéric, additional

Published
2023
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30. Ionized Magnesium: Interpretation and Interest in Atrial Fibrillation

Author

Bouillon-Minois, Jean-Baptiste, primary, Khaled, Louisa, additional, Vitte, Florence, additional, Miraillet, Ludovic, additional, Eschalier, Romain, additional, Jabaudon, Matthieu, additional, Sapin, Vincent, additional, Derault, Lucas, additional, Kahouadji, Samy, additional, Brailova, Marina, additional, Durif, Julie, additional, Schmidt, Jeannot, additional, Moustafa, Fares, additional, Pereira, Bruno, additional, Futier, Emmanuel, additional, and Bouvier, Damien, additional

Published
2023
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34. sj-docx-1-his-10.1177_11786329231174340 – Supplemental material for The Association Between Age and Admission to an Inappropriate Ward: A Cross-Sectional Survey in France

Author

Naouri, Diane, Panjo, Henri, Moïsi, Laura, El Khoury, Carlos, Serre, Patrice, Schmidt, Jeannot, Yordanov, Youri, and Pelletier-Fleury, Nathalie

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-his-10.1177_11786329231174340 for The Association Between Age and Admission to an Inappropriate Ward: A Cross-Sectional Survey in France by Diane Naouri, Henri Panjo, Laura Moïsi, Carlos El Khoury, Patrice Serre, Jeannot Schmidt, Youri Yordanov and Nathalie Pelletier-Fleury in Health Services Insights

Published
2023
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35. Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism

Author

van der Pol, Liselotte M., Tromeur, Cecile, Bistervels, Ingrid M., Ni Ainle, Fionnuala, van Bemmel, Thomas, Bertoletti, Laurent, Couturaud, Francis, van Dooren, Yordi P. A., Elias, Antoine, Faber, Laura M., Hofstee, Herman M. A., van der Hulle, Tom, Kruip, Marieke J. H. A., Maignan, Maxime, Mairuhu, Albert T. A., Middeldorp, Saskia, Nijkeuter, Mathilde, Roy, Pierre-Marie, Sanchez, Olivier, Schmidt, Jeannot, ten Wolde, Marije, Klok, Frederikus A., and Huisman, Menno V.

Published
2019
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38. 25 mm Hg versus 35 mm Hg elastic compression stockings to prevent post-thrombotic syndrome after deep vein thrombosis (CELEST): a randomised, double-blind, non-inferiority trial

Author

Galanaud, Jean-Philippe, primary, Genty-Vermorel, Céline, additional, Barrellier, Marie-Thérèse, additional, Becker, François, additional, Jabbour, Violaine, additional, Blaise, Sophie, additional, Bura-Rivière, Alessandra, additional, Comte, Alexa, additional, Grange, Claire, additional, Guenneguez, Herve, additional, Maufus, Mario, additional, Ouvry, Pierre, additional, Richaud, Cécile, additional, Rolland, Carole, additional, Schmidt, Jeannot, additional, Sevestre, Marie-Antoinette, additional, Verrière, François, additional, Bosson, Jean-Luc, additional, Pichot, Olivier, additional, Guenneguez, Hervé, additional, Di Maio, Anna, additional, Galanaud, Jean-Philippe, additional, Couturaud, Francis, additional, Danguy Des Déserts, Marc, additional, Mismetti, Patrick, additional, Laneelle, Damien, additional, Terriat, Béatrice, additional, Stansal, Audrey, additional, Martin, Myriam, additional, Quashie, Constant, additional, Bonaldi, Mickaël, additional, Lanoye, Patrick, additional, Ponchaux-Crépin, Francine, additional, Berremili, Toufek, additional, Sevestre-Pietri, Marie-Antoinette, additional, Samy-Modeliar, Santhi, additional, Addala, Azeddine, additional, Toffin, Luc, additional, Rouquet, Bruno, additional, Michot-Casbas, Maïlys, additional, Lacaze, Guillaume, additional, Roy, Pierre-Marie, additional, Durant, Cécile, additional, Baldassini-Esquis, Anne-Laure, additional, Cazanave, Alain, additional, Rouvière, Damien, additional, Skolka, Hélène, additional, Salem, Tewfik, additional, Monsallier, Jean-Michel, additional, Roger, Benoit, additional, Tra, Thien-Quang, additional, Kalolwa, Mutendi, additional, Diard, Antoine, additional, Lambert, Marc, additional, Taiar, Mebarka, additional, Gaudout, Céline, additional, Ancey, Sylvain, additional, and Jurus, Christine, additional

Published
2022
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39. Non-invasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data

Author

Stals, Milou A.M., primary, Moumneh, Thomas, additional, Ainle, Fionnuala Ni, additional, Aujesky, Drahomir, additional, van Bemmel, Thomas, additional, Bertoletti, Laurent, additional, Bistervels, Ingrid M., additional, Chauleur, Céline, additional, Couturaud, Francis, additional, van Dooren, Yordi P.A., additional, Elias, Antoine, additional, Faber, Laura M., additional, Le Gall, Catherine, additional, Hofstee, Herman M.A., additional, van der Hulle, Tom, additional, Kruip, Marieke J.H.A., additional, Maignan, Maxime, additional, Mairuhu, Albert T.A., additional, Middeldorp, Saskia, additional, Le Moigne, Emmanuelle, additional, Nijkeuter, Mathilde, additional, van der Pol, Liselotte M., additional, Robert-Ebadi, Helia, additional, Roy, Pierre-Marie, additional, Sanchez, Olivier, additional, Schmidt, Jeannot, additional, van Smeden, Maarten, additional, Tromeur, Cecile, additional, ten Wolde, Marije, additional, Righini, Marc, additional, Le Gal, Grégoire, additional, Huisman, Menno V., additional, and Klok, Frederikus A., additional

Published
2022
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40. The Impact of Job-Demand-Control-Support on Leptin and Ghrelin as Biomarkers of Stress in Emergency Healthcare Workers

Author

Bouillon-Minois, Jean-Baptiste, primary, Outrey, Justin, additional, Pereira, Bruno, additional, Adeyemi, Oluwaseun John, additional, Sapin, Vincent, additional, Bouvier, Damien, additional, Thivel, David, additional, de Saint-Vincent, Sarah, additional, Ugbolue, Ukadike Chris, additional, Baker, Julien S., additional, Bagheri, Reza, additional, Schmidt, Jeannot, additional, Trousselard, Marion, additional, and Dutheil, Frédéric, additional

Published
2022
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41. Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial

Author

Bistervels, Ingrid M, primary, Buchmüller, Andrea, additional, Wiegers, Hanke M G, additional, Ní Áinle, Fionnuala, additional, Tardy, Bernard, additional, Donnelly, Jennifer, additional, Verhamme, Peter, additional, Jacobsen, Anne F, additional, Hansen, Anette T, additional, Rodger, Marc A, additional, DeSancho, Maria T, additional, Shmakov, Roman G, additional, van Es, Nick, additional, Prins, Martin H, additional, Chauleur, Céline, additional, Middeldorp, Saskia, additional, van den Akker, Eline S, additional, Bekker, Mireille N, additional, van Bemmel, Thomas, additional, Bertoletti, Laurent, additional, Blanc, Julie, additional, Bleker, Suzanne M, additional, Bourtembourg-Matras, Aude, additional, Bretelle, Florence, additional, Byrne, Bridgette, additional, Couturaud, Francis, additional, Delorme, Pierre, additional, Eerenberg, Elise S, additional, Franssen, Maureen TM, additional, Fuglsang, Jens, additional, Ganzevoort, Wessel, additional, Goffinet, François, additional, de Haan-Jebbink, Jiska M, additional, Heidema, Wieteke, additional, Hertzberg, Monique A, additional, Hovens, Marcel MC, additional, Huisman, Menno V, additional, de Jong-Speksnijder, Leonie, additional, Kamphuisen, Pieter-Willem, additional, O'Keeffe, Denis J, additional, Lacut, Karine, additional, Langenveld, Josje, additional, Lunshof, M Simone, additional, Martens, Caroline P, additional, Merah, Adel, additional, Le Moigne, Emmanuelle, additional, Papatsonis, Dimitri NM, additional, Pernod, Gilles, additional, Perrotin, Franck, additional, Peynaud-Debayle, Edith, additional, Pierre, Fabrice, additional, Plu Bureau, Geneviève, additional, Raia-Barjat, Tiphaine, additional, Rijnders, Robbert JP, additional, Rosario, Roger, additional, Ruivard, Marc, additional, Schmidt, Jeannot, additional, Sueters, Marieke, additional, Vanassche, Thomas, additional, Varlet, Marie-Noëlle, additional, Vivanti, Alexandre J, additional, van der Vlist, Matthieu Y, additional, van der Voet, Lucet F, additional, Vollebregt, Karlijn C, additional, de Vries, Johanna IP, additional, de Weerd, Sabina, additional, Westerweel, Peter E, additional, Wijnberger, Lia DE, additional, ten Wolde, Marije, additional, Ypma, Paula F, additional, Zuily-Lamy, Catherine, additional, Zwart, Joost J, additional, Benachi, Alexandra, additional, Beucher, Gaël, additional, Bezanahary, Holy, additional, de Boer, Karin, additional, de Boer, Marjon A., additional, Bousquet, Frantz, additional, Bremer, Henk A., additional, Bressollette, Luc, additional, Brossard, Aurélie, additional, Chau, Cécile, additional, Cleary, Brian, additional, Comte, Fabienne, additional, Corsini, Thomas, additional, Coustel, Anne, additional, Debaveye, Barbara, additional, Desbrière, Raoul, additional, Duvillard, Cécile, additional, Eckman, Astrid, additional, Eikenboom, Jeroen, additional, Elias, Antoine, additional, Faber, Laura M., additional, Ferrari, Emile, additional, Gallot, Denis, additional, Gauchotte, Emilie, additional, Gaugler, Ingrid, additional, Geerlings, Abby E., additional, O'Gorman, Audrey, additional, Grobost, Vincent, additional, de Groot, Pieter-Kees, additional, van der Ham, David P., additional, Hermsen, Brenda, additional, Kamphorst, Kim, additional, Karovitch, Alan, additional, Kleiverda, Gunilla, additional, Kloster, Aiste, additional, Koops, Annemarieke, additional, Krabbendam, Inneke, additional, Kruip, Marieke J.H.A., additional, Kuipers, Saskia, additional, van Laar, Judith, additional, Laneelle, Damien, additional, Lima, Suzanne, additional, MacMahon, Peter, additional, Mandelbrot, Laurent, additional, van Meir, Claudia A., additional, Menez, Caroline, additional, Morssink, Leonard P., additional, Moulin, Nathalie, additional, Mousty, Eve, additional, Muller, Matthieu, additional, Murphy, Lucy, additional, Peerlinck, Kathelijne, additional, O'Reilly, Alma, additional, de Reus, Maartje, additional, Le Roux, Magali Hilmi, additional, Ryan, Kevin, additional, Samren, Bettina, additional, Schippers, Daniela, additional, Schuitemaker, Nico, additional, Schweizer, Chloé, additional, van der Straaten, Hanneke, additional, Tromeur, Cécile, additional, Vanheule, Kristine, additional, Verhagen, Tamara, additional, Visser, Jantien, additional, Watts, Michael, additional, van Wijngaarden, Wim J., additional, Woiski, Mallory, additional, and Zelis, Maartje, additional

Published
2022
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43. Designing and conducting a cluster-randomized trial of ICU admission for the elderly patients: the ICE-CUB 2 study

Author

Boumendil, Ariane, Woimant, Maguy, Quenot, Jean-Pierre, Rooryck, François-Xavier, Makhlouf, Foued, Yordanov, Youri, Delerme, Samuel, Takun, Khalil, Ray, Patrick, Kouka, Marie-Clément, Poly, Claire, Garrouste-Orgeas, Maité, Thomas, Caroline, Simon, Tabasome, Azerad, Sylvie, Leblanc, Guillaume, Pateron, Dominique, Guidet, Bertrand, Guidet, Bertrand, Pateron, Dominique, Yordanov, Youri, Debuc, Erwan, Dreyfuss, Didier, Ricard, Jean-Damien, Brun, Patrick, Leroy, Christophe, Cohen, Yves, Adnet, Frédéric, Woimant, Maguy, Mira, Jean-Paul, Doumenc, Benoit, Takun, Khalil, Similowski, Thomas, Riou, Bruno, Delerme, Samuel, Quenot, Jean-Pierre, Honnart, Didier, Timsit, Jean-François, Gueringuerin, Pierrick, Guerin, Françoise, Maignan, Maxime, Makhlouf, Foued, Poussel, Jean-François, Braun, François, Fourrier, François, Goldstein, Patrick, Williatte, Pierre, Gosselin, Pierre, Wiel, Eric, Santoli, Francesco, Charestan, Pierre, Poly, Claire, Mentec, Hervé, Le Gall, Catherine, Sahraoui, Karima, Baillard, Christophe, Pontual, Loïc, Javaud, Nicolas, Misset, Benoît, Garrouste-Orgeas, Maité, Ganansia, Olivier, Rooryck, François-Xavier, Aim, Jean Luc, El Rifai, Abudlrazak, Rooryck, François-Xavier, Reignier, Jean, Martin-Lefevre, Laurent, Fradin, Philippe, Mauriat, Claire, Cwicklinski, Emelyne, Dupont, Hervé, Slama, Michel, Ammirati, Christine, Gallou, Justine, Fartoukh, Muriel, Djibre, Michel, Ray, Patrick, Rouff, Edwin, Souweine, Bertrand, Ait Hssain, Ali, Schmidt, Jeannot, Pic, Daniel, Moustafa, Farès, Mercat, Alain, Lerolle, Nicolas, Roy, Pierre-Marie, Baud, Frédéric, Plaisance, Patrick, Montagnon, Sophie, Galichon, Bertrand, Wolff, Michel, Mourvillier, Bruno, Casalino, Enrique, Choquet, Christophe, Bernard, Juillien, Gaëlle, Fagon, Jean-Yves, Guerot, Emmanuel, Juvin, Philippe, Patzak, Anabela, Verdiere, Bruno, Ioos, Vincent, Kouka, Marie-clément, Berthoumieu, Audrey, Richard, Christian, Anguel, Nadia, Maurice, Raphael, Sarnel, Sophie, Diez, Stéphane, Vieillard Baron, Antoine, Beaune, Sébastien, Grenet, Julie, and on behalf of the ICE-CUB 2 study network

Published
2016
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44. Simple Aspiration versus Drainage for Complete Pneumothorax A Randomized Noninferiority Trial.

Author

Marx, Tania, Joly, Luc-Marie, Parmentier, Anne-Laure, Pretalli, Jean-Baptiste, Puyraveau, Marc, Meurice, Jean-Claude, Schmidt, Jeannot, Tiffet, Olivier, Ferretti, Gilbert, Lauque, Dominique, and Honnart, Didier

Abstract

Rationale: Management of first episodes of primary spontaneous pneumothorax remains the subject of debate. Objectives: To determine whether first-line simple aspiration is noninferior to first-line chest tube drainage for lung expansion in patients with complete primary spontaneous pneumothorax. Methods: We conducted a prospective, open-label, randomized noninferiority trial. Adults aged 18–50 years with complete primary spontaneous pneumothorax (total separation of the lung from the chest wall), recruited at 31 French hospitals from 2009 to 2015, received simple aspiration (n = 200) or chest tube drainage (n = 202) as first-line treatment. The primary outcome was pulmonary expansion 24 hours after the procedure. Secondary outcomes were tolerance of treatment, occurrence of adverse events, and recurrence of pneumothorax within 1 year. Substantial discordance in the numerical inputs used for trial planning and the actual trial rates of the primary outcome resulted in a reevaluation of the trial analysis plan. Measurement and Main Results: Treatment failure occurred in 29% in the aspiration group and 18% in the chest tube drainage group (difference in failure rate, 0.113; 95% confidence interval [CI], 0.026–0.200). The aspiration group experienced less pain overall (mean difference, −1.4; 95% CI, −1.89, −0.91), less pain limiting breathing (frequency difference, −0.18; 95% CI, −0.27, −0.09), and less kinking of the device (frequency difference, −0.05; 95% CI, −0.09, −0.01). Recurrence of pneumothorax was 20% in this group versus 27% in the drainage group (frequency difference, −0.07; 95% CI, −0.16, +0.02). Conclusions: First-line management of complete primary spontaneous pneumothorax with simple aspiration had a higher failure rate than chest tube drainage but was better tolerated with fewer adverse events. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Classifying heartrate by change detection and wavelet methods for emergency physicians

Author

Azzaoui Nourddine, Guillin Arnaud, Dutheil Frederic, Boudet Gil, Chamoux Alain, Perrier Christophe, Schmidt Jeannot, and Bertrand Pierre Raphaël

Subjects
Applied mathematics. Quantitative methods, T57-57.97, Mathematics, QA1-939
Abstract

Heart Rate Variability (HRV) carries a wealth of information about the physiological state and the behaviour of a living individual. Indeed, the heart rate variation is intrinsically linked to the autonomic nervous system: the parasympathetic and orthosympathetic systems. Thus, any imbalance in these two opposite systems results in a variation of the cardiac frequency modulation. This alternation between equilibrium and disequilibrium (frequency variability) is recognized as an indicator of well-being and good health. Particularly, decreased HRV is linked to stress, fatigue and decreased physical performance. The aim of this work is to exploit the heart rate signals to detect stressful situations in different populations: emergency physicians, sportsmen, animal behaviours...We introduce a methodological framework for the detection of stress and eventually well-being. Our contribution is firstly based on using Gabor wavelets to extract energies corresponding to High and Low Frequency (HF and LF) bands which are linked to the parasympathetic and orthosympathetic systems. We then detect change points on these energies using the Filtered Derivative with p-value (FDpV) method. Finally, we develop a typology of cardiac activity by distinguishing homogeneous groups or state profiles sharing similar characteristics. We apply our methodology on a real dataset collected by monitoring cardiac activity of an emergency physician for 24 hours.

Published
2014
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50. The Use of a Fixed 50:50 Mixture of Nitrous Oxide and Oxygen to Reduce Lumbar Puncture-Induced Pain in the Emergency Department: A Randomized Controlled Trial

Author

Nicot, Mélissandre, primary, Miraillet, Ludovic, additional, Pereira, Bruno, additional, Bouillon-Minois, Jean-Baptiste, additional, Raconnat, Julien, additional, Moustafa, Farès, additional, Schmidt, Jeannot, additional, Sickout-Arondo, Sophia, additional, Bernard, Lise, additional, Clavelou, Pierre, additional, and Moisset, Xavier, additional

Published
2022
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