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Depth-integrated primary productivity (PP) estimates obtained from satellite ocean color-based models (SatPPMs) and those generated from biogeochemical ocean general circulation models (BOGCMs) represent a key resource for biogeochemical and ecological studies at global as well as regional scales. Calibration and validation of these PP models are not straightforward, however, and comparative studies show large differences between model estimates. The goal of this paper is to compare PP estimates obtained from 30 different models (21 SatPPMs and 9 BOGCMs) to a tropical Pacific PP database consisting of ∼ 1000 14C measurements spanning more than a decade (1983-1996). Primary findings include: skill varied significantly between models, but performance was not a function of model complexity or type (i.e. SatPPM vs. BOGCM); nearly all models underestimated the observed variance of PP, specifically yielding too few low PP (< 0.2 g C m- 2 d- 1) values; more than half of the total root-mean-squared model-data differences associated with the satellite-based PP models might be accounted for by uncertainties in the input variables and/or the PP data; and the tropical Pacific database captures a broad scale shift from low biomass-normalized productivity in the 1980s to higher biomass-normalized productivity in the 1990s, which was not successfully captured by any of the models. This latter result suggests that interdecadal and global changes will be a significant challenge for both SatPPMs and BOGCMs. Finally, average root-mean-squared differences between in situ PP data on the equator at 140°W and PP estimates from the satellite-based productivity models were 58% lower than analogous values computed in a previous PP model comparison 6 years ago. The success of these types of comparison exercises is illustrated by the continual modification and improvement of the participating models and the resulting increase in model skill. © 2008 Elsevier B.V.

We use a finite-element model of coupled ice-stream/ice-shelf flow to study the sensitivity of Pine Island Glacier, West Antarctica, to changes in ice-shelf and basal conditions. By tuning a softening coefficient of the ice along the glacier margins, and a basal friction coefficient controlling the distribution of basal shear stress underneath the ice stream, we are able to match model velocity to that observed with interferometric synthetic aperture radar (InSAR). We use the model to investigate the effect of small perturbations on ice flow. We find that a 5.5 13% reduction in our initial ice-shelf area increases the glacier velocity by 3.5 10% at the grounding line. The removal of the entire ice shelf increases the grounding-line velocity by > 70%. The changes in velocity associated with ice-shelf reduction are felt several tens of km inland. Alternatively, a 5% reduction in basal shear stress increases the glacier velocity by 13% at the grounding line. By contrast, softening of the glacier side margins would have to be increased a lot more to produce a comparable change in ice velocity. Hence, both the ice-shelf buttressing and the basal shear stress contribute significant resistance to the flow of Pine Island Glacier.

Interferometric synthetic aperture radar (InSAR) observations of ice-shelf tidal deformation reveal the wide transition between grounded and floating ice as well as local areas where the ice shelf is only grounded at low tide, a condition that we call ephemeral grounding. Ephemeral grounding creates a subtle, local disturbance on the vertical motion field of the ice-shelf surface in response to changes in occanic tide which is detected with millimetric precision using InSAR. These ice-shelf features are, however, not expected to produce a noticeable disturbance on the ice-shelf velocity field. To illustrate the influence of ephemeral grounding on ice-shelf creep flow, we use a finite-element model in which ephemeral grounding is incorporated through a variable basal friction coefficient. The results show that while ice rises (permanently grounded areas) have a pronounced influence on the ice-shelf velocity field, areas of ephemeral grounding have a vanishingly small influence. What is thus of most interest is the capacity for observations of ephemeral grounding to reveal subtle changes in ice-shelf thickness over time. We discuss an example in the Thwaites Glacier area, West Antarctica, where multi-year data show how ice rises become ephemeral grounding and subsequently disappear. This result is consistent with the grounding-line retreat and ice thinning of Thwaites Glacier.

Tides near and under floating glacial ice, such as ice shelves and glacier termini in fjords, can influence heat transport into the subice cavity, mixing of the under-ice water column, and the calving and subsequent drift of icebergs. Free-surface displacement patterns associated with ocean variability below glacial ice can be observed by differencing two synthetic aperture radar (SAR) interferograms, each of which represents the combination of the displacement patterns associated with the time-varying vertical motion and the time-independent lateral ice flow. We present the pattern of net free-surface displacement for the iceberg calving regions of the Ronne and Filchner Ice Shelves in the southern Weddell Sea. By comparing SAR-based displacement fields with ocean tidal models, the free-surface displacement variability for these regions is found to be dominated by ocean tides. The inverse barometer effect, i.e., the ocean's isostatic response to changing atmospheric pressure, also contributes to the observed vertical displacement. The principal value of using SAR interferometry in this manner lies in the very high lateral resolution (tens of meters) obtained over the large region covered by each SAR image. Small features that are not well resolved by tile typical grid spacing of ocean tidal models may contribute to such processes as iceberg calving and cross-frontal ventilation of the ocean cavity under the ice shelf. Copyright 2000 by the American Geophysical Union.

Synthetic-aperture radar interferometry data and airborne ice-sounding radar (ISR) data are employed to obtain modern estimates of the inland ice production from Nioghalvfjerdsbrae (NB) and Zachariae Isstrom (ZI), the two largest glaciers draining the northeast sector of the Greenland ice sheet. Ice fluxes are measured at the grounding line (14.2 ± 1 km3 ice a-1 for NB and 10.8 ± 1 km3 ice a-1 for ZI) with an ice thickness deduced from ice-shelf hydrostatic equilibrium, and along an ISR profile collected upstream of the grounding line (14.3 ± 0.7 km3 ice a-1 for NB and 11.6 ± 0.6 km3 ice a-1 for ZI). Balance fluxes calculated from a map of snow accumulation and model predictions of surface melt are 11.9 ± 2 km3 ice a-1 for NB and 10.0 ± 2 km3 ice a-1 for ZI at the grounding line, and 12.2 and 10.3 km3 ice a-1, respectively, at the ISR line. The two glaciers therefore exhibit a negative mass balance equivalent to 14% of their balance flux, with a ±12% uncertainty. Independently, we detect a retreat of the grounding line of NB between 1992 and 1996 which is larger at the glacier center (920 ± 250 m) than on the sides (240 ± 50 m). The corresponding ice-thinning rates (2±1 m a-1 at the glacier center and 0.6±0.3 m a-1 on the sides) are too large to be accommodated by temporal changes in ablation or accumulation, and must be due to dynamic thinning.

Electrical breakdown sets a limit on the kinetic energy that particles in a conventional radio-frequency accelerator can reach. New accelerator concepts must be developed to achieve higher energies and to make future particle colliders more compact and affordable. The plasma wakefield accelerator (PWFA) embodies one such concept, in which the electric field of a plasma wake excited by a bunch of charged particles (such as electrons) is used to accelerate a trailing bunch of particles. To apply plasma acceleration to electron-positron colliders, it is imperative that both the electrons and their antimatter counterpart, the positrons, are efficiently accelerated at high fields using plasmas (1). Although substantial progress has recently been reported on high-field, high-efficiency acceleration of electrons in a PWFA powered by an electron bunch (2), such an electron-driven wake is unsuitable for the acceleration and focusing of a positron bunch. Here we demonstrate a new regime of PWFAs where particles in the front of a single positron bunch transfer their energy to a substantial number of those in the rear of the same bunch by exciting a wakefield in the plasma. In the process, the accelerating field is altered--'self-loaded'--so that about a billion positrons gain five gigaelectronvolts of energy with a narrow energy spread over a distance of just 1.3 metres. They extract about 30 per cent of the wake's energy and form a spectrally distinct bunch with a root-mean-square energy spread as low as 1.8 per cent. This ability to transfer energy efficiently from the front to the rear within a single positron bunch makes the PWFA scheme very attractive as an energy booster to an electron-positron collider., Future high-energy particle colliders will operate at the frontier of particle physics, with particle energies in the range of several trillion electronvolts (3). Beyond the Large Hadron Collider (LHC) at [...]

The Gironde estuary, one of the largest European ones, presents temporary low dissolved oxygen content in its fluvial section close to the Bordeaux urban area. In a context of population growth and of long-term environmental changes, the development of a high-frequency monitoring programme of the fluvial-estuarine system of the Gironde, called MAGEST (MArel Gironde ESTuary), had appeared essential to address current and future water-quality issues/evaluations. The objectives of the MAGEST survey programme are to establish a reference database to improve the knowledge of the Gironde estuary functioning, encompassing the aspects of hydrology, sediment dynamics and biogeochemistry. Through examples of results from intratidal to seasonal time scales, we demonstrate how such a time-series is of valuable interest to extract the main trends of its functioning and of the water quality in relation to external forcings (climatology, urban wastes, land use, …) and to predict the future evolution of the Gironde estuary with global and environmental changes. [ABSTRACT FROM AUTHOR]

Controlling the assembly of high-order structures is central to soft-matter and biomaterial engineering. Angle-resolved linear dichroism can probe the ordering of chiral collagen molecules in the dense state. Collagen triple helices were aligned by solvent evaporation. Their ordering gives a strong linear dichroism (LD) that changes sign and intensity with varying sample orientations with respect to the beam linear polarization. Being complementary to circular dichroism, which probes the structure of chiral (bio)molecules, LD can shift from the molecular to the supramolecular scale and from the investigation of the conformation to interactions. Supported by multiphoton microscopy and X-ray scattering, we show that LD provides a straightforward route to probe collagen alignment, determine the packing density, and monitor denaturation. This approach could be adapted to any assembly of chiral (bio)macromolecules, with key advantages in detecting large-scale assemblies with high specificity to aligned and chiral molecules and improved sensitivity compared to conventional techniques.

The auditory ossicles amplify and transmit sound from the environment to the inner ear. The distribution of bone mineral density is crucial for the proper functioning of sound transmission as the ossicles are suspended in an air-filled chamber. However, little is known about the distribution of bone mineral density along the human ossicular chain and within individual ossicles. To investigate this, we analyzed fresh-frozen human specimens using synchrotron-based phase-contrast microtomography. In addition, we analyzed the volume and porosity of the ossicles. The porosity for the auditory ossicles lies, on average, between 1.92% and 9.85%. The average volume for the mallei is 13.85 ± 2.15 mm 3 , for the incudes 17.62 ± 4.05 mm 3 and 1.24 ± 0.29 mm 3 for the stapedes. The bone density distribution showed a similar pattern through all samples. In particular, we found high bone mineralization spots on the anterior crus of the stapes, its footplate, and along areas that are crucial for the transmission of sound. We could also see a correlation between low bone mineral density and holey areas where the bone is only very thin or missing. Our study identified a similar pattern of bone density distribution within all samples: regions exposed to lower forces generally show higher bone density. Further, we observed that the stapes shows high bone mineral density along the anterior crus and its footplate, which may indicate its importance in transmitting sound waves to the inner ear., (© 2024. The Author(s).)

Purpose: There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV)., Methods: We examined three fresh-frozen temporal bones (TB) using dynamic synchrotron-based X-ray microtomography for 256 Hz and 512 Hz, stimulated at 110 dB and 120 dB SPL. In addition, we performed measurements on these TBs using 1D LDV, a well-established method., Results: The normalized displacement values (μm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5-10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques., Conclusion: In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear's biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.

The characterization of the vibrations of the middle ear ossicles during sound transmission is a focal point in clinical research. However, the small size of the structures, their micrometer-scale movement, and the deep-seated position of the middle ear within the temporal bone make these types of measurements extremely challenging. In this work, dynamic synchrotron-based X-ray phase-contrast microtomography is used on acoustically stimulated intact human ears, allowing for the three-dimensional visualization of entire human eardrums and ossicular chains in motion. A post-gating algorithm is used to temporally resolve the fast micromotions at 128 Hz, coupled with a high-throughput pipeline to process the large tomographic datasets. Seven ex-vivo fresh-frozen human temporal bones in healthy conditions are studied, and the rigid body motions of the ossicles are quantitatively delineated. Clinically relevant regions of the ossicular chain are tracked in 3D, and the amplitudes of their displacement are computed for two acoustic stimuli., (© 2024. The Author(s).)

Background: Environmental racism, community stressors, and age-related susceptibility play a significant role in environmental inequality. The goal of this article was to use an inequality index (II) to assess the level of equality in environmental threats and hazards based on race, poverty, and age in Washington State. Methods: Using the Washington Environmental Health Disparities Map, we quantified the level of disproportionate burdens on communities with greater populations of people of color, people in poverty, children younger than 5, and people older than 65 using 3 cumulative environmental indices and 10 individual environmental indicators. Results: Census tracts with a higher proportion of people of color and those with people living below 185% federal poverty levels were found to be disproportionately burdened by environmental threats (II = -0.175 and II = -0.167, respectively, p  < 0.001). Individual environmental indicators were found to disproportionately burden communities of color and low-income communities. Children younger than 5 were also disproportionately burdened by cumulative environmental indices (II = -0.076, p  < 0.001) and individual indicators. Our analysis did not show disproportionate burden of environmental health threats based on the proportion of people older than 65 (II = 0.124, p  < 0.001). Discussion: The disproportionate burden of the cumulative environmental threats on communities of color and low-income communities in this study corroborates similar analyses. These findings can be applied in policy and regulatory actions to correct the distributive environmental disparities. Conclusion: We found much higher burdens among historically marginalized communities and children who are more susceptible to environmental threats and hazards., Competing Interests: No competing financial interests exist., (Copyright 2021, Mary Ann Liebert, Inc., publishers.)

Nondestructive and noninvasive investigation techniques are highly sought-after to establish the degradation state of historical parchments, which is up to now assessed by thermal techniques that are invasive and destructive. We show that advanced nonlinear optical (NLO) microscopy enables quantitative in situ mapping of parchment degradation at the micrometer scale. We introduce two parameters that are sensitive to different degradation stages: the ratio of two-photon excited fluorescence to second harmonic generation (SHG) signals probes severe degradation, while the anisotropy parameter extracted from polarization-resolved SHG measurements is sensitive to early degradation. This approach is first validated by comparing NLO quantitative parameters to thermal measurements on artificially altered contemporary parchments. We then analyze invaluable parchments from the Middle Ages and show that we can map their conservation state and assess the impact of a restoration process. NLO quantitative microscopy should therefore help to identify parchments most at risk and optimize restoration methods., (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).)

The human cornea is mainly composed of collagen fibrils aligned together within stacked lamellae. This lamellar structure can be affected in pathologies such as keratoconus, which is characterized by progressive corneal thinning and local steepening. In this study, we use polarization-resolved second harmonic generation (P-SHG) microscopy to characterize 8 control and 6 keratoconic human corneas. Automated processing of P-SHG images of transverse sections provides the collagen orientation in every pixel with sub-micrometer resolution. Series of P-SHG images recorded in the most anterior region of the stroma evidence sutural lamellae inclined at 22° ± 5° to the corneal surface, but show no significant difference between control and keratoconic corneas. In contrast, series of P-SHG images acquired along the full thickness of the stroma show a loss of order in the lamellar structure of keratoconic corneas, in agreement with their defective mechanical properties. This structural difference is analyzed quantitatively by computing the entropy and the orientation index of the collagen orientation distribution and significant differences are obtained along the full thickness of the stroma. This study shows that P-SHG is an effective tool for automatic quantitative analysis of structural defects of human corneas and should be applied to other collagen-rich tissues., Competing Interests: The authors declare no conflicts of interest., (© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.)

Communities across Washington State have expressed the need for neighborhood-level information on the cumulative impact of environmental hazards and social conditions to illuminate disparities and address environmental justice issues. Many existing mapping tools have not explicitly integrated community voice and lived experience as an integral part of their development. The goals of this project were to create a new community-academic-government partnership to collect and summarize community concerns and to develop a publicly available mapping tool that ranks relative environmental health disparities for populations across Washington State. Using a community-driven framework, we developed the Washington Environmental Health Disparities Map, a cumulative environmental health impacts assessment tool. Nineteen regularly updated environmental and population indicators were integrated into the geospatial tool that allows for comparisons of the cumulative impacts between census tracts. This interactive map provides critical information for the public, agencies, policymakers, and community-based organizations to make informed decisions. The unique community-academic-government partnership and the community-driven framework can be used as a template for other environmental and social justice mapping endeavors.

Second harmonic generation (SHG) enables in situ imaging of fibrillar collagen architecture in connective tissues. Recently, Circular Dichroism SHG (CD-SHG) microscopy has been implemented to take advantage of collagen chirality to improve 3D visualization. It measures the normalized difference in the SHG signal obtained upon excitation by left versus right circular polarizations. However, CD-SHG signal is not well characterized yet, and quite different CD-SHG values are reported in the literature. Here, we identify two major artifacts that may occur in CD-SHG experiments and we demonstrate that thorough optimization and calibration of the experimental setup are required for CD-SHG imaging. Notably it requires a careful calibration of the incident circular polarizations and a perfect mechanical stabilization of the microscope stage. Finally, we successfully record CD-SHG images in human cornea sections and confirm that this technique efficiently reveals collagen fibrils oriented out of the focal plane.

Conventional second harmonic generation (SHG) microscopy might not clearly reveal the structure of complex samples if the interference between all scatterers in the focal volume results in artefactual patterns. We report here the use of interferometric second harmonic generation (I-SHG) microscopy to efficiently remove these artifacts from SHG images. Interfaces between two regions of opposite polarity are considered because they are known to produce imaging artifacts in muscle for instance. As a model system, such interfaces are first studied in periodically-poled lithium niobate (PPLN), where an artefactual incoherent SH signal is obtained because of irregularities at the interfaces, that overshadow the sought-after coherent contribution. Using I-SHG allows to remove the incoherent part completely without any spatial filtering. Second, I-SHG is also proven to resolve the double-band pattern expected in muscle where standard SHG exhibits in some regions artefactual single-band patterns. In addition to removing the artifacts at the interfaces between antiparallel domains in both structures (PPLN and muscle), I-SHG also increases their visibility by up to a factor of 5. This demonstrates that I-SHG is a powerful technique to image biological samples at enhanced contrast while suppressing artifacts., Competing Interests: The authors declare that there are no conflicts of interest related to this article.