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2. A sub-study of the POISE-3 randomized trial examined effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury

Author

Garg, Amit X., Marcucci, Maura, Cuerden, Meaghan S., Sontrop, Jessica M., Painter, Thomas W., Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Leslie, Kate, Duceppe, Emmanuelle, Parikh, Chirag R., Roshanov, Pavel, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Meyhoff, Christian S., Short, Timothy G., Amir, Mohammed, Torres, David, Wittmann, Maria, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel L., Jayaram, Raja, Polanczyk, Carisi A., Fleischmann, Edith, Tandon, Vikas, Astrakov, Sergey V., Conen, David, Kei Wu, William Ka, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Ofori, Sandra N., Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce M., Srinathan, Sadeesh, Ismoilov, Samandar, Wang, Michael Ke, Kurz, Andrea, Belley-Cote, Emilie P., Bhatt, Keyur, Eikelboom, John, Gross, Peter, Lamy, Andre, McGillion, Michael, McIntyre, William, Richards, Toby, Spence, Jessica, Van Helder, Thomas, Whitlock, Richard, and Devereaux, P.J.

Published
2024
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4. Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial

Author

Conen, David, Devereaux, PJ, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew TV, Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit, Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Ofori, Sandra N., Blum, Steffen, Alvarez-Garcia, Jesus, Lo Bianco, Giuliana, Traquair, Hugh, Guerrero-Pinedo, Fernando Andres, Oleynick, Christopher, Meyre, Pascal B., Méndez-Zurita, Francisco, Chiarella-Redfern, Helene, Marcucci, Maura, Donati, Francesco, Gonzalez-Osuna, Aranzazu, Minervini, Fabrizio, Moreno Weidmann, Zoraida, Guerra-Ramos, Jose M., Dion, Gabriel, Ramos-Pachón, Anna, Borges, Flavia K., de Sa Boasquevisque, Danielle, Mosconi, Maria Giulia, Amarenco, Pierre, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Burns, Andrew T., Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Popovic, Michelle, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Hoetzenecker, Konrad, Schweiger, Thomas, Reiterer, Christian, Zotti, Oliver, Bsuchner, Paul, Hochreiter, Beatrix, Taschner, Alexander, Adamowitsch, Nikolas, Horvath, Katharina, Hantáková, Nicole, Bidgoli, Javad, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, Rushton, Jacob, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Tanzola, Rob, Giles, Andrew, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Yee, John, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Durkin, Christopher, Schisler, Travis, Hecht, Patrick, Hughes, Bevan, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, Dubik, Niina, Chin, Alex, Maziak, Donna E., Seely, Andrew JE, Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Haider, Tehmina, Murphy, Rowan, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Ko, Michael Augustine, Parente, David, Cheung, Victoria, Schieman, Colin, Bessissow, Amal, Wong, Randolph HL, Joynt, Gavin M., Lam, Carmen KM, Lau, Rainbow WH, Wan, Innes YP, Underwood, Malcolm J., Wu, William KK, Wong, Wai Tat, Choi, Gordon YS, Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Ng, Fung Kei, Thung, Kin Hoi, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, Baiardo-Redaelli, Martina, Belletti, Alessandro, Dieci, Elisa, Monaco, Fabrizio, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Viscardi, Stefano, Veronesi, Giulia, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Ceraolo, Edoardo, Neitzert, Luca, Brazzi, Luca, Londero, Francesco, Grossi, William, Massullo, Domenico, Fiorelli, Silvia, Margaritora, Stefano, Hashim, Shahrul Amry, Krishnasamy, Sivakumar, See, Woan Shiang, Nawaz, Mohammed Asghar, Bilal, Haris, Trujillo Reyes, Juan Carlos, Martínez-Téllez, Elisabeth, Belda Sanchis, Josep, Planas Canovas, Georgina, Libreros Niño, Alejandra, Parera Ruiz, Ana, Cladellas Gutierrez, Esther, Guarino, Mauro, Urrutia Cuchi, Gerard, Argilaga Nogues, Marta, Rovira Juan, Anna, Medina-Aedo, Melixa, Turró Castillejo, Mª Asunción, Gil Sanchez, Josep Mª, Araúz-Sarmiento, Ibell, Herranz Perez, Gracia, Chavarria Murillo, Stephania, Garcia-Osuna, Alvaro, Rodriguez-Arias, Ainhoa, Berga Garrote, Nuria, Martín Grande, Ascension, Parise Roux, Diego, Gajate Martín, Luis, De Pablo Pajares, Angélica, Candela Toha, Angel Manuel, Moreno Mata, Nicolás, Muñoz Molina, Gema, Caballero Silva, Usue, Cabañero, Alberto, Fra Fernandez, Sara, Cavestany García-Matres, Cristina, Simón, Luisa, Montenegro, Cristina, Pozo, Sergio, Gonzàlez-Tallada, Anna, González Suarez, Susana, Ribas Ball, Montserrat, De Nadal Clanchet, Miriam, Pérez Vélez, Javier, Cruz, Patrícia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, González, Guillermo, Huerta, Luis, Rodríguez, Laura, Garutti, Ignacio, Ruiz-Villa, Laura, Martí-Ejarque, Maria del Mar, Gili-Bueno, Mireia, Maddio Vieyra, Ricardo Matias, Fibla, Juan J., Durán, Núria, de Temple Pla, Marina, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Opitz, Isabelle, Etienne, Harry, Cata, Juan P., Guerra-Londono, Juan Jose, Rajaram, Ravi, Corrales, German, Vaporciyan, Ara, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Rice, David, Cukierman, Daniel S., Swisher, Stephen, Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Ayad, Sabry, Araujo, Jorge, Marquez-Roa, Leonardo, Hofstra, Richard L., Wudel, Jr., Leonard J., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Marsack, Kelly, Meehan, Sarah, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Ke Wang, Michael, Chan, Matthew T V, Cata, Juan P, McLean, Sean R, Srinathan, Sadeesh K, Reyes, Juan Carlos Trujillo, Grande, Ascension Martín, Tallada, Anna Gonzalez, Sessler, Daniel I, Maziak, Donna E, McIntyre, William F, Wong, Randolph H L, McGuire, Anna L, Roux, Diego Parise, Wells, Jennifer R, Ofori, Sandra N, Eikelboom, John W, Jolly, Sanjit S, Healey, Jeff S, and Devereaux, P J

Published
2023
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5. Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial

Author

Devereaux, Vincent, Jessica, Wang, Michael Ke, Wells, Jennifer R., Conen, David, Devereaux, PJ, Healey, Jeff S., Landoni, Giovanni, McIntyre, William F., Popova, Ekaterine, Sessler, Daniel I., Srinathan, Sadeesh K., Amir, Mohammed, Bangdiwala, Shrikant I., Bossard, Matthias, Chan, Matthew T.V., Eikelboom, John W., Fleischmann, Edith, Jolly, Sanjit S., Montes, Felix Ramón, Reimer, Cara, Schmartz, Denis, Wang, Chew Yin, Alvarez-Garcia, Jesus, Bianco, Giuliana Lo, Blum, Steffen, Boasquevisque, Danielle de Sa, Borges, Flavia K., Chiarella-Redfern, Helene, Gonzalez-Osuna, Aranzazu, Guerra-Ramos, Jose M., Marcucci, Maura, Meyre, Pascal B., Ofori, Sandra N., Oleynick, Christopher, Ramos-Pachón, Anna, Traquair, Hugh, Mitchell, L. Brent, Wyse, George, Cheng, Davy, McAlister, Finlay A., Wells, George A., Baskaran, Geethan, Gennaccaro, Julia, Howe, Rosemary, Mastrangelo, Louise, Pettit, Shirley, Shahbaz, Subana, Tosh, Makayla, Zucchetto, Simona J., Heenan, Laura, Lee, Shun Fu, Li, Zhuoru, Xu, Lizhen, Kabon, Barbara, Reiterer, Christian, Taschner, Alexander, Horvath, Katharina, Adamowitsch, Nikolas, Zotti, Oliver, Hantáková, Nicole, Hochreiter, Beatrix, Huybrechts, Isabelle, Cappeliez, Serge, Neary, John D., Shargall, Yaron, Tandon, Vikas, Finley, Christian, Agzarian, John, Hanna, Waël, Abdulrahman, Muammar, Lawrence, Kelly, Gregus, Krysten, Quraishi, Faraaz, Wikkerink, Spencer, Wallace, Christine, Prine, Merissa, Gregus, Emily, Hare, Jacqueline, Lombardo, Kristen, Fezia, Behashta, Columbus, Teresa, DuMerton, Deborah, Reid, Ken, Parlow, Joel, Chung, Wiley, Karizhenskaia, Maria, Malik, Aftab, Kidane, Biniam, Liu, Richard, Tan, Lawrence, Gowing, Stephen, Buduhan, Gordon, Enns, Stephanie, Poole, Emma, Graham, Kristin, McLean, Sean R., McGuire, Anna, Lohser, Jens, Lim, Shirley, Grey, Rebecca, Grant, Kyle, Lee, Alex L., Choi, James J., Dewar, Leith R., Yee, John, Maziak, Donna E., Seely, Andrew J.E., Gilbert, Sebastien, Villeneuve, P. James, Sundaresan, Sudhir, Moffatt-Bruce, Susan D., Gingrich, Molly, Fazekas, Anna, Bucciero, Kirby, Malthaner, Richard A., Lewis, Deb, Fortin, Dalilah, Qiabi, Mehdi, Nayak, Rahul, Plourde, Madelaine Marie, Sellers, Daniel, Donahoe, Laura, Lefebvre, Marco, Lanthier, Luc, Schieman, Colin, Bessissow, Amal, Joynt, Gavin M., Wong, Randolph H.L., Lau, Rainbow W.H., Wong, Wai Tat, Choi, Gordon Y.S., Lee, Eva, Hui, Ka Yan, Fung, Beaker, Chan, Chee Sam, Gutiérrez-Soriano, Laura, Castañeda, Laura Carmenza, Téllez, Luis Jaime, Ortiz-Ramirez, Lina Marcela, De Santis, Simona, Favaro, Giovanni, Muriana, Piergiorgio, Nakhnoukh, Cristina, Novellis, Pierluigi, Turi, Stefano, Veronesi, Giulia, Angelini, Matteo, Voltolini, Luca, Bongiolatti, Stefano, Salvicchi, Alberto, Gatteschi, Lavinia, Indino, Rossella, Tombelli, Simone, Ravasin, Alice, Salimbene, Ottavia, Rosboch, Giulio Luca, Balzani, Eleonora, Massullo, Domenico, Fiorelli, Silvia, Londero, Francesco, Grossi, William, Ng, Tyng Yan, See, Woan Shiang, Nawaz, Mohammed Asghar, Reyes, Juan Carlos Trujillo, Tellez, Elisabeth Martinez, Sanchis, Josep Belda, Cánovas, Georgina Planas, Ruiz, Ana Parera, Gutierrez, Esther Cladellas, Guarino, Mauro, Cuchi, Gerard Urrutia, Nogues, Marta Argilaga, Juan, Anna Rovira, Medina-Aedo, Melixa, Grande, Ascensión Martín, Roux, Diego Parise, Martín, Luis Gajate, Pajares, Angélica De Pablo, Toha, Angel Manuel Candela, Mata, Nicolás Moreno, Molina, Gema Muñoz, Silva, Usue Caballero, Cabañero, Alberto, Fernandez, Sara Fra, Tallada, Anna Gonzàlez, Suarez, Susana González, Ball, Montserrat Ribas, Clanchet, Miriam De Nadal, Ruiz-Villa, Laura, Martí-Ejarque, M.M., Gili-Bueno, Mireia, Ferrández, Jorge Hernández, Llobet, Neus Pons, Cruz, Patricia, Sánchez-Pedrosa, Guillermo, Duque, Patricia, Azcárate, Leire, Martín-Albo, Lorena, Rodríguez-Fuster, Alberto, Bermejo-Martínez, Silvia, Carramiñana, Albert, Minervini, Fabrizio, Cata, Juan P., Rajaram, Ravi, Corrales, German, Guerra-Londono, Juan Jose, Mehran, Reza, Sepesi, Boris, Walsh, Garrett, Cukierman, Daniel S., Marchant, Bryan E., Harris, Lynne C., Cusson, Bruce D., Miller, Scott A., Minear, Steven C., Teixeira, Camila, Pimentel, Mario, Popoff, Andrew M., Cheung, Wing Lee, Marsack, Kelly, Ayad, Sabry, Araujo, Jorge, Chen, Tzonghuei H., Essandoh, Michael, Poppers, Jeremy S., Trujillo Reyes, Juan Carlos, Gonzalez Tallada, Anna, and Garg, Amit X.

Published
2023
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7. Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Martínez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Published
2022
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12. Assessment of haemostasis in pregnant women

Author

Zec, Tamara, primary, Schmartz, Denis, additional, Temmerman, Pomeline, additional, Fils, Jean-François, additional, Ickx, Brigitte, additional, Bonhomme, Fanny, additional, and Van Der Linden, Philippe, additional

Published
2024
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19. Detection of Cerebral Electroencephalographic Patterns After Median Nerve Stimulation During Propofol-Induced General Anesthesia: a Prospective Interventional Cohort Study

Author

Rimbert, Sébastien, Cueva, Valérie Marissens, Petieau, Mathieu, Bidgoli, Seyed Javad, Chéron, Guy, Cheffi, Zakaria, Cebolla Alvarez, Ana Maria, Schmartz, Denis, Rimbert, Sébastien, Cueva, Valérie Marissens, Petieau, Mathieu, Bidgoli, Seyed Javad, Chéron, Guy, Cheffi, Zakaria, Cebolla Alvarez, Ana Maria, and Schmartz, Denis

Abstract

info:eu-repo/semantics/published

Published
2023

20. Detection of Motor Cerebral Activity After Median Nerve Stimulation During General Anesthesia (STIM-MOTANA): Protocol for a Prospective Interventional Study

Author

Rimbert, Sébastien, Lelarge, Julien, Guerci, Philippe, Bidgoli, Seyed Javad, Meistelman, Claude, Chéron, Guy, Cebolla Alvarez, Ana Maria, Schmartz, Denis, others, Rimbert, Sébastien, Lelarge, Julien, Guerci, Philippe, Bidgoli, Seyed Javad, Meistelman, Claude, Chéron, Guy, Cebolla Alvarez, Ana Maria, Schmartz, Denis, and others

Abstract

info:eu-repo/semantics/published

Published
2023

21. Peri-operative management of neuromuscular blockade

Author

Fuchs-Buder, Thomas, Romero, Carolina S., Lewald, Heidrun, Lamperti, Massimo, Afshari, Arash, Hristovska, Ana-Marjia, Schmartz, Denis, Hinkelbein, Jochen, Longrois, Dan, Popp, Maria, de Boer, Hans D., Sorbello, Massimiliano, Jankovic, Radmilo, Kranke, Peter, Fuchs-Buder, Thomas, Romero, Carolina S., Lewald, Heidrun, Lamperti, Massimo, Afshari, Arash, Hristovska, Ana-Marjia, Schmartz, Denis, Hinkelbein, Jochen, Longrois, Dan, Popp, Maria, de Boer, Hans D., Sorbello, Massimiliano, Jankovic, Radmilo, and Kranke, Peter

Abstract

Recent data indicated a high incidence of inappropriate management of neuromuscular block, with a high rate of residual paralysis and relaxant-associated postoperative complications. These data are alarming in that the available neuromuscular monitoring, as well as myorelaxants and their antagonists basically allow well tolerated management of neuromuscular blockade. In this first European Society of Anaesthesiology and Intensive Care (ESAIC) guideline on peri-operative management of neuromuscular block, we aim to present aggregated and evidence-based recommendations to assist clinicians provide best medical care and ensure patient safety. We identified three main clinical questions: Are myorelaxants necessary to facilitate tracheal intubation in adults? Does the intensity of neuromuscular blockade influence a patient's outcome in abdominal surgery? What are the strategies for the diagnosis and treatment of residual paralysis? On the basis of this, PICO (patient, intervention, comparator, outcome) questions were derived that guided a structured literature search. A stepwise approach was used to reduce the number of trials of the initial research ( n = 24 000) to the finally relevant clinical studies ( n = 88). GRADE methodology (Grading of Recommendations, Assessment, Development and Evaluation) was used for formulating the recommendations based on the findings of the included studies in conjunction with their methodological quality. A two-step Delphi process was used to determine the agreement of the panel members with the recommendations: R1 We recommend using a muscle relaxant to facilitate tracheal intubation (1A). R2 We recommend the use of muscle relaxants to reduce pharyngeal and/or laryngeal injury following endotracheal intubation (1C). R3 We recommend the use of a fast-acting muscle relaxant for rapid sequence induction intubation (RSII) such as succinylcholine 1 mg kg −1 or rocuronium 0.9 to 1.2 mg kg −1 (1B). R4 We recommend deepening neuromuscular blo, info:eu-repo/semantics/published

Published
2023

22. Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery :An International Randomized Controlled Trial.

Author

Marcucci, Maura, Painter, Thomas TW, Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I, Chan, Matthew T V, Borges, Flavia K, Leslie, Kate, Duceppe, Emmanuelle, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N, Wang, Michael Ke, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo YV, Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X, Short, Timothy TG, Wittmann, Maria, Meyhoff, Christian Sylvest, Amir, Mohammed, Torres, David, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel JL, Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carísi Anne, Lamy, Andre, Jayaram, Raja, Astrakov, Sergey SV, Wu, William Ka Kei, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail M.Y., de Nadal, Miriam, Likhvantsev, Valery VV, Paniagua, Pilar, Aguado, Hector HJ, Maheshwari, Kamal, Whitlock, Richard RP, McGillion, Michael MH, Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce BM, Srinathan, Sadeesh, Ismoilov, Samandar, Pettit, Shirley, Stillo, David, Kurz, Andrea, Belley-Côté, Emilie EP, Spence, Jessica, McIntyre, William WF, Bangdiwala, Shrikant SI, Guyatt, Gordon, Yusuf, Salim, Devereaux, P J, POISE-3 Trial Investigators and Study Groups, Marcucci, Maura, Painter, Thomas TW, Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I, Chan, Matthew T V, Borges, Flavia K, Leslie, Kate, Duceppe, Emmanuelle, Martínez-Zapata, María José, Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N, Wang, Michael Ke, Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo YV, Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X, Short, Timothy TG, Wittmann, Maria, Meyhoff, Christian Sylvest, Amir, Mohammed, Torres, David, Patel, Ameen, Ruetzler, Kurt, Parlow, Joel JL, Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carísi Anne, Lamy, Andre, Jayaram, Raja, Astrakov, Sergey SV, Wu, William Ka Kei, Cheong, Chao Chia, Ayad, Sabry, Kirov, Mikhail M.Y., de Nadal, Miriam, Likhvantsev, Valery VV, Paniagua, Pilar, Aguado, Hector HJ, Maheshwari, Kamal, Whitlock, Richard RP, McGillion, Michael MH, Vincent, Jessica, Copland, Ingrid, Balasubramanian, Kumar, Biccard, Bruce BM, Srinathan, Sadeesh, Ismoilov, Samandar, Pettit, Shirley, Stillo, David, Kurz, Andrea, Belley-Côté, Emilie EP, Spence, Jessica, McIntyre, William WF, Bangdiwala, Shrikant SI, Guyatt, Gordon, Yusuf, Salim, Devereaux, P J, and POISE-3 Trial Investigators and Study Groups

Abstract

Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

24. Jet Ventilation Reduces Coronary Sinus Movement in Patients Undergoing Atrial Fibrillation Ablation: An Observational Crossover Study.

Author

Maeyens, Cecile, Nokerman, Pierre, Casado-Arroyo, Ruben, Abugattas De Torres, Juan Pablo, Alexander, Brenton, Engelman, Edgard, Schmartz, Denis, Tuna, Turgay, Maeyens, Cecile, Nokerman, Pierre, Casado-Arroyo, Ruben, Abugattas De Torres, Juan Pablo, Alexander, Brenton, Engelman, Edgard, Schmartz, Denis, and Tuna, Turgay

Abstract

One of the reasons that high-frequency jet ventilation (HFJV) is used is due to the near immobility of thoracic structures. However, no study has quantified the movements of cardiac structures during HFJV compared with normal mechanical ventilation., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

25. Peri-operative management of neuromuscular blockade:A guideline from the European Society of Anaesthesiology and Intensive Care

Author

Fuchs-Buder, Thomas, Romero, Carolina S., Lewald, Heidrun, Lamperti, Massimo, Afshari, Arash, Hristovska, Ana Marjia, Schmartz, Denis, Hinkelbein, Jochen, Longrois, Dan, Popp, Maria, De Boer, Hans D., Sorbello, Massimiliano, Jankovic, Radmilo, Kranke, Peter, Fuchs-Buder, Thomas, Romero, Carolina S., Lewald, Heidrun, Lamperti, Massimo, Afshari, Arash, Hristovska, Ana Marjia, Schmartz, Denis, Hinkelbein, Jochen, Longrois, Dan, Popp, Maria, De Boer, Hans D., Sorbello, Massimiliano, Jankovic, Radmilo, and Kranke, Peter

Abstract

Recent data indicated a high incidence of inappropriate management of neuromuscular block, with a high rate of residual paralysis and relaxant-associated postoperative complications. These data are alarming in that the available neuromuscular monitoring, as well as myorelaxants and their antagonists basically allow well tolerated management of neuromuscular blockade. In this first European Society of Anaesthesiology and Intensive Care (ESAIC) guideline on peri-operative management of neuromuscular block, we aim to present aggregated and evidence-based recommendations to assist clinicians provide best medical care and ensure patient safety. We identified three main clinical questions: Are myorelaxants necessary to facilitate tracheal intubation in adults? Does the intensity of neuromuscular blockade influence a patient's outcome in abdominal surgery? What are the strategies for the diagnosis and treatment of residual paralysis? On the basis of this, PICO (patient, intervention, comparator, outcome) questions were derived that guided a structured literature search. A stepwise approach was used to reduce the number of trials of the initial research (n = 24 000) to the finally relevant clinical studies (n = 88). GRADE methodology (Grading of Recommendations, Assessment, Development and Evaluation) was used for formulating the recommendations based on the findings of the included studies in conjunction with their methodological quality. A two-step Delphi process was used to determine the agreement of the panel members with the recommendations: R1 We recommend using a muscle relaxant to facilitate tracheal intubation (1A). R2 We recommend the use of muscle relaxants to reduce pharyngeal and/or laryngeal injury following endotracheal intubation (1C). R3 We recommend the use of a fast-acting muscle relaxant for rapid sequence induction intubation (RSII) such as succinylcholine 1 mg kg−1 or rocuronium 0.9 to 1.2 mg kg−1 (1B). R4 We recommend deepening neuromuscular blockade, Recent data indicated a high incidence of inappropriate management of neuromuscular block, with a high rate of residual paralysis and relaxant-associated postoperative complications. These data are alarming in that the available neuromuscular monitoring, as well as myorelaxants and their antagonists basically allow well tolerated management of neuromuscular blockade. In this first European Society of Anaesthesiology and Intensive Care (ESAIC) guideline on peri-operative management of neuromuscular block, we aim to present aggregated and evidence-based recommendations to assist clinicians provide best medical care and ensure patient safety. We identified three main clinical questions: Are myorelaxants necessary to facilitate tracheal intubation in adults? Does the intensity of neuromuscular blockade influence a patient's outcome in abdominal surgery? What are the strategies for the diagnosis and treatment of residual paralysis? On the basis of this, PICO (patient, intervention, comparator, outcome) questions were derived that guided a structured literature search. A stepwise approach was used to reduce the number of trials of the initial research (n = 24 000) to the finally relevant clinical studies (n = 88). GRADE methodology (Grading of Recommendations, Assessment, Development and Evaluation) was used for formulating the recommendations based on the findings of the included studies in conjunction with their methodological quality. A two-step Delphi process was used to determine the agreement of the panel members with the recommendations: R1 We recommend using a muscle relaxant to facilitate tracheal intubation (1A). R2 We recommend the use of muscle relaxants to reduce pharyngeal and/or laryngeal injury following endotracheal intubation (1C). R3 We recommend the use of a fast-acting muscle relaxant for rapid sequence induction intubation (RSII) such as succinylcholine 1 mg kg-1or rocuronium 0.9 to 1.2 mg kg-1(1B). R4 We recommend deepening

Published
2023

31. PERIOPERATIVE EXTRACORPOREAL MEMBRANE OXYGENATION IN LUNG TRANSPLANTATION : PREDICTIVE CRITERIA.

Author

Mchakkah, Salaheddine, Aouisse, Mehdi, Boudart, Céline, Schmartz, Denis, Turgay, Tuna, and Perrin, Laurent

Abstract

The use of perioperative ECMO in lung transplantation helps overcome the unforeseen hemodynamic and respiratory instabilities that may occur during this type of surgery. However, no clear criteria are defined to predict the necessity of its application. Being able to anticipate the necessity for perioperative ECMO could enhance patient management, by preemptively avoiding unplanned ECMO and its associated complications. Therefore, we aim to assess whether criteria derived from preoperative echocardiography and right heart catheterization can effectively predict the necessity for ECMO support during lung transplantation. A total of 102 lung transplantations (27% for Pulmonary Fibrosis, 50% for Chronic Obstructive Pulmonary Disease, 10% for Pulmonary arterial hypertension and 13% for Cystic Fibrosis), performed at our center between January 2016 and December 2022, were retrospectively analyzed. Preoperative echocardiographies were reviewed, and qualitative and quantitative criteria were collected, alongside data from pre/perioperative right heart catheterization. Out of the total, 21 lung transplantations were performed under ECMO at our center. Our findings reveal that qualitative criteria derived from echocardiography, such as the presence of Right Ventricular Dysfunction (RVD) or moderate Tricuspid Regurgitation (mTR) are highly associated with the need for perioperative ECMO. In addition, various echocardiographic parameters, including Right Ventricle End-Diastolic Diameter (RVEDD), Tricuspid Annular Plane Systolic Excursion (TAPSE), Pulmonary Velocity Acceleration Time (PVAT), as well as values from perioperative right heart catheterization, such as systolic pulmonary arterial pressure (PAPs) and mean pulmonary arterial pressure (PAPm), were observed to be significantly correlated with the requirement for perioperative ECMO. Using Youden index and logistic regression, we established optimal cut-off values for each of these variables, as well as odds ratios, as indicated in the following table. Our study showed that we could identify patients at risk for unplanned ECMO during lung transplantation using criteria derived from preoperative echocardiography and perioperative right heart catheterization. These at-risk patients could gain from a preventive approach which could involve, for example, a preemptive introduction of ECMO cannula guides. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Evaluation of the recruitment potential in cardiac surgery patients using the collection of pulmonary compliance and calculation of the R/I ratio. Preliminary study.

Author

Badas, Jenny Adriana Carvalho, Guembe, Jaime Franco, de la Flor, Celia Novials, Scadurra, Giulia Giovanna, Jaubert, Leonard, Schmartz, Denis, Turgay, Tuna, and Perrin, Laurent

Abstract

Cardiac surgery influences respiratory morbidity through multiple mechanisms. In our institution, the anesthesia team uses classic ventilation strategies: reduction of FiO2 and tidal volume, with PEEP and recruitment maneuvers. Their effectiveness is evaluated by continuous measurement of arterial oxygen saturation. But Peep is usually kept between 5 and 8 due to cardiac condition. Optimization of ventilation could still be possible. We postulate that this recruitment potential could be evaluated with the measurement of compliance and calculation of the R/I ratio (described the first time in 2020 by L.Chen & L.Brochard). ARDS Patients with a ratio >0.5 are candidates for optimization of ventilation parameters and new recruitment maneuvers. The primary endpoint is to evaluate the potential for alveolar recruitment, in patients undergoing cardiac surgery, at 2 times of the intervention (after intubation, and after cardiopulmonary bypass (CPB), by collecting the values of pulmonary compliance and the R/I ratio. The secondary endpoint is to determine if there are statistically significant differences, in terms of respiratory and hemodynamic parameters during and after recruitment. This is a prospective and observational study with agreement of our ethics committee. The 25 patients studied (Left ventricular ejection fraction above 40 %) are undergoing simple cardiac surgery (valve replacement, valve plasty or coronary artery bypass grafting). Patients' perioperative data were recorded, to evaluate the recruitment potential (Post-intubation, and post-CPB). The R/I ratio is measured with the single breath method describe by L. Chen: Peep is set at 12 mmHg during 3 min (= recruitment maneuver). "Abruptly releasing PEEP (from 12 to 5 cm H2O) increases expired volume: the difference between this volume and the volume predicted by compliance at low PEEP estimated the recruited volume by PEEP. This recruited volume divided by the effective pressure change gave the compliance of the recruited lung; the ratio of this compliance to the compliance at low PEEP gave the recruitment-to-inflation ratio". A low ratio indicate surdistension. Preliminary results show significant differences with improvement of compliance 10 min after recruitment. The median R/I was 1.58 ± 0.67 before CPB and, 1.15 ± 0.64 after CPB indicating a potential for recruitment. P/F values did not show a statistically significant increase, which could reflect good pulmonary vasoconstriction in pulmonary atelectasis. Pulmonary atelectasis aren't detectable with the ratio pO2/FiO2. Recruitment maneuvers, with moderate PEEP, are well tolerated in our patients, with a normal left ventricle (LV) ejection fraction. In conclusion R/I ratio highlights a potential for recruitment in our cardiac surgery patients. This test is hemodynamically well tolerated and could differentiate patients who are candidates for an increase in PEEP. A larger study is needed to confirm these results. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Peri-operative management of neuromuscular blockade

Author

Fuchs-Buder, Thomas, primary, Romero, Carolina S., additional, Lewald, Heidrun, additional, Lamperti, Massimo, additional, Afshari, Arash, additional, Hristovska, Ana-Marjia, additional, Schmartz, Denis, additional, Hinkelbein, Jochen, additional, Longrois, Dan, additional, Popp, Maria, additional, de Boer, Hans D., additional, Sorbello, Massimiliano, additional, Jankovic, Radmilo, additional, and Kranke, Peter, additional

Published
2022
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35. Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Devereaux, P.J., Marcucci, Maura, Painter, Thomas W., Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Martínez-Zapata, María J., Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N., Wang, Michael K., Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurt, Parlow, Joel L., Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carisi A., Lamy, Andre, Astrakov, Sergey V., Rao, Mangala, Wu, William K.K., Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Whitlock, Richard P., McGillion, Michael H., Prystajecky, Michael, Vincent, Jessica, Eikelboom, John, Copland, Ingrid, Balasubramanian, Kumar, Turan, Alparslan, Bangdiwala, Shrikant I., Stillo, David, Gross, Peter L., Cafaro, Teresa, Alfonsi, Pascal, Roshanov, Pavel S., Belley-Côté, Emilie P., Spence, Jessica, Richards, Toby, VanHelder, Tomas, McIntyre, William, Guyatt, Gordon, Yusuf, Salim, Leslie, Kate, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Devereaux, P.J., Marcucci, Maura, Painter, Thomas W., Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Martínez-Zapata, María J., Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N., Wang, Michael K., Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurt, Parlow, Joel L., Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carisi A., Lamy, Andre, Astrakov, Sergey V., Rao, Mangala, Wu, William K.K., Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Whitlock, Richard P., McGillion, Michael H., Prystajecky, Michael, Vincent, Jessica, Eikelboom, John, Copland, Ingrid, Balasubramanian, Kumar, Turan, Alparslan, Bangdiwala, Shrikant I., Stillo, David, Gross, Peter L., Cafaro, Teresa, Alfonsi, Pascal, Roshanov, Pavel S., Belley-Côté, Emilie P., Spence, Jessica, Richards, Toby, VanHelder, Tomas, McIntyre, William, Guyatt, Gordon, Yusuf, Salim, and Leslie, Kate

Abstract

BACKGROUND Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. METHODS We conducted a trial involving patients undergoing noncardiac surgery. Patients were randomly assigned to receive tranexamic acid (1-g intravenous bolus) or placebo at the start and end of surgery (reported here) and, with the use of a partial factorial design, a hypotension-avoidance or hypertension-avoidance strategy (not reported here). The primary efficacy outcome was life-threatening bleeding, major bleeding, or bleeding into a critical organ (composite bleeding outcome) at 30 days. The pri- mary safety outcome was myocardial injury after noncardiac surgery, nonhemor- rhagic stroke, peripheral arterial thrombosis, or symptomatic proximal venous thromboembolism (composite cardiovascular outcome) at 30 days. To establish the noninferiority of tranexamic acid to placebo for the composite cardiovascular out- come, the upper boundary of the one-sided 97.5% confidence interval for the hazard ratio had to be below 1.125, and the one-sided P value had to be less than 0.025. RESULTS A total of 9535 patients underwent randomization. A composite bleeding outcome event occurred in 433 of 4757 patients (9.1%) in the tranexamic acid group and in 561 of 4778 patients (11.7%) in the placebo group (hazard ratio, 0.76; 95% confi- dence interval [CI], 0.67 to 0.87; absolute difference, −2.6 percentage points; 95% CI, −3.8 to −1.4; two-sided P<0.001 for superiority). A composite cardiovascular outcome event occurred in 649 of 4581 patients (14.2%) in the tranexamic acid group and in 639 of 4601 patients (13.9%) in the placebo group (hazard ratio, 1.02; 95% CI, 0.92 to 1.14; upper boundary of the one-sided 97.5% CI, 1.14; absolute difference, 0.3 per- centage points; 95% CI, −1.1 to 1.7; one-sided P=0.04 for noninferiority). CONCLUSIONS Among patients undergoing noncardiac surgery, the incidence of the com

Published
2022

36. The use of virtual reality in children undergoing vascular access procedures: a systematic review and meta-analysis

Author

Saliba, Thomas, Schmartz, Denis, Fils, Jean François, Van Der Linden, Philippe, Saliba, Thomas, Schmartz, Denis, Fils, Jean François, and Van Der Linden, Philippe

Abstract

Venous access procedures are painful and feared by children and their parents. Virtual reality has become increasingly prominent and has been shown to be effective in various procedures. The aim of this meta-analysis was to examine virtual reality’s effect on pain and fear in children from 4 to 12 in the context of vascular access. From the 20th to the 26th December 2020, we searched Sciencedirect, Springerlink, CENTRAL, Pubmed and PMC. Studies using virtual reality versus a control in vascular access for children were included in a meta-analysis to evaluate the effect of virtual reality regarding pain as a primary and fear/anxiety as a secondary endpoint during the procedures. The Jadad scale and Delphi List were used to assess study quality. 20,894 citations were identified, 9 met our inclusion criteria. One publication was conducted in two different situations and was thus considered as 2 studies. Compared to standard of care, virtual reality significantly reduced pain (10 studies, 930 participants: standardized mean difference [SMD] 2.54, 95%CI 0.14–4.93, p = 0.038), and fear/anxiety (6 studies, 648 participants: SMD 0.89, 95%Cl 0.16–1.63, p = 0.017). For both parameters, we found significant heterogeneity between studies. This is the first meta-analysis to look at the use virtual reality in young children undergoing vascular access procedures, providing weak to moderate evidence for its use. Although large effect sizes provide evidence for a positive effect of virtual reality in reducing pain and fear, there is significant heterogeneity between studies. More research with larger groups and age stratification is required., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

38. Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury:A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial

Author

Garg, Amit X., Cuerden, Meaghan, Aguado, Hector, Amir, Mohammed, Belley-Cote, Emilie P, Bhatt, Keyur, Biccard, Bruce M., Borges, Flavia K., Chan, Matthew, Conen, David, Duceppe, Emmanuelle, Efremov, Sergey, Eikelboom, John, Fleischmann, Edith, Giovanni, Landoni, Gross, Peter, Jayaram, Raja, Kirov, Mikhail, Kleinlugtenbelt, Ydo, Kurz, Andrea, Lamy, Andre, Leslie, Kate, Likhvantsev, Valery, Lomivorotov, Vladimir, Marcucci, Maura, Martínez-Zapata, Maria José, McGillion, Michael, McIntyre, William, Meyhoff, Christian, Ofori, Sandra, Painter, Thomas, Paniagua, Pilar, Parikh, Chirag, Parlow, Joel, Patel, Ameen, Polanczyk, Carisi, Richards, Toby, Roshanov, Pavel, Schmartz, Denis, Sessler, Daniel, Short, Tim, Sontrop, Jessica M., Spence, Jessica, Srinathan, Sadeesh, Stillo, David, Szczeklik, Wojciech, Tandon, Vikas, Torres, David, Van Helder, Thomas, Vincent, Jessica, Wang, C. Y., Wang, Michael, Whitlock, Richard, Wittmann, Maria, Xavier, Denis, Devereaux, P. J., Garg, Amit X., Cuerden, Meaghan, Aguado, Hector, Amir, Mohammed, Belley-Cote, Emilie P, Bhatt, Keyur, Biccard, Bruce M., Borges, Flavia K., Chan, Matthew, Conen, David, Duceppe, Emmanuelle, Efremov, Sergey, Eikelboom, John, Fleischmann, Edith, Giovanni, Landoni, Gross, Peter, Jayaram, Raja, Kirov, Mikhail, Kleinlugtenbelt, Ydo, Kurz, Andrea, Lamy, Andre, Leslie, Kate, Likhvantsev, Valery, Lomivorotov, Vladimir, Marcucci, Maura, Martínez-Zapata, Maria José, McGillion, Michael, McIntyre, William, Meyhoff, Christian, Ofori, Sandra, Painter, Thomas, Paniagua, Pilar, Parikh, Chirag, Parlow, Joel, Patel, Ameen, Polanczyk, Carisi, Richards, Toby, Roshanov, Pavel, Schmartz, Denis, Sessler, Daniel, Short, Tim, Sontrop, Jessica M., Spence, Jessica, Srinathan, Sadeesh, Stillo, David, Szczeklik, Wojciech, Tandon, Vikas, Torres, David, Van Helder, Thomas, Vincent, Jessica, Wang, C. Y., Wang, Michael, Whitlock, Richard, Wittmann, Maria, Xavier, Denis, and Devereaux, P. J.

Abstract

Background: Most patients who take antihypertensive medications continue taking them on the morning of surgery and during the perioperative period. However, growing evidence suggests this practice may contribute to perioperative hypotension and a higher risk of complications. This protocol describes an acute kidney injury substudy of the Perioperative Ischemic Evaluation-3 (POISE-3) trial, which is testing the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy in patients undergoing noncardiac surgery. Objective: To conduct a substudy of POISE-3 to determine whether a perioperative hypotension-avoidance strategy reduces the risk of acute kidney injury compared with a hypertension-avoidance strategy. Design: Randomized clinical trial with 1:1 randomization to the intervention (a perioperative hypotension-avoidance strategy) or control (a hypertension-avoidance strategy). Intervention: If the presurgery systolic blood pressure (SBP) is <130 mmHg, all antihypertensive medications are withheld on the morning of surgery. If the SBP is ≥130 mmHg, some medications (but not angiotensin receptor blockers [ACEIs], angiotensin receptor blockers [ARBs], or renin inhibitors) may be continued in a stepwise manner. During surgery, the patients’ mean arterial pressure (MAP) is maintained at ≥80 mmHg. During the first 48 hours after surgery, some antihypertensive medications (but not ACEIs, ARBs, or renin inhibitors) may be restarted in a stepwise manner if the SBP is ≥130 mmHg. Control: Patients receive their usual antihypertensive medications before and after surgery. The patients’ MAP is maintained at ≥60 mmHg from anesthetic induction until the end of surgery. Setting: Recruitment from 108 centers in 22 countries from 2018 to 2021. Patients: Patients (~6800) aged ≥45 years having noncardiac surgery who have or are at risk of atherosclerotic disease and who routinely take antihypertensive medications. Measurements: The primary

Published
2022

39. Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3):a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T.V., Borges, Flavia K., Martínez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K.K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, Devereaux, P. J., Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T.V., Borges, Flavia K., Martínez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K.K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Abstract

Background: For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to reduce surgical bleeding; however, there is uncertainty about its efficacy and safety in noncardiac surgery. Although usual perioperative care is commonly consistent with a hypertension-avoidance strategy (i.e., most patients continue their antihypertensive medications throughout the perioperative period and intraoperative mean arterial pressures of 60 mmHg are commonly accepted), a hypotension-avoidance strategy may improve perioperative outcomes. Methods: The PeriOperative Ischemic Evaluation (POISE)-3 Trial is a large international randomized controlled trial designed to determine if TXA is superior to placebo for the composite outcome of life-threatening, major, and critical organ bleeding, and non-inferior to placebo for the occurrence of major arterial and venous thrombotic events, at 30 days after randomization. Using a partial factorial design, POISE-3 will additionally determine the effect of a hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of major cardiovascular events, at 30 days after randomization. The target sample size is 10,000 participants. Patients ≥45 years of age undergoing noncardiac surgery, with or at risk of cardiovascular and bleeding complications, are randomized to receive a TXA 1 g intravenous bolus or matching placebo at the start and at the end of surgery. Patients, health care providers, data collectors, outcome adjudicators, and investigators are blinded to the treatment allocation. Patients on ≥ 1 chronic antihypertensive medication are also randomized to either of the two blood pressure management strategies, which differ in the management of patient antihypertensive medications on the morning of surgery and on the first 2 days after surgery, and in the ta

Published
2022

40. Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Author

Devereaux, P.J., primary, Marcucci, Maura, additional, Painter, Thomas W., additional, Conen, David, additional, Lomivorotov, Vladimir, additional, Sessler, Daniel I., additional, Chan, Matthew T.V., additional, Borges, Flavia K., additional, Martínez-Zapata, María J., additional, Wang, Chew Yin, additional, Xavier, Denis, additional, Ofori, Sandra N., additional, Wang, Michael K., additional, Efremov, Sergey, additional, Landoni, Giovanni, additional, Kleinlugtenbelt, Ydo V., additional, Szczeklik, Wojciech, additional, Schmartz, Denis, additional, Garg, Amit X., additional, Short, Timothy G., additional, Wittmann, Maria, additional, Meyhoff, Christian S., additional, Amir, Mohammed, additional, Torres, David, additional, Patel, Ameen, additional, Duceppe, Emmanuelle, additional, Ruetzler, Kurt, additional, Parlow, Joel L., additional, Tandon, Vikas, additional, Fleischmann, Edith, additional, Polanczyk, Carisi A., additional, Lamy, Andre, additional, Astrakov, Sergey V., additional, Rao, Mangala, additional, Wu, William K.K., additional, Bhatt, Keyur, additional, de Nadal, Miriam, additional, Likhvantsev, Valery V., additional, Paniagua, Pilar, additional, Aguado, Hector J., additional, Whitlock, Richard P., additional, McGillion, Michael H., additional, Prystajecky, Michael, additional, Vincent, Jessica, additional, Eikelboom, John, additional, Copland, Ingrid, additional, Balasubramanian, Kumar, additional, Turan, Alparslan, additional, Bangdiwala, Shrikant I., additional, Stillo, David, additional, Gross, Peter L., additional, Cafaro, Teresa, additional, Alfonsi, Pascal, additional, Roshanov, Pavel S., additional, Belley-Côté, Emilie P., additional, Spence, Jessica, additional, Richards, Toby, additional, VanHelder, Tomas, additional, McIntyre, William, additional, Guyatt, Gordon, additional, Yusuf, Salim, additional, and Leslie, Kate, additional

Published
2022
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43. Additional file 9 of Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Mart��nez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Abstract

Additional file 9. POISE-3 informed consent form template (English).

Published
2022
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44. Additional file 7 of Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Mart��nez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Abstract

Additional file 7. POISE-3 interim analyses.

Published
2022
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45. Additional file 10 of Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Mart��nez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, Data_FILES, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Additional file 10. List of investigators and committees.

Published
2022
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46. Additional file 8 of Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Mart��nez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Abstract

Additional file 8. POISE-3 organizational structure and oversight of trial conduct.

Published
2022
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47. Additional file 5 of Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Mart��nez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Abstract

Additional file 5. POISE-3 tertiary outcomes.

Published
2022
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48. sj-docx-1-cjk-10.1177_20543581211069225 ��� Supplemental material for Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial

Author

Garg, Amit X., Cuerden, Meaghan, Aguado, Hector, Amir, Mohammed, Belley-Cote, Emilie P., Bhatt, Keyur, Biccard, Bruce M., Borges, Flavia K., Chan, Matthew, Conen, David, Duceppe, Emmanuelle, Efremov, Sergey, Eikelboom, John, Fleischmann, Edith, Giovanni, Landoni, Gross, Peter, Jayaram, Raja, Kirov, Mikhail, Kleinlugtenbelt, Ydo, Kurz, Andrea, Lamy, Andre, Leslie, Kate, Likhvantsev, Valery, Lomivorotov, Vladimir, Marcucci, Maura, Mart��nez-Zapata, Maria Jos��, McGillion, Michael, McIntyre, William, Meyhoff, Christian, Ofori, Sandra, Painter, Thomas, Paniagua, Pilar, Parikh, Chirag, Parlow, Joel, Patel, Ameen, Polanczyk, Carisi, Richards, Toby, Roshanov, Pavel, Schmartz, Denis, Sessler, Daniel, Short, Tim, Sontrop, Jessica M., Spence, Jessica, Srinathan, Sadeesh, Stillo, David, Szczeklik, Wojciech, Tandon, Vikas, Torres, David, Van Helder, Thomas, Vincent, Jessica, Wang, C. Y., Wang, Michael, Whitlock, Richard, Wittmann, Maria, Xavier, Denis, and Devereaux, P. J.

Subjects
Medicine
Abstract

Supplemental material, sj-docx-1-cjk-10.1177_20543581211069225 for Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial by Amit X. Garg, Meaghan Cuerden, Hector Aguado, Mohammed Amir, Emilie P. Belley-Cote, Keyur Bhatt, Bruce M. Biccard, Flavia K. Borges, Matthew Chan, David Conen, Emmanuelle Duceppe, Sergey Efremov, John Eikelboom, Edith Fleischmann, Landoni Giovanni, Peter Gross, Raja Jayaram, Mikhail Kirov, Ydo Kleinlugtenbelt, Andrea Kurz, Andre Lamy, Kate Leslie, Valery Likhvantsev, Vladimir Lomivorotov, Maura Marcucci, Maria Jos�� Mart��nez-Zapata, Michael McGillion, William McIntyre, Christian Meyhoff, Sandra Ofori, Thomas Painter, Pilar Paniagua, Chirag Parikh, Joel Parlow, Ameen Patel, Carisi Polanczyk, Toby Richards, Pavel Roshanov, Denis Schmartz, Daniel Sessler, Tim Short, Jessica M. Sontrop, Jessica Spence, Sadeesh Srinathan, David Stillo, Wojciech Szczeklik, Vikas Tandon, David Torres, Thomas Van Helder, Jessica Vincent, C. Y. Wang, Michael Wang, Richard Whitlock, Maria Wittmann, Denis Xavier and P. J. Devereaux in Canadian Journal of Kidney Health and Disease

Published
2022
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49. Additional file 3 of Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Mart��nez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Abstract

Additional file 3. Rationale for POISE-3 study dosing regimen of tranexamic acid.

Published
2022
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50. Additional file 6 of Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Author

Marcucci, Maura, Painter, Thomas W., Conen, David, Leslie, Kate, Lomivorotov, Vladimir V., Sessler, Daniel, Chan, Matthew T. V., Borges, Flavia K., Mart��nez Zapata, Maria J., Wang, C. Y., Xavier, Denis, Ofori, Sandra N., Landoni, Giovanni, Efremov, Sergey, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurtz, Parlow, Joel L., Tandon, Vikas, Wang, Michael K., Fleischmann, Edith, Polanczyk, Carisi A., Jayaram, Raja, Astrakov, Sergey V., Rao, Mangala, VanHelder, Tomas, Wu, William K. K., Cheong, Chao Chia, Ayad, Sabry, Abubakirov, Marat, Kirov, Mikhail, Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery, Iglesisas, Pilar Paniagua, Aguado, Hector J., McGillion, Michael, Lamy, Andre, Whitlock, Richard P., Roshanov, Pavel, Stillo, David, Copland, Ingrid, Vincent, Jessica, Balasubramanian, Kumar, Bangdiwala, Shrikant I., Biccard, Bruce, Kurz, Andrea, Srinathan, Sadeesh, Petit, Shirley, Eikelboom, John, Richards, Toby, Gross, Peter L., Alfonsi, Pascal, Guyatt, Gordon, Belley-Cote, Emily, Spence, Jessica, McIntyre, William, Yusuf, Salim, and Devereaux, P. J.

Abstract

Additional file 6. POISE-3 outcome definitions.

Published
2022
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