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Your search keyword '"Schmäche, Tim"' showing total 9 results
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9 results on '"Schmäche, Tim"'

1. Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold

Author

Schmäche, Tim, Fohgrub, Juliane, Klimova, Anna, Laaber, Karin, Drukewitz, Stephan, Merboth, Felix, Hennig, Alexander, Seidlitz, Therese, Herbst, Friederike, Baenke, Franziska, Ada, Anne-Marlen, Groß, Thomas, Wenzel, Carina, Ball, Claudia R., Praetorius, Christian, Schmidt, Thomas, Ringelband-Schilling, Barbara, Koschny, Ronald, Stenzinger, Albrecht, Roeder, Ingo, Jaeger, Dirk, Zeissig, Sebastian, Welsch, Thilo, Aust, Daniela, Glimm, Hanno, Folprecht, Gunnar, Weitz, Jürgen, Haag, Georg M., and Stange, Daniel E.

Published
2024
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3. CRISPR/Cas9 Screen in Gastric Cancer Patient‐Derived Organoids Reveals KDM1A‐NDRG1 Axis as a Targetable Vulnerability

Author

Mircetic, Jovan, primary, Camgöz, Aylin, additional, Abohawya, Moustafa, additional, Ding, Li, additional, Dietzel, Julia, additional, Tobar, Sebastián García, additional, Paszkowski‐Rogacz, Maciej, additional, Seidlitz, Therese, additional, Schmäche, Tim, additional, Mehnert, Marie‐Christin, additional, Sidorova, Olga, additional, Weitz, Jürgen, additional, Buchholz, Frank, additional, and Stange, Daniel E., additional

Published
2023
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4. Acquired epithelial WNT secretion drives niche independence of developing gastric cancer

Author

Teriyapirom, Isaree, primary, Kim, Jihoon, additional, Lee, Heetak, additional, Merker, Sebastian R., additional, Andersson-Rolf, Amanda, additional, Jahn, Stephan R., additional, Ada, Anne-Marlen, additional, Kim, Sang-Min, additional, Lim, Joo Yeon, additional, Schmäche, Tim, additional, Wetterling, Nancy, additional, Stegert, Saskia, additional, Park, Ji-Yeon, additional, Cheong, Jae-Ho, additional, Kim, Hyunki, additional, Stange, Daniel E., additional, and Koo, Bon-Kyoung, additional

Published
2023
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5. Sensitization of Patient-Derived Colorectal Cancer Organoids to Photon and Proton Radiation by Targeting DNA Damage Response Mechanisms

Author

Pape, Kristin, primary, Lößner, Anna J., additional, William, Doreen, additional, Czempiel, Tabea, additional, Beyreuther, Elke, additional, Klimova, Anna, additional, Lehmann, Claudia, additional, Schmäche, Tim, additional, Merker, Sebastian R., additional, Naumann, Max, additional, Ada, Anne-Marlen, additional, Baenke, Franziska, additional, Seidlitz, Therese, additional, Bütof, Rebecca, additional, Dietrich, Antje, additional, Krause, Mechthild, additional, Weitz, Jürgen, additional, Klink, Barbara, additional, von Neubeck, Cläre, additional, and Stange, Daniel E., additional

Published
2022
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6. Sensitivity towards HDAC inhibition is associated with RTK / MAPK pathway activation in gastric cancer

Author

Seidlitz, Therese, primary, Schmäche, Tim, additional, Garcίa, Fernando, additional, Lee, Joon Ho, additional, Qin, Nan, additional, Kochall, Susan, additional, Fohgrub, Juliane, additional, Pauck, David, additional, Rothe, Alexander, additional, Koo, Bon‐Kyoung, additional, Weitz, Jürgen, additional, Remke, Marc, additional, Muñoz, Javier, additional, and Stange, Daniel E, additional

Published
2022
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7. Detecting drug resistance in pancreatic cancer organoids guides optimized chemotherapy treatment

Author

Hennig, Alexander, Baenke, Franziska, Klimova, Anna, Drukewitz, Stephan, Jahnke, Beatrix, Brückmann, Sascha, Secci, Ramona, Winter, Christof, Schmäche, Tim, Seidlitz, Therese, Bereuter, Jean-Paul, Polster, Heike, Eckhardt, Lisa, Schneider, Sidney A, Brückner, Stefan, Schmelz, Renate, Babatz, Jana, Kahlert, Christoph, Distler, Marius, Hampe, Jochen, Reichert, Maximiliam, Zeißig, Sebastian, Folprecht, Gunnar, Weitz, Jürgen, Aust, Daniela, Welsch, Thilo, Stange, Daniel E, Hennig, Alexander, Baenke, Franziska, Klimova, Anna, Drukewitz, Stephan, Jahnke, Beatrix, Brückmann, Sascha, Secci, Ramona, Winter, Christof, Schmäche, Tim, Seidlitz, Therese, Bereuter, Jean-Paul, Polster, Heike, Eckhardt, Lisa, Schneider, Sidney A, Brückner, Stefan, Schmelz, Renate, Babatz, Jana, Kahlert, Christoph, Distler, Marius, Hampe, Jochen, Reichert, Maximiliam, Zeißig, Sebastian, Folprecht, Gunnar, Weitz, Jürgen, Aust, Daniela, Welsch, Thilo, and Stange, Daniel E

Abstract

Drug combination therapies for cancer treatment show high efficacy but often induce severe side effects, resulting in dose or cycle number reduction. We investigated the impact of neoadjuvant chemotherapy (neoCTx) adaptions on treatment outcome in 59 patients with pancreatic ductal adenocarcinoma (PDAC). Resections with tumor-free margins were significantly more frequent when full-dose neoCTx was applied. We determined if patient-derived organoids (PDOs) can be used to personalize poly-chemotherapy regimens by pharmacotyping of treatment-naïve and post-neoCTx PDAC PDOs. Five out of ten CTx-naïve PDO lines exhibited a differential response to either the FOLFIRINOX or the Gem/Pac regimen. NeoCTx PDOs showed a poor response to the neoadjuvant regimen that had been administered to the respective patient in 30% of cases. No significant difference in PDO response was noted when comparing modified treatments in which the least effective single drug was removed from the complete regimen.Drug testing of CTx-naïve PDAC PDOs and neoCTx PDOs may be useful to guide neoadjuvant and adjuvant regimen selection, respectively. Personalizing poly-chemotherapy regimens by omitting substances with low efficacy could potentially result in less severe side effects, thereby increasing the fraction of patients receiving a full course of neoadjuvant treatment.

Published
2022

8. Detecting drug resistance in pancreatic cancer organoids guides optimized chemotherapy treatment

Author

Hennig, Alexander, primary, Baenke, Franziska, additional, Klimova, Anna, additional, Drukewitz, Stephan, additional, Jahnke, Beatrix, additional, Brückmann, Sascha, additional, Secci, Ramona, additional, Winter, Christof, additional, Schmäche, Tim, additional, Seidlitz, Therese, additional, Bereuter, Jean‐Paul, additional, Polster, Heike, additional, Eckhardt, Lisa, additional, Schneider, Sidney A, additional, Brückner, Stefan, additional, Schmelz, Renate, additional, Babatz, Jana, additional, Kahlert, Christoph, additional, Distler, Marius, additional, Hampe, Jochen, additional, Reichert, Maximilian, additional, Zeißig, Sebastian, additional, Folprecht, Gunnar, additional, Weitz, Jürgen, additional, Aust, Daniela, additional, Welsch, Thilo, additional, and Stange, Daniel E, additional

Published
2022
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9. A Novel Splice Variant of the Inhibitor of Growth 3 Lacks the Plant Homeodomain and Regulates Epithelial–Mesenchymal Transition in Prostate Cancer Cells

Author

Melekhova, Anna, primary, Leeder, Mirjam, additional, Pungsrinont, Thanakorn, additional, Schmäche, Tim, additional, Kallenbach, Julia, additional, Ehsani, Marzieh, additional, Mirzakhani, Kimia, additional, Rasa, Seyed Mohammad Mahdi, additional, Neri, Francesco, additional, and Baniahmad, Aria, additional

Published
2021
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