Search

Your search keyword '"Schlederer, Thomas"' showing total 34 results
Start Over Author "Schlederer, Thomas"
34 results on '"Schlederer, Thomas"'

2. Toward personalization of asthma treatment according to trigger factors

Author

Niespodziana, Katarzyna, Borochova, Kristina, Pazderova, Petra, Schlederer, Thomas, Astafyeva, Natalia, Baranovskaya, Tatiana, Barbouche, Mohamed-Ridha, Beltyukov, Evgeny, Berger, Angelika, Borzova, Elena, Bousquet, Jean, Bumbacea, Roxana S., Bychkovskaya, Snezhana, Caraballo, Luis, Chung, Kian Fan, Custovic, Adnan, Docena, Guillermo, Eiwegger, Thomas, Evsegneeva, Irina, Emelyanov, Alexander, Errhalt, Peter, Fassakhov, Rustem, Fayzullina, Rezeda, Fedenko, Elena, Fomina, Daria, Gao, Zhongshan, Giavina-Bianchi, Pedro, Gotua, Maia, Greber-Platzer, Susanne, Hedlin, Gunilla, Ilina, Natalia, Ispayeva, Zhanat, Idzko, Marco, Johnston, Sebastian L., Kalayci, Ömer, Karaulov, Alexander, Karsonova, Antonina, Khaitov, Musa, Kovzel, Elena, Kowalski, Marek L., Kudlay, Dmitry, Levin, Michael, Makarova, Svetlana, Matricardi, Paolo Maria, Nadeau, Kari C., Namazova-Baranova, Leyla, Naumova, Olga, Nazarenko, Oleksandr, O’Byrne, Paul M., Osier, Faith, Pampura, Alexander N., Panaitescu, Carmen, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pohl, Wolfgang, Renz, Harald, Riabova, Ksenja, Sampath, Vanitha, Sekerel, Bülent E., Sibanda, Elopy, Siroux, Valérie, Sizyakina, Ludmila P., Sun, Jin-Lyu, Szepfalusi, Zsolt, Umanets, Tetiana, Van Bever, Hugo P.S., van Hage, Marianne, Vasileva, Margarita, von Mutius, Erika, Wang, Jiu-Yao, Wong, Gary W.K., Zaikov, Sergii, Zidarn, Mihaela, and Valenta, Rudolf

Published
2020
Full Text
View/download PDF

3. Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults

Author

Guillien, Alicia, primary, Niespodziana, Katarzyna, additional, Mauclin, Marion, additional, Boudier, Anne, additional, Varraso, Raphäelle, additional, Leynaert, Bénédicte, additional, Dumas, Orianne, additional, Le Moual, Nicole, additional, Schlederer, Thomas, additional, Bajic, Maja, additional, Borochova, Kristina, additional, Errhalt, Peter, additional, Vernet, Raphaël, additional, Nadif, Rachel, additional, Bousquet, Jean, additional, Bouzigon, Emmanuelle, additional, Valenta, Rudolf, additional, and Siroux, Valérie, additional

Published
2024
Full Text
View/download PDF

4. Rhinovirus specific IgG responses and respiratory health in children and adults of the EGEA cohort

Author

Mauclin, Marion, primary, Guillien, Alicia, additional, Niespodziana, Katarzyna, additional, Boudier, Anne, additional, Schlederer, Thomas, additional, Bajic, Maja, additional, Vernet, Raphaël, additional, Nadif, Rachel, additional, Bousquet, Jean, additional, Bouzigon, Emmanuelle, additional, Valenta, Rudolf, additional, and Siroux, Valérie, additional

Published
2023
Full Text
View/download PDF

5. Milk Allergen Micro-Array (MAMA) for Refined Detection of Cow’s-Milk-Specific IgE Sensitization

Author

Garib, Victoria, primary, Trifonova, Daria, additional, Freidl, Raphaela, additional, Linhart, Birgit, additional, Schlederer, Thomas, additional, Douladiris, Nikolaos, additional, Pampura, Alexander, additional, Dolotova, Daria, additional, Lepeshkova, Tatiana, additional, Gotua, Maia, additional, Varlamov, Evgeniy, additional, Beltyukov, Evgeny, additional, Naumova, Veronika, additional, Taka, Styliani, additional, Kiyamova, Alina, additional, Katsamaki, Stefani, additional, Karaulov, Alexander, additional, and Valenta, Rudolf, additional

Published
2023
Full Text
View/download PDF

6. Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

Author

Lupinek, Christian, Wollmann, Eva, Baar, Alexandra, Banerjee, Srinita, Breiteneder, Heimo, Broecker, Barbara M., Bublin, Merima, Curin, Mirela, Flicker, Sabine, Garmatiuk, Tetiana, Hochwallner, Heidrun, Mittermann, Irene, Pahr, Sandra, Resch, Yvonne, Roux, Kenneth H., Srinivasan, Bharani, Stentzel, Sebastian, Vrtala, Susanne, Willison, LeAnna N., Wickman, Magnus, Lødrup-Carlsen, Karin C., Antó, Josep Maria, Bousquet, Jean, Bachert, Claus, Ebner, Daniel, Schlederer, Thomas, Harwanegg, Christian, and Valenta, Rudolf

Published
2014
Full Text
View/download PDF

7. Microarray-Based Analyses of Rhinovirus Species-Specific Antibody Responses in Exacerbated Pediatric Asthma in a German Pediatric Cohort

Author

Sallard, Erwan, primary, Niespodziana, Katarzyna, additional, Bajic, Maja, additional, Schlederer, Thomas, additional, Errhalt, Peter, additional, Behrendt, Ann-Kathrin, additional, Wirth, Stefan, additional, Meyer-Bahlburg, Almut, additional, Ehrhardt, Anja, additional, Valenta, Rudolf, additional, and Aydin, Malik, additional

Published
2022
Full Text
View/download PDF

8. Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes

Author

Gattinger, Pia, Niespodziana, Katarzyna, Stiasny, Karin, Sahanic, Sabina, Tulaeva, Inna, Borochova, Kristina, Dorofeeva, Yulia, Schlederer, Thomas, Sonnweber, Thomas, Hofer, Gerhard, Kiss, Renata, Kratzer, Bernhard, Trapin, Doris, Tauber, Peter A., Rottal, Arno, Körmöczi, Ulrike, Feichter, Melanie, Weber, Milena, Focke-Tejkl, Margarete, Löffler-Ragg, Judith, Mühl, Bernhard, Kropfmüller, Anna, Keller, Walter, Stolz, Frank, Henning, Rainer, Tancevski, Ivan, Puchhammer-Stöckl, Elisabeth, Pickl, Winfried F., Valenta, Rudolf, Gattinger, Pia, Niespodziana, Katarzyna, Stiasny, Karin, Sahanic, Sabina, Tulaeva, Inna, Borochova, Kristina, Dorofeeva, Yulia, Schlederer, Thomas, Sonnweber, Thomas, Hofer, Gerhard, Kiss, Renata, Kratzer, Bernhard, Trapin, Doris, Tauber, Peter A., Rottal, Arno, Körmöczi, Ulrike, Feichter, Melanie, Weber, Milena, Focke-Tejkl, Margarete, Löffler-Ragg, Judith, Mühl, Bernhard, Kropfmüller, Anna, Keller, Walter, Stolz, Frank, Henning, Rainer, Tancevski, Ivan, Puchhammer-Stöckl, Elisabeth, Pickl, Winfried F., and Valenta, Rudolf

Abstract

Background: The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important. Methods: In this study, we analyzed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus. Results: S- and RBD-specific antibody responses were dominated by immunoglobulin G (IgG), mainly IgG1, and directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunization with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants. Conclusion: These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2–neutralizing antibodies conferring sterilizing immunity.

Published
2022
Full Text
View/download PDF

9. Molecular reactivity profiling upon immunotherapy with a 300 IR sublingual house dust mite tablet reveals marked humoral changes towards major allergens

Author

Potapova, Ekaterina, primary, Bordas‐Le Floch, Véronique, additional, Schlederer, Thomas, additional, Vrtala, Susanne, additional, Huang, Huey‐Jy, additional, Canonica, Giorgio W., additional, Valenta, Rudolf, additional, Matricardi, Paolo M., additional, and Mascarell, Laurent, additional

Published
2022
Full Text
View/download PDF

10. Characterization of the antibody response to SARS‐CoV‐2 in a mildly affected pediatric population

Author

Kopanja, Sonja, primary, Gattinger, Pia, additional, Schmidthaler, Klara, additional, Sieber, Justyna, additional, Niepodziana, Katarzyna, additional, Schlederer, Thomas, additional, Weseslindtner, Lukas, additional, Stiasny, Karin, additional, Götzinger, Florian, additional, Pickl, Winfried F., additional, Frischer, Thomas, additional, Valenta, Rudolf, additional, and Szépfalusi, Zsolt, additional

Published
2022
Full Text
View/download PDF

11. Neutralization of SARS‐CoV‐2 requires antibodies against conformational receptor‐binding domain epitopes

Author

Gattinger, Pia, primary, Niespodziana, Katarzyna, additional, Stiasny, Karin, additional, Sahanic, Sabina, additional, Tulaeva, Inna, additional, Borochova, Kristina, additional, Dorofeeva, Yulia, additional, Schlederer, Thomas, additional, Sonnweber, Thomas, additional, Hofer, Gerhard, additional, Kiss, Renata, additional, Kratzer, Bernhard, additional, Trapin, Doris, additional, Tauber, Peter A., additional, Rottal, Arno, additional, Körmöczi, Ulrike, additional, Feichter, Melanie, additional, Weber, Milena, additional, Focke‐Tejkl, Margarete, additional, Löffler‐Ragg, Judith, additional, Mühl, Bernhard, additional, Kropfmüller, Anna, additional, Keller, Walter, additional, Stolz, Frank, additional, Henning, Rainer, additional, Tancevski, Ivan, additional, Puchhammer‐Stöckl, Elisabeth, additional, Pickl, Winfried F., additional, and Valenta, Rudolf, additional

Published
2021
Full Text
View/download PDF

13. Microarray-Based Allergy Diagnosis: Quo Vadis?

Author

Huang, Huey-Jy, primary, Campana, Raffaela, additional, Akinfenwa, Oluwatoyin, additional, Curin, Mirela, additional, Sarzsinszky, Eszter, additional, Karsonova, Antonina, additional, Riabova, Ksenja, additional, Karaulov, Alexander, additional, Niespodziana, Katarzyna, additional, Elisyutina, Olga, additional, Fedenko, Elena, additional, Litovkina, Alla, additional, Smolnikov, Evgenii, additional, Khaitov, Musa, additional, Vrtala, Susanne, additional, Schlederer, Thomas, additional, and Valenta, Rudolf, additional

Published
2021
Full Text
View/download PDF

15. PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze

Author

Niespodziana, Katarzyna, primary, Stenberg-Hammar, Katarina, additional, Megremis, Spyridon, additional, Cabauatan, Clarissa R., additional, Napora-Wijata, Kamila, additional, Vacal, Phyllis C., additional, Gallerano, Daniela, additional, Lupinek, Christian, additional, Ebner, Daniel, additional, Schlederer, Thomas, additional, Harwanegg, Christian, additional, Söderhäll, Cilla, additional, van Hage, Marianne, additional, Hedlin, Gunilla, additional, Papadopoulos, Nikolaos G., additional, and Valenta, Rudolf, additional

Published
2018
Full Text
View/download PDF

16. HIV microarray for the mapping and characterization of HIV-specific antibody responses

Author

Gallerano, Daniela, Wollmann, Eva, Lupinek, Christian, Schlederer, Thomas, Ebner, Daniel, Harwanegg, Christian, Niespodziana, Katarzyna, Schmetterer, Klaus, Pickl, Winfried, Puchhammer Stöckl, Elisabeth, Sibanda, Elopy, and Valenta, Rudolf

Subjects
epitope, human immunodeficiency virus antigen, human immunodeficiency virus antibody
Published
2015

18. Correction: HIV microarray for the mapping and characterization of HIV-specific antibody responses

Author

Gallerano, Daniela, primary, Wollmann, Eva, additional, Lupinek, Christian, additional, Schlederer, Thomas, additional, Ebner, Daniel, additional, Harwanegg, Christian, additional, Niespodziana, Katarzyna, additional, Schmetterer, Klaus, additional, Pickl, Winfried, additional, Puchhammer-Stöckl, Elisabeth, additional, Sibanda, Elopy, additional, and Valenta, Rudolf, additional

Published
2016
Full Text
View/download PDF

26. HIV microarray for the mapping and characterization of HIV-specific antibody responses

Author

Gallerano, Daniela, primary, Wollmann, Eva, additional, Lupinek, Christian, additional, Schlederer, Thomas, additional, Ebner, Daniel, additional, Harwanegg, Christian, additional, Niespodziana, Katarzyna, additional, Schmetterer, Klaus, additional, Pickl, Winfried, additional, Puchhammer-Stöckl, Elisabeth, additional, Sibanda, Elopy, additional, and Valenta, Rudolf, additional

Published
2015
Full Text
View/download PDF

28. Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides

Author

Hansson, Monika, Mathsson, Linda, Schlederer, Thomas, Israelsson, Lena, Matsson, Per, Nogueira, Leonor, Jakobsson, Per-Johan, Lundberg, Karin, Malmstrom, Vivianne, Serre, Guy, Holmdahl, Rikard, Nystrand, Mats, Klareskog, Lars, Rönnelid, Johan, Hansson, Monika, Mathsson, Linda, Schlederer, Thomas, Israelsson, Lena, Matsson, Per, Nogueira, Leonor, Jakobsson, Per-Johan, Lundberg, Karin, Malmstrom, Vivianne, Serre, Guy, Holmdahl, Rikard, Nystrand, Mats, Klareskog, Lars, and Rönnelid, Johan

Abstract

Introduction: Autoantibodies directed against citrullinated proteins/peptides (ACPAs) are highly specific and predictive for the development of rheumatoid arthritis (RA). Different subgroups of RA patients, which have different prognoses and may require different treatments, are characterized by different autoantibody profiles. The objective of this study was to develop a microarray for the detection of multiple RA-associated autoantibodies, initially focusing on responses against citrullinated epitopes on candidate autoantigens in RA. Methods: The microarray is based on Phadia's ImmunoCAP ISAC system, with which reactivity to more than 100 antigens can be analyzed simultaneously, by using minute serum volumes (<10 mu l). Twelve citrullinated peptides, and the corresponding native arginine-containing control peptides, were immobilized in an arrayed fashion onto a chemically modified glass slide, allowing a three-dimensional layer with high binding capacity. The assay was optimized concerning serum dilution and glass surface, whereas each individual antigen was optimized concerning coupling chemistry, antigen concentration, and selection of spotting buffer. The performance of each peptide in the ImmunoCAP ISAC system was compared with the performance in enzyme-linked immunosorbent assays (ELISAs). Serum from 927 RA patients and 461 healthy controls from a matched case-control study were applied onto reaction sites on glass slides, followed by fluorescent-labeled anti-human immunoglobulin G (IgG) antibody. Fluorescence intensities were detected with a laser scanner, and the results analyzed by using image-analysis software. Results: Strong correlations between the ImmunoCAP ISAC system and ELISA results were found for individual citrullinated peptides (Spearman rho typically between 0.75 and 0.90). Reactivity of RA sera with the peptides was seen mainly in the anticyclic citrullinated peptide 2 (CCP2)-positive subset, but some additional reactivity with single

Published
2012
Full Text
View/download PDF

29. Human IgG detection in serum on polymer based Mach-Zehnder interferometric biosensors.

Author

Melnik, Eva, Bruck, Roman, Müellner, Paul, Schlederer, Thomas, Hainberger, Rainer, and Lämmerhofer, Michael

Abstract

We report a new method for detecting human IgG (hIgG) in serum on integrated-optical Mach-Zehnder interferometer biosensors realized in a high index contrast polymer material system. In the linear range of the sensor (5-200 nM) we observed excellent signal recoveries (95-110%) in buffer and serum samples, which indicate the absence of matrix effects. Signal enhancement was reached by using secondary anti-human IgG antibodies, which bind to immobilized target IgGs and allow detecting concentrations down to 100 pM. This polymer based optical sensor is fully compatible with cost-efficient mass production technologies, which makes it an attractive alternative to inorganic optical sensors. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

30. Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides

Author

Hansson, Monika, primary, Mathsson, Linda, additional, Schlederer, Thomas, additional, Israelsson, Lena, additional, Matsson, Per, additional, Nogueira, Leonor, additional, Jakobsson, Per-Johan, additional, Lundberg, Karin, additional, Malmström, Vivianne, additional, Serre, Guy, additional, Holmdahl, Rikard, additional, Nystrand, Mats, additional, Klareskog, Lars, additional, and Rönnelid, Johan, additional

Published
2012
Full Text
View/download PDF

31. Beiträge zur Chemie der Pyrrolpigmente, 31. Mitt.: Die Spin-Gitter-Relaxation in den1H-NMR-Spektren von Bilatrienen-abc

Author

Falk, Heinz, Haslinger, Ernst, and Schlederer, Thomas

Abstract

The1H-NMR spin lattice relaxation times of aetiobiliverdin-IV-? and biliverdindimethylester were determined using the inversion recovery technique. The relaxation times of protons attached to the terminal rings A and D are longer than those situated at the rings B and C which points to a higher mobility of rings A and D. Moreover these measurements allowed an independent assignment of the1H-NMR-signals of the methyl groups of biliverdindimethylester.

Published
1979
Full Text
View/download PDF

33. Association between asthma and IgG levels specific for rhinovirus and respiratory syncytial virus antigens in children and adults.

Author

Mauclin M, Guillien A, Niespodziana K, Boudier A, Schlederer T, Bajic M, Errhalt P, Borochova K, Pin I, Gormand F, Vernet R, Bousquet J, Bouzigon E, Valenta R, and Siroux V

Abstract

Background: Viral infections in childhood, especially to rhinovirus (RV) and respiratory syncytial virus (RSV), are associated with asthma inception and exacerbation. However, little is known about the role of RV- and RSV-specific antibodies in childhood versus adult asthma., Objective: We sought to investigate associations between RV- and RSV-specific IgG levels and asthma phenotypes in children and adults., Methods: The analysis included 1771 samples from participants of the Epidemiological Study on the Genetics and Environment of Asthma (530 children; age [mean ± SD], 11.1 ± 2.8, and 1241 adults; age [mean ± SD], 43.4 ± 16.7, among whom 274 and 498 had ever asthma, respectively). RSV- and RV-specific IgG levels were determined using microarrayed virus-derived antigens and peptides. Cross-sectional associations between standardized RSV- and RV-specific IgG levels and asthma phenotypes were estimated by multiple regression models., Results: In children, ever asthma was associated with higher IgG levels specific to RV, especially to RV-A and RV-C, and to RSV (adjusted odds ratios [95% CI] for a 1 - SD increase in IgG levels were 1.52 [1.16-1.99], 1.42 [1.10-1.83], and 1.24 [0.99-1.54], respectively). These associations were stronger for moderate to severe asthma than for mild asthma. Conversely in adults, ever asthma was associated with lower RV-A, RV-B, and RV-C IgG levels (adjusted odds ratios [95% CI] were 0.86 [0.74-0.99], 0.83 [0.73-0.95], and 0.85 [0.73-0.99], respectively)., Conclusions: Our results suggest that the association between respiratory virus-specific antibody levels and asthma varies during life, with asthma associated with higher levels of IgG to RSV, RV-A, and RV-C in children and lower levels of IgG responses to RV-A/B/C in adults., Competing Interests: This study was supported in part by NIRVANA (grant no. ANR-19-CE36-0005) and by the Danube Allergy Research Cluster Program (DARC-ARC 2.0) of the country of Lower Austria. Disclosure of potential conflict of interest: R. Valenta has received research grants from Worg Pharmaceuticals, HVD Biotech, and Viravaxx; and serves as a consultant for Viravaxx and Worg. The rest of the authors declare that they have no relevant conflicts of interest., (© 2024 The Authors.)

Published
2024
Full Text
View/download PDF

34. Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes.

Author

Gattinger P, Niespodziana K, Stiasny K, Sahanic S, Tulaeva I, Borochova K, Dorofeeva Y, Schlederer T, Sonnweber T, Hofer G, Kiss R, Kratzer B, Trapin D, Tauber PA, Rottal A, Körmöczi U, Feichter M, Weber M, Focke-Tejkl M, Löffler-Ragg J, Mühl B, Kropfmüller A, Keller W, Stolz F, Henning R, Tancevski I, Puchhammer-Stöckl E, Pickl WF, and Valenta R

Subjects
Antibodies, Viral, Epitopes, Humans, Spike Glycoprotein, Coronavirus genetics, COVID-19, SARS-CoV-2
Abstract

Background: The determinants of successful humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of critical importance for the design of effective vaccines and the evaluation of the degree of protective immunity conferred by exposure to the virus. As novel variants emerge, understanding their likelihood of suppression by population antibody repertoires has become increasingly important., Methods: In this study, we analyzed the SARS-CoV-2 polyclonal antibody response in a large population of clinically well-characterized patients after mild and severe COVID-19 using a panel of microarrayed structurally folded and unfolded SARS-CoV-2 proteins, as well as sequential peptides, spanning the surface spike protein (S) and the receptor-binding domain (RBD) of the virus., Results: S- and RBD-specific antibody responses were dominated by immunoglobulin G (IgG), mainly IgG 1 , and directed against structurally folded S and RBD and three distinct peptide epitopes in S2. The virus neutralization activity of patients´ sera was highly correlated with IgG antibodies specific for conformational but not sequential RBD epitopes and their ability to prevent RBD binding to its human receptor angiotensin-converting enzyme 2 (ACE2). Twenty percent of patients selectively lacked RBD-specific IgG. Only immunization with folded, but not with unfolded RBD, induced antibodies against conformational epitopes with high virus-neutralizing activity. Conformational RBD epitopes required for protection do not seem to be altered in the currently emerging virus variants., Conclusion: These results are fundamental for estimating the protective activity of antibody responses after natural infection or vaccination and for the design of vaccines, which can induce high levels of SARS-CoV-2-neutralizing antibodies conferring sterilizing immunity., (© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results