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27 results on '"Schirone, Antonio"'

1. Encapsulated in sediments: eDNA deciphers the ecosystem history of one of the most polluted European marine sites

Author

Barrenechea Angeles, Ines, Romero-Martínez, Maria Lorena, Cavaliere, Marco, Varrella, Stefano, Francescangeli, Fabio, Piredda, Roberta, Mazzocchi, Maria Grazia, Montresor, Marina, Schirone, Antonio, Delbono, Ivana, Margiotta, Francesca, Corinaldesi, Cinzia, Chiavarini, Salvatore, Montereali, Maria Rita, Rimauro, Juri, Parrella, Luisa, Musco, Luigi, Dell'Anno, Antonio, Tangherlini, Michael, Pawlowski, Jan, and Frontalini, Fabrizio

Published
2023
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2. Interferences between natural and anthropic hazards in marine-coastal environments: Assessing transport from land to the offshore systems in the Crotone basin (Ionian Sea)

Author

Oliveri, Elvira, Ausili, Antonella, Barsanti, Mattia, Conte, Fabio, Delbono, Ivana, Del Core, Marianna, Giaramita, Luigi, Passaro, Salvatore, Placenti, Francesco, Quinci, Enza Maria, Romano, Elena, Sabatino, Nadia, Schirone, Antonio, Tranchida, Giorgio, and Sprovieri, Mario

Published
2022
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3. Heavy metal background levels and pollution temporal trend assessment within the marine sediments facing a brownfield area (Gulf of Pozzuoli, Southern Italy)

Author

Armiento, Giovanna, Barsanti, Mattia, Caprioli, Raffaela, Chiavarini, Salvatore, Conte, Fabio, Crovato, Cinzia, De Cassan, Maurizio, Delbono, Ivana, Montereali, Maria R., Nardi, Elisa, Parrella, Luisa, Pezza, Massimo, Proposito, Marco, Rimauro, Juri, Schirone, Antonio, and Spaziani, Fabio

Published
2022
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12. Benthic Foraminifera as Proxies of Paleoenvironmental Changes in the Sant'Elia-Foxi Canyon (Gulf of Cagliari, Italy, Western Tyrrhenian Sea).

Author

Cristallo, Carla, Buosi, Carla, Francescangeli, Fabio, Bouchet, Vincent M. P., Schirone, Antonio, Tamburrino, Stella, and Frontalini, Fabrizio

Subjects
FORAMINIFERA, CANYONS, ENVIRONMENTAL quality, URBAN growth, RECLAMATION of land, ORGANIC compounds
Abstract

Marine coastal areas are highly dynamic and fragile environments characterised by a complex interplay of biological, physical, and chemical factors. These areas are also affected by anthropogenic activities with the discharge of organic and inorganic contaminants that alters the quality of the environment. In this work, the effects of anthropogenic activities (i.e., urban and industrial development) on benthic foraminifera have been investigated along the A2TM core collected from the Sant'Elia-Foxi Canyon (Gulf of Cagliari, Sardinia—western Tyrrhenian Sea). The Gulf of Cagliari has experienced intense urbanisation since the beginning of the twentieth century with the establishment of petrochemical complexes and harbour activities. The A2TM core, dating from 1907 to 2013, was analysed with an integrated approach that includes grain size, organic matter, and benthic foraminifera characterisation compared with geochemical characterisation. The variations in the composition of the benthic foraminiferal assemblages and the Margalef diversity index are related to the altered environmental conditions that reflect the historical development of the area and to the land-based activities surrounding the Gulf of Cagliari. The statistical analysis identifies two main intervals (i.e., the years 1907–1986 and 1986–2013) that are typified by different benthic foraminiferal assemblages and diversity values. Accordingly, the increases in organic matter content and both organic and inorganic contaminants are well mirrored by a major drop in foraminiferal diversity after 1973 and a major foraminiferal turnover after 1989. The composition of the benthic foraminiferal assemblages in the uppermost part of the core (i.e., 1989–2013) might suggest a lowering of the oxygen availability at the seafloor. These changes might be related to the increase in organic matter and the silty fraction in the same interval likely triggered by damming on land and wetland reclamation. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Correction: Everolimus (Eve) and exemestane (EXE) in patients with advanced breast cancer aged ≥ 65 years: New lessons for clinical practice from the EVA study (Oncotarget (2018) 9:77 (34639-34640) DOI: 10.18632/oncotarget.25874)

Author

Cazzaniga, Marina, Verusio, Claudio, Ciccarese, Mariangela, Fumagalli, Alberto, Sartori, Donata, Ancona, Chiara, Airoldi, Mario, Moretti, Gabriella, Ficorella, Corrado, Arcangeli, Valentina, Diodati, Lucrezia, Zambelli, Alberto, Febbraro, Antonio, Generali, Daniele, Pistelli, Mirco, Garrone, Ornella, Musolino, Antonino, Vici, Patrizia, Maur, Michela, Mentuccia, Lucia, La Verde, Nicla, Bianchi, Giulia, Artale, Salvatore, Blasi, Livio, Piezzo, Michela, Atzori, Francesco, Turletti, Anna, Benedetto, Chiara, Cursano, Maria Concetta, Fabi, Alessandra, Gebbia, Vittorio, Schirone, Antonio, Palumbo, Raffaella, Ferzi, Antonella, Frassoldati, Antonio, Scavelli, Claudio, and Clivio, Luca

Subjects
Oncology
Published
2018

18. Settling fluxes and sediment accumulation rates by the combined use of sediment traps and sediment cores in Tema Harbour (Ghana)

Author

Universidad de Sevilla. Departamento de Física Aplicada I, Universidad de Sevilla. RNM-138: Física Nuclear Aplicada, University of Ghana, Botwe, Benjamin O., Abril Hernández, José María, Schirone, Antonio, Barsanti, Mattia, Delbono, Ivana, Delfanti, Roberta, Nyarko, Elvis, Lens, Piet N.L., Universidad de Sevilla. Departamento de Física Aplicada I, Universidad de Sevilla. RNM-138: Física Nuclear Aplicada, University of Ghana, Botwe, Benjamin O., Abril Hernández, José María, Schirone, Antonio, Barsanti, Mattia, Delbono, Ivana, Delfanti, Roberta, Nyarko, Elvis, and Lens, Piet N.L.

Abstract

Settling fluxes and sediment accumulation rates in coastal Tema Harbour (Ghana) were investigated by the combined analyses of results in sediment traps and sediment cores. Sediment traps were deployed at 5 stations within the Tema Harbour at two sampling depths and were retrieved every two weeks till the end of 12 weeks to estimate the Settling Fluxes (SFs). Four sediment cores from the harbour were analysed for their radioactivity (7Be, 234Th, 210Pb, 212Pb, 226Ra, 40K and 137Cs) profiles to quantify Sediment Accumulation Rates (SARs). The sediment cores exhibited variable bulk density profiles, indicating highly dynamic and non-steady sedimentation conditions. 7Be-derived gross-estimates of very recent SARs using the constant flux-constant sedimentation (CF-CS) model were in the range of 2.5–9.0 g·cm− 2·y− 1. These values were much lower than the estimated average SFs (15.2–53.8 g·cm− 2·y− 1), indicating sediment resuspension plays an important role. On a decadal time scale, conventional 210Pb sediment dating models did not allow any estimation of SARs in the Tema Harbour. Thus, the 210Pb-based TERESA model was applied to depict a reliable scenario for sedimentation with time-averaged SARs in the range of 1.4–3.0 g·cm− 2·y− 1 and fluxes of matter contributed by the marine inflow and local sources. Sediment accretion rates of 1.7–3 cm·y− 1 were also inferred, which may pose a moderate problem of sustainability for the Tema Harbour. This study reveals how the geochemical behaviour of different radionuclides with Gamma spectrometry in the marine environment can be used to obtain reliable information on the complex dynamics of Suspended Particulate Matter (SPM), even in a very disturbed and anthropic environment as a coastal harbour area where (1) conventional 210Pb-based dating methods fail and (2) the use of sediment traps and 234Th and 7Be profiles in sediment cores show serious constraints.

Published
2017

23. IT15-M Mar Ligure

Author

Povero, Paolo, Bavestrello, Giorgio, Castellano, Michela, Massa, Francesco, Dapueto, Giulia, Vassallo, Paolo, Betti, Federico, Bo, Marzia, Fanciulli, Giorgio, Venturini, Sara, Cappanera, Valentina, Campodonico, Pietro, Cocito, Silvia, Ciuffardi, Tiziana, Abbate, Marinella, Barsanti, Mattia, Bordone, Andrea, Cerrati, Gabriella, Conte, Fabio, Delbono, Ivana, Delfanti, Roberta, Di Nallo, Giuseppina, Lombardi, Chiara, Nannini, Matteo, Pannacciulli, Federica, Peirano, Andrea, Raiteri, Giancarlo, and Schirone, Antonio

Subjects
diving, LTER-Italy, LTER, physico-chemical variables along the water column, benthic and fish communities, geoservices, NO cruise tourism, professional and sport fishing, 14. Life underwater, swimming, planktonic, pleasure boating, WEBGis, impact of anthropogenic activities
Abstract

The Promontory of Portofino is placed in a particularly anthropized coastal context, characterized by multiple activities (nautical tourism, diving, bathing, fishing). Since 2005, the Marine Protected Area has been a SPAMI (Specially Protected Area of Mediterranean Interest), RAC/SPA of UNEP. The Eastern Ligurian Sea site includes the Porto Venere Regional Nature Park and the Cinque Terre National Park alongside areas with an industrial footprint and a strong environmental impact (port of La Spezia, shipbuilding, fishing, aquaculture).

24. IT15-M Mar Ligure

Author

Povero, Paolo, Bavestrello, Giorgio, Castellano, Michela, Massa, Francesco, Dapueto, Giulia, Vassallo, Paolo, Betti, Federico, Bo, Marzia, Fanciulli, Giorgio, Venturini, Sara, Cappanera, Valentina, Campodonico, Pietro, Cocito, Silvia, Ciuffardi, Tiziana, Abbate, Marinella, Barsanti, Mattia, Bordone, Andrea, Cerrati, Gabriella, Conte, Fabio, Delbono, Ivana, Delfanti, Roberta, Di Nallo, Giuseppina, Lombardi, Chiara, Nannini, Matteo, Pannacciulli, Federica, Peirano, Andrea, Raiteri, Giancarlo, and Schirone, Antonio

Subjects
diving, LTER-Italy, LTER, physico-chemical variables along the water column, benthic and fish communities, geoservices, NO cruise tourism, professional and sport fishing, 14. Life underwater, swimming, planktonic, pleasure boating, WEBGis, impact of anthropogenic activities
Abstract

The Promontory of Portofino is placed in a particularly anthropized coastal context, characterized by multiple activities (nautical tourism, diving, bathing, fishing). Since 2005, the Marine Protected Area has been a SPAMI (Specially Protected Area of Mediterranean Interest), RAC/SPA of UNEP. The Eastern Ligurian Sea site includes the Porto Venere Regional Nature Park and the Cinque Terre National Park alongside areas with an industrial footprint and a strong environmental impact (port of La Spezia, shipbuilding, fishing, aquaculture).

26. Everolimus (EVE) and exemestane (EXE) in patients with advanced breast cancer aged ≥ 65 years: New lessons for clinical practice from the EVA study

Author

Cazzaniga, M., Verusio, C., Ciccarese, M., Fumagalli, A., Sartori, D., Ancona, C., Airoldi, M., Moretti, G., Ficorella, C., Arcangeli, V., Diodati, L., Zambelli, A., Febbraro, A., Generali, D., Pistelli, M., Garrone, O., Musolino, A., Vici, P., Maur, M., Mentuccia, L., La Verde, N., Bianchi, G., Artale, S., Blasi, L., Piezzo, M., Atzori, F., Turletti, A., Benedetto, C., Cursano, M. C., Fabi, A., Gebbia, V., Schirone, A., Palumbo, R., Ferzi, A., Frassoldati, A., Scavelli, C., Clivio, L., Torri, V., On behalf of The EVA Study Group, Cazzaniga, Marina, Verusio, Claudio, Ciccarese, Mariangela, Fumagalli, Alberto, Sartori, Donata, D'Ancona, Cristina, Airoldi, Mario, Moretti, Gabriella, Ficorella, Corrado, Arcangeli, Valentina, Diodati, Lucrezia, Zambelli, Alberto, Febbraro, Antonio, Generali, Daniele, Pistelli, Mirco, Garrone, Ornella, Musolino, Antonino, Vici, Patrizia, Maur, Michela, Mentuccia, Lucia, La Verde, Nicla, Bianchi, Giulia, Artale, Salvatore, Blasi, Livio, Piezzo, Matilde, Atzori, Francesco, Turletti, Anna, Benedetto, Chiara, Cursano, Maria Concetta, Fabi, Alessandra, Gebbia, Vittorio, Schirone, Antonio, Palumbo, Raffaella, Ferzi, Antonella, Frassoldati, Antonio, Scavelli, Claudio, Clivio, Luca, Torri, Valter, Cazzaniga, M, Verusio, C, Ciccarese, M, Fumagalli, A, Sartori, D, Ancona, C, Airoldi, M, Moretti, G, Ficorella, C, Arcangeli, V, Diodati, L, Zambelli, A, Febbraro, A, Generali, D, Pistelli, M, Garrone, O, Musolino, A, Vici, P, Maur, M, Mentuccia, L, La Verde, N, Bianchi, G, Artale, S, Blasi, L, Piezzo, M, Atzori, F, Turletti, A, Benedetto, C, Cursano, M, Fabi, A, Gebbia, V, Schirone, A, Palumbo, R, Ferzi, A, Frassoldati, A, Scavelli, C, Clivio, L, Torri, V, On behalf of The EVA Study, G, Cazzaniga M., Verusio C., Ciccarese M., Fumagalli A., Sartori D., Valerio MR., Airoldi M., Moretti G., Ficorella C., Arcangeli V., Diodati L., Zambelli A., Febbraro A., Generali D., Pistelli M., Garrone O., Musolino A., Vici P., Maur M., Mentuccia L., La Verde N., Bianchi G., Artale S., Blasi L., Piezzo M., Atzori F., Turletti A., Benedetto C., Cursano M.C., Fabi A., Gebbia V., Schirone A., Palumbo R., Ferzi A., Frassoldati A., Scavelli C., Clivio L., Torri V., and On behalf of The EVA Study Group

Subjects
medicine.medical_specialty, Socio-culturale, Hormone-receptor positive, Exemestane, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, Elderly, Weight loss, Internal medicine, Advanced breast cancer, Everolimus, Oncology, medicine, 030212 general & internal medicine, Stomatitis, Pneumonitis, business.industry, Cancer, medicine.disease, Rash, Everolimu, chemistry, 030220 oncology & carcinogenesis, MED/06 - ONCOLOGIA MEDICA, medicine.symptom, business, Research Paper, medicine.drug
Abstract

BACKGROUND: The present analysis focuses on real-world data of Everolimus- Exemestane in advanced HR+ve, HER2-ve elderly breast cancer patients (aged 65 years) included in the EVA study, with unique findings in those aged 70 years. METHODS: Data are collected from clinical records and analysed according to age cut-off (< 65 years; 65 - 69 years and [greater than or equal to] 70 years). Relationship of analyzed variables with response were tested by mean of a Mantel- Haenszel chi square test. Time to event analysis was described by Kaplan Meier approach and association with baseline characteristics was analysed by stratified log-rank test and proportional hazard model. RESULTS: From July 2013 to December 2015, the EVA study enrolled overall 404 pts. 154 patients out of 404 (38,1%) were aged [greater than or equal to] 65 years, of whom 87 were [greater than or equal to] 70 years. Median duration of EVE treatment was 28.5 weeks (95% CI 19.0 - 33.8) in patients aged 65-69 years and 24,4 weeks (95% CI 19,2 - 33,2) in those aged [greater than or equal to] 70 years. Fewer patients aged 65 years received the highest EVE Dose-Intensity (> 7.5 mg/day) in comparison to younger patients (49,6% vs. 66,8%). Grade 3-4 toxicities occurred to 55 patients (35,7%), mainly stomatitis (10,9%), rash (5,8%) and non-infectious pneumonitis (NIP) (3,6%). Some toxicities, such as weight loss and anaemia were peculiarly observed in patients aged [greater than or equal to] 70 years. Five treatment-related deaths were collected (3,2%). CONCLUSIONS: EVE-EXE combination remains one of the potential treatments in HR+ patients also for elderly ones.

Published
2018

27. Everolimus (EVE) and exemestane (EXE) in patients with advanced breast cancer aged ≥ 65 years: new lessons for clinical practice from the EVA study.

Author

Cazzaniga M, Verusio C, Ciccarese M, Fumagalli A, Sartori D, Valerio MR, Ancona C, Airoldi M, Moretti G, Ficorella C, Arcangeli V, Diodati L, Zambelli A, Febbraro A, Generali D, Pistelli M, Garrone O, Musolino A, Vici P, Maur M, Mentuccia L, La Verde N, Bianchi G, Artale S, Blasi L, Piezzo M, Atzori F, Turletti A, Benedetto C, Cursano MC, Fabi A, Gebbia V, Schirone A, Palumbo R, Ferzi A, Frassoldati A, Scavelli C, Clivio L, and Torri On Behalf Of The Eva Study Group V

Abstract

Background: The present analysis focuses on real-world data of Everolimus-Exemestane in advanced HR+ve, HER2-ve elderly breast cancer patients (aged 65 years) included in the EVA study, with unique findings in those aged 70 years., Methods: Data are collected from clinical records and analysed according to age cut-off (< 65 years; 65 - 69 years and {greater than or equal to} 70 years). Relationship of analyzed variables with response were tested by mean of a Mantel-Haenszel chi square test. Time to event analysis was described by Kaplan Meier approach and association with baseline characteristics was analysed by stratified log-rank test and proportional hazard model., Results: From July 2013 to December 2015, the EVA study enrolled overall 404 pts. 154 patients out of 404 (38,1%) were aged {greater than or equal to} 65 years, of whom 87 were {greater than or equal to} 70 years. Median duration of EVE treatment was 28.5 weeks (95% CI 19.0 - 33.8) in patients aged 65-69 years and 24,4 weeks (95% CI 19,2 - 33,2) in those aged {greater than or equal to} 70 years. Fewer patients aged 65 years received the highest EVE Dose-Intensity (>7.5 mg/day) in comparison to younger patients (49,6% vs. 66,8%). Grade 3-4 toxicities occurred to 55 patients (35,7%), mainly stomatitis (10,9%), rash (5,8%) and non-infectious pneumonitis (NIP) (3,6%). Some toxicities, such as weight loss and anaemia were peculiarly observed in patients aged {greater than or equal to} 70 years. Five treatment-related deaths were collected (3,2%)., Conclusions: EVE-EXE combination remains one of the potential treatments in HR+ patients also for elderly ones., Competing Interests: CONFLICTS OF INTEREST The Authors declare that they have no conflicts of interest.

Published
2018
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