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130 results on '"Schippert C"'

9. Reproductive capacity and recurrence of disease after surgery for moderate and severe endometriosis

Author

Guillermo-José Garcia-Rocha, YJ Witte, Hillemanns P, Jentschke M, Schippert C, Bartels J, and S Kundu

Subjects
medicine.medical_specialty, Text mining, business.industry, Internal medicine, Severe endometriosis, Medicine, Reproductive capacity, Disease, business
Abstract

Background Endometriosis can be associated with considerable pain and sterility. After surgical excision of moderate or severe endometriosis the recurrence rates amount to 50%. The objective of this retrospective study was to evaluate the recurrence and pregnancy rates following surgical resection of endometriosis stage III/IV. Methods 456 patients who underwent stage III/IV endometriosis surgery between 2004 and 2014 were sent a questionnaire relating to postoperative medical treatment, pregnancies, relief of symptoms and recurrence. Data and responses of 206 patients (45.2%) were analyzed. The statistical analysis was performed with the statistical software ´R`. Statistical significance was given if the p-value was less than 0.05. The study was approved by the local Ethics Committee of Hannover Medical School. Results 66.5% (N=137) of patients were established with stage III, 33.5% (N=69) with stage IV. Average age was 37 years (17-59). 63.1% (N=130) of surgeries were performed by laparoscopy with an average duration of 81 minutes, 21.8% (N=45; 189 minutes) by laparotomy and 15% (N=31; 202 minutes) by conversion. Complete resection of endometriosis was achieved in 90.8% (N=187). After surgery, 48.5% (N=100) of the women did not receive hormonal treatment, main reason was the desire for children in 53%. Complete or partial relief in complaints was achieved in 93.2% (N=192). Rate of recurrence was 21.8% (N=45). The association between incomplete resection and recurrence was on the threshold of significance (p=0.1). After surgery, 65.8% (79/120) of patients who wished to have children got pregnant. There is a statistically significant association between postoperative pregnancy rate and age

Published
2020
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12. Cancers in Patients with Endometriosis

Author

Blum, S, additional, Häberle, L, additional, Tchartchian, G, additional, Schippert, C, additional, Fehm, T, additional, Hartung, CP, additional, Widschwendter, P, additional, Reicke, S, additional, Füger, T, additional, Germeyer, A, additional, Oppelt, P, additional, Lange, J, additional, Fleisch, M, additional, Renner, SP, additional, Hein, A, additional, Fasching, PA, additional, Beckmann, MW, additional, and Burghaus, S, additional

Published
2018
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50. Clinical characterisation of women with persistent genital arousal disorder: the iPGAD-study.

Author

Kümpers FMLM, Sinke C, Schippert C, Kollewe K, Körner S, Raab P, Meyer B, Maschke S, Karst M, Sperling C, Dalkeranidis E, and Krüger THC

Subjects
Female, Humans, Sexual Behavior psychology, Genitalia, Arousal physiology, Coitus, Pelvic Pain, Sexual Dysfunction, Physiological etiology
Abstract

Persistent Genital Arousal Disorder (PGAD) is a rare condition-mostly in women-where patients perceive prolonged genital arousal without any sexual desire or stimulation. Etiopathological considerations reach from peripheral to central issues over local disturbance of the pudendal nerve to neuropathy, psychosocial, and pharmacological theories. Since well controlled clinical studies about PGAD in conjunction with a mental and somatic health status are missing, this study is a detailed clinical investigation of PGAD patients compared to healthy controls. 26 women who fulfilled diagnostic criteria for PGAD were compared to 26 age matched healthy controls. Investigations included comparison of vegetative, gynaecological and sexual history, psychiatric features as well as a (neuro-)radiological, neurophysiological and gynaecological examination. Moreover, a detailed clinical characterisation of PGAD symptoms was performed. PGAD symptoms were mostly characterised as tingling or prickling and were permanently present. In over 80%, PGAD symptoms were located in the clitoris. Almost 70% reported radiations to other regions of the body. Most frequent trigger factors were tight clothes, mental stress, driving a car/bus/bicycle and sexual intercourse. Relieving factors were mainly distraction, relaxation, physical exercise, masturbation and swimming. In group comparisons, PGAD presented with significant higher rates of sexual dysfunctions, spontaneous orgasms, swelling of the genitals, extraordinary lubrication as well as higher rates in depression, agoraphobia, generalized anxiety disorder and lifetime panic disorder. Significantly more PGAD patients were diagnosed with restless legs symptoms. In contrast childhood traumatization, somatization disorder, suicidality, gynaecological as well as neurophysiological examination of the pudendal nerve were not different between the groups. MRI of the brain, pelvis and spinal cord was unsuspicious and incidental findings - including Tarlov cysts or pelvic venous congestion - were equally distributed among the groups. In summary, our study provides a careful characterization of women with PGAD highlighting a serious mental burden, most probably as a consequence of PGAD. With the current set of clinical investigations there was no evidence of a clear causal relationship to a specific clinical finding as it has been previously discussed. Future studies and additional techniques will have to further explore where and how in the peripheral or central nervous systems PGAD develops., (© 2023. The Author(s).)

Published
2023
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