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673 results on '"Schipper, H."'

3. Targeted inhibition of glycogen synthase kinase-3 using 9-ING-41 (elraglusib) enhances CD8 T-cell-reactivity against neuroblastoma cells

Author

CTI Boes, Infection & Immunity, Sociale pediatrie onderzoek 2, Child Health, Circulatory Health, Zorg en O&O, Markovska, A, Somers, K, Guillaume, J, Melief, J, Mazar, A P, Schmitt, D M, Schipper, H S, Boes, M, CTI Boes, Infection & Immunity, Sociale pediatrie onderzoek 2, Child Health, Circulatory Health, Zorg en O&O, Markovska, A, Somers, K, Guillaume, J, Melief, J, Mazar, A P, Schmitt, D M, Schipper, H S, and Boes, M

Published
2024

5. Recombinant Gonadotropins to Induce Oocyte Development In Vitro and In Vivo in the European Eel Anguilla anguilla

Author

Jéhannet, P.J.M., Palstra, A.P., Giménez Nebot, I., Schipper, H., Swinkels, William, Heinsbroek, L.T.N., Komen, J., Jéhannet, P.J.M., Palstra, A.P., Giménez Nebot, I., Schipper, H., Swinkels, William, Heinsbroek, L.T.N., and Komen, J.

Abstract

Commonly, female European eels are injected weekly with pituitary extract (PE) from carp (CPE) or salmon (SPE) to induce sexual maturation. However, a PE is a mixture of go-nadotropins and other hormones that are not specific for eel and rapidly cleared from circulation.The aim of this study was therefore to test the effects of highly stable eel-specific recombinant gonadotropins (rGTHs) on oocyte development in vitro and in vivo in European eels. For thein vitro trial, the dose–effect responses of maturing eel oocytes on CPE and recombinant luteinizing hormone (rLH) were studied before and after 12 and 18 h of incubation. For the in vivo experiment,sexual maturation was stimulated by treatment with (i) CPE, (ii) recombinant follicle-stimulating hormone (rFSH) followed by CPE and (iii) rFSH followed by rLH. For the in vitro experiment, theexpression of the nuclear progestin receptor 2 (pgr2) was induced by rLH, implying that rLH was preparing the oocyte for ovulation. For the in vivo experiment, the females treated with rGTHshad high gonadosomatic index (GSI) values (rFSH-CPE: 75, 77; rFSH-rLH: 80) in comparison with the females injected with CPE (50–60), suggesting that rFSH strongly induced vitellogenic growth. Larvae were produced for all treatment groups and for the first time by rGTH treatment alone but dose and timing still need optimization.

Published
2023

9. The induction of oocyte maturation and ovulation in European eel (Anguilla anguilla): in vitro and in vivo comparison of progesterone with 17α,20β-dihydroxy-4-pregnen-3-one

Author

Jéhannet, P.J.M., Palstra, A.P., Meijerhof, M., Schipper, H., Giménez Nebot, I., Swinkels, W., Heinsbroek, L.T.N., Dirks, R.P., and Komen, J.

Subjects
Experimentele Zoologie, WIAS, Life Science, Fokkerij en Genomica, Animal Breeding and Genomics, Fokkerij & Genomica, Experimental Zoology, Animal Breeding & Genomics
Published
2022

10. Abstracts

Author

Feinstein, D. L., Galea, E., Rolland, B., Fages, C., Charmeteau, B., Tardy, M., Philbert, M. A., Reuhl, K. R., Primiano, T., Novak, R. F., Lowndes, H. E., Lake, Norma, Neuhaus, J., Fedoroff, S., Abd-El-Basset, E. M., Blevins, G., Devon, R., Doucette, R., Bruner, G., Murphy, S., Rathbone, M. P., Simmons, M. L., Reis, D. J., Latzkovits, L., Cserr, H. F., Patlak, C. S., Pettigrew, K. D., Rimanoczy, A., Juurlink, B. H. J., Robitaille, R., Jahromi, B. S., Charlton, M. P., Ang, L. C., Bhaumick, B., Westmeyer, A., Junghans, U., Müller, H. W., Schmalenbach, C., Sass, J. B., Giffard, R. G., Bruno, V. M., Dugan, L. L., Amagasu, S. A., Makarenko, I. G., Aksenova, M. V., Stagaard-Janas, M., Møllgård, K., Græm, N., Møller, A., Mydlarski, M. B., Schipper, H. M., Ye, X., Carp, R. I., Kascsak, R., Kozielski, R., Kozlowski, P., Yong, W. W., Wright, E., Tejada-Berges, T., Anthes, D. L., Theriault, E., Tator, C. H., Chan-Ling, T., Trout, S., Holländer, H., Stone, J., Wu, W., Toma, J. G., Miller, F. D., Pareek, S., Barker, P., Mathew, T. C., Murphy, R. A., Acheson, A., Moffett, C. W., Paden, C. M., Levine, R. L., Skibo, G. G., Berezovskaya, O. L., Rusakow, D. A., Fedoroff, Sergey, editor, Burkholder, Gary D., editor, Juurlink, Bernhard H. J., editor, and Doucette, Ronald, editor

Published
1993
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18. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio)

Author

van der Meulen, T., Schipper, H., van den Boogaart, J.G.M., Huising, M.O., Kranenbarg, S., and van Leeuwen, J.L.

Subjects
Heart muscle -- Physiological aspects, Endurance sports -- Health aspects, Endurance sports -- Physiological aspects, Biological sciences
Abstract

Mechanical load is an important factor in the differentiation of cells and tissues. To investigate the effects of increased mechanical load on development of muscle and bone, zebrafish were subjected to endurance swim training for 6 h/day for 10 wk starting at 14 days after fertilization. During the first 3 wk of training, trained fish showed transiently increased growth compared with untrained (control) fish. Increased expression of proliferating cell nuclear antigen suggests that this growth is realized in part through increased cell proliferation. Red and white axial muscle fiber diameter was not affected. Total cross-sectional area of red fibers, however, was increased. An improvement in aerobic muscle performance was supported by an increase in myoglohin expression. At the end of 10 wk of training, heart and axial muscle showed increased expression of the muscle growth factor myogenin and proliferating cell nuclear antigen, but there were major differences between cardiac and axial muscle. In axial muscle, expression of the 'slow' types of myosin and troponin C was increased, together with expression of erythropoietin and myoglobin, which enhance oxygen transport, indicating a shift toward a slow aerobic phenotype. In contrast, the heart muscle shifts to a faster phenotype but does not become more aerobic. This suggests that endurance training differentially affects heart and axial muscle. endurance exercise; mechanical load; aerobic muscle development

Published
2006

22. Nationwide comprehensive gastro-intestinal cancer cohorts

Author

Braak, R.R.J.C. van den, Rijssen, L.B. van, Kleef, J.J. van, Vink, G.R., Berbee, M., Henegouwen, M.I.V., Bloemendal, H.J., Bruno, M.J., Burgmans, M.C., Busch, O.R.C., Coene, P.P.L.O., Coupe, V.M.H., Dekker, J.W.T., Eijck, C.H.J. van, Elferink, M.A.G., Erdkamp, F.L.G., Grevenstein, W.M.U. van, Groot, J.W.B. de, Grieken, N.C.T. van, Hingh, I.H.J.T. de, Hulshof, M.C.C.M., Ijzermans, J.N.M., Kwakkenbos, L., Lemmens, V.E.P.P., M. los, Meijer, G.A., Molenaar, I.Q., Nieuwenhuijzen, G.A.P., Noo, M.E. de, Poll-Franse, L.V. van de, Punt, C.J.A., Rietbroek, R.C., Roeloffzen, W.W.H., Rozema, T., Ruurda, J.P., Sandick, J.W. van, Schiphorst, A.H.W., Schipper, H., Siersema, P.D., Slingerland, M., Sommeijer, D.W., Spaander, M.C.W., Sprangers, M.A.G., Stockmann, H.B.A.C., Strijker, M., Tienhoven, G. van, Timmermans, L.M., Tjin-a-Ton, M.L.R., Velden, A.M.T. van der, Verhaar, M.J., Verkooijen, H.M., Vles, W.J., Vos-Geelen, J.M.P.G.M. de, Wilmink, J.W., Zimmerman, D.D.E., Oijen, M.G.H. van, Koopman, M., Besselink, M.G.H., Laarhoven, H.W.M. van, Dutch Pancreatic Canc Grp, Dutch Upper GI Canc Grp, PLCRC Working Grp, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiotherapie, Promovendi ODB, MUMC+: MA Radiotherapie OC (9), Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), CCA - Cancer Treatment and quality of life, APH - Methodology, Epidemiology and Data Science, AGEM - Re-generation and cancer of the digestive system, Pathology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, Surgery, Graduate School, Radiotherapy, Oncology, APH - Aging & Later Life, APH - Mental Health, Medical Psychology, APH - Quality of Care, Gastroenterology & Hepatology, Public Health, Erasmus MC other, and Medical and Clinical Psychology

Subjects
0301 basic medicine, medicine.medical_specialty, INFRASTRUCTURE, law.invention, COLORECTAL-CANCER, Cohort Studies, Experimental Psychopathology and Treatment, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Cancer development and immune defence Radboud Institute for Health Sciences [Radboudumc 2], 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, Randomized controlled trial, SDG 3 - Good Health and Well-being, DESIGN, law, Informed consent, MOLECULAR SUBTYPES, medicine, Humans, QUALITY, Radiology, Nuclear Medicine and imaging, Registries, Biological Specimen Banks, Gastrointestinal Neoplasms, Randomized Controlled Trials as Topic, ESOPHAGEAL, INFORMED-CONSENT, business.industry, Clinical study design, Cancer, Hematology, General Medicine, medicine.disease, Surgery, Cancer registry, Clinical trial, Observational Studies as Topic, 030104 developmental biology, Oncology, Research Design, 030220 oncology & carcinogenesis, Cohort, Emergency medicine, business, CLINICAL-TRIALS, Cohort study
Abstract

Contains fulltext : 190038.pdf (Publisher’s version ) (Open Access) Background: The increasing sub-classification of cancer patients due to more detailed molecular classification of tumors, and limitations of current trial designs, require innovative research designs. We present the design, governance and current standing of three comprehensive nationwide cohorts including pancreatic, esophageal/gastric, and colorectal cancer patients (NCT02070146). Multidisciplinary collection of clinical data, tumor tissue, blood samples, and patient-reported outcome (PRO) measures with a nationwide coverage, provides the infrastructure for future and novel trial designs and facilitates research to improve outcomes of gastrointestinal cancer patients.Material and methods: All patients aged ≥18 years with pancreatic, esophageal/gastric or colorectal cancer are eligible. Patients provide informed consent for: (1) reuse of clinical data; (2) biobanking of primary tumor tissue; (3) collection of blood samples; (4) to be informed about relevant newly identified genomic aberrations; (5) collection of longitudinal PROs; and (6) to receive information on new interventional studies and possible participation in cohort multiple randomized controlled trials (cmRCT) in the future.Results: In 2015, clinical data of 21,758 newly diagnosed patients were collected in the Netherlands Cancer Registry. Additional clinical data on the surgical procedures were registered in surgical audits for 13,845 patients. Within the first two years, tumor tissue and blood samples were obtained from 1507 patients; during this period, 1180 patients were included in the PRO registry. Response rate for PROs was 90%. The consent rate to receive information on new interventional studies and possible participation in cmRCTs in the future was >85%. The number of hospitals participating in the cohorts is steadily increasing.Conclusion: A comprehensive nationwide multidisciplinary gastrointestinal cancer cohort is feasible and surpasses the limitations of classical study designs. With this initiative, novel and innovative studies can be performed in an efficient, safe, and comprehensive setting. 8 p.

Published
2018
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40. Schrijven in boeken

Author

Kuitert, L., Swaanswijk, M., den Boon, T., Schipper, H., and AHM (FGw)

Abstract

General introduction on the phenomenon of readers writing in their books

Published
2019

42. Predicting Outcome After Hand Orthosis and Hand Therapy for Thumb Carpometacarpal Osteoarthritis: A Prospective Study

Author

Tsehaie, Jonathan, Spekreijse, Kim, Wouters, Robbert, Feitz, R, Hovius, Steven, Slijper, Harm, Selles, Ruud, Blomme, A, Sluijter, B, Schouten, C, van der Avoort, DJ, Walbeehm, E, van Couwelaar, G, Vermeulen, G, Schipper, H, Temming, H, van Uchelen, J, Boer, LM, Haas, N, Zophel, O, Souer, S, Moojen, T, Smit, Xander, van Huis, R, Pennehouat, PY, Schoneveld, K, van Kooij, Y, Zagt, P, van Ewijk, F, Moussault, F, van Houwelingen, R, Veltkamp, J, Velde, A, Fink, A, Porsius, J, Zhou, C, Poelstra, Ralph, Janssen, M, van der Oest, Mark, Evers, Stefanie, Dekker, J, Jong, M, van Gestel, J, ter Stege, M, Dekker, Marieke, Faber, R (Renaldo), Santegoets, FJP, Sieber-Rasch, M, Gerritsen, T, Plastic and Reconstructive Surgery and Hand Surgery, Rehabilitation Medicine, Erasmus MC other, and Public Health

Subjects
Male, Orthotic Devices, 030506 rehabilitation, medicine.medical_specialty, Visual analogue scale, Hand therapy, Physical Therapy, Sports Therapy and Rehabilitation, Osteoarthritis, Thumb, Conservative Treatment, Outcome (game theory), 03 medical and health sciences, 0302 clinical medicine, Musculoskeletal Pain, medicine, Humans, Prospective Studies, Prospective cohort study, book, Aged, Pain Measurement, business.industry, Rehabilitation, Carpometacarpal Joints, Middle Aged, medicine.disease, Exercise Therapy, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Treatment Outcome, medicine.anatomical_structure, Splints, Patient Satisfaction, Physical therapy, book.journal, Female, Observational study, 0305 other medical science, business, 030217 neurology & neurosurgery, Cohort study
Abstract

Item does not contain fulltext OBJECTIVES: (1) To identify predictive factors for outcome after splinting and hand therapy for carpometacarpal (CMC) osteoarthritis (OA) and to identify predictive factors for conversion to surgical treatment; and (2) to determine how many patients who have not improved in outcome within 6 weeks after start of treatment will eventually improve after 3 months. DESIGN: Observational prospective multicenter cohort study. SETTING: Xpert Clinic in the Netherlands. This clinic comprises 15 locations in the Netherlands, with 16 European Board certified (FESSH) hand surgeons and over 50 hand therapists. PARTICIPANTS: Between 2011 and 2014, patients with CMC OA (N=809) received splinting and weekly hand therapy for 3 months. INTERVENTION: Not applicable. MAIN OUTCOME MEASURES: Satisfaction and pain were measured with a visual analog scale and function with the Michigan Hand Questionnaire at baseline, 6 weeks, and 3 months posttreatment. Using regression analysis, patient demographics and pretreatment baseline scores were considered as predictors for the outcome of conservative treatment after 3 months and for conversion to surgery. RESULTS: Multivariable regression model explained 34%-42% of the variance in outcome (P

Published
2019

43. Lucebert: De zin van het lezen

Author

Kuitert, L., Swaanswijk, M., den Boon, T., Schipper, H., and AHM (FGw)

Abstract

Book about traces of reading, 'marginalia' in Luceberts books.

Published
2019

50. Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation

Author

Rakhshandehroo, M., Eijkeren, R. van, Gabriel, T., Haar, C. De, Gijzel, S.M.W., Hamers, N., Ferraz, M., Aerts, J., Schipper, H., Eijk, M. van, Boes, M., Kalkhoven, E., Rakhshandehroo, M., Eijkeren, R. van, Gabriel, T., Haar, C. De, Gijzel, S.M.W., Hamers, N., Ferraz, M., Aerts, J., Schipper, H., Eijk, M. van, Boes, M., and Kalkhoven, E.

Abstract

Contains fulltext : 207077.pdf (publisher's version ) (Open Access)

Published
2019

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