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18 results on '"Schinocca L"'

3. Influence of posture on swallowing

Author

Aurea Maria Immacolata LUMBAU, Schinocca L, and Chessa G

Subjects
Male, Lingual Frenum, Eye Movements, Posture, Open Bite, Tongue Habits, Deglutition, Tongue, Humans, Female, Child, Deglutition Disorders, Postural Balance, Vision, Ocular
Abstract

This study investigates the relationship between posture disorders and swallowing, either of infantile type or affected by the presence of a short lingual frenulum.The stabilometry examinations, taking into account the Romberg index and the LFS value, and when needed a frenectomy, showed positive variations in the recovery of a proper posture. The data were analysed by means of the Wilcoxon signed-rank test.This study showed that swallowing is able to modulate postural control and it can be a determining factor in postural syndromes that, if not promptly intercepted, may evolve into full-blown and irreversible musculoskeletal disorders for which treatment often proves ineffective.

Published
2011

12. Management and long-term follow-up of early stage H. pylori-associated gastric MALT-lymphoma in clinical practice: an Italian, multicentre study

Author

Andriani, A, Miedico, A, Tedeschi, Luigi, Patti, C, Di Raimondo, F, Leone, M, Schinocca, L, Romanelli, A, Bonanno, George, Linea, C, Giustini, M, Hassan, Cesare, Cottone, M, Zullo, A., Andriani, A, Miedico, A, Tedeschi, Luigi, Patti, C, Di Raimondo, F, Leone, M, Schinocca, L, Romanelli, A, Bonanno, George, Linea, C, Giustini, M, Hassan, Cesare, Cottone, M, and Zullo, A.

Abstract

Data on management and long-term follow-up of Helicobacter pylori-associated MALT-lymphoma in clinical practice are scanty. We evaluate the long-term efficacy of H. pylori eradication on low-grade MALT-lymphoma, and the efficacy of further therapies in refractory patients.

Published
2009

15. Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms

Author

Rita Barone, Valeria Cigna, Clementina Caracciolo, Giorgia Saccullo, Luciana Schinocca, Domenica Caramazza, Gerlando Quintini, Vincenzo Abbadessa, Alessandra Malato, Salvatore Berretta, Sergio Siragusa, Francesco Di Raimondo, Caramazza, D, Caracciolo, C, Barone, R, Malato, A, Saccullo, G, Cigna, V, Berretta, S, Schinocca, L, Quintini, G, Abbadessa, V, Di Raimondo, F, and Siragusa, S

Subjects
Male, medicine.medical_specialty, Pathology, Leukocytosis, myeloproliferative neoplasm, thrombosis, jak2, Gastroenterology, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Settore MED/15 - Malattie Del Sangue, Leukocyte Count, Polycythemia vera, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Hydroxyurea, Risk factor, Prospective cohort study, Polycythemia Vera, Myeloproliferative neoplasm, Aged, business.industry, Essential thrombocythemia, Hazard ratio, Thrombosis, Hematology, General Medicine, Janus Kinase 2, Middle Aged, medicine.disease, Multivariate Analysis, Female, medicine.symptom, business, Thrombocythemia, Essential
Abstract

The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed the clinical course of 187 patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) followed at two Italian Institutions over a period of 7 years. The association was measured at diagnosis or before thrombotic events: a multivariable analysis was carried out using data at baseline and time-dependent covariates. We found that white blood cells (WBC) count above 9.5 x 10(9)/L at diagnosis (baseline analysis) was associated with thrombosis during the follow-up (Hazard Ratio [HR] of 1.8, p 0.03). At the time-dependent analysis, therapy with hydroxyurea (HU), lowering by 35% the baseline WBC level, reduced such strength of association giving a HR of 1.3 (p value non significant). We found a trend between WBC level and thrombosis in untreated low-risk patients (RR of 1.9, 95% CI 0.9 to 3.1); in high-risk patients treated with HU this correlation was clearly lost (RR 1.1, 95% CI 0.2 to 2.7). Finally, we could not identify the presence of JAK2 (V617F) as a risk factor for thrombosis. Properly designed prospective studies should corroborate such results. The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed the clinical course of 187 patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) followed at two Italian Institutions over a period of 7 years. The association was measured at diagnosis or before thrombotic events: a multivariable analysis was carried out using data at baseline and time-dependent covariates. We found that white blood cells (WBC) count above 9.5 x 10(9)/L at diagnosis (baseline analysis) was associated with thrombosis during the follow-up (Hazard Ratio [HR] of 1.8, p 0.03). At the time-dependent analysis, therapy with hydroxyurea (HU), lowering by 35% the baseline WBC level, reduced such strength of association giving a HR of 1.3 (p value non significant). We found a trend between WBC level and thrombosis in untreated low-risk patients (RR of 1.9, 95% CI 0.9 to 3.1); in high-risk patients treated with HU this correlation was clearly lost (RR 1.1, 95% CI 0.2 to 2.7). Finally, we could not identify the presence of JAK2 (V617F) as a risk factor for thrombosis. Properly designed prospective studies should corroborate such results.

Published
2009

16. Influence of posture on swallowing.

Author

Lumbau A, Schinocca L, and Chessa G

Subjects
Child, Deglutition Disorders physiopathology, Deglutition Disorders therapy, Eye Movements physiology, Female, Humans, Lingual Frenum abnormalities, Lingual Frenum surgery, Male, Open Bite physiopathology, Open Bite therapy, Postural Balance physiology, Tongue abnormalities, Tongue physiopathology, Tongue Habits adverse effects, Tongue Habits therapy, Vision, Ocular physiology, Deglutition physiology, Posture physiology
Abstract

Aim: This study investigates the relationship between posture disorders and swallowing, either of infantile type or affected by the presence of a short lingual frenulum., Materials and Methods: The stabilometry examinations, taking into account the Romberg index and the LFS value, and when needed a frenectomy, showed positive variations in the recovery of a proper posture. The data were analysed by means of the Wilcoxon signed-rank test., Results and Conclusion: This study showed that swallowing is able to modulate postural control and it can be a determining factor in postural syndromes that, if not promptly intercepted, may evolve into full-blown and irreversible musculoskeletal disorders for which treatment often proves ineffective.

Published
2011

17. Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms.

Author

Caramazza D, Caracciolo C, Barone R, Malato A, Saccullo G, Cigna V, Berretta S, Schinocca L, Quintini G, Abbadessa V, Di Raimondo F, and Siragusa S

Subjects
Aged, Female, Humans, Hydroxyurea pharmacology, Hydroxyurea therapeutic use, Janus Kinase 2 genetics, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative complications, Leukocyte Count, Leukocytosis drug therapy, Male, Middle Aged, Multivariate Analysis, Leukocytosis complications, Polycythemia Vera complications, Thrombocythemia, Essential complications, Thrombosis etiology
Abstract

The evidence that leukocytes may contribute to the pathogenesis of thrombosis in Chronic Myeloproliferative Neoplasms is increasing but not definitive. To further enforces whether an increased leukocyte count is associated with thrombosis and whether this effect can be modulated by cytoreductive therapy, we analyzed the clinical course of 187 patients with Polycythemia Vera (PV) and Essential Thrombocythemia (ET) followed at two Italian Institutions over a period of 7 years. The association was measured at diagnosis or before thrombotic events: a multivariable analysis was carried out using data at baseline and time-dependent covariates. We found that white blood cells (WBC) count above 9.5 x 10(9)/L at diagnosis (baseline analysis) was associated with thrombosis during the follow-up (Hazard Ratio [HR] of 1.8, p 0.03). At the time-dependent analysis, therapy with hydroxyurea (HU), lowering by 35% the baseline WBC level, reduced such strength of association giving a HR of 1.3 (p value non significant). We found a trend between WBC level and thrombosis in untreated low-risk patients (RR of 1.9, 95% CI 0.9 to 3.1); in high-risk patients treated with HU this correlation was clearly lost (RR 1.1, 95% CI 0.2 to 2.7). Finally, we could not identify the presence of JAK2 (V617F) as a risk factor for thrombosis. Properly designed prospective studies should corroborate such results.

Published
2009
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18. Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in histone H4.

Author

Zoroddu MA, Schinocca L, Kowalik-Jankowska T, Kozlowski H, Salnikow K, and Costa M

Subjects
Amino Acid Sequence, Binding Sites physiology, Copper adverse effects, Copper pharmacokinetics, Humans, Molecular Sequence Data, Nickel pharmacokinetics, Spectrum Analysis, Structure-Activity Relationship, Cell Transformation, Neoplastic, Histones chemistry, Models, Chemical, Nickel adverse effects
Abstract

Ni(II) compounds are well known as human carcinogens, though the molecular events which are responsible for this are not yet fully understood. It has been proposed that the binding of N(II) ions within the cell nucleus is a crucial element in the mechanism of carcinogenesis. The most abundant proteins in the cell nucleus are histones, and this makes them the prime candidates for this role. This article is a review of our recent studies of histone H4 models of Ni(II) binding. We analyzed the sequence of the N-terminal tail of the histone H4, Ac-SGRGKGGKGLGKGGAKRH(18)RKVL-Am, for Ni(II) binding. This site has been proposed mainly because of the potent inhibitory effect of Ni(II) on the acetylation of lysine residues near the histidine H(18), and also because of the accessibility of the H4 tail in the histone octamer. Combined potentiometric and spectroscopic studies showed that the histidine 18 acted as an anchoring binding site for metal ions in the peptide investigated. Comparison with the results for Cu(II) binding are also reported. The results allowed us to propose that the binding of Ni(II) is able to promote a secondary structure with organized side-chain orientation on the N-terminal tail of histone H4.

Published
2002
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