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340 results on '"Schilling, Joel D."'

1. Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

Author

Zhang, Xiangyu, Kapoor, Divya, Jeong, Se-Jin, Fappi, Alan, Stitham, Jeremiah, Shabrish, Vasavi, Sergin, Ismail, Yousif, Eman, Rodriguez-Velez, Astrid, Yeh, Yu-Sheng, Park, Arick, Yurdagul, Jr, Arif, Rom, Oren, Epelman, Slava, Schilling, Joel D., Sardiello, Marco, Diwan, Abhinav, Cho, Jaehyung, Stitziel, Nathan O., Javaheri, Ali, Lodhi, Irfan J., Mittendorfer, Bettina, and Razani, Babak

Published
2024
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2. Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Author

Knorr, Jana, Kaufmann, Benedikt, Inzaugarat, Maria Eugenia, Holtmann, Theresa Maria, Geisler, Lukas, Hundertmark, Jana, Kohlhepp, Marlene Sophia, Boosheri, Laela M, Chilin‐Fuentes, Daisy R, Birmingham, Amanda, Fisch, Kathleen M, Schilling, Joel D, Loosen, Sven H, Trautwein, Christian, Roderburg, Christoph, Demir, Münevver, Tacke, Frank, Hoffman, Hal M, Feldstein, Ariel E, and Wree, Alexander

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Liver Disease, Digestive Diseases, Nutrition, Chronic Liver Disease and Cirrhosis, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Oral and gastrointestinal, Mice, Animals, Inflammasomes, Hepatic Stellate Cells, Interleukin-18, NLR Family, Pyrin Domain-Containing 3 Protein, Liver Cirrhosis, Fibrosis, Carrier Proteins, Liver, Medical Biochemistry and Metabolomics, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background and aimsNucleotide-binding oligomerization domain-like receptor-family pyrin domain-containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis. Mechanisms and downstream signaling remain incompletely understood. Here, we studied the role of IL-18 in hepatic stellate cells (HSCs), and its impact on liver fibrosis.Approach and resultsWe observed significantly increased serum levels of IL-18 (128.4 pg/ml vs. 74.9 pg/ml) and IL-18 binding protein (BP; 46.50 ng/ml vs. 15.35 ng/ml) in patients with liver cirrhosis compared with healthy controls. Single cell RNA sequencing data showed that an immunoregulatory subset of murine HSCs highly expresses Il18 and Il18r1 . Treatment of cultured primary murine HSC with recombinant mouse IL-18 accelerated their transdifferentiation into myofibroblasts. In vivo , IL-18 receptor-deficient mice had reduced liver fibrosis in a model of fibrosis induced by HSC-specific NLRP3 overactivation. Whole liver RNA sequencing analysis from a murine model of severe NASH-induced fibrosis by feeding a choline-deficient, L-amino acid-defined, high fat diet showed that genes related to IL-18 and its downstream signaling were significantly upregulated, and Il18-/- mice receiving this diet for 10 weeks showed protection from fibrotic changes with decreased number of alpha smooth muscle actin-positive cells and collagen deposition. HSC activation triggered by NLRP3 inflammasome activation was abrogated when IL-18 signaling was blocked by its naturally occurring antagonist IL-18BP. Accordingly, we observed that the severe inflammatory phenotype associated with myeloid cell-specific NLRP3 gain-of-function was rescued by IL-18BP.ConclusionsOur study highlights the role of IL-18 in the development of liver fibrosis by its direct effect on HSC activation identifying IL-18 as a target to treat liver fibrosis.

Published
2023

3. Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

Author

Han, Jichang, Gallerand, Alexandre, Erlich, Emma C., Helmink, Beth A., Mair, Iris, Li, Xin, Eckhouse, Shaina R., Dimou, Francesca M., Shakhsheer, Baddr A., Phelps, Hannah M., Chan, Mandy M., Mintz, Rachel L., Lee, Daniel D., Schilling, Joel D., Finlay, Conor M., Allen, Judith E., Jakubzick, Claudia V., Else, Kathryn J., Onufer, Emily J., Zhang, Nan, and Randolph, Gwendalyn J.

Published
2024
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6. Steatosis drives monocyte-derived macrophage accumulation in human metabolic dysfunction-associated fatty liver disease

Author

Chan, Mandy M., Daemen, Sabine, Beals, Joseph W., Terekhova, Marina, Yang, Bin Q., Fu, Christina F., He, Li, Park, Arick C., Smith, Gordon I., Razani, Babak, Byrnes, Kathleen, Beatty, Wandy L., Eckhouse, Shaina R., Eagon, J. Christopher, Ferguson, Daniel, Finck, Brian N., Klein, Samuel, Artyomov, Maxim N., and Schilling, Joel D.

Published
2023
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17. Surgically implanted endovascular, microaxial left ventricular assist device: A single institution study

Author

Schumer, Erin M., primary, Bai, Yun Zhu, additional, Kotkar, Kunal D., additional, Masood, M. Faraz, additional, Itoh, Akinobu, additional, Schilling, Joel D., additional, Ewald, Gregory A., additional, Damiano, Marci S., additional, Fischer, Irene, additional, Kaneko, Tsuyoshi, additional, Damiano, Ralph J., additional, and Pawale, Amit, additional

Published
2023
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21. Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1β Signaling

Author

Zhang, Xiangyu, primary, Evans, Trent D., additional, Chen, Sunny, additional, Sergin, Ismail, additional, Stitham, Jeremiah, additional, Jeong, Se-Jin, additional, Rodriguez-Velez, Astrid, additional, Yeh, Yu-Sheng, additional, Park, Arick, additional, Jung, In-Hyuk, additional, Diwan, Abhinav, additional, Schilling, Joel D., additional, Rom, Oren, additional, Yurdagul, Arif, additional, Epelman, Slava, additional, Cho, Jaehyung, additional, Lodhi, Irfan J., additional, Mittendorfer, Bettina, additional, and Razani, Babak, additional

Published
2023
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28. Characterization of de novo malignancy after orthotopic heart transplantation: single-centre outcomes over 20 years.

Author

Bakir, Nadia H, Florea, Ioana B, Phillipps, Jordan, Schilling, Joel D, Damiano, Marci S, Ewald, Gregory A, Kotkar, Kunal D, Itoh, Akinobu, Damiano, Ralph J, Moon, Marc R, and Masood, Muhammad F

Subjects
SKIN cancer, HEART transplantation, MOHS surgery, BASAL cell carcinoma, SEARCH warrants (Law), SQUAMOUS cell carcinoma, HEART assist devices, GOVERNMENT insurance
Abstract

Open in new tab Download slide OBJECTIVES Malignancy is the leading cause of late mortality after orthotopic heart transplantation (OHT), and the burden of post-transplantation cancer is expected to rise in proportion to increased case volume following the 2018 heart allocation score change. In this report, we evaluated factors associated with de novo malignancy after OHT with a focus on skin and solid organ cancers. METHODS Patients who underwent OHT at our institution between 1999 and 2018 were retrospectively reviewed (n  = 488). Terminal outcomes of death and development of skin and/or solid organ malignancy were assessed as competing risks. Fine–Gray subdistribution hazards regression was used to evaluate the association between perioperative patient and donor characteristics and late-term malignancy outcomes. RESULTS By 1, 5 and 10 years, an estimated 2%, 17% and 27% of patients developed skin malignancy, while 1%, 5% and 12% of patients developed solid organ malignancy. On multivariable Fine–Gray regression, age [1.05 (1.03–1.08); P  <   0.001], government payer insurance [1.77 (1.20–2.59); P  =   0.006], family history of malignancy [1.66 (1.15–2.38); P  =   0.007] and metformin use [1.73 (1.15–2.59); P  =   0.008] were associated with increased risk of melanoma and basal or squamous cell carcinoma. Age [1.08 (1.04–1.12); P  <   0.001] and family history of malignancy [2.55 (1.43–4.56); P  =   0.002] were associated with an increased risk of solid organ cancer, most commonly prostate and lung cancer. CONCLUSIONS Vigilant cancer and immunosuppression surveillance is warranted in OHT recipients at late-term follow-up. The cumulative incidence of skin and solid organ malignancies increases temporally after transplantation, and key risk factors for the development of post-OHT malignancy warrant identification and routine monitoring. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Author

Daemen, Sabine, primary, Gainullina, Anastasiia, additional, Kalugotla, Gowri, additional, He, Li, additional, Chan, Mandy M., additional, Beals, Joseph W., additional, Liss, Kim H., additional, Klein, Samuel, additional, Feldstein, Ariel E., additional, Finck, Brian N., additional, Artyomov, Maxim N., additional, and Schilling, Joel D., additional

Published
2022
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33. Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Author

Knorr, Jana, primary, Kaufmann, Benedikt, additional, Inzaugarat, Maria Eugenia, additional, Holtmann, Theresa Maria, additional, Geisler, Lukas, additional, Hundertmark, Jana, additional, Kohlhepp, Marlene Sophia, additional, Boosheri, Laela M., additional, Chilin‐Fuentes, Daisy R., additional, Birmingham, Amanda, additional, Fisch, Kathleen M., additional, Schilling, Joel D., additional, Loosen, Sven H., additional, Trautwein, Christian, additional, Roderburg, Christoph, additional, Demir, Münevver, additional, Tacke, Frank, additional, Hoffman, Hal M., additional, Feldstein, Ariel E., additional, and Wree, Alexander, additional

Published
2022
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45. Derivation of extra-embryonic and intra-embryonic macrophage lineages from human pluripotent stem cells

Author

Bredemeyer, Andrea L., primary, Amrute, Junedh M., additional, Koenig, Andrew L., additional, Idol, Rachel A., additional, He, Li, additional, Luff, Stephanie A., additional, Dege, Carissa, additional, Leid, Jamison M., additional, Schilling, Joel D., additional, Hinson, J. Travis, additional, Dinauer, Mary C., additional, Sturgeon, Christopher M., additional, and Lavine, Kory J., additional

Published
2022
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