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2. The CARMENES search for exoplanets around M dwarfs - HD 147379b: A nearby Neptune in the temperate zone of an early-M dwarf

Author

Reiners, A., Ribas, I., Zechmeister, M., Caballero, J. A., Trifonov, T., Dreizler, S., Morales, J. C., Tal-Or, L., Lafarga, M., Quirrenbach, A., Amado, P. J., Kaminski, A., Jeffers, S. V., Aceituno, J., Béjar, V. J. S., Guàrdia, J., Guenther, E. W., Hagen, H. -J., Montes, D., Passegger, V. M., Seifert, W., Schweitzer, A., Cortés-Contreras, M., Abril, M., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Anglada-Escudé, G., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Bauer, F. F., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., del Burgo, C., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Czesla, S., Díez-Alonso, E., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Galera, V. Gómez, Hernández, J. I. González, González-Peinado, R., Grözinger, U., Grohnert, S., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, Th., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E. N., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Kürster, M., Labarga, F., Lamert, A., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., Launhardt, R., del Fresno, M. López, López-González, M. J., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Luque, R., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mathar, R. J., Mirabet, E., Moreno-Raya, M. E., Moya, A., Mundt, R., Nagel, E., Naranjo, V., Nortmann, L., Nowak, G., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reffert, S., Reinhart, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Rodríguez-López, C., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schiller, J., Schöfer, P., Solano, E., Stahl, O., Strachan, J. B. P., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tala, M., Tulloch, S. M., Ulbrich, R. -G., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We report on the first star discovered to host a planet detected by radial velocity (RV) observations obtained within the CARMENES survey for exoplanets around M dwarfs. HD 147379 ($V = 8.9$ mag, $M = 0.58 \pm 0.08$ M$_{\odot}$), a bright M0.0V star at a distance of 10.7 pc, is found to undergo periodic RV variations with a semi-amplitude of $K = 5.1\pm0.4$ m s$^{-1}$ and a period of $P = 86.54\pm0.06$ d. The RV signal is found in our CARMENES data, which were taken between 2016 and 2017, and is supported by HIRES/Keck observations that were obtained since 2000. The RV variations are interpreted as resulting from a planet of minimum mass $m_{\rm p}\sin{i} = 25 \pm 2$ M$_{\oplus}$, 1.5 times the mass of Neptune, with an orbital semi-major axis $a = 0.32$ au and low eccentricity ($e < 0.13$). HD 147379b is orbiting inside the temperate zone around the star, where water could exist in liquid form. The RV time-series and various spectroscopic indicators show additional hints of variations at an approximate period of 21.1d (and its first harmonic), which we attribute to the rotation period of the star., Comment: accepted for publication as A&A Letter

Published
2017
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3. The CARMENES search for exoplanets around M dwarfs: High-resolution optical and near-infrared spectroscopy of 324 survey stars

Author

Reiners, A., Zechmeister, M., Caballero, J. A., Ribas, I., Morales, J. C., Jeffers, S. V., Schöfer, P., Tal-Or, L., Quirrenbach, A., Amado, P. J., Kaminski, A., Seifert, W., Abril, M., Aceituno, J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Anglada-Escudé, G., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Bauer, F. F., Becerril, S., Béjar, V. J. S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., del Burgo, C., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dreizler, S., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Gómez, V., Galera, Hernández, J. I. González, González-Peinado, R., Grözinger, U., Grohnert, S., Guàrdia, J., Guenther, E. W., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hagen, H. -J., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, Th., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Kürster, M., Lafarga, M., Lamert, A., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., Launhardt, R., del Fresno, M. López, López-González, J., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Luque, R., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Maroto, D., Fernández, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mathar, R. J., Mirabet, E., Montes, D., Moreno-Raya, M. E., Moya, A., Mundt, R., Nagel, E., Naranjo, V., Nortmann, L., Nowak, G., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Passegger, V. M., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reffert, S., Reinhart, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Rodríguez-López, C., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schiller, J., Schweitzer, A., Solano, E., Stahl, O., Strachan, J. B. P., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tala, M., Trifonov, T., Tulloch, S. M., Ulbrich, R. G., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

The CARMENES radial velocity (RV) survey is observing 324 M dwarfs to search for any orbiting planets. In this paper, we present the survey sample by publishing one CARMENES spectrum for each M dwarf. These spectra cover the wavelength range 520--1710nm at a resolution of at least $R > 80,000$, and we measure its RV, H$\alpha$ emission, and projected rotation velocity. We present an atlas of high-resolution M-dwarf spectra and compare the spectra to atmospheric models. To quantify the RV precision that can be achieved in low-mass stars over the CARMENES wavelength range, we analyze our empirical information on the RV precision from more than 6500 observations. We compare our high-resolution M-dwarf spectra to atmospheric models where we determine the spectroscopic RV information content, $Q$, and signal-to-noise ratio. We find that for all M-type dwarfs, the highest RV precision can be reached in the wavelength range 700--900nm. Observations at longer wavelengths are equally precise only at the very latest spectral types (M8 and M9). We demonstrate that in this spectroscopic range, the large amount of absorption features compensates for the intrinsic faintness of an M7 star. To reach an RV precision of 1ms$^{-1}$ in very low mass M dwarfs at longer wavelengths likely requires the use of a 10m class telescope. For spectral types M6 and earlier, the combination of a red visual and a near-infrared spectrograph is ideal to search for low-mass planets and to distinguish between planets and stellar variability. At a 4m class telescope, an instrument like CARMENES has the potential to push the RV precision well below the typical jitter level of 3-4ms$^{-1}$., Comment: accepted for publication in A&A, 13 pages plus 40 pages spectral atlas, first 10 atlas pages are reduced in quality to fit arXiv size limit; one CARMENES spectrum for each of the 324 stars is published in electronic format at http://carmenes.cab.inta-csic.es/

Published
2017
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4. The CARMENES search for exoplanets around M dwarfs. First visual-channel radial-velocity measurements and orbital parameter updates of seven M-dwarf planetary systems

Author

Trifonov, T., Kürster, M., Zechmeister, M., Tal-Or, L., Caballero, J. A., Quirrenbach, A., Amado, P. J., Ribas, I., Reiners, A., Reffert, S., Dreizler, S., Hatzes, A. P., Kaminski, A., Launhardt, R., Henning, Th., Montes, D., Béjar, V. J. S., Mundt, R., Pavlov, A., Schmitt, J. H. M. M., Seifert, W., Morales, J. C., Nowak, G., Jeffers, S. V., Rodríguez-López, C., del Burgo, C., Anglada-Escudé, G., López-Santiago, J., Mathar, R. J., Eiff, M. Ammler-von, Guenther, E. W., Barrado, D., Hernández, J. I. González, Mancini, L., Stürmer, J., Abril, M., Aceituno, J., Alonso-Floriano, F. J., Antona, R., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Bauer, F. F., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Galera, V. Gómez, González-Peinado, R., Grözinger, U., Grohnert, S., Guàrdia, J., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hagen, H. -J., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Lafarga, M., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., del Fresno, M. López, López-González, J., López-Puertas, M., Salas, J. F. López, Luque, R., Madinabeitia, H. Magán, Mall, U., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mirabet, E., Moya, A., Moreno-Raya, M. E., Nagel, E., Naranjo, V., Nortmann, L., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Passegger, V. M., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reinhardt, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schiller, J., Schöfer, P., Schweitzer, A., Solano, E., Stahl, O., Strachan, J. B. P., Suárez, J. C., Tabernero, H. M., Tala, M., Tulloch, S. M., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context: The main goal of the CARMENES survey is to find Earth-mass planets around nearby M-dwarf stars. Seven M-dwarfs included in the CARMENES sample had been observed before with HIRES and HARPS and either were reported to have one short period planetary companion (GJ15A, GJ176, GJ436, GJ536 and GJ1148) or are multiple planetary systems (GJ581 and GJ876). Aims: We aim to report new precise optical radial velocity measurements for these planet hosts and test the overall capabilities of CARMENES. Methods: We combined our CARMENES precise Doppler measurements with those available from HIRES and HARPS and derived new orbital parameters for the systems. Bona-fide single planet systems are fitted with a Keplerian model. The multiple planet systems were analyzed using a self-consistent dynamical model and their best fit orbits were tested for long-term stability. Results: We confirm or provide supportive arguments for planets around all the investigated stars except for GJ15A, for which we find that the post-discovery HIRES data and our CARMENES data do not show a signal at 11.4 days. Although we cannot confirm the super-Earth planet GJ15Ab, we show evidence for a possible long-period ($P_{\rm c}$ = 7025$_{-629}^{+972}$ d) Saturn-mass ($m_{\rm c} \sin i$ = 51.8$_{-5.8}^{+5.5}M_\oplus$) planet around GJ15A. In addition, based on our CARMENES and HIRES data we discover a second planet around GJ1148, for which we estimate a period $P_{\rm c}$ = 532.6$_{-2.5}^{+4.1}$ d, eccentricity $e_{\rm c}$ = 0.34$_{-0.06}^{+0.05}$ and minimum mass $m_{\rm c} \sin i$ = 68.1$_{-2.2}^{+4.9}M_\oplus$. Conclusions: The CARMENES optical radial velocities have similar precision and overall scatter when compared to the Doppler measurements conducted with HARPS and HIRES. We conclude that CARMENES is an instrument that is up to the challenge of discovering rocky planets around low-mass stars., Comment: Accepted for publication in A&A, 24 pages, 16 figures, 14 tables

Published
2017
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5. EPS4.05 A multi-center, randomized, controlled trial on coaching and telemonitoring in patients with cystic fibrosis (conneCT CF): interim analysis

Author

Thee, S., primary, Stahl, M., additional, Sutharsan, S., additional, Fischer, R., additional, Ballmann, M., additional, Strasburg, S., additional, Tattersall-Wong, J., additional, Lauer, F., additional, Weitzel, J., additional, Ketter, A.-K., additional, Weber, W., additional, Kittlick, C., additional, Salathe, P., additional, Schiller, J., additional, Fuchs, C., additional, and Mall, M.A., additional

Published
2024
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6. “For a man to go to hospital, then that would be his last option”: A qualitative study exploring men’s experiences, perceptions and healthcare needs in the implementation of Universal Health Coverage in Kenya

Author

Mokua, Sharon N., primary, Ombogo, Lorraine, additional, Mathu, David, additional, Otambo, Prisca, additional, Nyandieka, Lilian, additional, Onteri, Stephen N., additional, Mbuka, Schiller J., additional, Kariuki, James, additional, Ahmed, Ismail, additional, Wanjihia, Violet, additional, Mutai, Joseph, additional, and Bukania, Zipporah, additional

Published
2024
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12. 135 A multicenter, randomized, controlled trial on coaching and telemonitoring in people with cystic fibrosis (conneCT CF): interim analysis

Author

Thee, S., primary, Stahl, M., additional, Sutharsan, S., additional, Fischer, R., additional, Ballmann, M., additional, Strasburg, S., additional, Tattersall-Wong, J., additional, Lauer, F., additional, Weitzel, J., additional, Ketter, A., additional, Weber, W., additional, Kittlick, C., additional, Salathe, P., additional, Schiller, J., additional, Puschner, F., additional, Amelung, V., additional, Jacobsen, T., additional, Fuchs, C., additional, and Mall, M., additional

Published
2023
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19. Perioperative Pembrolizumab for Early-Stage Non-Small-Cell Lung Cancer

Author

Heather, W, Moishe, L, Terufumi, K, Masahiro, T, Se-Hoon, L, Shugeng, G, Ke-Neng, C, Christophe, D, Margarita, M, Ekkehard, E, Gastón L, M, Olivier, B, Delvys, R, Jamie E, C, Silvia, N, Jing, Y, Steven M, K, Ayman, S, Spicer, D Marcelo Tatangelo, J, Flores, M, Pastor, A, Puig, J, Martinengo, G, Varela, M, Brocca, C, Wong, M, Hui, R, Dooms, C, Vansteenkiste, J, Demedts, I, Sibille, A, Surmont, V, Deschepper, K, Lambrechts, M, Dias, J, Rafael Martins De Marchi, P, Alves, G, Henrique Araujo, L, Matias, D, Chaves, F, Franke, F, Teixeira, C, Tabacof, J, Faria, L, Morbeck, I, Henrique Cronemberger, E, Lima, I, Sardenberg, R, de Paiva Junior, T, Dutra, C, Luiz Guimaraes, J, Begin, P, Langleben, A, Liu, G, Liberman, M, Spicer, J, Gao, S, Zhao, G, Jiang, T, Yan, X, Hu, J, Chen, J, Tan, L, Wang, Q, Li, S, Chen, K, Yang, Y, Bai, J, Ma, S, Chen, H, Chen, Q, Wang, W, Zhang, L, Zhu, Y, Vanakesa, T, Zasadny, X, Duchemann, B, Girard, N, Bylicki, O, Berard, H, Thiberville, L, Mennecier, B, Mazieres, J, Eigendorff, E, Bonnet, R, Fix, P, Reck, M, Rittmeyer, A, Reinacher-Schick, A, Wehler, T, Lehmann, M, Serke, M, Wesseler, C, Täuscher, D, Lang, S, Wermke, M, Grohe, C, Wirtz, H, Kollmeier, J, Ritgen, M, Mueller, A, Frohling, K, Vogel, G, Faehling, M, Cuffe, S, Collins, D, Delmonte, A, Gilli, M, Piantedosi, F, Ogliari, F, Bulotta, A, Gregorc, V, Gianni, L, Grisanti, S, Intagliata, S, Roca, E, Ferrari, V, Berruti, A, Cortinovis, D, Lo Russo, G, Ferrara, R, Garassino, M, Rita Migliorino, M, Novello, S, Santoro, A, Signorelli, D, Tsuboi, M, Okada, M, Kato, T, Nishio, W, Kuroda, H, Shimizu, J, Sakao, Y, Sugio, K, Horinouchi, H, Takamochi, K, Saji, H, Tanaka, F, Ikeda, N, Muto, S, Shio, Y, Suzuki, H, Hegmane, A, Cicenas, S, Zemaitis, M, Kek Pang, Y, Yew Heng, F, Leong Yu, K, Lowczak, A, Makles, K, Bryl, M, Zurawski, B, Pawlak, I, Han, J, Lee, S, Kim, J, Yong Shim, B, Cebotaru, C, Ganea, D, Scheusan, R, Ciurescu, I, Mazilu, L, Ungureanu, A, Gal, C, Ciubotaru, E, Iordan, I, Berceanu-Ion, R, Ciuleanu, T, Laktionov, K, Karaseva, N, Smagina, M, Luft, A, Afanasyev, S, Nesterova, A, Levchenko, E, Arkhipov, A, Fedenko, A, Ruff, P, Jacobs, C, Fourie, S, Carcereny, E, Calles Blanco, A, Rodriguez Abreu, D, Majem Tarruella, M, Bosch Barrera, J, Bernabe Caro, R, Nadal Alforja, E, Martnez Marti, A, Liao, B, Huang, H, Chiu, C, Wang, C, Tsai, C, Voitko, N, Kryzhanivska, A, Kolesnik, O, Levenko, O, Bondarenko, I, Trukhin, D, Ursol, G, Paramonov, V, Sokur, I, Khan, S, Arora, A, Goranov, B, Greystoke, A, Ahmed, S, Pope, T, O'Brien, M, Charu, V, Cobb, P, Costin, D, Weksler, B, Schumacher, L, Finley, G, Furqan, M, Gentzler, R, Misleh, J, Guarino, M, Halmos, B, Keresztes, R, Jain, K, Yan Lou, Y, Molina, J, Liu-Dumlao, T, Zhao, Q, Niu, J, Taysir Hammoud, Z, Rybkin, I, Cuevo, R, Fernando, H, Schiller, J, Srkalovic, G, Koontz, M, Stampleman, L, Anderson, I, Villaruz, L, Wang, S, Komiya, T, Jain, S, Starodub, A, Wakelee, H, Kishor Ganti, A, Ernani, V, Kristedja, T, O'Day, S, Radhi, S, Sangal, A, Duvivier, H, Rich, P, Kazmi, S, Pollock, T, Chaft, J, Rathnasabapathy, C, Savvides, P, Costas, K, Kaywin, P, Villalona-Calero, M, Alekshun, T, Rao, S, Siegel, R, Wakelee, Heather, Liberman, Moishe, Kato, Terufumi, Tsuboi, Masahiro, Lee, Se-Hoon, Gao, Shugeng, Chen, Ke-Neng, Dooms, Christophe, Majem, Margarita, Eigendorff, Ekkehard, Martinengo, Gastón L, Bylicki, Olivier, Rodríguez-Abreu, Delvys, Chaft, Jamie E, Novello, Silvia, Yang, Jing, Keller, Steven M, Samkari, Ayman, Jonathan D Marcelo Tatangelo, Marcos Flores, Andrea Pastor, Juan Puig, Gaston Martinengo, Mirta Varela, Carlos Brocca, Mark Wong, Rina Hui, Christophe Dooms, Johan Vansteenkiste, Ingel Demedts, Anne Sibille, Veerle Surmont, Koenraad Deschepper, Marc Lambrechts, Josiane Dias, Pedro Rafael Martins De Marchi, Gustavo Alves, Luiz Henrique Araujo, Danielli Matias, Fabio Chaves, Fabio Franke, Carlos Teixeira, Jacques Tabacof, Luiza Faria, Igor Morbeck, Eduardo Henrique Cronemberger, Iane Lima, Rodrigo Sardenberg, Tadeu de Paiva Junior, Carolina Dutra, Jose Luiz Guimaraes, Paul Begin, Adrian Langleben, Geoffrey Liu, Moishe Liberman, Jonathan Spicer, Shugeng Gao, Guofang Zhao, Tao Jiang, Xiaolong Yan, Jian Hu, Jun Chen, Lijie Tan, Qun Wang, Shanqing Li, Keneng Chen, Yue Yang, Jie Bai, Shaohua Ma, Haiquan Chen, Qixun Chen, Wenxiang Wang, Lanjun Zhang, Yuming Zhu, Tonu Vanakesa, Xavier Zasadny, Boris Duchemann, Nicolas Girard, Olivier Bylicki, Henri Berard, Luc Thiberville, Bertrand Mennecier, Julien Mazieres, Ekkehard Eigendorff, Reiner Bonnet, Peter Fix, Martin Reck, Achim Rittmeyer, Anke Reinacher-Schick, Thomas Wehler, Markus Lehmann, Monika Serke, Claas Wesseler, Dagmar Täuscher, Susanne Lang, Martin Wermke, Christian Grohe, Hubert Wirtz, Jens Kollmeier, Mathias Ritgen, Annette Mueller, Klaus-Peter Frohling, Gunther Vogel, Martin Faehling, Sinead Cuffe, Dearbhaile Collins, Angelo Delmonte, Marina Gilli, Francovito Piantedosi, Francesca Ogliari, Alessandra Bulotta, Vanesa Gregorc, Luca Gianni, Salvatore Grisanti, Salvatore Intagliata, Elisa Roca, Vittorio Ferrari, Alfredo Berruti, Diego Cortinovis, Giuseppe Lo Russo, Roberto Ferrara, Marina Garassino, Maria Rita Migliorino, Silvia Novello, Armando Santoro, Diego Signorelli, Masahiro Tsuboi, Morihito Okada, Terufumi Kato, Wataru Nishio, Hiroaki Kuroda, Junichi Shimizu, Yukinori Sakao, Kenji Sugio, Hidehito Horinouchi, Kazuya Takamochi, Hisashi Saji, Fumihiro Tanaka, Norihiko Ikeda, Satoshi Muto, Yutaka Shio, Hiroyuki Suzuki, Alinta Hegmane, Saulius Cicenas, Marius Zemaitis, Yong Kek Pang, Fook Yew Heng, Kong Leong Yu, Anna Lowczak, Krytsyna Makles, Maciej Bryl, Bogdan Zurawski, Ireneusz Pawlak, Ji-Youn Han, Se-Hoon Lee, Jhingook Kim, Byoung Yong Shim, Cristina Cebotaru, Doina Ganea, Roxana Scheusan, Ioana Ciurescu, Laura Mazilu, Andrei Ungureanu, Cristian Gal, Elena Ciubotaru, Ingrid Iordan, Radu Berceanu-Ion, Tudor Ciuleanu, Konstantin Laktionov, Nina Karaseva, Maria Smagina, Alexander Luft, Sergey Afanasyev, Alfiya Nesterova, Evgeny Levchenko, Alexander Arkhipov, Alexander Fedenko, Paul Ruff, Conrad Jacobs, Samuel Fourie, Enric Carcereny, Antonio Calles Blanco, Delvys Rodriguez Abreu, Margarita Majem Tarruella, Joaquim Bosch Barrera, Reyes Bernabe Caro, Ernest Nadal Alforja, Alex Martnez Marti, Bin-Chi Liao, Hsu-Ching Huang, Chao-Hua Chiu, Chin-Chou Wang, Chen-Liang Tsai, Nataliia Voitko, Anna Kryzhanivska, Olena Kolesnik, Oleh Levenko, Oleksii Kolesnik, Igor Bondarenko, Dmytro Trukhin, Grygorii Ursol, Viktor Paramonov, Iryna Sokur, Sarah Khan, Arvind Arora, Bojidar Goranov, Alastair Greystoke, Samreen Ahmed, Tony Pope, Mary O'Brien, Veena Charu, Patrick Cobb, Dan Costin, Benny Weksler, Lana Schumacher, Gene Finley, Muhammad Furqan, Ryan Gentzler, Jamal Misleh, Michael Guarino, Balazs Halmos, Roger Keresztes, Kirti Jain, Yan Yan Lou, Julian Molina, Theresa Liu-Dumlao, Qing Zhao, Jiaxin Niu, Zane Taysir Hammoud, Igor Rybkin, Raymund Cuevo, Hiran Fernando, Joan Schiller, Gordan Srkalovic, Michael Koontz, Laura Stampleman, Ian Anderson, Liza Villaruz, Sarah Wang, Takefumi Komiya, Sushil Jain, Alexander Starodub, Heather Wakelee, Apar Kishor Ganti, Vinicius Ernani, Timothy Kristedja, Steven O'Day, Saba Radhi, Ashish Sangal, Herbert Duvivier, Patricia Rich, Shayma Kazmi, Theodore Pollock, Jamie Chaft, Chenthilmurugan Rathnasabapathy, Panayiotis Savvides, Kimberly Costas, Paul Kaywin, Miguel Villalona-Calero, Todd Alekshun, Kevin Chen, Suman Rao, Robert Siegel, Heather, W, Moishe, L, Terufumi, K, Masahiro, T, Se-Hoon, L, Shugeng, G, Ke-Neng, C, Christophe, D, Margarita, M, Ekkehard, E, Gastón L, M, Olivier, B, Delvys, R, Jamie E, C, Silvia, N, Jing, Y, Steven M, K, Ayman, S, Spicer, D Marcelo Tatangelo, J, Flores, M, Pastor, A, Puig, J, Martinengo, G, Varela, M, Brocca, C, Wong, M, Hui, R, Dooms, C, Vansteenkiste, J, Demedts, I, Sibille, A, Surmont, V, Deschepper, K, Lambrechts, M, Dias, J, Rafael Martins De Marchi, P, Alves, G, Henrique Araujo, L, Matias, D, Chaves, F, Franke, F, Teixeira, C, Tabacof, J, Faria, L, Morbeck, I, Henrique Cronemberger, E, Lima, I, Sardenberg, R, de Paiva Junior, T, Dutra, C, Luiz Guimaraes, J, Begin, P, Langleben, A, Liu, G, Liberman, M, Spicer, J, Gao, S, Zhao, G, Jiang, T, Yan, X, Hu, J, Chen, J, Tan, L, Wang, Q, Li, S, Chen, K, Yang, Y, Bai, J, Ma, S, Chen, H, Chen, Q, Wang, W, Zhang, L, Zhu, Y, Vanakesa, T, Zasadny, X, Duchemann, B, Girard, N, Bylicki, O, Berard, H, Thiberville, L, Mennecier, B, Mazieres, J, Eigendorff, E, Bonnet, R, Fix, P, Reck, M, Rittmeyer, A, Reinacher-Schick, A, Wehler, T, Lehmann, M, Serke, M, Wesseler, C, Täuscher, D, Lang, S, Wermke, M, Grohe, C, Wirtz, H, Kollmeier, J, Ritgen, M, Mueller, A, Frohling, K, Vogel, G, Faehling, M, Cuffe, S, Collins, D, Delmonte, A, Gilli, M, Piantedosi, F, Ogliari, F, Bulotta, A, Gregorc, V, Gianni, L, Grisanti, S, Intagliata, S, Roca, E, Ferrari, V, Berruti, A, Cortinovis, D, Lo Russo, G, Ferrara, R, Garassino, M, Rita Migliorino, M, Novello, S, Santoro, A, Signorelli, D, Tsuboi, M, Okada, M, Kato, T, Nishio, W, Kuroda, H, Shimizu, J, Sakao, Y, Sugio, K, Horinouchi, H, Takamochi, K, Saji, H, Tanaka, F, Ikeda, N, Muto, S, Shio, Y, Suzuki, H, Hegmane, A, Cicenas, S, Zemaitis, M, Kek Pang, Y, Yew Heng, F, Leong Yu, K, Lowczak, A, Makles, K, Bryl, M, Zurawski, B, Pawlak, I, Han, J, Lee, S, Kim, J, Yong Shim, B, Cebotaru, C, Ganea, D, Scheusan, R, Ciurescu, I, Mazilu, L, Ungureanu, A, Gal, C, Ciubotaru, E, Iordan, I, Berceanu-Ion, R, Ciuleanu, T, Laktionov, K, Karaseva, N, Smagina, M, Luft, A, Afanasyev, S, Nesterova, A, Levchenko, E, Arkhipov, A, Fedenko, A, Ruff, P, Jacobs, C, Fourie, S, Carcereny, E, Calles Blanco, A, Rodriguez Abreu, D, Majem Tarruella, M, Bosch Barrera, J, Bernabe Caro, R, Nadal Alforja, E, Martnez Marti, A, Liao, B, Huang, H, Chiu, C, Wang, C, Tsai, C, Voitko, N, Kryzhanivska, A, Kolesnik, O, Levenko, O, Bondarenko, I, Trukhin, D, Ursol, G, Paramonov, V, Sokur, I, Khan, S, Arora, A, Goranov, B, Greystoke, A, Ahmed, S, Pope, T, O'Brien, M, Charu, V, Cobb, P, Costin, D, Weksler, B, Schumacher, L, Finley, G, Furqan, M, Gentzler, R, Misleh, J, Guarino, M, Halmos, B, Keresztes, R, Jain, K, Yan Lou, Y, Molina, J, Liu-Dumlao, T, Zhao, Q, Niu, J, Taysir Hammoud, Z, Rybkin, I, Cuevo, R, Fernando, H, Schiller, J, Srkalovic, G, Koontz, M, Stampleman, L, Anderson, I, Villaruz, L, Wang, S, Komiya, T, Jain, S, Starodub, A, Wakelee, H, Kishor Ganti, A, Ernani, V, Kristedja, T, O'Day, S, Radhi, S, Sangal, A, Duvivier, H, Rich, P, Kazmi, S, Pollock, T, Chaft, J, Rathnasabapathy, C, Savvides, P, Costas, K, Kaywin, P, Villalona-Calero, M, Alekshun, T, Rao, S, Siegel, R, Wakelee, Heather, Liberman, Moishe, Kato, Terufumi, Tsuboi, Masahiro, Lee, Se-Hoon, Gao, Shugeng, Chen, Ke-Neng, Dooms, Christophe, Majem, Margarita, Eigendorff, Ekkehard, Martinengo, Gastón L, Bylicki, Olivier, Rodríguez-Abreu, Delvys, Chaft, Jamie E, Novello, Silvia, Yang, Jing, Keller, Steven M, Samkari, Ayman, Jonathan D Marcelo Tatangelo, Marcos Flores, Andrea Pastor, Juan Puig, Gaston Martinengo, Mirta Varela, Carlos Brocca, Mark Wong, Rina Hui, Christophe Dooms, Johan Vansteenkiste, Ingel Demedts, Anne Sibille, Veerle Surmont, Koenraad Deschepper, Marc Lambrechts, Josiane Dias, Pedro Rafael Martins De Marchi, Gustavo Alves, Luiz Henrique Araujo, Danielli Matias, Fabio Chaves, Fabio Franke, Carlos Teixeira, Jacques Tabacof, Luiza Faria, Igor Morbeck, Eduardo Henrique Cronemberger, Iane Lima, Rodrigo Sardenberg, Tadeu de Paiva Junior, Carolina Dutra, Jose Luiz Guimaraes, Paul Begin, Adrian Langleben, Geoffrey Liu, Moishe Liberman, Jonathan Spicer, Shugeng Gao, Guofang Zhao, Tao Jiang, Xiaolong Yan, Jian Hu, Jun Chen, Lijie Tan, Qun Wang, Shanqing Li, Keneng Chen, Yue Yang, Jie Bai, Shaohua Ma, Haiquan Chen, Qixun Chen, Wenxiang Wang, Lanjun Zhang, Yuming Zhu, Tonu Vanakesa, Xavier Zasadny, Boris Duchemann, Nicolas Girard, Olivier Bylicki, Henri Berard, Luc Thiberville, Bertrand Mennecier, Julien Mazieres, Ekkehard Eigendorff, Reiner Bonnet, Peter Fix, Martin Reck, Achim Rittmeyer, Anke Reinacher-Schick, Thomas Wehler, Markus Lehmann, Monika Serke, Claas Wesseler, Dagmar Täuscher, Susanne Lang, Martin Wermke, Christian Grohe, Hubert Wirtz, Jens Kollmeier, Mathias Ritgen, Annette Mueller, Klaus-Peter Frohling, Gunther Vogel, Martin Faehling, Sinead Cuffe, Dearbhaile Collins, Angelo Delmonte, Marina Gilli, Francovito Piantedosi, Francesca Ogliari, Alessandra Bulotta, Vanesa Gregorc, Luca Gianni, Salvatore Grisanti, Salvatore Intagliata, Elisa Roca, Vittorio Ferrari, Alfredo Berruti, Diego Cortinovis, Giuseppe Lo Russo, Roberto Ferrara, Marina Garassino, Maria Rita Migliorino, Silvia Novello, Armando Santoro, Diego Signorelli, Masahiro Tsuboi, Morihito Okada, Terufumi Kato, Wataru Nishio, Hiroaki Kuroda, Junichi Shimizu, Yukinori Sakao, Kenji Sugio, Hidehito Horinouchi, Kazuya Takamochi, Hisashi Saji, Fumihiro Tanaka, Norihiko Ikeda, Satoshi Muto, Yutaka Shio, Hiroyuki Suzuki, Alinta Hegmane, Saulius Cicenas, Marius Zemaitis, Yong Kek Pang, Fook Yew Heng, Kong Leong Yu, Anna Lowczak, Krytsyna Makles, Maciej Bryl, Bogdan Zurawski, Ireneusz Pawlak, Ji-Youn Han, Se-Hoon Lee, Jhingook Kim, Byoung Yong Shim, Cristina Cebotaru, Doina Ganea, Roxana Scheusan, Ioana Ciurescu, Laura Mazilu, Andrei Ungureanu, Cristian Gal, Elena Ciubotaru, Ingrid Iordan, Radu Berceanu-Ion, Tudor Ciuleanu, Konstantin Laktionov, Nina Karaseva, Maria Smagina, Alexander Luft, Sergey Afanasyev, Alfiya Nesterova, Evgeny Levchenko, Alexander Arkhipov, Alexander Fedenko, Paul Ruff, Conrad Jacobs, Samuel Fourie, Enric Carcereny, Antonio Calles Blanco, Delvys Rodriguez Abreu, Margarita Majem Tarruella, Joaquim Bosch Barrera, Reyes Bernabe Caro, Ernest Nadal Alforja, Alex Martnez Marti, Bin-Chi Liao, Hsu-Ching Huang, Chao-Hua Chiu, Chin-Chou Wang, Chen-Liang Tsai, Nataliia Voitko, Anna Kryzhanivska, Olena Kolesnik, Oleh Levenko, Oleksii Kolesnik, Igor Bondarenko, Dmytro Trukhin, Grygorii Ursol, Viktor Paramonov, Iryna Sokur, Sarah Khan, Arvind Arora, Bojidar Goranov, Alastair Greystoke, Samreen Ahmed, Tony Pope, Mary O'Brien, Veena Charu, Patrick Cobb, Dan Costin, Benny Weksler, Lana Schumacher, Gene Finley, Muhammad Furqan, Ryan Gentzler, Jamal Misleh, Michael Guarino, Balazs Halmos, Roger Keresztes, Kirti Jain, Yan Yan Lou, Julian Molina, Theresa Liu-Dumlao, Qing Zhao, Jiaxin Niu, Zane Taysir Hammoud, Igor Rybkin, Raymund Cuevo, Hiran Fernando, Joan Schiller, Gordan Srkalovic, Michael Koontz, Laura Stampleman, Ian Anderson, Liza Villaruz, Sarah Wang, Takefumi Komiya, Sushil Jain, Alexander Starodub, Heather Wakelee, Apar Kishor Ganti, Vinicius Ernani, Timothy Kristedja, Steven O'Day, Saba Radhi, Ashish Sangal, Herbert Duvivier, Patricia Rich, Shayma Kazmi, Theodore Pollock, Jamie Chaft, Chenthilmurugan Rathnasabapathy, Panayiotis Savvides, Kimberly Costas, Paul Kaywin, Miguel Villalona-Calero, Todd Alekshun, Kevin Chen, Suman Rao, and Robert Siegel

Abstract

BACKGROUND Among patients with resectable early-stage non-small-cell lung cancer (NSCLC), a perioperative approach that includes both neoadjuvant and adjuvant immune checkpoint inhibition may provide benefit beyond either approach alone. METHODS We conducted a randomized, double-blind, phase 3 trial to evaluate perioperative pembrolizumab in patients with early-stage NSCLC. Participants with resectable stage II, IIIA, or IIIB (N2 stage) NSCLC were assigned in a 1:1 ratio to receive neoadjuvant pembrolizumab (200 mg) or placebo once every 3 weeks, each of which was given with cisplatin-based chemotherapy for 4 cycles, followed by surgery and adjuvant pembrolizumab (200 mg) or placebo once every 3 weeks for up to 13 cycles. The dual primary end points were event-free survival (the time from randomization to the first occurrence of local progression that precluded the planned surgery, unresectable tumor, progression or recurrence, or death) and overall survival. Secondary end points included major pathological response, pathological complete response, and safety. RESULTS A total of 397 participants were assigned to the pembrolizumab group, and 400 to the placebo group. At the prespecified first interim analysis, the median follow-up was 25.2 months. Event-free survival at 24 months was 62.4% in the pembrolizumab group and 40.6% in the placebo group (hazard ratio for progression, recurrence, or death, 0.58; 95% confidence interval [CI], 0.46 to 0.72; P<0.001). The estimated 24-month overall survival was 80.9% in the pembrolizumab group and 77.6% in the placebo group (P = 0.02, which did not meet the significance criterion). A major pathological response occurred in 30.2% of the participants in the pembrolizumab group and in 11.0% of those in the placebo group (difference, 19.2 percentage points; 95% CI, 13.9 to 24.7; P<0.0001; threshold, P = 0.0001), and a pathological complete response occurred in 18.1% and 4.0%, respectively (difference, 14.2 percentage points

Published
2023

21. Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling

Author

Schiller, J., Laube, E., https://orcid.org/0000-0002-1096-5178, Wittig, I., Kühlbrandt, W., https://orcid.org/0000-0002-2013-4810, Vonck, J., https://orcid.org/0000-0001-5659-8863, and Zickermann, V.

Abstract

Respiratory complex I is a ~1-MDa proton pump in mitochondria. Its structure has been revealed in great detail, but the structural basis of its assembly, in humans involving at least 15 assembly factors, is essentially unknown. We determined cryo–electron microscopy structures of assembly intermediates associated with assembly factor NDUFAF1 in a yeast model system. Subunits ND2 and NDUFC2 together with assembly factors NDUFAF1 and CIA84 form the nucleation point of the NDUFAF1-dependent assembly pathway. Unexpectedly, the cardiolipin remodeling enzyme tafazzin is an integral component of this core complex. In a later intermediate, all 12 subunits of the proximal proton pump module have assembled. NDUFAF1 locks the central ND3 subunit in an assembly-competent conformation, and major rearrangements of central subunits are required for complex I maturation.

Published
2022

26. Perimetry

Author

Schiefer, U., Schiller, J., Hart, W., Schiefer, Ulrich, editor, Wilhelm, Helmut, editor, and Hart, William, editor

Published
2007
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28. P2.08-09 Adaptation of Empathic Communication Skills Training for Oncology Care Providers to Reduce Lung Cancer Stigma

Author

Ostroff, J., primary, Banerjee, S., additional, Malling, C., additional, Parker, P., additional, Carter-Harris, L., additional, Emard, N., additional, Shen, M., additional, Williamson, T., additional, Hamann, H., additional, Bylund, C., additional, Studts, J., additional, Rigney, M., additional, King, J.C., additional, Fathi, J., additional, Feldman, J., additional, Pantelas, J., additional, Schiller, J., additional, Borondy-Kitts, A., additional, Kazerooni, E., additional, Mullet, T., additional, Rosenthal, L., additional, and Durden, K., additional

Published
2022
Full Text
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30. Eva und die Weisheit. Der menschliche Weg zur Erkenntnis gemäss Gen 3,6

Author

Eder, Sigrid, Langer, Gerhard, Müllner, Ilse, Schiller, Johannes, Taschl-Erber, Andrea, Eder, S ( Sigrid ), Langer, G ( Gerhard ), Müllner, I ( Ilse ), Schiller, J ( Johannes ), Taschl-Erber, A ( Andrea ), Schmid, Konrad; https://orcid.org/0000-0002-8968-2604, Eder, Sigrid, Langer, Gerhard, Müllner, Ilse, Schiller, Johannes, Taschl-Erber, Andrea, Eder, S ( Sigrid ), Langer, G ( Gerhard ), Müllner, I ( Ilse ), Schiller, J ( Johannes ), Taschl-Erber, A ( Andrea ), and Schmid, Konrad; https://orcid.org/0000-0002-8968-2604

Published
2022

31. Adenosine receptor A2a blockade by caffeine increases IFN-gamma production in Th1 cells from patients with rheumatoid arthritis

Author

Gloyer, L., Golumba-Nagy, V, Meyer, A., Yan, S., Schiller, J., Breuninger, M., Jochimsen, D., Kofler, D. M., Gloyer, L., Golumba-Nagy, V, Meyer, A., Yan, S., Schiller, J., Breuninger, M., Jochimsen, D., and Kofler, D. M.

Abstract

Objective Studies indicate that caffeine uptake may be a risk factor for rheumatoid arthritis (RA), but a definitive link between caffeine consumption and RA has not been established. This study aimed to investigate the interplay between caffeine, adenosine receptor A2a, and interferon-gamma (IFN-gamma) production in CD4(+) T cells from RA patients. Method Peripheral blood mononuclear cells were obtained from the peripheral blood of healthy individuals and patients with RA. CD4(+) T cells were isolated using the magnetic activated cell sorting technique and cultured in vitro with caffeine or mock control. In addition, adenosine was used as a competitive inhibitor of caffeine. After 48 h, expression of IFN-gamma and interleukin-17 (IL-17) was analysed by flow cytometry. Ex vivo expression levels of adenosine receptor A2a were also assessed. Results Caffeine promoted IFN-gamma production in Th1 cells in vitro. Significantly higher concentrations of caffeine were required to increase IFN-gamma levels in Th1 cells from healthy individuals compared to Th1 cells from patients with RA. Moreover, ex vivo levels of adenosine receptor A2a expression on CD4(+) T cells were significantly higher in RA than in healthy individuals. Caffeine-driven IFN-gamma production was completely reversed by adenosine, a competitive agonist of adenosine receptor A2a. In contrast to IFN-gamma, production of IL-17 was not affected by caffeine. Conclusion Caffeine promotes IFN-gamma production in Th1 cells from RA patients in vitro by competitive inhibition of adenosine receptor A2a. Excessive coffee consumption could contribute to T-cell activation and inflammation in RA.

Published
2022

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