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PURPOSE. To measure vitreous levels of solubleintercellular adhesion molecule-1 (sICAM-1) and soluble vascular cellularadhesion molecule-1 (sVCAM-1) in the eyes of patients with retinal detachment(RD) due to proliferative diabetic retinopathy (PDR) or proliferative vitreoretinopathy(PVR) and to determine whether the levels of these mediators correlated withclinical parameters of disease. METHODS. Undiluted vitreous specimens were collected from 50 eyes of 48patients undergoing vitrectomy for traction RD due to PDR (21 specimens) andrecurrent RD due to PVR (19 specimens). Control vitreous specimens were obtainedfrom patients undergoing macular hole repair (10 specimens). The levels ofsICAM-1 and sVCAM-1 were measured in each sample by specific enzyme-linkedimmunoadsorbent assays. RESULTS. Vitreous levels of sICAM-1 were significantly increased in vitreousspecimens from both PVR (median ± SD; 12.0 ± 76.3 ng/ml; P <0.01) and PDR (8.4 ± 24.0 ng/ml; P < 0.01) when compared to vitreousfrom eyes with macular holes (0.3 ± 4.2 ng/ml). Vitreous levels ofsVCAM-1 were significantly increased in both PVR (36.5 ± 255.2 ng/ml;P < 0.001) and PDR (26.2 ± 93.5 ng/ml; P < 0.01) when comparedto control vitreous (17.7 ± 7.8 ng/ml). The vitreous levels of sICAM-1were higher in cases of PDR which developed recurrent proliferative disease(P < 0.01) and recurrent RD (P = 0.01), whereas the levels of sICAM-1 inPVR and sVCAM-1 in PDR and PVR did not significantly correlate with theseclinical parameters. CONCLUSIONS. Soluble forms of ICAM-1 and VCAM-1 are increased in the vitreouscavity of patients with RD due to PDR or PVR, reflecting the inflammatorynature of these conditions and suggesting a possible role for these mediatorsin the pathogenesis of proliferative retinal disease. The vitreous levelsof these sCAMs at the time of surgery may serve as a marker of inflammation,but their specific levels do not predict the likelihood of recurrent prolife... [ABSTRACT FROM AUTHOR]

Objective: To determine the effect of lens status upon the anatomic and visual results in primary diabetic vitrectomy., Design: Retrospective, comparative, consecutive case series., Participants: One hundred two eyes of 85 patients with proliferative diabetic retinopathy and its complications that underwent primary vitrectomy., Methods: The eyes that remained phakic after vitrectomy were compared with the eyes that were either aphakic or pseudophakic (nonphakic) postoperatively., Main Outcome Measures: Intraoperative and postoperative complications, vitreoretinal reoperation rate, and ultimate anatomic and visual success with at least 6 months' follow-up., Results: Preoperatively, 72 eyes were phakic, and 30 were aphakic (n = 1) or pseudophakic (n = 29). During vitrectomy, 1 eye underwent lensectomy and 12 eyes underwent phacoemulsification with lens implantation. Postoperatively, 59 eyes were phakic and 43 eyes were nonphakic. The vitreoretinal reoperation rate was significantly higher (P = 0.04) for the phakic group (28.8%) than for the nonphakic group (11.6%). Rubeosis iridis developed in 3 phakic eyes and no nonphakic eyes (P = 0.26). Intraoperative complications were similar in the phakic and nonphakic groups (P = 0.40). Postoperative complications such as rhegmatogenous retinal detachment (P = 0.39), nonclearing vitreous hemorrhage (P = 0.07), and anterior chamber complications (P = 0.60) were also similar. Visual acuity improved by at least 0.2 logarithm of the minimum angle of resolution units in 76.2% of the phakic eyes and 86.0% of the nonphakic eyes (P = 0.22)., Conclusions: Eyes that were phakic after primary diabetic vitrectomy had a significantly higher subsequent vitreoretinal reoperation rate when compared with nonphakic eyes, suggesting that diabetic eyes are less likely to require additional vitreoretinal surgery if they are rendered nonphakic before or during vitrectomy.

Case Report: Optic disc pit is an embryological malformation of the optic nerve that occurs in less than one in 10,000 people. It is 10%-15% bilateral, and 25% to 70% of patients develop a neurosensory macular detachment within the 2nd to 4th decade., Comments: We report a case of unilateral optic disc pit maculopathy 2 months after laser-assisted in situ keratomileusis (LASIK) revision.

The etiology, diagnosis, sequelae, and management of ocular hypotony are discussed in this review. Hypotony from decreased production of aqueous is often due to inflammation, medications, or proliferative vitreoretinopathy. Hypotony from aqueous loss may be external, such as following surgery or trauma, or internal, as in cyclodialysis cleft or retinal detachment. Treatment of hypotony is most effective if the underlying cause can be addressed, either surgically or medically. Marked improvement in vision may be achieved if hypotony is reversed.