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2. Coded masks for imaging of neutrino events

Author

Andreotti, M., Bernardini, P., Bersani, A., Bertolucci, S., Biagi, S., Branca, A., Brizzolari, C., Brunetti, G., Cagnoli, I., Calabrese, R., Caminata, A., Campani, A., Carniti, P., Cataldo, R., Cattadori, C., Cherubini, S., Cicero, V., Citterio, M., Copello, S., Cova, P., Morales, E. Cristaldo, Davini, S., Delmonte, N., De Matteis, G., Di Domizio, S., Di Noto, L., Distefano, C., Giammaria, T., Guarise, M., Falcone, A., Ferraro, F., Fiorini, M., Gallice, N., Gotti, C., Guerzoni, M., Iliescu, M. A., Ingratta, G., Lazzaroni, M., Lax, I., Laurenti, G., Leaci, A., Luppi, E., Martina, L., Mauri, N., Minotti, A., Moggi, N., Montagna, E., Montanari, A., Montanino, D., Pallavicini, M., Panareo, M., Parozzi, E. G., Pasqualini, L., Patrizii, L., Pessina, G., Poppi, F., Pozzato, M., Pia, V., Riboldi, S., Riccobene, G., Sala, P., Sapienza, P., Schifano, F., Sirri, G., Spanu, M., Stanco, L., Surdo, A., Taibi, A., Tenti, M., Terranova, F., Testera, G., Tomassetti, L., Torti, M., Tosi, N., Travaglini, R., Uboldi, L., Vicenzi, M., Zani, A., and Zucchelli, S.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The capture of scintillation light emitted by liquid Argon and Xenon under molecular excitations by charged particles is still a challenging task. Here we present a first attempt to design a device able to grab sufficiently high luminosity in order to reconstruct the path of ionizing particles. This preliminary study is based on the use of masks to encode the light signal combined with single-photon detectors. In this respect, the proposed system is able to detect tracks over focal distances of about tens of centimeters. From numerical simulations it emerges that it is possible to successfully decode and recognize signals, even complex, with a relatively limited number of acquisition channels. Such innovative technique can be very fruitful in a new generation of detectors devoted to neutrino physics and dark matter search. Indeed the introduction of coded masks combined with SiPM detectors is proposed for a liquid-Argon target in the Near Detector of the DUNE experiment.

Published
2021
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3. Cryogenic characterization of Hamamatsu HWB MPPCs for the DUNE photon detection system

Author

Andreotti, M, Bertolucci, S, Branca, A, Brizzolari, C, Brunetti, G, Calabrese, R, Carniti, P, Casazza, D, Cattadori, C, Calvo, E, Cervera, A, Chiozzi, S, Cicero, V, Cotta Ramusino, A, Cristaldo Morales, E, Cuesta, C, D'Amico, R, De la Torre, A, Delgado Gonzalez, M, Di Capua, F, Di Ferdinando, D, Dyshkant, A, Eads, M, Falcone, A, Fialova, E, Filip, P, Fiorillo, G, Fiorini, M, Francis, K, Galizzi, F, Gallice, N, Garcia-Gamez, D, García-Peris, M, Giammaria, T, Gil-Botella, I, Giugliano, C, Gotti, C, Guarise, M, Guffanti, D, Kovalcuk, M, Lax, I, Lazzaroni, M, Lokajicek, M, Luppi, E, Manthey, S, Martin-Albo, J, Mauri, N, Meazza, L, Minotti, A, Moggi, N, Montagna, E, Montanari, A, Neri, I, Nicolas-Arnaldos, F, Palomares, C, Pasqualini, L, Patrizii, L, Pérez-Molina, L, Pessina, G, Pia, V, Poppi, F, Pozzato, M, Querol, M, Rocabado, J, Saadana, A, Sala, P, Sanchez-Castillo, A, Sanchez-Lucas, P, Schifano, F, Sirri, G, Smolik, J, Spanu, M, Terranova, F, Tenti, M, Tomassetti, L, Torti, M, Tosi, N, Verdugo de Osa, A, Vieira de Souza, H, Zalesak, J, Zamorano, B, Zani, A, Zucchelli, S, Zuklin, J, Zutshi, V, Andreotti, M., Bertolucci, S., Branca, A., Brizzolari, C., Brunetti, G., Calabrese, R., Carniti, P., Casazza, D., Cattadori, C., Calvo, E., Cervera, A., Chiozzi, S., Cicero, V., Cotta Ramusino, A., Cristaldo Morales, E., Cuesta, C., D'Amico, R., De la Torre, A., Delgado Gonzalez, M., Di Capua, F., Di Ferdinando, D., Dyshkant, A., Eads, M., Falcone, A., Fialova, E., Filip, P., Fiorillo, G., Fiorini, M., Francis, K., Galizzi, F., Gallice, N., Garcia-Gamez, D., García-Peris, M. Á., Giammaria, T., Gil-Botella, I., Giugliano, C., Gotti, C., Guarise, M., Guffanti, D., Kovalcuk, M., Lax, I., Lazzaroni, M., Lokajicek, M., Luppi, E., Manthey, S., Martin-Albo, J., Mauri, N., Meazza, L., Minotti, A., Moggi, N., Montagna, E., Montanari, A., Neri, I., Nicolas-Arnaldos, F. J., Palomares, C., Pasqualini, L., Patrizii, L., Pérez-Molina, L., Pessina, G., Pia, V., Poppi, F., Pozzato, M., Querol, M., Rocabado, J., Saadana, A., Sala, P., Sanchez-Castillo, A., Sanchez-Lucas, P., Schifano, F. S., Sirri, G., Smolik, J., Spanu, M., Terranova, F., Tenti, M., Tomassetti, L., Torti, M., Tosi, N., Verdugo de Osa, A., Vieira de Souza, H., Zalesak, J., Zamorano, B., Zani, A., Zucchelli, S., Zuklin, J., Zutshi, V., Andreotti, M, Bertolucci, S, Branca, A, Brizzolari, C, Brunetti, G, Calabrese, R, Carniti, P, Casazza, D, Cattadori, C, Calvo, E, Cervera, A, Chiozzi, S, Cicero, V, Cotta Ramusino, A, Cristaldo Morales, E, Cuesta, C, D'Amico, R, De la Torre, A, Delgado Gonzalez, M, Di Capua, F, Di Ferdinando, D, Dyshkant, A, Eads, M, Falcone, A, Fialova, E, Filip, P, Fiorillo, G, Fiorini, M, Francis, K, Galizzi, F, Gallice, N, Garcia-Gamez, D, García-Peris, M, Giammaria, T, Gil-Botella, I, Giugliano, C, Gotti, C, Guarise, M, Guffanti, D, Kovalcuk, M, Lax, I, Lazzaroni, M, Lokajicek, M, Luppi, E, Manthey, S, Martin-Albo, J, Mauri, N, Meazza, L, Minotti, A, Moggi, N, Montagna, E, Montanari, A, Neri, I, Nicolas-Arnaldos, F, Palomares, C, Pasqualini, L, Patrizii, L, Pérez-Molina, L, Pessina, G, Pia, V, Poppi, F, Pozzato, M, Querol, M, Rocabado, J, Saadana, A, Sala, P, Sanchez-Castillo, A, Sanchez-Lucas, P, Schifano, F, Sirri, G, Smolik, J, Spanu, M, Terranova, F, Tenti, M, Tomassetti, L, Torti, M, Tosi, N, Verdugo de Osa, A, Vieira de Souza, H, Zalesak, J, Zamorano, B, Zani, A, Zucchelli, S, Zuklin, J, Zutshi, V, Andreotti, M., Bertolucci, S., Branca, A., Brizzolari, C., Brunetti, G., Calabrese, R., Carniti, P., Casazza, D., Cattadori, C., Calvo, E., Cervera, A., Chiozzi, S., Cicero, V., Cotta Ramusino, A., Cristaldo Morales, E., Cuesta, C., D'Amico, R., De la Torre, A., Delgado Gonzalez, M., Di Capua, F., Di Ferdinando, D., Dyshkant, A., Eads, M., Falcone, A., Fialova, E., Filip, P., Fiorillo, G., Fiorini, M., Francis, K., Galizzi, F., Gallice, N., Garcia-Gamez, D., García-Peris, M. Á., Giammaria, T., Gil-Botella, I., Giugliano, C., Gotti, C., Guarise, M., Guffanti, D., Kovalcuk, M., Lax, I., Lazzaroni, M., Lokajicek, M., Luppi, E., Manthey, S., Martin-Albo, J., Mauri, N., Meazza, L., Minotti, A., Moggi, N., Montagna, E., Montanari, A., Neri, I., Nicolas-Arnaldos, F. J., Palomares, C., Pasqualini, L., Patrizii, L., Pérez-Molina, L., Pessina, G., Pia, V., Poppi, F., Pozzato, M., Querol, M., Rocabado, J., Saadana, A., Sala, P., Sanchez-Castillo, A., Sanchez-Lucas, P., Schifano, F. S., Sirri, G., Smolik, J., Spanu, M., Terranova, F., Tenti, M., Tomassetti, L., Torti, M., Tosi, N., Verdugo de Osa, A., Vieira de Souza, H., Zalesak, J., Zamorano, B., Zani, A., Zucchelli, S., Zuklin, J., and Zutshi, V.

Abstract

The Deep Underground Neutrino Experiment (DUNE) is a next generation experiment aimed to study neutrino oscillation. Its long-baseline configuration will exploit a Near Detector (ND) and a Far Detector (FD) located at a distance of ∼1300 km. The FD will consist of four Liquid Argon Time Projection Chamber (LAr TPC) modules. A Photon Detection System (PDS) will be used to detect the scintillation light produced inside the detector after neutrino interactions. The PDS will be based on light collectors coupled to Silicon Photomultipliers (SiPMs). Different photosensor technologies have been proposed and produced in order to identify the best samples to fullfill the experiment requirements. In this paper, we present the procedure and results of a validation campaign for the Hole Wire Bonding (HWB) MPPCs samples produced by Hamamatsu Photonics K.K. (HPK) for the DUNE experiment, referring to them as `SiPMs'. The protocol for a characterization at cryogenic temperature (77 K) is reported. We present the down-selection criteria and the results obtained during the selection campaign undertaken, along with a study of the main sources of noise of the SiPMs including the investigation of a newly observed phenomenon in this field.

Published
2024

4. Knowledge and Use of Novel Psychoactive Substances in Italy: a Survey-Based Study in the General Population

Author

Zangani, C, Ostinelli, E, Giordano, B, D'Agostino, A, Martinotti, G, Clerici, M, Gambini, O, Schifano, F, Zangani C., Ostinelli E. G., Giordano B., D'Agostino A., Martinotti G., Clerici M., Gambini O., Schifano F., Zangani, C, Ostinelli, E, Giordano, B, D'Agostino, A, Martinotti, G, Clerici, M, Gambini, O, Schifano, F, Zangani C., Ostinelli E. G., Giordano B., D'Agostino A., Martinotti G., Clerici M., Gambini O., and Schifano F.

Abstract

In this study, we aimed to identify the current trend of novel psychoactive substance (NPS) consumption in Italy and the level of knowledge about NPS in the general population and to explore the presence of risk factors for a lifetime NPS misuse. We conducted an anonymous online survey, administered to a large sample of people of any age living in Italy, asking for their knowledge about NPS as well as their history of drug use. Descriptive statistics were reported, and regression analyses were performed to identify risk factors for lifetime use of NPS. A total of 1097 individuals gave a valid response to the survey. A lifetime use of NPS was reported by 13.5%. Multivariate regression analysis showed that male gender (OR 2.33, 95% CI 1.52–3.55), homosexual sexual orientation (OR 2.52, 95% CI 1.21–5.27), a use of emergency services due to alcohol (OR 3.38, 95% CI 2.23–5.12) and previous contact with mental health services (OR 1.58, 95% CI 1.04–2.41) were risk factors for a lifetime use of NPS (p < 0.05). An improvement of preventive strategies and simplified access to information on NPS, especially tailored to individuals at increased risk of misuse, could slow diffusion of NPS and avert the consequences of substance use.

Published
2023

5. QPACE -- a QCD parallel computer based on Cell processors

Author

Baier, H., Boettiger, H., Drochner, M., Eicker, N., Fischer, U., Fodor, Z., Frommer, A., Gomez, C., Goldrian, G., Heybrock, S., Hierl, D., Hüsken, M., Huth, T., Krill, B., Lauritsen, J., Lippert, T., Maurer, T., Mendl, B., Meyer, N., Nobile, A., Ouda, I., Pivanti, M., Pleiter, D., Ries, M., Schäfer, A., Schick, H., Schifano, F., Simma, H., Solbrig, S., Streuer, T., Sulanke, K. -H., Tripiccione, R., Vogt, J. -S., Wettig, T., and Winter, F.

Subjects
High Energy Physics - Lattice, Computer Science - Hardware Architecture
Abstract

QPACE is a novel parallel computer which has been developed to be primarily used for lattice QCD simulations. The compute power is provided by the IBM PowerXCell 8i processor, an enhanced version of the Cell processor that is used in the Playstation 3. The QPACE nodes are interconnected by a custom, application optimized 3-dimensional torus network implemented on an FPGA. To achieve the very high packaging density of 26 TFlops per rack a new water cooling concept has been developed and successfully realized. In this paper we give an overview of the architecture and highlight some important technical details of the system. Furthermore, we provide initial performance results and report on the installation of 8 QPACE racks providing an aggregate peak performance of 200 TFlops., Comment: 21 pages. Poster by T. Maurer and plenary talk by D. Pleiter presented at the "XXVII International Symposium on Lattice Field Theory", July 26-31 2009, Peking University, Beijing, China. Information on recent Green500 ranking added and list of authors extended

Published
2009

7. Status of the QPACE Project

Author

Baier, H., Boettiger, H., Drochner, M., Eicker, N., Fischer, U., Fodor, Z., Goldrian, G., Heybrock, S., Hierl, D., Huth, T., Krill, B., Lauritsen, J., Lippert, T., Maurer, T., McFadden, J., Meyer, N., Nobile, A., Ouda, I., Pivanti, M., Pleiter, D., Schäfer, A., Schick, H., Schifano, F., Simma, H., Solbrig, S., Streuer, T., Sulanke, K. H., Tripiccione, R., Wettig, T., and Winter, F.

Subjects
High Energy Physics - Lattice
Abstract

We give an overview of the QPACE project, which is pursuing the development of a massively parallel, scalable supercomputer for LQCD. The machine is a three-dimensional torus of identical processing nodes, based on the PowerXCell 8i processor. The nodes are connected by an FPGA-based, application-optimized network processor attached to the PowerXCell 8i processor. We present a performance analysis of lattice QCD codes on QPACE and corresponding hardware benchmarks., Comment: 7 pages, poster presented at the XXVI International Symposium on Lattice Field Theory, July 14-19, 2008, Williamsburg, Virginia, USA

Published
2008

8. QCD on the Cell Broadband Engine

Author

Belletti, F., Bilardi, G., Drochner, M., Eicker, N., Fodor, Z., Hierl, D., Kaldass, H., Lippert, T., Maurer, T., Meyer, N., Nobile, A., Pleiter, D., Schaefer, A., Schifano, F., Simma, H., Solbrig, S., Streuer, T., Tripiccione, R., and Wettig, T.

Subjects
High Energy Physics - Lattice
Abstract

We evaluate IBM's Enhanced Cell Broadband Engine (BE) as a possible building block of a new generation of lattice QCD machines. The Enhanced Cell BE will provide full support of double-precision floating-point arithmetics, including IEEE-compliant rounding. We have developed a performance model and applied it to relevant lattice QCD kernels. The performance estimates are supported by micro- and application-benchmarks that have been obtained on currently available Cell BE-based computers, such as IBM QS20 blades and PlayStation 3. The results are encouraging and show that this processor is an interesting option for lattice QCD applications. For a massively parallel machine on the basis of the Cell BE, an application-optimized network needs to be developed., Comment: 7 pages, 3 figures, contribution to Lattice 2007 (Regensburg, Germany)

Published
2007

9. Ianus: an Adpative FPGA Computer

Author

Ianus Collaboration, Belletti, F., Campos, I., Cruz, A., Fernandez, L. A., Jimenez, S., Maiorano, A., Mantovani, F., Marinari, E., Martin-Mayor, V., Navarro, D., Munoz-Sudupe, A., Gaviro, S. Perez, Poli, G., Ruiz-Lorenzo, J. J., Schifano, F., Sciretti, D., Tarancon, A., Tellez, P., Tripiccione, R., and Velasco, J. L.

Subjects
Condensed Matter - Disordered Systems and Neural Networks, Condensed Matter - Other Condensed Matter, Physics - Computational Physics
Abstract

Dedicated machines designed for specific computational algorithms can outperform conventional computers by several orders of magnitude. In this note we describe {\it Ianus}, a new generation FPGA based machine and its basic features: hardware integration and wide reprogrammability. Our goal is to build a machine that can fully exploit the performance potential of new generation FPGA devices. We also plan a software platform which simplifies its programming, in order to extend its intended range of application to a wide class of interesting and computationally demanding problems. The decision to develop a dedicated processor is a complex one, involving careful assessment of its performance lead, during its expected lifetime, over traditional computers, taking into account their performance increase, as predicted by Moore's law. We discuss this point in detail.

Published
2005

10. apeNEXT: A multi-TFlops Computer for Simulations in Lattice Gauge Theory

Author

Bodin, F., Boucaud, Ph., Cabibbo, N., Di Carlo, F., De Pietri, R., Di Renzo, F., Kaldass, H., Lonardo, A., Lukyanov, M., De Luca, S., Micheli, J., Morenas, V., Pene, O., Pleiter, D., Paschedag, N., Rapuano, F., Rossetti, D., Sartori, L., Schifano, F., Simma, H., Tripiccione, R., and Vicini, P.

Subjects
High Energy Physics - Lattice
Abstract

We present the APE (Array Processor Experiment) project for the development of dedicated parallel computers for numerical simulations in lattice gauge theories. While APEmille is a production machine in today's physics simulations at various sites in Europe, a new machine, apeNEXT, is currently being developed to provide multi-Tflops computing performance. Like previous APE machines, the new supercomputer is largely custom designed and specifically optimized for simulations of Lattice QCD., Comment: Poster at the XXIII Physics in Collisions Conference (PIC03), Zeuthen, Germany, June 2003, 3 pages, Latex. PSN FRAP15. Replaced for adding forgotten author

Published
2003

11. The apeNEXT project (Status report)

Author

Bodin, F., Boucaud, Ph., Micheli, J., Pene, O., Cabibbo, N., Di Carlo, F., Lonardo, A., de Luca, S., Rapuano, F., Rossetti, D., Vicini, P., De Pietri, R., Di Renzo, F., Kaldass, H., Paschedag, N., Simma, H., Morenas, V., Pleiter, D., Sartori, L., Schifano, F., and Tripiccione, R.

Subjects
High Energy Physics - Lattice
Abstract

We present the current status of the apeNEXT project. Aim of this project is the development of the next generation of APE machines which will provide multi-teraflop computing power. Like previous machines, apeNEXT is based on a custom designed processor, which is specifically optimized for simulating QCD. We discuss the machine design, report on benchmarks, and give an overview on the status of the software development., Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 8 pages, LaTeX, 12 eps figures. PSN THIT005

Published
2003

12. Status of the apeNEXT project

Author

Ammendola, R., Bodin, F., Boucaud, Ph., Cabibbo, N., Di Carlo, F., De Pietri, R., Di Renzo, F., Errico, W., Fucci, A., Guagnelli, M., Kaldass, H., Lonardo, A., de Luca, S., Micheli, J., Morenas, V., Pene, O., Petronzio, R., Palombi, F., Pleiter, D., Paschedag, N., Rapuano, F., De Riso, P., Rossetti, D., Salamon, A., Salina, G., Sartori, L., Schifano, F., Simma, H., Tripiccione, R., and Vicini, P.

Subjects
High Energy Physics - Lattice
Abstract

We present the current status of the apeNEXT project. Aim of this project is the development of the next generation of APE machines which will provide multi-teraflop computing power. Like previous machines, apeNEXT is based on a custom designed processor, which is specifically optimized for simulating QCD. We discuss the machine design, report on benchmarks, and give an overview on the status of the software development., Comment: 3 pages, Lattice2002(machines). Replaced for adding forgotten author

Published
2002
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13. The APENEXT project

Author

Bodin, F., Boucaud, P., Cabibbo, N., Calvayrac, F., Della Morte, M., De Pietri, R., De Riso, P., Di Carlo, F., Di Renzo, F., Errico, W., Frezzotti, R., Gensch, U., Giorgino, T., Guagnelli, M., Herve, N., Kaldass, H., Lonardo, A., Lukyanov, M., Magazzu, G., Micheli, J., Morenas, V., Mori, L., Palombi, F., Paschedag, N., Pene, O., Petronzio, R., Pleiter, D., Rapuano, F., Rossetti, D., Sartori, L., Simma, H., Schifano, F., Tripiccione, R., and Vicini, P.

Subjects
High Energy Physics - Lattice
Abstract

APENEXT is a new generation APE processor, optimized for LGT simulations. The project follows the basic ideas of previous APE machines and develops simple and cheap parallel systems with multi T-Flops processing power. This paper describes the main features of this new development., Comment: Lattice2001(plenary/machinestatus), 4 pages, 1 eps figure

Published
2001
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14. Status of APEmille

Author

APE-Collaboration, Bartoloni, A., Boucaud, P., Cabibbo, N., Calvayrac, F., Della Morte, M., De Pietri, R., De Riso, P., Di Carlo, F., Di Renzo, F., Errico, W., Frezzotti, R., Giorgino, T., Heitger, J., Lonardo, A., Loukianov, M., Magazzu, G., Micheli, J., Morenas, V., Paschedag, N., Pene, O., Petronzio, R., Pleiter, D., Rapuano, F., Rolf, J., Rossetti, D., Sartori, L., Simma, H., Schifano, F., Torelli, M., Tripiccione, R., Vicini, P., and Wegner, P.

Subjects
High Energy Physics - Lattice
Abstract

This paper presents the status of the APEmille project, which is essentially completed, as far as machine development and construction is concerned. Several large installations of APEmille are in use for physics production runs leading to many new results presented at this conference. This paper briefly summarizes the APEmille architecture, reviews the status of the installations and presents some performance figures for physics codes., Comment: Lattice2001(algorithms), 3 pages, 1 eps figure

Published
2001
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15. Joint versus separate inpatient rehabilitation treatment for patients with alcohol use disorder or drug use disorder: an observational study

Author

Bender S, Specka M, Buchholz A, Hölscher S, Rist F, Heinz TW, Schifano F, and Scherbaum N

Subjects
alcohol use disorder, drug use disorder, rehabilitation treatment, inpatient treatment, joint treatment, long-term treatment, Public aspects of medicine, RA1-1270
Abstract

Stefan Bender,1 Michael Specka,2 Angela Buchholz,3 Stefan Hölscher,2 Fred Rist,4 Thomas W Heinz,5,6 Fabrizio Schifano,7 Norbert Scherbaum2 1Psychiatry, Psychotherapy and Psychosomatics, LWL-Hospital Marsberg, Marsberg, Germany; 2Department of Addictive Behaviour and Addiction Medicine, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; 3Institute of Medical Psychology; University Hospital Hamburg-Eppendorf, Hamburg, Germany; 4Insitute for Psychology, University of Münster, Münster, Germany; 5Psychiatry, Psychotherapy and Psychosomatics, LWL-Hospital Warstein, Warstein, Germany; 6Addiction Hospital St. Vitus, Visbek, Germany; 7Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Hertfordshire, UK Background: In many national treatment systems, patients with alcohol use disorders (AUD) and those with drug use disorders (DUD) are treated separately, while other systems provide joint treatment for both kinds of substance use disorders (SUDs). Regarding long-term rehabilitation treatment of DUD and AUD patients, there is however a lack of empirical studies on the comparison between a separate versus joint treatment modality. Methods: Data were gathered from 2 rehabilitation units located in small towns from the same German region. One unit provided treatment to a mixed group of AUD and DUD patients, while the other unit treated the 2 groups separately. Staffing, funding, and treatment programs were otherwise similar between facilities. Data were gathered from standardized routine documentation and standardized interviews. In order to understand correlates of premature treatment termination, a logistic regression analysis was performed, with treatment modality and type of SUD as main predictors, and a range of patient characteristics as covariates. Results: Patients (N=319) were diagnosed with AUD (48%), DUD (34%), or AUD plus DUD (18%). Patients in joint treatment showed a higher prevalence of lapses during treatment than those in separate treatment (26% versus 12%; p=0.009), but there was no significant difference in the prevalence of premature terminations (38% versus 44%, p=0.26). Treatment modality and interaction between modality and type of SUD was not significantly associated with premature termination. Joint treatment completers showed higher satisfaction with treatment than separate treatment completers (p

Published
2018

16. Increased violence and aggression levels during the SARS-Cov-2 pandemic; data from three London acute psychiatric inpatient facilities.

Author

Bonaccorso, S., primary, Ajnakina, O., additional, Ricciardi, A., additional, Ouabbou, S., additional, Wilson, J., additional, Theleritis, C., additional, Badhan, M., additional, Metastasio, A., additional, Stewart, N., additional, Barczyck, M., additional, Johansson, F., additional, Tharmaraja, T., additional, and Schifano, F., additional

Published
2023
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17. QPACE: power-efficient parallel architecture based on IBM PowerXCell 8i

Author

Baier, H., Boettiger, H., Drochner, M., Eicker, N., Fischer, U., Fodor, Z., Frommer, A., Gomez, C., Goldrian, G., Heybrock, S., Hierl, D., Hüsken, M., Huth, T., Krill, B., Lauritsen, J., Lippert, T., Maurer, T., Mendl, B., Meyer, N., Nobile, A., Ouda, I., Pivanti, M., Pleiter, D., Ries, M., Schäfer, A., Schick, H., Schifano, F., Simma, H., Solbrig, S., Streuer, T., Sulanke, K.-H., Tripiccione, R., Vogt, J.-S., Wettig, T., and Winter, F.

Abstract

Abstract: QPACE is a novel massively parallel architecture optimized for lattice QCD simulations. Each node comprises an IBM PowerXCell 8i processor. The nodes are interconnected by a custom 3-dimensional torus network implemented on an FPGA. The architecture was systematically optimized with respect to power consumption. This put QPACE in the number one spot on the Green500 List published in November 2009. In this paper we give an overview of the architecture and highlight the steps taken to improve power efficiency.

Published
2024
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20. A systematic review of the nature of dispensing errors in hospital pharmacies

Author

Aldhwaihi K, Schifano F, Pezzolesi C, and Umaru N

Subjects
Dispensing errors, Medication errors, Hospital pharmacy, Patient safety, Contributed factors., Pharmacy and materia medica, RS1-441
Abstract

Khaled Aldhwaihi, Fabrizio Schifano, Cinzia Pezzolesi, Nkiruka Umaru Department of Pharmacy, University of Hertfordshire, Hatfield, UK Background: Dispensing errors are common in hospital pharmacies. Investigating dispensing errors is important for identifying the factors involved and developing strategies to reduce their occurrence. Objectives: To review published studies exploring the incidence and types of dispensing errors in hospital pharmacies and factors contributing to these errors. Methods: Electronic databases including PubMed, Scopus, Ovid, and Web of Science were searched for articles published between January 2000 and January 2015. Inclusion criteria were: studies published in English, and studies investigating type, incidence and factors contributing to dispensing errors in hospital pharmacies. One researcher searched for all relevant published articles, screened all titles and abstracts, and obtained complete articles. A second researcher assessed the titles, abstracts, and complete articles to verify the reliability of the selected articles. Key findings: Fifteen studies met the inclusion criteria all of which were conducted in just four countries. Reviewing incident reports and direct observation were the main methods used to investigate dispensing errors. Dispensing error rates varied between countries (0.015%–33.5%) depending on the dispensing system, research method, and classification of dispensing error types. The most frequent dispensing errors reported were dispensing the wrong medicine, dispensing the wrong drug strength, and dispensing the wrong dosage form. The most common factors associated with dispensing errors were: high workload, low staffing, mix-up of look-alike/sound-alike drugs, lack of knowledge/experience, distractions/interruptions, and communication problems within the dispensary team. Conclusion: Studies relating to dispensing errors in hospital pharmacies are few in number and have been conducted in just four countries. The majority of these studies focused on the investigation of dispensing error types with no mention of contributing factors or strategies for reducing dispensing errors. Others studies are thus needed to investigate dispensing errors in hospital pharmacies, and a combined approach is recommended to investigate contributing factors associated with dispensing errors and explore strategies for reducing these errors. Keywords: dispensing errors, medication errors, hospital pharmacy, patient safety, contributing factors

Published
2016

21. Coded masks for imaging of neutrino events

Author

Andreotti, M, Bernardini, P, Bersani, A, Bertolucci, S, Biagi, S, Branca, A, Brizzolari, C, Brunetti, G, Cagnoli, I, Calabrese, R, Caminata, A, Campani, A, Carniti, P, Cataldo, R, Cattadori, C, Cherubini, S, Cicero, V, Citterio, M, Copello, S, Cova, P, Cristaldo Morales, E, Davini, S, Delmonte, N, De Matteis, G, Domizio, S, Noto, L, Distefano, C, Giammaria, T, Guarise, M, Falcone, A, Ferraro, F, Fiorini, M, Gallice, N, Gotti, C, Guerzoni, M, Iliescu, M, Ingratta, G, Lazzaroni, M, Lax, I, Laurenti, G, Leaci, A, Luppi, E, Martina, L, Mauri, N, Minotti, A, Moggi, N, Montagna, E, Montanari, A, Montanino, D, Pallavicini, M, Panareo, M, Parozzi, E, Pasqualini, L, Patrizii, L, Pessina, G, Poppi, F, Pozzato, M, Pia, V, Riboldi, S, Riccobene, G, Sala, P, Sapienza, P, Schifano, F, Sirri, G, Spanu, M, Stanco, L, Surdo, A, Taibi, A, Tenti, M, Terranova, F, Testera, G, Tomassetti, L, Torti, M, Tosi, N, Travaglini, R, Uboldi, L, Vicenzi, M, Zani, A, Zucchelli, S, Andreotti M., Bernardini P., Bersani A., Bertolucci S., Biagi S., Branca A., Brizzolari C., Brunetti G., Cagnoli I., Calabrese R., Caminata A., Campani A., Carniti P., Cataldo R., Cattadori C., Cherubini S., Cicero V., Citterio M., Copello S., Cova P., Cristaldo Morales E., Davini S., Delmonte N., De Matteis G., Domizio S. D., Noto L. D., Distefano C., Giammaria T., Guarise M., Falcone A., Ferraro F., Fiorini M., Gallice N., Gotti C., Guerzoni M., Iliescu M. A., Ingratta G., Lazzaroni M., Lax I., Laurenti G., Leaci A., Luppi E., Martina L., Mauri N., Minotti A., Moggi N., Montagna E., Montanari A., Montanino D., Pallavicini M., Panareo M., Parozzi E. G., Pasqualini L., Patrizii L., Pessina G., Poppi F., Pozzato M., Pia V., Riboldi S., Riccobene G., Sala P., Sapienza P., Schifano F., Sirri G., Spanu M., Stanco L., Surdo A., Taibi A., Tenti M., Terranova F., Testera G., Tomassetti L., Torti M., Tosi N., Travaglini R., Uboldi L., Vicenzi M., Zani A., Zucchelli S., Andreotti, M, Bernardini, P, Bersani, A, Bertolucci, S, Biagi, S, Branca, A, Brizzolari, C, Brunetti, G, Cagnoli, I, Calabrese, R, Caminata, A, Campani, A, Carniti, P, Cataldo, R, Cattadori, C, Cherubini, S, Cicero, V, Citterio, M, Copello, S, Cova, P, Cristaldo Morales, E, Davini, S, Delmonte, N, De Matteis, G, Domizio, S, Noto, L, Distefano, C, Giammaria, T, Guarise, M, Falcone, A, Ferraro, F, Fiorini, M, Gallice, N, Gotti, C, Guerzoni, M, Iliescu, M, Ingratta, G, Lazzaroni, M, Lax, I, Laurenti, G, Leaci, A, Luppi, E, Martina, L, Mauri, N, Minotti, A, Moggi, N, Montagna, E, Montanari, A, Montanino, D, Pallavicini, M, Panareo, M, Parozzi, E, Pasqualini, L, Patrizii, L, Pessina, G, Poppi, F, Pozzato, M, Pia, V, Riboldi, S, Riccobene, G, Sala, P, Sapienza, P, Schifano, F, Sirri, G, Spanu, M, Stanco, L, Surdo, A, Taibi, A, Tenti, M, Terranova, F, Testera, G, Tomassetti, L, Torti, M, Tosi, N, Travaglini, R, Uboldi, L, Vicenzi, M, Zani, A, Zucchelli, S, Andreotti M., Bernardini P., Bersani A., Bertolucci S., Biagi S., Branca A., Brizzolari C., Brunetti G., Cagnoli I., Calabrese R., Caminata A., Campani A., Carniti P., Cataldo R., Cattadori C., Cherubini S., Cicero V., Citterio M., Copello S., Cova P., Cristaldo Morales E., Davini S., Delmonte N., De Matteis G., Domizio S. D., Noto L. D., Distefano C., Giammaria T., Guarise M., Falcone A., Ferraro F., Fiorini M., Gallice N., Gotti C., Guerzoni M., Iliescu M. A., Ingratta G., Lazzaroni M., Lax I., Laurenti G., Leaci A., Luppi E., Martina L., Mauri N., Minotti A., Moggi N., Montagna E., Montanari A., Montanino D., Pallavicini M., Panareo M., Parozzi E. G., Pasqualini L., Patrizii L., Pessina G., Poppi F., Pozzato M., Pia V., Riboldi S., Riccobene G., Sala P., Sapienza P., Schifano F., Sirri G., Spanu M., Stanco L., Surdo A., Taibi A., Tenti M., Terranova F., Testera G., Tomassetti L., Torti M., Tosi N., Travaglini R., Uboldi L., Vicenzi M., Zani A., and Zucchelli S.

Abstract

The capture of scintillation light emitted by liquid Argon and Xenon under molecular excitations by charged particles is still a challenging task. Here we present a first attempt to design a device able to have a sufficiently high photon detection efficiency, in order to reconstruct the path of ionizing particles. The study is based on the use of masks to encode the light signal combined with single-photon detectors, showing the capability to detect tracks over focal distances of about tens of centimeters. From numerical simulations it emerges that it is possible to successfully decode and recognize signals, even of rather complex topology, with a relatively limited number of acquisition channels. Thus, the main aim is to elucidate a proof of principle of a technology developed in very different contexts, but which has potential applications in liquid argon detectors that require a fast reading. The findings support us to think that such innovative technique could be very fruitful in a new generation of detectors devoted to neutrino physics.

Published
2021

22. A systematic review of counterfeit and substandard medicines in field quality surveys

Author

Alghannam AFA, Aslanpour Z, Evans S, and Schifano F

Subjects
Counterfeit, Substandard, Poor quality, SSFFC, medicine and drug, Pharmacy and materia medica, RS1-441
Abstract

Abdulaziz Fahad Abdulaziz Alghannam, Zoe Aslanpour, Sara Evans, Fabrizio Schifano Department of Pharmacy, University of Hertfordshire, Hatfield, Hertfordshire, United Kingdom Objectives: Counterfeit and substandard medicines pose a great threat to public health and the economy worldwide. Reports suggest their prevalence is increasing and can no longer be ignored. A detailed account on the current nature of the problem and identification of knowledge limitations in terms of geographical location, medicine classes, and type of medicine analysis performed is not available. Our objective was to systematically review articles that have reported investigations of counterfeit and substandard medicines. Design: Systematic review. Data sources: PubMed, Scopus, and ISI Web of Knowledge. Data Selection: Prospective field quality surveys on counterfeit and substandard medicines were selected from all available records within the selected databases up to December 31, 2013. All prospective studies performing chemical analysis on medicine samples were identified using the key search terms “counterfeit” or “substandard” and “medicine” or “drug” or “pharmaceutical.” The title, abstract, and/or full articles were reviewed for relevance according to a predetermined set of inclusion and exclusion criteria. Medicines procured from the Internet are beyond the scope of this review. Results: Sixty-six research articles were found that fulfilled our inclusion criteria. The majority of medicine quality surveys were conducted in specific areas of Africa and Asia. Within these two continents, medicine quality reports covering the Northern part of Africa and the Western part of Asia in the Middle East are extremely scarce. Other continents such as North or South America and Europe were covered in limited articles, whereas the Australian continent had no reports. Moreover, most studies examined medicines that treat infectious diseases; very few articles addressed popular medicines for chronic diseases or clinically significant narrow therapeutic index medicines or cancer treatments, despite media reports of quality problems in these medicines. Furthermore, only six (9%) research articles attempted all levels of medicine quality analysis available through laboratory analysis, authentication of source, and package inspection to comprehensively identify the nature of the problem and so conclude whether the medicines were counterfeit or substandard. Conclusion: Substandard and counterfeit medicines should be considered and identified through means of chemical analysis, physical analysis, authentication of source, and package inspection in any field medicine quality survey. More research is encouraged to examine the medicine quality in neglected parts of the globe and on neglected, yet popular and clinically significant, noncommunicable disease medicines. Keywords: counterfeit, substandard, poor quality, SSFFC, medicine and drug

Published
2014

27. Is finasteride intake associated with penile curvature/peyronie’s disease? Assessment of both the food and drug administration (FDA) and the European Medicines Agency (EMA) pharmacovigilance databases

Author

Schifano, N., primary, Capogrosso, P., additional, Boeri, L., additional, Pozzi, E.P., additional, Belladelli, F., additional, Chiappini, S., additional, Castiglione, F., additional, Deho’, F., additional, Montorsi, F., additional, Salonia, A., additional, and Schifano, F., additional

Published
2021
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29. Drugs associated the most with retroperitoneal fibrosis: Assessment of the 2015-2020 Food and Drug Administration (FDA) pharmacovigilance database

Author

Schifano, N., primary, Capogrosso, P., additional, Boeri, L., additional, Pozzi, E.P., additional, Belladelli, F., additional, Chiappini, S., additional, Cakir, O.O., additional, Rewhorn, M., additional, Castiglione, F., additional, Alnajjar, H.M., additional, Muneer, A., additional, Deho’, F., additional, Schifano, F., additional, Montorsi, F., additional, and Salonia, A., additional

Published
2021
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31. QPACE: power-efficient parallel architecture based on IBM PowerXCell 8i

Author

Baier, H., Boettiger, H., Drochner, M., Eicker, N., Fischer, U., Fodor, Z., Frommer, A., Gomez, C., Goldrian, G., Heybrock, S., Hierl, D., Hüsken, M., Huth, T., Krill, B., Lauritsen, J., Lippert, T., Maurer, T., Mendl, B., Meyer, N., Nobile, A., Ouda, I., Pivanti, M., Pleiter, D., Ries, M., Schäfer, A., Schick, H., Schifano, F., Simma, H., Solbrig, S., Streuer, T., Sulanke, K.-H., Tripiccione, R., Vogt, J.-S., Wettig, T., and Winter, F.

Published
2010
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33. Patterns of management of patients with dual disorder (Psychosis) in Italy: A survey of psychiatrists and other physicians focusing on clinical practice

Author

Clerici, M, de Bartolomeis, A, De Filippis, S, Ducci, G, Maremmani, I, Martinotti, G, Schifano, F, Clerici M., de Bartolomeis A., De Filippis S., Ducci G., Maremmani I., Martinotti G., Schifano F., Clerici, M, de Bartolomeis, A, De Filippis, S, Ducci, G, Maremmani, I, Martinotti, G, Schifano, F, Clerici M., de Bartolomeis A., De Filippis S., Ducci G., Maremmani I., Martinotti G., and Schifano F.

Abstract

Patients with severe psychotic disorders such as schizophrenia, schizoaffective, and bipolar disorders frequently suffer from concomitant substance use disorders (SUDs)–Dual Disorder (DD) patients. In order to better understand current practices for management of patients with psychotic episodes and concomitant SUD in Italy, we carried out a survey of psychiatrists on current routine practice among prescribers. These aspects can help to identify at-risk patients, improve current prescribing practices, and favor early intervention. An ad hoc survey of 17 questions was administered to psychiatrists via electronic polling and on-line distribution; 448 completed questionnaires were collected. Comorbid substance abuse was most frequently diagnosed within the context of anxiety disorder (46%), followed by bipolar disorder (25%), and schizophrenia/schizoaffective disorder (12%). The vast majority of respondents felt that patient management was becoming more complex due to substance abuse. The areas reported to be most affected in patients with SUD were functioning, interpersonal relations, and impulsivity, while sensory perception disorders, ideation, agitation, and impulsivity were the most frequently reported symptoms. In the acute setting, haloperidol was used as the first-line agent of choice followed by aripiprazole and olanzapine. In the maintenance phase, aripiprazole was the dominantly used first-line agent, followed by olanzapine. Almost half of respondents used long-acting agents, while about one-third did not. Among those prescribing long-acting agents, efficacy, control of impulsivity, and control of specific symptoms were cited as motivators, while in the maintenance phase, better adherence, and tolerability were mainly cited. From the responses to the present survey, it is clear that the respondents are aware of the problem of SUD in psychotic patients. While treatment be optimized in terms of the choice and formulation of antipsychotics, greater emphasis sho

Published
2018

34. On-line tracking processors at hadron colliders: The SVT experience at CDF II and beyond

Author

Adelman, J., Annovi, A., Aoki, M., Bellinger, J., Berry, E., Bitossi, M., Bogdan, M., Carosi, R., Catastini, P., Cerri, A., Chappa, S., Crescioli, F., Dell Orso, M., Di Ruzza, B., Donati, S., Furic, I., Giannetti, P., Ginsburg, C.M., Liu, T., Maruyama, T., Palla, F., Pedron, I., Piendibene, M., Pitkanen, M., Punzi, G., Reisert, B., Rescigno, M., Ristori, L., Sanders, H., Sartori, L., Schifano, F., Sforza, F., Shochet, M., Spinella, F., Tang, F., Torre, S., Tripiccione, R., Volpi, G., Yang, U.K., and Zanetti, A.M.

Published
2007
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35. A VLSI processor for fast track finding based on content addressable memories

Author

Annovi, A., Bardi, A., Bitossi, M., Chiozzi, S., Damiani, C., Dell'Orso, M., Giannetti, P., Giovacchini, P., Marchiori, G., Pedron, I., Piendibene, M., Sartori, L., Schifano, F., Spinella, F., Torre, S., and Tripiccione, R.

Subjects
Particle tracks (Nuclear physics) -- Measurement, Object recognition (Computers) -- Analysis, Pattern recognition -- Analysis, Very-large-scale integration -- Research, Parallel processing -- Research, Parallel processing, Business, Electronics, Electronics and electrical industries
Abstract

The authors describe a VLSI processor for pattern recognition based on content addressable memory (CAM) architecture, optimized for on-line track finding in high-energy physics experiments. A large CAM bank stores all trajectories of interest and extracts the ones compatible with a given event. This task is naturally parallelized by a CAM architecture able to output identified trajectories, searching for matches on 96-bit wide patterns, in just a few 40-MHz clock cycles. We have developed this device (called the AMchip03 processor) for the silicon vertex trigger (SVT) upgrade at the Collider Detector experiment at Fermilab (CDF) using a standard-cell VLSI design methodology. This approach provides excellent pattern density, while sparing many of the complexities and risks associated to a full-custom design. The cost/performance ratio is better by well more than one order of magnitude than an FPGA-based design. This processor has a flexible and easily configurable structure that makes it suitable for applications in other experimental environments. They look forward to sharing this technology. Index Terms--Parallel processing, particle tracking, pattern matching, triggering, very large scale integration (VLSI).

Published
2006

43. The apeNEXT project

Author

Bodin, F., Boucaud, Ph., Cabibbo, N., Di Carlo, F., De Pietri, R., Di Renzo, F., Errico, W., Kaldass, H., Lonardo, A., de Luca, S., Micheli, J., Morenas, V., Pene, O., Pleiter, D., Paschedag, N., Rapuano, F., Rossetti, D., Sartori, L., Schifano, F., Simma, H., Tripiccione, R., and Vicini, P.

Published
2005
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44. apeNEXT: A Multi-TFlops computer for elementary particle physics

Author

Bodin, F., primary, Boucaud, Ph., additional, Cabibbo, N., additional, Di Carlo, F., additional, De Pietri, R., additional, Di Renzo, F., additional, Kaldass, H., additional, Lonardo, A., additional, Lukyanov, M., additional, de Luca, S., additional, Micheli, J., additional, Morenas, V., additional, Paschedag, N., additional, Pene, O., additional, Pleiter, D., additional, Rapuano, F., additional, Sartori, L., additional, Schifano, F., additional, Simma, H., additional, Tripiccione, R., additional, and Vicini, P., additional

Published
2004
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47. Dorsolateral Prefrontal Cortex Impairment in Methoxetamine-Induced Psychosis: An 18F-FDG PET/CT Case Study.

Author

Moccia, L, Tofani, A, Mazza, M, Covino, M, Martinotti, G, Schifano, F, Janiri, L, Di Nicola, M., Moccia L, Mazza M, Covino M (ORCID:0000-0002-6709-2531), Martinotti G, Janiri L (ORCID:0000-0002-1633-9418), Di Nicola M. (ORCID:0000-0001-7457-0426), Moccia, L, Tofani, A, Mazza, M, Covino, M, Martinotti, G, Schifano, F, Janiri, L, Di Nicola, M., Moccia L, Mazza M, Covino M (ORCID:0000-0002-6709-2531), Martinotti G, Janiri L (ORCID:0000-0002-1633-9418), and Di Nicola M. (ORCID:0000-0001-7457-0426)

Abstract

Novel psychoactive substances (NPSs) have currently become a major public health concern because of relatively easy accessibility to these compounds and difficulty in identifying them with routine laboratory techniques. Here, we report the 18F-fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) case study of a 23-year-old man who developed a substance-induced psychotic disorder after having intravenously injected himself with an unspecified amount of methoxetamine (MXE), a ketamine derivative hallucinogen. From a clinical perspective, a blunted affective responsiveness with diminished social drive and sense of purpose, along with a profound detachment from the environment, was observed. Psychometric and neuropsychological assessments highlighted severe dissociative symptoms and lack of motivation, along with a mild impairment of verbal fluency, working memory, and attention. Patient's 18F-FDG PET/CT scans displayed a significant bilateral deficit of tracer uptake within the dorsolateral prefrontal cortex (DLPFC). DLPFC activity is critical to goal-oriented cognitive functions, including working memory and sustained attention. DLPFC is also involved in both the temporal integration across multiple sensory modes and in the volitional control of actions, leading to the possibility to construct logically coherent temporal configurations of thought, speech, and behavior. This report highlights that a single acute MXE intoxication may produce severe brain impairment

Published
2019

49. Synthetic cannabinoid use in a case series of patients with psychosis presenting to acute psychiatric settings: Clinical presentation and management issues

Author

Bonaccorso, S. Metastasio, A. Ricciardi, A. Stewart, N. Jamal, L. Rujully, N.-U.-D. Theleritis, C. Ferracuti, S. Ducci, G. Schifano, F.

Abstract

Background: Novel Psychoactive Substances (NPS) are a heterogeneous class of synthetic molecules including synthetic cannabinoid receptor agonists (SCRAs). Psychosis is associated with SCRAs use. There is limited knowledge regarding the structured assessment and psychometric evaluation of clinical presentations, analytical toxicology and clinical management plans of patients presenting with psychosis and SCRAs misuse. Methods: We gathered information regarding the clinical presentations, toxicology and care plans of patients with psychosis and SCRAs misuse admitted to inpatients services. Clinical presentations were assessed using the PANSS scale. Vital signs data were collected using the National Early Warning Signs tool. Analytic chemistry data were collected using urine drug screening tests for traditional psychoactive substances and NPS. Results: We described the clinical presentation and management plan of four patients with psychosis and misuse of SCRAs. Conclusion: The formulation of an informed clinical management plan requires a structured assessment, identification of the index NPS, pharmacological interventions, increases in nursing observations, changes to leave status and monitoring of the vital signs. The objective from using these interventions is to maintain stable physical health whilst rapidly improving the altered mental state. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Published
2018

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