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3. Intraoperative Computed Tomography

Author

Tonn, J. C., Schichor, C., Schnell, O., Zausinger, S., Uhl, E., Morhard, D., Reiser, M., Pamir, M. Necmettin, editor, Seifert, Volker, editor, and Kiris, Talat, editor

Published
2011
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5. Perifocal edema in meningioma patients is correlated with impaired whole brain connectivity as detected by resting-state functional MRI

Author

Stöcklein, V, Wunderlich, S, Papazov, B, Schmutzer, M, Schichor, C, Thon, N, Liu, H, Tonn, JC, and Stöcklein, S

Subjects
ddc: 610, Medicine and health
Abstract

Objective: Resting-state functional MRI (rsfMRI) can be used to assess whole brain functional connectivity and has been shown to serve as a marker for disease severity in glioma patients. However, it is unclear whether extraaxial tumors such as intracranial meningeomas might lead to comparable effects. [for full text, please go to the a.m. URL]

Published
2022
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7. Molecular and translational advances in meningiomas

Author

Suppiah S., Nassiri F., Bi W. L., Dunn I. F., Hanemann C. O., Horbinski C. M., Hashizume R., James C. D., Mawrin C., Noushmehr H., Perry A., Sahm F., Sloan A., Von Deimling A., Wen P. Y., Aldape K., Zadeh G., Au K., Barnhartz-Sloan J., Brastianos P. K., Butowski N., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Galanis E., Giannini C., Goldbrunner R., Griffith B., Herold-Mende C., Huang R. Y., James D., Jenkinson M. D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mansouri A., McDermott M., Munoz D., Ng H. -K., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N. O., Selman W., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J. C., Tsang D., Vogelbaum M. A., Deimling A. V., Walbert T., Westphal M., Workewych A. M., Suppiah S., Nassiri F., Bi W.L., Dunn I.F., Hanemann C.O., Horbinski C.M., Hashizume R., James C.D., Mawrin C., Noushmehr H., Perry A., Sahm F., Sloan A., Von Deimling A., Wen P.Y., Aldape K., Zadeh G., Au K., Barnhartz-Sloan J., Brastianos P.K., Butowski N., Carlotti C., Cusimano M.D., Dimeco F., Drummond K., Galanis E., Giannini C., Goldbrunner R., Griffith B., Herold-Mende C., Huang R.Y., James D., Jenkinson M.D., Jungk C., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Mamatjan Y., Mansouri A., McDermott M., Munoz D., Ng H.-K., Pirouzmand F., Poisson L.M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N.O., Selman W., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J.C., Tsang D., Vogelbaum M.A., Deimling A.V., Walbert T., Westphal M., and Workewych A.M.

Subjects
Cancer Research, Supplement Articles, Genomics, Intracranial Neoplasm, sporadic meningioma, Bioinformatics, World health, Translational Research, Biomedical, Meningioma, 03 medical and health sciences, biomolecular, 0302 clinical medicine, Meningeal Neoplasms, otorhinolaryngologic diseases, medicine, Recurrent disease, Humans, Meningeal Neoplasm, Molecular Targeted Therapy, xenograft, Stage (cooking), neoplasms, MENINGIOMA, business.industry, cell line, Prognosis, medicine.disease, Combined Modality Therapy, nervous system diseases, 3. Good health, Clinical trial, Oncology, 030220 oncology & carcinogenesis, Neurology (clinical), genetic, business, epigenetic, 030217 neurology & neurosurgery
Abstract

Meningiomas are the most common primary intracranial neoplasm. The current World Health Organization (WHO) classification categorizes meningiomas based on histopathological features, but emerging molecular data demonstrate the importance of genomic and epigenomic factors in the clinical behavior of these tumors. Treatment options for symptomatic meningiomas are limited to surgical resection where possible and adjuvant radiation therapy for tumors with concerning histopathological features or recurrent disease. At present, alternative adjuvant treatment options are not available in part due to limited historical biological analysis and clinical trial investigation on meningiomas. With advances in molecular and genomic techniques in the last decade, we have witnessed a surge of interest in understanding the genomic and epigenomic landscape of meningiomas. The field is now at the stage to adopt this molecular knowledge to refine meningioma classification and introduce molecular algorithms that can guide prediction and therapeutics for this tumor type. Animal models that recapitulate meningiomas faithfully are in critical need to test new therapeutics to facilitate rapid-cycle translation to clinical trials. Here we review the most up-to-date knowledge of molecular alterations that provide insight into meningioma behavior and are ready for application to clinical trial investigation, and highlight the landscape of available preclinical models in meningiomas.

Published
2019

8. Life after surgical resection of a meningioma: a prospective cross-sectional study evaluating health-related quality of life

Author

Nassiri F., Price B., Shehab A., Au K., Cusimano M. D., Jenkinson M. D., Jungk C., Mansouri A., Santarius T., Suppiah S., Teng K. X., Toor G. S., Zadeh G., Walbert T., Drummond K. J., Aldape K., Barnhartz-Sloan J., Bi W. L., Brastianos P. K., Butowski N., Carlotti C., Dimeco F., Dunn I. F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C. O., Herold-Mende C., Horbinski C., Huang R. Y., James D., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mawrin C., McDermott M., Munoz D., Noushmehr H., Ng H. -K., Perry A., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Sahm F., Saladino A., Schichor C., Schultz D., Schmidt N. O., Selman W., Sloan A., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J. C., Tsang D., Vogelbaum M. A., Deimling A. V., Wen P. Y., Westphal M., Workewych A. M., Nassiri F., Price B., Shehab A., Au K., Cusimano M.D., Jenkinson M.D., Jungk C., Mansouri A., Santarius T., Suppiah S., Teng K.X., Toor G.S., Zadeh G., Walbert T., Drummond K.J., Aldape K., Barnhartz-Sloan J., Bi W.L., Brastianos P.K., Butowski N., Carlotti C., Dimeco F., Dunn I.F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C.O., Herold-Mende C., Horbinski C., Huang R.Y., James D., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Mamatjan Y., Mawrin C., McDermott M., Munoz D., Noushmehr H., Ng H.-K., Perry A., Pirouzmand F., Poisson L.M., Pollo B., Raleigh D., Sahm F., Saladino A., Schichor C., Schultz D., Schmidt N.O., Selman W., Sloan A., Spears J., Snyder J., Tabatabai G., Tatagiba M., Tirapelli D., Tonn J.C., Tsang D., Vogelbaum M.A., Deimling A.V., Wen P.Y., Westphal M., and Workewych A.M.

Subjects
Male, cognition, Cancer Research, medicine.medical_specialty, Cross-sectional study, insomnia, Population, Neurosurgery, Supplement Articles, meningioma, surgery, Meningioma, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Surveys and Questionnaires, Internal medicine, Meningeal Neoplasms, otorhinolaryngologic diseases, medicine, Humans, Longitudinal Studies, Prospective Studies, Prospective cohort study, education, education.field_of_study, business.industry, COGNIÇÃO, Cognition, Middle Aged, Prognosis, medicine.disease, humanities, 3. Good health, health-related quality of life, Cross-Sectional Studies, Oncology, 030220 oncology & carcinogenesis, Quality of Life, Female, fatigue, Neurology (clinical), business, 030217 neurology & neurosurgery, Follow-Up Studies, Cohort study
Abstract

Background Few studies have evaluated the health-related quality of life (HRQoL) of patients with meningiomas. Here, we report the largest prospective, longitudinal cross-sectional cohort study of HRQoL in meningiomas to date, in order to identify possible actionable determinants of global HRQoL. Methods Adults who had undergone resection of a grade I intracranial meningioma and were in routine follow-up at a single large tertiary center underwent HRQoL assessment using the QLQ-C30 questionnaire administered opportunistically at follow-up visits. Averaged transformed QLQ-C30 scores at 12-month intervals were compared with scores from a normative reference population, with reference to known minimal clinically meaningful difference (CMD) in scores. To evaluate for possible determinants of changes in global HRQoL, global HRQoL scores were correlated (Spearman's Rho) with subdomain and symptom scores and with interval time from surgical resection. Results A total of 291 postoperative patients with histologically confirmed and surgically treated grade I meningiomas consented to participation and a total of 455 questionnaires were included for analysis. Patients with meningiomas reported reduced global HRQoL at nearly every 12-month interval with clinically and statistically significant impairments at 12, 48, 108, and 120 months postoperative compared with the normative population (P < 0.05). Meningioma patients at the 12-month interval also reported a reduction of each subdomain of HRQoL assessment (P < 0.05); however, a CMD was only seen in cognitive functioning. Physical, emotional, cognitive, and social subdomains, as well as fatigue and sleep/insomnia, were significantly associated with global HRQoL at the first 12-month interval. Overall, there was no significant correlation between time from surgery and global HRQoL or the subdomain functional or symptom sections of the QLQ-C30. Conclusions Meningioma patients report considerable limitations in HRQoL for more than 120 months after surgery, particularly in cognitive, emotional, and social function, as well as suffering significant fatigue and sleep impairment compared with a normative reference population. The majority of these reported functional impairments and symptoms are strongly associated with global HRQoL and thus can be considered determinants of global HRQoL that if treated, have the potential to improve HRQoL for our meningioma patients. This hypothesis requires future study of targeted interventions to determine their efficacy.

Published
2019

9. Surgical resection of cavernous angioma located within eloquent brain areas: International survey of the practical management among 19 specialized centers

Author

Zanello, M, Meyer, B, Still, M, Goodden, J, Colle, H, Schichor, C, Bello, L, Wager, M, Smits, A, Rydenhag, B, Tate, M, Metellus, P, Hamer, P, Spena, G, Capelle, L, Mandonnet, E, Robles, S, Sarubbo, S, Martino Gonzalez, J, Fontaine, D, Reyns, N, Krieg, S, Huberfeld, G, Wostrack, M, Colle, D, Robert, E, Noens, B, Muller, P, Yusupov, N, Rossi, M, Conti Nibali, M, Papagno, C, Visser, V, Baaijen, H, Galbarritu, L, Chioffi, F, Bucheli, C, Roux, A, Dezamis, E, Duffau, H, Pallud, J, Zanello M., Meyer B., Still M., Goodden J. R., Colle H., Schichor C., Bello L., Wager M., Smits A., Rydenhag B., Tate M., Metellus P., Hamer P. D. W., Spena G., Capelle L., Mandonnet E., Robles S. G., Sarubbo S., Martino Gonzalez J., Fontaine D., Reyns N., Krieg S. M., Huberfeld G., Wostrack M., Colle D., Robert E., Noens B., Muller P., Yusupov N., Rossi M., Conti Nibali M., Papagno C., Visser V., Baaijen H., Galbarritu L., Chioffi F., Bucheli C., Roux A., Dezamis E., Duffau H., Pallud J., Zanello, M, Meyer, B, Still, M, Goodden, J, Colle, H, Schichor, C, Bello, L, Wager, M, Smits, A, Rydenhag, B, Tate, M, Metellus, P, Hamer, P, Spena, G, Capelle, L, Mandonnet, E, Robles, S, Sarubbo, S, Martino Gonzalez, J, Fontaine, D, Reyns, N, Krieg, S, Huberfeld, G, Wostrack, M, Colle, D, Robert, E, Noens, B, Muller, P, Yusupov, N, Rossi, M, Conti Nibali, M, Papagno, C, Visser, V, Baaijen, H, Galbarritu, L, Chioffi, F, Bucheli, C, Roux, A, Dezamis, E, Duffau, H, Pallud, J, Zanello M., Meyer B., Still M., Goodden J. R., Colle H., Schichor C., Bello L., Wager M., Smits A., Rydenhag B., Tate M., Metellus P., Hamer P. D. W., Spena G., Capelle L., Mandonnet E., Robles S. G., Sarubbo S., Martino Gonzalez J., Fontaine D., Reyns N., Krieg S. M., Huberfeld G., Wostrack M., Colle D., Robert E., Noens B., Muller P., Yusupov N., Rossi M., Conti Nibali M., Papagno C., Visser V., Baaijen H., Galbarritu L., Chioffi F., Bucheli C., Roux A., Dezamis E., Duffau H., and Pallud J.

Abstract

Purpose: The practical management of cavernous angioma located within eloquent brain area before, during and after surgical resection is poorly documented. We assessed the practical pre-operative, intra-operative, and post-operative management of cavernous angioma located within eloquent brain area. Method: An online survey composed of 61 items was sent to 26 centers to establish a multicenter international retrospective cohort of adult patients who underwent a surgical resection as the first-line treatment of a supratentorial cavernous angioma located within or close to eloquent brain area. Results: 272 patients from 19 centers (mean 13.6 ± 16.7 per center) from eight countries were included. The pre-operative management varied significantly between centers and countries regarding the pre-operative functional assessment, the pre-operative epileptological assessment, the first given antiepileptic drug, and the time to surgery. The intra-operative environment varied significantly between centers and countries regarding the use of imaging systems, the use of functional mapping with direct electrostimulations, the extent of resection of the hemosiderin rim, the realization of a post-operative functional assessment, and the time to post-operative functional assessment. The present survey found a post-operative improvement, as compared to pre-operative evaluations, of the functional status, the ability to work, and the seizure control. Conclusions: We observed a variety of practice between centers and countries regarding the management of cavernous angioma located within eloquent regions. Multicentric prospective studies are required to solve relevant questions regarding the management of cavernous angioma-related seizures, the timing of surgery, and the optimal extent of hemosiderin rim resection.

Published
2019

10. Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas

Author

Zanello, M, Goodden, J, Colle, H, Wager, M, Hamer, P, Smits, A, Bello, L, Tate, M, Spena, G, Bresson, D, Capelle, L, Robles, S, Sarubbo, S, Rydenhag, B, Martino, J, Meyer, B, Fontaine, D, Reyns, N, Schichor, C, Metellus, P, Colle, D, Robert, E, Noens, B, Muller, P, Rossi, M, Nibali, M, Papagno, C, Galbarritu, L, De Gopegui, E, Chioffi, F, Bucheli, C, Krieg, S, Wostrack, M, Yusupov, N, Visser, V, Baaijen, J, Roux, A, Dezamis, E, Mandonnet, E, Corns, R, Duffau, H, Pallud, J, Zanello M., Goodden J. R., Colle H., Wager M., Hamer P. C. D. W., Smits A., Bello L., Tate M., Spena G., Bresson D., Capelle L., Robles S. G., Sarubbo S., Rydenhag B., Martino J., Meyer B., Fontaine D., Reyns N., Schichor C., Metellus P., Colle D., Robert E., Noens B., Muller P., Rossi M., Nibali M. C., Papagno C., Galbarritu L., De Gopegui E. R., Chioffi F., Bucheli C., Krieg S. M., Wostrack M., Yusupov N., Visser V., Baaijen J. C., Roux A., Dezamis E., Mandonnet E., Corns R., Duffau H., Pallud J., Zanello, M, Goodden, J, Colle, H, Wager, M, Hamer, P, Smits, A, Bello, L, Tate, M, Spena, G, Bresson, D, Capelle, L, Robles, S, Sarubbo, S, Rydenhag, B, Martino, J, Meyer, B, Fontaine, D, Reyns, N, Schichor, C, Metellus, P, Colle, D, Robert, E, Noens, B, Muller, P, Rossi, M, Nibali, M, Papagno, C, Galbarritu, L, De Gopegui, E, Chioffi, F, Bucheli, C, Krieg, S, Wostrack, M, Yusupov, N, Visser, V, Baaijen, J, Roux, A, Dezamis, E, Mandonnet, E, Corns, R, Duffau, H, Pallud, J, Zanello M., Goodden J. R., Colle H., Wager M., Hamer P. C. D. W., Smits A., Bello L., Tate M., Spena G., Bresson D., Capelle L., Robles S. G., Sarubbo S., Rydenhag B., Martino J., Meyer B., Fontaine D., Reyns N., Schichor C., Metellus P., Colle D., Robert E., Noens B., Muller P., Rossi M., Nibali M. C., Papagno C., Galbarritu L., De Gopegui E. R., Chioffi F., Bucheli C., Krieg S. M., Wostrack M., Yusupov N., Visser V., Baaijen J. C., Roux A., Dezamis E., Mandonnet E., Corns R., Duffau H., and Pallud J.

Abstract

BACKGROUND: The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area. OBJECTIVE: To assess the predictors of preoperative seizure control, postoperative seizure control, and postoperative ability to work, and the safety of the surgery. METHODS: Multicenter international retrospective cohort analysis of adult patients benefitting from a functional-based surgical resection with intraoperative functional brain mapping for a supratentorial CA within or close to eloquent brain areas. RESULTS: A total of 109 patients (66.1% women; mean age 38.4 ± 12.5 yr), were studied. Age >38 yr (odds ratio [OR], 7.33; 95% confidence interval [CI], 1.53-35.19; P =. 013) and time to surgery > 12 mo (OR, 18.21; 95% CI, 1.11-296.55; P =. 042) are independent predictors of uncontrolled seizures at the time of surgery. Focal deficit (OR, 10.25; 95% CI, 3.16-33.28; P <. 001) is an independent predictor of inability to work at the time of surgery. History of epileptic seizures at the time of surgery (OR, 7.61; 95% CI, 1.67-85.42; P =. 003) and partial resection of the CA and/or of the hemosiderin rim (OR, 12.02; 95% CI, 3.01-48.13; P <. 001) are independent predictors of uncontrolled seizures postoperatively. Inability to work at the time of surgery (OR, 19.54; 95% CI, 1.90-425.48; P =. 050), Karnofsky Performance Status ≤ 70 (OR, 51.20; 95% CI, 1.20-2175.37; P =. 039), uncontrolled seizures postoperatively (OR, 105.33; 95% CI, 4.32-2566.27; P =. 004), and worsening of cognitive functions postoperatively (OR, 13.71; 95% CI, 1.06-176.66; P =. 045) are independent predictors of inability to work postoperatively. CONCLUSION: The functional-based resection using intraoperative functional brain mapping allows safe resection of CA and the peripheral hemosiderin rim located within or close to eloquent brain areas.

Published
2019

11. Magnetic resonance imaging-based robotic radiosurgery of arteriovenous malformations

Author

Greve, T, Ehret, F, Thorsteinsdottir, J, Tonn, JC, Schichor, C, and Muacevic, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: CyberKnife offers purely MRI-based treatment planning without the need for stereotactically acquired DSA. The literature on CyberKnife treatment of cerebral AVMs is sparse. Here, a large series focusing on cerebral AVMs treated by the frameless CyberKnife stereotactic radiosurgery (SRS) system[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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12. Outcome changes in elective anterior circulation aneurysm surgery over the last two decades due to technical improvements

Author

Siller, S, Bernasconi, P, Kunz, M, Schwarting, J, Tonn, JC, Schichor, C, and Thorsteinsdottir, J

Subjects
ddc: 610, genetic structures, 610 Medical sciences, Medicine, eye diseases
Abstract

Objective: Over the last 20 years, several periprocedural adjuncts for elective surgical aneurysm treatment have been introduced to increase safety and efficacy, notably the spread of intraoperative neurophysiological monitoring in the late-1990s, implementation of ICG-videoangiography (ICG-VAG) in [for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Published
2021
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14. OC-0078 Impact of surgery and PET-guided radiotherapy in therapy management of cavernous sinus meningioma

Author

Hadi, I., primary, Biczok, A., additional, Terpolilli, N., additional, Thorsteinsdottir, J., additional, Forbrig, R., additional, Albert, N.L., additional, Yanchovski, P., additional, Zollner, B., additional, Bodensohn, R., additional, Corradini, S., additional, Bartenstein, P., additional, Belka, C., additional, Tonn, J., additional, Schichor, C., additional, and Niyazi, M., additional

Published
2021
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18. DNA methylation profiling to predict recurrence risk in meningioma: development and validation of a nomogram to optimize clinical management

Author

Nassiri F., Mamatjan Y., Suppiah S., Badhiwala J. H., Mansouri S., Karimi S., Saarela O., Poisson L., Gepfner-Tuma I., Schittenhelm J., Ng H. -K., Noushmehr H., Harter P., Baumgarten P., Weller M., Preusser M., Herold-Mende C., Tatagiba M., Tabatabai G., Sahm F., Von Deimling A., Aldape K., Au K., Barnhartz-Sloan J., Bi W. L., Brastianos P. K., Butowski N., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Dunn I. F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C. O., Horbinski C., Huang R. Y., James D., Jenkinson M. D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Malta T. M., Mawrin C., McDermott M., Munoz D., Perry A., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N. O., Selman W., Sloan A., Spears J., Snyder J., Tirapelli D., Tonn J. C., Tsang D., Vogelbaum M. A., Wen P. Y., Walbert T., Westphal M., Workewych A. M., Zadeh G., Aldape K. D., Nassiri F., Mamatjan Y., Suppiah S., Badhiwala J.H., Mansouri S., Karimi S., Saarela O., Poisson L., Gepfner-Tuma I., Schittenhelm J., Ng H.-K., Noushmehr H., Harter P., Baumgarten P., Weller M., Preusser M., Herold-Mende C., Tatagiba M., Tabatabai G., Sahm F., Von Deimling A., Aldape K., Au K., Barnhartz-Sloan J., Bi W.L., Brastianos P.K., Butowski N., Carlotti C., Cusimano M.D., Dimeco F., Drummond K., Dunn I.F., Galanis E., Giannini C., Goldbrunner R., Griffith B., Hashizume R., Hanemann C.O., Horbinski C., Huang R.Y., James D., Jenkinson M.D., Jungk C., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Malta T.M., Mawrin C., McDermott M., Munoz D., Perry A., Pirouzmand F., Poisson L.M., Pollo B., Raleigh D., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N.O., Selman W., Sloan A., Spears J., Snyder J., Tirapelli D., Tonn J.C., Tsang D., Vogelbaum M.A., Wen P.Y., Walbert T., Westphal M., Workewych A.M., Zadeh G., and Aldape K.D.

Subjects
Oncology, Cancer Research, medicine.medical_specialty, recurrence, predictor, ESTUDOS DE VALIDAÇÃO, Meningioma, nomogram, Internal medicine, medicine, Biomarkers, Tumor, Meningeal Neoplasms, Humans, Survival rate, Retrospective Studies, Oncotype DX Breast Cancer Assay, business.industry, Hazard ratio, Cancer, Disease Management, Retrospective cohort study, Nomogram, DNA Methylation, medicine.disease, Prognosis, Gene Expression Regulation, Neoplastic, Survival Rate, Clinical research, Basic and Translational Investigations, Neurology (clinical), methylation, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract

Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection of patients who would benefit from adjuvant radiotherapy to delay recurrence. We aimed to develop an individualized prediction model of early recurrence risk combining clinical and molecular factors in meningioma. Methods DNA methylation profiles of clinically annotated tumor samples across multiple institutions were used to develop a methylome model of 5-year recurrence-free survival (RFS). Subsequently, a 5-year meningioma recurrence score was generated using a nomogram that integrated the methylome model with established prognostic clinical factors. Performance of both models was evaluated and compared with standard-of-care models using multiple independent cohorts. Results The methylome-based predictor of 5-year RFS performed favorably compared with a grade-based predictor when tested using the 3 validation cohorts (ΔAUC = 0.10, 95% CI: 0.03–0.018) and was independently associated with RFS after adjusting for histopathologic grade, extent of resection, and burden of copy number alterations (hazard ratio 3.6, 95% CI: 1.8–7.2, P < 0.001). A nomogram combining the methylome predictor with clinical factors demonstrated greater discrimination than a nomogram using clinical factors alone in 2 independent validation cohorts (ΔAUC = 0.25, 95% CI: 0.22–0.27) and resulted in 2 groups with distinct recurrence patterns (hazard ratio 7.7, 95% CI: 5.3–11.1, P < 0.001) with clinical implications. Conclusions The models developed and validated in this study provide important prognostic information not captured by previously established clinical and molecular factors which could be used to individualize decisions regarding postoperative therapeutic interventions, in particular whether to treat patients with adjuvant radiotherapy versus observation alone.

Published
2019

19. Advances in multidisciplinary therapy for meningiomas

Author

Brastianos P. K., Galanis E., Butowski N., Chan J. W., Dunn I. F., Goldbrunner R., Herold-Mende C., Ippen F. M., Mawrin C., McDermott M. W., Sloan A., Snyder J., Tabatabai G., Tatagiba M., Tonn J. C., Wen P. Y., Aldape K., Nassiri F., Zadeh G., Jenkinson M. D., Raleigh D. R., Au K., Barnhartz-Sloan J., Bi W. L., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Giannini C., Griffith B., Hashizume R., Hanemann C. O., Horbinski C., Huang R. Y., James D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mansouri A., Munoz D., Noushmehr H., Ng H. -K., Perry A., Pirouzmand F., Poisson L. M., Pollo B., Sahm F., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N. O., Selman W., Spears J., Suppiah S., Tirapelli D., Tsang D., Vogelbaum M. A., Deimling A. V., Walbert T., Westphal M., Workewych A. M., Brastianos P.K., Galanis E., Butowski N., Chan J.W., Dunn I.F., Goldbrunner R., Herold-Mende C., Ippen F.M., Mawrin C., McDermott M.W., Sloan A., Snyder J., Tabatabai G., Tatagiba M., Tonn J.C., Wen P.Y., Aldape K., Nassiri F., Zadeh G., Jenkinson M.D., Raleigh D.R., Au K., Barnhartz-Sloan J., Bi W.L., Carlotti C., Cusimano M.D., Dimeco F., Drummond K., Giannini C., Griffith B., Hashizume R., Hanemann C.O., Horbinski C., Huang R.Y., James D., Jungk C., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Mamatjan Y., Mansouri A., Munoz D., Noushmehr H., Ng H.-K., Perry A., Pirouzmand F., Poisson L.M., Pollo B., Sahm F., Saladino A., Santarius T., Schichor C., Schultz D., Schmidt N.O., Selman W., Spears J., Suppiah S., Tirapelli D., Tsang D., Vogelbaum M.A., Deimling A.V., Walbert T., Westphal M., and Workewych A.M.

Subjects
Oncology, Cancer Research, medicine.medical_treatment, Supplement Articles, meningioma, Systemic therapy, surgery, 0302 clinical medicine, Meningeal Neoplasms, Trabectedin, Cancer, clinical trial, targeted therapy, Prognosis, Combined Modality Therapy, 3. Good health, 6.1 Pharmaceuticals, 030220 oncology & carcinogenesis, International Consortium on Meningiomas, Patient Safety, Meningioma, medicine.drug, medicine.medical_specialty, Oncology and Carcinogenesis, Antineoplastic Agents, Radiosurgery, 03 medical and health sciences, Internal medicine, medicine, otorhinolaryngologic diseases, Humans, Meningeal Neoplasm, Oncology & Carcinogenesis, neoplasms, business.industry, Neurosciences, Evaluation of treatments and therapeutic interventions, medicine.disease, RADIOTERAPIA, Brain Disorders, nervous system diseases, Clinical trial, Radiation therapy, radiation, Neurology (clinical), Cranial Irradiation, business, 030217 neurology & neurosurgery
Abstract

Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.

Published
2019

20. Imaging and diagnostic advances for intracranial meningiomas

Author

Huang R. Y., Bi W. L., Griffith B., Kaufmann T. J., La Fougere C., Schmidt N. O., Tonn J. C., Vogelbaum M. A., Wen P. Y., Aldape K., Nassiri F., Zadeh G., Dunn I. F., Au K., Barnhartz-Sloan J., Brastianos P. K., Butowski N., Carlotti C., Cusimano M. D., Dimeco F., Drummond K., Galanis E., Giannini C., Goldbrunner R., Hashizume R., Hanemann C. O., Herold-Mende C., Horbinski C., James D., Jenkinson M. D., Jungk C., Kaufman T. J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J. C., Mamatjan Y., Mansouri A., Mawrin C., McDermott M., Munoz D., Noushmehr H., Ng H. -K., Perry A., Pirouzmand F., Poisson L. M., Pollo B., Raleigh D., Sahm F., Saladino A., Santarius T., Schichor C., Schultz D., Selman W., Sloan A., Spears J., Snyder J., Suppiah S., Tabatabai G., Tatagiba M., Tirapelli D., Tsang D., Deimling A. V., Walbert T., Westphal M., Workewych A. M., Huang R.Y., Bi W.L., Griffith B., Kaufmann T.J., La Fougere C., Schmidt N.O., Tonn J.C., Vogelbaum M.A., Wen P.Y., Aldape K., Nassiri F., Zadeh G., Dunn I.F., Au K., Barnhartz-Sloan J., Brastianos P.K., Butowski N., Carlotti C., Cusimano M.D., Dimeco F., Drummond K., Galanis E., Giannini C., Goldbrunner R., Hashizume R., Hanemann C.O., Herold-Mende C., Horbinski C., James D., Jenkinson M.D., Jungk C., Kaufman T.J., Krischek B., Lachance D., Lafougere C., Lee I., Liu J.C., Mamatjan Y., Mansouri A., Mawrin C., McDermott M., Munoz D., Noushmehr H., Ng H.-K., Perry A., Pirouzmand F., Poisson L.M., Pollo B., Raleigh D., Sahm F., Saladino A., Santarius T., Schichor C., Schultz D., Selman W., Sloan A., Spears J., Snyder J., Suppiah S., Tabatabai G., Tatagiba M., Tirapelli D., Tsang D., Deimling A.V., Walbert T., Westphal M., and Workewych A.M.

Subjects
Cancer Research, medicine.medical_specialty, Neuroimaging, Supplement Articles, Multimodal Imaging, perfusion, Meningioma, 03 medical and health sciences, 0302 clinical medicine, Medical imaging, medicine, Meningeal Neoplasms, Humans, Meningeal Neoplasm, Radiation treatment planning, medicine.diagnostic_test, business.industry, imaging, Magnetic resonance imaging, medicine.disease, radiology, 3. Good health, Tumor detection, RADIOLOGIA, PET, Oncology, 030220 oncology & carcinogenesis, Radiological weapon, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery, CT, MRI
Abstract

The archetypal imaging characteristics of meningiomas are among the most stereotypic of all central nervous system (CNS) tumors. In the era of plain film and ventriculography, imaging was only performed if a mass was suspected, and their results were more suggestive than definitive. Following more than a century of technological development, we can now rely on imaging to non-invasively diagnose meningioma with great confidence and precisely delineate the locations of these tumors relative to their surrounding structures to inform treatment planning. Asymptomatic meningiomas may be identified and their growth monitored over time; moreover, imaging routinely serves as an essential tool to survey tumor burden at various stages during the course of treatment, thereby providing guidance on their effectiveness or the need for further intervention. Modern radiological techniques are expanding the power of imaging from tumor detection and monitoring to include extraction of biologic information from advanced analysis of radiological parameters. These contemporary approaches have led to promising attempts to predict tumor grade and, in turn, contribute prognostic data. In this supplement article, we review important current and future aspects of imaging in the diagnosis and management of meningioma, including conventional and advanced imaging techniques using CT, MRI, and nuclear medicine.

Published
2019

21. Patients’ decision-making in elective intracranial aneurysma treatment – bias of initial counselling (e.g. 'anchoring effect')?

Author

Siller, S, Kunz, M, Thorsteinsdottir, J, Dorn, F, Liebig, T, Tonn, JC, and Schichor, C

Subjects
ddc: 610, genetic structures, 610 Medical sciences, Medicine
Abstract

Objective: Interdisciplinary neurovascular boards (INVB) are deemed to find the optimum treatment modality in elective intracranial aneurysma repair (EIAR) for each individual patient. However, if risk estimation and prospect of therapeutic success are judged similar for microsurgical or interventional[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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22. Brain invasion is an independent risk factor for preoperative seizures in meningioma WHO grade I and II patients

Author

Biczok, A, Thorsteinsdottir, J, Egensperger, R, Suchorska, B, Terpolilli, NA, Tonn, JC, and Schichor, C

Subjects
ddc: 610, otorhinolaryngologic diseases, 610 Medical sciences, Medicine, neoplasms, nervous system diseases
Abstract

Objective: Preoperative seizures are a common symptom in meningioma patients. Known risk factors include radiological features, localization but also WHO grading. Recently, brain invasion was added as an independent criterion for WHO II meningioma and its clinical importance was questioned in subsequent[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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25. Intraoperative Computed Tomography

Author

Tonn, J. C., primary, Schichor, C., additional, Schnell, O., additional, Zausinger, S., additional, Uhl, E., additional, Morhard, D., additional, and Reiser, M., additional

Published
2010
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29. Significance of CSF markers for detection of ventriculitis in patients with EVD after traumatic brain injury

Author

Lenski, M, Biczok, A, Schichor, C, Briegel, J, Tonn, JC, and Thon, N

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: The aim of this study was to investigate in patients with traumatic brain injury and external ventricular drain the diagnostic potential of inflammatory markers in cerebro-spinal fluid (CSF) and serum (S) (CSF_IL-6, CSF_total leucocyte count, CSF_protein, S_CRP, S_white[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Published
2019
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32. Prognostic value of cerebrospinal fluid markers for shunt-dependency in patients with aneurysmal subarachnoid hemorrhage

Author

Lenski, M, Biczok, A, Schichor, C, Tonn, JC, Huge, V, and Thon, N

Subjects
ddc: 610, cardiovascular diseases, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: Chronic hydrocephalus malresorptivus is a common complication after aneurysmal subarachnoidal hemorrhage (SAH). Aim of this study was to define the potential of cerebrospinal fluid markers (CSF) markers for predicting shunt dependency after SAH. Methods: This single center analysis included[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018
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33. A new bilateral motor threshold criterion for corticobulbar MEP has superior predictive value than previously used criteria

Author

Greve, T, Wang, L, Tonn, JC, Schichor, C, and Szelényi, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Intraoperatively, facial nerve (FN) function is assessed with corticobulbar Motor Evoked Potentials (FN-coMEP). MEP-amplitude decrement and increase in motor threshold (MT) serve as warning criteria. A novel threshold criterion for extremity muscle MEP compares final-to-baseline motor threshold[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Published
2018
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37. Modified motor threshold criterion for intraoperative corticobulbar MEPs for prediction of postoperative facial nerve outcome

Author

Greve, T, Wang, L, Tonn, JC, Rachinger, W, Schichor, C, and Szelényi, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Intraoperatively, facial nerve (FN) function is assessed with direct electrical stimulation, observation of spontaneous activity and corticobulbar Motor Evoked Potentials (FN-coMEP). MEP-amplitude decrement and increase in motor threshold (MT) serve as warning criteria. A novel threshold [for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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38. Double-room CT scanner with sliding gantry for intraoperative imaging in neurosurgical interventions

Author

Lenski, M, Hofereiter, J, Terpolilli, N, Zausinger, S, Tonn, JC, Kreth, FW, and Schichor, C

Subjects
ddc: 610, 610 Medical sciences, Medicine, health care economics and organizations
Abstract

Objective: The growing demand for short turnaround time and cost effectiveness in operating room management also affects intraoperative imaging and the management of its complex and expensive devices. Aim of this study was to examine our experience with a series of patients, treated with aid of a new[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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39. Low-dose versus therapeutic range intravenous unfractionated heparin administration in the treatment of patients with severe aneurysmal SAH

Author

Kunz, M, Nell, C, Schniepp, R, Dorn, F, Tonn, JC, Pfister, HW, and Schichor, C

Subjects
ddc: 610, cardiovascular diseases, 610 Medical sciences, Medicine, nervous system diseases
Abstract

Objective: After severe aneurysmal subarachnoid hemorrhage (SAH) intensive care treatment necessitates intravenous heparin administration to prevent thromboembolic events. However, data on optimized administration dosages of heparin to prevent thrombembolism but also to avoid the risk of bleeding complications[for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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40. Introduction of intraoperative monitoring does not necessarily improve outcome in elective aneurysm clipping

Author

Greve, T, Stöcklein, V, Tonn, JC, and Schichor, C

Subjects
ddc: 610, digestive, oral, and skin physiology, education, 610 Medical sciences, Medicine, health care economics and organizations
Abstract

Objective: Intraoperative neuromonitoring (IOM), particularly somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) evolved as standard of care in a variety of neurosurgical procedures. However, impact of IOM on outcome of elective microsurgical clipping of unruptured intracranial [for full text, please go to the a.m. URL], 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS)

Published
2017
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44. 28 A systematic review in quality of life of patients with meningiomas: Effort towards developing a disease-specific questionnaire

Author

Mansouri, A., primary, Shin Cheung, V. Lam, additional, Karmur, B., additional, Shin Cheung, J. Lam, additional, Hachem, L., additional, Taslimi, S., additional, Nassiri, F., additional, Suppiah, S., additional, Drummond, K., additional, Walbert, T., additional, Goldbrunner, R., additional, Santarius, Y., additional, Jenkinson, M. D., additional, Snyder, J., additional, Lee, I., additional, Devine, K., additional, Schichor, C., additional, Aldape, K. D., additional, and Zadeh, G., additional

Published
2018
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49. Cranial nerve and brainstem compression syndromes in unruptured intracranial aneurysms: long-term results

Author

Greve, T, Kunz, M, Stöcklein, V, Janssen, H, Tonn, JC, and Schichor, C

Subjects
symptomatic UIA, ddc: 610, compression syndromes, 610 Medical sciences, Medicine, long-term results
Abstract

Objective: In symptomatic unruptured intracranial aneurysms (UIA), treatment, based on interdisciplinary decision-making is standard of care. However, data on long-term functional outcome are sparse. We therefore analyzed our in-house database for patients, treated on symptomatic UIAs either microsurgically[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016
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50. Diffusion tensor imaging of optical pathway alterations by lesions of the anterior skull base

Author

Oehlschlägel, F, Rachinger, W, Brem, C, Tonn, JC, and Schichor, C

Subjects
optical nerve, anterior skull base, ddc: 610, nervous system, Diffusion Tensor imaging, 610 Medical sciences, Medicine, behavioral disciplines and activities
Abstract

Objective: High resolution MRI Diffusion Tensor imaging (DTI) was shown to be clinically useful in cranial nerve compression syndromes like trigeminus neuralgia. Therefore it was tempting to investigate structural alterations in the optical pathway accordingly. In our prospective study we analyzed DTI[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Published
2016
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