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3,654 results on '"Schiöth, Helgi"'

20. Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics

Author

Desai, Trishna A., Hedman, Åsa K., Dimitriou, Marios, Koprulu, Mine, Figiel, Sandy, Yin, Wencheng, Johansson, Mattias, Watts, Eleanor L., Atkins, Joshua R., Sokolov, Aleksandr V., Schiöth, Helgi B., Gunter, Marc J., Tsilidis, Konstantinos K., Martin, Richard M., Pietzner, Maik, Langenberg, Claudia, Mills, Ian G., Lamb, Alastair D., Mälarstig, Anders, Key, Tim J., Travis, Ruth C., and Smith-Byrne, Karl

Published
2024
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36. Inulin as a Biopolymer; Chemical Structure, Anticancer Effects, Nutraceutical Potential and Industrial Applications: A Comprehensive Review.

Author

Karimi, Isaac, Ghowsi, Mahnaz, Mohammed, Layth Jasim, Haidari, Zohreh, Nazari, Kosar, and Schiöth, Helgi B.

Subjects
SHORT-chain fatty acids, ALIMENTARY canal, INULIN, FRUCTANS, INDUSTRIAL capacity, PREBIOTICS
Abstract

Inulin is a versatile biopolymer that is non-digestible in the upper alimentary tract and acts as a bifidogenic prebiotic which selectively promotes gut health and modulates gut–organ axes through short-chain fatty acids and possibly yet-to-be-known interactions. Inulin usage as a fiber ingredient in food has been approved by the FDA since June 2018 and it is predicted that the universal inulin market demand will skyrocket in the near future because of its novel applications in health and diseases. This comprehensive review outlines the known applications of inulin in various disciplines ranging from medicine to industry, covering its benefits in gut health and diseases, metabolism, drug delivery, therapeutic pharmacology, nutrition, and the prebiotics industry. Furthermore, this review acknowledges the attention of researchers to knowledge gaps regarding the usages of inulin as a key modulator in the gut–organ axes. [ABSTRACT FROM AUTHOR]

Published
2025
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37. Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties.

Author

Muslim, Wisam Taher, Mohammad, Layth Jasim, Naji, Munaf M., Karimi, Isaac, Al-Sabti, Matheel D., Jabir, Majid, Najm, Mazin A. A., and Schiöth, Helgi B.

Subjects
DRUG side effects, PROPARGYL bromide, MITOGEN-activated protein kinases, THIN layer chromatography, NUCLEAR magnetic resonance, XANTHONE
Abstract

Background: Xanthones are dubbed as putative lead-like molecules for cancer drug design and discovery. This study was aimed at the synthesis, characterization, and in silico target fishing of novel xanthone derivatives. Methods: The products of reactions of xanthydrol with urea, thiourea, and thiosemicarbazide reacted with α-haloketones to prepare the thiazolone compounds. Xanthydrol reacted sequentially with ethyl chloroacetate, hydrazine, carbon disulfide, and α-haloketones to prepare the dithiolane. The xanthydrol reacted with propargyl bromide and it submitted to click reaction with azide to prepare triazole ring. Results: Finally, four novel xanthones derivatives including (E)-2-(2-(9 H -xanthen-9-yl)hydrazono)-1,3-dithiolan-4-one (L3), 2-(2-(9 H -xanthen-9-yl)hydrazinyl)thiazol-5(4 H)-one (L5), 2-(9 H -xanthen-9-ylamino)thiazol-5(4H)-one (L7), and 4-((9 H -xanthen-9-yloxy)methyl)-1-(4-nitrophenyl)-1 H -1,2,3-triazole (L9) were synthesized and characterized using thin layer chromatography, Fourier-transform infrared spectroscopy, and nuclear magnetic resonance (1H and 13C). ADMET, Pfizer filter, adverse drug reaction, toxicity, antitarget interaction profiles, target fishing, kinase target screening, molecular docking validation, and protein and gene network analysis were computed for derivatives. Ligands obeyed Pfizer filter for drug-likeness, while all ligands were categorized as toxic chemicals. Major targets of all ligands were predicted to be kinases including Haspin, WEE2, and PIM3. Mitogen-activated protein kinase 1 was the hub gene of target kinase network of all derivatives. All the ligands were predicted to show hepatotoxic potentials, while L7 presented cardiac toxicity. Conclusion: Acute leukemic T-cells were one of the top predicted tumor cell lines for these ligands. The possible antileukemic effects of synthesized xanthone derivatives are potentially very interesting and warrant further studies. [ABSTRACT FROM AUTHOR]

Published
2025
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38. Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction.

Author

Aguggia, Julieta, Fernandez, Gimena, Cassano, Daniela, Mustafá, Emilio R, Rodríguez, Silvia S, Cantel, Sonia, Fehrentz, Jean-Alain, Raingo, Jesica, Schiöth, Helgi B, Habib, Abdella M, Francesco, Pablo N De, and Perello, Mario

Subjects
GLUCAGON-like peptide-1 receptor, G protein coupled receptors, CALCIUM channels, GHRELIN, NEURONS
Abstract

The GH secretagogue receptor (GHSR) and the glucagon-like peptide-1 receptor (GLP-1R) are G protein-coupled receptors with critical, yet opposite, roles in regulating energy balance. Interestingly, these receptors are expressed in overlapping brain regions. However, the extent to which they target the same neurons and engage in molecular crosstalk remains unclear. To explore the potential colocalization of GHSR and GLP-1R in specific neurons, we performed detailed mapping of cells positive for both receptors using GHSR-eGFP reporter mice or wild-type mice infused with fluorescent ghrelin, alongside an anti-GLP-1R antibody. We found that GHSR+ and GLP-1R+ cells are largely segregated in the mouse brain. The highest overlap was observed in the hypothalamic arcuate nucleus, where 15% to 20% of GHSR+ cells were also GLP-1R+ cells. Additionally, we examined RNA-sequencing datasets from mouse and human brains to assess the fraction and distribution of neurons expressing both receptors, finding that double-positive Ghsr+/Glp1r+ cells are highly segregated, with a small subset of double-positive Ghsr+/Glp1r+ cells representing <10% of all Ghsr+ or Glp1r+ cells, primarily enriched in the hypothalamus. Furthermore, we conducted functional studies using patch-clamp recordings in a heterologous expression system to assess potential crosstalk in regulating presynaptic calcium channels. We provide the first evidence that liraglutide-evoked GLP-1R activity inhibits presynaptic channels, and that the presence of one GPCR attenuates the inhibitory effects of ligand-evoked activity mediated by the other on presynaptic calcium channels. In conclusion, while GHSR and GLP-1R can engage in molecular crosstalk, they are largely segregated across most neuronal types within the brain. [ABSTRACT FROM AUTHOR]

Published
2025
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