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310 results on '"Scherber, Robyn M"'

1. The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Luque, Laura F Mendez, Avelar-Barragan, Julio, Nguyen, Hellen, Nguyen, Jenny, Soyfer, Eli M, Liu, Jiarui, Chen, Jane H, Mehrotra, Nitya, Huang, Xin, Kosiorek, Heidi E, Dueck, Amylou, Himstead, Alexander, Heide, Elena, Lem, Melinda, Alaoui, Kenza El, Mas, Eduard, Scherber, Robyn M, Mesa, Ruben A, Whiteson, Katrine L, Odegaard, Andrew, and Fleischman, Angela G

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Clinical Trials and Supportive Activities, Dietary Supplements, Complementary and Integrative Health, Hematology, Nutrition, Prevention, Behavioral and Social Science, Clinical Research, Humans, United States, Pilot Projects, Feasibility Studies, Diet, Mediterranean, Myeloproliferative Disorders, Inflammation, Neoplasms, Nutrients
Abstract

PurposeChronic inflammation is integral to myeloproliferative neoplasm (MPN) pathogenesis. JAK inhibitors reduce cytokine levels, but not without significant side effects. Nutrition is a low-risk approach to reduce inflammation and ameliorate symptoms in MPN. We performed a randomized, parallel-arm study to determine the feasibility of an education-focused Mediterranean diet intervention among patients with MPN.Experimental designWe randomly assigned patients with MPN to either a Mediterranean diet or standard U.S. Dietary Guidelines for Americans (USDA). Groups received equal but separate education with registered dietician counseling and written dietary resources. Patients were prospectively followed for feasibility, adherence, and symptom burden assessments. Biological samples were collected at four timepoints during the 15-week study to explore changes in inflammatory biomarkers and gut microbiome.ResultsThe Mediterranean diet was as easy to follow for patients with MPN as the standard USDA diet. Approximately 80% of the patients in the Mediterranean diet group achieved a Mediterranean Diet Adherence Score of ≥8 throughout the entire active intervention period, whereas less than 50% of the USDA group achieved a score of ≥8 at any timepoint. Improvement in symptom burden was observed in both diet groups. No significant changes were observed in inflammatory cytokines. The diversity and composition of the gut microbiome remained stable throughout the duration of the intervention.ConclusionsWith dietician counseling and written education, patients with MPN can adhere to a Mediterranean eating pattern. Diet interventions may be further developed as a component of MPN care, and potentially incorporated into the management of other hematologic conditions.SignificanceDiet is a central tenant of management of chronic conditions characterized by subclinical inflammation, such as cardiovascular disease, but has not entered the treatment algorithm for clonal hematologic disorders. Here, we establish that a Mediterranean diet intervention is feasible in the MPN patient population and can improve symptom burden. These findings warrant large dietary interventions in patients with hematologic disorders to test the impact of diet on clinical outcomes.

Published
2024

3. Precision immunotherapy, mutational landscape, and emerging tools to optimize clinical outcomes in patients with classical myeloproliferative neoplasms

Author

Mughal, Tariq I, Lion, Thomas, Abdel‐Wahab, Omar, Mesa, Ruben, Scherber, Robyn M, Perrotti, Danilo, Mauro, Michael, Verstovsek, Srdan, Saglio, Giuseppe, Van Etten, Richard A, and Kralovics, Robert

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Hematology, Cancer, Rare Diseases, Good Health and Well Being, Amino Acid Substitution, Fusion Proteins, bcr-abl, Hematologic Neoplasms, Humans, Immunotherapy, Janus Kinase 2, Mutation, Missense, Myeloproliferative Disorders, Precision Medicine, Translational Research, Biomedical, Chronic myeloroliferative neoplasms, immunotherapy, genomics, treatment, Cardiorespiratory Medicine and Haematology, Immunology, Cardiovascular medicine and haematology
Abstract

Following the 47th American Society of Hematology Meeting in 2005, the late John Goldman and Tariq Mughal commenced a conference, the 1st Post-ASH Workshop, which brought together clinicians and scientists, to accelerate the adoption of new therapies for patients with myeloproliferative neoplasms (MPNs). The concept began with recognition of the CML success story following imatinib therapy, the discovery of JAK2V617F , and the demonstration that BCR-ABL1-negative MPNs are driven by abnormal JAK2 activation. This review is based on the presentations and deliberations at the XIIth Post-ASH Workshop on BCR-ABL1 positive and negative MPNs that took place on December 12 to 13, 2017, in Atlanta, Georgia, immediately following the 59th American Society of Hematology Meeting. We have selected some of the translational research and clinical topics, rather than an account of the proceedings. We discuss the role of immunotherapy in MPNs and the impact of the mutational landscape on TKI treatment in CML. We also consider how we might reduce TKI cardiovascular side effects, the potential role of nutrition as adjunctive nonpharmacologic intervention to reduce chronic inflammation in MPNs, and novel investigational therapies for MPNs.

Published
2018

4. The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies.

Author

Craver, Brianna M, El Alaoui, Kenza, Scherber, Robyn M, and Fleischman, Angela G

Subjects
clonal hematopoiesis, hematopoietic stem cells, inflammation, myeloid malignancy, symptom burden, Stem Cell Research, Cancer, Hematology, Regenerative Medicine, 2.1 Biological and endogenous factors, Inflammatory and Immune System, Oncology and Carcinogenesis
Abstract

Hematopoietic stem cells (HSCs) maintain an organism's immune system for a lifetime, and derangements in HSC proliferation and differentiation result in hematologic malignancies. Chronic inflammation plays a contributory if not causal role in HSC dysfunction. Inflammation induces HSC exhaustion, which promotes the emergence of mutant clones that may be resistant to an inflammatory microenvironment; this likely promotes the onset of a myeloid hematologic malignancy. Inflammatory cytokines are characteristically high in patients with myeloid malignancies and are linked to disease initiation, symptom burden, disease progression, and worsened prognostic survival. This review will cover our current understanding of the role of inflammation in the initiation, progression, and complications of myeloid hematologic malignancies, drawing from clinical studies as well as murine models. We will also highlight inflammation as a therapeutic target in hematologic malignancies.

Published
2018

6. Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis

Author

Ronner, Lukas, Podoltsev, Nikolai, Gotlib, Jason, Heaney, Mark L., Kuykendall, Andrew T., O'Connell, Casey, Shammo, Jamile, Fleischman, Angela G., Scherber, Robyn M., Mesa, Ruben, Yacoub, Abdulraheem, Perkins, Cecelia, Meckstroth, Shelby, Behlman, Lindsey, Chiaramonte, Matthew, Salehi, Mahta, Ziadkhanpour, Kimia, Nguyen, Hellen, Siwoski, Olivia, Hung, Annie Kwok, Janania Martinez, Michelle, Nguyen, Jenny, Patel, Sagar, Kollipara, Revathi, Dave, Ami, Randall, Megan, Grant, Michael, Harrison, Mitchell, Fernandez Soto, Paola, Tremblay, Douglas, Hoffman, Ronald, Moshier, Erin, and Mascarenhas, John

Published
2020
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8. FIGURE 6 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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9. FIGURE 5 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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10. Supplementary Figure 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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11. Supplementary Table 4 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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12. FIGURE 4 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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13. USDA diet educational materials from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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14. Supplementary Table 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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15. Data from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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16. The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, additional, Nguyen, Hellen, additional, Nguyen, Jenny, additional, Soyfer, Eli M., additional, Liu, Jiarui, additional, Chen, Jane H., additional, Mehrotra, Nitya, additional, Huang, Xin, additional, Kosiorek, Heidi E., additional, Dueck, Amylou, additional, Himstead, Alexander, additional, Heide, Elena, additional, Lem, Melinda, additional, El Alaoui, Kenza, additional, Mas, Eduard, additional, Scherber, Robyn M., additional, Mesa, Ruben A., additional, Whiteson, Katrine L., additional, Odegaard, Andrew, additional, and Fleischman, Angela G., additional

Published
2024
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17. Supplementary Figure 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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18. FIGURE 3 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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19. TABLE 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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20. Supplementary Figure 3 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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21. Mediterranean Diet education materials from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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22. FIGURE 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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23. Supplementary Table 1 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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24. TABLE 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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25. FIGURE 2 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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26. Surveys from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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27. Supplementary Table 3 from The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence

Author

Mendez Luque, Laura F., primary, Avelar-Barragan, Julio, primary, Nguyen, Hellen, primary, Nguyen, Jenny, primary, Soyfer, Eli M., primary, Liu, Jiarui, primary, Chen, Jane H., primary, Mehrotra, Nitya, primary, Huang, Xin, primary, Kosiorek, Heidi E., primary, Dueck, Amylou, primary, Himstead, Alexander, primary, Heide, Elena, primary, Lem, Melinda, primary, El Alaoui, Kenza, primary, Mas, Eduard, primary, Scherber, Robyn M., primary, Mesa, Ruben A., primary, Whiteson, Katrine L., primary, Odegaard, Andrew, primary, and Fleischman, Angela G., primary

Published
2024
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31. The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Feasibility Phase

Author

Mendez Luque, Laura F, primary, Avelar-Barragan, Julio, additional, Nguyen, Hellen, additional, Nguyen, Jenny, additional, Soyfer, Eli, additional, Li, Jiarui, additional, Chen, Jane H, additional, Mehrotra, Nitya, additional, Kosiorek, Heidi, additional, Dueck, Amylou, additional, Himstead, Alexander, additional, Heide, Elena, additional, Lem, Melinda, additional, El Alaoui, Kenza, additional, Mas Marin, Eduard, additional, Scherber, Robyn M, additional, Mesa, Ruben A, additional, Whiteson, Katrine, additional, Odegaard, Andrew, additional, and Fleischman, Angela, additional

Published
2023
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32. Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients: retrospective assessment in 1470 patients

Author

Geyer, Holly L., Scherber, Robyn M., Dueck, Amylou C., Kiladjian, Jean-Jacques, Xiao, Zhijian, Slot, Stefanie, Zweegman, Sonja, Sackmann, Federico, Fuentes, Ana Kerguelen, Hernández-Maraver, Dolores, Döhner, Konstanze, Harrison, Claire N., Radia, Deepti, Muxi, Pablo, Besses, Carlos, Cervantes, Francisco, Johansson, Peter L., Andreasson, Bjorn, Rambaldi, Alessandro, Barbui, Tiziano, Vannucchi, Alessandro M., Passamonti, Francesco, Samuelsson, Jan, Birgegard, Gunnar, and Mesa, Ruben A.

Published
2014
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33. Targeting African American Nonsmokers to Motivate Smokers to Quit: A Qualitative Inquiry

Author

Thomas, Janet L., Scherber, Robyn M., and Stewart, Diana W.

Abstract

African Americans bear a disproportionate health burden from smoking but are less likely than other populations to engage in cessation treatment. Intervening on adult nonsmokers residing with a smoker might represent an innovative approach to motivate smokers to engage in smoking behavior change. Twelve focus groups were conducted with African American smokers (four groups, n = 27), nonsmokers (four groups, n = 26) and pairs of cohabitating smokers and nonsmokers (four groups, n = 22) to assess attitudes and/or beliefs regarding engaging a nonsmoker in the home in smoking behavior change efforts. Participants (N = 75) were middle-aged (45.1 plus or minus 3.7 years) females (68.0%) with 11.8 plus or minus 1.5 years of education. Smokers smoked 14.9 plus or minus 11.3 cigarettes per day, made 3.0 plus or minus 4.4 quit attempts in the past year, and are interested in receiving cessation assistance from a nonsmoker in their home. African American nonsmokers living with a smoker may be an appropriate target group to motivate smoking behavior change in the smoker. Suggestions for future research considerations are provided. (Contains 2 tables.)

Published
2010
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35. Quality of life independently predicts overall survival in myelofibrosis: Key insights from the COntrolled MyeloFibrosis Study with ORal Janus kinase inhibitor Treatment (COMFORT)‐I study

Author

Kosiorek, Heidi E., primary, Scherber, Robyn M., additional, Geyer, Holly L., additional, Verstovsek, Srdan, additional, Langlais, Blake T., additional, Mazza, Gina L., additional, Gotlib, Jason, additional, Gupta, Vikas, additional, Padrnos, Leslie J., additional, Palmer, Jeanne M., additional, Fleischman, Angela, additional, Mesa, Ruben A., additional, and Dueck, Amylou C., additional

Published
2022
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43. Impact of COVID19 Pandemic on an International MPN Patient Population: Survey Results from 1560 MPN Patients

Author

Palmer, Jeanne M., Mead-Harvey, Carolyn, Harrison, Claire, Dueck, Amylou C., Eckert, Ryan, Kosiorek, Heidi E., Muxi, Pablo, Pemmaraju, Naveen, Ruiz Arguelles, Guillermo, Vannucchi, Alessandro M., Gupta, Vikas, Mascarenhas, John, Taylor, Kerry, Gowin, Krisstina L., Geyer, Holly L., Shimoda, Kazuya, Kiladjian, Jean-Jacques, Komatsu, Norio, Kam Li Shan, Grace, Abello, Virginia, Gomez-Almaguer, David, Scherber, Robyn M., Jiang, Qian, Zuo, Xuelan, Huberty, Jennifer, Anderson, Lesley, Langlais, Blake T., Brazeau, Ann, Woehrle, Michelle, Mauro, Michael J., and Mesa, Ruben

Published
2020
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45. Tobacco use in the Myeloproliferative neoplasms:symptom burden, patient opinions, and care

Author

Christensen, Sarah F., Scherber, Robyn M., Mazza, Gina L., Dueck, Amylou C., Brochmann, Nana, Andersen, Christen L., Hasselbalch, Hans C., Mesa, Ruben A., Geyer, Holly L., Christensen, Sarah F., Scherber, Robyn M., Mazza, Gina L., Dueck, Amylou C., Brochmann, Nana, Andersen, Christen L., Hasselbalch, Hans C., Mesa, Ruben A., and Geyer, Holly L.

Abstract

Background: Patients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancies. The aim of this study was to analyze the association between smoking and MPN-related symptom burden and explore MPN patients’ opinions on smoking. Methods: A total of 435 patients with MPN participated in a cross-sectional internet-based survey developed by the Mayo Clinic and the Myeloproliferative Neoplasm Quality of Life Group. Patients reported their demographics, disease characteristics, tobacco use, and opinions on tobacco use. In addition, MPN-related symptoms were reported via the validated 10-item version of the Myeloproliferative Neoplasms Symptom Assessment Form. Results: Current/former smokers reported worse fatigue (mean severity 5.6 vs. 5.0, p = 0.02) and inactivity (mean severity 4.0 vs. 3.4, p = 0.03) than never smokers. Moreover, current/former smokers more frequently experienced early satiety (68.5% vs. 58.3%, p = 0.03), inactivity (79.9% vs. 71.1%, p = 0.04), and concentration difficulties (82.1% vs. 73.1%, p = 0.04). Although not significant, a higher total symptom burden was observed for current/former smokers (mean 30.4 vs. 27.0, p = 0.07). Accordingly, overall quality of life was significantly better among never smokers than current/former smokers (mean 3.5 vs. 3.9, p = 0.03). Only 43.2% of the current/former smokers reported having discussed tobacco use with their physician, and 17.5% did not believe smoking increased the risk of thrombosis. Conclusion: The current study suggests that smoking may be associated with increased prevalence and severity of MPN symptoms and underscores the need to enhance patient education and address tobacco use in the care of MPN patients.

Published
2021

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