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21 results on '"Schepman, Kees-Pieter"'

1. EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

Author

de Wit, Jaron G., Vonk, Jasper, Voskuil, Floris J., de Visscher, Sebastiaan A. H. J., Schepman, Kees-Pieter, Hooghiemstra, Wouter T. R., Linssen, Matthijs D., Elias, Sjoerd G., Halmos, Gyorgy B., Plaat, Boudewijn E. C., Doff, Jan J., Rosenthal, Eben L., Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B., van Dam, Gooitzen M., and Witjes, Max J. H.

Published
2023
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4. EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients:a phase II trial

Author

de Wit, Jaron G., Vonk, Jasper, Voskuil, Floris J., de Visscher, Sebastiaan A.H.J., Schepman, Kees Pieter, Hooghiemstra, Wouter T.R., Linssen, Matthijs D., Elias, Sjoerd G., Halmos, Gyorgy B., Plaat, Boudewijn E.C., Doff, Jan J., Rosenthal, Eben L., Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B., van Dam, Gooitzen M., Witjes, Max J.H., de Wit, Jaron G., Vonk, Jasper, Voskuil, Floris J., de Visscher, Sebastiaan A.H.J., Schepman, Kees Pieter, Hooghiemstra, Wouter T.R., Linssen, Matthijs D., Elias, Sjoerd G., Halmos, Gyorgy B., Plaat, Boudewijn E.C., Doff, Jan J., Rosenthal, Eben L., Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B., van Dam, Gooitzen M., and Witjes, Max J.H.

Abstract

Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery. Fluorescence molecular imaging (FMI) has been explored for intraoperative margin assessment, but data are limited to phase-I studies. In this single-arm phase-II study (NCT03134846), our primary endpoints were to determine the sensitivity, specificity and positive predictive value of cetuximab-800CW for tumor-positive margins detection. Secondary endpoints were safety, close margin detection rate and intrinsic cetuximab-800CW fluorescence. In 65 patients with 66 tumors, cetuximab-800CW was well-tolerated. Fluorescent spots identified in the surgical margin with signal-to-background ratios (SBR) of ≥2 identify tumor-positive margins with 100% sensitivity, 85.9% specificity, 58.3% positive predictive value, and 100% negative predictive value. An SBR of ≥1.5 identifies close margins with 70.3% sensitivity, 76.1% specificity, 60.5% positive predictive value, and 83.1% negative predictive value. Performing frozen section analysis aimed at the fluorescent spots with an SBR of ≥1.5 enables safe, intraoperative adjustment of surgical margins.

Published
2023

5. EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

Author

Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, de Wit, Jaron G, Vonk, Jasper, Voskuil, Floris J, de Visscher, Sebastiaan A H J, Schepman, Kees-Pieter, Hooghiemstra, Wouter T R, Linssen, Matthijs D, Elias, Sjoerd G, Halmos, Gyorgy B, Plaat, Boudewijn E C, Doff, Jan J, Rosenthal, Eben L, Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B, van Dam, Gooitzen M, Witjes, Max J H, Epi Kanker Team C, Cancer, JC onderzoeksprogramma Kanker, de Wit, Jaron G, Vonk, Jasper, Voskuil, Floris J, de Visscher, Sebastiaan A H J, Schepman, Kees-Pieter, Hooghiemstra, Wouter T R, Linssen, Matthijs D, Elias, Sjoerd G, Halmos, Gyorgy B, Plaat, Boudewijn E C, Doff, Jan J, Rosenthal, Eben L, Robinson, Dominic, van der Vegt, Bert, Nagengast, Wouter B, van Dam, Gooitzen M, and Witjes, Max J H

Published
2023

9. Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study

Author

Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Voskuil, Floris Jan, de Jongh, Steven Jakob, Hooghiemstra, Wouter Tjerk Rudolph, Linssen, Matthijs David, Steinkamp, Pieter Jan, de Visscher, Sebastiaan Antonius Hendrik Johannes, Schepman, Kees-Pieter, Elias, Sjoerd Geert, Meersma, Gert-Jan, Jonker, Pascal Klaas Christiaan, Doff, Jan Johannes, Jorritsma-Smit, Annelies, Nagengast, Wouter Bastiaan, van der Vegt, Bert, Robinson, Dominic James, van Dam, Gooitzen Michell, Witjes, Max Johannes Hendrikus, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Voskuil, Floris Jan, de Jongh, Steven Jakob, Hooghiemstra, Wouter Tjerk Rudolph, Linssen, Matthijs David, Steinkamp, Pieter Jan, de Visscher, Sebastiaan Antonius Hendrik Johannes, Schepman, Kees-Pieter, Elias, Sjoerd Geert, Meersma, Gert-Jan, Jonker, Pascal Klaas Christiaan, Doff, Jan Johannes, Jorritsma-Smit, Annelies, Nagengast, Wouter Bastiaan, van der Vegt, Bert, Robinson, Dominic James, van Dam, Gooitzen Michell, and Witjes, Max Johannes Hendrikus

Published
2020

11. Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study

Author

Voskuil, Floris Jan, primary, de Jongh, Steven Jakob, additional, Hooghiemstra, Wouter Tjerk Rudolph, additional, Linssen, Matthijs David, additional, Steinkamp, Pieter Jan, additional, de Visscher, Sebastiaan Antonius Hendrik J, additional, Schepman, Kees-Pieter, additional, Elias, Sjoerd Geert, additional, Meersma, Gert-Jan, additional, Jonker, Pascal Klaas Christiaan, additional, Doff, Jan Johannes, additional, Jorritsma-Smit, Annelies, additional, Nagengast, Wouter Bastiaan, additional, van der Vegt, Bert, additional, Robinson, Dominic James, additional, van Dam, Gooitzen Michell, additional, and Witjes, Max Johannes Hendrikus, additional

Published
2020
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21. Epidermal Growth Factor Receptor-Targeted Fluorescence Molecular Imaging for Postoperative Lymph Node Assessment in Patients with Oral Cancer.

Author

Vonk J, de Wit JG, Voskuil FJ, Tang YH, Hooghiemstra WTR, Linssen MD, van den Broek E, Doff JJ, de Visscher SAHJ, Schepman KP, van der Vegt B, van Dam GM, and Witjes MJH

Subjects
Cetuximab, ErbB Receptors, Humans, Lymph Node Excision, Lymph Nodes diagnostic imaging, Lymph Nodes pathology, Lymph Nodes surgery, Lymphatic Metastasis diagnostic imaging, Lymphatic Metastasis pathology, Molecular Imaging, Retrospective Studies, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Head and Neck Neoplasms pathology, Mouth Neoplasms diagnostic imaging, Mouth Neoplasms surgery
Abstract

In most oral cancer patients, surgical treatment includes resection of the primary tumor combined with excision of lymph nodes (LNs), either for staging or for treatment. All LNs harvested during surgery require tissue processing and subsequent microscopic histopathologic assessment to determine the nodal stage. In this study, we investigated the use of the fluorescent tracer cetuximab-800CW to discriminate between tumor-positive and tumor-negative LNs before histopathologic examination. Here, we report a retrospective ad hoc analysis of a clinical trial designed to evaluate the resection margin in patients with oral squamous cell carcinoma (NCT02415881). Methods: Two days before surgery, patients were intravenously administered 75 mg of cetuximab followed by 15 mg of cetuximab-800CW, an epidermal growth factor receptor-targeting fluorescent tracer. Fluorescence images of excised, formalin-fixed LNs were obtained and correlated with histopathologic assessment. Results: Fluorescence molecular imaging of 514 LNs (61 pathologically positive nodes) could detect tumor-positive LNs ex vivo with 100% sensitivity and 86.8% specificity (area under the curve, 0.98). In this cohort, the number of LNs that required microscopic assessment was decreased by 77.4%, without missing any metastases. Additionally, in 7.5% of the LNs false-positive on fluorescence imaging, we identified metastases missed by standard histopathologic analysis. Conclusion: Our findings suggest that epidermal growth factor receptor-targeted fluorescence molecular imaging can aid in the detection of LN metastases in the ex vivo setting in oral cancer patients. This image-guided concept can improve the efficacy of postoperative LN examination and identify additional metastases, thus safeguarding appropriate postoperative therapy and potentially improving prognosis., (© 2022 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2022
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