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4. Identification of new quantitative trait loci (other than the PRNP gene) modulating the scrapie incubation period in sheep

Author

Moreno, C.R., Cosseddu, G.M., Schibler, L., Roig, A., Moazami-Goudarzi, K., Andreoletti, O., Eychenne, F., Lajous, D., Schelcher, F., Cribiu, E.P., Laurent, P., Vaiman, D., and Elsen, J.M.

Subjects
Scrapie -- Risk factors, Scrapie -- Genetic aspects, Scrapie -- Research, Quantitative trait loci -- Identification and classification, Biological sciences
Abstract

Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.

Published
2008

9. Effects of pre- or postpartum selenium supplementation on selenium status in beef cows and their calves

Author

Enjalbert, F., Lebreton, P., Salat, O., and Schelcher, F.

Subjects
Selenium -- Physiological aspects, Cows -- Research, Glutathione -- Research, Peroxidase -- Research, Zoology and wildlife conservation
Abstract

The effect of Se supplementation before or after calving on Se status in deficient cows and their calves was studied using 72 beef cows in two experiments. In Exp. 1, cows calving in February or March 1997 were supplemented orally for 15 d in late pregnancy with 13.0, 32.5, or 45.5 mg of Se/d as sodium selenite. Glutathione peroxidase (GSH-Px) activities were measured in red blood cells (RBC) or plasma of cows and calves at d 15 and between d 17 and 88 after calving. In Exp. 2, cows calving in January 1997 were supplemented orally with .0, 13.0, or 32.5 mg of Se/d for 15 d postpartum, and calves were injected with 1.38 mg of Se when 2 d old and at an average age of 49 d. The GSH-Px activities were measured in 30-d-old calves and in cows and calves between d 77 and 115 after calving. In both experiments, Se supplementation resulted in adequate Se status for the dams. The increase in RBC GSH-Px activity was faster with 45.5 mg of Se/d, and GSH-Px activities remained high for up to 98 d after the end of supplementation. The improvement in Se status in calves as a result of maternal supplementation was greater in Exp. 1 than in Exp. 2, suggesting that the placental transfer of Se is more efficient than milk transfer. Prepartum oral Se supplementation of deficient beef cows with 13.0 mg of Se/d for 15 d allowed adequate Se status of dams and calves, and 45.5 mg of Se/d resulted in a faster improvement of Se status. Parenteral administration of 1.38 mg of Se to newborn calves did not sustain normal Se status in calves issued from deficient cows. Key Words: Selenium, Glutathione Peroxidase, Cows, Calves

Published
1999

13. PrPSc accumulation in myocytes from sheep incubating natural scrapie

Author

Andreoletti, O, Simon, S, Lacroux, C, Morel, N, Tabouret, G, Chabert, A, Lugan, S, Corbiere, F, Ferre, P, Foucras, G., Laude, H., Eychenne, F., Grassi, J, and Schelcher, F

Abstract

Author(s): O Andreoletti (corresponding author) [1]; S Simon [2]; C Lacroux [1]; N Morel [2]; G Tabouret [1]; A Chabert [1]; S Lugan [1]; F Corbiere [1]; P Ferre [3]; [...]

Published
2004
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14. Treatment of sarcoptic and chorioptic mange in an alpaca (Vicugna pacos) herd with a combination of topical amitraz and subcutaneous ivermectin.

Author

Castilla-Castaño, E, Herman, N, Martinelli, E, Lecru, LA, Pressanti, C, Schelcher, F, and Cadiergues, MC

Subjects
ALPACA, IVERMECTIN, MITE infestations, SARCOPTES scabiei, ACARICIDES, VETERINARY autopsy, SKIN infections
Abstract

Clinical history: An outbreak of intense pruritus and weight loss in a herd of 40 alpacas (Vicugna pacos) in the south-west of France was investigated after the death of 14 adults. One alpaca was referred to a veterinary teaching hospital for diagnosis and treatment but died soon after and one of the dead alpacas was submitted for necropsy. Clinical findings: The remaining alpacas were intensely pruritic with variably severe and extensive alopecia, erythema, lichenification and crusting on the face, ventral abdomen and distal limbs. Superficial skin scrapes from five animals revealed large numbers of Sarcoptes scabiei mites, and less frequent and numerous Chorioptes bovis mites. Coproscopic examinations revealed a median of 1,350 (min 500, max 8800) strongyle epg. The alpaca admitted for treatment was anaemic and hypoalbuminaemic. Skin scrapes revealed copious S. scabiei and C. bovis mites. The two alpacas examined post-mortem had similar skin lesions to those examined on-farm and were cachexic. One had lung lesions attributed to protostrongylid infestation and its liver contained numerous Dicrocoelium spp. adults. Diagnosis: Sarcoptic and chorioptic mange with secondary superficial bacterial skin infection, associated with severe internal parasitism and underfeeding. Treatment and outcome: All 25 alpacas were treated topically with a 3% chlorhexidine shampoo followed by a 0.025% amitraz wash at the initial visit and then 1, 2, 3, 7 and 9 weeks later. A systemic treatment with S/C 500 µg/kg ivermectin was administered at the initial visit and then 2, 7 and 9 weeks later. The alpacas were treated orally with 50 mg/kg praziquantel to control dicrocoeliosis. Nutritional measures, including increased pasture area and supplemental feeding were simultaneously implemented. Pruritus was reduced 1 week after the start of treatment and had resolved after 2 weeks. After 9 weeks, skin lesions were markedly improved. Six months after the initial visit, skin lesions entirely resolved and superficial skin scrapes, taken from half of the animals, were negative for mites. Clinical relevance: This is the first report of the use of two acaricides combined with a chlorhexidine shampoo to successfully treat simultaneous sarcoptic and chorioptic mange in alpacas. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Use of Monoclonal Antibodies for Immunohistochemical Study of Bovine Lymph Nodes on Frozen Sections

Author

Delverdier, Maxence, Abella, N., Schelcher, F., Pradeau, P., Espinasse, J., Cabanie, P., Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], General Veterinary, Antigens, CD, T-Lymphocyte Subsets, [SDV]Life Sciences [q-bio], Animals, Antibodies, Monoclonal, Frozen Sections, Cattle, Female, Lymph Nodes, General Medicine, Immunohistochemistry
Abstract

Many monoclonal antibodies reactive with bovine leukocyte differentiation antigens are now available. Immunohistochemical staining on frozen sections using these monoclonal antibodies permits study of the functional morphology of bovine lymph nodes. Our study confirms usually accepted notions (B and T dependent-zones) and supplies complementary data about the repartition of CD4 cells (particularly intrafollicular positive cells), gamma delta T cells, MHC II expression and dendritic leukocytes.

Published
1993
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16. Recherche de promoteurs de l’absorption intestinale des immunoglobulines du colostrum chez le veau et le poulain

Author

Jimenez-Lopez, Anne, Fauquant, Jacques, Lortal, Sylvie, Maubois, Jean-Louis, Beaucher, Eric, Robert, Benoit, Piot, Michel, Camier, Benedicte, Deherces, S., Schmitt, E., Servant, J.P., Betsch, JP, Spindler, N., Schelcher, F., Cassard, H., Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, IMV Technologies, Fromagerie Gillot, Clinique vétérinaire équine de Meuheudin, Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and ProdInra, Archive Ouverte

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.IDA]Life Sciences [q-bio]/Food engineering, [SDV.IDA] Life Sciences [q-bio]/Food engineering, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Recherche de promoteurs de l’absorption intestinale des immunoglobulines du colostrum chez le veau et le poulain . Journée Thématique Plateforme LAIT

Published
2010

17. Genetic resistance to scrapie infection in experimentally challenged goats

Author

Lacroux, C., Perrin-Chauvineau, C., Corbière, F., Aron, Naima, Aguilar-Calvo, Patricia, Torres, J. M., Costes, Pierrete, Brémaud, I., Lugan, Séverine, Schelcher, F., Barillet, F., Andréoletti, Olivier, Lacroux, C., Perrin-Chauvineau, C., Corbière, F., Aron, Naima, Aguilar-Calvo, Patricia, Torres, J. M., Costes, Pierrete, Brémaud, I., Lugan, Séverine, Schelcher, F., Barillet, F., and Andréoletti, Olivier

Abstract

In goats, several field studies have identified coding mutations of the gene encoding the prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a lower risk of developing classical scrapie. However, the data related to the levels of resistance to transmissible spongiform encephalopathies (TSEs) of these different PRNP gene mutations are still considered insufficient for developing large-scale genetic selection against scrapie in this species. In this study, we inoculated wild-type (WT) PRNP (I142R154R211Q222) goats and homozygous and/or heterozygous I/M142, R/H154, R/Q211, and Q/K222 goats with a goat natural scrapie isolate by either the oral or the intracerebral (i.c.) route. Our results indicate that the I/M142 PRNP polymorphism does not provide substantial resistance to scrapie infection following intracerebral or oral inoculation. They also demonstrate that H154, Q211, and K222 PRNP allele carriers are all resistant to scrapie infection following oral exposure. However, in comparison to WT animals, the H154 and Q211 allele carriers displayed only moderate increases in the incubation period following i.c. challenge. After i.c. challenge, heterozygous K222 and a small proportion of homozygous K222 goats also developed the disease, but with incubation periods that were 4 to 5 times longer than those in WT animals. These results support the contention that the K222 goat prion protein variant provides a strong but not absolutely protective effect against classical scrapie. © 2014, American Society for Microbiology.

Published
2014

18. Troubles respiratoires et croissance des bovins à l’engrais : importance des affections associées et de la période d’observation

Author

Corbière, Fabien, Philis, V, Besse, R, Lacroux, Caroline, Schelcher, F, ProdInra, Migration, Inconnu, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2009

20. Les lésions hépatiques chez les bovins : interprétation diagnostique

Author

Lacroux, Caroline, Schelcher, F, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Inconnu, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2008

22. Des animaux plus robustes : un enjeu majeur pour le développement durable des productions animales nécessitant l’essor du phénotypage fin et à haut débit

Author

PHOCAS, F., primary, BOBE, J., additional, BODIN, L., additional, CHARLEY, B., additional, DOURMAD, J.Y., additional, FRIGGENS, N.C., additional, Hocquette, J.F., additional, LE BAIL, P.Y., additional, LE BIHAN-DUVAL, E., additional, MORMÈDE, P., additional, QUÉRÉ, P., additional, and SCHELCHER, F., additional

Published
2014
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23. Facteurs génétiques et non génétiques de susceptibilité à la tremblante dans des élevages des Pyrénées atlantiques et utilisation de la génétique pour éradiquer la tremblante dans ces élevages

Author

Barillet, Francis, Andréoletti, Olivier, Duboucher, C., Fidèle, F., Minery, Stephanie, Arranz, J.M., Aguerre, X., SOULAS, Claude, Astruc, J.M., Schelcher, F., ProdInra, Migration, Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV] Life Sciences [q-bio], GENETIQUE ANIMALE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, RESISTANCE
Abstract

National audience

Published
2003

24. Identification of quantitative trait loci (QTL) modulating prion incubation period in sheep

Author

MORENO, C.R., COSSEDDU, G.M., Andreoletti, Olivier, Schibler, Laurent, Roig, Anne, Moazami Goudarzi, Katayoun, Eychenne, Francis, Lajous, Daniel, Schelcher, F., CRIBIU, E.P., Vaiman, Daniel, Elsen, J.M., ProdInra, Migration, Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], SHEEP, QTL, [SDV]Life Sciences [q-bio], PRION, DISEASE RESISTANCE, SCRAPIE
Published
2003

25. Sélection pour la résistance à la tremblante dans les populations ovines laitières françaises: Stratégie d'amélioration et principaux résultats depuis 1995

Author

Barillet, Francis, Aguerre, X., Arranz, J.M., MINERY, Stephanie, SOULAS, Claude, Belloc, J.P., Briois, Mickaël, Frégeat, G., Teinturier, P., Astruc, J.M., Palhière, Isabelle, Amigues, Yves, Andréoletti, Olivier, Schelcher, F., ProdInra, Migration, Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV] Life Sciences [q-bio], GENETIQUE ANIMALE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, RESISTANCE
Abstract

International audience

Published
2003

26. Scrapie epidemic in eight PrP-genotyped pedigree flocks of Manech red faced sheep and consequence of subsequent use of resistant ARR/AAA rams

Author

Barillet, Francis, Schelcher, F., Andréoletti, Olivier, Aguerre, X., Arranz, J.M., Duboucher, C., Corbière, Fabien, Fidèle, F., Soulas, Claude, ProdInra, Migration, Station d'Amélioration Génétique des Animaux (SAGA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], GENETIQUE ANIMALE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2003

27. Breeding for scrapie resistance using PrP henotyping in the french dairy sheep breeds

Author

Barillet, Francis, Andréoletti, Olivier, Palhière, Isabelle, Aguerre, X., Arranz, J.M., Minery, Stephanie, SOULAS, Claude, Belloc, J.P., Briois, Mickaël, Frégeat, G., Teinturier, P., Amigues, Yves, Astruc, J.M., Boscher, M.Y., Schelcher, F., Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], GENETIQUE ANIMALE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2002

28. Utilisation de la génétique pour éradiquer la tremblante dans les élevages de brebis laitières des Pyrénées-Atlantiques

Author

Minery, Stephanie, Arranz, J.M., Aguerre, X., Fidelle, F., Garrain, C., Vial-Novela, C., SOULAS, Claude, Palhière, Isabelle, Astruc, J.M., Andréoletti, Olivier, Schelcher, F., Barillet, Francis, ProdInra, Migration, Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV] Life Sciences [q-bio], GENETIQUE ANIMALE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2002

29. Herpèsviroses des ruminants. Le coryza gangrèneux chez les bovins

Author

Schelcher, F., Foucras, Gilles, Meyer, Gilles, Andréoletti, Olivier, ProdInra, Migration, Unité associée de Physiopathologie respiratoire des ruminants, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], CONTROLE DE MALADIES
Published
2001

30. Role de facteurs environnementaux et de l'hote dans la transmission horizontale et verticale de la tremblante ovine

Author

Gruner, L., Cabaret, Jacques, Barillet, Francis, Elsen, Jean Michel, Sarradin, Pierre, Lantier, Frédéric, Delattre, Pierre, Jacquiet, Philippe, Schelcher, F., Andréoletti, Olivier, Arranz, J.M., Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA), Station d'Amélioration Génétique des Animaux (SAGA), Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII), Laboratoire de recherches de la chaire de génétique, Unité associée de Physiopathologie respiratoire des ruminants, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2000

31. Accumulation précoce de la PRPSC dans les tissus lymphoïdes et nerveux du tube digestif d'agneaux atteints de tremblante naturelle

Author

Andréoletti, Olivier, Berthon, Patricia, Marc, Daniel, Sarradin, Pierre, Grosclaude, Jeanne, Schelcher, F., Elsen, Jean Michel, Lantier, Frédéric, Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Station d'Amélioration Génétique des Animaux (SAGA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2000

32. Bilan et analyse de trente mois de fonctionnement du réseau français d'épidémiosurveillance de la tremblante des petits ruminants

Author

Calavas, D., Philippe, S., Ducrot, Christian, Schelcher, F., Andréoletti, O., Belli, P., Fontaine, J.- J., Perrin, G., SAVEY, M., ProdInra, Migration, Agence Française de Sécurité Sanitaire des Aliments (AFSSA), Unité de Recherche d'Épidémiologie Animale (UR EpiA), Institut National de la Recherche Agronomique (INRA), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and École nationale vétérinaire d'Alfort (ENVA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], animal diseases
Abstract

International audience; The French Small Ruminant Scrapie Surveillance Scheme has been operating since scrapie became a notifiable disease in France on 14 June 1996. By 1 April 1999, suspicion of scrapie had been reported in 209 sheep flocks and 7 goat flocks, and histopathological diagnosis had been confirmed in 164 sheep flocks and 2 goat flocks. Scrapie was suspected in 37 counties and outbreaks occurred in 24 counties, one of them having 70% of the outbreaks. 66 outbreaks were identified in 1997 and 44 were identified in 1998. The cumulated incidence rate of sheep scrapie was significantly higher in 6 of the 23 counties in which scrapie was identified, compared with the national cumulated incidence rate (1.7/1000 flocks)

Published
1999

33. Dosage des D-lactates plasmatiques, intervalle de valeurs usuelles chez le veau

Author

Marcillaud, S., Schelcher, F., BRAUN, J.P., ProdInra, Migration, Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), Physiopathologie et Toxicologie Expérimentales (UPTE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1999

34. Beyond PrPres type 1/Type 2 dichotomy in Creutzfeldt-Jakob disease

Author

Uro-Coste, E., Cassard, H., Simon, S., Lugan, S., Bilheude, J.M., Perret-Liaudet, A., Ironside, J.E., Haik, S., Basset-Leobon, C., Lacroux, C., Peoch, K., Streichenberger, N., Langeveld, J.P.M., Head, M.W., Grassi, J., Hauw, J.J., Schelcher, F., Delisle, M.B., Andreoletti, O., Uro-Coste, E., Cassard, H., Simon, S., Lugan, S., Bilheude, J.M., Perret-Liaudet, A., Ironside, J.E., Haik, S., Basset-Leobon, C., Lacroux, C., Peoch, K., Streichenberger, N., Langeveld, J.P.M., Head, M.W., Grassi, J., Hauw, J.J., Schelcher, F., Delisle, M.B., and Andreoletti, O.

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently subclassified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K (PK) digested abnormal prion protein (PrPres) identified on Western blotting (type 1 or type 2). These biochemically distinct PrPres types have been considered to represent potential distinct prion strains. However, since cases of CJD show co-occurrence of type 1 and type 2 PrPres in the brain, the basis of this classification system and its relationship to agent strain are under discussion. Different brain areas from 41 sCJD and 12 iatrogenic CJD (iCJD) cases were investigated, using Western blotting for PrPres and two other biochemical assays reflecting the behaviour of the disease-associated form of the prion protein (PrPSc) under variable PK digestion conditions. In 30% of cases, both type 1 and type 2 PrPres were identified. Despite this, the other two biochemical assays found that PrPSc from an individual patient demonstrated uniform biochemical properties. Moreover, in sCJD, four distinct biochemical PrPSc subgroups were identified that correlated with the current sCJD clinico-pathological classification. In iCJD, four similar biochemical clusters were observed, but these did not correlate to any particular PRNP 129 polymorphism or western blot PrPres pattern. The identification of four different PrPSc biochemical subgroups in sCJD and iCJD, irrespective of the PRNP polymorphism at codon 129 and the PrPres isoform provides an alternative biochemical definition of PrPSc diversity and new insight in the perception of Human TSE agents variability

Published
2008

35. Rôle des nématodes parasites dans la transmission et le développement des ESST

Author

Gruner, L., Elsen, Jean Michel, Eychenne, Francis, CARITEZ, J.C., Lantier, Frédéric, Sarradin, Pierre, Schelcher, F., Station de Pathologie aviaire et parasitologie [Nouzilly] (PAP), Institut National de la Recherche Agronomique (INRA), Station d'Amélioration Génétique des Animaux (SAGA), Domaine expérimental de Langlade (LANGLADE), Génétique Expérimentale en Productions Animales (GEPA), Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII), Unité associée de Physiopathologie respiratoire des ruminants, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1998

36. Leçons de l'épidémie de tremblante dans le troupeau de Langlade

Author

Elsen, Jean Michel, Amigues, Yves, Schelcher, F., Ducrocq, Vincent, Andreoletti, Olivier, Eychenne, Francis, Vu Tien Khang Bourgoin, Jacqueline, Poivey, Jean Paul, Lantier, Frédéric, Laplanche, J.L., Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA), Station de Génétique Quantitative et Appliquée (SGQA), and Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII)

Subjects
GENETIQUE ANIMALE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1998

37. Differential diagnosis between abomasum torsion, mesenteric torsion and caecum dilatation/volvulus in calves

Author

Navetat, H., Schelcher, F., Rizet, Cl., Cabanie, P., and Espinasse, J.

Subjects
medicine.medical_specialty, biology, business.industry, Torsion (gastropod), Abdominal distension, medicine.disease, biology.organism_classification, digestive system, Abomasum, digestive system diseases, Volvulus, Surgery, Caecum, surgical procedures, operative, medicine.anatomical_structure, parasitic diseases, otorhinolaryngologic diseases, medicine, Differential diagnosis, medicine.symptom, Mesentery, business
Abstract

In calves aged 3-6 months, colics and abdominal distension are due to an abomasum torsion, a mesenteric torsion or to a caecum dilatation (with or without volvulus). A tabulated format of clinical signs may facilitate the differential diagnosis. Surgical and medical therapies are detailed., The Bovine Practitioner, No. 32.2 (1998 May)

Published
1998
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38. Histopathologie et tremblante : résultats et projets à l'ENVT

Author

Andréoletti, A., CABANIE, P., Berthon, Patricia, Elsen, Jean Michel, Schelcher, F., ProdInra, Migration, Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII), and Station d'Amélioration Génétique des Animaux (SAGA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1998

39. Looking for the mode of scrapie transmission and carrier status of resistant and susceptible sheep in a highly infected Romanov flock

Author

Elsen, J.M., BERTHON, Patricia, Sarradin, Pierre, VU TIEN KHANG, J., Andreoletti, Olivier, Schelcher, F., Amigues, Yves, Eychenne, Francis, POIVEY, J.P., Ducrocq, Vincent, Laplanche, J.L., Lantier, Frederic, Station de Génétique Quantitative et Appliquée (SGQA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], ANALYSE DE SURVIE
Published
1998

40. A scrapie epidemic in a closed flock of Romanov

Author

Elsen, Jean Michel, Vu Tien Khang Bourgoin, Jacqueline, Schelcher, F., Amigues, Yves, Eychenne, Francis, Poivey, Jean Paul, Lantier, Frédéric, Laplanche, J.L., ProdInra, Migration, Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Cytogénétique des Populations Animales (CPA), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1998

41. Les leçons d'une épidémie de tremblante du mouton

Author

Elsen, Jean Michel, Barillet, Francis, Vu Tien Khang Bourgoin, Jacqueline, Schelcher, F., Amigues, Yves, Laplanche, J.L., Poivey, Jean Paul, Eychenne, Francis, Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Unité de recherches de Physiologie animale (JOUY PHYSIO A), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

"Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "; National audience

Published
1997

42. Génétique de la sensibilité à la tremblante ovine: recherches en cours et perspectives

Author

Elsen, Jean Michel, Barillet, Francis, Vu Tien Khang Bourgoin, Jacqueline, Schelcher, F., Amigues, Yves, Laplanche, J.L., Poivey, Jean Paul, Eychenne, Francis, Station d'Amélioration Génétique des Animaux (SAGA), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

National audience; In several species (man, mouse, sheep), the susceptibility to transmissible subacute spongiform encephalopathies is highly regulated by the host genotype, A major part of the observed genetic variability depends on one gene, This gene is likely the Prn-p gene, which codes for the host prion protein PrP, According to an hypothesis supported by several authors, this protein could be the causal agent of these diseases or it could be associated with the causal agent, Molecular analysis of the structure of the Prn-p gene in sheep demonstrates segregating alleles that differ from each other by a single mutation, It could be interesting, therefore, to examine the possibility of controlling scrapie in sheep by selective breeding on the basis of laboratory analyses of the Prn-p gene polymorphism. Before selecting against this susceptibility however, different questions need to be answered: Could resistant animals act as a source of infection? Could animals resistant to one scrapie strain be susceptible to another? How expensive would such a selection scheme be? How should the selection be organised in practice?; Dans plusieurs espèces (homme, souris, mouton), la sensibilité aux encéphalopathies spongiformes subaiguës transmissibles (ESST) est largement contrôlée par le génotype de l’hôte. Une part majeure de la variabilité génétique observée vient d’un gène, dont plusieurs arguments permettent de penser qu’il s’agit du gène Prn-pcodant pour la protéine prion PrP, qui pourrait, selon certains auteurs, être l’agent causal de ces pathologies ou être associé à ce dernier. L’analyse moléculaire de la structure du gène Prn-p chez le mouton montre la ségrégation d’allèles différant les uns des autres par une mutation ponctuelle. Une sélection pour la résistance à la tremblante, basée sur des analyses en laboratoire du gène Prn-p, est donc envisageable dans cette espèce. La mise en place d’une telle sélection pose cependant plusieurs problèmes théoriques et pratiques : les animaux résistants pourraient-ils constituer un réservoir d’infection ? Les animaux résistants à une souche de tremblante pourraient-ils se révéler sensibles à une autre ? Le coût de cette sélection est-il acceptable ? Comment l’organiser au mieux ?

Published
1997

43. Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep

Author

Lantier, Frederic [0000-0001-5896-330X], Andréoletti, Olivier, Morel, N., Lacroux, C., Rouillon, V., Barc, C., Tabouret, G., Sarradin, P., Berthon, P., Bernardet, P., Mathey, J., Lugan, Séverine, Costes, Pierrete, Corbière, F., Espinosa Martín, Juan Carlos, Torres, J. M., Grassi, J., Schelcher, F., Lantier, Frederic, Lantier, Frederic [0000-0001-5896-330X], Andréoletti, Olivier, Morel, N., Lacroux, C., Rouillon, V., Barc, C., Tabouret, G., Sarradin, P., Berthon, P., Bernardet, P., Mathey, J., Lugan, Séverine, Costes, Pierrete, Corbière, F., Espinosa Martín, Juan Carlos, Torres, J. M., Grassi, J., Schelcher, F., and Lantier, Frederic

Abstract

Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrPSc in the spleen. © 2006 SGM.

Published
2006

44. Preliminary analyses of a scrapie epidemic in a closed flock of Romanov

Author

Elsen, Jean Michel, Schelcher, F., Amigues, Yves, Laplanche, J.L., Clouscard, C., Poivey, Jean Paul, Vu Tien Khang Bourgoin, Jacqueline, Eychenne, Francis, Sarradin, Pierre, Lantier, Frédéric, Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Unité associée de Physiopathologie respiratoire des ruminants, Laboratoire d'Analyse Génétique pour les Espèces Animales (LABOGENA), Génétique Moléculaire et Cellulaire (UGMC), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), and Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1996

45. An immunohistochemical study of bovine palatine and pharyngeal tonsils

Author

Manesse, M., Delverdier, Maxence, Abella-Bourges, N., Amardeilh, M.F., Sautet, J., Cabanie, P., Schelcher, F., Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
1996

46. Scrapie outbreak in sheep after oral exposure to infective gastrointestinal nematode larvae

Author

Laplanche, J.L., Elsen, Jean Michel, Eychenne, Francis, Schelcher, F., Richard, S., Amigues, Yves, Launay, J.M., Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], MALADIE TRANSMISSIBLE, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1996

47. La tremblante des ovins

Author

Schelcher, F., Andréoletti, Olivier, CABANIE, P., ProdInra, Migration, Unité associée de Physiopathologie respiratoire des ruminants, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
1996

48. Evaluation d'un test ELISA de capture antigénique et conséquences pratiques pour le diagnostic de l'infection par le BVDV

Author

Foucras, Gilles, CARNERO, R., Perlier, C., Schelcher, F., ProdInra, Migration, Unité associée de Physiopathologie respiratoire des ruminants, and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
Published
1996

50. Les gastro-entérites paralysantes : Une revue

Author

Navetat, H., Contrepois, M., Schelcher, F., Valarcher, J.R., Rizet, C., ESPINASSE, J., ProdInra, Migration, Unité de Microbiologie (MIC), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], épidémio-clinique, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1996

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